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https://www.readbyqxmd.com/read/28078261/effects-of-aqueous-extracts-of-cynanchum-wilfordii-in-rat-models-for-postmenopausal-hot-flush
#1
Gyuok Lee, Chul-Yung Choi, Woojin Jun
Menopausal hot flushes (HFs), which manifest as a transient increase in skin temperature, occur most frequently in postmenopausal women, and sometimes negatively influence daily life. We investigated the effect of an aqueous extract of Cynanchum wilfordii (CWW) in a rat model of menopausal HFs, where tail skin temperature (TST) is increased after the rapid estrogen decline induced by ovariectomy. Ten-week-old female rats were ovariectomized and treated with CWW for 1 week. We measured TST and rectal temperatures (RT) and investigated serum estradiol...
December 2016: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/28042727/new-evidence-for-cardiac-benefit-of-postmenopausal-hormone-therapy
#2
T S Mikkola, H Savolainen-Peltonen, M Venetkoski, O Ylikorkala
Coronary artery disease (CAD) is still the most common killer of western women. Coronary arteries, expressing estrogen receptors, are a target for estrogen action. Prior to the Women's Health Initiative (WHI) study, postmenopausal hormone therapy (HT) was widely advocated for primary prevention of CAD, but such use was criticized after the WHI publication. However, new data accumulated in the USA and in Europe indicate that the use of estradiol-based HT regimens does not endanger the heart, but rather, it significantly reduces the incidence of CAD events and mortality...
January 2, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28024943/effects-of-ovarian-ablation-or-suppression-in-premenopausal-breast-cancer-a-meta-analysis-of-randomized-controlled-trials
#3
REVIEW
P Zhang, C-Z Li, G-M Jiao, J-J Zhang, H-P Zhao, F Yan, S-F Jia, B-S Hu, C-T Wu
BACKGROUND: The effect of ovarian ablation or suppression (OAS) in premenopausal women with breast cancer is controversial. The overall survival (OS), disease-free survival (DFS) and adverse event of OAS versus no OAS were compared. METHODS: A literature review of EMBASE, Web of Science, PUBMED, and Cochrane Library was conducted. The hazard ratio (HR) and 95% confidence interval (CI) for OS and DFS, as well as risk ratio (RR) and 95% CI for adverse events were evaluated...
December 5, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28000061/depression-during-the-menopause-transition-impact-on-quality-of-life-social-adjustment-and-disability
#4
Bathsheba A Wariso, Gioia M Guerrieri, Karla Thompson, Deloris E Koziol, Nazli Haq, Pedro E Martinez, David R Rubinow, Peter J Schmidt
The impact of depression on quality of life (QOL) and social support has neither been well characterized in clinical samples of women with perimenopausal depression (PMD) nor have the relative contributions of depression and other menopausal symptoms (e.g., hot flushes) to declining QOL been clarified. In this study, we compared QOL measures, social support, and functional disability in PMD and non-depressed perimenopausal women. We evaluated women aged 40-60 years who presented with menstrual cycle irregularity, elevated plasma FSH levels, and met criteria for perimenopause...
December 21, 2016: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/27908454/fulvestrant-500-mg-versus-anastrozole-1-mg-for-hormone-receptor-positive-advanced-breast-cancer-falcon-an-international-randomised-double-blind-phase-3-trial
#5
John F R Robertson, Igor M Bondarenko, Ekaterina Trishkina, Mikhail Dvorkin, Lawrence Panasci, Alexey Manikhas, Yaroslav Shparyk, Servando Cardona-Huerta, Kwok-Leung Cheung, Manuel Jesus Philco-Salas, Manuel Ruiz-Borrego, Zhimin Shao, Shinzaburo Noguchi, Jacqui Rowbottom, Mary Stuart, Lynda M Grinsted, Mehdi Fazal, Matthew J Ellis
BACKGROUND: Aromatase inhibitors are a standard of care for hormone receptor-positive locally advanced or metastatic breast cancer. We investigated whether the selective oestrogen receptor degrader fulvestrant could improve progression-free survival compared with anastrozole in postmenopausal patients who had not received previous endocrine therapy. METHODS: In this phase 3, randomised, double-blind trial, we recruited eligible patients with histologically confirmed oestrogen receptor-positive or progesterone receptor-positive, or both, locally advanced or metastatic breast cancer from 113 academic hospitals and community centres in 20 countries...
