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https://www.readbyqxmd.com/read/29140933/t-spot-tb%C3%A2-performance-in-routine-pediatric-practice-in-a-low-tb-burden-setting
#1
Anna M Mandalakas, Heather Y Highsmith, Nadine M Harris, Anna Pawlicka, H Lester Kirchner
BACKGROUND: The T-SPOT.TB, an interferon-γ release assay (IGRA), is an indirect test of Mycobacterium tuberculosis infection. Due to sparse and conflicting evidence, IGRA use is limited in young and HIV-infected children. We determined the prevalence of invalid, borderline, positive, and negative results and associations with key demographic variables during routine pediatric use in a TB low-burden setting. METHODS: For pediatric samples received at Oxford Diagnostic Laboratories from 2010-2015, the associations between initial test outcome and demographics were estimated by bivariate analysis and logistic regression...
November 14, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29140800/glassy-magnetic-ground-state-and-kondo-like-behaviour-in-mn10fege8-alloy
#2
S Pramanick, P Dutta, S Majumdar, S Chatterjee
We report a detailed investigation of the ground-state magnetic properties of newly synthesized [Formula: see text] [Formula: see text] alloy. The sample can be thought of being derived by substituting one Mn atom by Fe of the parent compound [Formula: see text] [Formula: see text]. Fe-substitution leads to a drastic change in the magnetic ground state as well as to the magneto-transport properties of the parent alloy. On cooling below 250 K, [Formula: see text] [Formula: see text] undergoes a transition from paramagnetic phase to a state having significant ferromagnetic correlations...
November 15, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29140503/social-action-among-social-work-practitioners-examining-the-micro-macro-divide
#3
Nicole Olivia Mattocks
Social work is a profession that seeks to enhance the well-being of all people and promote social justice and social change through a range of activities, such as direct practice, community organizing, social and political action, and policy development. However, the current literature suggests that the profession's focus on social justice and social action are weakening, replaced by individualism and therapeutic interventions. This article examines data derived from a survey of 188 National Association of Social Workers members from Maryland; Virginia; and Washington, DC, to explore levels of social action participation among social workers and determine whether identifying as a macro-level practitioner would predict higher levels of social action activity compared with being a micro-level practitioner...
November 13, 2017: Social Work
https://www.readbyqxmd.com/read/29140443/dc-sign-polymorphisms-associated-with-risk-of-hepatitis-c-virus-infection-among-men-who-have-sex-with-men-but-not-among-injecting-drug-users
#4
Gaby S Steba, Sylvie M Koekkoek, Joost W Vanhommerig, Kees Brinkman, David Kwa, Jan T M Van Der Meer, Maria Prins, Ben Berkhout, Michael Tanck, William A Paxton, Richard Molenkamp, Janke Schinkel
We aimed to identify whether genetic polymorphisms within L-SIGN or DC-SIGN correlate with HCV susceptibility. An MSM and an IDU cohort of HCV cases and multiple-exposed uninfected controls were genotyped for numerous L-SIGN and DC-SIGN polymorphisms. DC-SIGN SNPs -139, -871 and -939 correlate with HCV acquisition in the MSM cohort only. When the same SNPs were introduced into a transcription activity assay they demonstrated a reduction in expression with predicted alteration in binding of transcription factors...
November 13, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29140141/short-clinical-examination-for-temporomandibular-symptoms-in-general-practice
#5
Christina Mejersjö, Ove Bertilsson, Karin Bäck
OBJECTIVE: The aims of the study are to assess the reliability of the short clinical examination, and to compare the information gained with a well-known and validated examination, the diagnostic criteria for temporomandibular disorders (DC/TMD). MATERIALS AND METHODS: The study comprises 52 consecutive, newly referred patients at their first visit and examination to an Orofacial Pain and TMD Clinic, 15 years and older, mean age 44 years. The patients first answered three screening questions for reported symptoms...
