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https://www.readbyqxmd.com/read/29216870/prevalence-and-severity-of-menopause-symptoms-among-perimenopausal-and-postmenopausal-women-aged-30-49%C3%A2-years-in-gulele-sub-city-of-addis-ababa-ethiopia
#1
Engida Yisma, Natnael Eshetu, Stephanie Ly, Berhanu Dessalegn
BACKGROUND: Menopause is a natural phenomenon occurring as women approach middle-age. It is characterized by declining of ovarian function and onset of the last menstrual period and subsequent 12-month cessation of menstruation. Due to a growing aging population and longer life expectancies, sub-Saharan African women will spend a significant portion of their lives in postmenopause. Menopausal symptom research has been primarily conducted on Caucasian women from high-income countries. Understanding menopause symptom prevalence and perceptions among diverse women in Ethiopia will better inform reproductive health care...
December 8, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/29216361/gnrh-receptor-antagonist-mono-and-combination-therapy-with-e2-neta-add-back-pharmacodynamics-and-safety-of-obe2109
#2
Oliver Pohl, Line Marchand, Neil Fawkes, Jean-Pierre Gotteland, Ernest Loumaye
Context: OBE2109 is a novel, potent, oral gonadotropin-releasing hormone receptor antagonist being developed for the treatment of sex-hormone-dependent diseases in women. Objective: We assessed the pharmacodynamics and safety of OBE2109 alone and combined with estradiol(E2)/norethindrone acetate(NETA) add-back therapy on E2 levels and vaginal bleeding. Design, Setting, and Participants: This was a single-center, open-label, randomized, parallel-group study in 76 healthy premenopausal women with regular menstrual cycles...
December 4, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29187690/-treatment-for-paroxysmal-sympathetic-hyperactivity-in-amyotrophic-lateral-sclerosis-patient
#3
Katsunori Yokoi, Tetsuo Ando, Sawao Ishikawa
We report a case of an 80-year-old man who contracted amyotrophic lateral sclerosis (ALS) 15 years ago, was put on a ventilator 8 years ago, and became locked in 3 years ago. Two years ago, he began to suffer from sudden symptoms of paroxysmal sympathetic hyperactivity (PSH) attacks (hot flushes, abnormal sweating, tachycardia, and increased blood pressure). One day, he developed multiple-organ failure. This failure healed in a few days, but PSH attacks remained. His catecholamine levels were abnormal: adrenaline, 215 pg/ml; noradrenaline, 5,960 pg/ml; and dopamine, 606 pg/ml...
November 28, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/29166793/the-use-and-discontinuation-of-hormone-replacement-therapy-in-women-in-south-china
#4
K Chu, Y Song, N D Chatooah, Q Weng, Q Ying, L Ma, F Qu, J Zhou
OBJECTIVE: The use of hormone replacement therapy (HRT) started later in China than in European countries. The purpose of the present study was to investigate HRT patterns and reasons for the initiation and discontinuation of HRT among women in South China. METHODS: A telephone survey about menopausal status, the use of HRT, reasons for HRT discontinuation and duration of HRT treatment was conducted in 2014. RESULTS: A total of 825 telephone surveys were carried out, and 217 previous HRT users and 390 current users were recruited for this study...
November 23, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29161918/in-process-rheometry-as-a-pat-tool-for-hot-melt-extrusion
#5
A L Kelly, T Gough, M Isreb, R Dhumal, J W Jones, S Nicholson, A B Dennis, A Paradkar
Real time measurement of melt rheology has been investigated as a Process Analytical Technology (PAT) to monitor hot melt extrusion of an Active Pharmaceutical Ingredient (API) in a polymer matrix. A developmental API was melt mixed with a commercial copolymer using a heated twin screw extruder at different API loadings and set temperatures. The extruder was equipped with an instrumented rheological slit die which incorporated three pressure transducers flush mounted to the die surface. Pressure drop measurements within the die at a range of extrusion throughputs were used to calculate rheological parameters such as shear viscosity and exit pressure, related to shear and elastic melt flow properties respectively...
