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MR and Cerebral

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https://www.readbyqxmd.com/read/29666881/pathological-factors-contributing-to-crossed-cerebellar-diaschisis-in-cerebral-gliomas-a-study-combining-perfusion-diffusion-and-structural-mr-imaging
#1
Xiaoxue Liu, Jianrui Li, Qiang Xu, Dante Mantini, Peng Wang, Yuan Xie, Yifei Weng, Chiyuan Ma, Kangjian Sun, Zhiqiang Zhang, Guangming Lu
PURPOSE: To investigate imaging features of crossed cerebellar diaschisis (CCD) in cerebral gliomas, and its underlying pathophysiological mechanisms. METHODS: Thirty-three pre-surgical patients with cerebral gliomas and 33 healthy controls underwent arterial spin-labeling, diffusion tensor imaging, and high-resolution T1-weighted imaging using MRI, in order to estimate cerebral blood flow (CBF), white matter integrity, and lesion volume, respectively. Asymmetry indices of CBF in the cerebellum were used for evaluating the level of CCD in the patients...
April 17, 2018: Neuroradiology
https://www.readbyqxmd.com/read/29665290/timely-visualization-of-the-collaterals-formed-during-acute-ischemic-stroke-with-fe-3-o-4-nanoparticle-based-mr-imaging-probe
#2
Ting Wang, Yi Hou, Bo Bu, Wenxin Wang, Tiancong Ma, Chunyan Liu, Lan Lin, Lin Ma, Xin Lou, Mingyuan Gao
Ischemic stroke is one of the major leading causes for long-term disability and mortality. Collateral vessels provide an alternative pathway to protect the brain against ischemic injury after arterial occlusion. Aiming at visualizing the collaterals occurring during acute ischemic stroke, an integrin αv β3 -specific Fe3 O4 -Arg-Gly-Asp (RGD) nanoprobe is prepared for magnetic resonance imaging (MRI) of the collaterals. Rat models are constructed by occluding the middle cerebral artery for imaging studies of cerebral ischemia and ischemia-reperfusion on 7...
April 17, 2018: Small
https://www.readbyqxmd.com/read/29663187/mri-patient-selection-for-endovascular-thrombectomy-in-acute-ischemic-stroke-correlation-between-pretreatment-diffusion-weighted-imaging-and-outcome-scores
#3
Marcello Longo, Gianmarco Bernava, Alessandro Calamuneri, Antonio A Caragliano, Antonio Pitrone, Rosario Papa, Enricomaria Mormina, Francesca Granata, Rosa Musolino, Agostino Tessitore, Giuseppe Centorrino, Federico Midiri, Federica Vernuccio, Sergio L Vinci
INTRODUCTION: Eligibility for endovascular treatment (EVT) in patients with acute ischemic stroke (AIS) depends, amongst other factors, on CT- or MR-based scores. The aim of this study was to investigate the role of Alberta Stroke Program Early CT score based on diffusion weighted imaging (MR-ASPECT) in the assessment of brain damage pre-EVT, patient selection for EVT and outcome. MATERIALS AND METHODS: We included in this study patients with National Institute of Health stroke score (NIHSS) at admission ≥ 8, MR-ASPECT ≥ 5 and anterior AIS, who were treated with EVT in our hospital...
April 16, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29656926/resting-state-cerebral-blood-flow-with-arterial-spin-labeling-mri-in-developing-human-brains
#4
Feng Liu, Yunsuo Duan, Bradley S Peterson, Iris Asllani, Fernando Zelaya, David Lythgoe, Alayar Kangarlu
The development of brain circuits is coupled with changes in neurovascular coupling, which refers to the close relationship between neural activity and cerebral blood flow (CBF). Studying the characteristics of CBF during resting state in developing brain can be a complementary way to understand the functional connectivity of the developing brain. Arterial spin labeling (ASL), as a noninvasive MR technique, is particularly attractive for studying cerebral perfusion in children and even newborns. We have collected pulsed ASL data in resting state for 47 healthy subjects from young children to adolescence (aged from 6 to 20 years old)...
