keyword
MENU ▼
Read by QxMD icon Read
search

drosophila peripheral nervous system

keyword
https://www.readbyqxmd.com/read/28503020/circadian-rhythm-in-mrna-expression-of-the-glutathione-synthesis-gene-gclc-is-controlled-by-peripheral-glial-clocks-in-drosophila-melanogaster
#1
Eileen S Chow, Dani M Long, Jadwiga M Giebultowicz
Circadian coordination of metabolism, physiology, and behaviour is found in all living kingdoms. Clock genes are transcriptional regulators, and their rhythmic activities generate daily rhythms in clock-controlled genes which result in cellular and organismal rhythms. Insects provide numerous examples of rhythms in behaviour and reproduction, but less is known about control of metabolic processes by circadian clocks in insects. Recent data suggest that several pathways involved in protecting cells from oxidative stress may be modulated by the circadian system, including genes involved in glutathione (GSH) biosynthesis...
December 2016: Physiological Entomology
https://www.readbyqxmd.com/read/28388016/remodeling-of-peripheral-nerve-ensheathment-during-the-larval-to-adult-transition-in-drosophila
#2
Aswati Subramanian, Matthew Siefert, Soumya Banerjee, Kumar Vishal, Kayla A Bergmann, Clay C M Curts, Meredith Dorr, Camillo Molina, Joyce Fernandes
Over the course of a four-day period of metamorphosis, the Drosophila larval nervous system is remodeled to prepare for adult-specific behaviors. One example is the reorganization of peripheral nerves in the abdomen, where five pairs of abdominal nerves (A4-A8) fuse to form the terminal nerve trunk. This reorganization is associated with selective remodeling of four layers that ensheath each peripheral nerve. The neural lamella (NL), is the first to dismantle; its breakdown is initiated by 6 hours after puparium formation, and is completely removed by the end of the first day...
April 7, 2017: Developmental Neurobiology
https://www.readbyqxmd.com/read/28174239/ataxin-2-binding-protein-1-is-a-context-specific-positive-regulator-of-notch-signaling-during-neurogenesis-in-drosophila-melanogaster
#3
Jay Prakash Shukla, Girish Deshpande, L S Shashidhara
The role of the Notch pathway during the lateral inhibition that underlies binary cell fate choice is extensively studied, but the context specificity that generates diverse outcomes is less well understood. In the peripheral nervous system of Drosophila melanogaster, differential Notch signaling between cells of the proneural cluster orchestrates sensory organ specification. Here we report functional analysis of Drosophila Ataxin 2-binding protein 1 (A2BP1) during this process. Its human ortholog is linked to type 2 spinocerebellar ataxia and other complex neuronal disorders...
March 1, 2017: Development
https://www.readbyqxmd.com/read/28107480/drosophila-vps13-is-required-for-protein-homeostasis-in-the-brain
#4
Jan J Vonk, Wondwossen M Yeshaw, Francesco Pinto, Anita I E Faber, Liza L Lahaye, Bart Kanon, Marianne van der Zwaag, Antonio Velayos-Baeza, Raimundo Freire, Sven C van IJzendoorn, Nicola A Grzeschik, Ody C M Sibon
Chorea-Acanthocytosis is a rare, neurodegenerative disorder characterized by progressive loss of locomotor and cognitive function. It is caused by loss of function mutations in the Vacuolar Protein Sorting 13A (VPS13A) gene, which is conserved from yeast to human. The consequences of VPS13A dysfunction in the nervous system are still largely unspecified. In order to study the consequences of VPS13A protein dysfunction in the ageing central nervous system we characterized a Drosophila melanogaster Vps13 mutant line...
2017: PloS One
https://www.readbyqxmd.com/read/28028818/a-mechanism-for-sickness-sleep-lessons-from-invertebrates
#5
Kristen C Davis, David M Raizen
During health, animal sleep is regulated by an internal clock and by the duration of prior wakefulness. During sickness, sleep is regulated by cytokines released from either peripheral cells or from cells within the nervous system. These cytokines regulate central nervous system neurons to induce sleep. Recent research in the invertebrates Caenorhabditis elegans and Drosophila melanogaster has led to new insights into the mechanism of sleep during sickness. Sickness is triggered by exposure to environments such as infection, heat, or ultraviolet light irradiation, all of which cause cellular stress...
