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https://www.readbyqxmd.com/read/29467932/characterization-of-aptamer-mediated-gene-delivery-system-for-liver-cancer-therapy
#1
Zhongbing Liu, Xiaoduan Sun, Shuangli Xiao, Yan Lin, Chunhong Li, Na Hao, Meiling Zhou, Ruolan Deng, Siyun Ke, Zhirong Zhong
Liver cancer is a fatal disease with limited therapy options. The recombinant adenovirus expressing tumor-suppressor gene of PTEN (Ad5-PTEN) showed effective antitumor activity against liver cancer. However, its disadvantages produced great limitation on its application, especially its nonspecific and toxicity to normal cells and tissues. The epithelial cell adhesion molecule (EpCAM) is over-expressed in some liver cancer cells and an RNA aptamer EpDT3 could specially target to EpCAM-positive cells. Based on this founding, we aimed to design a kind of gene delivery system of EpDT3-mediated Ad5-PTEN (EpDT3-PEG-Ad5-PTEN, EPAP) in which polyethylene glycol was used to be a linker to conjugate EpDT3 with Ad5-PTEN...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29460489/exercise-induced-pulmonary-hemorrhage-in-barrel-racing-horses-in-the-pacific-northwest-region-of-the-united-states
#2
Jenifer R Gold, Donald P Knowles, Todd Coffey, Warwick M Bayly
BACKGROUND: Exercise-induced pulmonary hemorrhage (EIPH) refers to bleeding from the lungs in association with strenuous exercise. It has been documented in race horses but little information exists on EIPH in barrel racing horses. HYPOTHESIS/OBJECTIVES: Our goals were to evaluate the presence of EIPH in barrel racing horses and estimate its prevalence in the Pacific Northwest. ANIMALS: 149 barrel racing horses enrolled at events in WA (11), ID (3), and MT (33)...
February 20, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29397225/second-five-year-follow-up-after-a-booster-vaccination-against-tick-borne-encephalitis-following-different-primary-vaccination-schedules-demonstrates-at-least-10%C3%A2-years-antibody-persistence
#3
Jiri Beran, Maria Lattanzi, Fang Xie, Luca Moraschini, Ilaria Galgani
BACKGROUND: Tick borne encephalitis (TBE) endemic zones are expanding. We previously evaluated long term persistence of antibody 5 years after the first booster immunization following different primary immunization schedules with the polygeline-free inactivated TBE vaccine (TBEvac) in adults and adolescents. Here, we report anti-TBE virus (TBEV) antibody persistence from 6 to 10 years post-booster administration. METHODS: This was a phase IV, open-label, single-center, second extension study (NCT01562444), conducted in Czechia...
January 31, 2018: Vaccine
https://www.readbyqxmd.com/read/29337197/brain-perfusion-alterations-in-tick-borne-encephalitis-preliminary-report
#4
Zuzanna Tyrakowska-Dadełło, Eugeniusz Tarasów, Dariusz Janusek, Anna Moniuszko-Malinowska, Joanna Zajkowska, Sławomir Pancewicz
BACKGROUND: Magnetic resonance imaging (MRI) changes in tick-borne encephalitis (TBE) are non-specific and the pathophysiological mechanisms leading to their formation remain unclear. This study investigated brain perfusion in TBE patients using dynamic susceptibility-weighted contrast-enhanced magnetic resonance perfusion imaging (DSC-MRI perfusion). METHODS: MRI scans were performed for 12 patients in the acute phase, 3-5days after the diagnosis of TBE. Conventional MRI and DSC-MRI perfusion studies were performed...
January 11, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29313244/meningoencephaloradiculitis-following-infection-with-tick-borne-encephalitis-virus-case-report-and-review-of-the-literature
#5
Stephanie Du Four, Rembert Mertens, Wietse Wiels, Jacques De Keyser, Veronique Bissay, Anja Flamez
Tick borne encephalitis (TBE) is an infectious zoonotic disease caused by an RNA virus that is endemic to Central and Eastern Europe, Russia, and large parts of Asia. The tick borne encephalitis virus (TBEV) is transmitted through the saliva of infected ticks and infected goat milk. In the vast majority of cases, an infection with TBEV has a subclinical course. However, in some cases, it leads to neurological symptoms due to meningitis, meningoencephalitis, meningoencephalomyelitis, or meningoencephaloradiculitis...
