keyword
https://read.qxmd.com/read/38466402/long-term-survival-and-functional-outcomes-of-critically-ill-patients-with-hematologic-malignancies-a-canadian-multicenter-prospective-study
#21
JOURNAL ARTICLE
Laveena Munshi, Guillaume Dumas, Bram Rochwerg, Farah Shoukat, Michael Detsky, Dean A Fergusson, Bruno L Ferreyro, Paul Heffernan, Margaret Herridge, Sheldon Magder, Mark Minden, Rakesh Patel, Salman Qureshi, Aaron Schimmer, Santhosh Thyagu, Han Ting Wang, Sangeeta Mehta
PURPOSE: Patients with hematologic malignancy (HM) commonly develop critical illness. Their long-term survival and functional outcomes have not been well described. METHODS: We conducted a prospective, observational study of HM patients admitted to seven Canadian intensive care units (ICUs) (2018-2020). We followed survivors at 7 days, 6 months and 12 months following ICU discharge. The primary outcome was 12-month survival. We evaluated functional outcomes at 6 and 12 months using the functional independent measure (FIM) and short form (SF)-36 as well as variables associated with 12-month survival...
March 11, 2024: Intensive Care Medicine
https://read.qxmd.com/read/38465637/vascular-reactivity-index-as-an-effective-predictor-of-mortality-in-patients-with-septic-shock-a-retrospective-study
#22
JOURNAL ARTICLE
Sun Jingyi, Gao Cunliang, Chen Biao, Xie Yingguang, Ma Jinluan, Cao Xiaohua, Li Wenqiang
BACKGROUND: Sepsis is a serious complication that occurs after trauma, burns, and infections, and it is an important cause of death in intensive care unit (ICU) patients. Despite many new measures being proposed for sepsis treatment, its mortality rate remains high; sepsis has become a serious threat to human health, and there is an urgent need to carry out in-depth clinical research related to sepsis. In recent years, it has been found that septic shock-induced vasoplegia is a result of vascular hyporesponsiveness to vasopressors...
March 11, 2024: Journal of Intensive Care Medicine
https://read.qxmd.com/read/38462876/procalcitonin-to-albumin-ratio-as-a-biomarker-for-predicting-mortality-in-sepsis
#23
JOURNAL ARTICLE
Adem Keskin, Recai Aci
OBJECTIVE: To investigate the ability of the procalcitonin to albumin ratio to predict mortality in patients with sepsis. STUDY DESIGN: Observational study. PLACE AND DURATION OF STUDY: Department of Intensive care, Samsun Training and Research Hospital, Samsun, Turkiye, from September to December 2022. METHODOLOGY: Patients diagnosed with sepsis admitted to the intensive care unit were included in the study. They were divided into two groups based on their prognosis (expiry/survival)...
March 2024: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://read.qxmd.com/read/38462861/outcomes-of-haematopoietic-stem-cell-transplantation-in-beta-thalassemia-major-with-fully-matched-parents-as-donor
#24
JOURNAL ARTICLE
Asghar Ali Kerio, Nighat Shahbaz, Tariq Azam Khattak, Tariq Ghafoor, Muhammad Farhan, Hashim Khan
OBJECTIVE: To determine the outcome of beta thalassemia major (BTM) patients undergoing haematopoietic stem cells (HSCT), with fully matched parents as donors vs. matched sibling donors (MSD). STUDY DESIGN: Observational Study. Place and Duration of the Study: Department of Clinical Haematology and Bone Marrow Transplantation Centre, Rawalpindi, Pakistan, from January 2013 to July 2023. METHODOLOGY: Group A consisted of BTM patients who underwent HSCT with fully matched siblings as donors, and Group B consisted of BTM patients who underwent HSCT with fully matched parents as donors...
March 2024: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://read.qxmd.com/read/38460770/polydispersity-mediated-high-efficacy-of-an-in-situ-aqueous-nanosuspension-of-ppef-3hcl-in-methicillin-resistant-staphylococcus-aureus-sepsis-model
#25
JOURNAL ARTICLE
Amit S Lokhande, Vikas Maurya, Komal Rani, Palak Parashar, Rajni Gaind, Vibha Tandon, Padma V Devarajan
Recently, World Health Organization declared antimicrobial resistance as the third greatest threat to human health. Absence of known cross-resistance, new class, new target, and a new mode of action are few major strategies being undertaken by researches to combat multidrug resistant pathogen. PPEF.3HCl, a bisbenzimidazole was developed as highly potent antibacterial agent against ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) pathogens, targeting topoisomerase IA...