December 17, 2017: Lancet
https://www.readbyqxmd.com/read/27887581/design-of-a-randomized-controlled-trial-of-internet-based-cognitive-behavioral-therapy-for-treatment-induced-menopausal-symptoms-in-breast-cancer-survivors
#6
Vera Atema, Marieke van Leeuwen, Hester S A Oldenburg, Valesca Retèl, Marc van Beurden, Myra S Hunter, Neil K Aaronson
BACKGROUND: Menopausal symptoms are common and may be particularly severe in younger women who undergo treatment-induced menopause. Medications to reduce menopausal symptoms are either contra-indicated or have bothersome side effects. Previous studies have demonstrated that face-to-face cognitive behavioral therapy (CBT) is effective in alleviating menopausal symptoms in women with breast cancer. However, compliance with face-to-face CBT programs can be problematic. A promising approach is to use the Internet to make this form of CBT more accessible and feasible for patients...
November 25, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27865514/coagulase-negative-staphylococcus-species-in-bulk-milk-prevalence-distribution-and-associated-subgroup-and-species-specific-risk-factors
#7
A De Visscher, S Piepers, F Haesebrouck, K Supré, S De Vliegher
Coagulase-negative staphylococci (CNS) have become the main pathogens causing bovine mastitis in recent years. A huge variation in species distribution among herds has been observed in several studies, emphasizing the need to identify subgroup- and species-specific herd-level factors to improve our understanding of the differences in ecological and epidemiological nature between species. The use of bulk milk samples enables the inclusion of a large(r) number of herds needed to identify herd-level risk factors and increases the likelihood of recovering enough isolates per species needed for conducting subgroup- and, eventually, species-specific analyses at the same time...
January 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/27845857/effects-of-imparting-planned-health-education-on-hot-flush-beliefs-and-quality-of-life-of-climacteric-women
#8
A Sis Çelik, T Pasinlioğlu
OBJECTIVE: The aim of the present study was to determine the effect of imparting planned health education to climacteric women on their beliefs related to hot flushes and on their quality of life. METHODS: The research was conducted using pretest and post-test semi-experimental models along with a control group. Of 450 women, 255 were randomly selected and invited to participate in the study. Five people did not agree to participate in the study. Three people were also excluded from the study because they did not complete training...
November 15, 2016: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/27836000/unusual-side-effect-from-a-luteinizing-hormone-releasing-hormone-agonist-leuprorelin-in-the-treatment-of-prostate-cancer-a-case-report
#9
John I-Chiang Chang, Joseph Bucci
BACKGROUND: The treatment options for high-risk prostate cancer are either radical prostatectomy or radiotherapy/brachytherapy depending on the patients' prognosis. In older men with multiple comorbidities, radiotherapy with androgen deprivation therapy is an attractive option. Common side effects of androgen deprivation therapy include hot flushes, tiredness, increased risk of fractures, increased risk of metabolic disorders, coronary heart disease, and psychological effects. This case highlights the potential side effect of lipodystrophy secondary to leuprolide acetate injections...
November 11, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27832718/mind-body-interventions-for-vasomotor-symptoms-in-healthy-menopausal-women-and-breast-cancer-survivors-a-systematic-review
#10
Evgenia Stefanopoulou, Elizabeth Alice Grunfeld
Mind-body therapies are commonly recommended to treat vasomotor symptoms, such as hot flushes and night sweats (HFNS). The purpose of this systematic review was to evaluate the available evidence to date for the efficacy of different mind-body therapies to alleviate HFNS in healthy menopausal women and breast cancer survivors. Randomized controlled trials (RCTs) were identified using seven electronic search engines, direct searches of specific journals and backwards searches through reference lists of related publications...
November 11, 2016: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27823739/direct-and-indirect-effects-of-conjugated-estrogens-bazedoxifene-treatment-on-quality-of-life-in-postmenopausal-women
#11
Lucy Abraham, Andrew G Bushmakin, Erika Dragon, Barry S Komm, JoAnn V Pinkerton
OBJECTIVE: Determine the direct and indirect effects of conjugated estrogens/bazedoxifene (CE/BZA) treatment on menopause-specific quality of life in a post-hoc analysis of 2 phase 3 Selective estrogens, Menopause, And Response to Therapy (SMART-1, SMART-2) trials. STUDY DESIGN: Data from participants in SMART-1 and SMART-2 who received CE 0.45mg/BZA 20mg, CE 0.625mg/BZA 20mg, or placebo were analyzed, including week 12 data from 1274 healthy postmenopausal women in SMART-1 and pooled week 1-4 and 9-12 data from 332 women with moderate to severe vasomotor symptoms (≥7 HFs/d or ≥50/wk) in SMART-2...