March 24, 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29652306/-assessment-of-clinical-manifestations-and-treatment-of-post-stroke-depression-in-young-patients-with-ischemic-stroke
#5
M L Chukhlovina, A A Chukhlovin
AIM: To consider clinical manifestations and treatment of post-stroke depression in young patients with carotid ischemic stroke. MATERIAL AND METHODS: Forty patients, 24 women and 16 men, aged from 18 to 45 years old, diagnosed with ICD-10 post-stroke depression were examined. All patients underwent neurological examination, brain MRI and MR-angiography of cerebral vessels. The following psychometric tests were used: MMSE, Hamilton depression scale, CES-D depression scale, a questionnaire on nocturnal sleep assessment, and Epworth Sleepiness Scale...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29652234/computer-assisted-planning-for-the-insertion-of-stereoelectroencephalography-electrodes-for-the-investigation-of-drug-resistant-focal-epilepsy-an-external-validation-study
#6
Vejay N Vakharia, Rachel Sparks, Roman Rodionov, Sjoerd B Vos, Christian Dorfer, Jonathan Miller, Daniel Nilsson, Martin Tisdall, Stefan Wolfsberger, Andrew W McEvoy, Anna Miserocchi, Gavin P Winston, Aidan G O'Keeffe, Sebastien Ourselin, John S Duncan
OBJECTIVE One-third of cases of focal epilepsy are drug refractory, and surgery might provide a cure. Seizure-free outcome after surgery depends on the correct identification and resection of the epileptogenic zone. In patients with no visible abnormality on MRI, or in cases in which presurgical evaluation yields discordant data, invasive stereoelectroencephalography (SEEG) recordings might be necessary. SEEG is a procedure in which multiple electrodes are placed stereotactically in key targets within the brain to record interictal and ictal electrophysiological activity...
April 13, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29651771/remote-brain-microhaemorrhages-may-predict-haematoma-in-glioma-patients-treated-with-radiation-therapy
#7
Augustin Lecler, Frédérique Charbonneau, Dimitri Psimaras, Marie-Astrid Metten, Antoine Gueguen, Khe Hoang Xuan, Loic Feuvret, Julien Savatovsky
OBJECTIVES: To evaluate the prevalence of cerebral remote microhaemorrhages (RMH) and remote haematomas (RH) using magnetic resonance susceptibility-weighted imaging (SWI) among patients treated for gliomas during follow-up. METHODS: We conducted a retrospective single centre longitudinal study on 58 consecutive patients treated for gliomas from January 2009 through December 2010. Our institutional review board approved this study. We evaluated the presence and number of RMH and RH found outside the brain tumour on follow-up MR imaging...
April 12, 2018: European Radiology
https://www.readbyqxmd.com/read/29624149/detection-rates-and-sites-of-unruptured-intracranial-aneurysms-according-to-sex-and-age-an-analysis-of-mr-angiography-based-brain-examinations-of-4070-healthy-japanese-adults
#8
Yohichi Imaizumi, Tohru Mizutani, Katsuyoshi Shimizu, Yosuke Sato, Junichi Taguchi
OBJECTIVE The purpose of this study was to evaluate the detection rate and occurrence site according to patient sex and age of unruptured intracranial aneurysms detected through MRI and MR angiography (MRA). METHODS A total of 4070 healthy adults 22 years or older (mean age [± SD] 50.6 ± 11.0 years; 41.9% women) who underwent a brain examination known as "Brain Dock" in the central Tokyo area between April 2014 and March 2015 were checked for unruptured saccular aneurysm using 3-T MRI/MRA. The following types of cases were excluded: 1) protrusions with a maximum diameter < 2 mm at locations other than arterial bifurcations, 2) conical protrusions at arterial bifurcations with a diameter < 3 mm, and 3) cases of suspected aneurysms with unclear imaging of the involved artery...
April 6, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29620511/gray-matter-volume-changes-over-the-whole-brain-in-the-bulbar-and-spinal-onset-amyotrophic-lateral-sclerosis-a-voxel-based-morphometry-study
#9
Zhi-Ye Chen, Meng-Qi Liu, Lin Ma
Objective To investigate cerebral structural signatures of the bulbar- and spinal-onset amyotrophic lateral sclerosis (ALS) using voxel-based morphometry on magnetic resonance imaging. Methods The MR structural images of the brain were obtained from 65 ALS patients (15 bulbar-onset, 50 spinal-onset) and 65 normal controls (NC) on a 3.0T MRI system. Gray matter (GM) volume changes were investigated by voxel-based morphometry, and the distribution of the brain regions with volume changes was compared between ALS and normal controls, as well as between bulbar-onset and spinal-onset ALS based on Neuromorphometrics atlas...
March 30, 2018: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/29615062/kars-related-diseases-progressive-leukoencephalopathy-with-brainstem-and-spinal-cord-calcifications-as-new-phenotype-and-a-review-of-literature
#10
Anna Ardissone, Davide Tonduti, Andrea Legati, Eleonora Lamantea, Rita Barone, Imen Dorboz, Odile Boespflug-Tanguy, Gabriella Nebbia, Marco Maggioni, Barbara Garavaglia, Isabella Moroni, Laura Farina, Anna Pichiecchio, Simona Orcesi, Luisa Chiapparini, Daniele Ghezzi
BACKGROUND: KARS encodes lysyl- transfer ribonucleic acid (tRNA) synthetase, which catalyzes the aminoacylation of tRNA-Lys in the cytoplasm and mitochondria. Eleven families/sporadic patients and 16 different mutations in KARS have been reported to date. The associated clinical phenotype is heterogeneous ranging from early onset encephalopathy to isolated peripheral neuropathy or nonsyndromic hearing impairment. Recently additional presentations including leukoencephalopathy as predominant cerebral involvement or cardiomyopathy, isolated or associated with muscular and cerebral involvement, have been reported...