March 7, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38459892/ybx-1-alleviates-sepsis-stimulated-lung-epithelial-cell-injury
#26
JOURNAL ARTICLE
Xin Lu, Shouqian Dai, Pengfei Li, Yuqian Zhou, Feng Xu
OBJECTIVE: To explore the role of Y-box binding protein 1 (YBX-1) in the lipopolysaccharide (LPS)-stimulated inflammation and oxidative stress of BEAS-2B cell line and clarify the underlying mechanism. METHODS: LPS-stimulated BEAS-2B cells were used as a cell model of sepsis-stimulated acute lung injury (ALI). Immunoblot and quantitative polymerase chain reaction assays were used to detect the expression of YBX-1 in LPS-stimulated BEAS-2B cells. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide, TdT-mediated dUTP nick end labeling, and immunoblot assays were conducted to determine the effects of YBX-1 on cell survival...
2024: Allergologia et Immunopathologia
https://read.qxmd.com/read/38459470/mortality-and-associated-factors-among-children-admitted-to-an-intensive-care-unit-in-muhimbili-national-hospital-from-the-time-of-admission-to-three-months-after-discharge-a-prospective-cohort-study
#27
JOURNAL ARTICLE
Rehema E Lyimo, Yasser H Said, Sokoine L Kivuyo, Deogratias Nkya, Francis F Furia
BACKGROUND: Mortality of children admitted to Intensive Care Units (ICU) is higher in low-to-middle-income countries (LMICs) as compared to high-income countries (HICs). There is paucity of information on outcomes following discharge from ICU, especially from sub-Saharan Africa region. This study was conducted to determine mortality and its associated factors among children admitted to Pediatric ICU (PICU) at Muhimbili National Hospital, from admission to three months after discharge...
March 8, 2024: BMC Pediatrics
https://read.qxmd.com/read/38459373/prophylactic-early-low-dose-hydrocortisone-and-survival-without-bronchopulmonary-dysplasia-among-extremely-preterm-infants-born-at-22-27-weeks-gestation
#28
JOURNAL ARTICLE
Sanket D Shah, Samarth Shukla, P Sireesha Nandula, Shannon Vice, Marwa Elgendy, Shiva Gautam, Mark L Hudak, Josef Cortez
OBJECTIVE: To compare survival without BPD among extremely preterm infants (EPI) who received prophylactic early low-dose hydrocortisone (PEH) with those who did not (non-PEH). STUDY DESIGN: This single-center retrospective study compared risk-adjusted rates of survival without BPD, BPD, bowel perforation, and late-onset sepsis among infants (22-27 weeks' gestation at birth) who received PEH (n = 82) and who did not (n = 205). RESULTS: Infants in the PEH group were of lower gestational age, lower birthweight, and higher day-1 risk of death/BPD...
March 8, 2024: Journal of Perinatology: Official Journal of the California Perinatal Association
https://read.qxmd.com/read/38458135/targeting-blood-brain-barrier-for-sepsis-associated-encephalopathy-regulation-of-immune-cells-and-ncrnas
#29
REVIEW
Mi Tian, Yunliang Zhan, Jinyuan Cao, Jinqi Gao, Jie Sun, Li Zhang
Sepsis causes significant morbidity and mortality worldwide, most surviving patients show acute or chronic mental disorders, which are known as sepsis-associated encephalopathy (SAE). SAE involves many pathological processes, including the blood-brain barrier (BBB) damage. The BBB is located at the interface between the central nervous system and the surrounding environment, which protects the central nervous system (CNS) from the invasion of exogenous molecules, harmful substances or microorganisms in the blood...
March 6, 2024: Brain Research Bulletin
https://read.qxmd.com/read/38457063/impact-of-age-on-the-host-response-to-sepsis-in-a-murine-model-of-fecal-induced-peritonitis
#30
JOURNAL ARTICLE
Neha Sharma, Alex Chen, Leah Heinen, Ruth Liu, Dhruva J Dwivedi, Ji Zhou, Manoj M Lalu, Asher A Mendelson, Braedon McDonald, Colin A Kretz, Alison E Fox-Robichaud, Patricia C Liaw
INTRODUCTION: Despite older adults being more vulnerable to sepsis, most preclinical research on sepsis has been conducted using young animals. This results in decreased scientific validity since age is an independent predictor of poor outcome. In this study, we explored the impact of aging on the host response to sepsis using the fecal-induced peritonitis (FIP) model developed by the National Preclinical Sepsis Platform (NPSP). METHODS: C57BL/6 mice (3 or 12 months old) were injected intraperitoneally with rat fecal slurry (0...
