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https://www.readbyqxmd.com/read/28525363/targeted-sequencing-of-tonsillar-and-base-of-tongue-cancer-and-human-papillomavirus-positive-unknown-primary-of-the-head-and-neck-reveals-prognostic-effects-of-mutated-fgfr3
#1
Cinzia Bersani, Lars Sivars, Linnea Haeggblom, Sebastian DiLorenzo, Michael Mints, Andreas Ährlund-Richter, Nikolaos Tertipis, Eva Munck-Wikland, Anders Näsman, Torbjörn Ramqvist, Tina Dalianis
BACKGROUND: Human papillomavirus positive (HPV+) tonsillar cancer (TSCC), base of tongue cancer (BOTSCC) and unknown primary cancer of the head and neck (HNCUP) have better outcome than corresponding HPV- cancers. To find predictive markers for response to treatment, and correlations and differences in mutated oncogenes and suppressor genes between HPV+ TSCC/BOTSSCC and HPV+ HNCUP and HPV- TSCC/BOTSCC targeted next-generation sequencing was performed of frequently mutated regions in 50 cancer related genes...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28478788/on-scene-and-final-assessments-and-their-interrelationship-among-patients-who-use-the-ems-on-multiple-occasions
#2
Julia Tärnqvist, Erik Dahlén, Gabriella Norberg, Carl Magnusson, Johan Herlitz, Anneli Strömsöe, Christer Axelsson, Magnus Andersson Hagiwara
Introduction The use of Emergency Medical Services (EMS) is increasing. A number of patients call repeatedly for EMS. Early studies of frequent callers show that they form a heterogenous group. Problem There is a lack of research on frequent EMS callers. There is furthermore a lack of knowledge about characteristics and the prehospital assessment of the patients who call for EMS on several occasions. Finally, there is a general lack of knowledge with regard to the association between the prehospital assessment by health care providers and the final diagnosis...
May 8, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28468558/expanding-suicide-crisis-services-to-text-and-chat
#3
Zachary Predmore, Rajeev Ramchand, Lynsay Ayer, Virginia Kotzias, Charles Engel, Patricia Ebener, Janet E Kemp, Elizabeth Karras, Gretchen L Haas
BACKGROUND: Crisis support services have historically been offered by phone-based suicide prevention hotlines, but are increasingly becoming available through alternative modalities, including Internet chat and text messaging. AIMS: To better understand differences in the use of phone and chat/text services. METHOD: We conducted semistructured interviews with call responders at the Veterans Crisis Line who utilize multimodal methods to respond to veterans in crisis...
May 3, 2017: Crisis
https://www.readbyqxmd.com/read/28365587/electronic-nicotine-delivery-system-ends-use-during-smoking-cessation-a-qualitative-study-of-40-oklahoma-quitline-callers
#4
Katrina A Vickerman, Laura A Beebe, Gillian L Schauer, Brooke Magnusson, Brian A King
OBJECTIVES: Approximately 10% (40 000) of US quitline enrollees who smoke cigarettes report current use of electronic nicotine delivery systems (ENDS); however, little is known about callers' ENDS use. Our aim was to describe why and how quitline callers use ENDS, their beliefs about ENDS and the impact of ENDS use on callers' quit processes and use of FDA-approved cessation medications. DESIGN: Qualitative interviews conducted 1-month postregistration. Interviews were recorded, transcribed, double-coded and analysed to identify themes...
April 1, 2017: BMJ Open
https://www.readbyqxmd.com/read/28288619/medication-related-calls-received-by-a-national-telenursing-triage-and-advice-service-in-australia-a-retrospective-cohort-study
#5
Ling Li, Rebecca Lake, Magdalena Z Raban, Mary Byrne, Maureen Robinson, Johanna Westbrook, Melissa T Baysari
BACKGROUND: Telenursing triage and advice services are increasingly being used to deliver health advice. Medication-related queries are common, however little research has explored the medication-related calls made to these services. The aim of this study was to examine the profile of medication-related calls to a national telenursing triage and advice service and the medications involved. METHODS: This was a retrospective cohort study of medication-related calls received by Australia's national helpline (healthdirect helpline) in 2014, which provides free advice from registered nurses...
March 14, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28241736/bbcanalyzer-a-visual-approach-to-facilitate-variant-calling
#6
Sarah Sandmann, Aniek O de Graaf, Martin Dugas
BACKGROUND: Deriving valid variant calling results from raw next-generation sequencing data is a particularly challenging task, especially with respect to clinical diagnostics and personalized medicine. However, when using classic variant calling software, the user usually obtains nothing more than a list of variants that pass the corresponding caller's internal filters. Any expected mutations (e.g. hotspot mutations), that have not been called by the software, need to be investigated manually...