April 4, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29611451/permeability-imaging-as-a-predictor-of-delayed-cerebral-ischemia-after-aneurysmal-subarachnoid-hemorrhage
#11
Jonathan J Russin, Axel Montagne, Francesco D'Amore, Shuhan He, Mark S Shiroishi, Robert C Rennert, Jena Depetris, Berislav V Zlokovic, William J Mack
Blood-brain barrier (BBB) dysfunction has been implicated in ischemic risk following aneurysmal subarachnoid hemorrhage (aSAH), but never directly imaged. We prospectively examined whether post-bleed day 4 dynamic contrast-enhanced magnetic resonance (DCE-MR) BBB permeability imaging could predict development of delayed cerebral ischemia (DCI). Global MR-derived BBB permeability ( Ktrans ) was significantly higher in aSAH patients who subsequently developed DCI (five patients; 2.28 ± 0.09 × 10-3 min-1 ) compared to those who experienced radiographic vasospasm only (three patients; 1...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29610036/paradoxical-association-of-symptomatic-local-vasogenic-edema-with-global-cerebral-hypoperfusion-after-direct-revascularization-surgery-for-adult-moyamoya-disease
#12
Ryosuke Tashiro, Miki Fujimura, Shunji Mugikura, Kuniyasu Niizuma, Hidenori Endo, Toshiki Endo, Teiji Tominaga
BACKGROUND: Superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis is the standard treatment for Moyamoya disease (MMD). Cerebral hyperperfusion syndrome is a potential complication of this procedure and can cause local vasogenic edema and/or delayed intracerebral hemorrhage. Cerebral hypoperfusion is a contradictory postoperative pathophysiological condition implicated in MMD, but its association with symptomatic local vasogenic edema has not been reported. CASE REPORT: A 31-year-old woman with MMD underwent left STA-MCA anastomosis 3 months after a minor completed stroke in bilateral hemispheres...
March 30, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29605289/magnetic-resonance-imaging-markers-of-cerebral-small-vessel-disease-in-hematoma-expansion-of-intracerebral-hemorrhage
#13
Yue Suo, Weiqi Chen, Yuesong Pan, Yujing Peng, Hongyi Yan, Wei Li, Gaifen Liu, Yongjun Wang
BACKGROUND: Hematoma expansion is an independent risk factor of unfavorable outcome after intracerebral hemorrhage (ICH), which always occurs in the early phase after symptoms onset. The relationship between underlying small vessel disease (SVD) and hematoma expansion was inconsistent in patients with ICH. We aimed to investigate the relationship between magnetic resonance (MR) characteristics of SVD and hematoma expansion in patients with ICH within 72 hours after symptoms onset. METHODS: Data were derived from a cohort of biological sample collection from April 2014 to April 2016...
March 28, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29603826/seed-point-discontinuity-based-segmentation-method-for-the-substantia-nigra-and-the-red-nucleus-in-quantitative-susceptibility-maps
#14
Tian Guo, Yang Song, Jianqi Li, Mingxia Fan, Xu Yan, Andi He, Dongya Huang, Chaomin Shen, Guixu Zhang, Guang Yang
BACKGROUND: The automatic segmentation of cerebral nuclei in the quantitative susceptibility mapping (QSM) images can provide assistance for surgical treatment and pathological mechanism studies. However, as the most frequently used segmentation method, the atlas method provides unsatisfactory results when segmenting the substantia nigra (SN) and the red nucleus (RN). PURPOSE: To propose and evaluate an improved automatic method based on seed points-discontinuity for segmentations of the SN and the RN in QSM images...
March 31, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29600890/preoperative-brain-temperature-imaging-on-proton-magnetic-resonance-spectroscopy-predicts-hemispheric-ischemia-during-carotid-endarterectomy-for-unilateral-carotid-stenosis-with-inadequate-collateral-blood-flow
#15
Shouta Tsutsui, Takamasa Nanba, Yoshichika Yoshioka, Makoto Sasaki, Shunrou Fujiwara, Masakazu Kobayashi, Kenji Yoshida, Kenya Miyoshi, Shinpei Sato, Kuniaki Ogasawara
Objective Preoperative magnetic resonance (MR) angiography sometimes shows the absence of collateral flow via the circle of Willis. This study examined whether brain temperature (BT) imaging on multi-voxel proton MR spectroscopy after this finding increases the accuracy of predicting hemispheric ischemia during internal carotid artery (ICA) clamping during endarterectomy for patients with symptomatic unilateral carotid stenosis. Methods In 52 patients with ICA stenosis (≥70%) and absence of collateral blood flow via the circle of Willis on preoperative MR angiography, BT imaging was displayed using proton multi-voxel MR spectroscopy...
