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Bileaflet mitral valve prolapse

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https://www.readbyqxmd.com/read/29884292/role-of-genetic-heart-disease-in-sentinel-sudden-cardiac-arrest-survivors-across-the-age-spectrum
#1
John R Giudicessi, Michael J Ackerman
BACKGROUND: Sudden cardiac arrest (SCA) may be the sentinel expression of a sudden cardiac death-predisposing genetic heart disease (GHD). Although shown to underlie many unexplained SCAs in the young, the contribution of GHDs to sentinel SCA has never been quantified across the age spectrum. Thus, we sought to determine the contribution of GHDs in single-center referral cohort of non-ischemic SCA survivors. METHODS AND RESULTS: Retrospective analysis of 3037 patients was used to identify all individuals who experienced a sentinel event of SCA...
May 30, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29876289/recurrent-premature-ventricular-contraction-induced-ventricular-fibrillation-and-resuscitated-sudden-death-in-a-26-year-old-pregnant-woman-with-bileaflet-mitral-valve-prolapse
#2
Tisa Saha, Robert Norris, Jeffrey Luebbert
No abstract text is available yet for this article.
February 2018: HeartRhythm Case Reports
https://www.readbyqxmd.com/read/29750930/a-simplified-technique-for-complex-mitral-valve-regurgitation-via-minimally-invasive-approach
#3
Giuseppe Speziale, Marco Moscarelli, Nicola Di Bari, Raffaele Bonifazi, Massimo Salardino, Teresa De Donatis, Giusepe Nasso
BACKGROUND: Complex mitral valve disease can require surgical repair techniques that are challenging in a minimally invasive context and may expose patients to prolonged cardiopulmonary bypass and cross clamp times. Here, we review our simplified stepwise operative approach for the treatment of complex bileaflet mitral disease, on early outcomes and mid-term follow-up. METHODS: One hundred and forty consecutive patients with bileaflet disease underwent video-assisted right minimally invasive mitral valve repair at our surgical center between 2008 and 2016...
May 8, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29709354/simple-versus-complex-degenerative-mitral-valve-disease
#4
Hoda Javadikasgari, Tomislav Mihaljevic, Rakesh M Suri, Lars G Svensson, Jose L Navia, Robert Z Wang, Bassman Tappuni, Ashley M Lowry, Kenneth R McCurry, Eugene H Blackstone, Milind Y Desai, Stephanie L Mick, A Marc Gillinov
OBJECTIVES: At a center where surgeons favor mitral valve (MV) repair for all subsets of leaflet prolapse, we compared results of patients undergoing repair for simple versus complex degenerative MV disease. METHODS: From January 1985 to January 2016, 6153 patients underwent primary isolated MV repair for degenerative disease, 3101 patients underwent primary isolated MV repair for simple disease (posterior prolapse), and 3052 patients underwent primary isolated MV repair for complex disease (anterior or bileaflet prolapse), based on preoperative echocardiographic images...
April 4, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29673010/the-nightmare-ecg-of-a-spontaneously-aborted-sudden-cardiac-death
#5
Giovanni Coluccia, Raffaele Punzi, Silvia Polini, Concetto La Rosa, Mariano Rillo
We present the case of a spontaneously aborted sudden cardiac death related to an high-rate ventricular tachycardia in an healthy man with bileaflet mitral valve prolapse. An effective treatment of the patient, with complete suppression of ventricular ectopic activity, was achieved only combining medical therapy, ICD and catheter ablation, thus overcoming the limitations of each approach.
April 19, 2018: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/29514183/an-early-european-experience-with-transapical-off-pump-mitral-valve-repair-with-neochord-implantation
#6
Andrea Colli, Erica Manzan, Audrius Aidietis, Kestutis Rucinskas, Eleonora Bizzotto, Laura Besola, Nicola Pradegan, Demetrio Pittarello, Vilius Janusauskas, Diana Zakarkaite, Agne Drasutiene, Arturas Lipnevicius, Bernhard C Danner, Horst Sievert, Laura Vaskelyte, Nalan Schnelle, Stefano Salizzoni, Massimo Marro, Mauro Rinaldi, Katarzyna Kurnicka, Kristof Wrobel, Mariano Ceffarelli, Carlo Savini, Davide Pacini, Gino Gerosa
OBJECTIVES: Transapical off-pump NeoChord repair is a novel minimally invasive surgical procedure to treat degenerative mitral valve regurgitation. The aim was to evaluate 1-year clinical results of the NeoChord procedure in a consecutive cohort of patients. METHODS: Between February 2013 and July 2016, 213 patients were enrolled in the NeoChord Independent International Registry. All patients presented severe mitral regurgitation due to flail/prolapse of 1 or both leaflets, and they all completed postoperative echocardiographic assessment up to 1 year...
