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https://www.readbyqxmd.com/read/28323948/dose-dependent-suppression-of-gonadotropins-and-ovarian-hormones-by-elagolix-in-healthy-premenopausal-women
#1
Juki Ng, Kristof Chwalisz, David C Carter, Cheri E Klein
Context: Elagolix is a nonpeptide, oral gonadotropin-releasing hormone (GnRH) antagonist being developed for sex-hormone dependent diseases in women. Objective: To evaluate the pharmacokinetics and pharmacodynamics of elagolix. Design, Setting, and Participants: Randomized, double-blind, placebo-controlled, multiple-ascending dose study in 45 healthy premenopausal women at a research unit. Interventions: Elagolix 150 mg once daily or 100, 200, 300 or 400 mg twice daily or placebo for 21 days...
February 16, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323626/pomegranate-punica-granatum-seed-oil-for-treating-menopausal-symptoms-an-individually-controlled-cohort-study
#2
Roman Huber, Richard Gminski, Tao Tang, Tomas Weinert, Sabine Schulz, Margareta Linke-Cordes, Ines Martin, Heide Fischer
Context • In the folk medicine of Mediterranean countries and in ancient Ayurveda, Punica granatum seeds (ie, pomegranate seeds) have been used for treatment of various disorders, including those that nowadays are classified as menopausal symptoms (MSs). Pomegranate seed oil (PSO) from those seeds mainly contains unsaturated fatty acids such as γ-linoleic acid and linolenic acid, but it also includes phytoestrogens. It is, therefore, regarded as a promising option for treating MSs today. Objectives • The study intended to investigate the safety and effectiveness of PSO as a defined P granatum seed oil for patients with MSs...
March 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28286984/an-international-menopause-society-study-of-vasomotor-symptoms-in-bangkok-and-chiang-mai-thailand
#3
I Sriprasert, T Pantasri, W Piyamongkol, A Suwan, S Chaikittisilpa, D Sturdee, P Gupta, M S Hunter
OBJECTIVES: To examine relationships between location, demographics, lifestyle, beliefs, and experience of hot flushes and night sweats (HFNS) amongst women living in two cities in Thailand. METHODS: Cross-sectional study of peri- and postmenopausal women, aged 45-55 years, from Bangkok and Chiang Mai. Participants completed questionnaires (demographics, health, HFNS (prevalence, frequency and problem-rating) and beliefs about menopause). A sub-sample of women from each location was interviewed...
April 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28282040/impact-of-water-heater-temperature-setting-and-water-use-frequency-on-the-building-plumbing-microbiome
#4
Pan Ji, William J Rhoads, Marc A Edwards, Amy Pruden
Hot water plumbing is an important conduit of microbes into the indoor environment and can increase risk of opportunistic pathogens (for example, Legionella pneumophila). We examined the combined effects of water heater temperature (39, 42, 48, 51 and 58 °C), pipe orientation (upward/downward), and water use frequency (21, 3 and 1 flush per week) on the microbial composition at the tap using a pilot-scale pipe rig. 16S rRNA gene amplicon sequencing indicated that bulk water and corresponding biofilm typically had distinct taxonomic compositions (R(2)Adonis=0...
March 10, 2017: ISME Journal
https://www.readbyqxmd.com/read/28277870/safety-and-effectiveness-of-tadalafil-in-patients-with-pulmonary-arterial-hypertension-japan-post-marketing-surveillance-data
#5
Hiroyoshi Yamazaki, Noriko Kobayashi, Masanori Taketsuna, Koyuki Tajima, Masahiro Murakami
OBJECTIVE: To evaluate the long-term safety and effectiveness of tadalafil in patients with pulmonary arterial hypertension (PAH) in real-world clinical practice. METHODS: This prospective, multicenter, noninterventional, post-marketing surveillance included patients with PAH who were observed for up to 2 years after initiation of tadalafil. Safety was assessed by analyzing the frequency of adverse drug reactions (ADRs), discontinuations due to adverse events (AEs), and serious adverse drug reactions (SADRs)...
