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https://www.readbyqxmd.com/read/29677538/improvement-effects-of-a-mixed-extract-of-flowers-of-pueraria-thomsonii-benth-and-peels-of-citrus-unshiu-markovich-on-postmenopausal-symptoms-of-ovariectomized-mice
#1
Na-Ra Han, Sun-Young Nam, Sungwei Hong, Hee-Yun Kim, Phil-Dong Moon, Hyeong-Jin Kim, Hosong Cho, Boyoung Lee, Hyung-Min Kim, Hyun-Ja Jeong
BACKGROUND: Menopausal hot flushes occur frequently in postmenopausal women. In the present study, we investigated a regulatory effect of a mixed extract of flowers of Pueraria thomsonii Benth. and peels of Citrus unshiu Markovich (PCE17), an extract of flowers of Pueraria thomsonii Benth. (PE), an extract of peels of Citrus unshiu Markovich (CE), a mixture of tectorigenin 7-O-xylosylglucoside, tectoridin, and tectorigenin (Tec, the active compounds of PE), and hesperidin (Hes, an active compound of CE) on menopausal hot flushes...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29602721/efficacy-and-safety-of-tadalafil-5-mg-once-daily-for-the-treatment-of-erectile-dysfunction-after-robot-assisted-laparoscopic-radical-prostatectomy-a-2-year-follow-up
#2
Soodong Kim, Gyung Tak Sung
BACKGROUND: Although nerve-sparing robot-assisted radical prostatectomy (NS-RALP) is performed, a large number of patients still experience erectile dysfunction (ED) after surgery. AIM: To evaluate the efficacy and safety of tadalafil 5 mg once daily (OaD) in ED treatment over 2 years and investigate the cause of vascular ED after NS-RARP. METHODS: We retrospectively evaluated 95 men who underwent NS-RARP and had a penile rehabilitation treatment with tadalafil 5 mg OaD...
March 27, 2018: Sexual Medicine
https://www.readbyqxmd.com/read/29549104/short-term-effects-of-transdermal-estradiol-in-men-undergoing-androgen-deprivation-therapy-for-prostate-cancer-a-randomized-placebo-controlled-trial
#3
Nicholas Russell, Rudolf Hoermann, Ada S Cheung, Michael Ching, Jd Zajac, David J Handelsman, Mathis Grossmann
OBJECTIVE: There is increasing recognition that, in men, some biological actions attributed to testosterone (T) are mediated by estradiol (E2). This study used two low doses of daily transdermal E2 gel to assess effects on circulating E2 concentrations in men with prostate cancer with suppressed endogenous E2 production arising from androgen deprivation therapy (ADT). Secondarily, we aimed to assess short term biological effects of E2 addback without increasing circulating T. DESIGN: 28-day randomised, placebo-controlled trial Methods: 37 participants were randomised to either 0...
March 16, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29545706/effect-of-aerobic-exercises-versus-laser-acupuncture-in-treatment-of-postmenopausal-hot-flushes-a-randomized-controlled-trial
#4
Eman Abdelfatah Mohamed Elhosary, Mahmoud Mohamed Ewidea, Hamada Ahmed Hamada Ahmed, Ayman El Khatib
[Purpose] To compare the effect of aerobic exercises versus laser acupuncture in treatment of postmenopausal hot flushes. [Subjects and Methods] This study was designed as single blind randomized controlled trial. A total of 48 postmenopausal women complained of hot flushes. Their ages ranged between 45 to 55 years and were randomly assigned into 2 equal groups: group (A), which received an aerobic exercises, and group (B), which received laser acupuncture. Both groups recieved 3 sessions per week for two months...
February 2018: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29542222/mindfulness-cognitive-behavioural-and-behaviour-based-therapy-for-natural-and-treatment-induced-menopausal-symptoms-a-systematic-review-and-meta-analysis
#5
REVIEW
Cmg van Driel, A S Stuursma, M J Schroevers, Mje Mourits, G H de Bock
BACKGROUND: During menopause women experience vasomotor and psychosexual symptoms that cannot entirely be alleviated with hormone replacement therapy (HRT). Besides, HRT is contraindicated after breast cancer. OBJECTIVES: To review the evidence on the effectiveness of psychological interventions in reducing symptoms associated with menopause in natural or treatment-induced menopausal women. SEARCH STRATEGY: Medline/Pubmed, PsycINFO, EMBASE and AMED were searched until June 2017...
March 15, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29533367/tissue-selective-estrogen-complex-tsec-a-review
#6
James H Pickar, Matthieu Boucher, Diana Morgenstern
OBJECTIVE: This review describes historical development of selective estrogen receptor modulators (SERMs) and their combination with estrogens, termed a tissue selective estrogen complex (TSEC), and considers the potential for future TSEC development. METHODS: This narrative review is based on literature identified on PubMed and the TSEC research and development experience of the authors. RESULTS: SERMs have estrogenic and antiestrogenic effects in various tissues; however, no single agent has achieved an optimal balance of agonist and antagonist effects for the treatment of menopausal symptoms...