February 28, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28219730/one-plus-one-binary-alarm-calls-retain-individual-signature-for-longer-periods-than-single-note-alarms-in-the-european-ground-squirrel-spermophilus-citellus
#7
Irena Schneiderová, Elena V Volodina, Vera A Matrosova, Ilya A Volodin
Ground squirrels emit species-specific alarm calls that, among other characteristics, differ by the number of elements. Unlike some species that produce single-element calls, e.g., the Speckled ground squirrel (Spermophilus suslicus), individual European ground squirrels (S. citellus) frequently emit binary-element calls in addition to single-element calls. We tested the hypothesis that the time stability of individuality encoded in alarm calls might be better retained by complicating their acoustic structure by adding extra elements...
May 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28137276/towards-standardization-of-next-generation-sequencing-of-ffpe-samples-for-clinical-oncology-intrinsic-obstacles-and-possible-solutions
#8
Maxim Ivanov, Konstantin Laktionov, Valery Breder, Polina Chernenko, Ekaterina Novikova, Ekaterina Telysheva, Sergey Musienko, Ancha Baranova, Vladislav Mileyko
BACKGROUND: Next generation sequencing has a potential to revolutionize the management of cancer patients within the framework of precision oncology. Nevertheless, lack of standardization decelerated entering of the technology into the clinical testing space. Here we dissected a number of common problems of NGS diagnostics in oncology and introduced ways they can be resolved. METHODS: DNA was extracted from 26 formalin fixed paraffin embedded (FFPE) specimens and processed with the TrueSeq Amplicon Cancer Panel (Illumina Inc, San Diego, California) targeting 48 cancer-related genes and sequenced in single run...
January 31, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28122372/environmental-and-occupational-exposures-and-amyotrophic-lateral-sclerosis-in-new-england
#9
Angeline S Andrew, Tracie A Caller, Rup Tandan, Eric J Duell, Patricia L Henegan, Nicholas C Field, Walter G Bradley, Elijah W Stommel
BACKGROUND: Recent data provide support for the concept that potentially modifiable exposures are responsible for sporadic amyotrophic lateral sclerosis (ALS). OBJECTIVE: To evaluate environmental and occupational exposures as risk factors for sporadic ALS. METHODS: We performed a case-control study of ALS among residents of New England, USA. The analysis compared questionnaire responses from 295 patients with a confirmed ALS diagnosis to those of 225 controls without neurodegenerative illness...
2017: Neuro-degenerative Diseases
https://www.readbyqxmd.com/read/27940763/childhood-victims-of-snakebites-2000-2013
#10
Joann Schulte, Kristina Domanski, Eric Anthony Smith, Annelle Menendez, Kurt C Kleinschmidt, Brett A Roth
BACKGROUND: Snakebites are not a reportable condition (to state health departments), and 1 major assessment of US children with snakebites was published 50 years ago. Increasing urbanization, population shifts south and west, newer antivenom therapy, and the importation of exotic snakes may have changed snakebites. Poison control centers are often consulted on treatment and collect surveillance data. METHODS: Generic codes for venomous, nonvenomous, and unknown snakebites were used to characterize victims aged ≤18 years reported to US poison control centers between 2000 and 2013...
November 2016: Pediatrics
https://www.readbyqxmd.com/read/27869506/testing-a-model-of-functional-impairment-in-telephone-crisis-support-workers
#11
Taneile A Kitchingman, Coralie J Wilson, Peter Caputi, Ian Wilson, Alan Woodward
BACKGROUND: It is well known that helping professionals experience functional impairment related to elevated symptoms of psychological distress as a result of frequent empathic engagement with distressed others. Whether telephone crisis support workers are impacted in a similar way is not currently reported in the literature. AIMS: The purpose of this study was to test a hypothesized model of factors contributing to functional impairment in telephone crisis support workers...
November 21, 2016: Crisis
https://www.readbyqxmd.com/read/27862572/how-do-frequent-users-of-crisis-helplines-differ-from-other-users-regarding-their-reasons-for-calling-results-from-a-survey-with-callers-to-lifeline-australia-s-national-crisis-helpline-service
#12
Aves Middleton, Alan Woodward, Jane Gunn, Bridget Bassilios, Jane Pirkis
Crisis helplines are designed to provide short-term support to people in an immediate crisis. However, there is a group of users who call crisis helplines frequently over an extended period of time. The reasons for their ongoing use remain unclear. The aim of this study was to investigate the differences in the reasons for calling between frequent and other users of crisis helplines. This was achieved by examining the findings from a brief survey completed by callers to Lifeline Australia at the end of their call between February and July 2015...
May 2017: Health & Social Care in the Community
https://www.readbyqxmd.com/read/27820868/spatio-temporal-dynamics-of-field-cricket-calling-behaviour-implications-for-female-mate-search-and-mate-choice
#13
Diptarup Nandi, Rohini Balakrishnan
Amount of calling activity (calling effort) is a strong determinant of male mating success in species such as orthopterans and anurans that use acoustic communication in the context of mating behaviour. While many studies in crickets have investigated the determinants of calling effort, patterns of variability in male calling effort in natural choruses remain largely unexplored. Within-individual variability in calling activity across multiple nights of calling can influence female mate search and mate choice strategies...