November 22, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29158902/hypernatraemic-hypovolaemia-with-anaemia-an-unusual-presentation-of-primary-testicular-insufficiency
#6
Usman Javaid, Vikram Lal, Catherine Napier, Alison Burbridge, Richard Quinton
Hypogonadal men may experience intense vasomotor symptoms, and vasomotor sweating can occasionally be associated with profound fluid losses. We describe a 37-year-old male, who exhibited persistent hypovolaemic hypernatraemia that was challenging to treat despite a continuous high fluid input (>4-5 L/day). He was noted to have drenching sweats and normochromic anaemia. He had recent traumatic head injury, which resulted in neurocognitive dysfunction, so pituitary function tests were done which showed primary hypogonadism...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29157487/contr%C3%A3-le-de-l%C3%A2-axe-gonadotrope-nouveaux-aspects-physiologiques-et-th%C3%A3-rapeutiques-control-of-the-gonadotrope-axis-new-physiologic-and-therapeutic-aspects
#7
L Maione, S Christin-Maître, P Chanson, J Young
The endocrine and exocrine functions of the gonads are controlled by the gonadotrope axis, whose master regulator is the hypothalamic decapeptide GnRH. The Kisspeptin/Neurokinin B (Kp/NkB) neuronendocrine system is the main physiologic regulator of GnRH neurons. The Kp/NkB system is currently considered the key mediator for the hypothalamic negative feedback exerted by sex steroids and prolactin, as well as by various metabolic signals. Intrinsic alterations or regulatory abnormalities of Kp/NkB system lead to various gonadotrope axis puberty and fertility dysfunctions...
October 2017: Annales D'endocrinologie
https://www.readbyqxmd.com/read/29139105/preoperative-medical-therapy-before-surgery-for-uterine-fibroids
#8
REVIEW
Anne Lethaby, Lucian Puscasiu, Beverley Vollenhoven
BACKGROUND: Uterine fibroids occur in up to 40% of women aged over 35 years. Some are asymptomatic, but up to 50% cause symptoms that warrant therapy. Symptoms include anaemia caused by heavy menstrual bleeding, pelvic pain, dysmenorrhoea, infertility and low quality of life. Surgery is the first choice of treatment. In recent years, medical therapies have been used before surgery to improve intraoperative and postoperative outcomes. However, such therapies tend to be expensive.Fibroid growth is stimulated by oestrogen...
November 15, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29105043/quality-of-life-among-postmenopausal-women-in-rural-minia-egypt
#9
Nashwa N Kamal, Amany E Seedhom
This study aimed to determine the prevalence and severity of menopausal symptoms and their effect on the quality of life of postmenopausal women in rural Minia. A cross-sectional study was conducted among 1 100 postmenopausal women aged 45-60 years selected by multistage random sampling. The menopause rating scale (MRS) was used to assess the menopausal symptoms. The mean age at menopause was 48.9 (SD 4) years. The most frequent symptoms were joint and muscle pain (82.1%), physical and mental exhaustion (69...
October 30, 2017: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/29084357/adverse-events-associated-with-medium-and-long-term-use-of-opioids-for-chronic-non-cancer-pain-an-overview-of-cochrane-reviews
#10
REVIEW
Charl Els, Tanya D Jackson, Diane Kunyk, Vernon G Lappi, Barend Sonnenberg, Reidar Hagtvedt, Sangita Sharma, Fariba Kolahdooz, Sebastian Straube
BACKGROUND: Chronic pain is common and can be challenging to manage. Despite increased utilisation of opioids, the safety and efficacy of long-term use of these compounds for chronic non-cancer pain (CNCP) remains controversial. This overview of Cochrane Reviews complements the overview entitled 'High-dose opioids for chronic non-cancer pain: an overview of Cochrane Reviews'. OBJECTIVES: To provide an overview of the occurrence and nature of adverse events associated with any opioid agent (any dose, frequency, or route of administration) used on a medium- or long-term basis for the treatment of CNCP in adults...