March 12, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29504865/novel-effect-of-%C3%AE-lactalbumin-on-the-yohimbine-induced-hot-flush-increase-of-the-tail-skin-temperature-in-ovariectomized-rats
#7
Masayuki Uchida, Orie Kobayashi
5-Hydroxytryptamine (5-HT) and noradrenaline have been thought to play important roles in the mechanism of hot flush. Then, to clarify the relation between serotonergic and adrenergic nervous systems on the mechanism of hot flush, the effect of paroxetine, 5-HT reuptake inhibitor (SSRI) was evaluated on the yohimbine-induced hot flush increase of tail skin temperature in ovariectomized female rats. Yohimbine (adrenaline α2 antagonist) significantly increased the tail skin temperature in course of time. Clonidine (adrenaline α2 agonist) significantly attenuated this effect...
March 5, 2018: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29463637/a-diagnostic-red-herring
#8
Alexander J Martin-Bates, Charles Martin-Bates, Richard Withnall
CLINICAL INTRODUCTION: A 29-year-old keen parachutist presented to the emergency services in Cyprus complaining of sudden-onset facial flushing, dizziness and a widespread rash. The episode began on a hot day, 1 hour after she had eaten a breakfast of tinned tuna, and while she was ascending in an aircraft to parachute from 10 000 ft. She completed her jump uneventfully. She had no significant medical history (figure 1).emermed;35/3/184/F1F1F1Figure 1Patient's legs on presentation; this rash was generalised...
March 2018: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29420395/ulipristal-acetate-for-treatment-of-symptomatic-uterine-leiomyomas-a-randomized-controlled-trial
#9
James A Simon, William Catherino, James H Segars, Rick E Blakesley, Anna Chan, Vilma Sniukiene, Ayman Al-Hendy
OBJECTIVE: To assess efficacy and tolerability of ulipristal acetate, a selective progesterone receptor modulator, for treatment of symptomatic uterine leiomyomas. METHODS: This phase 3, double-blind, placebo-controlled study enrolled premenopausal women (aged 18-50 years) with abnormal uterine bleeding, one or more discrete leiomyomas, and uterine size 20 weeks of gestation or less. Patients were randomized 1:1:1 to 5 mg ulipristal, 10 mg ulipristal, or placebo once daily for 12 weeks followed by 12-week drug-free follow-up...
March 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29415060/precision-of-mri-based-body-composition-measurements-of-postmenopausal-women
#10
Janne West, Thobias Romu, Sofia Thorell, Hanna Lindblom, Emilia Berin, Anna-Clara Spetz Holm, Lotta Lindh Åstrand, Anette Karlsson, Magnus Borga, Mats Hammar, Olof Dahlqvist Leinhard
OBJECTIVES: To determine precision of magnetic resonance imaging (MRI) based fat and muscle quantification in a group of postmenopausal women. Furthermore, to extend the method to individual muscles relevant to upper-body exercise. MATERIALS AND METHODS: This was a sub-study to a randomized control trial investigating effects of resistance training to decrease hot flushes in postmenopausal women. Thirty-six women were included, mean age 56 ± 6 years. Each subject was scanned twice with a 3...
2018: PloS One
https://www.readbyqxmd.com/read/29403626/a-review-of-effective-herbal-medicines-in-controlling-menopausal-symptoms
#11
REVIEW
Rahele Kargozar, Hoda Azizi, Roshanak Salari
Background: Acute menopausal syndrome especially hot flashes, is one of the most common gynecological problems during menopause. Due to the side effects of hormone therapy, herbal and complementary medicines are always of immense interest to people in the treatment and management of the symptoms and complications of menopause. Objective: The aim of this study was to investigate the mechanisms and effects of medicinal plants employed in the treatment of menopausal symptoms...
November 2017: Electronic Physician
https://www.readbyqxmd.com/read/29390899/vasomotor-symptoms-natural-history-physiology-and-links-with-cardiovascular-health
#12
R C Thurston
Vasomotor symptoms (VMS), or hot flushes and night sweats, are the classic symptom of menopause. Recent years have brought key advances in the knowledge about VMS. VMS last longer than previously thought, on average 7-10 years for frequent or moderate to severe VMS. Although VMS have long been understood to be important to women's quality of life, research has also linked VMS to indicators of cardiovascular disease (CVD) risk, such as an adverse CVD risk factor profile, greater subclinical CVD and, in emerging work, CVD events...
April 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29390893/association-of-body-composition-with-menopausal-symptoms-in-peri-menopausal-women
#13
Y Zhou, Y Zheng, C Li, J Hu, Y Zhou, L Geng, M Tao
OBJECTIVE: To explore the correlation of body composition with the severity of menopausal symptoms, as well as each classic menopausal symptom. METHODS: A total of 758 (peri-)menopausal women were recruited (aged from 40 to 67 years) from the Menopause Clinic in the Shanghai Sixth People's Hospital. Different regions of fat mass, lean mass and fat-free mass were measured by bioelectrical impedance analysis, while menopausal symptoms were evaluated by valid modified Kupperman's index (KMI) in the Chinese version...
