keyword
https://read.qxmd.com/read/38496890/the-relationship-between-lactate-dehydrogenase-to-albumin-ratio-and-all-cause-mortality-during-icu-stays-in-patients-with-sepsis-a-retrospective-cohort-study-with-propensity-score-matching
#1
JOURNAL ARTICLE
Xiaoyue Guan, Lei Zhong, Jinyu Zhang, Jianhong Lu, Meng Yuan, Lili Ye, Jie Min
BACKGROUND: Sepsis is a prevalent and severe medical condition which is frequently observed in the intensive care unit (ICU). Although numerous biomarkers have been identified to predict the prognosis of sepsis, the lactate dehydrogenase to albumin ratio (LDH/ALB ratio) has not been extensively investigated. The principal objective of this study is to assess the relationship between LDH/ALB ratio and all-cause mortality in patients with sepsis. METHODS: This study included all adult critically ill patients with sepsis from the Medical Information Mart for Intensive Care IV (MIMIC-IV, version 2...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38491434/utilizing-the-national-early-warning-score-2-news2-to-confirm-the-impact-of-emergency-department-management-in-sepsis-patients-a-cohort-study-from-taiwan-1998-2020
#2
JOURNAL ARTICLE
Ming-Shun Hsieh, Kuan-Chih Chiu, Amrita Chattopadhyay, Tzu-Pin Lu, Shu-Hui Liao, Chia-Ming Chang, Yi-Chen Lee, Wei-En Lo, Vivian Chia-Rong Hsieh, Sung-Yuan Hu, Chorng-Kuang How
BACKGROUND: Most sepsis patients could potentially experience advantageous outcomes from targeted medical intervention, such as fluid resuscitation, antibiotic administration, respiratory support, and nursing care, promptly upon arrival at the emergency department (ED). Several scoring systems have been devised to predict hospital outcomes in sepsis patients, including the Sequential Organ Failure Assessment (SOFA) score. In contrast to prior research, our study introduces the novel approach of utilizing the National Early Warning Score 2 (NEWS2) as a means of assessing treatment efficacy and disease progression during an ED stay for sepsis...
March 15, 2024: International Journal of Emergency Medicine
https://read.qxmd.com/read/38490519/identification-of-18%C3%AE-glycyrrhetinic-acid-as-an-agt-inhibitor-against-lps-induced-myocardial-dysfunction-via-high-throughput-screening
#3
JOURNAL ARTICLE
Mengying Shi, Shujing Zhang, Jiabing Rong, Zetao Heng, Yinchuan Xu, Yi Wang, Zhaocai Zhang
Sepsis induced myocardial dysfunction (SIMD) is a serious complication of sepsis. There is increasing evidence that the renin-angiotensin system (RAS) is activated in SIMD. Angiotensinogen (AGT) is a precursor of the RAS, and the inhibition of AGT may have significant cardiovascular benefits. But until now, there have been no reports of small molecule drugs targeting AGT. In this study, we designed a promoter-luciferase based system to screen for novel AGT inhibitors to alleviate SIMD. As a result of high-throughput screening, a total of 5 compounds from 351 medicinal herb-derived natural compounds were found inhibiting AGT...
March 13, 2024: Biochemical Pharmacology
https://read.qxmd.com/read/38489973/meta-analysis-of-evaluating-neuron-specific-enolase-as-a-serum-biomarker-for-sepsis-associated-encephalopathy
#4
JOURNAL ARTICLE
Jiyun Hu, Shucai Xie, Weiping Xia, Fang Huang, Biaoxiang Xu, Zhihong Zuo, Ya Liao, Zhaoxin Qian, Lina Zhang
INTRODUCTION: Brain dysfunction in sepsis is known as Sepsis-associated encephalopathy (SAE), which often results in severe cognitive and neurological sequelae and increases the risk of death. Neuron specific enolase (NSE) may serve as an important neurocritical biomarker for detection and longitudinal monitoring in SAE patients. Our Meta-analysis aimed to explore the diagnostic and prognostic value of serum NSE in SAE patients. Currently, no systematic Review and Meta-analysis have been assessed that NSE as a biomarker of SAE...
March 14, 2024: International Immunopharmacology
https://read.qxmd.com/read/38489892/americanin-b-inhibits-pyroptosis-in-lipopolysaccharide-induced-septic-encephalopathy-mice-through-targeting-nlrp3-protein
#5
JOURNAL ARTICLE
Yeshu Liu, Xiaohu Yao, Yanqiu Yang, Yan Mi, Yingjie Wang, Shaowen Tan, Mingxia Fang, Qingqi Meng, Gang Chen, Ning Li, Yue Hou
BACKGROUND: Sepsis is considered as a severe illness due to its high mortality. Sepsis can cause septic encephalopathy, thus leading to brain injury, behavioral and cognitive dysfunction. Pyroptosis is a type of regulated cell death (RCD) and takes a crucial part in occurrence and development of sepsis. Americanin B (AMEB) is a lignan compounds, which is extracted from Vernicia fordii. In our previous study, AMEB could inhibit microglial activation in inflammatory cell model. However, the function of AMEB in septic encephalopathy mice is uncertain...
