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https://www.readbyqxmd.com/read/28762873/management-of-hot-flushes-in-uk-breast-cancer-patients-clinician-and-patient-perspectives
#1
Deborah Fenlon, Adrienne Morgan, Priya Khambaita, Pankaj Mistry, Janet Dunn, Mei-Lin Ah-See, Emma Pennery, Myra S Hunter
INTRODUCTION: Menopausal problems are among the most prevalent and distressing problems following breast cancer treatment, with 70% women experiencing hot flushes and night sweats (HFNS). A working party was set up to support the development of new research into the management of these problems. METHODS: We conducted surveys to explore the need as perceived by women with breast cancer and establish current UK management practices. A patient survey was conducted through a charity, Breast Cancer Care, and a health professional survey via the UK Breast Intergroup...
August 1, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28760403/health-related-quality-of-life-for-immediate-versus-delayed-androgen-deprivation-therapy-in-patients-with-asymptomatic-non-curable-prostate-cancer-trog-03-06-and-vcog-pr-01-03-toad-a-randomised-multicentre-non-blinded-phase-3-trial
#2
Gillian M Duchesne, Henry H Woo, Madeleine King, Steven J Bowe, Martin R Stockler, Alice Ames, Catherine D'Este, Mark Frydenberg, Andrew Loblaw, Shawn Malone, Jeremy Millar, Keen Hun Tai, Sandra Turner
BACKGROUND: Androgen-deprivation therapy in patients with prostate cancer who have relapsed with rising prostate-specific antigen concentration only (PSA-only relapse), or with non-curable but asymptomatic disease at diagnosis, could adversely affect quality of life at a time when the disease itself does not. We aimed to compare the effect of immediate versus delayed androgen-deprivation therapy on health-related quality of life over 5 years in men enrolled in the TOAD (Timing of Androgen Deprivation) trial...
July 28, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28742263/progesterone-receptor-modulators-for-endometriosis
#3
REVIEW
Jing Fu, Hao Song, Min Zhou, Huili Zhu, Yuhe Wang, Hengxi Chen, Wei Huang
BACKGROUND: Endometriosis is defined as the presence of endometrial tissue (glands and stroma) outside the uterine cavity. This condition is oestrogen-dependent and thus is seen primarily during the reproductive years. Owing to their antiproliferative effects in the endometrium, progesterone receptor modulators (PRMs) have been advocated for treatment of endometriosis. OBJECTIVES: To assess the effectiveness and safety of PRMs primarily in terms of pain relief as compared with other treatments or placebo or no treatment in women of reproductive age with endometriosis...
July 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28737239/long-term-use-of-dienogest-in-the-treatment-of-painful-symptoms-in-adenomyosis
#4
Yutaka Osuga, Manabu Watanabe, Atsushi Hagino
AIM: We aimed to investigate the safety and efficacy of dienogest (DNG), a progestational 19-norsteroid, administered for 52 weeks in patients with symptomatic adenomyosis. METHODS: A total of 130 patients with adenomyosis received 2 mg of DNG orally each day for 52 weeks. In cases of complicated anemia, patients were treated for anemia prior to receiving the medication. Adverse events and adverse drug reactions were evaluated. The patients' pain symptoms (dysmenorrhea and pelvic pain from adenomyosis) were assessed using a pain-scoring tool...
July 24, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28723517/practice-patterns-compared-with-evidence-based-strategies-for-the-management-of-androgen-deprivation-therapy-induced-side-effects-in-prostate-cancer-patients-results-of-a-european-web-based-survey
#5
Renée Bultijnck, Cristian Surcel, Guillaume Ploussard, Alberto Briganti, Pieter De Visschere, Jurgen Fütterer, Pirus Ghadjar, Gianluca Giannarini, Hendrik Isbarn, Christophe Massard, Prasanna Sooriakumaran, Massimo Valerio, Roderick van den Bergh, Piet Ost
BACKGROUND: Evidence-based recommendations are available for the management of androgen deprivation therapy (ADT)-induced side effects; however, there are no data on the implementation of the recommendations into daily practice patterns. OBJECTIVE: To compare practice patterns in the management of ADT-induced side effects with evidence-based strategies. DESIGN, SETTING, AND PARTICIPANTS: A European Web-based survey was conducted from January 16, 2015, to June 24, 2015...
December 2016: European Urology Focus
https://www.readbyqxmd.com/read/28721770/study-to-investigate-how-nurse-led-cbt-can-support-women-with-breast-cancer
#6
(no author information available yet)
Breast care nurses are being trained to offer talking therapy in an effort to improve treatment for hot flushes and night sweats.
