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https://www.readbyqxmd.com/read/29673743/the-50-10-oxygen-induced-retinopathy-model-serves-as-a-hyperoxia-and-hypoxia-model-of-bronchopulmonary-dysplasia
#1
Huijuan Li, Ruyuan Zhu, Lijuan Qian, Wen Jin, Jiali Xie, Shumin Kang, Lijun Lu, Mingyu Tao, Li Jiang
BACKGROUND: Animal models of bronchopulmonary dysplasia (BPD) are mainly created by hyperoxia exposure. However, these models do not fully recapitulate BPD pathophysiology as observed in clinical practice. To find a better BPD model, we established a rat 50/10 oxygen-induced retinopathy (OIR) model and analyzed the pathologic features of the lungs. METHODS: The rat OIR model was established by exposing newborn rats (P0) to 50% and 10% oxygen (hyperoxia and hypoxia) on alternating days for 14 days...
February 2, 2018: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/29669344/unique-heterogeneous-topological-pattern-of-the-metabolic-landscape-in-rabbit-fetal-lungs-following-tracheal-occlusion
#2
Ahmed I Marwan, Uladzimir Shabeka, Julie A Reisz, Connie Zheng, Natalie J Serkova, Evgenia Dobrinskikh
INTRODUCTION: Fetal tracheal occlusion (TO) is currently an experimental approach to drive accelerated lung growth. It is stimulated by mechanotransduction that results in increased cellular proliferation and growth. However, it is currently unknown how TO affects the metabolic landscape of fetal lungs. MATERIALS AND METHODS: TO or sham was performed on fetal rabbits at 26 days followed by lung harvest on day 30. Mass spectrometry was performed to evaluate global metabolic changes...
April 18, 2018: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29661611/nasal-polyposis-or-chronic-olfactory-rhinitis
#3
R Jankowski, C Rumeau, P Gallet, D T Nguyen
The concept of chronic rhinosinusitis with or without polyps is founded on the structural and functional unicity of the pituitary mucosa and its united response to environmental aggression by allergens, viruses, bacteria, pollution, etc. The present review sets this concept against the evo-devo three-nose theory, in which nasal polyposis is distinguished as specific to the olfactory nose and in particular to the non-olfactory mucosa of the ethmoid, which is considered to be not a sinus but rather the skull-base bone harboring the olfactory mucosa...
April 13, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29660682/insights-into-the-binding-behavior-of-bovine-serum-albumin-to-black-carbon-nanoparticles-and-induced-cytotoxicity
#4
Hai Wu, Miaomiao Chen, Mengting Shang, Xiang Li, Kui Mu, Suhua Fan, Shuanglin Jiang, Wenyong Li
Black carbon (BC) is a main component of particulate matter (PM2.5 ). Due to their small size (<100nm), inhaled ultrafine BC nanoparticles may penetrate the lung alveoli, where they interact with surfactant proteins and lipids, causing more serious damage to human health. Here, BC was analyzed to investigate the binding mechanism of its interaction with protein and induction of cytotoxicity changes. The binding process and protein conformation between BC and a serum protein (bovine serum albumin, BSA) were monitored by using a fluorescence quenching technique and UV-vis absorption, Fourier transform infrared (FTIR) and circular dichroism (CD) spectroscopies...
April 6, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29652806/excessive-extracellular-atp-desensitizes-p2y2-and-p2x4-atp-receptors-provoking-surfactant-impairment-ending-in-ventilation-induced-lung-injury
#5
REVIEW
Djo Hasan, Joshua Satalin, Philip van der Zee, Michaela Kollisch-Singule, Paul Blankman, Atsuko Shono, Peter Somhorst, Corstiaan den Uil, Han Meeder, Toru Kotani, Gary F Nieman
Stretching the alveolar epithelial type I (AT I) cells controls the intercellular signaling for the exocytosis of surfactant by the AT II cells through the extracellular release of adenosine triphosphate (ATP) (purinergic signaling). Extracellular ATP is cleared by extracellular ATPases, maintaining its homeostasis and enabling the lung to adapt the exocytosis of surfactant to the demand. Vigorous deformation of the AT I cells by high mechanical power ventilation causes a massive release of extracellular ATP beyond the clearance capacity of the extracellular ATPases...