March 5, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29486707/genomic-analysis-in-patients-with-myxomatous-mitral-valve-prolapse-current-state-of-knowledge
#7
S Gasser, H Reichenspurner, E Girdauskas
BACKGROUND: Myxomatous mitral valve prolapse is a common cardiac abnormality. Morbus Barlow is characterized by excess myxomatous leaflet tissue, bileaflet prolapse or billowing, chordae elongation and annular dilatation with or without calcification. Extensive myxoid degeneration with destruction of the normal three-layered leaflet tissue architecture is observed histologically in such patients. Autosomal dominant inheritance with an age and sex-dependent expression has long been recognised...
February 27, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29312750/mitral-valve-prolapse-an-underestimated-cause-of-sudden-cardiac-death-a-current-review-of-the-literature
#8
REVIEW
Michael Spartalis, Eleni Tzatzaki, Eleftherios Spartalis, Antonios Athanasiou, Demetrios Moris, Christos Damaskos, Nikolaos Garmpis, Vassilis Voudris
Mitral valve prolapse (MVP) is a common valve abnormality in general population. Despite the general belief of a benign disorder, several articles since the 1980s report sudden cardiac death (SCD) in MVP patients, with a substantial percentage of asymptomatic young individuals. The problem is to detect those patients at increased risk and implement methods that are suitable to prevent cardiac arrest. This review investigates the correlation between MVP and SCD, the understanding of the pathophysiology, the strategies for detecting those at risk and treatment options...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29186494/mitral-valve-repair-in-barlow-s-disease-with-bileaflet-prolapse-the-effect-of-annular-stabilization-on-functional-mitral-valve-leaflet-prolapse
#9
Anton Tomšic, Yasmine L Hiemstra, Daniella D Bissessar, Thomas J van Brakel, Michel I M Versteegh, Nina Ajmone Marsan, Robert J M Klautz, Meindert Palmen
OBJECTIVES: Barlow's disease is the most severe form of degenerative mitral valve disease, commonly characterized by bileaflet prolapse. Abnormal mitral annular dynamics is typically present and results in functional prolapse of the mitral leaflets that may be addressed with annular stabilization alone. METHODS: Between January 2001 and December 2015, 128 patients with Barlow's disease and bileaflet prolapse underwent valve repair. This included anterior mitral valve leaflet (AMVL) repair in 70 patients, whereas 58 patients were identified as having functional prolapse and underwent no specific AMVL repair...
April 1, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29059484/imaging-characteristics-of-papillary-muscle-site-of-origin-of-ventricular-arrhythmias-in-patients-with-mitral-valve-prolapse
#10
Brian L Fulton, Jackson J Liang, Andres Enriquez, Fermin C Garcia, Gregory E Supple, Michael P Riley, Robert D Schaller, Sanjay Dixit, David J Callans, Francis E Marchlinski, Yuchi Han
BACKGROUND: Mitral valve prolapse has been associated with increased risk of ventricular arrhythmias. We aimed to examine whether certain cardiac imaging characteristics are associated with papillary muscle origin of ventricular arrhythmias in these patients. METHODS AND RESULTS: We screened electronic medical records of all patients documented to have mitral valve prolapse on either transthoracic echocardiogram (TTE) or cardiac magnetic resonance imaging (CMR) in our center, who also underwent an electrophysiologic study (EPS) between 2007 and 2016...