December 2016: Maturitas
https://www.readbyqxmd.com/read/27797974/significant-effect-of-polymorphisms-in-cyp2d6-on-response-to-tamoxifen-therapy-for-breast-cancer-a-prospective-multicenter-study
#12
Hitoshi Zembutsu, Seigo Nakamura, Sadako Tanaka Akashi, Takashi Kuwayama, Chie Watanabe, Tomoko Takamaru, Hiroyuki Takei, Takashi Ishikawa, Kana Miyahara, Hiroshi Matsumoto, Yoshie Hasegawa, Goro Kutomi, Hiroaki Shima, Fukino Satomi, Minoru Okazaki, Hisamitsu Zaha, Mai Onomura, Ayami Matsukata, Yasuaki Sagara, Shinichi Baba, Akimitsu Yamada, Kazuhiro Shimada, Daisuke Shimizu, Koichiro Tsugawa, Arata Shimo, Ern-Yu Tan, Mikael Hartman, Ching-Wan Chan, Soo-Chin Lee, Yusuke Nakamura
PURPOSE: CYP2D6 is the key enzyme responsible for the generation of the potent active metabolite of tamoxifen, "endoxifen". There are still controversial reports questioning the association between CYP2D6 genotype and tamoxifen efficacy. Hence, we performed a prospective multicenter study to evaluate the clinical effect of CYP2D6 genotype on tamoxifen therapy. EXPERIMENTAL DESIGN: We enrolled 279 patients with hormone receptor-positive and human epidermal growth factor receptor 2-negative, invasive breast cancer receiving pre-operative tamoxifen monotherapy for 14-28 days...
October 19, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27784319/estrogenic-and-cytotoxic-potentials-of-compounds-isolated-from-millettia-macrophylla-benth-fabaceae-towards-a-better-understanding-of-its-underlying-mechanisms
#13
Stéphane Zingue, Job Tchoumtchoua, Dieudonnée Mireille Ntsa, Louis Pergaud Sandjo, Julia Cisilotto, Chantal Beatrice Magne Nde, Evelyn Winter, Charline Florence Awounfack, Derek Tantoh Ndinteh, Colin Clyne, Dieudonné Njamen, Maria Halabalaki, Tânia Beatriz Creczynski-Pasa
BACKGROUND: Millettia macrophylla was previously reported to have estrogenic effects and to prevent postmenopausal osteoporosis in Wistar rats. So, the study deals with the identification of its secondary metabolites and the evaluation of their estrogenicity and cytotoxicity toward tumoural cells. Thus, 13 known compounds were obtained from successive chromatographic columns and identified by NMR data compared to those previously reported. METHODS: In vitro estrogenicity of the isolates and the phenolic fraction (PF) of M...
October 26, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27781103/ageing-and-menopause-considerations-for-women-with-hiv-in-the-uk
#14
EDITORIAL
L Sherr, A Molloy, A Macedo, N Croome, M A Johnson
OBJECTIVES: Treatment rollout has dramatically improved life expectancy for people with HIV and AIDS. Women represent a substantial proportion of patients in the UK (approximately one-third of patients in care are female according to the HIV Annual Report 2014). This study examines psychosocial and biomedical issues for women diagnosed with HIV in the UK, comparing those above and below 45 years of age to examine menopause and ageing issues. METHODS: Consecutive clinic attenders in a large outpatient London HIV clinic were invited to participate in the study...
October 5, 2016: Journal of Virus Eradication
https://www.readbyqxmd.com/read/27763802/a-randomized-double-blind-placebo-controlled-trial-of-schisandra-chinensis-for-menopausal-symptoms
#15
J Y Park, K H Kim
OBJECTIVES: The purpose of this clinical trial was to evaluate the effectiveness of a natural extract from Schisandra chinensis for relief of various menopausal symptoms. METHODS: A randomized, double-blind, placebo-controlled clinical trial was conducted from January 1, 2014 until January 13, 2015. We recruited women between the ages of 40 and 70 years who complained of menopausal symptoms measured by the Kupperman Index (KI). Patients were randomly assigned to treatment with either an extract from Schisandra chinensis (BMO-30) or placebo...
