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MR and Cerebral

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https://www.readbyqxmd.com/read/29046469/-a-rare-case-of-ruptured-unruptured-miniature-aneurysms-originating-from-the-infundibular-dilatation-of-the-callosomarginal-artery-branching-from-the-infracallosal-a2-segment-of-the-azygos-anterior-cerebral-artery
#1
Shota Yoshimura, Chika Somagawa, Kei Satoh, Yutaka Fukuda, Takeshi Hiu, Tomonori Ono, Ryujiro Ushijima, Keisuke Toda, Keisuke Tsutsumi
We report the first case of two de novo miniature aneurysms(ruptured/unruptured)emerging from the infundibular dilatation(ID)of the callosomarginal artery, which branches from the infracallosal(A2)segment of the azygos anterior cerebral artery(AACA), in a 36-year-old woman. The patient had previously been diagnosed with a miniature, unruptured aneurysm, occurring in the A2 segment of the AACA, detected by CT angiography(CTA)at another hospital two years ago, and had been followed up with MR angiography(MRA)every 6 months...
October 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/29044753/development-of-a-quantitative-intracranial-vascular-features-extraction-tool-on-3d-mra-using-semiautomated-open-curve-active-contour-vessel-tracing
#2
Li Chen, Mahmud Mossa-Basha, Niranjan Balu, Gador Canton, Jie Sun, Kristi Pimentel, Thomas S Hatsukami, Jenq-Neng Hwang, Chun Yuan
PURPOSE: To develop a quantitative intracranial artery measurement technique to extract comprehensive artery features from time-of-flight MR angiography (MRA). METHODS: By semiautomatically tracing arteries based on an open-curve active contour model in a graphical user interface, 12 basic morphometric features and 16 basic intensity features for each artery were identified. Arteries were then classified as one of 24 types using prediction from a probability model...
October 17, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29044603/comorbid-masticatory-impairment-delays-recovery-from-acute-cerebral-ischemia-and-locomotor-hypoactivity-after-subarachnoid-hemorrhage-in-mice
#3
Ikuho Kojima, Tatsushi Mutoh, Kazumasu Sasaki, Yasuko Tatewaki, Yasuyuki Taki, Tatsuya Ishikawa
Tooth loss and related changes in the functionality may lead to worse outcome of stroke patients, but the link involved in this pathway remains unclear. This study aimed to determine the effect of comorbid masticatory impairment on acute cerebral ischemia and neurobehavioral outcome after experimental subarachnoid hemorrhage (SAH). Thirty C57BL/6 mice with (molar-less) or without (control) prior treatment of cutting off the upper molars (separated by at least one week), were subjected to SAH by endovascular perforation...
October 17, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29043908/early-functional-connectome-integrity-and-1-year-recovery-in-comatose-survivors-of-cardiac-arrest
#4
Haris I Sair, Yousef Hannawi, Shanshan Li, Joshua Kornbluth, Athena Demertzi, Carol Di Perri, Russell Chabanne, Betty Jean, Habib Benali, Vincent Perlbarg, James Pekar, Charles-Edouard Luyt, Damien Galanaud, Lionel Velly, Louis Puybasset, Steven Laureys, Brian Caffo, Robert D Stevens
Purpose To assess whether early brain functional connectivity is associated with functional recovery 1 year after cardiac arrest (CA). Materials and Methods Enrolled in this prospective multicenter cohort were 46 patients who were comatose after CA. Principal outcome was cerebral performance category at 12 months, with favorable outcome (FO) defined as cerebral performance category 1 or 2. All participants underwent multiparametric structural and functional magnetic resonance (MR) imaging less than 4 weeks after CA...
October 18, 2017: Radiology
https://www.readbyqxmd.com/read/29032219/emergency-extracranial-intracranial-bypass-to-revascularize-salvageable-brain-tissue-in-acute-ischemic-stroke-patients
#5
Jan-Karl Burkhardt, Sebastian Winklhofer, Jorn Fierstra, Susanne Wegener, Giuseppe Esposito, Andreas Luft, Oliver Bozinov, Luca Regli
INTRODUCTION: To present an algorithm based on clinical and radiological factors including MR perfusion/diffusion mismatch (MR-PDM) for the indication of urgent cerebral bypass in patients with acute ischemic stroke METHODS: Analysis of clinical and radiological data on eight consecutive patients undergoing urgent cerebral revascularization for acute ischemic stroke due to occlusion of the internal carotid or middle cerebral artery between 2012 and 2015. All patients were either not eligible or failed first line treatment with emergent endovascular revascularization...