March 8, 2024: Phytomedicine
https://read.qxmd.com/read/38489677/c3ar1-is-a-regulatory-factor-associated-with-coagulation-cascade-and-inflammation-in-sepsis
#6
JOURNAL ARTICLE
Xuanrong Ren, Qinghui Fu
Sepsis is a leading cause of mortality in intensive care units. Sepsis is associated with activation of the coagulation cascade and inflammation. The aim of this study was to identify coagulation-related genes in sepsis that may provide translational potential therapeutic targets. The datasets GSE28750, GSE95233, and GSE65682 were downloaded from the gene expression omnibus database. Consensus-weighted gene co-expression network analysis (WGCNA) was used to identify sepsis modules. Gene set enrichment analysis was used to identify genes enriched in the coagulation cascade...
March 15, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38489347/identifying-prognostic-factors-for-survival-in-intensive-care-unit-patients-with-sirs-or-sepsis-by-machine-learning-analysis-on-electronic-health-records
#7
JOURNAL ARTICLE
Maximiliano Mollura, Davide Chicco, Alessia Paglialonga, Riccardo Barbieri
BACKGROUND: Systemic inflammatory response syndrome (SIRS) and sepsis are the most common causes of in-hospital death. However, the characteristics associated with the improvement in the patient conditions during the ICU stay were not fully elucidated for each population as well as the possible differences between the two. GOAL: The aim of this study is to highlight the differences between the prognostic clinical features for the survival of patients diagnosed with SIRS and those of patients diagnosed with sepsis by using a multi-variable predictive modeling approach with a reduced set of easily available measurements collected at the admission to the intensive care unit (ICU)...
March 2024: PLOS Digit Health
https://read.qxmd.com/read/38484192/successful-management-of-neutropenic-sepsis-is-key-to-better-survival-of-patients-with-blood-cancer-in-sri-lanka-real-world-data-from-the-resource-limited-setting
#8
JOURNAL ARTICLE
Saman Hewamana, Thurairajah Skandarajah, Chathuri Jayasinghe, Samadhi Deshapriya, Dilip Gayashan, Natasha Peiris, Mahesh Harischandra, Prasanna Gunasena, Gnani Somasundaram, Vadivelu Srinivasan, Surjit Somiah, Chandana Wickramarathna, Sangeetha Hewawasam, Jayantha Balawardena, Gehan Arseculeratne, Rohini Wadanamby, Geethani Galagoda, Bandula Wijesiriwardana
PURPOSE: Sepsis is the main cause of nonrelapse mortality, and there are no published data on applicability of supportive care protocols from high-income countries such as Sri Lanka. The aim of the study was to investigate management and mortality of neutropenic episodes among Hemato-Oncology patients. MATERIALS AND METHODS: Retrospective analysis of clinical characteristics, management, morbidity, and mortality of neutropenic Hemato-Oncology patients presented to the Lanka Hospital Blood Cancer Centre from January 1, 2019 to December 31, 2019 was performed...
March 2024: JCO global oncology
https://read.qxmd.com/read/38484156/b-1a-cells-scavenge-nets-to-attenuate-sepsis
#9
JOURNAL ARTICLE
Kensuke Murata, Atsushi Murao, Chuyi Tan, Ping Wang, Monowar Aziz
B-1a cells, a regulatory subset of B lymphocytes, produce natural IgM and IL-10. Neutrophil extracellular traps (NETs) play a crucial role in pathogen defense, but their excessive formation during sepsis can cause further inflammation and tissue damage. In sepsis, extracellular cold-inducible RNA-binding protein (eCIRP), a damage-associated molecular pattern, is released to induce NET formation. We hypothesize that B-1a cells clear NETs to prevent sepsis-induced injury. Sepsis in mice was induced by injecting 1 × 107 and 5 × 107 CFU E...
March 14, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38483177/exploring-the-antibacterial-activity-and-cellular-fates-of-enterobactin-drug-conjugates-that-target-gram-negative-bacterial-pathogens
#10
JOURNAL ARTICLE
Chuchu Guo, Elizabeth M Nolan
ConspectusSiderophores are secondary metabolites utilized by bacteria to acquire iron (Fe), an essential transition metal nutrient. Fe levels in the host environment are tightly regulated and can be further restricted to starve invading bacterial pathogens in a host-defense process known as nutritional immunity. To survive and colonize the Fe-limited host environment, bacteria produce siderophores and express cognate siderophore transport machinery. These active transport pathways present an opportunity for selective and efficient drug delivery into bacterial cells, motivating decades of research on synthetic siderophore-antibiotic conjugates (SACs) as a Trojan-horse strategy for the development of targeted antibiotics...
