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https://www.readbyqxmd.com/read/28444781/constructing-longitudinal-disease-progression-curves-using-sparse-short-term-individual-data-with-an-application-to-alzheimer-s-disease
#1
C A Budgeon, K Murray, B A Turlach, S Baker, V L Villemagne, S C Burnham
In epidemiology, cohort studies utilised to monitor and assess disease status and progression often result in short-term and sparse follow-up data. Thus, gaining an understanding of the full-term disease pathogenesis can be difficult, requiring shorter-term data from many individuals to be collated. We investigate and evaluate methods to construct and quantify the underlying long-term longitudinal trajectories for disease markers using short-term follow-up data, specifically applied to Alzheimer's disease. We generate individuals' follow-up data to investigate approaches to this problem adopting a four-step modelling approach that (i) determines individual slopes and anchor points for their short-term trajectory, (ii) fits polynomials to these slopes and anchor points, (iii) integrates the reciprocated polynomials and (iv) inverts the resulting curve providing an estimate of the underlying longitudinal trajectory...
April 25, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28444316/oxytocin-facilitates-reciprocity-in-social-communication
#2
Franny B Spengler, Dirk Scheele, Nina Marsh, Charlotte Kofferath, Aileen Flach, Sarah Schwarz, Birgit Stoffel-Wagner, Wolfgang Maier, René Hurlemann
Synchrony in social groups may confer significant evolutionary advantages by improving group cohesion and social interaction. However, the neurobiological mechanisms translating social synchrony into refined social information transmission between interacting individuals are still elusive. In two successively conducted experiments involving a total of 199 healthy volunteers, we explored the involvement of the neuropeptide oxytocin (OXT) in reciprocal social interaction. First, we show that synchronous social interactions evoke heightened endogenous OXT release in dyadic partners...
April 21, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28443644/a-reciprocal-regulatory-loop-between-taz-yap-and-g-protein-g%C3%AE-s-regulates-schwann-cell-proliferation-and-myelination
#3
Yaqi Deng, Lai Man Natalie Wu, Shujun Bai, Chuntao Zhao, Haibo Wang, Jincheng Wang, Lingli Xu, Masahide Sakabe, Wenhao Zhou, Mei Xin, Q Richard Lu
Schwann cell (SC) myelination in the peripheral nervous system is essential for motor function, and uncontrolled SC proliferation occurs in cancer. Here, we show that a dual role for Hippo effectors TAZ and YAP in SC proliferation and myelination through modulating G-protein expression and interacting with SOX10, respectively. Developmentally regulated mutagenesis indicates that TAZ/YAP are critical for SC proliferation and differentiation in a stage-dependent manner. Genome-wide occupancy mapping and transcriptome profiling reveal that nuclear TAZ/YAP promote SC proliferation by activating cell cycle regulators, while targeting critical differentiation regulators in cooperation with SOX10 for myelination...
April 26, 2017: Nature Communications
https://www.readbyqxmd.com/read/28443108/the-kinase-activity-of-calcineurin-b-like-interacting-protein-kinase-26-cipk26-influences-its-own-stability-and-that-of-the-aba-regulated-ubiquitin-ligase-keep-on-going-keg
#4
Wendy J Lyzenga, Victoria Sullivan, Hongxia Liu, Sophia L Stone
The Really Interesting New Gene (RING)-type E3 ligase, Keep on Going (KEG) plays a critical role in Arabidopsis growth after germination and the connections between KEG and hormone signaling pathways are expanding. With regards to abscisic acid (ABA) signaling, KEG targets ABA-responsive transcription factors abscisic acid insensitive 5, ABF1 and ABF3 for ubiquitination and subsequent degradation through the 26S proteasome. Regulation of E3 ligases through self-ubiquitination is common to RING-type E3 ligases and ABA promotes KEG self-ubiquitination and degradation...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28443038/mother-infant-and-extra-dyadic-interactions-with-a-new-social-partner-developmental-trajectories-of-early-social-abilities-during-play