July 19, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28707431/efficacy-of-a-proprietary-trigonella-foenum-graecum-l-de-husked-seed-extract-in-reducing-menopausal-symptoms-in-otherwise-healthy-women-a-double-blind-randomized-placebo-controlled-study
#7
E Steels, M L Steele, M Harold, S Coulson
Trigonella foenum-graecum seed extract has demonstrated hormone modulatory activity, providing biological plausibility for relieving menopausal symptoms. The study aimed to assess efficacy of a standardized T. foenum-graecum de-husked seed extract in reducing menopausal symptoms in healthy aging women. The study was a double-blind, randomized, placebo-controlled trial that recruited 115 women aged 40 to 65 years of which 59 were allocated to active (n = 54 completed) and 56 to placebo (n = 50 completed)...
July 14, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28699430/the-hot-flush-symptom-of-menopause-or-sign-of-disease
#8
Rod Baber
No abstract text is available yet for this article.
August 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28691549/factors-associated-with-complementary-and-alternative-medicine-use-among-women-at-midlife
#9
C Costanian, R A G Christensen, H Edgell, C I Ardern, H Tamim
Hormone replacement therapy (HRT) has been established as the first-line treatment for women experiencing menopausal symptoms. The use of complementary and alternative medicine (CAM), however, is becoming increasingly popular among women at midlife for management of such symptoms. Despite the equivocal evidence of CAM's efficacy in the reduction and alleviation of menopausal symptoms in placebo-controlled, randomized trials, 50% of women at midlife use CAM. To date, several large, population-based studies have focused upon CAM use amongst menopausal women and the factors associated with the adoption of such therapies...
July 8, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28677300/a-pill-or-a-patch-for-a-hot-flush
#10
(no author information available yet)
No abstract text is available yet for this article.
July 5, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28654628/hot-flush-frequency-and-severity-at-baseline-as-predictors-of-time-to-transient-and-stable-treatment-success-pooled-analysis-of-two-ce-bza-studies
#11
JoAnn V Pinkerton, Andrew G Bushmakin, Joel Bobula, Joanne Lavenberg, Barry S Komm, Lucy Abraham
OBJECTIVE: To evaluate the impact of baseline hot flush frequency and severity on time to symptom improvement during treatment with conjugated estrogens/bazedoxifene (CE/BZA). METHODS: Data were pooled through week 12 from two randomized placebo-controlled trials (SMART-1 and SMART-2) of nonhysterectomized postmenopausal women with hot flushes treated with CE 0.45 mg/BZA 20 mg or CE 0.625 mg/BZA 20 mg. Time to transient and stable improvement (≥ 50% reduction in hot flush frequency/severity) was estimated using nonparametric models...
June 26, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28649907/non-menopausal-endocrine-and-non-endocrine-causes-of-flushing-and-sweating
#12
Vikram Lal, Yaasir H Mamoojee, Richard Quinton
Hot flushes and generalised sweating are relatively common presenting complaints, with hypogonadism an important differential diagnosis in both sexes and menopause being the most typical cause in females of climacteric age. However, a variety of other conditions do need to be carefully considered in respect of eugonadal individuals and also for those hypogonadal ones where properly dosed sex steroid replacement has failed to control flushing and sweating, or where the presentation is atypical. Alternative aetiologies may be immediately obvious from the history and physical examination, but more unusual conditions may require deeper scrutiny...
January 1, 2017: Post Reproductive Health
https://www.readbyqxmd.com/read/28648407/health-related-quality-of-life-fear-of-recurrence-and-emotional-distress-in-patients-treated-for-thyroid-cancer
#13
S N Rogers, V Mepani, S Jackson, D Lowe
Diagnosis of differentiated thyroid carcinoma (papillary or follicular) and its treatment may be associated with a poor health-related quality of life (HRQoL), and with fear of recurrence (FoR), and distress. To our knowledge, this is the first time a single FoR screening question (written to complement a HRQoL questionnaire), has been reported with HRQoL and levels of distress in patients treated for the disease. In April 2014 we did a cross-sectional survey of patients who had presented to the Merseyside and Cheshire thyroid cancer network between April 2009 and November 2013...
June 22, 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/28609394/evaluation-of-depressive-symptoms-in-mid-aged-women-report-of-a-multicenter-south-american-study
#14
Danny Salazar-Pousada, Alvaro Monterrosa-Castro, Eliana Ojeda, Sandra C Sánchez, Ingrid F Morales-Luna, Faustino R Pérez-López, Peter Chedraui
OBJECTIVE: To evaluate depressive symptoms and related factors among mid-aged women using the 10-item Center for Epidemiologic Studies Depression Scale (CESD-10). METHODS: This was a cross-sectional multicenter study in which women aged 40 to 65 from various South American countries were surveyed with the CESD-10 and a general questionnaire containing personal and partner data. RESULTS: In all, 864 women were interviewed from Colombia (Afro-Colombian, n = 215), Ecuador (Mestizo, n = 202), Perú (Quechua at high altitude, n = 231), and Paraguay (Mestizo, n = 216)...
