keyword
MENU ▼
Read by QxMD icon Read
search

unloading

keyword
https://www.readbyqxmd.com/read/28550176/mechanical-behavior-and-matrisome-gene-expression-in-aneurysm-prone-thoracic-aorta-of-newborn-lysyl-oxidase-knockout-mice
#1
Marius Catalin Staiculescu, Jungsil Kim, Robert P Mecham, Jessica Wagenseil
Mutations in lysyl oxidase (LOX) are associated with thoracic aortic aneurysm and dissection (TAAD). Mice that do not express Lox (Lox(-/-)) die soon after birth and have 60% and 40% reductions in elastin- and collagen-specific crosslinks, respectively. LOX inactivation could also change the expression of secreted factors, structural matrix, and matrix-associated proteins that constitute the aortic matrisome. We hypothesize that the absence of Lox will change the mechanical behavior of the aortic wall due to reduced elastin and collagen crosslinking and alter the expression levels of matrisome and smooth muscle cell (SMC) genes in a vascular location-specific manner...
May 26, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28548824/improved-mechanistic-understanding-of-natural-gas-methane-emissions-from-spatially-resolved-aircraft-measurements
#2
Stefan Schwietzke, Gabrielle Petron, Stephen A Conley, Cody Pickering, Ingrid Mielke-Maday, Edward J Dlugokencky, Pieter P Tans, Tim Vaughn, Clay S Bell, Daniel Zimmerle, Sonja Wolter, Clark King, Allen B White, Timothy Coleman, Laura Bianco, Russell Schnell
Divergence in recent oil and gas related methane emission estimates between aircraft studies (basin total for a midday window) and emissions inventories (annualized regional and national statistics) indicate the need for better understanding the experimental design, including temporal and spatial alignment and interpretation of results. Our aircraft based methane emission estimates in a major US shale gas basin resolved from West to East show (i) similar spatial distributions for two days, (ii) strong spatial correlations with reported NG production (R(2)=0...
May 26, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28548693/hemodynamic-impact-of-the-c-pulse-cardiac-support-device-a-one-dimensional-arterial-model-study
#3
Daimé Campos Arias, Francisco Londono, Tania Rodríguez Moliner, Dimitrios Georgakopoulos, Nikos Stergiopulos, Patrick Segers
The C-Pulse is a novel extra-aortic counter-pulsation device to unload the heart in patients with heart failure. Its impact on overall hemodynamics, however, is not fully understood. In this study, the function of the C-Pulse heart assist system is implemented in a one-dimensional (1-D) model of the arterial tree, and central and peripheral pressure and flow waveforms with the C-Pulse turned on and off were simulated. The results were studied using wave intensity analysis and compared with in vivo data measured non-invasively in three patients with heart failure and with invasive data measured in a large animal (pig)...
May 26, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28542454/controlled-delivery-of-tauroursodeoxycholic-acid-from-biodegradable-microspheres-slows-retinal-degeneration-and-vision-loss-in-p23h-rats
#4
Laura Fernández-Sánchez, Irene Bravo-Osuna, Pedro Lax, Alicia Arranz-Romera, Victoria Maneu, Sergio Esteban-Pérez, Isabel Pinilla, María Del Mar Puebla-González, Rocío Herrero-Vanrell, Nicolás Cuenca
Successful drug therapies for treating ocular diseases require effective concentrations of neuroprotective compounds maintained over time at the site of action. The purpose of this work was to assess the efficacy of intravitreal controlled delivery of tauroursodeoxycholic acid (TUDCA) encapsulated in poly(D,L-lactic-co-glycolic acid) (PLGA) microspheres for the treatment of the retina in a rat model of retinitis pigmentosa. PLGA microspheres (MSs) containing TUDCA were produced by the O/W emulsion-solvent evaporation technique...
2017: PloS One
https://www.readbyqxmd.com/read/28536892/patient-specific-stress-analyses-in-the-ascending-thoracic-aorta-using-a-finite-element-implementation-of-the-constrained-mixture-theory
#5
S Jamaleddin Mousavi, Stéphane Avril
It is now a rather common approach to perform patient-specific stress analyses of arterial walls using finite-element models reconstructed from gated medical images. However, this requires to compute for every Gauss point the deformation gradient between the current configuration and a stress-free reference configuration. It is technically difficult to define such a reference configuration, and there is actually no guarantee that a stress-free configuration is physically attainable due to the presence of internal stresses in unloaded soft tissues...