October 30, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29064335/overall-safety-of-ospemifene-in-postmenopausal-women-from-placebo-controlled-phase-2-and-3-trials
#11
James A Simon, Corrado Altomare, Susannah Cort, Wei Jiang, JoAnn V Pinkerton
OBJECTIVE: To evaluate the safety of daily oral ospemifene 60 mg, estrogen agonist/antagonist, used to treat moderate-to-severe dyspareunia due to postmenopausal vulvovaginal atrophy, which is part of genitourinary syndrome of menopause. METHODS: Post hoc analysis of safety data (treatment-emergent adverse events [TEAEs]) pooled from six phase 2 and 3 randomized, double-blind, multicenter placebo-controlled studies, evaluating the effects of ospemifene 60 mg on the breast, cardiovascular system, and bone in postmenopausal women...
October 24, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/29040006/neurokinin-3-receptor-antagonism-the-magic-bullet-for-hot-flushes
#12
J K Prague, W S Dhillo
Hot flushes affect 70% of menopausal women and are reported as being the most bothersome symptom by the majority. Hormone replacement therapy and other currently available alternative therapies are not without side-effects and/or have variable efficacy, and so an effective novel therapy could be practice-changing. Over the last 20 years, numerous studies in animal and human models have implicated neurokinin B, a hypothalamic neuropeptide, together with its receptor (NK3R) in the etiology of menopausal hot flushes...
October 17, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28982960/management-of-endocrine-disease-flushing-current-concepts
#13
REVIEW
Isabel Huguet, Ashley Grossman
OBJECTIVE: Flushing can be defined as a sensation of warmth accompanied by erythema that most commonly is seen on the face and which occurs in episodic attacks. Such a problem can be clinically problematic, since many conditions and drugs can be related to flushing, and while often there appears to be no underlying organic disease, it is important to exclude disorders since they may be life-threatening conditions. DESIGN AND METHODS: We performed a search in MEDLINE using the terms 'flushing' in combination with 'carcinoid syndrome', 'pheochromocytoma', 'mastocytosis', 'menopausal hot flush' and 'treatment'...
November 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28969260/tamoxifen-induced-pancreatitis-an-unusual-complication-of-commonly-used-drug
#14
Pritam Suresh Chandra Kataria, Pradip Piraji Kendre, Apurva Ashok Patel, Murtaza Zoher Bohra, Nahush Tahiliani
Tamoxifen is a selective oestrogen receptor modulator used for the treatment of oestrogen/progesterone receptor positive breast cancer. It possess antagonistic or agonistic activity depending on the tissue location i.e., antagonistic action on breast but agonist action on endometrium and bones. The side effects of tamoxifen include hot flushes, gynaecologic symptoms (vaginal dryness, vaginal discharge), depression, forgetfulness, sleep alterations, weight gain, alteration of lipoprotein metabolism, thromboembolic disorder...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28938674/network-meta-analysis-of-the-efficacy-and-adverse-effects-of-several-treatments-for-advanced-metastatic-prostate-cancer
#15
Jing Wu, Wei-Kang Chen, Wei Zhang, Jin-Song Zhang, Jian-He Liu, Yong-Ming Jiang, Ke-Wei Fang
This network meta-analysis was conducted to compare the efficacy and adverse effects of several treatments for advanced/metastatic prostate cancer (PC). The PubMed and Cochrane Library databases were searched for randomized controlled trials of treatments for advanced/metastatic PC. Eighteen studies covering 6,340 patients were included in this analysis. The calculated were odds ratios, 95% confidence intervals, and the surface under the cumulative ranking (SUCRA) curve. Pairwise meta-analysis showed that overall survival rates achieved with radiotherapy or endocrine therapy were lower than obtained with radiotherapy + endocrine therapy...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28933968/influence-of-menopausal-symptoms-on-perceived-work-ability-among-women-in-a-nigerian-university
#16
A O Olajubu, A E Olowokere, D O Amujo, T O Olajubu
OBJECTIVES: This study investigated the menopausal symptoms experienced by women of menopausal age in Ekiti State, Nigeria and the influence on their perceived work ability. METHOD: A descriptive cross-sectional research design was employed and the study was conducted among 200 working-class women aged 45 years and above who had experienced at least 12 continuous months of amenorrhea in Ekiti State University, Ado Ekiti. A semi-structured questionnaire adapted from the Greene Climacteric Scale and the work ability index was used to assess menopausal symptoms and work ability, respectively...