2016: PloS One
https://www.readbyqxmd.com/read/27690289/emergency-medical-dispatchers-can-obtain-accurate-pediatric-weights-from-9-1-1-callers
#14
Todd Chassee, Diann Reischmann, Michael Mancera, John D Hoyle
BACKGROUND: Prehospital pediatric drug dosing errors affect 56,000 U.S. children annually. An accurate weight is the first step in accurate dosing. To date, the accuracy of Emergency Medical Dispatcher (EMD) obtained weights has not been evaluated. We hypothesized that EMD could obtain accurate pediatric weights. METHODS: We used a convenience sample of patients 12 years and younger that were transported by EMS to one children's hospital. EMD obtained patient weight (DW) from the 9-1-1 caller...
November 2016: Prehospital Emergency Care
https://www.readbyqxmd.com/read/27662261/children-s-medicine-what-do-consumers-really-want-to-know
#15
Clara Crunkhorn, Mieke van Driel, Van Nguyen, Treasure McGuire
AIM: This study explored consumer knowledge gaps and concerns regarding medication use in children. METHODS: Calls concerning or made by people under 18 to the pharmacist-operated, national consumer medicines call centre National Prescribing Service Medicines Line (2002 to June 2010) were analysed. Calls were classified and narratively explored by age group: <1, 1-4, 5-14 and 15-17 years. Consumer Medication Information (CMI) and evidence-based resources were examined to determine information concordance for common questions...
September 23, 2016: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/27650484/frequent-callers-in-primary-health-care-a-qualitative-study-with-a-nursing-perspective
#16
Inger K Holmström, Anna Krantz, Lena Karacagil, Annelie J Sundler
AIM: To: (a) describe how telephone nurses define a frequent caller; and (b) describe their experiences with calls from frequent callers to primary healthcare centres. BACKGROUND: Telephone nursing has been noted to be a cost-effective method to enhance access to and use of health care. Some patients use these services extensively and are called 'frequent callers'. Little is known about this group of callers, the reasons behind these calls and telephone nurses' experiences and strategies to manage the calls...
March 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/27629892/non-urgent-emergency-callers-characteristics-and-prognosis
#17
K K Lehm, M S Andersen, I S Riddervold
OBJECTIVE: In Denmark, calls to the Danish emergency number 1-1-2 concerning medical emergencies are received by an emergency medical communication center (EMCC). At the EMCC, health care professionals (nurses, paramedics, and physicians) decide the necessary response, depending on the level of emergency as indicated by the Danish Index for Emergency Care. The index states 37 main criteria (symptoms) and five levels of emergency, descending from A (life threatening) to E (not serious)...
March 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/27582514/identification-and-analysis-of-informative-single-nucleotide-polymorphisms-in-16s-rrna-gene-sequences-of-the-bacillus-cereus-group
#18
Janetta R Hakovirta, Samantha Prezioso, David Hodge, Segaran P Pillai, Linda M Weigel
Analysis of 16S rRNA genes is important for phylogenetic classification of known and novel bacterial genera and species and for detection of uncultivable bacteria. PCR amplification of 16S rRNA genes with universal primers produces a mixture of amplicons from all rRNA operons in the genome, and the sequence data generally yield a consensus sequence. Here we describe valuable data that are missing from consensus sequences, variable effects on sequence data generated from nonidentical 16S rRNA amplicons, and the appearance of data displayed by different software programs...
November 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27573636/communicating-with-participants-during-the-conduct-of-multi-center-clinical-trials
#19
Erika F Augustine, E Ray Dorsey, Robert A Hauser, Jordan J Elm, Barbara C Tilley, Karl K Kieburtz
BACKGROUND: Communicating with trial participants is an important aspect of study conduct, relevant for informed consent and respect for participants. Group teleconferences are one means to convey information to trial participants. We used group teleconferences during an ongoing large-scale clinical trial to communicate important trial updates. METHODS: The National Institute of Neurological Disorders and Stroke Exploratory Trials in Parkinson's Disease Longitudinal Study-1 trial studied creatine for treatment of early-stage Parkinson's disease...
December 2016: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/27562948/augmented-survival-of-out-of-hospital-cardiac-arrest-victims-with-the-use-of-mobile-phones-for-emergency-communication-under-the-da-cpr-protocol-getting-information-from-callers-beside-the-victim
#20
Tetsuo Maeda, Akira Yamashita, Yasuhiro Myojo, Yukihiro Wato, Hideo Inaba
PURPOSE: To investigate the impacts of emergency calls made using mobile phones on the quality of dispatcher-assisted cardiopulmonary resuscitation (DA-CPR) and survival from out-of-hospital cardiac arrests (OHCAs) that were not witnessed by emergency medical service (EMS). METHODS: In this prospective study, we collected data for 2530 DA-CPR-attempted medical emergency cases (517 using mobile phones and 2013 using landline phones) and 2980 non-EMS-witnessed OHCAs (600 using mobile phones and 2380 using landline phones)...
October 2016: Resuscitation
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