December 28, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27888110/tubby-domain-superfamily-protein-is-required-for-the-formation-of-the-7s-snare-complex-in-drosophila
#6
Eun Jang Yoon, Yong Taek Jeong, Ji Eun Lee, Seok Jun Moon, Chul Hoon Kim
Tubby domain superfamily protein (TUSP) is a distant member of the Tubby-like protein (TULP) family. Although other TULPs play important roles in sensation, metabolism, and development, the molecular functions of TUSP are completely unknown. Here, we explore the function of TUSP in the Drosophila nervous system where it is expressed in all neurons. Tusp mutant flies exhibit a temperature-sensitive paralysis. This paralysis can be rescued by tissue-specific expression of Tusp in the giant fibers and peripherally synapsing interneurons of the giant fiber system, a well-characterized neuronal circuit that mediates rapid escape behavior in flies...
January 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27637927/differential-ligand-regulation-of-plexb-signaling-in-motor-neuron-axon-guidance-in-drosophila
#7
Seyun Roh, Da-Som Yang, Sangyun Jeong
Plexins (Plexs) are a large family of phylogenetically conserved guidance receptors that bind specifically to semaphorins (Semas), another large family of guidance molecules. In the Drosophila embryonic central nervous system (CNS), the secreted semaphorins Sema-2a and Sema-2b both act as ligands for PlexB, but mediate mutually independent and opposite functions (repulsive and attractive guidance, respectively). PlexB is also known to regulate motor axon guidance in the embryonic peripheral nervous system (PNS)...
December 2016: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/27598401/an-intronic-polymorphism-in-couch-potato-is-not-distributed-clinally-in-european-drosophila-melanogaster-populations-nor-does-it-affect-diapause-inducibility
#8
Valeria Zonato, Giorgio Fedele, Charalambos P Kyriacou
couch potato (cpo) encodes an RNA binding protein that has been reported to be expressed in the peripheral and central nervous system of embryos, larvae and adults, including the major endocrine organ, the ring gland. A polymorphism in the D. melanogaster cpo gene coding region displays a latitudinal cline in frequency in North American populations, but as cpo lies within the inversion In(3R)Payne, which is at high frequencies and itself shows a strong cline on this continent, interpretation of the cpo cline is not straightforward...
2016: PloS One
https://www.readbyqxmd.com/read/27588305/presynaptic-gaba-receptors-mediate-temporal-contrast-enhancement-in-drosophila-olfactory-sensory-neurons-and-modulate-odor-driven-behavioral-kinetics
#9
Davide Raccuglia, Li Yan McCurdy, Mahmut Demir, Srinivas Gorur-Shandilya, Michael Kunst, Thierry Emonet, Michael N Nitabach
Contrast enhancement mediated by lateral inhibition within the nervous system enhances the detection of salient features of visual and auditory stimuli, such as spatial and temporal edges. However, it remains unclear how mechanisms for temporal contrast enhancement in the olfactory system can enhance the detection of odor plume edges during navigation. To address this question, we delivered to Drosophila melanogaster flies pulses of high odor intensity that induce sustained peripheral responses in olfactory sensory neurons (OSNs)...
