keyword
MENU ▼
Read by QxMD icon Read
search

Hot flush

keyword
https://www.readbyqxmd.com/read/27908454/fulvestrant-500-mg-versus-anastrozole-1-mg-for-hormone-receptor-positive-advanced-breast-cancer-falcon-an-international-randomised-double-blind-phase-3-trial
#1
John F R Robertson, Igor M Bondarenko, Ekaterina Trishkina, Mikhail Dvorkin, Lawrence Panasci, Alexey Manikhas, Yaroslav Shparyk, Servando Cardona-Huerta, Kwok-Leung Cheung, Manuel Jesus Philco-Salas, Manuel Ruiz-Borrego, Zhimin Shao, Shinzaburo Noguchi, Jacqui Rowbottom, Mary Stuart, Lynda M Grinsted, Mehdi Fazal, Matthew J Ellis
BACKGROUND: Aromatase inhibitors are a standard of care for hormone receptor-positive locally advanced or metastatic breast cancer. We investigated whether the selective oestrogen receptor degrader fulvestrant could improve progression-free survival compared with anastrozole in postmenopausal patients who had not received previous endocrine therapy. METHODS: In this phase 3, randomised, double-blind trial, we recruited eligible patients with histologically confirmed oestrogen receptor-positive or progesterone receptor-positive, or both, locally advanced or metastatic breast cancer from 113 academic hospitals and community centres in 20 countries...
November 28, 2016: Lancet
https://www.readbyqxmd.com/read/27887581/design-of-a-randomized-controlled-trial-of-internet-based-cognitive-behavioral-therapy-for-treatment-induced-menopausal-symptoms-in-breast-cancer-survivors
#2
Vera Atema, Marieke van Leeuwen, Hester S A Oldenburg, Valesca Retèl, Marc van Beurden, Myra S Hunter, Neil K Aaronson
BACKGROUND: Menopausal symptoms are common and may be particularly severe in younger women who undergo treatment-induced menopause. Medications to reduce menopausal symptoms are either contra-indicated or have bothersome side effects. Previous studies have demonstrated that face-to-face cognitive behavioral therapy (CBT) is effective in alleviating menopausal symptoms in women with breast cancer. However, compliance with face-to-face CBT programs can be problematic. A promising approach is to use the Internet to make this form of CBT more accessible and feasible for patients...
November 25, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27865514/coagulase-negative-staphylococcus-species-in-bulk-milk-prevalence-distribution-and-associated-subgroup-and-species-specific-risk-factors
#3
A De Visscher, S Piepers, F Haesebrouck, K Supré, S De Vliegher
Coagulase-negative staphylococci (CNS) have become the main pathogens causing bovine mastitis in recent years. A huge variation in species distribution among herds has been observed in several studies, emphasizing the need to identify subgroup- and species-specific herd-level factors to improve our understanding of the differences in ecological and epidemiological nature between species. The use of bulk milk samples enables the inclusion of a large(r) number of herds needed to identify herd-level risk factors and increases the likelihood of recovering enough isolates per species needed for conducting subgroup- and, eventually, species-specific analyses at the same time...
November 16, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27845857/effects-of-imparting-planned-health-education-on-hot-flush-beliefs-and-quality-of-life-of-climacteric-women
#4
A Sis Çelik, T Pasinlioğlu
OBJECTIVE: The aim of the present study was to determine the effect of imparting planned health education to climacteric women on their beliefs related to hot flushes and on their quality of life. METHODS: The research was conducted using pretest and post-test semi-experimental models along with a control group. Of 450 women, 255 were randomly selected and invited to participate in the study. Five people did not agree to participate in the study. Three people were also excluded from the study because they did not complete training...
November 15, 2016: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/27836000/unusual-side-effect-from-a-luteinizing-hormone-releasing-hormone-agonist-leuprorelin-in-the-treatment-of-prostate-cancer-a-case-report
#5
John I-Chiang Chang, Joseph Bucci
BACKGROUND: The treatment options for high-risk prostate cancer are either radical prostatectomy or radiotherapy/brachytherapy depending on the patients' prognosis. In older men with multiple comorbidities, radiotherapy with androgen deprivation therapy is an attractive option. Common side effects of androgen deprivation therapy include hot flushes, tiredness, increased risk of fractures, increased risk of metabolic disorders, coronary heart disease, and psychological effects. This case highlights the potential side effect of lipodystrophy secondary to leuprolide acetate injections...