April 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29652756/radiological-evaluation-of-the-dimensions-of-lower-molar-alveoli
#6
Claudio Agostinelli, Agnese Agostinelli, Marco Berardini, Paolo Trisi
PURPOSE: The aim of the present radiological study was to analyze the alveolar bone morphology of the lower molars in physiological conditions. The main goal is to describe the bone anatomy of a hypothetically postextractive site in lower molar area. MATERIALS AND METHODS: Computed tomography scans of 100 patients were examined. Axial, paraxial, and Panorex sections were analyzed using a dedicated software. Precise reference points were encoded to make the bone measurements clear and repeatable...
April 12, 2018: Implant Dentistry
https://www.readbyqxmd.com/read/29652291/whole-lung-lavage-in-a-patient-with-pulmonary-alveolar-proteinosis
#7
Lindsay R Hunter Guevara, Shane M Gillespie, Alan M Klompas, Norman E Torres, David W Barbara
Pulmonary alveolar proteinosis (PAP) is a rare syndrome in which phospholipoproteinaceous matter accumulates in the alveoli leading to compromised gas exchange. Whole-lung lavage is considered the gold standard for severe autoimmune PAP and offers favorable long-term outcomes. In this case report, we describe the perioperative management and procedural specifics of a patient undergoing WLL for PAP in which an anesthesiologist serves as the proceduralist and a separate anesthesiologist provides anesthesia care for the patient...
April 2018: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/29650311/an-object-oriented-computational-model-to-study-cardiopulmonary-hemodynamic-interactions-in-humans
#8
Chuong Ngo, Stephan Dahlmanns, Thomas Vollmer, Berno Misgeld, Steffen Leonhardt
BACKGROUND AND OBJECTIVE: This work introduces an object-oriented computational model to study cardiopulmonary interactions in humans. METHODS: Modeling was performed in object-oriented programing language Matlab Simscape, where model components are connected with each other through physical connections. Constitutive and phenomenological equations of model elements are implemented based on their non-linear pressure-volume or pressure-flow relationship. The model includes more than 30 physiological compartments, which belong either to the cardiovascular or respiratory system...
June 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29630123/il-33-induced-inflammation-exacerbated-the-development-of-chronic-obstructive-pulmonary-disease-through-oxidative-stress
#9
S-C Zou, J Jiang, J Song
OBJECTIVE: We aimed at exploring the role of IL-33 in mouse chronic obstructive pulmonary disease and its potential molecular mechanism. MATERIALS AND METHODS: The chronic obstructive pulmonary disease (COPD) mice model was established by cigarette smoking (CS). COPD mice were randomly assigned into PBS group and IL-33 antibody group. The peripheral blood and lung tissues of mice from two groups were collected for the following experiments. Pathological changes of the lung tissues in both groups were analyzed by hematoxylin and eosin (HE) staining...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29610254/hypervirulent-group-a-streptococcus-of-genotype-emm-3-invades-the-vascular-system-in-pulmonary-infection-of-mice
#10
Benfang Lei, Dylan Minor, Wenchao Feng, Mengyao Liu
Natural mutations of the two-component regulatory system CovRS are frequently associated with invasive Group A Streptococcus (GAS) isolates and lead to the enhancement in virulence gene expression, innate immune evasion, systemic dissemination, and virulence. How CovRS mutations enhance systemic dissemination is not well understood. A hypervirulent GAS isolate of the emm3 genotype, MGAS315, was characterized using a mouse model of pulmonary infection to understand systemic dissemination. This strain has a G1370T mutation in the sensor kinase covS gene of CovRS...
