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https://www.readbyqxmd.com/read/29786868/cis-acting-allele-specific-expression-ase-differences-induced-by-alcohol-and-impacted-by-sex-as-well-as-parental-genotype-of-origin
#1
Chiao-Ling Lo, Lawrence Lumeng, Richard L Bell, Tiebing Liang, Amy C Lossie, Williams M Muir, Feng C Zhou
BACKGROUND: Alcohol use disorders (AUDs) are influenced by complex interactions between the genetics of the individual and their environment. We have previously identified hundreds of polygenic genetic variants between the selectively bred high and low alcohol drinking (HAD and LAD) rat lines. Here we report allele specific expression (ASE) differences, between the HAD2 and LAD2 rat lines. METHODS: The HAD2 and LAD2 rats which have been sequenced were reciprocally crossed to generate 10 litters of F1 progeny...
May 22, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29786625/differences-in-glenohumeral-joint-rotation-and-peak-power-output-between-super-league-and-championship-rugby-league-players
#2
Matthew R Haines
Haines, MR. Differences in glenohumeral joint rotation and peak power output between Super League and Championship Rugby League players. J Strength Cond Res 32(6): 1685-1691, 2018-Rugby league is a high-intensity sport with large impact forces sustained during play, resulting in high prevalence of shoulder injury. Consequently, shoulder strength and player power are important considerations for injury prevention and performance. Additionally, professional teams regularly compete against semiprofessional teams, where differences in physical conditioning could be marked...
June 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29785967/eighty-routes-to-a-ribonucleotide-world-dispersion-and-stringency-in-the-decisive-selection
#3
Michael Yarus
We examine the initial emergence of genetics; that is, of an inherited chemical capability. The crucial actors are ribonucleotides, occasionally meeting in a prebiotic landscape. Previous work identified six influential variables during such random ribonucleotide pooling. Geochemical pools can be in periodic danger (e.g., from tides) or constant danger (e.g., from unfavorable weather). Such pools receive Gaussian nucleotide amounts sporadically, at random times, or get varying substrates simultaneously. Pools use cross-templated RNA synthesis (5'-5' product from 5'-3' template) or para-templated (5'-5' product from 5'-5' template) synthesis...
May 21, 2018: RNA
https://www.readbyqxmd.com/read/29785052/observation-of-anisotropic-magneto-peltier-effect-in-nickel
#4
Ken-Ichi Uchida, Shunsuke Daimon, Ryo Iguchi, Eiji Saitoh
The Peltier effect, discovered in 1834, converts a charge current into a heat current in a conductor, and its performance is described by the Peltier coefficient, which is defined as the ratio of the generated heat current to the applied charge current1,2 . To exploit the Peltier effect for thermoelectric cooling or heating, junctions of two conductors with different Peltier coefficients have been believed to be indispensable. Here we challenge this conventional wisdom by demonstrating Peltier cooling and heating in a single material without junctions...
May 21, 2018: Nature
https://www.readbyqxmd.com/read/29784983/thermodynamic-and-crystallographic-model-for-anion-uptake-by-hydrated-calcium-aluminate-afm-an-example-of-molybdenum
#5
Nicolas C M Marty, Sylvain Grangeon, Erik Elkaïm, Christophe Tournassat, Clémence Fauchet, Francis Claret
Amongst all cement phases, hydrated calcium aluminate (AFm) plays a major role in the retention of anionic species. Molybdenum (Mo), whose 93 Mo isotope is considered a major steel activation product, will be released mainly under the form of MoO4 2- in a radioactive waste repository. Understanding its fate is of primary importance in a safety analysis of such disposal. This necessitates models that can both predict quantitatively the sorption of Mo by AFm and determine the nature of the sorption process (i...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29784732/duty-to-provide-care-to-ebola-patients-the-perspectives-of-guinean-lay-people-and-healthcare-providers
#6
Lonzozou Kpanake, Tamba Kallas Tonguino, Paul Clay Sorum, Etienne Mullet
AIM: To examine the views of Guinean lay people and healthcare providers (HCPs) regarding the acceptability of HCPs' refusal to provide care to Ebola patients. METHOD: From October to December 2015, lay people (n=252) and HCPs (n=220) in Conakry, Guinea, were presented with 54 sample case scenarios depicting a HCP who refuses to provide care to Ebola patients and were instructed to rate the extent to which this HCP's decision is morally acceptable. The scenarios were composed by systematically varying the levels of four factors: (1) the risk of getting infected, (2) the HCP's working conditions, (3) the HCP's family responsibilities and (4) the HCP's professional status...
