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https://www.readbyqxmd.com/read/28811681/osteopontin-impacts-west-nile-virus-pathogenesis-and-resistance-by-regulating-inflammasome-components-and-cell-death-in-the-central-nervous-system-at-early-time-points
#1
Nikki Bortell, Claudia Flynn, Bruno Conti, Howard S Fox, Maria Cecilia G Marcondes
Osteopontin (OPN) is a molecule that is common in central nervous system (CNS) pathologies, which participates in the activation, migration, and survival of inflammatory cells. However, the mechanisms by which OPN modulates inflammatory pathways are not clear. To understand the role of OPN in CNS viral infections, we used a lethal mouse model of West Nile virus (WNV), characterized by the injection of high doses of the Eg101 strain of WNV, causing the increase of OPN levels in the brain since early time points...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28810044/swept-source-optical-coherence-tomography-angiography-in-west-nile-virus-chorioretinitis-and-associated-occlusive-retinal-vasculitis
#2
Moncef Khairallah, Rim Kahloun, Salma Gargouri, Bechir Jelliti, Dorra Sellami, Salim Ben Yahia, Jamel Feki
A 65-year-old man with diabetes and a history of fever of unknown origin 2 weeks earlier complained of sudden decreased vision in the left eye. The patient was diagnosed with bilateral West Nile virus (WNV) chorioretinitis associated with occlusive retinal vasculitis in the left eye. Swept-source optical coherence tomography angiography (SS-OCTA) of the left eye showed extensive, well-delineated, hypointense non-perfusion areas and perifoveal capillary arcade disruption in the superficial capillary plexus, as well as larger non-perfusion areas, capillary rarefaction, and diffuse capillary network attenuation and disorganization in the deep capillary plexus...
August 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28805636/west-nile-virus-and-its-vectors
#3
REVIEW
Alexander T Ciota
West Nile virus (WNV Flaviviridae; Flavivrus) is the most geographically widespread arbovirus in the world and the leading cause of arboviral encephalitis globally. Worldwide, WNV is maintained in an enzootic cycle between primarily Culex spp. mosquitoes and birds, with human infection and disease resulting from enzootic spillover. Dynamic and complex intrinsic and extrinsic factors contribute to the temporal and spatial variability in WNV transmission. The most current information on the relative contribution of each of these factors is reviewed and a case to incorporate detailed and localized environmental and genetic data into predictive models is presented...
August 2017: Current Opinion in Insect Science
https://www.readbyqxmd.com/read/28803560/evidence-of-exposure-of-laughing-doves-spilopelia-senegalensis-to-west-nile-and-usutu-viruses-in-southern-tunisian-oases
#4
T Ayadi, A Hammouda, A Poux, T Boulinier, S Lecollinet, S Selmi
It has previously been suggested that southern Tunisian oases may be suitable areas for the circulation of flaviviruses. In order to anticipate and prevent possible epidemiological spread of flaviviruses in humans and domestic animals, the ecology of their transmission in the oasis system needs to be better understood. Thus, the aim of this study was to assess the seroprevalence of anti-flavivirus antibodies in the laughing dove (Spilopelia senegalensis), an abundant resident bird in Tunisian oases. Anti-flavivirus antibodies were detected in 17% of sampled doves...
August 14, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28794019/development-of-virus-like-particle-vaccine-and-reporter-assay-for-zika-virus
#5
Himanshu Garg, Melina Sedano, Gabrielle Plata, Erin B Punke, Anjali Joshi
Recent worldwide outbreaks of Zika virus (ZIKV) infection and the lack of an approved vaccine raises serious concerns regarding preparedness to combat this emerging virus. We used a Virus Like Particle (VLP) based approach to develop a vaccine and a microneutralization assay against ZIKV. Synthetic C-prM-E (Capsid-preMembrane-Envelope) gene construct of ZIKV was used to generate Reporter Virus Particles (RVPs) that package GFP reporter expressing WNV replicon. The assay was adapted to 96 well format, similar to the Plaque Reduction Neutralization Test (PRNT) and showed high reproducibility with specific detection of ZIKV neutralizing antibodies...