November 11, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27832718/mind-body-interventions-for-vasomotor-symptoms-in-healthy-menopausal-women-and-breast-cancer-survivors-a-systematic-review
#6
Evgenia Stefanopoulou, Elizabeth Alice Grunfeld
Mind-body therapies are commonly recommended to treat vasomotor symptoms, such as hot flushes and night sweats (HFNS). The purpose of this systematic review was to evaluate the available evidence to date for the efficacy of different mind-body therapies to alleviate HFNS in healthy menopausal women and breast cancer survivors. Randomized controlled trials (RCTs) were identified using seven electronic search engines, direct searches of specific journals and backwards searches through reference lists of related publications...
November 11, 2016: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27823739/direct-and-indirect-effects-of-conjugated-estrogens-bazedoxifene-treatment-on-quality-of-life-in-postmenopausal-women
#7
Lucy Abraham, Andrew G Bushmakin, Erika Dragon, Barry S Komm, JoAnn V Pinkerton
OBJECTIVE: Determine the direct and indirect effects of conjugated estrogens/bazedoxifene (CE/BZA) treatment on menopause-specific quality of life in a post-hoc analysis of 2 phase 3 Selective estrogens, Menopause, And Response to Therapy (SMART-1, SMART-2) trials. STUDY DESIGN: Data from participants in SMART-1 and SMART-2 who received CE 0.45mg/BZA 20mg, CE 0.625mg/BZA 20mg, or placebo were analyzed, including week 12 data from 1274 healthy postmenopausal women in SMART-1 and pooled week 1-4 and 9-12 data from 332 women with moderate to severe vasomotor symptoms (≥7 HFs/d or ≥50/wk) in SMART-2...
December 2016: Maturitas
https://www.readbyqxmd.com/read/27797974/significant-effect-of-polymorphisms-in-cyp2d6-on-response-to-tamoxifen-therapy-for-breast-cancer-a-prospective-multicenter-study
#8
Hitoshi Zembutsu, Seigo Nakamura, Sadako Tanaka Akashi, Takashi Kuwayama, Chie Watanabe, Tomoko Takamaru, Hiroyuki Takei, Takashi Ishikawa, Kana Miyahara, Hiroshi Matsumoto, Yoshie Hasegawa, Goro Kutomi, Hiroaki Shima, Fukino Satomi, Minoru Okazaki, Hisamitsu Zaha, Mai Onomura, Ayami Matsukata, Yasuaki Sagara, Shinichi Baba, Akimitsu Yamada, Kazuhiro Shimada, Daisuke Shimizu, Koichiro Tsugawa, Arata Shimo, Ern-Yu Tan, Mikael Hartman, Ching-Wan Chan, Soo-Chin Lee, Yusuke Nakamura
PURPOSE: CYP2D6 is the key enzyme responsible for the generation of the potent active metabolite of tamoxifen, "endoxifen". There are still controversial reports questioning the association between CYP2D6 genotype and tamoxifen efficacy. Hence, we performed a prospective multicenter study to evaluate the clinical effect of CYP2D6 genotype on tamoxifen therapy. EXPERIMENTAL DESIGN: We enrolled 279 patients with hormone receptor-positive and human epidermal growth factor receptor 2-negative, invasive breast cancer receiving pre-operative tamoxifen monotherapy for 14-28 days...
October 19, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27784319/estrogenic-and-cytotoxic-potentials-of-compounds-isolated-from-millettia-macrophylla-benth-fabaceae-towards-a-better-understanding-of-its-underlying-mechanisms
#9
Stéphane Zingue, Job Tchoumtchoua, Dieudonnée Mireille Ntsa, Louis Pergaud Sandjo, Julia Cisilotto, Chantal Beatrice Magne Nde, Evelyn Winter, Charline Florence Awounfack, Derek Tantoh Ndinteh, Colin Clyne, Dieudonné Njamen, Maria Halabalaki, Tânia Beatriz Creczynski-Pasa
BACKGROUND: Millettia macrophylla was previously reported to have estrogenic effects and to prevent postmenopausal osteoporosis in Wistar rats. So, the study deals with the identification of its secondary metabolites and the evaluation of their estrogenicity and cytotoxicity toward tumoural cells. Thus, 13 known compounds were obtained from successive chromatographic columns and identified by NMR data compared to those previously reported. METHODS: In vitro estrogenicity of the isolates and the phenolic fraction (PF) of M...