March 8, 2024: Intensive Care Medicine Experimental
https://read.qxmd.com/read/38456367/single-cell-sequencing-reveals-myof-enriched-monocyte-macrophage-subcluster-as-a-favorable-prognostic-factor-in-sepsis
#31
JOURNAL ARTICLE
Yi-Fan Zhang, Zhu-Jun Yi, Wen-Feng Zhang, Lian Yang, Feng Qi, Ting Yu, Zhu Zhu, Ming-Jie Li, Yao Cheng, Lei Zhao, Jian-Ping Gong, Pei-Zhi Li
This research utilized single-cell RNA sequencing to map the immune cell landscape in sepsis, revealing 28 distinct cell clusters and categorizing them into nine major types. Delving into the monocyte/macrophage subclusters, 12 unique subclusters are identified and pathway enrichment analyses are conducted using KEGG and GO, discovering enriched pathways such as oxidative phosphorylation and antigen processing. Further GSVA and AUCell assessments show varied activation of interferon pathways, especially in subclusters 4 and 11...
March 8, 2024: Advanced biology
https://read.qxmd.com/read/38452729/advances-in-molecular-agents-targeting-toll-like-receptor-4-signaling-pathways-for-potential-treatment-of-sepsis
#32
REVIEW
Yunyun Zheng, Yingying Gao, Weiru Zhu, Xian-Guang Bai, Jinxu Qi
Sepsis is a systemic inflammatory response syndrome caused by an infection. Toll-like receptor 4 (TLR4) is activated by endogenous molecules released by injured or necrotic tissues. Additionally, TLR4 is remarkably sensitive to infection of various bacteria and can rapidly stimulate host defense responses. The TLR4 signaling pathway plays an important role in sepsis by activating the inflammatory response. Accordingly, as part of efforts to improve the inflammatory response and survival rate of patients with sepsis, several drugs have been developed to regulate the inflammatory signaling pathways mediated by TLR4...
March 2, 2024: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/38452632/active-versus-restrictive-ligation-strategy-for-patent-ductus-arteriosus-a-retrospective-two-center-study-of-extremely-preterm-infants-born-between-22%C3%A2-%C3%A2-0-and-25%C3%A2-%C3%A2-6%C3%A2-weeks-of-gestational-age
#33
JOURNAL ARTICLE
Fanny Söderström, Richard Sindelar, Karl Wilhelm Olsson, Sawin Yousef, Daniela Todorova, Joanna Pestalozzi, Mats Mellander, Renske Raaijmakers
BACKGROUND: Patent ductus arteriosus (PDA) in premature infants is associated with adverse clinical outcomes. Mode and timing of treatment are still controversial. Data are limited in the most extremely premature infants <26 weeks of gestational age (GA), where clinical problems are most significant and patients are most vulnerable. AIMS: To investigate whether different approaches to surgical closure of PDA in two large Swedish centers has an impact on clinical outcomes including mortality in extremely preterm infants born <26 weeks GA...
February 29, 2024: Early Human Development
https://read.qxmd.com/read/38450378/prognostic-value-of-right-ventricular-free-wall-strain-in-patients-with-sepsis
#34
JOURNAL ARTICLE
Hongmin Chen, Lei Huang, Boyuan Xing, Yang Gao, Jie Zhang, Bingyi Zhang
BACKGROUND: Right ventricular systolic dysfunction (RVSD) in patients with sepsis is an area of growing interest, but its prognostic significance remains unclear and additional tools are needed to improve our understanding. Right ventricular free wall strain (RV-FWS) is a relatively new parameter to assess RV function. This study aimed to investigate the potential correlation between impaired RV-FWS and prognostic outcomes in patients with sepsis. METHODS: We prospectively assessed right ventricular function in patients with sepsis within the initial 24 h of their hospital admission...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38449666/novel-therapeutic-role-of-ganoderma-polysaccharides-in-a-septic-mouse-model-the-key-role-of-macrophages
#35
JOURNAL ARTICLE
Wei Xiong, Jing Xia, Xiaoyuan Peng, Ying Tan, Wansong Chen, Minghua Zhou, Ce Yang, Wenxiang Wang
Ganoderma lucidum polysaccharides (G. PS) have been recognized for their immune-modulating properties. In this study, we investigated the impact of G. PS in a sepsis mouse model, exploring its effects on survival, inflammatory cytokines, Treg cell differentiation, bacterial load, organ dysfunction, and related pathways. We also probed the role of macrophages through chlorphosphon-liposome pretreatment. Using the cecal ligation and puncture (CLP) model, we categorized mice into normal, PBS, and G. PS injection groups...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38449477/autologous-cryo-shocked-neutrophils-enable-targeted-therapy-of-sepsis-via-broad-spectrum-neutralization-of-pro-inflammatory-cytokines-and-endotoxins
#36
JOURNAL ARTICLE
Qiuxia Gao, Yan Yan, Jie Zhang, Xiaoxue Li, Jiamei Wang, Yi Feng, Peiran Li, Huanhuan Wang, Yunlong Zhang, Lingjie He, Zhiyan Shan, Bin Li
Background: Sepsis is a life-threatening disease characterized by multiple organ failure due to excessive activation of the inflammatory response and cytokine storm. Despite recent advances in the clinical use of anti-cytokine biologics, sepsis treatment efficacy and improvements in mortality remain unsatisfactory, largely due to the mechanistic complexity of immune regulation and cytokine interactions. Methods: In this study, a broad-spectrum anti-inflammatory and endotoxin neutralization strategy was developed based on autologous "cryo-shocked" neutrophils (CS-Neus) for the management of sepsis...