May 21, 2018: Journal of Medical Ethics
https://www.readbyqxmd.com/read/29784484/advanced-concepts-of-atrioventricular-nodal-electrophysiology-observations-on-the-mechanisms-of-atrioventricular-nodal-reciprocating-tachycardias
#7
REVIEW
Giuseppe Bagliani, Fabio M Leonelli, Roberto De Ponti, Luigi Padeletti
Atrioventricular node reentrant tachycardia (AVNRT) is a supraventricular arrhythmia easily diagnosed by 12-lead electrocardiogram. What is far more challenging, is the understanding of the reentrant circuit in its typical and atypical presentations. The function of the atrioventricular node is still incomplete and this knowledge gap is reflected in the reconstruction of the pathways used by AVNRT in its multiform presentations. This article illustrates the heterogeneous electrocardiographic manifestations of AVNRT...
June 2018: Cardiac Electrophysiology Clinics
https://www.readbyqxmd.com/read/29782849/seizure-modulation-by-sleep-and-sleep-state
#8
Carl W Bazil
Sleep is a dynamic process, during which the electrical rhythms of the brain orchestrate a complicated progression of changing frequencies, patterns and connectivity. Each stage of sleep is different electrophysiologically from wakefulness, and from other sleep stages. It should be no surprise, then, that the various sleep states influence the origin, suppression, and spread of seizures, and that different seizure types are affected in individual (and sometimes contradictory) ways. While much of the electrical symphony that occurs in both normal and epileptic brains is incompletely understood, at the basic level some interesting and often clinically important influences of the various sleep states have been identified...
May 18, 2018: Brain Research
https://www.readbyqxmd.com/read/29782811/the-longitudinal-relationship-between-motor-competence-and-measures-of-fatness-and-fitness-from-childhood-into-adolescence
#9
Rodrigo Antunes Lima, Anna Bugge, Annette K Ersbøll, David F Stodden, Lars B Andersen
OBJECTIVES: To examine longitudinal (seven years) relationships among cardiorespiratory fitness (VO2peak ), body fatness, and motor competence. METHOD: Data were collected as part of the Copenhagen School Child Intervention Study (CoSCIS). Body fatness was assessed by the sum of four skinfolds. VO2peak was measured directly in a continuous running protocol. Motor competence was assessed using the Körperkoordinationtest für Kinder. This study used multilevel linear mixed models to evaluate the reciprocal longitudinal association between body fatness, VO2peak , and motor competence...
May 18, 2018: Jornal de Pediatria
https://www.readbyqxmd.com/read/29782640/drug-gut-microbiota-interactions-implications-for-neuropharmacology
#10
REVIEW
Jacinta Walsh, Brendan T Griffin, Gerard Clarke, Niall P Hyland
The fate and activity of drugs are frequently dictated not only by the host per se but also by the microorganisms present in the gastrointestinal tract. The gut microbiome is known to, both directly and indirectly, affect drug metabolism. More evidence now hints at the impact that drugs can have on the function and composition of the gut microbiome. Both microbiota-mediated alterations in drug metabolism and drug-mediated alterations in the gut microbiome can have beneficial or detrimental effects on the host...
