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https://www.readbyqxmd.com/read/28813498/phylogeography-of-bivalve-meretrix-petechialis-in-the-northwestern-pacific-indicated-by-mitochondrial-and-nuclear-dna-data
#1
Xiaoxuan Wang, Lingfeng Kong, Jun Chen, Akihiko Matsukuma, Qi Li
The marine clam Meretrix petechialis is an important economic shellfish species in Northwestern Pacific, but little is known about its phylogeographical pattern. Here, we analyzed 311 samples from 22 locations along the northwestern Pacific using combined profiling of one mitochondrial gene (the first subunit of cytochrome coxidase, COI) and one nuclear DNA marker (the internal transcribed spacer region 1, ITS-1) to investigate contemporary genetic structure and reconstruct phylogenetic history of this species...
2017: PloS One
https://www.readbyqxmd.com/read/28812581/nfia-co-localizes-with-ppar%C3%AE-and-transcriptionally-controls-the-brown-fat-gene-program
#2
Yuta Hiraike, Hironori Waki, Jing Yu, Masahiro Nakamura, Kana Miyake, Gaku Nagano, Ryo Nakaki, Ken Suzuki, Hirofumi Kobayashi, Shogo Yamamoto, Wei Sun, Tomohisa Aoyama, Yusuke Hirota, Haruya Ohno, Kenji Oki, Masayasu Yoneda, Andrew P White, Yu-Hua Tseng, Aaron M Cypess, Therese J Larsen, Naja Z Jespersen, Camilla Scheele, Shuichi Tsutsumi, Hiroyuki Aburatani, Toshimasa Yamauchi, Takashi Kadowaki
Brown fat dissipates energy as heat and protects against obesity. Here, we identified nuclear factor I-A (NFIA) as a transcriptional regulator of brown fat by a genome-wide open chromatin analysis of murine brown and white fat followed by motif analysis of brown-fat-specific open chromatin regions. NFIA and the master transcriptional regulator of adipogenesis, PPARγ, co-localize at the brown-fat-specific enhancers. Moreover, the binding of NFIA precedes and facilitates the binding of PPARγ, leading to increased chromatin accessibility and active transcription...
August 14, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28812568/gene-expression-plasticity-as-a-mechanism-of-coral-adaptation-to-a-variable-environment
#3
Carly D Kenkel, Mikhail V Matz
Local adaptation is ubiquitous, but the molecular mechanisms that give rise to this ecological phenomenon remain largely unknown. A year-long reciprocal transplant of mustard hill coral (Porites astreoides) between a highly environmentally variable inshore habitat and a more stable offshore habitat demonstrated that populations exhibit phenotypic signatures that are consistent with local adaptation. We characterized the genomic basis of this adaptation in both coral hosts and their intracellular symbionts (Symbiodinium sp...
November 7, 2016: Nature ecology & evolution
https://www.readbyqxmd.com/read/28812268/oxytocin-and-human-evolution
#4
C Sue Carter
A small, but powerful neuropeptide, oxytocin coordinates processes that are central to both human reproduction and human evolution. Also embedded in the evolution of the human nervous system are unique pathways necessary for modern human sociality and cognition. Oxytocin is necessary for facilitating the birth process, especially in light of anatomical restrictions imposed by upright human locomotion, which depends on a fixed pelvis. Oxytocin, by facilitating birth, allowed the development of a large cortex and a protective bony cranium...
