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https://www.readbyqxmd.com/read/28447380/lncrna-h19-modulates-wnt-%C3%AE-catenin-signaling-by-targeting-dkk4-in-hindlimb-unloaded-rat
#1
Bing Li, Jun Liu, Jie Zhao, Jian-Xiong Ma, Hao-Bo Jia, Yang Zhang, Guo-Sheng Xing, Xin-Long Ma
OBJECTIVE: To investigate the biological functions of long noncoding RNA-H19 (H19) in the pathogenesis of disuse osteoporosis (DOP). METHODS: Fifty-four male Sprague Dawley (SD) rats were randomly divided into three groups: baseline control (BC, 6), age-matched control (AC, 24), and hindlimb unloading (HLU, 24). The rats in the BC group were sacrificed at the beginning of the experiment, while the AC and HLU rats were sacrificed at different times (7, 14, 21 and 28 days after HLU)...
April 26, 2017: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28446637/drought-enhanced-xylem-sap-sulfate-closes-stomata-by-affecting-almt12-and-guard-cell-aba-synthesis
#2
Frosina Malcheska, Altaf Ahmad, Sundas Batool, Heike M Müller, Jutta Ludwig-Müller, Juergen Kreuzwieser, Dörte Randewig, Robert Hänsch, Ralf R Mendel, Ruediger Hell, Markus Wirtz, Dietmar Geiger, Peter Ache, Rainer Hedrich, Cornelia Herschbach, Heinz Rennenberg
Water limitation of plants causes stomatal closure to prevent water loss by transpiration. For this purpose, progressing soil water deficit is communicated from roots to shoots. Abscisic acid (ABA) is the key signal in stress-induced stomatal closure, however, ABA as early xylem-delivered signal is still a matter of debate. In the present study, poplar plants were exposed to water stress to investigate xylem sap sulfate and ABA, stomatal conductance and sulfate transporter (SULTR) expression. In addition, stomatal behavior and expression of ABA receptors, drought responsive genes, transcription factors and NCED3 were studied after feeding sulfate and ABA to detached poplar leaves and epidermal peels of Arabidopsis...
April 26, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28442147/troubleshooter-in-electrical-storm-mechanical-unloading-leads-to-heart-rhythm-stabilization
#3
Johannes Mierke, Tobias Loehn, Christian Pfluecke, Karim Ibrahim
The electrical storm is a life-threatening situation which causes a complex antiarrhythmic treatment. We firstly report a rhythmological stabilization through mechanical unloading of the left ventricle in a health patient who developed electrical storm after endo- and epicardiac re-ablation and who previously underwent 27 unsuccessful defibrillations. No evidence for a specific etiology of the rhythm disturbances was found. After implantation of a percutaneous left ventricular assist device (pLVAD) a single additional defibrillation was needed to terminate ventricular fibrillation...
April 18, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28437495/a-practical-guide-to-understanding-and-treating-patellofemoral-pain
#4
John P Fulkerson
There is no shortcut to accurate diagnosis in the patellofemoral pain patient. Most important in the process is a desire and ability to specifically identify the structural and biomechanical origin of pain. This can be elusive and often requires a careful analysis of all factors affecting the patient, including documenting his or her specific history of pain origin and specific treatments to date, and acknowledging the patient's localization of the pain origin. Many patients can pinpoint the site of pain origin when given the time and encouragement to do so...
March 2017: American Journal of Orthopedics
https://www.readbyqxmd.com/read/28432957/nanoencapsulation-strategies-for-the-delivery-of-novel-bifunctional-antioxidant-%C3%AF-1-selective-ligands
#5
Claudia Carbone, Emanuela Arena, Veronica Pepe, Orazio Prezzavento, Ivana Cacciatore, Hasan Turkez, Agostino Marrazzo, Antonio Di Stefano, Giovanni Puglisi
Nowadays sigma-1 receptors are considered as new therapeutic objectives for central nervous system neurodegenerative diseases. Among different molecules, alpha lipoic acid has been identified as a natural potent antioxidant drug, whose therapeutic efficacy is limited by its many drawbacks, such as fast metabolism, poor bioavailability and high physico-chemical instability. Alfa-lipoic acid derivatives have been recently developed demonstrating their neuroprotective activity and effectiveness in different types of oxidative stress...