October 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29027841/diffusion-tensor-tractography-in-cerebral-small-vessel-disease-correlation-with-cognitive-function
#6
Maria M D'Souza, S P Gorthi, Kunal Vadwala, Richa Trivedi, C Vijayakumar, Prabhjot Kaur, Subash Khushu
Background Patients with cerebral small vessel disease may suffer from varying levels of cognitive deficit and may progress on to vascular dementia. The extent of involvement, as seen on conventional magnetic resonance (MR) measures, correlates poorly with the level of cognitive decline. The purpose of this study was to investigate the utility of diffusion tensor imaging (DTI) as a marker for white matter damage in small vessel disease and to assess its correlation with cognitive function. Methods Thirty consecutive patients with cerebral small vessel disease underwent conventional MR imaging, DTI, and neuropsychological assessment...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/29019892/bright-sinus-appearance-on-arterial-spin-labeling-mr-imaging-aids-to-identify-cerebral-venous-thrombosis
#7
Ji Hee Kang, Tae Jin Yun, Roh-Eul Yoo, Byung-Woo Yoon, A Leum Lee, Koung Mi Kang, Seung Hong Choi, Ji-Hoon Kim, Chul-Ho Sohn, Moon Hee Han
Cerebral venous thrombosis is a potentially lethal disease. Early diagnosis is essential to improve its prognosis. However, its early diagnosis based on conventional imaging modalities remains a challenge in clinical settings. The purpose of this study was to evaluate whether bright sinus appearance on arterial spin-labeling perfusion-weighted image (ASL-PWI) could help identify cerebral venous thrombosis.ASL-PWI of 13 patients who were confirmed as cerebral venous thrombosis based on neurologic symptoms and computed tomography (CT) or magnetic resonance (MR) venography (with/without cerebral angiography) were retrospectively analyzed for the presence or absence of the following: bright signal in dural sinus termed "bright sinus appearance"; and hypoperfusion in brain parenchyma drained by thrombosed sinus...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28994833/the-efficacy-and-safety-of-endovascular-recanalization-of-occluded-large-cerebral-arteries-during-the-subacute-phase-of-cerebral-infarction-a-case-series-report
#8
Kangning Chen, Xianhua Hou, Zhenhua Zhou, Guangjian Li, Qu Liu, Li Gui, Jun Hu, Shugui Shi
BACKGROUND: Intravenous tissue plasminogen activator with or without mechanical thrombectomy during the acute phase are approved therapies for ischaemic stroke. Due to the short treatment time window (<6 hours) and often treatment failure, these patients would still have an intracranial arterial occlusion (IAO). It is unclear whether these patients can benefit from subsequent interventional recanalizationof their occluded artery in the subacute phase. In this retrospective study, we have examined the efficacy and safety in patients who have received either percutaneous transluminal angioplasty (PTA) or percutaneous transluminal angioplasty and stenting (PTAS) for IAO in the subacute phase of their stroke...
September 2017: Stroke and Vascular Neurology
https://www.readbyqxmd.com/read/28993442/in-room-assessment-of-intravascular-velocity-from-time-resolved-rotational-angiography-in-patients-with-arteriovenous-malformation-a-pilot-study
#9
Chung Jung Lin, Huai Che Yang, Ai Chi Chien, Wan Yuo Guo, Chih Chun Wu, Sheng Che Hung, Ko Kung Chen, Hsiu Mei Wu, Chao Bao Luo, Wei Fa Chu, Jia Sheng Hong, Chun Shien Frank Wu
BACKGROUND: Time-resolved rotational angiography (t-RA) enables interventionists to better comprehend complex arteriovenous malformations (AVMs), thereby facilitating endovascular treatment. However, its use in evaluating hemodynamic changes has rarely been explored. OBJECTIVE: This study uses t-RA to estimate intravascular flow in patients with AVM to compare this with flow in the normal population. METHODS: Patients with available t-RA scans were prospectively categorized into one of three groups: hemorrhagic AVM, non-hemorrhagic AVM and control...
October 9, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28987841/severe-subarachnoid-hemorrhage-due-to-a-fusiform-lateral-anterior-a1-artery-perforator-aneurysm-with-spontaneous-resolution
#10
Gökce Hatipoglu Majernik, Elvis J Hermann, Christian Hartmann, Peter Raab, Joachim K Krauss
Perforating arteries are thin and long vessels which originate from the main cerebral arteries. Subarachnoidal hemorrhage from a perforator aneurysm is rare. Here, we report on a 70-year-old woman who presented with severe subarachnoid hemorrhage from a fusiform lateral anterior (A1) artery perforator aneurysm. Unexpectedly, digital subtraction angiography was non-diagnostic. MR imaging, however, demonstrated occlusion of the aneurysm secondary to thrombosis. Surgery was performed to remove the associated hematoma, and histopathological examination verified intraaneurysmal thrombosis...