October 26, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27781103/ageing-and-menopause-considerations-for-women-with-hiv-in-the-uk
#10
EDITORIAL
L Sherr, A Molloy, A Macedo, N Croome, M A Johnson
OBJECTIVES: Treatment rollout has dramatically improved life expectancy for people with HIV and AIDS. Women represent a substantial proportion of patients in the UK (approximately one-third of patients in care are female according to the HIV Annual Report 2014). This study examines psychosocial and biomedical issues for women diagnosed with HIV in the UK, comparing those above and below 45 years of age to examine menopause and ageing issues. METHODS: Consecutive clinic attenders in a large outpatient London HIV clinic were invited to participate in the study...
October 5, 2016: Journal of Virus Eradication
https://www.readbyqxmd.com/read/27763802/a-randomized-double-blind-placebo-controlled-trial-of-schisandra-chinensis-for-menopausal-symptoms
#11
J Y Park, K H Kim
OBJECTIVES: The purpose of this clinical trial was to evaluate the effectiveness of a natural extract from Schisandra chinensis for relief of various menopausal symptoms. METHODS: A randomized, double-blind, placebo-controlled clinical trial was conducted from January 1, 2014 until January 13, 2015. We recruited women between the ages of 40 and 70 years who complained of menopausal symptoms measured by the Kupperman Index (KI). Patients were randomly assigned to treatment with either an extract from Schisandra chinensis (BMO-30) or placebo...
October 20, 2016: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/27763798/a-negative-view-of-menopause-does-the-type-of-symptom-matter
#12
R Sood, C Kuhle, E Kapoor, J Rullo, J Thielen, K Frohmader, K Mara, D Schroeder, S Faubion
OBJECTIVES: To assess the association between the type of symptom and women's self-reported view of menopause. METHODS: The study was conducted at Mayo Clinic, Rochester MN, between January 2006 and October 2014. Women aged 40-64 were included. Data from 1420 women were analyzed in a cross-sectional design. The Menopause Health Questionnaire was used for symptom assessment. Odds ratios (ORs) and population attributable risk (PAR) (OR × percent frequency) were calculated for each symptom...
October 20, 2016: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/27753182/quality-of-life-outcomes-from-the-prostate-adenocarcinoma-transcutaneous-hormones-patch-trial-evaluating-luteinising-hormone-releasing-hormone-agonists-versus-transdermal-oestradiol-for-androgen-suppression-in-advanced-prostate-cancer
#13
Duncan C Gilbert, Trinh Duong, Howard G Kynaston, Abdulla A Alhasso, Fay H Cafferty, Stuart D Rosen, Subramanian Kanaga-Sundaram, Sanjay Dixit, Marc Laniado, Sanjeev Madaan, Gerald Collins, Alvan Pope, Andrew Welland, Matthew Nankivell, Richard Wassersug, Mahesh K B Parmar, Ruth E Langley, Paul D Abel
OBJECTIVES: To compare quality-of-life (QoL) outcomes at 6 months between men with advanced prostate cancer receiving either transdermal oestradiol (tE2) or luteinising hormone-releasing hormone agonists (LHRHa) for androgen-deprivation therapy (ADT). PATIENTS AND METHODS: Men with locally advanced or metastatic prostate cancer participating in an ongoing randomised, multicentre UK trial comparing tE2 versus LHRHa for ADT were enrolled into a QoL sub-study. tE2 was delivered via three or four transcutaneous patches containing oestradiol 100 μg/24 h...
October 18, 2016: BJU International
https://www.readbyqxmd.com/read/27747478/patient-reported-outcomes-pro-focused-on-adverse-events-pro-aes-in-adjuvant-and-metastatic-breast-cancer-clinical-and-translational-implications
#14
Stefan Stefanovic, Markus Wallwiener, Uros Karic, Christoph Domschke, Luka Katic, Florin-Andrei Taran, Aleksandra Pesic, Andreas Hartkopf, Peyman Hadji, Martin Teufel, Florian Schuetz, Christof Sohn, Peter Fasching, Andreas Schneeweiss, Sara Brucker
PURPOSE: The capture of adequate treatment outcomes and quality of life (QOL) of advanced breast cancer patients in clinical routine represents a great challenge. Patient-reported outcomes (PROs) are data elements directly reported by patients about experiences with care, including symptoms, functional status, or quality of life. There is growing interest in the medical community for the evaluation and implementation of PROs of adverse events (PRO-AEs). Recent interest in PROs in health care has evolved in the context of patient centeredness...