2024: Frontiers in Chemistry
https://read.qxmd.com/read/38449428/impact-of-a-coordinated-sepsis-response-on-time-to-treatment-in-a-pediatric-emergency-department
#37
JOURNAL ARTICLE
Jacqueline Corboy, Kimberly Denicolo, Roderick C Jones, Norma-Jean E Simon, Mark Adler, Jennifer Trainor, Rebecca Steinmann, Priya Jain, Rebecca Stephen, Elizabeth Alpern
BACKGROUND: Sepsis is responsible for 75 000 pediatric hospitalizations annually, with an associated mortality rate estimated between 11% and 19%. Evidence supports the use of timely fluid resuscitation and antibiotics to decrease morbidity and mortality. Our emergency department did not meet the timeliness goals for fluid and antibiotic administration suggested by the 2012 Surviving Sepsis Campaign. METHODS: In November 2018, we implemented a sepsis response team utilizing a scripted communication tool and a dedicated sepsis supply cart to address timeliness barriers...
March 7, 2024: Hospital Pediatrics
https://read.qxmd.com/read/38446306/intestinal-rehabilitation-program-for-adult-patients-with-intestinal-failure-a-20-year-analysis-of-outcomes-in-the-single-center-experience-at-a-tertiary-hospital
#38
JOURNAL ARTICLE
Kyoung Moo Im, Jae Hee Chung
BACKGROUND & AIMS: The intestinal rehabilitation program (IRP) is a specialized approach to managing patients with intestinal failure (IF). The goal of IRP is to reduce the patient's dependence on parenteral nutrition by optimizing nutrition intake while minimizing the risk of complications and providing individualized medical and surgical treatment. We aimed to provide a thorough overview of our extensive history in adult IRP. METHODS: We reviewed the medical records of adults with IF treated at our center's IRP over the past two decades...
March 6, 2024: Digestive Diseases and Sciences
https://read.qxmd.com/read/38445412/the-combination-of-kidney-function-variables-with-cell-cycle-arrest-biomarkers-identifies-distinct-subphenotypes-of-sepsis-associated-acute-kidney-injury-a-post-hoc-analysis-the-phenaki-study
#39
MULTICENTER STUDY
Dimitri Titeca-Beauport, Momar Diouf, Delphine Daubin, Ly Van Vong, Guillaume Belliard, Cédric Bruel, Yoann Zerbib, Christophe Vinsonneau, Kada Klouche, Julien Maizel
BACKGROUND: The severity and course of sepsis-associated acute kidney injury (SA-AKI) are correlated with the mortality rate. Early detection of SA-AKI subphenotypes might facilitate the rapid provision of individualized care. PATIENTS AND METHODS: In this post-hoc analysis of a multicenter prospective study, we combined conventional kidney function variables with serial measurements of urine (tissue inhibitor of metalloproteinase-2 [TIMP-2])* (insulin-like growth factor-binding protein [IGFBP7]) at 0, 6, 12, and 24 h) and then using an unsupervised hierarchical clustering of principal components (HCPC) approach to identify different phenotypes of SA-AKI...
December 2024: Renal Failure
https://read.qxmd.com/read/38442926/-construction-and-verification-of-a-nomogram-of-factors-influencing-the-risk-of-death-in-patient-with-sepsis-associated-thrombocytopenia
#40
JOURNAL ARTICLE
Chao Gu, Han Wang, Yanxiu Li, Quan Cao, Xiangrong Zuo
OBJECTIVE: To construct a nomogram prediction model for predicting the risk of death in patients with sepsis-associated thrombocytopenia (SAT) in intensive care unit (ICU) for early indentification and active intervention. METHODS: Clinical data of SAT patients admitted to ICU of the First Affiliated Hospital of Nanjing Medical University from December 2019 to August 2021 were retrospectively collected, including demographic data, laboratory indicators, etc. According to the prognosis at 28 days, the patients were divided into the death group and the survival group, and the differences of clinical variables between the two groups were compared...
February 2024: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
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