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https://www.readbyqxmd.com/read/28202075/tick-borne-pathogens-induce-differential-expression-of-genes-promoting-cell-survival-and-host-resistance-in-ixodes-ricinus-cells
#1
Karen L Mansfield, Charlotte Cook, Richard J Ellis, Lesley Bell-Sakyi, Nicholas Johnson, Pilar Alberdi, José de la Fuente, Anthony R Fooks
BACKGROUND: There has been an emergence and expansion of tick-borne diseases in Europe, Asia and North America in recent years, including Lyme disease, tick-borne encephalitis and human anaplasmosis. The primary vectors implicated are hard ticks of the genus Ixodes. Although much is known about the host response to these bacterial and viral pathogens, there is limited knowledge of the cellular responses to infection within the tick vector. The bacterium Anaplasma phagocytophilum is able to bypass apoptotic processes in ticks, enabling infection to proceed...
February 15, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28159412/new-tools-in-nucleoside-toolbox-of-tick-borne-encephalitis-virus-reproduction-inhibitors
#2
Alexey A Orlov, Mikhail S Drenichev, Vladimir E Oslovsky, Nikolay N Kurochkin, Pavel N Solyev, Liubov I Kozlovskaya, Vladimir A Palyulin, Galina G Karganova, Sergey N Mikhailov, Dmitry I Osolodkin
Design and development of nucleoside analogs is an established strategy in the antiviral drug discovery field. Nevertheless, for many viruses the coverage of structure-activity relationships (SAR) in the nucleoside chemical space is not sufficient. Here we present the nucleoside SAR exploration for tick-borne encephalitis virus (TBEV), a member of Flavivirus genus. Promising antiviral activity may be achieved by introduction of large hydrophobic substituents in the position 6 of adenosine or bulky silyl groups to the position 5'...
January 14, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28153052/distribution-and-molecular-characteristics-of-rickettsiae-found-in-ticks-across-central-mongolia
#3
Bazartseren Boldbaatar, Rui-Ruo Jiang, Michael E von Fricken, Sukhbaatar Lkhagvatseren, Pagbajab Nymadawa, Bekhochir Baigalmaa, Ya-Wei Wang, Benjamin D Anderson, Jia-Fu Jiang, Gregory C Gray
BACKGROUND: Little is known regarding tick-borne diseases in Mongolia, despite having 26% of the population still living nomadic pastoral lifestyles. A total of 1497 adult unfed ticks: 261 Ixodes persulcatus, 795 Dermacentor nuttalli, and 441 Hyalomma asiaticum, were collected from three ecologically distinct regions in Central Mongolia. Tick pools (n = 299) containing ~5 ticks each, were tested for Rickettsia and Tick-borne encephalitis virus (TBEV) using nested polymerase chain reaction, reverse transcription-PCR, and quantitative real-time RT-PCR...
February 2, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28073402/deep-sequencing-analysis-of-tick-borne-encephalitis-virus-from-questing-ticks-at-natural-foci-reveals-similarities-between-quasispecies-pools-of-the-virus
#4
Naveed Asghar, John H-O Pettersson, Patrik Dinnetz, Åshild Andreassen, Magnus Johansson
Every year, tick-borne encephalitis virus (TBEV) causes severe central nervous system infection in 10,000 to 15,000 people in Europe and Asia. TBEV is maintained in the environment by an enzootic cycle that requires a tick vector and a vertebrate host, and the adaptation of TBEV to vertebrate and invertebrate environments is essential for TBEV persistence in nature. This adaptation is facilitated by the error-prone nature of the virus' RNA-dependent RNA polymerase that generates genetically distinct virus variants called quasispecies...
January 10, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28036247/intracellular-degradation-and-localization-of-ns1-of-tbev-affects-its-protective-properties
#5
Yulia Kuzmenko, Elizaveta Starodubova, Anastasia Shevtsova, Lubov Chernokhaeva, Anastasia Latanova, Olga Preobrazhenskaia, Andrey Timofeev, Galina Karganova, Vadim Karpov
Currently many DNA vaccines against infectious diseases are in clinical trials however their efficacy is needed to be improved. Potency of DNA immunogen can be optimized by targeting technologies. In a current study to increase the efficacy of NS1encoded by plasmid the proteasome targeting was applied. NS1 variants with or without translocation sequence and with signal of proteasomal degradation of ornithine decarboxylase were tested for expression, localization, protein turnover, proteasomal degradation and protection properties...