November 15, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/29138422/fam19a5-a-brain-specific-chemokine-inhibits-rankl-induced-osteoclast-formation-through-formyl-peptide-receptor-2
#6
Min Young Park, Hyung Sik Kim, Mingyu Lee, Byunghyun Park, Ha Young Lee, Eun Bee Cho, Jae Young Seong, Yoe-Sik Bae
Osteoclasts can be differentiated from bone marrow-derived macrophages (BMDM). They play a key role in bone resorption. Identifying novel molecules that can regulate osteoclastogenesis has been an important issue. In this study, we found that FAM19A5, a neurokine or brain-specific chemokine, strongly stimulated mouse BMDM, resulting in chemotactic migration and inhibition of RANKL-induced osteoclastogenesis. Expression levels of osteoclast-related genes such as RANK, TRAF6, OSCAR, TRAP, Blimp1, c-fos, and NFATc1 were markedly decreased by FAM19A5...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29138056/skin-specific-cd301b-dermal-dendritic-cells-drive-il-17-mediated-psoriasis-like-immune-response-in-mice
#7
Tae-Gyun Kim, Sung Hee Kim, Jeyun Park, Wanho Choi, Moah Sohn, Hye Young Na, Minseok Lee, Jae Won Lee, Soo Min Kim, Do-Young Kim, Hyoung-Pyo Kim, Jae-Hoon Choi, Chae Gyu Park, Min-Geol Lee
Conventional dendritic cells (cDCs) are composed of heterogeneous subsets commonly arising from DC-committed progenitors. A population of CD301b-expressing DCs has recently been identified in non-lymphoid barrier tissues such as skin. However, whether CD301b(+) DCs in the skin represent ontogenetically unique subpopulation of migratory cDCs has not been fully addressed. Here, we demonstrated that CD301b(+) dermal DCs were distinct subpopulation of FLT3L-dependent CD11b(+) cDC2 lineage which required an additional GM-CSF cue for the adequate development...
November 11, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29137960/ampa-receptor-translocation-and-phosphorylation-are-induced-by-transcranial-direct-current-stimulation-in-rats
#8
Justin Stafford, Milene L Brownlow, Anthony Qualley, Ryan Jankord
Over the last decade, the interest in transcranial direct current stimulation (tDCS) has continued to increase, along with consideration of how it affects neuroplasticity mechanisms in the brain. Both human and animal studies have demonstrated numerous benefits and, although its application has increased, the neurophysiological mechanisms underlying tDCS' beneficial effects remain largely unknown. Recent studies have shown that long-term potentiation (LTP) increases following tDCS. In this work, we utilized a rodent model of tDCS to directly assess changes in the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor, a critical protein for enhancing synaptic transmission...
November 11, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29136520/characterization-of-myeloid-cell-populations-in-human-testes-collected-after-sex-reassignment-surgery
#9
Rosalie Ponte, Franck P Dupuy, Fadi Brimo, Vikram Mehraj, Pierre Brassard, Maud Belanger, Ekaterina Yurchenko, Mohammad-Ali Jenabian, Nicole F Bernard, Jean-Pierre Routy
The testis has been described in animal models as a site of immune privilege, which protects spermatids against tissue damage during inflammation. Myeloid cells, including macrophages and dendritic cells (DC), are defined as key players in the testicular immune privilege in animal models. However, their distribution and frequency in human testis remain poorly described. To overcome the challenges related to tissue sampling, we obtained testicular tissue from men under hormonal therapy who elected to have sex reassignment surgery (SRS)...
October 14, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29135371/follistatin-like-protein-1-upregulates-dendritic-cell-based-immunity-in-patients-with-nasopharyngeal-carcinoma
#10
Hong Wang, Shiping Huang, Senyong Wu, Shaolin Yin, Anzhou Tang, Wensheng Wen
Follistatin-like protein-1 (FSTL1) is an inflammatory factor that can induce an inflammatory response and is expressed in cancers. However, little is known about its content and function in nasopharyngeal carcinoma (NPC). Interleukin (IL)-12 and IL-4 are primarily secreted by dendritic cells (DCs) and activated T lymphocytes, respectively; these factors can induce Th cell differentiation and cytotoxic lymphocyte production, both of which facilitate tumors through the STAT4 and STAT6 pathways, respectively. In this study, the relationship between FSTL1 and both IL-12 and IL-4 as well as the functional mechanism of these cytokines was explored...