February 21, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28267814/safety-after-extended-repeated-use-of-ulipristal-acetate-for-uterine-fibroids
#6
Bart C J M Fauser, Jacques Donnez, Philippe Bouchard, David H Barlow, Francisco Vázquez, Pablo Arriagada, Sven O Skouby, Santiago Palacios, Janusz Tomaszewski, Boguslaw Lemieszczuk, Alistair R W William
OBJECTIVE: To assess long term safety of extended repeated 3-month courses of ulipristal acetate (UPA) 10 mg/day, for up to 8 courses, with focus on endometrial and laboratory safety parameters. METHODS: This long-term, multi-center, open-label cohort, follow up study consisted of up to 8 consecutive 3-month courses of daily UPA 10 mg, each separated by a drug free period of 2 spontaneous menstrual bleeds. Sixty-four pre-menopausal women, with moderate to severe symptomatic uterine myoma(s) and heavy bleeding were enrolled and were studied for approximately 4 years...
2017: PloS One
https://www.readbyqxmd.com/read/28261572/effect-of-triptorelin-on-lower-urinary-tract-symptoms-in-australian-prostate-cancer-patients
#7
Henry H Woo, Declan G Murphy, Gerard M Testa, Jeremy P Grummet, Michael Chong, Andrew P Stork
PURPOSE: Prostate cancer is often comorbidly associated with lower urinary tract symptoms (LUTS), but few studies have assessed the effects of androgen deprivation therapy on LUTS in this patient group. PATIENTS AND METHODS: We conducted a prospective, noninterventional, multicenter, observational study to assess the effectiveness of triptorelin (11.25 mg every 12 weeks) over 48 weeks in men presenting with local stage T3/4 prostate cancer and moderate to severe LUTS (International Prostate Symptom Score [IPSS] >7) in a routine practice setting in Australia...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28260598/the-efficacy-of-acupuncture-on-menopausal-symptoms-acom-study-protocol-for-a-randomised-study
#8
RANDOMIZED CONTROLLED TRIAL
Kamma Sundgaard Lund, John Brodersen, Volkert Siersma, Frans Boch Waldorff
INTRODUCTION: Around 75% of menopausal women experience hot flushes (HF) and 10-20% of all postmenopausal women find this very distressing. The aim of this study is to evaluate the efficacy of acupuncture on moderate-to-severe menopausal symptoms in general and HF in particular. METHODS: An un-blinded randomised trial (cross-over) with 1:1 allocation to early (intervention) versus late (control) acupuncture. The included women suffer from moderate-to-severe HF and will receive a weekly treatment during five consecutive weeks in the following predefined acupuncture points: CV-3, CV-4, LR-8, SP-6, SP-9...
March 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28241734/tetragonia-tetragonioides-pall-kuntze-protects-estrogen-deficient-rats-against-disturbances-of-energy-and-glucose-metabolism-and-decreases-proinflammatory-cytokines
#9
Jin Ah Ryuk, Byoung-Seob Ko, Hye Won Lee, Da Sol Kim, Suna Kang, Yong Hyen Lee, Sunmin Park
Tetragonia tetragonioides (Pall.) Kuntze (TTK) and JakYakGamCho-Tang (JGT) have been used for improving women's health and treating inflammatory diseases. We determined that the long-term consumption of these herbal extracts alleviates the progression of postmenopausal symptoms in high-fat-diet fed ovariectomized (OVX) rats, and further explored the mechanisms involved. Five groups of OVX rats were fed high fat diets that were supplemented with either 2% dextrin (control), 2% TTK (70% ethanol extract), 2% JGT (water extract), 1% JGT + 1% TTK (JGTT), or 30 µg/kg body weight/day of 17β-estradiol (positive control)...
March 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28195994/an-internet-based-cognitive-behavioral-therapy-for-treatment-induced-menopausal-symptoms-in-breast-cancer-survivors-results-of-a-pilot-study
#10
Vera Atema, Marieke van Leeuwen, Hester S A Oldenburg, Marc van Beurden, Myra S Hunter, Neil K Aaronson
OBJECTIVE: Previous studies demonstrated that a cognitive behavioral therapy (CBT) program delivered in group sessions is effective in alleviating treatment-induced menopausal symptoms in women with breast cancer, but also that in-person CBT is inconvenient for some women and can result in low levels of program compliance. A promising, alternative approach is to use the Internet to make this form of CBT more accessible and feasible for patients. The objective of this study was to evaluate the feasibility and to generate preliminary data on the efficacy of a guided, Internet-based CBT program...