December 30, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27982069/the-role-of-the-poly-a-tract-in-the-replication-and-virulence-of-tick-borne-encephalitis-virus
#6
Naveed Asghar, Yi-Ping Lee, Emma Nilsson, Richard Lindqvist, Wessam Melik, Andrea Kröger, Anna K Överby, Magnus Johansson
The tick-borne encephalitis virus (TBEV) is a flavivirus transmitted to humans, usually via tick bites. The virus causes tick-borne encephalitis (TBE) in humans, and symptoms range from mild flu-like symptoms to severe and long-lasting sequelae, including permanent brain damage. It has been suggested that within the population of viruses transmitted to the mammalian host, quasispecies with neurotropic properties might become dominant in the host resulting in neurological symptoms. We previously demonstrated the existence of TBEV variants with variable poly(A) tracts within a single blood-fed tick...
December 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27977670/serological-evidence-of-contrasted-exposure-to-arboviral-infections-between-islands-of-the-union-of-comoros-indian-ocean
#7
Koussay Dellagi, Nicolas Salez, Marianne Maquart, Sophie Larrieu, Amina Yssouf, Rahamatou Silaï, Isabelle Leparc-Goffart, Pablo Tortosa, Xavier de Lamballerie
A cross sectional serological survey of arboviral infections in humans was conducted on the three islands of the Union of Comoros, Indian Ocean, in order to test a previously suggested contrasted exposure of the three neighboring islands to arthropod-borne epidemics. Four hundred human sera were collected on Ngazidja (Grande Comore), Mwali (Mohéli) and Ndzouani (Anjouan), and were tested by ELISA for IgM and/or IgG antibodies to Dengue (DENV), Chikungunya (CHIKV), Rift Valley fever (RVFV), West Nile (WNV), Tick borne encephalitis (TBEV) and Yellow fever (YFV) viruses and for neutralizing antibodies to DENV serotypes 1-4...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27884572/tick-borne-encephalitis-virus-neutralization-by-high-dose-intravenous-immunoglobulin
#8
Jana Elsterova, Martin Palus, Jana Sirmarova, Jan Kopecky, Hans Helmut Niller, Daniel Ruzek
Tick-borne encephalitis (TBE) is a potentially lethal neuroinfection in humans, caused by TBE virus (TBEV). Currently, there are no approved therapeutic agents to treat TBE. Previously, it was suggested that application of high dose intravenous immunoglobulin (IVIG) may pose potentially successful treatment for severe cases of TBE. In this study, we determined the titers of TBEV-neutralizing antibodies in two IVIG lots originating from the same manufacturer, and tested their ability to treat a lethal TBEV-infection in a mouse model...
November 18, 2016: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/27875810/nonstructural-protein-1-of-tick-borne-encephalitis-virus-induces-oxidative-stress-and-activates-antioxidant-defense-by-the-nrf2-are-pathway
#9
Yulia V Kuzmenko, Olga A Smirnova, Alexander V Ivanov, Elizaveta S Starodubova, Vadim L Karpov
BACKGROUND: Infection with tick-borne encephalitis virus (TBEV) causes pathological changes in the central nervous system. However, the possible redox alterations in the infected cells that can contribute to the virus pathogenicity remain unknown. OBJECTIVE: In the current study we explored the ability of TBEV nonstructural protein 1 (NS1) to induce oxidative stress and activate antioxidant defense via the nuclear factor (erythroid-derived-2)-like 2/antioxidant response element (Nrf2/ARE) pathway...
2016: Intervirology
https://www.readbyqxmd.com/read/27776548/fast-type-i-interferon-response-protects-astrocytes-from-flavivirus-infection-and-virus-induced-cytopathic-effects
#10
Richard Lindqvist, Filip Mundt, Jonathan D Gilthorpe, Silke Wölfel, Nelson O Gekara, Andrea Kröger, Anna K Överby
BACKGROUND: Neurotropic flaviviruses such as tick-borne encephalitis virus (TBEV), Japanese encephalitis virus (JEV), West Nile virus (WNV), and Zika virus (ZIKV) are causative agents of severe brain-related diseases including meningitis, encephalitis, and microcephaly. We have previously shown that local type I interferon response within the central nervous system (CNS) is involved in the protection of mice against tick-borne flavivirus infection. However, the cells responsible for mounting this protective response are not defined...