March 14, 2024: Accounts of Chemical Research
https://read.qxmd.com/read/38481931/decoding-hepatic-portal-venous-gas-a-case-report
#11
Iulian A Dogaru, Daniela E Gheoca Mutu, Bogdan M Ursuț, Florin M Filipoiu, Adrian D Tulin
Hepatic portal venous gas (HPVG) is an infrequent and life-threatening condition with high morbidity and mortality rates, which consists of the presence of gas in the portal vein and its branches. Improvements in imaging technologies have led to the diagnosis of HPVG in less severe circumstances, which, in turn, has only determined a small amelioration of the prognosis. We present a rare case of HPVG subsequent to paralytic ileus in a patient who attained long-term survival after the surgical treatment was performed...
February 2024: Curēus
https://read.qxmd.com/read/38481153/bloodstream-infection-clusters-for-critically-ill-patients-analysis-of-two-center-retrospective-cohorts
#12
JOURNAL ARTICLE
Lei Wang, Li Zhang, Xiaolong Huang, Hao Xu, Wei Huang
BACKGROUND: Bloodstream infections (BSI) are highly prevalent in hospitalized patients requiring intensive care. They are among the most serious infections and are highly associated with sepsis or septic shock, which can lead to prolonged hospital stays and high healthcare costs. This study aimed at establishing an easy-to-use nomogram for predicting the prognosis of patients with BSI. METHODS: In retrospective study, records of patients with BSI admitted to the intensive care unit (ICU) over the period from Jan 1st 2016 to Dec 31st 2021 were included...
March 13, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38480612/prognostic-role-of-urinary-ketone-body-in-patients-with-sepsis-associated-encephalopathy-without-hepatic-failure-a-retrospective-cohort-study
#13
JOURNAL ARTICLE
Tian Ruan, Ya Wu, Chuanning Liu, Mu Xu, Jianbo Yu
Sepsis-associated encephalopathy (SAE) is defined as a dysfunction of the central nervous system experienced during sepsis with variable clinical features. The study aims to identify the prognostic role of urinary ketone bodies in relation to clinical outcomes in patients with SAE. The Medical Information Mart for Intensive Care III (MIMIC-III) database was used to conduct a retrospective cohort study. We recruited 427 patients with SAE admitted to the intensive care unit (ICU) from the MIMIC-III database. Patients with SAE were divided into a survival group (380 patients) and a non-survival group (47 patients)...
March 13, 2024: Internal and Emergency Medicine
https://read.qxmd.com/read/38480496/obesity-is-associated-with-improved-early-survival-but-increased-late-mortality-in-surgical-patients-with-sepsis-a-propensity-matched-analysis
#14
JOURNAL ARTICLE
Anahita Jalilvand, Megan Ireland, Courtney Collins, Whitney Kellett, Scott Strassel, Robert Tamer, Wendy Wahl, Jon Wisler
INTRODUCTION: While obesity is a risk factor for post-operative complications, its impact following sepsis is unclear. The primary objective of this study was to evaluate the association between obesity and mortality following admission to the surgical ICU (SICU) with sepsis. METHODS: We conducted a single center retrospective review of SICU patients grouped into obese (n = 766, BMI ≥30 kg/m2) and non-obese (n = 574, BMI 18-29.9 kg/m2) cohorts. Applying 1:1 propensity matching for age, sex, comorbidities, SOFA, and transfer status, demographic data, comorbidities, and sepsis presentation were compared between groups...