October 20, 2016: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/27763798/a-negative-view-of-menopause-does-the-type-of-symptom-matter
#16
R Sood, C Kuhle, E Kapoor, J Rullo, J Thielen, K Frohmader, K Mara, D Schroeder, S Faubion
OBJECTIVES: To assess the association between the type of symptom and women's self-reported view of menopause. METHODS: The study was conducted at Mayo Clinic, Rochester MN, between January 2006 and October 2014. Women aged 40-64 were included. Data from 1420 women were analyzed in a cross-sectional design. The Menopause Health Questionnaire was used for symptom assessment. Odds ratios (ORs) and population attributable risk (PAR) (OR × percent frequency) were calculated for each symptom...
October 20, 2016: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/27753182/quality-of-life-outcomes-from-the-prostate-adenocarcinoma-transcutaneous-hormones-patch-trial-evaluating-luteinising-hormone-releasing-hormone-agonists-versus-transdermal-oestradiol-for-androgen-suppression-in-advanced-prostate-cancer
#17
Duncan C Gilbert, Trinh Duong, Howard G Kynaston, Abdulla A Alhasso, Fay H Cafferty, Stuart D Rosen, Subramanian Kanaga-Sundaram, Sanjay Dixit, Marc Laniado, Sanjeev Madaan, Gerald Collins, Alvan Pope, Andrew Welland, Matthew Nankivell, Richard Wassersug, Mahesh K B Parmar, Ruth E Langley, Paul D Abel
OBJECTIVES: To compare quality-of-life (QoL) outcomes at 6 months between men with advanced prostate cancer receiving either transdermal oestradiol (tE2) or luteinising hormone-releasing hormone agonists (LHRHa) for androgen-deprivation therapy (ADT). PATIENTS AND METHODS: Men with locally advanced or metastatic prostate cancer participating in an ongoing randomised, multicentre UK trial comparing tE2 versus LHRHa for ADT were enrolled into a QoL sub-study. tE2 was delivered via three or four transcutaneous patches containing oestradiol 100 μg/24 h...
October 18, 2016: BJU International
https://www.readbyqxmd.com/read/27747478/patient-reported-outcomes-pro-focused-on-adverse-events-pro-aes-in-adjuvant-and-metastatic-breast-cancer-clinical-and-translational-implications
#18
Stefan Stefanovic, Markus Wallwiener, Uros Karic, Christoph Domschke, Luka Katic, Florin-Andrei Taran, Aleksandra Pesic, Andreas Hartkopf, Peyman Hadji, Martin Teufel, Florian Schuetz, Christof Sohn, Peter Fasching, Andreas Schneeweiss, Sara Brucker
PURPOSE: The capture of adequate treatment outcomes and quality of life (QOL) of advanced breast cancer patients in clinical routine represents a great challenge. Patient-reported outcomes (PROs) are data elements directly reported by patients about experiences with care, including symptoms, functional status, or quality of life. There is growing interest in the medical community for the evaluation and implementation of PROs of adverse events (PRO-AEs). Recent interest in PROs in health care has evolved in the context of patient centeredness...
February 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27737513/pharmacologic-interventions-for-treating-phantom-limb-pain
#19
REVIEW
Maria Jenelyn M Alviar, Tom Hale, Monalisa Dungca
BACKGROUND: This is an updated version of the original Cochrane review published in Issue 12, 2011. Phantom limb pain (PLP) is pain that arises in the missing limb after amputation and can be severe, intractable, and disabling. Various medications have been studied in the treatment of phantom pain. There is currently uncertainty in the optimal pharmacologic management of PLP. OBJECTIVES: This review aimed to summarise the evidence of effectiveness of pharmacologic interventions in treating PLP...
October 14, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27727479/concurrent-salinization-and-development-of%C3%A2-anoxic-conditions-in-a-confined-aquifer-southern-israel
#20
Avihu Burg, Ittai Gavrieli, Joseph Guttman
An ancient, brackish, anoxic, and relatively hot water body exists within the Yarqon-Tanninim Aquifer in southern Israel. A hydrogeological-geochemical conceptual model is presented, whereby the low water quality is the outcome of three conditions that are met simultaneously: (1) Presence of an organic-rich unit with low permeability that overlies and confines the aquifer; the confining unit contains perched horizons with relatively saline water. (2) Local phreatic/roofed conditions within the aquifer that enable seepage of the organic-rich brackish water from above...
October 11, 2016: Ground Water
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