June 12, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28609387/long-term-sertraline-treatment-and-depression-effects-on-carotid-artery-atherosclerosis-in-premenopausal-female-primates
#15
Marnie G Silverstein-Metzler, Jamie N Justice, Susan E Appt, Leanne Groban, Dalane W Kitzman, John Jeffrey Carr, Thomas C Register, Carol A Shively
OBJECTIVE: Atherosclerosis developed during premenopausal years predicts postmenopausal atherosclerosis burden. Selective serotonin reuptake inhibitor (SSRI) antidepressants, recently approved for hot flushes, have been associated with increased ischemic stroke risk in several observational studies; however, effects on carotid artery atherosclerosis, a strong predictor of future vascular events, are unknown. METHODS: The effects of chronic administration of a commonly prescribed SSRI, sertraline HCl, on atherosclerosis in the carotid artery was assessed in a placebo-controlled, longitudinal, randomized study of premeonopausal depressed and nondepressed cynomolgus monkeys (Macaca fascicularis; n = 42)...
June 12, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28598445/menopausal-health-status-of-nepalese-women
#16
S Rajbhandari, R K Subedi, G Dangal, A Phuyal, A Vaidya, A Karki, H Tuladhar, B S Gurung, L Joshi, S Shrestha
INTRODUCTION: Menopause is an unavoidable and sometimes problematic condition in which women may suffer from a number of health problems. Knowledge of the major symptoms associated with menopause helps reduce the burden and stress associated with the condition. In this context, a study was conducted to establish baseline data regarding menopausal health problems among Nepalese women. METHODS: A descriptive cross-sectional study was conducted among 2000 women aged over 40 years to identify their knowledge, attitude and practice related to menopausal health problems...
January 2017: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/28591133/combined-red-clover-isoflavones-and-probiotics-potently-reduce-menopausal-vasomotor-symptoms
#17
Max Norman Tandrup Lambert, Anne Cathrine Thorup, Esben Søvsø Szoscka Hansen, Per Bendix Jeppesen
BACKGROUND: Natural estrogen decline leads to vasomotor symptoms (VMS). Hormone therapy alleviates symptoms but increases cancer risk. Effective treatments against VMS with minimal cancer risks are needed. We investigate the effects of a highly bioavailable aglycone rich Red Clover isoflavone treatment to alleviate existing menopausal VMS, assessed for the first time by 24hour ambulatory skin conductance (SC). METHODS AND RESULTS: We conducted a parallel, double blind, randomised control trial of 62 peri-menopausal women aged 40-65, reporting ≥ 5 hot flushes/day and follicle stimulating hormone ≥35 IU/L...
2017: PloS One
https://www.readbyqxmd.com/read/28580495/factors-associated-with-sexual-quality-of-life-among-midlife-women-in-serbia
#18
Tatjana Gazibara, Selmina Nurkovic, Nikolina Kovacevic, Ilma Kurtagic, Biljana Rancic, Sanja Radovanovic, Branislav Milosevic, Milan Terzic, Jelena Dotlic
PURPOSE: To assess factors associated with better sexual quality of life (QOL) in midlife period among women who are and are not sexually active. METHODS: Participants were 500 women aged 40-65 years from Belgrade, Serbia. Data were collected through general questionnaire (regarding socio-demographic characteristics, lifestyle habits, general medical, and gynecological history) in which one item investigated having partnered sexual activity (heterosexual intercourses)...
June 3, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28579415/elagolix-for-the-management-of-heavy-menstrual-bleeding-associated-with-uterine-fibroids-results-from-a-phase-2a-proof-of-concept-study
#19
RANDOMIZED CONTROLLED TRIAL
David F Archer, Elizabeth A Stewart, Rita I Jain, Robert A Feldman, Andrea S Lukes, Janine D North, Ahmed M Soliman, Jingjing Gao, Juki W Ng, Kristof Chwalisz
OBJECTIVE: To evaluate the safety and efficacy of elagolix vs. placebo and elagolix with low-dose E2/progestogen add-back therapy. DESIGN: Proof-of-concept, dose-ranging, multiple-cohort study. SETTING: Clinics. PATIENT(S): Premenopausal women with fibroids and heavy menstrual bleeding (menstrual blood loss [MBL] >80 mL per cycle). INTERVENTION(S): Three months' treatment with elagolix alone: 100 mg twice daily (BID), 200 mg BID, 300 mg BID, 400 mg once daily (QD), or 600 mg QD (all but the 600 mg QD arm were placebo controlled); or elagolix plus add-back therapy: 200 mg BID plus continuous low-dose E2 0...
July 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28561959/review-of-efficacy-of-complementary-and-alternative-medicine-treatments-for-menopausal-symptoms
#20
REVIEW
Thea R Moore, Rachel B Franks, Carol Fox
Complementary and alternative medicine (CAM) treatments have been used for thousands of years around the world. There has been increased interest in utilizing CAM for menopausal symptoms since the release of results of the Women's Health Initiative elucidated long-term adverse effects associated with hormone therapy. Women looking for more natural or safer means to treat hot flushes, night sweats, and other menopausal symptoms often turn to CAM such as yoga, phytoestrogens, or black cohosh. Yet there have been few well-conducted studies looking at the efficacy of these treatments...
May 2017: Journal of Midwifery & Women's Health
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