May 23, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28535395/a-zinc-chloride-doped-adhesive-facilitates-sealing-at-the-dentin-interface-a-confocal-laser-microscopy-study
#6
Manuel Toledano, Raquel Osorio, Estrella Osorio, Inmaculada Cabello, Manuel Toledano-Osorio, Fátima S Aguilera
The aim of this study was to ascertain the effect of Zn-doping of dental adhesives and mechanical load cycling on the micromorphology of the resin-dentin interdiffusion zone (of sound and caries affected dentin). The investigation considered two different Zn-doped adhesive approaches and evaluated the interface using a doubled dye fluorescent technique and a calcium chelator fluorophore under a confocal laser scanning microscopy. Sound and carious dentin-resin interfaces of unloaded specimens were deficiently resin-hybridized, in general...
May 19, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28534200/atrophy-of-calf-muscles-by-unloading-results-in-an-increase-of-tissue-sodium-concentration-and-fat-fraction-decrease-a-23-na-mri-physiology-study
#7
D A Gerlach, K Schopen, P Linz, B Johannes, J Titze, J Zange, J Rittweger
PURPOSE: (23)Na MRI demonstrated increased tissue sodium concentrations in a number of pathologies. Acute atrophy results in muscle fibre volume shrinking that may result in a relative increase of extracellular volume and might affect sodium concentration. Thus, we hypothesized that local unloading of the calf muscles would lead to a decrease in muscle volume and an increase in muscle tissue sodium concentration. METHOD: One lower leg of 12 healthy male subjects was submitted to a 60 day long period of unloading using the Hephaistos orthosis, while the other leg served as control...
May 22, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28532968/off-loading-wheelchair-cushion-provides-best-case-reduction-in-tissue-deformation-as-indicated-by-mri
#8
Evan Call, Thomas Hetzel, Chad McLean, Joshua N Burton, Craig Oberg
Off-loading or the Orthotic approach to wheelchair seating has been used successfully to provide seating that optimizes tissue protection at the ischial tuberosities (ITs), sacrum and greater trochanters. Recent publications indicate the significance of preventing tissue compression to reduce ulcer formation. Comparative Magnetic Resonance Imaging (MRI) of individuals seated on two cushion types provides direct evidence of tissue unloading resulting in the reduction in tissue compression. Measurement of tissue compression in MRI images provides the cumulative impact of compression and shear resulting in ultimate tissue thickness documented here...
May 18, 2017: Journal of Tissue Viability
https://www.readbyqxmd.com/read/28532887/the-influence-of-walking-aids-on-the-plasticity-of-spinal-interneuronal-networks-central-pattern-generators-and-the-recovery-of-gait-post-stroke-a-literature-review-and-scholarly-discussion
#9
REVIEW
Clare C Maguire, Judith M Sieben, Robert A de Bie
BACKGROUND: Many aspects of post-stroke gait-rehabilitation are based on low-level evidence or expert opinion. Neuroscientific principles are often not considered when evaluating the impact of interventions. The use of walking-aids including canes and rollators, although widely used for long periods, has primarily been investigated to assess the immediate kinetic, kinematic or physiological effects. The long-term impact on neural structures und functions remains unclear. METHODS: A literature review of the function of and factors affecting plasticity of spinal interneuronal-networks and central-pattern-generators (CPG) in healthy and post-stroke patients...