July 2016: ENeuro
https://www.readbyqxmd.com/read/27555807/caffeine-taste-signaling-in-drosophila-larvae
#10
Anthi A Apostolopoulou, Saskia Köhn, Bernhard Stehle, Michael Lutz, Alexander Wüst, Lorena Mazija, Anna Rist, C Giovanni Galizia, Alja Lüdke, Andreas S Thum
The Drosophila larva has a simple peripheral nervous system with a comparably small number of sensory neurons located externally at the head or internally along the pharynx to assess its chemical environment. It is assumed that larval taste coding occurs mainly via external organs (the dorsal, terminal, and ventral organ). However, the contribution of the internal pharyngeal sensory organs has not been explored. Here we find that larvae require a single pharyngeal gustatory receptor neuron pair called D1, which is located in the dorsal pharyngeal sensilla, in order to avoid caffeine and to associate an odor with caffeine punishment...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/27507933/analysis-of-amyloid-precursor-protein-function-in-drosophila-melanogaster
#11
REVIEW
Marlène Cassar, Doris Kretzschmar
The Amyloid precursor protein (APP) has mainly been investigated in connection with its role in Alzheimer's Disease (AD) due to its cleavage resulting in the production of the Aβ peptides that accumulate in the plaques characteristic for this disease. However, APP is an evolutionary conserved protein that is not only found in humans but also in many other species, including Drosophila, suggesting an important physiological function. Besides Aβ, several other fragments are produced by the cleavage of APP; large secreted fragments derived from the N-terminus and a small intracellular C-terminal fragment...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27162329/prevalent-presence-of-periodic-actin-spectrin-based-membrane-skeleton-in-a-broad-range-of-neuronal-cell-types-and-animal-species
#12
Jiang He, Ruobo Zhou, Zhuhao Wu, Monica A Carrasco, Peri T Kurshan, Jonathan E Farley, David J Simon, Guiping Wang, Boran Han, Junjie Hao, Evan Heller, Marc R Freeman, Kang Shen, Tom Maniatis, Marc Tessier-Lavigne, Xiaowei Zhuang
Actin, spectrin, and associated molecules form a periodic, submembrane cytoskeleton in the axons of neurons. For a better understanding of this membrane-associated periodic skeleton (MPS), it is important to address how prevalent this structure is in different neuronal types, different subcellular compartments, and across different animal species. Here, we investigated the organization of spectrin in a variety of neuronal- and glial-cell types. We observed the presence of MPS in all of the tested neuronal types cultured from mouse central and peripheral nervous systems, including excitatory and inhibitory neurons from several brain regions, as well as sensory and motor neurons...
May 24, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/26996133/models-of-axon-regeneration-in-drosophila
#13
REVIEW
E J Brace, Aaron DiAntonio
Maintaining neuronal connectivity in the face of injury and disease is a major challenge for the nervous system. The great length of axons makes them particularly vulnerable to insult with dire consequences for neuronal function. In the peripheral nervous system there is a program of axonal regeneration that can reestablish connectivity. In the mammalian central nervous system, however, injured axons have little or no capacity to regenerate. The molecular mechanisms that promote axon regeneration have begun to be identified and many of the implicated pathways are evolutionarily conserved...
January 2017: Experimental Neurology
https://www.readbyqxmd.com/read/26898323/distal-less-homeobox-genes-of-insects-and-spiders-genomic-organization-function-regulation-and-evolution
#14
COMPARATIVE STUDY
Bin Chen, William H Piel, Antónia Monteiro
The Distal-less (Dll) genes are homeodomain transcription factors that are present in most Metazoa and in representatives of all investigated arthropod groups. In Drosophila, the best studied insect, Dll plays an essential role in forming the proximodistal axis of the legs, antennae and analia, and in specifying antennal identity. The initiation of Dll expression in clusters of cells in mid-lateral regions of the Drosophila embryo represents the earliest genetic marker of limbs. Dll genes are involved in the development of the peripheral nervous system and sensitive organs, and they also function as master regulators of black pigmentation in some insect lineages...
June 2016: Insect Science
https://www.readbyqxmd.com/read/26818504/accumulation-of-laminin-monomers-in-drosophila-glia-leads-to-glial-endoplasmic-reticulum-stress-and-disrupted-larval-locomotion
#15
Lindsay M Petley-Ragan, Evan L Ardiel, Catharine H Rankin, Vanessa J Auld
UNLABELLED: The nervous system is surrounded by an extracellular matrix composed of large glycoproteins, including perlecan, collagens, and laminins. Glial cells in many organisms secrete laminin, a large heterotrimeric protein consisting of an α, β, and γ subunit. Prior studies have found that loss of laminin subunits from vertebrate Schwann cells causes loss of myelination and neuropathies, results attributed to loss of laminin-receptor signaling. We demonstrate that loss of the laminin γ subunit (LanB2) in the peripheral glia of Drosophila melanogaster results in the disruption of glial morphology due to disruption of laminin secretion...