August 9, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28774315/global-research-trends-in-west-nile-virus-from-1943-to-2016-a-bibliometric-analysis
#6
Samah W Al-Jabi
BACKGROUND: West Nile virus (WNV) is an emerging infectious disease which is most commonly transmitted to humans through mosquito, and is considered a major public-health problem worldwide. The aim of the current study is to bibliometrically analyze the quantity and quality of publications indexed in Scopus from different countries to reveal the characteristics of global research output regarding WNV. METHODS: This study is a bibliometric analysis based on the Scopus database...
August 3, 2017: Globalization and Health
https://www.readbyqxmd.com/read/28758854/3d-qsar-pharmacophore-based-virtual-screening-molecular-docking-and-molecular-dynamics-simulation-toward-identifying-lead-compounds-for-ns2b-ns3-protease-inhibitors
#7
Pei H Luo, Xuan R Zhang, Lan Huang, Lun Yuan, Xang Z Zhou, X Gao, Ling S Li
NS2B-NS3 protease has been identified to serve as lead drug design target due to its significant role in West Nile viral (WNV) and dengue virus (DENV) reproduction and replication. There are currently no approved chemotherapeutic drugs and effective vaccines to inhibit DENV and WNV infections. In this work, 3D-QSAR pharmacophore model has been developed to discover potential inhibitory candidates. Validation through Fischer's model and decoy test indicate that the developed 3D pharmacophore model is highly predictive for DENV inhibitors, which was then employed to screen ZINC chemical library to obtain reasonable hits...
October 2017: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/28756236/accuracy-estimation-of-an-indirect-elisa-for-the-detection-of-west-nile-virus-antibodies-in-wild-birds-using-a-latent-class-model
#8
Marco Tamba, Antonino Caminiti, Alice Prosperi, Philippe Desprès, Davide Lelli, Giorgio Galletti, Ana Moreno, Giulia Paternoster, Annalisa Santi, Elio Licata, Sylvie Lecollinet, Luca Gelmini, Gianluca Rugna, Anna Procopio, Antonio Lavazza
West Nile virus (WNV) and Usutu virus (USUV), genus Flavivirus, are members of the Japanese encephalitis virus antigenic complex, and are maintained primarily in an enzootic cycle between mosquitoes and birds. WNV is zoonotic, and poses a threat to public health, especially in relation to blood transfusion. Serosurveillance of wild birds is suitable for early detection of WNV circulation, although concerns remain to be addressed as regards i) the type of test used, whether ELISA, virus neutralization test (VNT), plaque reduction neutralization test (PRNT), ii) the reagents (antigens, revealing antibodies), iii) the different bird species involved, and iv) potential cross-reactions with other Flaviviruses, such as USUV...
July 27, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28754422/state-of-the-art-vest-nile-virus-circulation-surveillance-in-italy-and-transfusion-risk-early-prevention-methods
#9
C Velati, P Angelini, S Pupella
After the Chikungunya outbreak in 2007 in Italy, a national Plan for the surveillance of human vector-borne diseases has been implemented and annually updated on the basis of the epidemiological changes based-evidences. The transfusion Authorities cooperates, since 2008, with public health services and veterinary (entomological and ornithological) surveillance systems. In some Italian regions, a common protocol for exchanging data is in place to identify the West Nile Virus (WNV) circulation in birds and mosquitoes: the goal is to anticipate the introduction of WNV-NAT screening in blood donors and, on the other hand, to limit testing only in geographic areas where the virus circulation is actual...
July 25, 2017: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/28752627/vector-competence-of-northern-and-southern-european-culex-pipiens-pipiens-mosquitoes-for-west-nile-virus-across-a-gradient-of-temperatures
#10
C B F Vogels, G P Göertz, G P Pijlman, C J M Koenraadt
In Europe, West Nile virus (WNV) outbreaks have been limited to southern and central European countries. However, competent mosquito vectors and susceptible bird hosts are present in northern Europe. Differences in temperature and vector competence of mosquito populations may explain the absence of WNV outbreaks in northern Europe. The aim of the present study was to directly compare vector competence of northern and southern European Culex pipiens (Cx. p.) pipiens mosquitoes for WNV across a gradient of temperatures...