April 12, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28431799/an-mri-investigation-of-the-effects-of-user-anatomy-and-wheelchair-cushion-type-on-tissue-deformation
#6
David Brienza, Jaxon Vallely, Patricia Karg, Jonathan Akins, Amit Gefen
AIM OF THE STUDY: Tissue deformation is recognized as an important risk factor for pressure injuries. This study investigated the effects of anatomy and wheelchair cushion type on tissue deformation. MATERIALS AND METHODS: Direct 3-dimensional tissue deformation response was measured for six participants sitting on six different wheelchair cushions using MR imaging. Two participants had a traumatic spinal cord injury (SCI) within one year of the assessment, two sustained traumatic SCI at least 13 years prior, and two were without SCI...
April 11, 2017: Journal of Tissue Viability
https://www.readbyqxmd.com/read/28426383/contribution-of-sucrose-transporters-to-phloem-unloading-within-sorghum-bicolor-stem-internodes
#7
Ricky J Milne, Anke Reinders, John M Ward, Christina E Offler, John W Patrick, Christopher P L Grof
Sucrose produced in source leaves is loaded into collection phloem, transported to sinks and unloaded for utilisation or storage. In the context of long distance transport, sucrose transporters (SUTs) can function to load sucrose into collection phloem, retrieve leaked sucrose during long distance transport, and load sucrose into sink cells. SUTs have also been proposed to efflux sucrose under conditions of low proton motive force and low extracellular sucrose. The involvement of sucrose transporters in phloem unloading in a representative monocot stem, Sorghum bicolor, was evaluated during different stages of internode development...
April 20, 2017: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/28423017/auxotonic-to-isometric-contraction-transitioning-in-a-beating-heart-causes-myosin-step-size-to-down-shift
#8
Thomas P Burghardt, Xiaojing Sun, Yihua Wang, Katalin Ajtai
Myosin motors in cardiac ventriculum convert ATP free energy to the work of moving blood volume under pressure. The actin bound motor cyclically rotates its lever-arm/light-chain complex linking motor generated torque to the myosin filament backbone and translating actin against resisting force. Previous research showed that the unloaded in vitro motor is described with high precision by single molecule mechanical characteristics including unitary step-sizes of approximately 3, 5, and 8 nm and their relative step-frequencies of approximately 13, 50, and 37%...
2017: PloS One
https://www.readbyqxmd.com/read/28422571/reliability-of-measuring-lower-limb-muscle-emg-activity-ratio-in-activities-of-daily-living-with-electrodes-embedded-in-the-clothing
#9
Dagny Bengs, Ira Jeglinsky, Jukka Surakka, Thomas Hellsten, Joachim Ring, Jyrki Kettunen
CONTEXT: Using technical clothes with electrodes embedded in the clothing makes it possible to record the electrical activity produced by the activity of the skeletal muscles in activities of daily living. OBJECTIVE: The aim of the study was to investigate the reliability of measuring lower-limb left-right electromyography (EMG) activity ratio with smart shorts during stair descent, stair ascent, and repeated unloaded squats among healthy working-aged subjects. METHODS: Seventeen females (mean age 25...
April 19, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28421400/a-multistage-dialysis-microdevice-for-extraction-of-cryoprotectants
#10
Lili Zou, Shibo Li, Yufeng Kang, Juanjuan Liu, Liqun He, Sijie Sun, Dayong Gao, Bensheng Qiu, Weiping Ding
In this study, we present a multistage-dialysis microdevice (MDM) for extraction of cryoprotectants (CPAs) from a CPA-laden cell suspension. We confirmed the functions of the key designs of the MDM using a fluorescence solution, we assessed the performance of the MDM by using the MDM to unload glycerin from glycerin-loaded swine erythrocytes, and we investigated the effects of the cell suspension flow rate, glycerin concentration, cell density, and membrane pore size on the clearance efficiency of glycerin (CG), the survival rate of cells (SC), and the recovery rate of cells (RC)...