May 21, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29781855/improving-senescent-wound-healing-with-local-and-systemic-therapies
#11
Caroline Szpalski, Parag Butala, Meredith T Vandegrift, Denis Knobel, Robert J Allen, Pierre B Saadeh, Stephen M Warren
The population is aging, and the prevalence of chronic wounds is increasing. Because neovascularization is essential for tissue repair and both local and systemic factors affect new blood vessel formation, we hypothesize that altering either pathway would reciprocally enhance wound healing in the aged. To test this hypothesis, p53 was locally suppressed and endothelial progenitor cells (EPCs) were systemically mobilized in a murine model of senescent wound healing.Bilateral 6-mm full-thickness stented wounds were made on the dorsum of Zmpste24 mice...
May 17, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29781659/nicotine-deprivation-increases-pain-intensity-neurogenic-inflammation-and-mechanical-hyperalgesia-among-daily-tobacco-smokers
#12
Joseph W Ditre, Emily L Zale, Lisa R LaRowe, Jesse D Kosiba, Martin J De Vita
An evolving reciprocal model posits that pain and tobacco smoking behavior interact in the manner of a positive feedback loop, resulting in greater pain and the maintenance of nicotine dependence. There is also reason to believe that abstaining from smoking may increase pain during the early stages of smoking cessation. The goal of this study was to test the effects of nicotine deprivation on experimental pain reactivity. Daily tobacco cigarette smokers (N = 165; 43% female) were randomized to either extended nicotine deprivation (12-24 hr smoking abstinence), minimal deprivation (2 hr smoking abstinence), or continued smoking conditions, prior to undergoing pain induction via topical capsaicin...
May 21, 2018: Journal of Abnormal Psychology
https://www.readbyqxmd.com/read/29781653/daily-assessment-of-interpersonal-factors-to-predict-suicidal-ideation-and-non-suicidal-self-injury-in-psychiatric-inpatients
#13
Michael J Kyron, Geoff R Hooke, Andrew C Page
OBJECTIVE: The study assessed suicidal ideation and interpersonal variables to explore the extent to which (a) changes in interpersonal factors predicted future suicidal ideation and (b) changes in either predicted nonsuicidal self-injury. METHOD: In total, 1,044 patients (72.3% Female; mean age = 41.95) at a psychiatric inpatient facility were assessed daily for suicidal thoughts. If patients indicated suicidal thinking (n = 417), their feelings of perceived burdensomeness and thwarted belongingness were assessed...
June 2018: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/29781086/reductions-of-intimate-partner-violence-resulting-from-supplementing-children-with-omega-3-fatty-acids-a-randomized-double-blind-placebo-controlled-stratified-parallel-group-trial
#14
Jill Portnoy, Adrian Raine, Jianghong Liu, Joseph R Hibbeln
Omega-3 supplementation has been found to reduce externalizing behavior in children. Reciprocal models of parent-child behavior suggest that improving child behavior could lead to improvements in parent behavior, however no study has examined whether omega-3 supplementation in children could reduce intimate partner violence or child maltreatment by their adult caregivers. In this randomized, double-blind, placebo-controlled, stratified, parallel group trial, a community sample of children were randomized to receive either a fruit drink containing 1 gm of omega-3 fats (Smartfish Recharge; Omega-3 group, n = 100) or the same fruit drink without omega-3's (Placebo group, n = 100)...
