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https://www.readbyqxmd.com/read/28719886/a-longitudinal-study-of-the-reciprocal-relationship-between-ever-smoking-and-urgency-in-early-adolescence
#1
Jessica L Burris, Elizabeth Riley, Gabriella E Puleo, Gregory T Smith
BACKGROUND: Among early adolescents in the United States (U.S.), the prevalence of cigarette smoking is at its lowest level in recent decades. Nonetheless, given the risks of smoking in early development, it remains critically important to study both risk factors for smoking and risks from smoking. This longitudinal study with U.S. early adolescents examines smoking initiation and tests a model of reciprocal prediction between ever smoking and the personality trait of urgency (i.e., mood-based impulsivity), a trait that increases risk for multiple forms of dysfunction...
July 11, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28719590/pericyte-expressed-tie2-controls-angiogenesis-and-vessel-maturation
#2
Martin Teichert, Laura Milde, Annegret Holm, Laura Stanicek, Nicolas Gengenbacher, Soniya Savant, Tina Ruckdeschel, Zulfiyya Hasanov, Kshitij Srivastava, Junhao Hu, Stella Hertel, Arne Bartol, Katharina Schlereth, Hellmut G Augustin
The Tie receptors with their Angiopoietin ligands act as regulators of angiogenesis and vessel maturation. Tie2 exerts its functions through its supposed endothelial-specific expression. Yet, Tie2 is also expressed at lower levels by pericytes and it has not been unravelled through which mechanisms pericyte Angiopoietin/Tie signalling affects angiogenesis. Here we show that human and murine pericytes express functional Tie2 receptor. Silencing of Tie2 in pericytes results in a pro-migratory phenotype. Pericyte Tie2 controls sprouting angiogenesis in in vitro sprouting and in vivo spheroid assays...
July 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/28718342/reconsidering-the-roles-of-gratitude-and-indebtedness-in-social-exchange
#3
Cong Peng, Rob M A Nelissen, Marcel Zeelenberg
Receiving favors is often a mixed blessing and commonly triggers two emotions: the positive emotion gratitude and negative emotion indebtedness. In three studies, we examined the hypothesis that gratitude and indebtedness have distinct functions in social exchange. Contrary to current views, we believe that the function of gratitude does not primarily reside in facilitating social exchange. Instead, we propose that indebtedness motivates people to repay favours received, and thus accounts for most of the prosocial effects commonly attributed to gratitude...
July 18, 2017: Cognition & Emotion
https://www.readbyqxmd.com/read/28718281/long-distance-modulation-of-disorder-to-order-in-protein-allostery
#4
Jingheng Wang, Gregory S Custer, Dorothy Beckett, Silvina Matysiak
Elucidation of the molecular details of allosteric communication between distant sites in a protein is key to understanding and manipulating many biological regulatory processes. Although protein disorder is acknowledged to play an important thermodynamic role in allostery, the molecular mechanisms by which this disorder is harnessed for long distance communication are known for a limited number of systems. Transcription repression by the E. coli biotin repressor, BirA, is allosterically activated by binding of the small molecule effector biotinoyl-5'-AMP...
July 18, 2017: Biochemistry
https://www.readbyqxmd.com/read/28717880/environmental-exposure-does-not-explain-putative-maladaptation-in-road-adjacent-populations
#5
Steven P Brady
While the ecological consequences of roads are well described, little is known of their role as agents of natural selection, which can shape adaptive and maladaptive responses in populations influenced by roads. This knowledge gap persists despite a growing appreciation for the influence of evolution in human-altered environments. There, insights indicate that natural selection typically results in local adaptation. Thus, populations influenced by road-induced selection should evolve fitness advantages in their local environment...
July 17, 2017: Oecologia
https://www.readbyqxmd.com/read/28716050/working-for-patient-safety-a-qualitative-study-of-women-s-help-seeking-during-acute-perinatal-events
#6
Nicola Mackintosh, Susanna Rance, Wendy Carter, Jane Sandall
BACKGROUND: Women and their relatives can play an important role in early detection and help seeking for acute perinatal events. Recent UK reports indicate that patient-professional partnership in 'working for safety' can be difficult to achieve in practice, sometimes with catastrophic consequences. This research explored the experiences of women and relatives who had experienced early warning signs about their condition and sought help in escalating care. METHODS: Secondary analysis of case study data which included qualitative interviews with 22 women purposively sampled on account of experiencing a step up in care and 4 of their relatives from two NHS Trusts in England during 2010...
July 17, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28715600/ultrastructural-study-of-the-neural-microcircuits-in-the-sensory-epithelium-of-the-paratympanic-organ-of-the-chicken
#7
F Giannessi, L Ryskalin, R Ruffoli
The paratympanic organ (PTO) is a sensory organ located in the medial wall of the tympanic cavity of birds. The organ looks like a small tapering vesicle, and is equipped with a sensory epithelium formed by supporting cells (SCs) and Type II hair cells (Type II-HCs). The function of the PTO has not yet been precisely defined. The prevailing current hypothesis is that the PTO assesses the air pressure exerted on the external surface of the tympanic membrane. The PTO could may thus function as a barometer and, in flying birds, also as an altimeter...