October 24, 2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27760182/revisiting-recombination-signal-in-the-tick-borne-encephalitis-virus-a-simulation-approach
#11
Yann J K Bertrand, Magnus Johansson, Peter Norberg
The hypothesis of wide spread reticulate evolution in Tick-Borne Encephalitis virus (TBEV) has recently gained momentum with several publications describing past recombination events involving various TBEV clades. Despite a large body of work, no consensus has yet emerged on TBEV evolutionary dynamics. Understanding the occurrence and frequency of recombination in TBEV bears significant impact on epidemiology, evolution, and vaccination with live vaccines. In this study, we investigated the possibility of detecting recombination events in TBEV by simulating recombinations at several locations on the virus' phylogenetic tree and for different lengths of recombining fragments...
2016: PloS One
https://www.readbyqxmd.com/read/27717318/recombinant-domains-iii-of-tick-borne-encephalitis-virus-envelope-protein-in-combination-with-dextran-and-cpgs-induce-immune-response-and-partial-protectiveness-against-tbe-virus-infection-in-mice
#12
Anna S Ershova, Olga A Gra, Alexander M Lyaschuk, Tatyana M Grunina, Artem P Tkachuk, Mikhail S Bartov, Darya M Savina, Olga V Sergienko, Zoya M Galushkina, Vladimir P Gudov, Liubov I Kozlovskaya, Ivan S Kholodilov, Larissa V Gmyl, Galina G Karganova, Vladimir G Lunin, Anna S Karyagina, Alexander L Gintsburg
BACKGROUND: E protein of tick-borne encephalitis virus (TBEV) and other flaviviruses is located on the surface of the viral particle. Domain III of this protein seems to be a promising component of subunit vaccines for prophylaxis of TBE and kits for diagnostics of TBEV. METHODS: Three variants of recombinant TBEV E protein domain III of European, Siberian and Far Eastern subtypes fused with dextran-binding domain of Leuconostoc citreum KM20 were expressed in E...
October 7, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27642148/-tick-borne-encephalitis-in-a-child-in-a-nonendemic-country-a-case-report
#13
M Levy, M-T Abi-Warde, A-C Rameau, S Fafi-Kremer, Y Hansmann, M Fischbach, L Higel
Tick-borne encephalitis (TBE) is an arbovirus induced by tick-borne encephalitis virus (TBEV) transmitted by tick bite. The disease is rare in France (two to three cases per year) but endemic zones extend from Western Europe to the east coast of Asia (10,000-15,000 cases per year). An 8-year-old boy was admitted to our pediatric ward in Strasbourg (France) for febrile headache with diplopia. Four days after a tick bite, he declared a febrile headache together with maculopapular rash on the elbows, knees, and cheeks...
October 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/27633257/a-serological-protein-microarray-for-detection-of-multiple-cross-reactive-flavivirus-infections-in-horses-for-veterinary-and-public-health-surveillance
#14
N B Cleton, K van Maanen, S A Bergervoet, N Bon, C Beck, G-J Godeke, S Lecollinet, R Bowen, D Lelli, N Nowotny, M P G Koopmans, C B E M Reusken
The genus Flavivirus in the family Flaviviridae includes some of the most important examples of emerging zoonotic arboviruses that are rapidly spreading across the globe. Japanese encephalitis virus (JEV), West Nile virus (WNV), St. Louis encephalitis virus (SLEV) and Usutu virus (USUV) are mosquito-borne members of the JEV serological group. Although most infections in humans are asymptomatic or present with mild flu-like symptoms, clinical manifestations of JEV, WNV, SLEV, USUV and tick-borne encephalitis virus (TBEV) can include severe neurological disease and death...
September 15, 2016: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/27576490/tick-borne-encephalitis-virus-induces-chemokine-rantes-expression-via-activation-of-irf-3-pathway
#15
Xiaowei Zhang, Zhenhua Zheng, Xijuan Liu, Bo Shu, Panyong Mao, Bingke Bai, Qinxue Hu, Minhua Luo, Xiaohe Ma, Zongqiang Cui, Hanzhong Wang
BACKGROUND: Tick-borne encephalitis virus (TBEV) is one of the most important flaviviruses that targets the central nervous system (CNS) and causes encephalitides in humans. Although neuroinflammatory mechanisms may contribute to brain tissue destruction, the induction pathways and potential roles of specific chemokines in TBEV-mediated neurological disease are poorly understood. METHODS: BALB/c mice were intracerebrally injected with TBEV, followed by evaluation of chemokine and cytokine profiles using protein array analysis...