March 14, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38476769/spink1-is-a-potential-diagnostic-and-prognostic-biomarker-for-sepsis
#15
JOURNAL ARTICLE
Dexiu Chen, Zhangjing Shi, Xiaolan Gao, Yuxiang Yang, Xianying Lei, Yingchun Hu
PURPOSE: There are no satisfactory diagnostic biomarkers for sepsis. Accordingly, this study screened biomarkers valuable for sepsis diagnosis and prognosis using data-independent acquisition (DIA) combined with clinical data analysis. PATIENTS AND METHODS: Serine protease inhibitor Kazal-type 1 (SPINK1) is a differentially expressed protein that was screened using DIA and bioinformatics in sepsis patients (n = 22) and healthy controls (n = 10). The plasma SPINK1 levels were detected using an enzyme-linked immunosorbent assay (ELISA) in an expanded population (sepsis patients, n = 52; healthy controls, n = 10)...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38476471/prognostic-value-of-macrophage-inflammatory-protein-3alpha-mip3-alpha-and-severity-scores-in-elderly-patients-with-sepsis
#16
JOURNAL ARTICLE
Min Liu, Yun-Jiao Duan, Ye Zhang, Jun Yang, Bing Wei, Junyu Wang
OBJECTIVE: This study examines the effectiveness of MIP-3alpha and severity scores in determining the prognosis of elderly sepsis patients. METHODS: From October 2020 to April 2021, a total of 171 elderly sepsis patients were admitted to the Emergency Department of the Shijingshan Branch of Beijing Chaoyang Hospital, Capital Medical University. According to the 28-day mortality rate, they were divided into two groups: survivors (48 cases) and deaths (123 cases)...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38474222/antiseptic-functions-of-cgk012-against-hmgb1-mediated-septic-responses
#17
JOURNAL ARTICLE
Yun Jin Park, Jong Beom Heo, Yoon-Jung Choi, Sanghee Cho, Taeho Lee, Gyu Yong Song, Jong-Sup Bae
High mobility group box 1 (HMGB1), a protein with important functions, has been recognized as a potential therapeutic target for the treatment of sepsis. One possible mechanism for this is that inhibiting HMGB1 secretion can exert antiseptic effects, which can restore the integrity of the vascular barrier. (7S)-(+)-cyclopentyl carbamic acid 8,8-dimethyl-2-oxo-6,7-dihydro-2H,8H-pyrano[3,2-g]chromen-7-yl-ester (CGK012) is a newly synthesized pyranocoumarin compound that could function as a novel small-molecule inhibitor of the Wnt/β-catenin signaling pathway...
March 4, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473915/roles-of-lncrnas-in-nf-%C3%AE%C2%BAb-mediated-macrophage-inflammation-and-their-implications-in-the-pathogenesis-of-human-diseases
#18
REVIEW
Jae-Joon Shin, Jeongkwang Park, Hyeung-Seob Shin, Imene Arab, Kyoungho Suk, Won-Ha Lee
Over the past century, molecular biology's focus has transitioned from proteins to DNA, and now to RNA. Once considered merely a genetic information carrier, RNA is now recognized as both a vital element in early cellular life and a regulator in complex organisms. Long noncoding RNAs (lncRNAs), which are over 200 bases long but do not code for proteins, play roles in gene expression regulation and signal transduction by inducing epigenetic changes or interacting with various proteins and RNAs. These interactions exhibit a range of functions in various cell types, including macrophages...
February 25, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38472708/role-of-source-control-in-critically-ill-candidemic-patients-a-multicenter-retrospective-study
#19
JOURNAL ARTICLE
Markos Marangos, Petros Ioannou, Laurence Senn, Anastasia Spiliopoulou, Sotiris Tzalis, Fevronia Kolonitsiou, Maria Valta, Sofia Kokkini, Jean-Luc Pagani, Dimitra Stafylaki, Fotini Paliogianni, Fotini Fligou, Diamantis P Kofteridis, Frédéric Lamoth, Matthaios Papadimitriou-Olivgeris
PURPOSE: Candidemia is associated with high mortality especially in critically ill patients. Our aim was to identify predictors of mortality among critically ill patients with candidemia with a focus on early interventions that can improve prognosis. METHODS: Multicenter retrospective study. SETTING: This retrospective study was conducted in Intensive Care Units from three European university hospitals from 2015 to 2021. Adult patients with at least one positive blood culture for Candida spp...
March 12, 2024: Infection
https://read.qxmd.com/read/38471792/patient-stratification-using-plasma-cytokines-and-their-regulators-in-sepsis-relationship-to-outcomes-treatment-effect-and-leucocyte-transcriptomic-subphenotypes
#20
JOURNAL ARTICLE
David Benjamin Antcliffe, Yuxin Mi, Shalini Santhakumaran, Katie L Burnham, A Toby Prevost, Josie K Ward, Timothy J Marshall, Claire Bradley, Farah Al-Beidh, Paula Hutton, Stuart McKechnie, Emma E Davenport, Charles J Hinds, Cecilia M O'Kane, Daniel Francis McAuley, Manu Shankar-Hari, Anthony C Gordon, Julian C Knight
RATIONALE: Heterogeneity of the host response within sepsis, acute respiratory distress syndrome (ARDS) and more widely critical illness, limits discovery and targeting of immunomodulatory therapies. Clustering approaches using clinical and circulating biomarkers have defined hyper-inflammatory and hypo-inflammatory subphenotypes in ARDS associated with differential treatment response. It is unknown if similar subphenotypes exist in sepsis populations where leucocyte transcriptomic-defined subphenotypes have been reported...
March 12, 2024: Thorax
keyword
keyword
43262
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.