#5
Roberta Fadda, Loredana Lucarelli
Mother-infant interactions during feeding and play are pivotal experiences in the development of infants' early social abilities (Stern, 1985, 1995; Biringen, 2000). Stern indicated distinctive characteristics of mother-infant interactions, respectively, during feeding and play, suggesting to evaluate both to better describe the complexity of such early affective and social experiences (Stern, 1996). Moreover, during the first years of life, infants acquire cognitive and social skills that allow them to interact with new social partners in extra-dyadic interactions...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28442775/deterministic-bragg-coherent-diffraction-imaging
#6
Konstantin M Pavlov, Vasily I Punegov, Kaye S Morgan, Gerd Schmalz, David M Paganin
A deterministic variant of Bragg Coherent Diffraction Imaging is introduced in its kinematical approximation, for X-ray scattering from an imperfect crystal whose imperfections span no more than half of the volume of the crystal. This approach provides a unique analytical reconstruction of the object's structure factor and displacement fields from the 3D diffracted intensity distribution centred around any particular reciprocal lattice vector. The simple closed-form reconstruction algorithm, which requires only one multiplication and one Fourier transformation, is not restricted by assumptions of smallness of the displacement field...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28442721/near-field-surface-plasmons-on-quasicrystal-metasurfaces
#7
Quanlong Yang, Xueqian Zhang, Shaoxian Li, Quan Xu, Ranjan Singh, Yongmin Liu, Yanfeng Li, Sergey S Kruk, Jianqiang Gu, Jiaguang Han, Weili Zhang
Excitation and manipulation of surface plasmons (SPs) are essential in developing cutting-edge plasmonic devices for medical diagnostics, biochemical spectroscopy and communications. The most common approach involves designing an array of periodic slits or grating apertures that enables coupling of the incident light to the SP modes. In recent years, plasmonic resonances, including extraordinary optical transmission through periodic arrays, quasicrystals and random aperture arrays, have been investigated in the free space...
December 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28442117/tuberculosis-toxoplasmosis-co-infection-in-egyptian-patients-a-reciprocal-impact
#8
Mervat Mashaly, Nairmen Nabih, Iman M Fawzy, Abeer A El Henawy
OBJECTIVE: To assess the concurrent toxoplasmosis infection in Egyptian TB patients and the impact of each infection on the other in terms of increased severity of TB or reactivation of latent Toxoplasma infection. METHODS: Three hundred suspected pulmonary TB cases were initially screened for TB using direct Ziehl Neelsen staining and Lowenstein Jensen culture of their sputa. Rifampicin resistance was detected by Xpert MTB/RIF assay. Control group of 30 age and sex-matched healthy individuals negative for TB was included for comparison...
March 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28442055/home-care-packages-insights-into-the-experiences-of-older-people-leading-up-to-the-introduction-of-consumer-directed-care-in-australia
#9
Jenny Day, Ann Clare Thorington Taylor, Peter Summons, Pamela Van Der Riet, Sharyn Hunter, Jane Maguire, Sophie Dilworth, Helen Bellchambers, Sarah Jeong, Gunilla Haydon, Margaret Harris, Isabel Higgins
This paper reports phase one, conducted from March to June 2015, of a two-phase, qualitative descriptive study designed to explore the perceptions and experiences of older people before and after the introduction of consumer directed care (CDC) to home care packages (HCP) in Australia. Eligible consumers with a local HCP provider were mailed information about the study. Data collection occurred before the introduction of CDC and included face-to-face, in-depth interviews, summaries of interviews, field notes and reflective journaling...