February 13, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28171863/a-retrospective-study-on-the-onset-of-menopause-after-chemotherapy-analysis-of-data-extracted-from-the-jean-perrin-comprehensive-cancer-center-database-concerning-345-young-breast-cancer-patients-diagnosed-between-1994-and-2012
#11
Joyce Dohou, Marie-Ange Mouret-Reynier, Fabrice Kwiatkowski, Marie Arbre, Pauline Herviou, Mélanie Pouget, Catherine Abrial, Frédérique Penault-Llorca
OBJECTIVE: Young breast cancer (BC) patients receiving chemotherapy are at risk of chemotherapy-induced menopause (CIM). We sought to define the incidence rate of premature menopause after chemotherapy and to retrospectively investigate factors related to the onset of menopause. METHODS: We identified BC patients who had received chemotherapy at the Cancer Center (Centre Jean-Perrin). We selected premenopausal women aged between 18 and 50 years at the moment of diagnosis who received chemotherapy between 1994 and 2012...
February 8, 2017: Oncology
https://www.readbyqxmd.com/read/28160855/effects-of-a-standardised-extract-of-trifolium-pratense-promensil-at-a-dosage-of-80mg-in-the-treatment-of-menopausal-hot-flushes-a-systematic-review-and-meta-analysis
#12
S P Myers, V Vigar
OBJECTIVE: To critically assess the evidence for a specific standardised extract of Trifolium pratense isoflavones (Promensil) at a dosage of 80mg/day in the treatment of menopausal hot flushes. DATA SOURCES: Systematic literature searches were performed in Medline, Scopus, CINAHL Plus, Cochrane, AMED and InforRMIT and citations obtained from 1996 to March 2016. Reference lists were checked; corresponding authors contacted and the grey literature searched for additional publications...
January 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28159064/vasomotor-symptoms-and-metabolic-syndrome
#13
REVIEW
Pauliina Tuomikoski, Hanna Savolainen-Peltonen
A vast majority of menopausal women suffer from vasomotor symptoms, such as hot flushes and night sweats, the mean duration of which may be up to 7-10 years. In addition to a decreased quality of life, vasomotor symptoms may have an impact on overall health. Vasomotor symptoms are associated with overactivity of the sympathetic nervous system, and sympathetic overdrive in turn is associated with metabolic syndrome, which is a known risk factor for cardiovascular disease. Menopausal hot flushes have a complex relationship to different features of the metabolic syndrome and not all data point towards an association between vasomotor symptoms and metabolic syndrome...
March 2017: Maturitas
https://www.readbyqxmd.com/read/28132583/the-evolving-role-of-oral-hormonal-therapies-and-review-of-conjugated-estrogens-bazedoxifene-for-the-management-of-menopausal-symptoms
#14
Sharon J Parish, John A Gillespie
This review describes the evolving role of oral hormone therapy (HT) for treating menopausal symptoms and preventing osteoporosis, focusing on conjugated estrogens/bazedoxifene (CE/BZA). Estrogens alleviate hot flushes and prevent bone loss associated with menopause. In nonhysterectomized women, a progestin should be added to estrogens to reduce the risk of endometrial cancer. Use of HT declined since the Women's Health Initiative (WHI) studies showed that HT does not prevent coronary heart disease (CHD) and that conjugated estrogens/medroxyprogesterone acetate increased the risk of invasive breast cancer after nearly 5 years of use...
January 30, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28113032/comparative-efficacy-and-safety-of-adjuvant-letrozole-versus-anastrozole-in-postmenopausal-patients-with-hormone-receptor-positive-node-positive-early-breast-cancer-final-results-of-the-randomized-phase-iii-femara-versus-anastrozole-clinical-evaluation-face
#15
Ian Smith, Denise Yardley, Howard Burris, Richard De Boer, Dino Amadori, Kristi McIntyre, Bent Ejlertsen, Michael Gnant, Walter Jonat, Kathleen I Pritchard, Mitch Dowsett, Lowell Hart, Susan Poggio, Lisa Comarella, Herve Salomon, Barbara Wamil, Joyce O'Shaughnessy
Purpose The Letrozole (Femara) Versus Anastrozole Clinical Evaluation (FACE) study compared the efficacy and safety of adjuvant letrozole versus anastrozole in postmenopausal patients with hormone receptor (HR) -positive and node-positive early breast cancer (eBC). Methods Postmenopausal women with HR-positive and node-positive eBC were randomly assigned to receive adjuvant therapy with either letrozole (2.5 mg) or anastrozole (1 mg) once per day for 5 years or until recurrence of disease. Patients were stratified on the basis of the number of lymph nodes and human epidermal growth factor receptor 2 status...