January 8, 2018: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29300080/mineralogical-controls-on-the-bioaccessibility-of-arsenic-in-fe-iii-as-v-coprecipitates
#6
Katrin Ehlert, Christian Mikutta, Yuan Jin, Ruben Kretzschmar
X-ray amorphous Fe(III)-As(V) coprecipitates are common initial products of oxidative As- and Fe-bearing sulfide weathering, and often control As solubility in mine wastes or mining-impacted soils. The formation conditions of these solids may exert a major control on their mineralogical composition and, hence, As release in the gastric tract of humans after incidental ingestion of As-contaminated soil. Here, we synthesized a set of 35 Fe(III)-As(V) coprecipitates as a function of pH (1.5-8) and initial molar Fe/As ratio (0...
January 4, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29279742/prevalence-and-complications-of-postoperative-transfusion-for-cervical-fusion-procedures-in-spine-surgery-an-analysis-of-11-588-patients-from-the-american-college-of-surgeons-national-surgical-quality-improvement-program-database
#7
Ahmed Aoude, Sultan Aldebeyan, Maryse Fortin, Anas Nooh, Peter Jarzem, Jean A Ouellet, Michael H Weber
Study Design: Retrospective cohort study. Purpose: The purpose of this study was to assess the rate of blood transfusion after cervical fusion surgery, and its effect on complication rates. Overview of Literature: Cervical spine fusions have gained interest in the literature since these procedures are now ever more frequently being performed in an outpatient setting with few complications. Methods: The American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database was used to identify patients that underwent cervical fusion from 2010 to 2013...
December 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/29275872/the-long-term-outcome-of-tick-borne-encephalitis-in-central-europe
#8
Petra Bogovič, Daša Stupica, Tereza Rojko, Stanka Lotrič-Furlan, Tatjana Avšič-Županc, Andrej Kastrin, Lara Lusa, Franc Strle
BACKGROUND: Information on the long-term outcome of tick-borne encephalitis (TBE) is limited. OBJECTIVES: To assess the frequency and severity of post-encephalitic syndrome (PES) at different time points after TBE, and to determine the parameters associated with unfavourable outcome. METHODS: Adult patients diagnosed with TBE in Slovenia in the period 2007-2012 were followed-up for 12 months and also examined 2-7 years after TBE. Each patient was asked to refer a person of similar age without a history of TBE to serve as control...
December 6, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29188467/diagnosing-tick-borne-encephalitis-a-re-evaluation-of-notified-cases
#9
Malin Veje, Marie Studahl, Maja Johansson, Patrik Johansson, Peter Nolskog, Tomas Bergström
We set out to investigate the serological response of TBE virus (TBEV)-specific IgM and IgG antibodies in stored serum and cerebrospinal fluid (CSF) in notified TBE patients, in order to confirm or reject the diagnosis. We applied the ELISA methods used in clinical practice, Enzygnost and Immunozym, and assessed RT-PCR as a diagnostic tool. A total of 173 TBE cases were notified to the Public Health Agency. Samples from 129 patients were eligible for the study. Stored serum samples were found for 111 patients and CSF samples for 88 patients...
November 29, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29181672/seasonal-cycles-of-the-tbe-and-lyme-borreliosis-vector-ixodes-ricinus-modelled-with-time-lagged-and-interval-averaged-predictors
#10
Katharina Brugger, Melanie Walter, Lidia Chitimia-Dobler, Gerhard Dobler, Franz Rubel
Ticks of the species Ixodes ricinus (L.) are the major vectors for tick-borne diseases in Europe. The aim of this study was to quantify the influence of environmental variables on the seasonal cycle of questing I. ricinus. Therefore, an 8-year time series of nymphal I. ricinus flagged at monthly intervals in Haselmühl (Germany) was compiled. For the first time, cross correlation maps were applied to identify optimal associations between observed nymphal I. ricinus densities and time-lagged as well as temporal averaged explanatory variables...
November 27, 2017: Experimental & Applied Acarology
https://www.readbyqxmd.com/read/29156399/saliva-of-ixodes-ricinus-enhances-tbe-virus-replication-in-dendritic-cells-by-modulation-of-pro-survival-akt-pathway
#11
Jaroslava Lieskovská, Jana Páleníková, Helena Langhansová, Jindřich Chmelař, Jan Kopecký
It has been suggested that tick saliva facilitates transmission of tick-borne encephalitis virus (TBEV) to vertebrates. The mechanism of this facilitation has not been elucidated yet. Since dendritic cells (DCs) are among first cells attacked by the virus, we examined the amount of virus and changes induced by saliva in TBEV-infected DCs. We found that virus replication was significantly increased by saliva of Ixodes ricinus tick. Next, saliva-induced enhancement of Akt pathway activation was observed in TBEV-infected DCs...