November 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/29135060/a-study-to-determine-the-prevalence-of-temporomandibular-disorders-in-a-young-adult-population-and-its-association-with-psychological-and-functional-occlusal-parameters
#11
Hemant Maheshkumar Jivnani, Shuchi Tripathi, Rama Shanker, Balendra Pratap Singh, Kaushal Kishor Agrawal, Rameshwari Singhal
PURPOSE: To determine the prevalence of temporomandibular disorders (TMD) in medical university students and to analyze the relationship of TMD with psychological and functional occlusal parameters. MATERIALS AND METHODS: 200 students (mean age 21.81 ± 1.99) were screened for TMD with the TMD Pain Screener. Clinical examinations identified the participants with TMD. Based on their diagnostic criteria for TMD (DC/TMD) axis I diagnosis, participants were divided into three groups: group 1- non-TMD, group 2- pain related TMD and headaches, and group 3- intra-articular joint disorders...
November 14, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29134690/faecal-calcium-excretion-does-not-decrease-during-long-term-feeding-of-a-low-calcium-diet-in-adult-dogs
#12
S Schmitt, J Mack, E Kienzle, L G Alexander, P J Morris, A Colyer, B Dobenecker
According to a previous meta-analysis, adult dogs do not notably increase calcium absorption from the gastrointestinal tract when calcium intake is decreased. This results in a negative calcium balance even with a moderate calcium reduction. In this study we wanted to verify (i) whether a negative calcium balance occurs at a calcium intake equivalent to NRC (2006) (Nutrient requirements of dogs and cats, 2006, The National Academies Press, Washington, DC) minimal requirements, and if so (ii) whether the negative calcium balance will persist for up to 6 months on a low-calcium diet...
November 13, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29134568/%C3%AE-2-adrenergic-stimulation-of-dendritic-cells-favors-il-10-secretion-by-cd4-t-cells
#13
Julie Hervé, Karine Haurogné, Elodie Bacou, Sylvie Pogu, Marie Allard, Grégoire Mignot, Jean-Marie Bach, Blandine Lieubeau
Adrenergic receptor agonists and antagonists are extensively used as drugs in medicine for a broad spectrum of indications. We examined the consequences of β2-adrenergic stimulation of murine dendritic cells (DCs) on CD4(+) T cell activation. We demonstrated in vitro that treatment of LPS-matured DCs with the β2-agonist salbutamol reduced their ability to trigger OT-II T cell proliferation specific for ovalbumin antigen. Salbutamol also induced a decrease in MHC class II molecule expression by DC through Gi protein activation...
November 14, 2017: Immunologic Research
https://www.readbyqxmd.com/read/29134413/comparison-of-feature-evaluation-criteria-for-speech-recognition-based-on-electromyography
#14
Niyawadee Srisuwan, Pornchai Phukpattaranont, Chusak Limsakul
In this paper, we present a performance comparison of 14 feature evaluation criteria and 4 classifiers for isolated Thai word classification based on electromyography signals (EMG) to find a near-optimal criterion and classifier. Ten subjects spoke 11 Thai number words in both audible and silent modes while the EMG signal from five positions of the facial and neck muscles were captured. After signal collection and preprocessing, 22 EMG features widely used in the EMG recognition field were computed and were then evaluated based on 14 evaluation criteria including both independent criteria (IC) and dependent criteria (DC) for feature evaluation and selection...
November 14, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29134199/rapid-directed-transport-of-dc-sign-clusters-in-the-plasma-membrane
#15
Ping Liu, Violetta Weinreb, Marc Ridilla, Laurie Betts, Pratik Patel, Aravinda M de Silva, Nancy L Thompson, Ken Jacobson
C-type lectins, including dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), are all-purpose pathogen receptors that exist in nanoclusters in plasma membranes of dendritic cells. A small fraction of these clusters, obvious from the videos, can undergo rapid, directed transport in the plane of the plasma membrane at average speeds of more than 1 μm/s in both dendritic cells and MX DC-SIGN murine fibroblasts ectopically expressing DC-SIGN. Surprisingly, instantaneous speeds can be considerably greater...