July 28, 2017: Medical and Veterinary Entomology
https://www.readbyqxmd.com/read/28750867/west-nile-virus-infection-in-horses-indian-ocean
#11
E Cardinale, C Bernard, S Lecollinet, V M Rakotoharinome, J Ravaomanana, M Roger, M M Olive, D Meenowa, M R Jaumally, J Melanie, J M Héraud, S Zientara, C Cêtre-Sossah
The circulation of West Nile virus (WNV) in horses was investigated in the Southwest Indian ocean. In 2010, blood samples were collected from a total of 303 horses originating from Madagascar, Mauritius, Reunion and the Seychelles and tested for WNV-specific antibodies. An overall seroprevalence of 27.39% was detected in the Indian Ocean with the highest WNV antibody prevalence of 46.22% (95% CI: [37.4-55.2%]) in Madagascar. The age and origin of the horses were found to be associated with the WNV infection risk...
August 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/28748841/prevalence-of-igg-antibodies-for-the-west-nile-virus-in-human-population-in-tripoli-libya
#12
Taher Shaibi, Walid K Saadawi, H Aghila, Badereddin B Annajar
BACKGROUND & OBJECTIVES: West Nile fever (WNF) is a mosquito-borne viral infection, circulated in natural cycles between birds and mosquitoes, particularly Culex species. It is transmitted to humans through mosquito bites, and causes a variety of clinical outcomes, ranging from asymptomatic or mild febrile illness to severe men in go encepha- litis with some fatalities observed in older or immunocompromised patients. West Nile virus (WNV) transmission is considerably influenced by environmental conditions; and abundance of avifauna and mosquitoes...
April 2017: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/28746985/west-nile-virus-lineage-2-in-culex-specimens-from-iran
#13
Nariman Shahhosseini, Sadegh Chinikar, Seyed Hassan Moosa-Kazemi, Mohammad Mehdi Sedaghat, Mohammad Hassan Kayedi, Renke Lühken, Jonas Schmidt-Chanasit
OBJECTIVE: Screening of mosquitoes for viruses is an important forecasting tool for emerging and reemerging arboviruses. Iran has been known to harbor medically important arboviruses such as West Nile virus (WNV) and dengue virus (DENV) based on seroepidemiological data. However, there are no data about the potential mosquito vectors for arboviruses in Iran. This study was performed to provide mosquito and arbovirus data from Iran. MATERIALS AND METHODS: 32,317 mosquitos were collected at 16 sites in 5 provinces of Iran in 2015 and 2016...
July 26, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28744282/antiviral-properties-of-the-natural-polyphenols-delphinidin-and-epigallocatechin-gallate-against-the-flaviviruses-west-nile-virus-zika-virus-and-dengue-virus
#14
Ángela Vázquez-Calvo, Nereida Jiménez de Oya, Miguel A Martín-Acebes, Emilia Garcia-Moruno, Juan-Carlos Saiz
The Flavivirus genus contains important pathogens, such as West Nile virus (WNV), Zika virus (ZIKV), and Dengue virus (DENV), which are enveloped plus-strand RNA viruses transmitted by mosquitoes and constitute a worrisome threat to global human and animal health. Currently no licensed drugs against them are available, being, thus, still necessary the search for effective antiviral molecules. In this line, a novel antiviral approach (economical, simple to use, and environmental friendly) is the use of natural compounds...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28742857/dna-immunisation-with-dengue-virus-e-protein-domains-i-ii-but-not-domain-iii-enhances-zika-west-nile-and-yellow-fever-virus-infection
#15
Jose L Slon Campos, Monica Poggianella, Sara Marchese, Monica Mossenta, Jyoti Rana, Francesca Arnoldi, Marco Bestagno, Oscar R Burrone
Dengue virus (DENV), the causative agent of dengue disease, is among the most important mosquito-borne pathogens worldwide. DENV is composed of four closely related serotypes and belongs to the Flaviviridae family alongside other important arthropod-borne viral pathogens such as Zika virus (ZIKV), West Nile virus (WNV) and Yellow Fever virus (YFV). After infection, the antibody response is mostly directed to the viral E glycoprotein which is composed of three structural domains named DI, DII and DIII that share variable degrees of homology among different viruses...