April 2, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29606266/-pulmonary-ultrasound-and-dialysis
#11
Alexandre Seidowsky, Ève Vilaine, Nicolas Mansencal, Alexandre Ébel, Cédric Villain, Lynda Cheddani, Ziad A Massy
Profound deficit of the body fluid composition regulation system is present at the end stage kidney disease, leading to the increase the risk of acute or chronic volume overload, which impacts the morbidity and mortality in these patients. Pulmonary ultrasound by its ability to estimate extrapulmonary water at an infraclinical stage has helped to make progress in this area. Line B is the element of fundamental semiology that reflects the presence of water in the pulmonary alveoli. The alteration of left ventricular function and the increase of pulmonary capillary permeability are the determining factors in the genesis of subclinical pulmonary congestion and are positively correlated with B-lines...
April 2018: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29596290/use-of-recruitment-maneuvers-in-patients-with-acute-respiratory-distress-syndrome
#12
Angela Nguyen
Acute respiratory distress syndrome (ARDS) is a deadly complication in critically ill patients that causes significant morbidity and mortality. Patients with ARDS are seen across intensive care unit settings, with treatment being largely supportive involving techniques through mechanical ventilation. Using low-tidal-volume ventilation is a standard of practice for patients with ARDS, as a lung protection strategy; however, alveolar decruitment may occur. Recruitment maneuvers can recruit collapsed alveoli and promote oxygenation...
May 2018: Dimensions of Critical Care Nursing: DCCN
https://www.readbyqxmd.com/read/29575957/ventilator-induced-lung-injury-during-controlled-ventilation-in-patients-with-acute-respiratory-distress-syndrome-less-is-probably-better
#13
Fernanda Ferreira Cruz, Lorenzo Ball, Patricia Rieken Macedo Rocco, Paolo Pelosi
Mechanical ventilation is required to support respiratory function in the acute respiratory distress syndrome (ARDS), but it may promote lung damage, a phenomenon known as ventilator-induced lung injury (VILI). Areas covered: Several mechanisms of VILI have been described, such as: inspiratory and/or expiratory stress inducing overdistension (volutrauma); interfaces between collapsed or edema-filled alveoli with surrounding open alveoli, acting as stress raisers; alveoli that repetitively open and close during tidal breathing (atelectrauma); and peripheral airway dynamics...
March 26, 2018: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/29574785/resident-alveolar-macrophages-are-master-regulators-of-arrested-alveolarization-in-experimental-bronchopulmonary-dysplasia
#14
Tatiana V Kalymbetova, Balachandar Selvakumar, José Alberto Rodríguez-Castillo, Miša Gunjak, Christina Malainou, Miriam Ruth Heindl, Alena Moiseenko, Cho-Ming Chao, István Vadász, Konstantin Mayer, Jürgen Lohmeyer, Saverio Bellusci, Eva Böttcher-Friebertshäuser, Werner Seeger, Susanne Herold, Rory E Morty
Trophic functions for macrophages are emerging as key mediators of developmental processes; including bone, vessel, and mammary gland development. Yolk sac-derived macrophages mature in the distal lung shortly after birth. Myeloid-lineage macrophages are recruited to the lung and are activated under pathological conditions. These pathological conditions include bronchopulmonary dysplasia (BPD), a common complication of preterm birth characterized by stunted lung development, where formation of alveoli is blocked...
March 25, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29571671/impact-of-particulate-deproteinized-bovine-bone-mineral-and-porous-titanium-granules-on-early-stability-and-osseointegration-of-dental-implants-in-narrow-marginal-circumferential-bone-defects
#15
A Verket, S P Lyngstadaas, H Tiainen, H J Rønold, J C Wohlfahrt
The use of two particulate bone graft substitute materials in experimental narrow marginal peri-implant bone defects was investigated with respect to early bone healing and implant stability. Porous titanium granules, oxidized white porous titanium granules (WPTG), and demineralized bovine bone mineral (DBBM) were characterized in vitro, after which the two latter materials were tested in experimental peri-implant bone defects in six minipigs, with empty defects as control. After mandibular premolar extraction, the top 5mm of the alveoli were widened to 6mm in diameter, followed by the placement of six implants, three on each side, in each pig...