November 2017: Science Advances
https://www.readbyqxmd.com/read/29133913/nitric-oxide-mediated-inhibition-of-antigen-presentation-from-dcs-to-cd4-t-cells-in-cancer-and-measurement-of-stat1-nitration
#16
Joseph Markowitz, Jiang Wang, Zach Vangundy, Jia You, Vedat Yildiz, Lianbo Yu, Isaac P Foote, Owen E Branson, Andrew R Stiff, Taylor R Brooks, Brandon Biesiadecki, Thomas Olencki, Susheela Tridandapani, Michael A Freitas, Tracey Papenfuss, Mitch A Phelps, William E Carson
Myeloid derived suppressor cells (MDSC) produce nitric oxide (NO) and inhibit dendritic cell (DC) immune responses in cancer. DCs present cancer cell antigens to CD4(+) T cells through Jak-STAT signal transduction. In this study, NO donors (SNAP and DETA-NONOate) inhibited DC antigen presentation. As expected, MDSC isolated from peripheral blood mononuclear cells (PBMC) from cancer patients produced high NO levels. We hypothesized that NO producing MDSC in tumor-bearing hosts would inhibit DC antigen presentation...
November 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29133346/mycobacterium-tuberculosis-groel2-modulates-dendritic-cell-responses
#17
Maria Georgieva, Jonathan Kevin Sia, Erica Bizzell, Ranjna Madan-Lala, Jyothi Rengarajan
Mycobacterium tuberculosis (Mtb) successfully subverts the host immune response to promote disease progression. In addition to its known intracellular niche in macrophages, Mtb interferes with the functions of dendritic cells (DCs), which are the primary antigen presenting cells in the immune system. We previously showed that Mtb dampens proinflammatory responses and impairs DC functions through the cell envelope-associated serine protease, Hip1. Here we present data showing that Mtb GroEL2, a substrate of Hip1, modulates DC functions...
November 13, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29133229/use-of-electrical-penetration-graphs-epg-and-quantitative-pcr-to-evaluate-the-relationship-between-feeding-behaviour-and-pandora-neoaphidis-infection-levels-in-green-peach-aphid-myzus-persicae
#18
Chun Chen, Sudan Ye, Huajun Hu, Chengmei Xue, Xiaoping Yu
A real-time qPCR method was developed, validated, and used to quantity the fungal pathogen, P. neoaphidis, within aphids at different times during infection; colonization rate fitted the Gompertz model well (R(b)=0.9356). Feeding behaviour of P. neoaphidis-infected and uninfected M. persicae were investigated, for the first time, using DC-electrical penetration graphs (DC-EPG) that characterized the waveforms made during different aphid stylet probing periods corresponding to epidermis penetration, salivation and ingestion...
November 10, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/29132999/radiologists-and-social-media-do-not-forget-about-facebook
#19
Rebecca L Seidel, Aryan Jalilvand, Jean Kunjummen, Lea Gilliland, Richard Duszak
PURPOSE: Facebook (Facebook, Inc, Menlo Park, California, USA) is the most popular social networking platform worldwide. Facebook groups are virtual communities of people who share a common interest. Breast Imaging Radiologists is a Facebook group for radiologists with an interest in breast imaging. The purpose of this study was to analyze the membership and activity of the Breast Imaging Radiologists Facebook group (BIRFG) for 2 years since its inception. METHODS: Using both the Grytics (www...
November 11, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29132922/physical-and-chemical-properties-of-model-composites-containing-quaternary-ammonium-methacrylates
#20
Marina Lermenn Vidal, Guilherme Ferreira Rego, Gil Mendes Viana, Lucio Mendes Cabral, Juliana Primo Basílio Souza, Nick Silikas, Luis Felipe Schneider, Larissa Maria Cavalcante
OBJECTIVE: Investigate physical and chemical properties of model composites formulated with quaternary ammonium salt monomers (QAS) at different concentrations and alkyl chains lengths METHODS: QAS with 12 dimethylaminododecyl methacrylate (DMADDM) and 16 dimethylaminohexadecyl methacrylate (DMAHDM) chains lengths were synthesized and incorporated at 5 and 10% in model composites, resulting in four groups: G12.5 (DMADDM 5%), G12.10 (DMADDM 10%), G16.5 (DMAHDM 5%), G16.10 (DMAHDM 10%)...
November 10, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
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