April 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28529490/microgravity-induced-transcriptome-adaptation-in-mouse-paraspinal-longissimus-dorsi-muscle-highlights-insulin-resistance-linked-genes
#10
Guido Gambara, Michele Salanova, Stefano Ciciliot, Sandra Furlan, Martina Gutsmann, Gudrun Schiffl, Ute Ungethuem, Pompeo Volpe, Hanns-Christian Gunga, Dieter Blottner
Microgravity as well as chronic muscle disuse are two causes of low back pain originated at least in part from paraspinal muscle deconditioning. At present no study investigated the complexity of the molecular changes in human or mouse paraspinal muscles exposed to microgravity. The aim of this study was to evaluate longissimus dorsi adaptation to microgravity at both morphological and global gene expression level. C57BL/N6 male mice were flown aboard the BION-M1 biosatellite for 30 days (BF) or housed in a replicate flight habitat on ground (BG)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28528872/computational-study-to-investigate-effect-of-tonometer-geometry-and-patient-specific-variability-on-radial-artery-tonometry
#11
Pranjal Singh, Mohammed Ikbal Choudhury, Sitikantha Roy, Anamika Prasad
Tonometry-based devices are valuable method for vascular function assessment and for measurement of blood pressure. However current design and calibration methods rely on simple models, neglecting key geometrical features, and anthropometric and property variability among patients. Understanding impact of these influences on tonometer measurement is thus essential for improving outcomes of current devices, and for proposing improved design. Towards this goal, we present a realistic computational model for tissue-device interaction using complete wrist section with hyperelastic material and frictional contact...
May 5, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28527962/resolution-of-mitral-regurgitation-with-left-ventricular-assist-device-support
#12
Matthew Goodwin, Hassan W Nemeh, Jamil Borgi, Gaetano Paone, Jeffrey A Morgan
BACKGROUND: Cardiac valve disease is common in patients with end-stage heart failure undergoing left ventricular assist device implantation (LVAD). The aim of this study was to determine if preoperative mitral regurgitation (MR) affects outcomes and hemodynamics in patients after LVAD implantation. METHODS: From March 2006 through May 2015, 238 consecutive patients underwent LVAD implantation. Patient cohorts included less than moderate to severe MR (< moderate-severe, n = 195) and greater than or equal to moderate to severe MR (≥ moderate-severe, n = 43)...
May 17, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28522819/elastocaloric-effect-and-superelastic-stability-in-ni-mn-in-co-polycrystalline-heusler-alloys-hysteresis-and-strain-rate-effects
#13
Binfeng Lu, Jian Liu
Controlling material hysteresis and working frequency variability are fundamentally important for refrigeration cycle efficiency and power density in solid-state cooling systems. For elastocaloric cooling, understanding the relationship between the width of the stress hysteresis and elastocaloric behaviour during superelastic cycles under varied strain rates is important. In this work, we report the effects of strain rate effects on the superelastic and elastocaloric responses in Ni45Mn50-xInxCo5 (x = 13...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28521803/physical-interface-dynamics-alter-how-robotic-exosuits-augment-human-movement-implications-for-optimizing-wearable-assistive-devices
#14
Matthew B Yandell, Brendan T Quinlivan, Dmitry Popov, Conor Walsh, Karl E Zelik
BACKGROUND: Wearable assistive devices have demonstrated the potential to improve mobility outcomes for individuals with disabilities, and to augment healthy human performance; however, these benefits depend on how effectively power is transmitted from the device to the human user. Quantifying and understanding this power transmission is challenging due to complex human-device interface dynamics that occur as biological tissues and physical interface materials deform and displace under load, absorbing and returning power...
May 18, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28518000/comparison-of-simulated-microgravity-and-hydrostatic-pressure-for-chondrogenesis-of-hasc
#15
Liliana F Mellor, Andrew J Steward, Rachel C Nordberg, Michael A Taylor, Elizabeth G Loboa
BACKGROUND: Cartilage tissue engineering is a growing field due to the lack of regenerative capacity of native tissue. The use of bioreactors for cartilage tissue engineering is common, but the results are controversial. Some studies suggest that microgravity bioreactors are ideal for chondrogenesis, while others show that mimicking hydrostatic pressure is crucial for cartilage formation. A parallel study comparing the effects of loading and unloading on chondrogenesis has not been performed...
April 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28515468/cardiolipin-content-linoleic-acid-composition-and-tafazzin-expression-in-response-to-skeletal-muscle-overload-and-unload-stimuli
#16
Val A Fajardo, John S Mikhaeil, Cameron F Leveille, Caitlin Saint, Paul J LeBlanc
Cardiolipin (CL) is a unique mitochondrial phospholipid that, in skeletal muscle, is enriched with linoleic acid (18:2n6). Together, CL content and CL 18:2n6 composition are critical determinants of mitochondrial function. Skeletal muscle is comprised of slow and fast fibers that have high and low mitochondrial content, respectively. In response to overloading and unloading stimuli, these muscles undergo a fast-to-slow oxidative fiber type shift and a slow-to-fast glycolytic fiber type shift, respectively, with a concomitant change in mitochondrial content...