April 2017: Australian Journal of Primary Health
https://www.readbyqxmd.com/read/28441794/reciprocal-interactions-of-leukemic-cells-with-bone-marrow-stromal-cells-promote-enrichment-of-leukemic-stell-cell-compartments-in-response-to-curcumin-and-daunorubicin
#10
Saeed Mohammadi, Mohsen Nikbakht, Seyed Mehdi Sajjadi, Fariba Rad, Bahram Chahardouli, Javid Sabour Takanlu, Shahrbano Rostami, Kamran Alimoghaddam, Ardeshir Ghavamzadeh, Seyed H Ghaffari
A predominant challenge in developing curative leukemia therapy is interactions of leukemic cells with the bone marrow stromal microenvironment. We aimed to investigate the role of stromal cells, such as bone marrow mesenchymal stromal cells (BMSCs) and osteoblasts (OBs), in curcumin (CUR) and daunorubicin (DNR) induced apoptosis of acute myeloid leukemia (AML) cells. We used KG1 and U937 as leukemia cell line models and treated them with CUR and DNR. The cells were then co-cultured with BMSCs or a combination of BMSCs and OBs as feeders...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28440361/the-role-of-echocardiography-in-fetal-tachyarrhythmia-diagnosis-a-burden-for-the-pediatric-cardiologist-and-a-review-of-the-literature
#11
Liliana Gozar, Claudiu Marginean, Rodica Toganel, Iolanda Muntean
Supraventricular tachyarrhythmia represents the most frequent fetal dysrhythmia. In the lack of diagnosis and treatment these fetuses may develop hydrops and even death. For the therapeutic approach it is important to establish the diagnosis of the type of supraventricular tachycardia. In this paper we report 29 cases with different types of supraventricular tachycardia in which the diagnosis was established using our own protocol, which allowed us to make the difference between the types of tachycardia (atrioventricular reentry tachycardia due to the accessory pathway, atrial ectopic tachycardia and permanent junctional reciprocal tachycardia)...
April 22, 2017: Medical Ultrasonography
https://www.readbyqxmd.com/read/28439888/emotional-feeding-and-emotional-eating-reciprocal-processes-and-the-influence-of-negative-affectivity
#12
Silje Steinsbekk, Edward D Barker, Clare Llewellyn, Alison Fildes, Lars Wichstrøm
Emotional eating, that is, eating more in response to negative mood, is often seen in children. But the origins of emotional eating remain unclear. In a representative community sample of Norwegian 4-year-olds followed up at ages 6, 8, and 10 years (analysis sample: n = 801), one potential developmental pathway was examined: a reciprocal relation between parental emotional feeding and child emotional eating. The results revealed that higher levels of emotional feeding predicted higher levels of emotional eating and vice versa, adjusting for body mass index and initial levels of feeding and eating...
April 25, 2017: Child Development
https://www.readbyqxmd.com/read/28438331/-the-intestinal-microbiota-a-new-player-in-depression
#13
M Meyrel, L Varin, B Detaint, F Mouaffak
Depression is the leading cause of disability in the world according to the World Health Organization. The effectiveness of the available antidepressant therapies is limited. Data from the literature suggest that some subtypes of depression may be associated with chronic low grade inflammation. The uncovering of the role of intestinal microbiota in the development of the immune system and its bidirectional communication with the brain have led to growing interest on reciprocal interactions between inflammation, microbiota and depression...
April 21, 2017: L'Encéphale
https://www.readbyqxmd.com/read/28438120/transcriptomic-analysis-links-gene-expression-to-unilateral-pollen-pistil-reproductive-barriers
#14
Amanda K Broz, Rafael F Guerrero, April M Randle, You Soon Baek, Matthew W Hahn, Patricia A Bedinger
BACKGROUND: Unilateral incompatibility (UI) is an asymmetric reproductive barrier that unidirectionally prevents gene flow between species and/or populations. UI is characterized by a compatible interaction between partners in one direction, but in the reciprocal cross fertilization fails, generally due to pollen tube rejection by the pistil. Although UI has long been observed in crosses between different species, the underlying molecular mechanisms are only beginning to be characterized...
April 24, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28437755/an-in-vitro-study-of-cartilage-meniscus-tribology-to-understand-the-changes-caused-by-a-meniscus-implant
#15
Sara Ehsani Majd, Aditya Iman Rizqy, Hans J Kaper, Tannin A Schmidt, Roel Kuijer, Prashant K Sharma
Active lifestyles increase the risk of meniscal injury. A permanent meniscus implant of polycarbonate urethane (PCU) is a promising treatment to postpone/prevent total knee arthroplasty. Study of the changes in articular cartilage tribology in the presence of PCU is essential in developing the optimum meniscus implant. Therefore, a cartilage-meniscus reciprocating, sliding model was developed in vitro, mimicking the stance and swing phases of the gait cycle. The meniscus was further replaced with PCU and surface-modified PCUs (with C18 chains, mono-functional polydimethylsiloxane groups and mono-functional polytetrafluoroethylene groups) to study the changes...