January 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28750632/impact-of-bileaflet-mitral-valve-prolapse-on-quantification-of-mitral-regurgitation-with-cardiac-magnetic-resonance-a-single-center-study
#11
Gabriella Vincenti, Pier Giorgio Masci, Tobias Rutz, Jonathan De Blois, Milan Prša, Xavier Jeanrenaud, Juerg Schwitter, Pierre Monney
BACKGROUND: To quantify mitral regurgitation (MR) with CMR, the regurgitant volume can be calculated as the difference between the left ventricular (LV) stroke volume (SV) measured with the Simpson's method and the reference SV, i.e. the right ventricular SV (RVSV) in patients without tricuspid regurgitation. However, for patients with prominent mitral valve prolapse (MVP), the Simpson's method may underestimate the LV end-systolic volume (LVESV) as it only considers the volume located between the apex and the mitral annulus, and neglects the ventricular volume that is displaced into the left atrium but contained within the prolapsed mitral leaflets at end systole...
July 27, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28477226/-malignant-bileaflet-mitral-valve-prolapse-syndrome-in-otherwise-idiopathic-ventricular-fibrillation
#12
Dirk Vollmann, Claudius Hansen, Lars Lüthje, Ole A Breithardt
A 32-year-old, otherwise healthy woman was admitted after successful out-of-hospital resuscitation due to ventricular fibrillation. Established cardiac, pulmonary, metabolic, and toxicological causes were excluded. However, persisting (biphasic) negative T waves in the inferior ECG leads and premature ventricular contractions (PVC) were noted. PVC morphology indicated a focus alternating between the posterior papillary muscle/the left posterior fascicle and the left ventricular outflow tract region/anterior papillary muscle...
June 2017: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/28415082/p210long-term-outcome-of-primary-mitral-valve-prolapse-results-from-a-population-of-250-patients-referred-to-a-tertiary-cardiovascular-center
#13
V Mecarocci, F Mori
Background: Outcome of Mitral Valve Prolapse (MVP) was controversial for long time. Many studies reported great differences in the incidence of cardiovascular events due, above all, to heterogeneous and small studied populations. Most of theme were also published to late '80 of the last century till early '00. Purpose: To make a contemporary survey on the incidence of cardiovascular events in a selected population of patients affected by primary MVP referred to a tertiary cardiovascular center for the medical and surgical care of valvular heart disease...
December 1, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28401865/the-effect-of-mitral-valve-surgery-on-ventricular-arrhythmia-in-patients-with-bileaflet-mitral-valve-prolapse
#14
Niyada Naksuk, Faisal F Syed, Chayakrit Krittanawong, Mark J Anderson, Elisa Ebrille, Christopher V DeSimone, Vaibhav R Vaidya, Shiva P Ponamgi, Rakesh M Suri, Michael J Ackerman, Vuyisile T Nkomo, Samuel J Asirvatham, Peter A Noseworthy
BACKGROUND: Bileaflet mitral valve prolapse (biMVP) is associated with frequent ventricular ectopy (VE) and malignant ventricular arrhythmia. We examined the effect of mitral valve (MV) surgery on VE burden in biMVP patients. METHODS: We included 32 consecutive patients undergoing MV surgery for mitral regurgitation secondary to biMVP between 1993 and 2012 at Mayo Clinic who had available pre- and post-operative Holter monitoring data. Characteristics of patients with a significant reduction in postoperative VE (group A, defined as >10% reduction in VE burden compared to baseline) were compared with the rest of study patients (group B)...
November 2016: Indian Pacing and Electrophysiology Journal
https://www.readbyqxmd.com/read/28290171/effects-of-surgical-techniques-on-long-term-results-in-patients-with-degenerative-mitral-valve-bileaflet-prolapse
#15
Giuseppe Petrone, Renato Bellitti, Clemente Pascarella, Gianantonio Nappi, Giuseppe Signoriello, Pasquale Santé
BACKGROUND AND AIM OF THE STUDY: The study aim was to evaluate the long-term results in patients with degenerative mitral valve bileaflet prolapse (DMVBLP) undergoing mitral valve repair (MVr) or mitral valve replacement (MVR), and to compare the consequences of survival related to each technique. METHODS: Between 2001 and 2012, a total of 421 patients underwent isolated primary surgery for DMVBLP. MVr was performed in 146 patients (34.7%), and MVR in 275 (65.3%)...