October 17, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27737513/pharmacologic-interventions-for-treating-phantom-limb-pain
#15
REVIEW
Maria Jenelyn M Alviar, Tom Hale, Monalisa Dungca
BACKGROUND: This is an updated version of the original Cochrane review published in Issue 12, 2011. Phantom limb pain (PLP) is pain that arises in the missing limb after amputation and can be severe, intractable, and disabling. Various medications have been studied in the treatment of phantom pain. There is currently uncertainty in the optimal pharmacologic management of PLP. OBJECTIVES: This review aimed to summarise the evidence of effectiveness of pharmacologic interventions in treating PLP...
October 14, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27727479/concurrent-salinization-and-development-of%C3%A2-anoxic-conditions-in-a-confined-aquifer-southern-israel
#16
Avihu Burg, Ittai Gavrieli, Joseph Guttman
An ancient, brackish, anoxic, and relatively hot water body exists within the Yarqon-Tanninim Aquifer in southern Israel. A hydrogeological-geochemical conceptual model is presented, whereby the low water quality is the outcome of three conditions that are met simultaneously: (1) Presence of an organic-rich unit with low permeability that overlies and confines the aquifer; the confining unit contains perched horizons with relatively saline water. (2) Local phreatic/roofed conditions within the aquifer that enable seepage of the organic-rich brackish water from above...
October 11, 2016: Ground Water
https://www.readbyqxmd.com/read/27726215/factors-associated-with-current-and-severe-physical-side-effects-after-prostate-cancer-treatment-what-men-report
#17
L Steentjes, S Siesling, F J Drummond, J G van Manen, L Sharp, A Gavin
We identified patient and disease characteristics associated with (1) "current" physical side-effects of any severity; and (2) "severe" physical side-effects "ever" experienced by 3,348 (54%) prostate cancer (PCa) survivors in Ireland diagnosed 2-18 years previously. Postal questionnaires collected symptoms at diagnosis, post-biopsy complications, comorbidities, primary treatments and physical side-effects post-treatment (urinary incontinence, erectile dysfunction, libido loss, bowel problems, breast changes, hot flushes, and fatigue, "ever" and "current" at time of questionnaire completion)...
October 10, 2016: European Journal of Cancer Care
https://www.readbyqxmd.com/read/27723080/the-potential-health-effects-of-dietary-phytoestrogens
#18
REVIEW
Ivonne M C M Rietjens, Jochem Louisse, Karsten Beekmann
Phytoestrogens are plant-derived dietary compounds with structural similarity to 17-β-oestradiol (E2), the primary female sex hormone. This structural similarity to E2 enables phytoestrogens to cause (anti)oestrogenic effects by binding to the oestrogen receptors. The aim of the present review is to present a state-of-the-art overview of the potential health effects of dietary phytoestrogens. Various beneficial health effects have been ascribed to phytoestrogens, such as a lowered risk of menopausal symptoms like hot flushes and osteoporosis, lowered risks of cardiovascular disease, obesity, metabolic syndrome and type 2 diabetes, brain function disorders, breast cancer, prostate cancer, bowel cancer and other cancers...
October 9, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27719781/a-nonhormonal-treatment-for-moderate-to-severe-vasomotor-symptoms-of-menopause
#19
Heidi Collins Fantasia
It is estimated that up to 80% of women experience symptoms related to declining estrogen levels that occur with menopause. The most common bothersome symptoms reported by women during and after this transition are vasomotor symptoms, which can include hot flashes, flushing, night sweats, and sleep disturbances. These symptoms are the most common reason women seek care during menopause. Until recently, the mainstay of treatment and symptom relief has been estrogen supplementation. In 2013, the U.S. Food and Drug Administration approved paroxetine, a low-dose selective serotonin reuptake inhibitor, as the first nonhormonal treatment for moderate to severe vasomotor symptoms of menopause...
October 2016: Nursing for Women's Health
https://www.readbyqxmd.com/read/27696495/quality-of-life-decrements-in-men-with-prostate-cancer-undergoing-androgen-deprivation-therapy
#20
Ada S Cheung, Casey de Rooy, Rudolf Hoermann, Daryl Lim Joon, Jeffrey D Zajac, Mathis Grossmann
OBJECTIVE: While androgen deprivation therapy (ADT) has been associated with decreased quality of life (QoL), controlled prospective studies are lacking. We aimed to assess QoL during ADT using two validated questionnaires and determine contributing factors. DESIGN: Prospective controlled study. PATIENTS: Sixty-three men with nonmetastatic prostate cancer newly commencing ADT (n = 34) and age- and radiotherapy-matched prostate cancer controls (n = 29)...
October 3, 2016: Clinical Endocrinology
keyword
keyword
43281
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"