November 17, 2017: Virology
https://www.readbyqxmd.com/read/29105605/the-feasibility-of-an-acute-high-intensity-exercise-bout-to-promote-locomotor-learning-after-stroke
#12
Charalambos C Charalambous, Erin E Helm, Kristin A Lau, Susanne M Morton, Darcy S Reisman
BACKGROUND: People post-stroke can learn a novel locomotor task but require more practice to do so. Implementing an approach that can enhance locomotor learning may therefore improve post-stroke locomotor recovery. In healthy adults, an acute high-intensity exercise bout before or after a motor task may improve motor learning and has thus been suggested as a method that could be used to improve motor learning in neurorehabilitation. However, it is unclear whether an acute high-intensity exercise bout, which stroke survivors can feasibly complete in neurorehabilitation session, would generate comparable results...
November 5, 2017: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/29064333/molecular-detection-and-serological-evidence-of-tick-borne-encephalitis-virus-in-serbia
#13
Aleksandar Potkonjak, Tamaš Petrović, Elizabeta Ristanović, Ivica Lalić, Vuk Vračar, Sara Savić, Vesna Turkulov, Grozdana Čanak, Vesna Milošević, Dejan Vidanović, Aleksandar Jurišić, Aleksandra Petrović, Vladimir Petrović
Tick-borne encephalitis (TBE) is a zoonotic flaviviral infection that is a growing public health concern in European countries. The aims of this research were to detect and characterize tick-borne encephalitis virus (TBEV) in Ixodes ricinus ticks at presumed natural foci in Serbia, and to determine seroprevalence of TBEV IgG antibodies in humans and animals. A total of 500 I. ricinus ticks were examined for the presence of TBEV by real-time RT-PCR, and conventional nested PCR and sequencing. To determine TBEV seroprevalence, 267 human sera samples were collected, as were 200 sera samples from different animal species...
October 24, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29053888/epidemiological-patterns-of-tick-borne-encephalitis-in-lithuania-and-clinical-features-in-adults-in-the-light-of-the-high-incidence-in-recent-years-a-retrospective-study
#14
Daiva Radzišauskienė, Kęstutis Žagminas, Loreta Ašoklienė, Arminas Jasionis, Rūta Mameniškienė, Arvydas Ambrozaitis, Ligita Jančorienė, Dalius Jatužis, Iveta Petraitytė, Evelina Mockienė
BACKGROUND: Lithuania is one of the countries with the highest incidence of TBE in Europe. The aim of this study was to describe the epidemiological patterns of TBE in Lithuania, and characterize clinical features in adults in the light of the high incidence in recent years. METHODS: Surveillance data available on the website of the Center for Communicable Diseases and AIDS of Lithuania were used to describe the epidemiological patterns of TBE. The retrospective study included 712 patients hospitalized in the Center for Infectious Diseases and the Center for Neurology of Vilnius University in the years 2005-2014...
October 20, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29053401/are-we-prepared-for-emerging-flaviviruses-in-europe-challenges-for-vaccination
#15
Patricia Kaaijk, Willem Luytjes
Tick-borne encephalitis and West Nile fever are endemic flavivirus diseases in Europe. Climate change, virus evolution, and social factors may increase the risk of these flavivirus infections and may lead to the emergence of other flaviviruses in Europe that are endemic in (sub)tropical regions of the world. Control of the spread of flaviviruses is very difficult considering the cycling of flaviviruses between arthropod vectors and animal reservoir hosts. The increasing threat of flavivirus infections emphasizes the necessity of a sustainable vector surveillance system, an active animal health surveillance system and an adequate human surveillance system for early detection of flavivirus infections...
October 20, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29017579/surveillance-of-ixodes-ricinus-ticks-acari-ixodidae-in-iceland
#16
Matthias Alfredsson, Erling Olafsson, Matthias Eydal, Ester Rut Unnsteinsdottir, Kayleigh Hansford, William Wint, Neil Alexander, Jolyon M Medlock
BACKGROUND: Ixodes ricinus is a three-host tick, a principal vector of Borrelia burgdorferi (s.l.) and one of the main vectors of tick-borne encephalitis (TBE) virus. Iceland is located in the North Atlantic Ocean with subpolar oceanic climate. During the past 3-4 decades, average temperature has increased, supporting more favourable conditions for ticks. Reports of I. ricinus have increased in recent years. If these ticks were able to establish in a changing climate, Iceland may face new threats posed by tick-borne diseases...