August 16, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28811640/a-reciprocal-interaction-between-%C3%AE-catenin-and-osterix-in-cementogenesis
#5
Hwajung Choi, Tak-Heun Kim, Siqin Yang, Jeong-Chae Lee, Hyung-Keun You, Eui-Sic Cho
Although accumulating evidence indicates that both β-catenin and osterix (Osx) are essential for bone and tooth development, few studies have investigated the interaction of these two key proteins in the context of cementogenesis. In this study, we used transgenic mice with constitutively active β-catenin and inactive Osx in the dental mesenchyme to address this question. We found that cementoblasts with constitutively active β-catenin require Osx to produce excessive cellular cementum, and that ablation of Osx prevents this abnormal accumulation...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811623/immune-dysregulation-in-patients-with-carpal-tunnel-syndrome
#6
Gila Moalem-Taylor, Benny Baharuddin, Barbara Bennett, Arun V Krishnan, William Huynh, Matthew C Kiernan, Cindy Shin-Yi Lin, Boaz Shulruf, Elizabeth Keoshkerian, Barbara Cameron, Andrew Lloyd
Peripheral immunity plays a key role in maintaining homeostasis and conferring crucial neuroprotective effects on the injured nervous system, while at the same time may contribute to increased vulnerability to neuropathic pain. Little is known about the reciprocal relationship between entrapment neuropathy and peripheral immunity. This study investigated immune profile in patients with carpal tunnel syndrome (CTS), the most prevalent entrapment neuropathy. All patients exhibited neurophysiological abnormalities in the median nerve, with the majority reporting neuropathic pain symptoms...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811188/familial-1p36-3-microduplication-resulting-from-a-1p-9q-non-reciprocal-translocation
#7
Valentine Marquet, Sylvie Bourthoumieu, Amelia Dobrescu, Cécile Laroche-Raynaud, Catherine Yardin
Unlike the 1p36 microdeletion syndrome, which has been extensively described, 1p36 microduplications have rarely been reported. We describe a three years old boy presenting with a severe global developmental delay and a few dysmorphic features. Cytogenetic analyses revealed a maternally inherited 3.35 Mb microduplication of chromosomal band 1p36.3. The maternal grand-father is also carrier of the same chromosomal rearrangement. Interestingly, the duplicated 1p36.3 segment was found to be localized at the telomeric end of the long arms of a chromosome 9, probably deriving from a 1p36...
August 12, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/28808850/non-rem-sleep-disordered-breathing-affects-performance-on-the-psychomotor-vigilance-task
#8
Takuro Kitamura, Soichiro Miyazaki, Hiroshi Kadotani, Takashi Kanemura, Harun Bin Sulaiman, Shoko Takeuchi, Takahisa Tabata, Hideaki Suzuki
PURPOSE: Although many studies have investigated the clinical importance of sleep apnea on rapid eye movement (REM) and non-REM (NREM) sleep, the relationship between behavioral performance and apneic events during different sleep phases remains unclear. In the present study, we sought to investigate the effect of sleep phase fragmentation due to sleep-disordered breathing (SDB) during REM and NREM on the vigilance and sustainability of attention based on psychomotor vigilance task (PVT) performance...
August 14, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28808639/comparison-of-cyclic-fatigue-life-of-nickel-titanium-files-an-examination-using-high-speed-camera
#9
Taha Özyürek, Neslihan Büşra Keskin, Fatma Furuncuoğlu, Uğur İnan
OBJECTIVES: To determine the actual revolutions per minute (rpm) values and compare the cyclic fatigue life of Reciproc (RPC, VDW GmbH), WaveOne (WO, Dentsply Maillefer), and TF Adaptive (TFA, Axis/SybronEndo) nickel-titanium (NiTi) file systems using high-speed camera. MATERIALS AND METHODS: Twenty RPC R25 (25/0.08), 20 WO Primary (25/0.08), and 20 TFA ML 1 (25/0.08) files were employed in the present study. The cyclic fatigue tests were performed using a dynamic cyclic fatigue testing device, which has an artificial stainless steel canal with a 60° angle of curvature and a 5-mm radius of curvature...
August 2017: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/28808570/nitric-oxide-cyclic-gmp-pathway-mediates-the-endothelin-1-upregulation-of-adiponectin-expression-in-rat-cardiomyocytes
#10
Bingyan Guo, Yongjun Li, Xin Jin, Suyun Liu, Chenglong Miao
Endothelin-1 (ET-1) serves an important role in the development of cardiac dysfunction and heart failure. ET-1 and angiotensin II (AngII) comprise a mutually reciprocal signalling network in the myocardium and serve similar or additive roles in the development of heart failure. Our previous study previously demonstrated that AngII upregulated the expression of APN in cardiomyocytes through an AngII receptor type 2/nitric oxide (NO)/cyclic GMP(cGMP)-dependent pathway. The purpose of the present study was to determine the effects of ET-1 and the additive effects of ET-1 and AngII on the gene expression and secretion of APN, and the underlying mechanisms involved...