June 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28420761/in-situ-measurements-of-tensile-forces-in-the-tibialis-anterior-tendon-of-the-rat-in-concentric-isometric-and-resisted-co-contractions
#11
Martin Schmoll, Ewald Unger, Hazel Sutherland, Michael Haller, Manfred Bijak, Hermann Lanmüller, Jonathan C Jarvis
Tensile-force transmitted by the tibialis anterior (TA) tendon of 11 anesthetized adult male Wistar rats (body-mass: 360.6 ± 66.3 g) was measured in-situ within the intact biomechanical system of the hind-limb using a novel miniature in-line load-cell. The aim was to demonstrate the dependence of the loading-profile experienced by the muscle, on stimulation-frequency and the resistance to shortening in a group of control-animals. Data from these acute-experiments shows the type of loading achievable by means of implantable electrical stimulators activating agonists or agonist/antagonist groups of muscles during programmed resistance-training in freely moving healthy subjects...
April 2017: Physiological Reports
https://www.readbyqxmd.com/read/28419698/collagen-barrier-membranes-do-not-adsorb-hypoxia-mimetic-activity-activity-of-gingival-fibroblasts-cultured-directly-on-collagen-barrier-membranes-loaded-with-hypoxia-mimetic-agents
#12
Diana Al-Habbal, Klara Janjić, Michael Edelmayer, Andreas Moritz, Hermann Agis
Hypoxia-based strategies for applications in oral surgery and periodontology have been proposed where collagen barrier membranes (CBM) are loaded with hypoxia mimetic agents (HMA) to induce a pro-angiogenic response. While it was found that CBM release HMA, it remained unclear if CBM adsorb HMA activity. Here we evaluated the response of oral cells cultured on CBM, supplemented with the HMA dimethyloxalylglycine (DMOG), desferrioxamine (DFO), and l-mimosine (l-MIM). Gingival fibroblasts (GF) were cultured on unwashed CBM as well as on CBM that had been washed with serum-free medium for 48 hours...
April 18, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28417560/treatment-of-tumor-in-lymph-nodes-using-near-infrared-laser-light-activated-thermosensitive-liposome-encapsulated-doxorubicin-and-gold-nanorods
#13
Daisuke Matsuki, Oladipo Adewale, Sachiko Horie, Junnosuke Okajima, Atsuki Komiya, Oluwatobi Oluwafemi, Shigenao Maruyama, Shiro Mori, Tetsuya Kodama
Tumor metastasis to lymph nodes is an important contributory factor for cancer-related deaths despite recent developments in cancer therapy. In this study, we demonstrate that tumor in the proper axillary lymph node (PALN) of the mouse can be treated by the application of external laser light to trigger the unloading of doxorubicin (DOX) encapsulated in thermosensitive liposomes (TSLs) administered together with gold nanorods (GNRs). GNRs + DOX-TSLs were injected into a mouse lymph node containing cancer cells (malignant fibrous histiocytoma-like cells) and intranodal DOX release was activated using near-infrared (NIR) laser irradiation...
April 18, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28416399/fabrication-of-semisynthetic-collagenic-materials-for-mere-synergistic-adsorption-a-model-approach-of-determining-dye-allocation-by-systematic-characterization-and-optimization
#14
Mrinmoy Karmakar, Manas Mahapatra, Arnab Dutta, Pijush Kanti Chattopadhyay, Nayan Ranjan Singha
Bovine collagen was functionalized by extensive process modifications for fabricating tanned bovine collagen fibers (TBCFs), as a new semisynthetic macro-, meso- and micro- porous adsorbent, of unprecedented physicochemical properties and excellent industrial waste removal efficiency. Mere or interactive effects were rationally understood, via analyzing monomer-dimer equilibrium, H-/J-aggregate formation, H-bonding, metachromasia, dye-dye complex formation etc., through extensive UV-vis analyses, during removal of acidic, like Acid Brown 369 (AB369), Acid Red 131 (AR131) and Acid Blue 113 (AB113) and basic, like Methylene Blue (MB) dyes...