July 1, 2017: Archives Italiennes de Biologie
https://www.readbyqxmd.com/read/28714144/cerebellins-are-differentially-expressed-in-selective-subsets-of-neurons-throughout-the-brain
#8
Erica Seigneur, Thomas C Südhof
Cerebellins are secreted hexameric proteins that form tripartite complexes with the presynaptic cell-adhesion molecules neurexins or 'deleted-in-colorectal-cancer' (DCC), and the postsynaptic glutamate-receptor-related proteins GluD1 and GluD2. These tripartite complexes are thought to regulate synapses. However, cerebellins are expressed in multiple isoforms whose relative distributions and overall functions are not understood. Three of the four cerebellins, Cbln1, Cbln2, and Cbln4, autonomously assemble into homohexamers, whereas the Cbln3 requires Cbln1 for assembly and secretion...
July 16, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28714082/in-situ-macrophage-phenotypic-transition-is-affected-by-altered-cellular-composition-prior-to-acute-sterile-muscle-injury
#9
Andreas Patsalos, Attila Pap, Tamas Varga, Gyorgy Trencsenyi, Gerardo Alvarado Contreras, Ildiko Garai, Zoltan Papp, Balazs Dezso, Eva Pintye, Laszlo Nagy
Skeletal muscle regeneration is a complex interplay between various cell types including invading macrophages. Their recruitment to damaged tissues upon acute sterile injuries is necessary for necrotic debris clearance and for coordination of tissue regeneration. This highly dynamic process is characterized by an in-situ transition of infiltrating monocytes from an inflammatory (Ly6C(high) ) to a repair (Ly6C(low) ) macrophage phenotype. The importance of the macrophage phenotypic shift and the cross-talk of the local muscle tissue with the infiltrating macrophages during tissue regeneration upon injury are not fully understood and their study lacks adequate methodology...
July 17, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28713808/children-s-autonomic-nervous-system-reactivity-moderates-the-relations-between-family-adversity-and-sleep-problems-in-latino-5-year-olds-in-the-chamacos-study
#10
Abbey Alkon, W Thomas Boyce, Torsten B Neilands, Brenda Eskenazi
Sleep problems are common for young children especially if they live in adverse home environments. Some studies investigate if young children may also be at a higher risk of sleep problems if they have a specific biological sensitivity to adversity. This paper addresses the research question, does the relations between children's exposure to family adversities and their sleep problems differ depending on their autonomic nervous system's sensitivity to challenges? As part of a larger cohort study of Latino, low-income families, we assessed the cross-sectional relations among family demographics (education, marital status), adversities [routines, major life events (MLE)], and biological sensitivity as measured by autonomic nervous system (ANS) reactivity associated with parent-rated sleep problems when the children were 5 years old...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28713762/comparison-of-the-shaping-ability-of-waveone-reciprocating-files-with-or-without-glide-path-in-simulated-curved-s-shaped-root-canals
#11
Ayca Yilmaz, Enver Sedat Kucukay, Murat Istektepe, Selen Nihal Sisli, Handan Ersev, Isil Karagoz-Kucukay
OBJECTIVES: The aim was to compare the shaping ability of WaveOne reciprocating files with or without glide path in simulated curved S-shaped root canals. MATERIALS AND METHODS: Forty ISO #15, 0.02 taper, clear resin Endo Training Bloc-S blocks were studied. The simulated curved S-shaped canals were dyed using ink, preinstrumentation images were scanned, and resin blocks were prepared and divided into Group A: PathFile and WaveOne and Group B: WaveOne. All canals were postoperatively scanned...
June 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/28713318/the-bidirectional-relationship-between-positive-mental-health-and-social-rhythm-in-college-students-a-three-year-longitudinal-study
#12
Dan Cai, Meixia Zhu, Muyu Lin, Xiao Chi Zhang, Jürgen Margraf
Social rhythm refers to the general regularity of engaging in basic social activities during the week, and was found to be associated with individuals' positive mental health. The present study investigated the relationship between social rhythm and emotional well-being in a cohort of 2,031 college students over 3 years with a cross-lagged longitudinal panel design. Results revealed that regularity of social rhythm positively predicted emotional well-being in the following year, and vice versa, when the level of both factors in the previous year was controlled...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28713145/reciprocal-relationships-something-for-everyone
#13
Nina Tumosa
Reciprocal relationships based on mutual goals, respect and trust are key to maintaining working relationships and getting reliable research results. Yet relationship building is not a concept taught in academia. These skills are often learned the hard way, with singular solutions found for case-by-case scenarios. Several journeys to identify the components, barriers and rewards of reciprocal relationships are discussed.
2017: Narrative Inquiry in Bioethics
https://www.readbyqxmd.com/read/28712675/ejaculates-are-not-used-as-nuptial-gifts-in-simultaneously-hermaphroditic-snails
#14
Monica Lodi, Fedde W Meijer, Joris M Koene
Promoted by sexual selection, males usually adopt different ways to increase their fertilization chances. In many insect taxa males donate nuptial gifts, together with sperm, which represent a valuable additional nutrient source that females can use to provision eggs. This has also been suggested to occur in simultaneous hermaphrodites, organisms with both sex functions. In theory, donation of nuptial gifts or extra nutrients might work in hermaphrodites that mate unilaterally (one-way donation of ejaculates), but will not be effective when these organisms mate reciprocally (mutual exchange of ejaculates), since on average each partner would receive the amount it also transfers...