April 18, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28436980/amygdala-inputs-to-prefrontal-cortex-guide-behavior-amid-conflicting-cues-of-reward-and-punishment
#16
Anthony Burgos-Robles, Eyal Y Kimchi, Ehsan M Izadmehr, Mary Jane Porzenheim, William A Ramos-Guasp, Edward H Nieh, Ada C Felix-Ortiz, Praneeth Namburi, Christopher A Leppla, Kara N Presbrey, Kavitha K Anandalingam, Pablo A Pagan-Rivera, Melodi Anahtar, Anna Beyeler, Kay M Tye
Orchestrating appropriate behavioral responses in the face of competing signals that predict either rewards or threats in the environment is crucial for survival. The basolateral nucleus of the amygdala (BLA) and prelimbic (PL) medial prefrontal cortex have been implicated in reward-seeking and fear-related responses, but how information flows between these reciprocally connected structures to coordinate behavior is unknown. We recorded neuronal activity from the BLA and PL while rats performed a task wherein competing shock- and sucrose-predictive cues were simultaneously presented...
April 24, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28436513/self-inverted-reciprocation-of-an-oil-droplet-on-a-surfactant-solution
#17
Yusuke Satoh, Yoshimi Sogabe, Katsuhiko Kayahara, Shinpei Tanaka, Masaharu Nagayama, Satoshi Nakata
Self-motion of an oil droplet was investigated on a sodium dodecyl sulfate (SDS) aqueous phase. With an increase in the concentration of SDS, the nature of self-motion of a butyl salicylate (BS) droplet as the oil droplet was changed, i.e., no motion, reciprocation with a small amplitude, and reciprocation with a large amplitude, which was a value close to the half-length of the chamber. The interfacial tension, contact angle, and convective flow around the droplet were measured to clarify the driving force of reciprocation...
April 24, 2017: Soft Matter
https://www.readbyqxmd.com/read/28436407/design-of-a-pulsatile-dc-electromagnetic-blood-pump-for-ecmo
#18
Jingjing Liu, Bin Ge, Tong Lu
BACKGROUND: Extracorporeal membrane oxygenation (ECMO) has developed rapidly and become a significant treatment for emergency. Current blood pumps for ECMO have different disadvantages. OBJECTIVE: To design a pulsatile DC electromagnetic blood pump for ECMO. METHODS: The design is presented with a driving principle which the rectilinear reciprocation of a magnet inside energized solenoids is implemented, and with a structure of solenoids with compensation coils...
April 14, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/28435860/onymity-promotes-cooperation-in-social-dilemma-experiments
#19
Zhen Wang, Marko Jusup, Rui-Wu Wang, Lei Shi, Yoh Iwasa, Yamir Moreno, Jürgen Kurths
One of the most elusive scientific challenges for over 150 years has been to explain why cooperation survives despite being a seemingly inferior strategy from an evolutionary point of view. Over the years, various theoretical scenarios aimed at solving the evolutionary puzzle of cooperation have been proposed, eventually identifying several cooperation-promoting mechanisms: kin selection, direct reciprocity, indirect reciprocity, network reciprocity, and group selection. We report the results of repeated Prisoner's Dilemma experiments with anonymous and onymous pairwise interactions among individuals...
March 2017: Science Advances
https://www.readbyqxmd.com/read/28435364/influence-of-reuse-and-cervical-preflaring-on-the-fracture-strength-of-reciprocating-instruments
#20
Claudio Maniglia-Ferreira, Fabio de Almeida Gomes, Tatyana Ximenes, Murilo Alves Teixeira Neto, Thiane Elys Arruda, Giovani Gonçalves Ribamar, Luis Flávio Gaspar Herculano
OBJECTIVE: This study sought to assess the influence of cervical preflaring and reuse after resterilization, on fracture strength and plastic deformation and/or surface cracking in reciprocating nickel-titanium [NiTi] endodontic instruments after root canal instrumentation of extracted human teeth. MATERIALS AND METHODS: Forty engine-driven reciprocating NiTi instruments (20 Reciproc(®) [RC], VDW; 20 WaveOne(®) [WO], Dentsply) were used in root canal instrumentation of extracted human molars...
January 2017: European Journal of Dentistry
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