March 30, 2018: Neurological Research
https://www.readbyqxmd.com/read/29588064/the-evaluation-of-the-effects-of-steroid-treatment-on-the-tumor-and-peritumoral-edema-by-dwi-and-mr-spectroscopy-in-brain-tumors
#16
Cahit Kural, Gokce Kaan Atac, Ozkan Tehli, Ilker Solmaz, Caglar Temiz, Irgen Hodaj, Yusuf Izci
OBJECTIVE: To investigate the effects of dexamethasone on brain tumor and peritumoral edema by different sequences of magnetic resonance imaging (MRI). MATERIALS AND METHODS: MRI was performed in 28 patients with brain tumor. Patients were divided into the 3 groups based on the histological diagnosis; Group I: high-grade glial tumor, Group II: low-grade glial tumor, and Group III: brain metastasis. The measurements of peritumoral edema volume and apparent diffusion coefficient (ADC) values were performed while the peak areas of cerebral metabolites were measured by spectroscopy in groups I and II...
March 13, 2018: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29582945/-spontaneous-parenchymal-intracranial-hemorrhage-a-diagnostic-challenge
#17
Ruth Eliahou, Auriel Eitan, Moshe Gomori, Jacob Sosna, Asaf Honig
Non-traumatic intracranial hemorrhage (ICH) is a devastating event associated with a high rate of morbidity and mortality. Patient age, hemorrhage location, number of foci, and underlying diseases are important clues to the etiology. Non-contrast head CT, given its availability and high sensitivity in detecting blood products, is frequently the first tool to readily detect ICH; however, different types of hemorrhages may share a common appearance on CT and the optimal therapeutic approach varies depending on etiology...
March 2018: Harefuah
https://www.readbyqxmd.com/read/29572626/is-visual-activation-associated-with-changes-in-cerebral-high-energy-phosphate-levels
#18
Bart L van de Bank, Marnix C Maas, Lauren J Bains, Arend Heerschap, Tom W J Scheenen
Phosphorus magnetic resonance spectroscopy (31 P MRS) has been employed before to assess phosphocreatine (PCr) and other high-energy phosphates in the visual cortex during visual stimulation with inconsistent results. We performed functional31 P MRS imaging in the visual cortex and control regions during a visual stimulation paradigm at an unprecedented sensitivity, exploiting a dedicated RF coil design at a 7 T MR system. Visual stimulation in a 3 min 24 s on-off paradigm in eight young healthy adults generated a clear BOLD effect with traditional1 H functional MRI in the visual cortex (average z score 9...
March 23, 2018: Brain Structure & Function
https://www.readbyqxmd.com/read/29567656/cerebellar-growth-impairment-characterizes-school-aged-children-born-preterm-without-perinatal-brain-lesions
#19
K Pieterman, T J White, G E van den Bosch, W J Niessen, I K M Reiss, D Tibboel, F E Hoebeek, J Dudink
BACKGROUND AND PURPOSE: Infants born preterm are commonly diagnosed with structural brain lesions known to affect long-term neurodevelopment negatively. Yet, the effects of preterm birth on brain development in the absence of intracranial lesions remain to be studied in detail. In this study, we aim to quantify long term consequences of preterm birth on brain development in this specific group. MATERIALS AND METHODS: Neonatal cranial sonography and follow-up T1-weighted MR imaging and DTI were performed to evaluate whether the anatomic characteristics of the cerebrum and cerebellum in a cohort of school-aged children (6-12 years of age) were related to gestational age at birth in children free of brain lesions in the perinatal period...
March 22, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29567503/transcriptomic-characterization-of-mri-contrast-with-focus-on-the-t1-w-t2-w-ratio-in-the-cerebral-cortex
#20
Jacob Ritchie, Spiro P Pantazatos, Leon French
Magnetic resonance (MR) images of the brain are of immense clinical and research utility. At the atomic and subatomic levels, the sources of MR signals are well understood. However, we lack a comprehensive understanding of the macromolecular correlates of MR signal contrast. To address this gap, we used genome-wide measurements to correlate gene expression with MR signal intensity across the cerebral cortex in the Allen Human Brain Atlas (AHBA). We focused on the ratio of T1-weighted and T2-weighted intensities (T1-w/T2-w ratio image) which is considered to be a useful proxy for myelin content...
March 19, 2018: NeuroImage
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