May 25, 2017: Zoology: Analysis of Complex Systems, ZACS
https://www.readbyqxmd.com/read/28711935/association-of-msin1-with-mtorc2-ras-and-akt-reveals-a-crucial-domain-on-msin1-involved-in-akt-phosphorylation
#15
Chien-An Yao, Sara Ortiz-Vega, Yun-Ya Sun, Chiang-Ting Chien, Jen-Hua Chuang, Yenshou Lin
mSin1 is a unique component within the mammalian target of rapamycin (mTOR) complex 2 (mTORC2), which is responsible for cellular morphology and glucose metabolism. The association between mSin1 and other mTORC2 components, as well as their functions, has been explored previously; nevertheless, the mapping of the various binding domains of the components is lacking. Based on an evolutionary analysis of the gene, we constructed various fragments and truncated-forms of mSin1. We characterized the individual binding sites of mSin1 with its various partners, including mTOR, Rictor, Ras, and Akt...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28710773/reciprocal-modulation-of-helper-th1-and-th17-cells-by-the-%C3%AE-2-adrenergic-receptor-agonist-drug-terbutaline
#16
Catalina M Carvajal Gonczi, Mahdieh Tabatabaei Shafiei, Ashley East, Erika Martire, Meagane H I Maurice-Ventouris, Peter J Darlington
Catecholamine hormones are powerful regulators of the immune system produced by the sympathetic nervous system. They regulate the adaptive immune system by altering T cell differentiation into T helper (Th) 1 and Th2 cell subsets, but the effect on Th17 cells is not known. Th17 cells, defined in part by chemokine receptor CCR6 and cytokine IL-17A, are crucial for mediating certain pathogen-specific responses, and are linked with several autoimmune diseases. We demonstrated that a proportion of human Th17 cells express β2-adrenergic receptor, a G protein coupled receptor that responds to catecholamines...
July 15, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28710588/identification-and-molecular-characterization-of-a-trans-acting-small-interfering-rna-producing-locus-regulating-leaf-rust-responsive-gene-expression-in-wheat-triticum-aestivum-l
#17
Summi Dutta, Dhananjay Kumar, Shailendra Jha, Kumble Vinod Prabhu, Manish Kumar, Kunal Mukhopadhyay
A novel leaf rust responsive ta-siRNA-producing locus was identified in wheat showing similarity to 28S rRNA and generated four differentially expressing ta-siRNAs by phasing which targeted stress responsive genes. Trans-acting-small interfering RNAs (Ta-siRNAs) are plant specific molecules generally involved in development and are also stress responsive. Ta-siRNAs identified in wheat till date are all responsive to abiotic stress only. Wheat cultivation is severely affected by rusts and leaf rust particularly affects grain filling...
July 14, 2017: Planta
https://www.readbyqxmd.com/read/28709959/reciprocal-relationships-between-emotion-regulation-and-motives-for-eating-palatable-foods-in-african-american-adolescents
#18
Catheryn A Orihuela, Sylvie Mrug, Mary M Boggiano
This study examines possible bidirectional relationships between emotion regulation and motives related to consuming palatable foods during adolescence. Participants included 79 adolescents (96% African American) who took part in Waves 2 and 3 of the Coping with Violence Study. The youth were recruited from four public middle schools serving low income, urban communities in Birmingham, AL. Participants completed self-report measures of emotion regulation and indicated different motives for consuming tasty foods and drinks at both waves...
July 11, 2017: Appetite
https://www.readbyqxmd.com/read/28709276/kaiser-bessel-basis-for-particle-mesh-interpolation
#19
Xingyu Gao, Jun Fang, Han Wang
In this work, we introduce the Kaiser-Bessel interpolation basis for the particle-mesh interpolation in the fast Ewald method. A reliable a priori error estimate is developed to measure the accuracy of the force computation in correlated charge systems, and is shown to be effective in optimizing the shape parameter of the Kaiser-Bessel basis in terms of accuracy. By comparing the optimized Kaiser-Bessel basis with the traditional B-spline basis, we demonstrate that the former is more accurate than the latter in part of the working parameter space, say, a relatively small real-space cutoff, a relatively small reciprocal space mesh, and a relatively large truncation of basis...
June 2017: Physical Review. E
https://www.readbyqxmd.com/read/28708994/unshielding-exosomal-rna-unleashes-tumor-growth-and-metastasis
#20
Irina Matei, Han Sang Kim, David Lyden
Reciprocal interactions between tumor cells and their microenvironment drive cancer progression and therapy resistance. In this issue, Nabet et al. demonstrate that dynamic feedback between tumor and stroma subverts normal inflammatory responses by triggering the release of exosomes containing unshielded RNAs that activate pattern recognition receptors, thereby promoting tumor growth and metastasis.
July 13, 2017: Cell
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