January 23, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28109283/ethanol-extracted-cameroonian-propolis-exerts-estrogenic-effects-and-alleviates-hot-flushes-in-ovariectomized-wistar-rats
#16
Stéphane Zingue, Chantal Beatrice Magne Nde, Thomas Michel, Derek Tantoh Ndinteh, Jules Tchatchou, Moïse Adamou, Xavier Fernandez, Fernand-Nestor Tchuenguem Fohouo, Colin Clyne, Dieudonné Njamen
BACKGROUND: Since the biological properties of propolis depend to the plants that can be found in a specific region, propolis from unexplored regions attracts the attention of scientists. Ethanolic extract of Cameroonian propolis (EEP) is used to treat various ailments including gynecological problems and amenorrhea. Since there were no scientific data to support the above claims, the present study was therefore undertaken to assess estrogenic properties of Cameroonian propolis. METHODS: To achieve our goal, the ability of EEP to induce MCF-7 cells proliferation in E-screen assay as well as to activate estrogen receptors α (ERα) and β (ERβ) in cell-based reporter gene assays using human embryonic kidney cells (HEK293T) transfected with ERs was tested...
January 21, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28093070/clonidine-is-effective-for-the-treatment-of-primary-idiopathic-hyperhidrosis-and-hot-flushes-a-case-report
#17
Ahmed Albadrani
BACKGROUND: While primary hyperhidrosis can be seen in men, accompanying hot flushes is rarely seen in men. Primary hyperhidrosis is thought to be related to overactivity of the sympathetic nervous system while hot flushes are believed to be related to altered peripheral vascular reactivity and a narrowed thermoregulatory zone. CASE PRESENTATION: I report the case of a 29-year-old man of Arab origin who presented to a dermatology clinic with a complaint of generalized sweating, with heavier involvement of his inguinal region, axilla, and lower back...
January 17, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28078261/effects-of-aqueous-extracts-of-cynanchum-wilfordii-in-rat-models-for-postmenopausal-hot-flush
#18
Gyuok Lee, Chul-Yung Choi, Woojin Jun
Menopausal hot flushes (HFs), which manifest as a transient increase in skin temperature, occur most frequently in postmenopausal women, and sometimes negatively influence daily life. We investigated the effect of an aqueous extract of Cynanchum wilfordii (CWW) in a rat model of menopausal HFs, where tail skin temperature (TST) is increased after the rapid estrogen decline induced by ovariectomy. Ten-week-old female rats were ovariectomized and treated with CWW for 1 week. We measured TST and rectal temperatures (RT) and investigated serum estradiol...
December 2016: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/28042727/new-evidence-for-cardiac-benefit-of-postmenopausal-hormone-therapy
#19
REVIEW
T S Mikkola, H Savolainen-Peltonen, M Venetkoski, O Ylikorkala
Coronary artery disease (CAD) is still the most common killer of western women. Coronary arteries, expressing estrogen receptors, are a target for estrogen action. Prior to the Women's Health Initiative (WHI) study, postmenopausal hormone therapy (HT) was widely advocated for primary prevention of CAD, but such use was criticized after the WHI publication. However, new data accumulated in the USA and in Europe indicate that the use of estradiol-based HT regimens does not endanger the heart, but rather, it significantly reduces the incidence of CAD events and mortality...
February 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28024943/effects-of-ovarian-ablation-or-suppression-in-premenopausal-breast-cancer-a-meta-analysis-of-randomized-controlled-trials
#20
REVIEW
P Zhang, C-Z Li, G-M Jiao, J-J Zhang, H-P Zhao, F Yan, S-F Jia, B-S Hu, C-T Wu
BACKGROUND: The effect of ovarian ablation or suppression (OAS) in premenopausal women with breast cancer is controversial. The overall survival (OS), disease-free survival (DFS) and adverse event of OAS versus no OAS were compared. METHODS: A literature review of EMBASE, Web of Science, PUBMED, and Cochrane Library was conducted. The hazard ratio (HR) and 95% confidence interval (CI) for OS and DFS, as well as risk ratio (RR) and 95% CI for adverse events were evaluated...
December 5, 2016: European Journal of Surgical Oncology
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