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verapamil glucoprotein p

Qian Wu, Xiao-Dong Wen, Lian-Wen Qi, Wei Wang, Ling Yi, Zhi-Ming Bi, Ping Li
Harpagoside, a major bioactive iridoid glucoside in genus Scrophularia, has been widely used in clinical practice for the treatment of pain in the joints and lower back for its neuroprotective and anti-inflammation activities. To investigate the pharmacokinetics and hepatobiliary excretion, an in vivo microdialysis method coupled with high performance liquid chromatography was developed to monitor the concentration of harpagoside in blood and bile. The harpagoside bile-to-blood distribution ratio (AUC(bile)/AUC(blood)) up to 986...
March 15, 2009: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Lei Xia, Peng Shen
OBJECTIVE: To study the effects of Siwu Mixture on reversing the multidrug resistance (MDR) of human erythrocyte leukemic cell line K562/ADM. METHOD: With verapamil set as a positive control, MTT assay was applied to evaluate the resistant factor of cell line K562/ADM to anticancer drugs and the reversal index of Siwu Mixture on MDR of the cells. The concentration of adriamycin(ADM) in the cells was measured by reversal-phase high performance liquid chromatography...
August 2004: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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