April 14, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28416103/a-new-twist-on-right-heart-failure-with-left-ventricular-assist-systems
#15
EDITORIAL
Brian A Houston, Keyur B Shah, Mandeep R Mehra, Ryan J Tedford
Despite significant efforts to predict and prevent right heart failure, it remains a leading cause of morbidity and mortality after implantation of left ventricular assist systems (LVAS). In this Perspective, we review the underappreciated anatomic and physiologic principles that govern the relationship between left and right heart function and contribute to this phenomenon. This includes the importance of considering the right ventricle (RV) and pulmonary arterial circuit as a coupled system; the contribution of the left ventricle (LV) to RV contractile function and the potential negative impact of acutely unloading the LV; the influence of the pericardium and ventricular twist on septal function; the role of RV deformation in reduced mechanical efficiency after device placement; and the potential of ongoing stressors of an elevated right-sided preload...
March 24, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28415255/numerical-study-of-one-dimensional-compression-of-granular-materials-i-stress-strain-behavior-microstructure-and-irreversibility
#16
Mohamed Hassan Khalili, Jean-Noël Roux, Jean-Michel Pereira, Sébastien Brisard, Michel Bornert
The behavior of a model granular material, made of slightly polydisperse beads with Hertz-Mindlin elastic-frictional contacts, in oedometric compression (i.e., compression along one axis, with no lateral strain) is studied by grain-level numerical simulations. We systematically investigate the influence of the (idealized) packing process on the microstructure and stresses in the initial, weakly confined equilibrium state, and prepare both isotropic and anisotropic configurations differing in solid fraction Φ and coordination number z...
March 2017: Physical Review. E
https://www.readbyqxmd.com/read/28413579/metabolic-recovery-of-the-failing-heart-emerging-therapeutic-options
#17
Dale J Hamilton
Heart failure has mortality rates that parallel those of breast cancer. Current management strategies include neurohormonal blockade, rate control measures, natriuretic peptide preservation, implantation of mechanical assist devices, and heart transplantation. Despite these strategies, however, the failing myocardium remains energy depleted. New strategies to promote metabolic recovery are being developed to potentially augment current treatment guidelines. For example, an unexpected finding of our own studies showed that mechanical unloading with assist devices in advanced-stage heart failure restored metabolic flux...
January 2017: Methodist DeBakey Cardiovascular Journal
https://www.readbyqxmd.com/read/28412818/transparent-ethenylene-bridged-polymethylsiloxane-aerogels-mechanical-flexibility-and-strength-and-availability-for-addition-reaction
#18
Taiyo Shimizu, Kazuyoshi Kanamori, Ayaka Maeno, Hironori Kaji, Cara M Doherty, Kazuki Nakanishi
Transparent, low-density ethenylene-bridged polymethylsiloxane [Ethe-BPMS, O2/2(CH3)Si-CH═CH-Si(CH3)O2/2] aerogels from 1,2-bis(methyldiethoxysilyl)ethene have successfully been synthesized via a sol-gel process. A two-step sol-gel process composed of hydrolysis under acidic conditions and polycondensation under basic conditions in a liquid surfactant produces a homogeneous pore structure based on cross-linked nanosized colloidal particles. Visible-light transmittance of the aerogels varies with the concentration of the base catalyst and reaches as high as 87% (at a wavelength of 550 nm for a 10 mm thick sample)...
April 26, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28412437/3d-echocardiography-and-ventricular-unloading-with-continuous-flow-lvad-potential-advantages-to-optimize-patient-outcome
#19
EDITORIAL
Jerry D Estep
No abstract text is available yet for this article.
April 7, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28408023/on-the-road-to-full-cardiac-recovery-with%C3%A2-mechanical-unloading-are-we-there-yet
#20
EDITORIAL
Abdallah G Kfoury
No abstract text is available yet for this article.
April 18, 2017: Journal of the American College of Cardiology
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