April 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29372157/clinical-experience-of-long-term-use-of-dienogest-after-surgery-for-ovarian-endometrioma
#14
Anjali Chandra, A Mi Rho, Kyungah Jeong, Taeri Yu, Ji Hyun Jeon, So Yun Park, Sa Ra Lee, Hye-Sung Moon, Hye Won Chung
Objective: Endometriosis is a common and recurring gynecologic disease which have afflicting females of reproductive age. We investigated the efficacy of long-term, post-operative use of dienogest for ovarian endometrioma. Methods: We studied 203 patients who had undergone laparoscopic or robotic surgery for ovarian endometrioma, and were administrated dienogest 2 mg/day beginning in July of 2013, and continuing. We evaluated side effects of dienogest and ultrasonography was performed every 6 months to detect potential recurrence of endometrioma (2 cm) in these post-surgical patients...
January 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29315132/self-help-cognitive-behavior-therapy-for-working-women-with-problematic-hot-flushes-and-night-sweats-menos-work-a-multicenter-randomized-controlled-trial
#15
Claire Hardy, Amanda Griffiths, Sam Norton, Myra S Hunter
OBJECTIVE: The aim of the study was to examine the efficacy of an unguided, self-help cognitive behavior therapy (SH-CBT) booklet on hot flush and night sweat (HFNS) problem rating, delivered in a work setting. METHODS: Women aged 45 to 60 years, having 10 or more problematic HFNS a week, were recruited to a multicenter randomized controlled trial, via the occupational health/human resources departments of eight organizations. Participants were 1:1 randomized to SH-CBT or no treatment waitlist control (NTWC)...
January 8, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29290928/treating-hot-flushes-with-a-neurokinin-3-receptor-antagonist
#16
EDITORIAL
Julia K Prague, Waljit S Dhillo
No abstract text is available yet for this article.
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29216870/prevalence-and-severity-of-menopause-symptoms-among-perimenopausal-and-postmenopausal-women-aged-30-49-years-in-gulele-sub-city-of-addis-ababa-ethiopia
#17
Engida Yisma, Natnael Eshetu, Stephanie Ly, Berhanu Dessalegn
BACKGROUND: Menopause is a natural phenomenon occurring as women approach middle-age. It is characterized by declining of ovarian function and onset of the last menstrual period and subsequent 12-month cessation of menstruation. Due to a growing aging population and longer life expectancies, sub-Saharan African women will spend a significant portion of their lives in postmenopause. Menopausal symptom research has been primarily conducted on Caucasian women from high-income countries. Understanding menopause symptom prevalence and perceptions among diverse women in Ethiopia will better inform reproductive health care...
December 8, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/29216361/gonadotropin-releasing-hormone-receptor-antagonist-mono-and-combination-therapy-with-estradiol-norethindrone-acetate-add-back-pharmacodynamics-and-safety-of-obe2109
#18
Oliver Pohl, Line Marchand, Neil Fawkes, Jean-Pierre Gotteland, Ernest Loumaye
Context: OBE2109 is a potent, oral gonadotropin-releasing hormone receptor antagonist being developed for the treatment of sex-hormone-dependent diseases in women. Objective: We assessed the pharmacodynamics and safety of OBE2109 alone and combined with estradiol (E2)/norethindrone acetate (NETA) add-back therapy on E2 levels and vaginal bleeding. Design, Setting, and Participants: This was a single-center, open-label, randomized, parallel-group study in 76 healthy premenopausal women...
February 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29187690/-treatment-for-paroxysmal-sympathetic-hyperactivity-in-amyotrophic-lateral-sclerosis-patient
#19
Katsunori Yokoi, Tetsuo Ando, Sawao Ishikawa
We report a case of an 80-year-old man who contracted amyotrophic lateral sclerosis (ALS) 15 years ago, was put on a ventilator 8 years ago, and became locked in 3 years ago. Two years ago, he began to suffer from sudden symptoms of paroxysmal sympathetic hyperactivity (PSH) attacks (hot flushes, abnormal sweating, tachycardia, and increased blood pressure). One day, he developed multiple-organ failure. This failure healed in a few days, but PSH attacks remained. His catecholamine levels were abnormal: adrenaline, 215 pg/ml; noradrenaline, 5,960 pg/ml; and dopamine, 606 pg/ml...
December 27, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/29166793/the-use-and-discontinuation-of-hormone-replacement-therapy-in-women-in-south-china
#20
K Chu, Y Song, N D Chatooah, Q Weng, Q Ying, L Ma, F Qu, J Zhou
OBJECTIVE: The use of hormone replacement therapy (HRT) started later in China than in European countries. The purpose of the present study was to investigate HRT patterns and reasons for the initiation and discontinuation of HRT among women in South China. METHODS: A telephone survey about menopausal status, the use of HRT, reasons for HRT discontinuation and duration of HRT treatment was conducted in 2014. RESULTS: A total of 825 telephone surveys were carried out, and 217 previous HRT users and 390 current users were recruited for this study...
February 2018: Climacteric: the Journal of the International Menopause Society
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