March 20, 2018: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29570757/simulation-of-airflow-in-an-idealized-emphysematous-human-acinus
#16
Amitvikram Dutta, Dragos Vasilescu, James C Hogg, A B Phillion, Joshua R Brinkerhoff
Emphysema is the permanent enlargement of air spaces in the respiratory regions of the lung due to destruction of the inter-alveolar septa. The progressive coalescence of alveoli and alveolar ducts into larger airspaces leads to the disruption of normal airway wall motion and airflow rates within the pulmonary acinus. To contribute to the understanding of the individual effects of emphysema during its earliest stages, computational fluid dynamics simulations of airflow in mathematically-derived models of the pulmonary acinus were performed...
March 21, 2018: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29557796/anatomical-and-radiologic-evaluation-of-the-dimensions-of-upper-molar-alveoli
#17
Claudio Agostinelli, Agnese Agostinelli, Marco Berardini, Paolo Trisi
PURPOSE: The aim of the present study was to analyze the alveolar bone morphology of the upper first and second molars. This analysis aims to evaluate the morphology of a hypothetical postextractive site in the upper molar area to diagnose the possibility of immediate postextraction implant placement. MATERIALS AND METHODS: Cone-beam CT scans of 100 patients were examined. The measurements were made using a dedicated 3D software. Reference points were identified to allow clear and repeatable measurements...
March 19, 2018: Implant Dentistry
https://www.readbyqxmd.com/read/29557581/unilateral-pulmonary-hypoplasia-in-an-adult-patient
#18
Dimitrios Papadopoulos, Panagiotis Misthos, Maria Chorti, Vlasios Skopas, Alexandra Nakou, Napoleon Karagianidis, Achilleas Lioulias, Vasiliki Filaditaki
Pulmonary hypoplasia (PH) is a developmental anomaly of the lung parenchyma, characterized by a decrease in the number and size of airways, alveoli and vessels. We present a case of a 31-year-old patient with a history of chronic productive cough and frequent respiratory infections, who was referred for investigation of abnormal chest x-ray. The combination of chest computed tomography (CT) and bronchoscopy set the diagnosis of left pulmonary hypoplasia and the patient was treated surgically with a left pneumonectomy...
January 29, 2018: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/29553050/molecular-mechanisms-of-ventilator-induced-lung-injury
#19
REVIEW
Lin Chen, Hai-Fa Xia, You Shang, Shang-Long Yao
Objective: Mechanical ventilation (MV) has long been used as a life-sustaining approach for several decades. However, researchers realized that MV not only brings benefits to patients but also cause lung injury if used improperly, which is termed as ventilator-induced lung injury (VILI). This review aimed to discuss the pathogenesis of VILI and the underlying molecular mechanisms. Data Sources: This review was based on articles in the PubMed database up to December 2017 using the following keywords: "ventilator-induced lung injury", "pathogenesis", "mechanism", and "biotrauma"...
March 19, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29550472/pentagalloyl-glucose-increases-elastin-deposition-decreases-reactive-oxygen-species-and-matrix-metalloproteinase-activity-in-pulmonary-fibroblasts-under-inflammatory-conditions
#20
Vaideesh Parasaram, Nasim Nosoudi, Aniqa Chowdhury, Naren Vyavahare
mphysema is characterized by degradation of lung alveoli that leads to poor airflow in lungs. Irreversible elastic fiber degradation by matrix metalloproteinases (MMPs) and reactive oxygen species (ROS) activity leads to loss of elasticity and drives the progression of this disease. We investigated if a polyphenol, pentagalloyl glucose (PGG) can increase elastin production in pulmonary fibroblasts. We also studied the effect of PGG treatment in reducing MMP activity and ROS levels in cells. We exposed rat pulmonary fibroblasts to two different types of inflammatory environments i...
March 14, 2018: Biochemical and Biophysical Research Communications
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