October 5, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28987682/mr-diffusion-kurtosis-imaging-predicts-malignant-potential-and-the-histological-type-of-meningioma
#11
Fen Xing, Ning Tu, Tong San Koh, Guangyao Wu
PURPOSE: To explore the value of Diffusion kurtosis imaging (DKI) metrics in the differential diagnosis of meningioma. METHODS: For this study, we retrospectively enrolled 35 patients of cerebral meningioma with DKI which included axial diffusion coefficient (AD), radial diffusion coefficient (RD), mean diffusion coefficient (MD), fractional anisotropy (FA), axial kurtosis (AK), radial kurtosis (RK) and mean kurtosis (MK). All of these metrics were normalized according to contralateral normal-appearing white matter (NAWMc)...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28987665/altered-spontaneous-brain-activity-pattern-in-cognitively-normal-young-adults-carrying-mutations-of-app-presenilin-1-2-and-apoe-%C3%AE%C2%B54
#12
Li Juan Zheng, Yun Yan Su, Yun Fei Wang, Jianhui Zhong, Xue Liang, Gang Zheng, Guang Ming Lu, Long Jiang Zhang
OBJECTIVE: To explore genetic effects of amyloid precursor protein (APP), presenilin-1/2 and apolipoprotein E (APOE) ε4 on brain structural and functional alterations in cognitively normal young adults. MATERIALS AND METHODS: Eighty healthy adults (mean age 24.0±2.5years; n=18, APP/presenilin-1/2 group; n=31, APOE ε4 group; n=31, control group [without above-mentioned gene mutation]) underwent high-resolution T1-weighted 3D anatomical imaging, resting-state functional MR imaging and neuropsychological assessments...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28984142/visual-inspection-of-mr-relative-cerebral-blood-volume-maps-has-limited-value-for-distinguishing-progression-from-pseudoprogression-in-glioblastoma-multiforme-patients
#13
Melissa Kerkhof, Pauline L Tans, Rogier E Hagenbeek, Geert J Lycklama À Nijeholt, Finn K Holla, Tjeerd J Postma, Chiara S Straathof, Linda Dirven, Martin Jb Taphoorn, Maaike J Vos
AIM: We examined whether visual interpretation of relative cerebral blood volume (rCBV) color maps made with dynamic susceptibility-weighted perfusion MRI can reliably distinguish progressive disease (PD) from pseudoprogression (PsPD) in glioblastoma patients during treatment with temozolomide chemoradiation. MATERIALS & METHODS: Magnetic resonance (MR) perfusion-weighted images were evaluated based on visual inspection of rCBV maps. Sensitivity and specificity were calculated to assess if rCBV can reliably differentiate between PD and PsPD, during standard chemoradiation therapy...
October 6, 2017: CNS Oncology
https://www.readbyqxmd.com/read/28982786/preoperative-cerebral-oxygen-extraction-fraction-imaging-generated-from-7t-mr-quantitative-susceptibility-mapping-predicts-development-of-cerebral-hyperperfusion-following-carotid-endarterectomy
#14
J-I Nomura, I Uwano, M Sasaki, K Kudo, F Yamashita, K Ito, S Fujiwara, M Kobayashi, K Ogasawara
BACKGROUND AND PURPOSE: Preoperative hemodynamic impairment in the affected cerebral hemisphere is associated with the development of cerebral hyperperfusion following carotid endarterectomy. Cerebral oxygen extraction fraction images generated from 7T MR quantitative susceptibility mapping correlate with oxygen extraction fraction images on positron-emission tomography. The present study aimed to determine whether preoperative oxygen extraction fraction imaging generated from 7T MR quantitative susceptibility mapping could identify patients at risk for cerebral hyperperfusion following carotid endarterectomy...
October 5, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28982392/lymphomatosis-cerebri-a-rare-variant-of-primary-central-nervous-system-lymphoma-and-mr-imaging-features
#15
Hui Yu, Bo Gao, Jing Liu, Yong-Cheng Yu, Mark S Shiroishi, Ming-Ming Huang, Wen-Xiu Yang, Zhi-Zhong Guan
BACKGROUND: Lymphomatosis cerebri (LC) is a rare variant of primary central nervous system lymphoma (PCNSL), characterized by diffuse infiltration without the formation of a discrete mass. The diagnosis of LC is a challenge because the imaging findings are atypical for lymphoma. The purpose of present study is to investigate MRI characteristics and clinical features of LC and potentially facilitate an early and accurate diagnosis of this often-missed disease. METHODS: Seven patients (average 44 years, 19-58 years) with LC proved basing on MRI and histology were retrospectively reviewed the clinical data and cerebral MR imaging findings...