October 10, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28988602/a-new-hot-spot-for-tick-borne-encephalitis-tbe-a-marked-increase-of-tbe-cases-in-france-in-2016
#17
Aurélie Velay, Morgane Solis, Wallys Kack-Kack, Pierre Gantner, Marianne Maquart, Martin Martinot, Olivier Augereau, Dominique De Briel, Pierre Kieffer, Caroline Lohmann, Jean Dominique Poveda, Emmanuelle Cart-Tanneur, Xavier Argemi, Isabelle Leparc-Goffart, Sylvie de Martino, Benoit Jaulhac, Sophie Raguet, Marie-Josée Wendling, Yves Hansmann, Samira Fafi-Kremer
OBJECTIVES: Tick-borne encephalitis virus (TBEV) is a zoonotic agent causing severe encephalitis. In 2016, in Northeastern France, we faced a TBEV infection increase, leading to a warning from the Regional Health Agency. Here, we report the confirmed TBE cases diagnosed between January 2013 and December 2016, with particular emphasis on the year 2016. METHODS: A total of 1643 blood and cerebrospinal fluid (CSF) samples from everywhere in France, corresponding to 1460 patients, were prospectively tested for anti-TBEV-specific IgM and IgG antibodies by ELISA...
September 28, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28987410/variable-dual-carbon-bromine-stable-isotope-fractionation-during-enzyme-catalyzed-reductive-dehalogenation-of-brominated-ethenes
#18
Angela Woods, Kevin Kuntze, Faina Gelman, Ludwik Halicz, Ivonne Nijenhuis
The potential of compound-specific stable isotope analysis (CSIA) to characterize biotransformation of brominated organic compounds (BOCs) was assessed and compared to chlorinated analogues. Sulfurospirillum multivorans and Desulfitobacterium hafniense PCE-S catalyzed the dehalogenation of tribromoethene (TBE) to either vinyl bromide (VB) or ethene, respectively. Significantly lower isotope fractionation was observed for TBE dehalogenation by S. multivorans (εC = -1.3 ± 0.2‰) compared to D. hafniense (εC = -7...
September 27, 2017: Chemosphere
https://www.readbyqxmd.com/read/28928417/tick-borne-encephalitis-in-japan-republic-of-korea-and-china
#19
REVIEW
Kentaro Yoshii, Joon Young Song, Seong-Beom Park, Junfeng Yang, Heinz-Josef Schmitt
Tick-borne encephalitis virus (TBEV) causes mild or moderate febrile illness in humans that may progress to encephalitis, leading to severe long-term complications and sometimes death. TBEV is prevalent in the Eurasian continent and has been isolated in China, Japan and Republic of Korea (ROK). The TBEV isolates from Japan are of the Far-Eastern subtype; in ROK, the isolates are of the Western subtype; and all TBEV isolates in China are of the Far-Eastern subtype, except one strain that was identified most recently as the Siberian subtype...
September 20, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28921929/tumor-suppressive-mir-145-co-repressed-by-tcf4-%C3%AE-catenin-and-prc2-complexes-forms-double-negative-regulation-loops-with-its-negative-regulators-in-colorectal-cancer
#20
Wei Wang, Xin Xiao, Xu Chen, Yi Huo, Wen-Jin Xi, Zhi-Feng Lin, Dan Zhang, Yu-Fang Li, Fan Yang, Wei-Hong Wen, An-Gang Yang, Tao Wang
The frequently dysregulated Wnt/β-catenin signaling in different malignancies, by activation of its own or orchestration with other co-factors, regulates various oncogenic or tumor-suppressive genes. Among these genes, miRNAs, which are negative posttranscriptional regulators, are also embedded in the Wnt signaling network. Different from the Wnt-induced oncogenic miRNAs, the specific mechanism underlying the Wnt-repressed tumor-suppressive miRNAs is much less understood. In our study, firstly by analyzing a ChIP-seq dataset against TCF4, the core transcription factor for initiation of Wnt signaling in colorectal cancer (CRC) cells, we screened out several tumor-suppressive miRNAs potentially regulated by Wnt signaling...
September 16, 2017: International Journal of Cancer. Journal International du Cancer
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