September 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28808459/evaluation-of-apically-extruded-debris-during-root-canal-retreatment-using-protaper-next-and-reciproc-in-severely-curved-canals
#11
Giselle Nevares, Kaline Romeiro, Diana Albuquerque, Felipe Xavier, Howard Fogel, Laila Freire, Rodrigo Cunha
INTRODUCTION: To compare the apical extrusion of debris produced during root obturating material removal from severely curved root canals using either Reciproc (REC) or ProTaper Next (PTN) systems. METHODS AND MATERIALS: Twenty-six mesial canals of lower molars were instrumented, filled and allocated into two groups (n=13). Micro-computed tomographic images were performed to determine the root canal configuration (Vertucci's type IV) and initial volume of obturation...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/28808456/an-in-vitro-comparison-of-apically-extruded-debris-using-reciproc-protaper-universal-neolix-and-hyflex-in-curved-canals
#12
Hossein Labbaf, Kiumars Nazari Moghadam, Shahriar Shahab, Mahshid Mohammadi Bassir, Mohammad Amin Fahimi
INTRODUCTION: As a consequence of root canal preparation, dentinal chips, irrigants and pulp remnants are extruded into preradicular space. This phenomenon may lead to post endodontic flare-ups. The purpose of this study was to compare the amount of extruded debris with four endodontic NiTi engine-driven systems. METHODS AND MATERIALS: Sixty mesiobuccal roots of maxillary molars with 15-30˚ curvature were divided randomly into four groups (n=15). Each group was instrumented up to apical size of 25 using Reciproc, ProTaper Universal, Neolix and Hyflex...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/28808431/reconstructing-three-dimensional-protein-crystal-intensities-from-sparse-unoriented-two-axis-x-ray-diffraction-patterns
#13
Ti-Yen Lan, Jennifer L Wierman, Mark W Tate, Hugh T Philipp, Veit Elser, Sol M Gruner
Recently, there has been a growing interest in adapting serial microcrystallography (SMX) experiments to existing storage ring (SR) sources. For very small crystals, however, radiation damage occurs before sufficient numbers of photons are diffracted to determine the orientation of the crystal. The challenge is to merge data from a large number of such 'sparse' frames in order to measure the full reciprocal space intensity. To simulate sparse frames, a dataset was collected from a large lysozyme crystal illuminated by a dim X-ray source...
August 1, 2017: Journal of Applied Crystallography
https://www.readbyqxmd.com/read/28808029/elucidating-crosstalk-mechanisms-between-phosphorylation-and-o-glcnacylation
#14
Aneika C Leney, Dris El Atmioui, Wei Wu, Huib Ovaa, Albert J R Heck
Proteins can be modified by multiple posttranslational modifications (PTMs), creating a PTM code that controls the function of proteins in space and time. Unraveling this complex PTM code is one of the great challenges in molecular biology. Here, using mass spectrometry-based assays, we focus on the most common PTMs-phosphorylation and O-GlcNAcylation-and investigate how they affect each other. We demonstrate two generic crosstalk mechanisms. First, we define a frequently occurring, very specific and stringent phosphorylation/O-GlcNAcylation interplay motif, (pSp/T)P(V/A/T)(gS/gT), whereby phosphorylation strongly inhibits O-GlcNAcylation...