May 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28506101/evaluation-of-personal-inhalable-aerosol-samplers-with-different-filters-for-use-during-anthrax-responses
#17
Sergey A Grinshpun, Angela M Weber, Michael Yermakov, Reshmi Indugula, Yousef Elmashae, Tiina Reponen, Laura Rose
Risk of inhalation exposure to viable Bacillus anthracis (B. anthracis) spores has primarily been assessed using short-term, stationary sampling methods which may not accurately characterize the concentration of inhalable-sized spores reaching a person's breathing zone. While a variety of aerosol sampling methods have been utilized during previous anthrax responses, no consensus has yet been established for personal air sampling. The goal of this study was to determine the best sampler-filter combination(s) for the collection and extraction of B...
May 16, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/28501920/a-dramatic-blood-plasticity-in-hibernating-and-14-day-hindlimb-unloading-daurian-ground-squirrels-spermophilus-dauricus
#18
Huan-Xin Hu, Fang-Ying Du, Wei-Wei Fu, Shan-Feng Jiang, Jin Cao, Shen-Hui Xu, Hui-Ping Wang, Hui Chang, Nandu Goswami, Yun-Fang Gao
We compared the effects of hibernation inactivity and 14-day hindlimb unloading in non-hibernating period on biochemical, rheological, and hematological parameters of blood in Daurian ground squirrels (Spermophilus dauricus). Twenty-four squirrels were randomly divided into four groups: control (CON), hibernation (HIB), post-hibernation (POST), and 14-day hindlimb unloading (HU). The results showed that serum enzymes (L-lactate dehydrogenase, alanine aminotransferase, and aspartate aminotransferase) activities decreased in HIB, POST, and HU squirrels compared with CON...
May 13, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/28501374/the-effect-of-the-superior-cavopulmonary-anastomosis-on-ventricular-remodeling-in-infants-with-single-ventricle
#19
Renee Margossian, Victor Zak, Amanda J Shillingford, Anthony M Hlavacek, James F Cnota, Michael D Puchalski, Jami C Levine, Brian W McCrindle, Meryl S Cohen, Karen Altmann, Piers C Barker, Daphne T Hsu, Steven D Colan
BACKGROUND: Infants with single ventricular physiology have volume and pressure overload that adversely affect ventricular mechanics. The impact of superior cavopulmonary anastomosis (SCPA) on single left ventricles versus single right ventricles is not known. METHODS: As part of the Pediatric Heart Network placebo-controlled trial of enalapril in infants with single ventricular physiology, echocardiograms were obtained before SCPA and at 14 months and analyzed in a core laboratory...
May 10, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28497127/evidence-of-glycolysis-up-regulation-and-pyruvate-mitochondrial-oxidation-mismatch-during-mechanical-unloading-of-the-failing-human-heart-implications-for-cardiac-reloading-and-conditioning
#20
Nikolaos A Diakos, Sutip Navankasattusas, E Dale Abel, Jared Rutter, Lauren McCreath, Peter Ferrin, Stephen H McKellar, Dylan V Miller, Song Y Park, Russell S Richardson, Ralph Deberardinis, James E Cox, Abdallah G Kfoury, Craig H Selzman, Josef Stehlik, James C Fang, Dean Y Li, Stavros G Drakos
This study sought to investigate the effects of mechanical unloading on myocardial energetics and the metabolic perturbation of heart failure (HF) in an effort to identify potential new therapeutic targets that could enhance the unloading-induced cardiac recovery. The authors prospectively examined paired human myocardial tissue procured from 31 advanced HF patients at left ventricular assist device (LVAD) implant and at heart transplant plus tissue from 11 normal donors. They identified increased post-LVAD glycolytic metabolites without a coordinate increase in early, tricarboxylic acid (TCA) cycle intermediates...
October 2016: JACC. Basic to Translational Science
keyword
keyword
43267
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"