May 20, 2018: Aggressive Behavior
https://www.readbyqxmd.com/read/29780308/motor-preparation-disrupts-proactive-control-in-the-stop-signal-task
#15
Wuyi Wang, Sien Hu, Jaime S Ide, Simon Zhornitsky, Sheng Zhang, Angela J Yu, Chiang-Shan R Li
In a study of the stop signal task (SST) we employed Bayesian modeling to compute the estimated likelihood of stop signal or P(Stop) trial by trial and identified regional processes of conflict anticipation and response slowing. A higher P(Stop) is associated with prolonged go trial reaction time (goRT)-a form of sequential effect-and reflects proactive control of motor response. However, some individuals do not demonstrate a sequential effect despite similar go and stop success (SS) rates. We posited that motor preparation may disrupt proactive control more in certain individuals than others...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29780036/revised-phylogeny-of-the-cellulose-synthase-gene-superfamily-insights-into-cell-wall-evolution
#16
Alan Little, Julian G Schwerdt, Neil J Shirley, Shi F Khor, Kylie Neumann, Lisa A O'Donovan, Jelle Lahnstein, Helen M Collins, Marilyn Henderson, Geoffrey B Fincher, Rachel A Burton
Cell walls are crucial for the integrity and function of all land plants, and are of central importance in human health, livestock production, and as a source of renewable bioenergy. Many enzymes that mediate the biosynthesis of cell wall polysaccharides are encoded by members of the large cellulose synthase (CesA) gene superfamily. Here, we analyzed 29 sequenced genomes and 17 transcriptomes to revise the phylogeny of the CesA gene superfamily in angiosperms. Our results identify ancestral gene clusters that predate the monocot-eudicot divergence and reveal several novel evolutionary observations, including the expansion of the Poaceae-specific cellulose synthase-like CslF family to the graminids and restiids and the characterisation of a previously unreported eudicot lineage, CslM, that forms a reciprocally monophyletic eudicot-monocot grouping with the CslJ clade...
May 20, 2018: Plant Physiology
https://www.readbyqxmd.com/read/29779459/the-role-of-control-in-intimate-partner-violence-a-study-in-dutch-forensic-outpatients
#17
Bruno Verschuere, Joan van Horn, Nannet Buitelaar
Johnson argued that coercive control is crucial in explaining heterogeneity in intimate partner violence, with such violence being more frequent, less reciprocal, and more often male-to-female aggression when it serves to exercise control over the partner. We assessed 280 Dutch forensic outpatients who had recently engaged in intimate partner violence on nonaggressive coercive control. Control showed significant, small to moderate, associations with more frequent past year acts of psychological aggression, physical assault, and sexual coercion and more frequently resulted in partner injury...
May 1, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29779094/-cell-grafting-a-new-approach-for-transferring-cytoplasmic-or-nuclear-genome-between-plants
#18
Vladimir Sidorov, Charles Armstrong, Thomas Ream, Xudong Ye, Annie Saltarikos
A new method based on mixing and wounding of callus tissue was used to transfer plastid or nuclear DNA between cells. Methods alternative to sexual hybridization can be powerful tools for crop improvement. We have developed a new hybridization technology based on wounding a mixed population of cells of two parents growing in vitro as callus ("cell grafting"), and have demonstrated the utility of this system for plastid or nuclear genome transfer. In our proof-of concept experiments, non-organized growing tissue (callus) from tobacco var...
May 19, 2018: Plant Cell Reports
https://www.readbyqxmd.com/read/29778958/building-on-common-ground-to-address-biodiversity-conflicts-and-foster-collaboration-in-environmental-management
#19
Lou Lecuyer, Rehema M White, Birgit Schmook, Sophie Calmé
Conservation biology faces critical challenges that require collaborative approaches, including novel strategies to support interactions among actors in biodiversity conflicts. The goals of this study were to investigate the concept of common ground across multiple issues and to explore its practical application for the support of environmental management. We conceptually defined common ground as the areas of relevance underlying the suite of issues expressed by people regarding environmental management in a particular context...
May 17, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29777391/shaping-ability-of-reciprocating-single-file-systems-in-severely-curved-canals-waveone-and-reciproc-versus-waveone-gold-and-reciproc-blue
#20
Sebastian Bürklein, Stefanie Flüch, Edgar Schäfer
The aim was to compare the canal straightening of M-wire [Reciproc (VDW, Munich, Germany) and WaveOne (Dentsply Maillefer, Ballaigues, Switzerland)] and gold- and blue-wire heat-treated [Reciproc blue (VDW) and WaveOne Gold (Dentsply Maillefer)] instruments in severely curved root canals. A total of 80 root canals in extracted human teeth with angles of curvatures ranging between 25° and 35° and radii ranging between 3.1 and 8.5 mm were divided into four groups (n = 20). Based on radiographs taken prior to instrumentation, the groups were balanced with respect to the angle and the radius of canal curvature (P = 1...
May 18, 2018: Odontology
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