October 5, 2017: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/28982332/asymmetric-cerebrovascular-collateral-supply-affects-cognition-in-patients-with-unilateral-carotid-artery-stenosis
#16
Kuo-Lun Huang, Ting-Yu Chang, Chien-Hung Chang, Ho-Ling Liu, Yeu-Jhy Chang, Chi-Hung Liu, Ho-Fai Wong, Yi-Ming Wu, Tsong-Hai Lee, Meng-Yang Ho
BACKGROUND: The time to maximum of the residue function (TMax) has been employed to identify the penumbra in acute ischemic stroke. Cognitive impairment in patients with carotid artery stenosis (CAS) has been attributed to chronic cerebral hypoperfusion. The study aimed to examine whether cognitive impairment can be detected based on a preliminary TMax cutoff in patients with unilateral CAS. METHODS: Fifty unilateral CAS patients underwent dynamic susceptibility contrast MR perfusion...
October 5, 2017: Current Neurovascular Research
https://www.readbyqxmd.com/read/28974571/endothelial-mineralocorticoid-receptor-mediates-parenchymal-arteriole-and-posterior-cerebral-artery-remodeling-during-angiotensin-ii-induced-hypertension
#17
Janice M Diaz-Otero, Courtney Fisher, Kelsey Downs, M Elizabeth Moss, Iris Z Jaffe, William F Jackson, Anne M Dorrance
The brain is highly susceptible to injury caused by hypertension because the increased blood pressure causes artery remodeling that can limit cerebral perfusion. Mineralocorticoid receptor (MR) antagonism prevents hypertensive cerebral artery remodeling, but the vascular cell types involved have not been defined. In the periphery, the endothelial MR mediates hypertension-induced vascular injury, but cerebral and peripheral arteries are anatomically distinct; thus, these findings cannot be extrapolated to the brain...
October 3, 2017: Hypertension
https://www.readbyqxmd.com/read/28972127/functional-characterization-of-5-ht1b-receptor-drugs-in-non-human-primates-using-simultaneous-pet-mr
#18
Hanne D Hansen, Joseph B Mandeville, Christin Y Sander, Jacob M Hooker, Ciprian Catana, Bruce R Rosen, Gitte M Knudsen
In the present study, we used a simultaneous PET-MR experimental design to investigate the effects of functionally different compounds (agonist, partial agonist and antagonist) on 5-HT1B receptor (5-HT1BR) occupancy and the associated hemodynamic responses. In anaesthetized male non-human primates (NHP, n=3), we used PET imaging with the radioligand [(11)C]AZ10419369 administered as a bolus followed by constant infusion to measure changes in 5-HT1BR occupancy. Simultaneously, we measured changes in cerebral blood volume (CBV) as a proxy of drug effects on neuronal activity...
October 2, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28970078/evaluation-of-cerebral-arterial-and-venous-system-in-tuberculous-meningitis
#19
Jayantee Kalita, Rajesh K Singh, Usha K Misra, Sunil Kumar
BACKGROUND: Central nervous system infection especially pyogenic results in cerebral venous sinus thrombosis. Tuberculous meningitis (TBM) although associated with infarctions but there is no comprehensive study evaluating the role of CVST contributing in infarction. PURPOSE: To evaluate cerebral arterial and venous system using MR angiography (MRA) and MR venography (MRV) in TBM, and correlate with clinical and MRI findings. MATERIALS AND METHODS: Consecutive patients with TBM were evaluated clinically and their consciousness was assessed by using Glasgow Coma scale...
September 29, 2017: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/28966828/sequential-changes-of-arterial-spin-labeling-perfusion-mr-images-with-dual-postlabeling-delay-following-reconstructive-surgery-for-giant-internal-carotid-artery-aneurysm
#20
Takafumi Shimogawa, Takato Morioka, Tomoaki Akiyama, Sei Haga, Shuji Arakawa, Tetsuro Sayama
BACKGROUND: Arterial spin-labeling magnetic resonance perfusion imaging (ASL-MRI) allows noninvasive measurement of cerebral blood flow (CBF) but depends on arterial transit time (ATT). To overcome this problem, we developed a simple ASL technique with dual postlabeling delay (PLD) settings. In addition to the routinely used PLD of 1.5 seconds, we selected another PLD of 2.5 seconds to assess slowly streaming blood flow and detect arterial transit artifacts (ATAs) resulting from stagnant intravascular magnetically labeled spins...
2017: Surgical Neurology International
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