August 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28807600/methylglyoxal-synthase-regulates-cell-elongation-via-alterations-of-cellular-methylglyoxal-and-spermidine-content-in-bacillus-subtilis
#15
Sang-Min Shin, Sung-Hyun Song, Jin-Woo Lee, Min-Kyu Kwak, Sa-Ouk Kang
Methylglyoxal regulates cell division and differentiation through its interaction with polyamines. Loss of their biosynthesizing enzyme causes physiological impairment and cell elongation in eukaryotes. However, the reciprocal effects of methylglyoxal and polyamine production and its regulatory metabolic switches on morphological changes in prokaryotes have not been addressed. Here, Bacillus subtilis methylglyoxal synthase (mgsA) and polyamine biosynthesizing genes encoding arginine decarboxylase (SpeA), agmatinase (SpeB), and spermidine synthase (SpeE), were disrupted or overexpressed...
August 11, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28807094/mesonia-maritimus-sp-nov-isolated-from-seawater-of-the-south-sea-of-korea
#16
Hye-Ri Sung, Kiseong Joh, Kee-Sun Shin
A yellow-pigmented bacterial strain, originally designated 15-S14-6T, was isolated from the southern coastal waters of Korea and was subjected to taxonomic study using a polyphasic approach. Strain 15-S14-6T was Gram-staining-negative, flagellated, rod-shaped and aerobic. The strain grew optimally at 25-30 °C, in the presence of 2 % (w/v) NaCl and at pH 7.5-8.0. The results of phylogenetic analysis based on 16S rRNA gene sequences indicated that 15-S14-6T represented a member of the genus Mesonia and exhibited the highest sequence similarity (98...
August 15, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28806136/harnessing-olig2-function-in-tumorigenicity-and-plasticity-to-target-malignant-gliomas
#17
Jennifer Kosty, Fanghui Lu, Robert Kupp, Shwetal Mehta, Q Richard Lu
Glioblastoma (GBM) is the most prevalent and malignant brain tumor, displaying notorious resistance to conventional therapy, partially due to molecular and genetic heterogeneity. Understanding the mechanisms for gliomagenesis, tumor stem/progenitor cell propagation and phenotypic diversity is critical for devising effective and targeted therapy for this lethal disease. The basic helix-loop-helix transcription factor OLIG2, which is universally expressed in gliomas, has emerged as an important player in GBM cell reprogramming, genotoxic resistance, and tumor phenotype plasticity...
August 14, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28804693/the-ability-of-reciproc-instruments-to-reach-full-working-length-without-glide-path-preparation-a-clinical-retrospective-study
#18
Andreas Bartols, Bernt-Peter Robra, Winfried Walther
BACKGROUND: Reciproc instruments are the only contemporary root canal instruments where glide path preparation is no longer strictly demanded by the manufacturer. As the complete preparation of root canals is associated with success in endodontic treatment we wanted to assess the ability and find predictors for Reciproc instruments to reach full working length (RFWL) in root canals of maxillary molars in primary root canal treatment (1°RCTx) and retreatment (2°RCTx) cases. METHODS: This retrospective study evaluated 255 endodontic treatment cases of maxillary molars...
2017: PeerJ
https://www.readbyqxmd.com/read/28804465/personality-traits-related-to-binge-drinking-a-systematic-review
#19
REVIEW
Ana Adan, Diego A Forero, José Francisco Navarro
The pattern of alcohol consumption in the form of binge drinking (BD) or heavy episodic drinking has increased notably worldwide in recent years, especially among adolescent and young people, being currently recognized as a global health problem. Although only a minority of binge drinkers will develop a substance use disorder, BD may have negative personal and social consequences in the short and medium term. The objective of this article is to review the findings on personality traits related to binge drinkers and to emphasize the aspects that should be examined in order to make progress in this area...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28804390/relations-between-views-on-ageing-and-perceived-age-discrimination-a-domain-specific-perspective
#20
Peggy Voss, Julia K Wolff, Klaus Rothermund
This study investigates the relation between age stereotypes and perceived age discrimination. Existing evidence for such a relation is notoriously ambiguous with regard to its direction-age stereotypes can predict (perceived) discrimination, but experiencing discrimination may also change views on ageing-which is why we used a dataset with two waves to disentangle the direction of the associations. Considering research on the multi-dimensionality of views on ageing and perceived age discrimination, we addressed this question from a domain- and age group-specific perspective...
March 2017: European Journal of Ageing
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