2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27562931/first-human-case-of-tick-borne-encephalitis-virus-infection-acquired-in-the-netherlands-july-2016
#16
Joris A de Graaf, Johan H J Reimerink, G Paul Voorn, Elisabeth A Bij de Vaate, Ankje de Vries, Barry Rockx, Alie Schuitemaker, Vishal Hira
In July 2016, the first autochthonous case of tick-borne encephalitis was diagnosed in the Netherlands, five days after a report that tick-borne encephalitis virus (TBEV) had been found in Dutch ticks. A person in their 60s without recent travel history suffered from neurological symptoms after a tick bite. TBEV serology was positive and the tick was positive in TBEV qRT-PCR. TBEV infection should be considered in patients with compatible symptoms in the Netherlands.
August 18, 2016: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/27548676/utilisation-of-isa-reverse-genetics-and-large-scale-random-codon-re-encoding-to-produce-attenuated-strains-of-tick-borne-encephalitis-virus-within-days
#17
Lauriane de Fabritus, Antoine Nougairède, Fabien Aubry, Ernest A Gould, Xavier de Lamballerie
Large-scale codon re-encoding is a new method of attenuating RNA viruses. However, the use of infectious clones to generate attenuated viruses has inherent technical problems. We previously developed a bacterium-free reverse genetics protocol, designated ISA, and now combined it with large-scale random codon-re-encoding method to produce attenuated tick-borne encephalitis virus (TBEV), a pathogenic flavivirus which causes febrile illness and encephalitis in humans. We produced wild-type (WT) and two re-encoded TBEVs, containing 273 or 273+284 synonymous mutations in the NS5 and NS5+NS3 coding regions respectively...
2016: PloS One
https://www.readbyqxmd.com/read/27543616/nk-cell-responses-to-human-tick-borne-encephalitis-virus-infection
#18
Kim Blom, Monika Braun, Jolita Pakalniene, Sebastian Lunemann, Monika Enqvist, Laura Dailidyte, Marie Schaffer, Lars Lindquist, Aukse Mickiene, Jakob Michaëlsson, Hans-Gustaf Ljunggren, Sara Gredmark-Russ
Tick-borne encephalitis virus (TBEV) is a flavivirus that is transferred to humans by infected ticks. The virus causes tick-borne encephalitis, a severe infection of the CNS with a high risk for long-lasting sequelae. Currently, no treatment exists for the disease. Understanding the cellular immune response to this infection is important to gain further understanding into the pathogenesis, treatment, and prevention of the disease. NK cells are known to participate in the control of viral infections. We performed a longitudinal analysis of the human NK cell response to TBEV infection in a cohort of infected individuals from the onset of severe clinical symptoms to the convalescence phase...
October 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27527383/seroprevalence-of-tick-borne-encephalitis-virus-in-wild-game-in-mecklenburg-western-pomerania-north-eastern-germany
#19
Silvius Frimmel, Matthias Leister, Micha Löbermann, Frerk Feldhusen, Matthias Seelmann, Jochen Süss, Emil Christian Reisinger
Mecklenburg-Western Pomerania, a federal state in the north east of Germany, has never been a risk area for TBEV infection, but a few autochthonous cases, along with TBEV-RNA detection in ticks, have shown a low level of activity in natural foci of the virus in the past. As wild game and domestic animals have been shown to be useful sentinels for TBEV we examined sera from wild game shot in Mecklenburg-Western Pomerania for the prevalence of TBEV antibodies. A total of 359 sera from wild game were investigated...
October 2016: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/27478072/baltic-lineage-of-tick-borne-encephalitis-virus-a-putative-evolutionary-pathway
#20
S Y Kovalev, T A Mukhacheva
Tick-borne encephalitis virus (TBEV) is transmitted by ixodid ticks and has three subtypes. The most genetically heterogeneous and widely distributed is the Siberian subtype which is subdivided into two main phylogenetic lineages, Asian (TBEV-Sib(Asia)) and Baltic (TBEV-Sib(Baltic)). According to the hypothesis of quantum evolution of TBEV (Kovalev et al., 2014b), TBEV-Sib(Asia) originated about 370 years ago in Siberia, but the question concerning the time and place of origin of TBEV-Sib(Baltic) is still to be solved...
October 2016: Ticks and Tick-borne Diseases
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