2017: PloS One
https://www.readbyqxmd.com/read/28736681/integrating-environmental-monitoring-and-mosquito-surveillance-to-predict-vector-borne-disease-prospective-forecasts-of-a-west-nile-virus-outbreak
#16
Justin K Davis, Geoffrey Vincent, Michael B Hildreth, Lon Kightlinger, Christopher Carlson, Michael C Wimberly
INTRODUCTION: Predicting the timing and locations of future mosquito-borne disease outbreaks has the potential to improve the targeting of mosquito control and disease prevention efforts. Here, we present and evaluate prospective forecasts made prior to and during the 2016 West Nile virus (WNV) season in South Dakota, a hotspot for human WNV transmission in the United States. METHODS: We used a county-level logistic regression model to predict the weekly probability of human WNV case occurrence as a function of temperature, precipitation, and an index of mosquito infection status...
May 23, 2017: PLoS Currents
https://www.readbyqxmd.com/read/28727516/serological-survey-for-west-nile-virus-in-wild-artiodactyls-southern-moravia-czech-republic
#17
Zdenek Hubálek, Zina Juricová, Petra Straková, Hana Blazejová, Lenka Betásová, Ivo Rudolf
Antibodies to West Nile virus (WNV) were examined by plaque-reduction neutralization test in the blood sera of 1023 wild artiodactyls: 105 roe deer (Capreolus capreolus), 148 red deer (Cervus elaphus), 287 fallow deer (Dama dama), 71 mouflons (Ovis musimon), and 412 wild boars (Sus scrofa), sampled in South Moravian district of Breclav (Czech Republic) in the years 1990-2008. Neutralizing antibodies were detected in 5.9% of wild ruminants (4.8% roe deer, 4.1% red deer, 6.3% fallow deer, 9.9% mouflons) and 4...
July 20, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28726615/west-nile-virus-outbreak-in-houston-and-harris-county-texas-usa-2014
#18
Diana Martinez, Kristy O Murray, Martin Reyna, Raouf R Arafat, Roberto Gorena, Umair A Shah, Mustapha Debboun
Since 2002, West Nile virus (WNV) has been detected every year in Houston and the surrounding Harris County, Texas. In 2014, the largest WNV outbreak to date occurred, comprising 139 cases and causing 2 deaths. Additionally, 1,286 WNV-positive mosquito pools were confirmed, the most reported in a single mosquito season.
August 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28724737/stress-hormones-predict-a-host-superspreader-phenotype-in-the-west-nile-virus-system
#19
Stephanie S Gervasi, Sarah C Burgan, Erik Hofmeister, Thomas R Unnasch, Lynn B Martin
Glucocorticoid stress hormones, such as corticosterone (CORT), have profound effects on the behaviour and physiology of organisms, and thus have the potential to alter host competence and the contributions of individuals to population- and community-level pathogen dynamics. For example, CORT could alter the rate of contacts among hosts, pathogens and vectors through its widespread effects on host metabolism and activity levels. CORT could also affect the intensity and duration of pathogen shedding and risk of host mortality during infection...
July 26, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28722808/an-examination-of-the-effect-of-aerosolized-permanone-insecticide-on-zebra-finch-susceptibility-to-west-nile-virus
#20
Mark D Jankowski, Murray E Moore, Erik K Hofmeister
West Nile virus is primarily maintained cryptically primarily in avian (Passerine) populations where it is transmitted by Culex spp. mosquitoes. Mosquito control measures currently include physical activities to reduce mosquito breeding sites, the application of mosquito larvicides, or aerosolized insecticides to kill adults (adulticides) when arboviral diseases such as West Nile virus (WNV) or Zika virus are detected in mosquito populations. Organochlorine, organohosphorus, carbamate and pyrethroid insecticides are often used...
July 19, 2017: Environmental Toxicology and Chemistry
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