November 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28155223/evaluation-of-prolonged-qt-interval-structural-heart-disease-mimicking-long-qt-syndrome
#16
Adaya Weissler-Snir, Michael H Gollob, Vijay Chauhan, Melanie Care, Danna A Spears
BACKGROUND: In about 20-25% of patients with congenital long QT syndrome (LQTS) a causative pathogenic mutation is not found. The aim of this study was to explore the prevalence of alternative cardiac diagnoses among patients exhibiting prolongation of QT interval with negative genetic testing for LQTS genes. METHODS: We conducted a retrospective analysis of 239 consecutive patients who were evaluated in the inherited arrhythmia clinic at the Toronto General Hospital between July 2013 and December 2015 for possible LQTS...
April 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28104197/simplified-mitral-valve-repair-in-pediatric-patients-with-connective-tissue-disorders
#17
Luca A Vricella, William A Ravekes, Eloisa Arbustini, Robert D B Jaquiss, Constantine Mavroudis, Harry C Dietz, Marshall L Jacobs, Narutoshi Hibino, Duke E Cameron
BACKGROUND: In pediatric patients with connective tissue disorders (CTDs), early cardiac presentation often involves severe mitral regurgitation (MR) associated with severe bileaflet prolapse and, less frequently, aortic root enlargement. We adopted a simplified repair to address MR and prevent systolic anterior motion (SAM) in this unique group of patients. MATERIALS AND METHODS: Retrospective review of clinical and echocardiographic data of all pediatric patients (age < 18 years) with CTD and MR undergoing simplified repair at 3 institutions (2000-2014)...
February 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27720370/how-does-mitral-valve-repair-fail-in-patients-with-prolapse-insights-from-longitudinal-echocardiographic-follow-up
#18
Vincent Chan, Elsayed Elmistekawy, Marc Ruel, Mark Hynes, Thierry G Mesana
BACKGROUND: Repair of mitral regurgitation (MR) caused by prolapse has been well validated. Although favorable early and late results after repair have been reported, few data are available that mechanistically describe how a mitral repair fails beyond the mere need for mitral valve reoperation. We therefore sought to determine the modes of valve repair failure in patients who underwent surgical correction of MR caused by prolapse. METHODS: Between 2001 and 2015, 855 patients underwent repair of MR caused by prolapse...
November 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27103091/sites-of-successful-ventricular-fibrillation-ablation-in-bileaflet-mitral-valve-prolapse-syndrome
#19
Faisal F Syed, Michael J Ackerman, Christopher J McLeod, Suraj Kapa, Siva K Mulpuru, Chenni S Sriram, Bryan C Cannon, Samuel J Asirvatham, Peter A Noseworthy
BACKGROUND: Although the vast majority of mitral valve prolapse (MVP) is benign, a small subset of patients, predominantly women, with bileaflet prolapse, complex ventricular ectopy (VE), and abnormal T waves comprise the recently described bileaflet MVP syndrome. We compared findings on electrophysiological study in bileaflet MVP syndrome patients with and without cardiac arrest to identify factors that may predispose to malignant ventricular arrhythmia. METHODS AND RESULTS: Fourteen consecutive bileaflet MVP syndrome patients (n=13 women; median [limits], age at index ablation, 33...
May 2016: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/26846946/effect-of-recurrent-mitral-regurgitation-following-degenerative-mitral-valve-repair-long-term-analysis-of-competing-outcomes
#20
Rakesh M Suri, Marie-Annick Clavel, Hartzell V Schaff, Hector I Michelena, Marianne Huebner, Rick A Nishimura, Maurice Enriquez-Sarano
BACKGROUND: The risk for and consequences of recurrent mitral regurgitation (MR) following degenerative mitral valve repair are poorly understood. OBJECTIVES: This study sought to examine recurrent MR risk along with reoperation and survival rates. METHODS: We evaluated patients undergoing primary mitral repair for isolated degenerative MR over 1 decade. Median follow-up was 11.5 years (interquartile range: 9.2 to 13.6 years) and was 99% complete...
February 9, 2016: Journal of the American College of Cardiology
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