January 27, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/26721856/a-novel-gene-controlling-the-timing-of-courtship-initiation-in-drosophila-melanogaster
#16
Peter Luu, Sadaf A Zaki, David H Tran, Rachael L French
Over the past 35 years, developmental geneticists have made impressive progress toward an understanding of how genes specify morphology and function, particularly as they relate to the specification of each physical component of an organism. In the last 20 years, male courtship behavior in Drosophila melanogaster has emerged as a robust model system for the study of genetic specification of behavior. Courtship behavior is both complex and innate, and a single gene, fruitless (fru), is both necessary and sufficient for all aspects of the courtship ritual...
March 2016: Genetics
https://www.readbyqxmd.com/read/26650404/assaying-blood-cell-populations-of-the-drosophila-melanogaster-larva
#17
Sophia Petraki, Brandy Alexander, Katja Brückner
In vertebrates, hematopoiesis is regulated by inductive microenvironments (niches). Likewise, in the invertebrate model organism Drosophila melanogaster, inductive microenvironments known as larval Hematopoietic Pockets (HPs) have been identified as anatomical sites for the development and regulation of blood cells (hemocytes), in particular of the self-renewing macrophage lineage. HPs are segmentally repeated pockets between the epidermis and muscle layers of the larva, which also comprise sensory neurons of the peripheral nervous system...
November 11, 2015: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/26472170/expression-of-the-drosophila-homeobox-gene-distal-less-supports-an-ancestral-role-in-neural-development
#18
Jessica S Plavicki, Jayne M Squirrell, Kevin W Eliceiri, Grace Boekhoff-Falk
BACKGROUND: Distal-less (Dll) encodes a homeodomain transcription factor expressed in developing appendages of organisms throughout metazoan phylogeny. Based on earlier observations in the limbless nematode Caenorhabditis elegans and the primitive chordate amphioxus, it was proposed that Dll had an ancestral function in nervous system development. Consistent with this hypothesis, Dll is necessary for the development of both peripheral and central components of the Drosophila olfactory system...
January 2016: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/26438517/pharmacological-identification-of-cholinergic-receptor-subtypes-on-drosophila-melanogaster-larval-heart
#19
Cole A Malloy, Kyle Ritter, Jonathan Robinson, Connor English, Robin L Cooper
The Drosophila melanogaster heart is a popular model in which to study cardiac physiology and development. Progress has been made in understanding the role of endogenous compounds in regulating cardiac function in this model. It is well characterized that common neurotransmitters act on many peripheral and non-neuronal tissues as they flow through the hemolymph of insects. Many of these neuromodulators, including acetylcholine (ACh), have been shown to act directly on the D. melanogaster larval heart. ACh is a primary neurotransmitter in the central nervous system (CNS) of vertebrates and at the neuromuscular junctions on skeletal and cardiac tissue...
January 2016: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/26410165/pax-transcription-factors-in-neural-crest-development
#20
REVIEW
Anne H Monsoro-Burq
The nine vertebrate PAX transcription factors (PAX1-PAX9) play essential roles during early development and organogenesis. Pax genes were identified in vertebrates using their homology with the Drosophila melanogaster paired gene DNA-binding domain. PAX1-9 functions are largely conserved throughout vertebrate evolution, in particular during central nervous system and neural crest development. The neural crest is a vertebrate invention, which gives rise to numerous derivatives during organogenesis, including neurons and glia of the peripheral nervous system, craniofacial skeleton and mesenchyme, the heart outflow tract, endocrine and pigment cells...
August 2015: Seminars in Cell & Developmental Biology
keyword
keyword
43285
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"