September 21, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28904704/-prolactin-secreting-microadenoma-in-menopausal-women
#17
Ines Barka, Emna Dendana, Nesrine Chikhrouhou, Amel Maroufi, Maha Kacem, Molka Chadli, Koussay Ach
Prolactin-secreting adenoma is rare in elderly women. Patient's clinical picture may be confused with that of menopause, making diagnosis sometimes difficult. We report the case of a 57-year old woman with a 2-year history of secondary amenorrhea without hot flushes associated with galactorrhea in order to highlight the peculiarities of prolactin-secreting microadenomas. Physical examination confirmed the diagnosis of galactorrhoea and biology showed hyperprolactinemia at mIU/L, FSH = 15.1 IU/L and LH = 4,1 IU/L...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28903474/nitric-oxide-heat-shock-protein-axis-in-menopausal-hot-flushes-neglected-metabolic-issues-of-chronic-inflammatory-diseases-associated-with-deranged-heat-shock-response
#18
Antônio Azambuja Miragem, Paulo Ivo Homem de Bittencourt
BACKGROUND: Although some unequivocal underlying mechanisms of menopausal hot flushes have been demonstrated in animal models, the paucity of similar approaches in humans impedes further mechanistic outcomes. Human studies might show some as yet unexpected physiological mechanisms of metabolic adaptation that permeate the phase of decreased oestrogen levels in both symptomatic and asymptomatic women. This is particularly relevant because both the severity and time span of hot flushes are associated with increased risk of chronic inflammatory disease...
September 1, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28899509/a-standardized-humulus-lupulus-l-ethanol-extract-partially-prevents-ovariectomy-induced-bone-loss-in-the-rat-without-induction-of-adverse-effects-in-the-uterus
#19
Annekathrin M Keiler, Janina Helle, Manuela I Bader, Tino Ehrhardt, Kristin Nestler, Georg Kretzschmar, Ricardo Bernhardt, Günter Vollmer, Dejan Nikolić, Judy L Bolton, Guido F Pauli, Shao-Nong Chen, Birgit M Dietz, Richard B van Breemen, Oliver Zierau
BACKGROUND: Hops (Humulus lupulus (L.)) dietary supplements are of interest as herbal remedies to alleviate menopausal symptoms, such as hot flushes, depression and anxiety. So far, the evidence regarding estrogenic and related properties of hops preparations has been considered insufficient for a market authorization for menopausal indications. PURPOSE: The study aims to investigate a chemically standardized hops extract regarding its safety in the uterus, as wells as its efficacy to prevent bone loss in the ovariectomized rat model...
October 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28890285/rate-of-legionella-pneumophila-colonization-in-hospital-hot-water-network-after-time-flow-taps-installation
#20
M Totaro, P Valentini, A L Costa, S Giorgi, B Casini, A Baggiani
In hospital water systems legionellae may be resistant to disinfectants in pipework, which is a problem particularly in areas where there is low flow or stagnation of water. We evaluated legionella colonization of a water network of an Italian hospital after time flow taps (TFTs) installation in proximity to dead legs. The water volume flushed was 64 L/day from May 2016, and 192 L/day from December 2016. Before TFTs installation, Legionella pneumophila sg2-14 was detected in all points (4 × 10(4) ± 3...
September 7, 2017: Journal of Hospital Infection
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