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https://www.readbyqxmd.com/read/29034181/inhibitory-effect-of-yokukansan-on-the-decrease-in-the-hippocampal-excitatory-amino-acid-transporter-eaat2-in-stress-maladaptive-mice
#1
Hiroko Miyagishi, Minoru Tsuji, Atsumi Saito, Kazuya Miyagawa, Hiroshi Takeda
Chronic stress is widely recognized as a risk factor for the development of major depression and anxiety disorders. Recently, we reported that yokukansan (YKS), a traditional Japanese herbal medicine, alleviated emotional abnormality in stress-maladaptive mice. The aim of the present study was to examine the effect of YKS on the expression of excitatory amino acid transporter (EAAT) 1-4 in the prefrontal cortex and hippocampus in stress-maladaptive mice. Mice were chronically exposed to inadaptable stress, i...
October 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28979206/cellular-pharmacological-effects-of-the-traditional-japanese-kampo-medicine-yokukansan-on-brain-cells
#2
REVIEW
Kazushige Mizoguchi, Yasushi Ikarashi
Yokukansan (YKS) is a traditional Japanese Kampo medicine currently used for the treatment of the behavioral psychological symptoms associated with dementia (BPSD), which is frequently problematic in neurodegenerative disorders such as Alzheimer's disease. Regarding the pharmacological mechanisms underlying its efficacy, we recently reviewed the multiple effects of YKS on the neurotransmitter systems (e.g., glutamatergic, serotonergic, dopaminergic, cholinergic, GABAergic, and adrenergic neurotransmission) in various brain regions that are related to the psychological, emotional, cognitive, or memory functions...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28961087/the-kampo-medicine-yokukansan-yks-enhances-nerve-growth-factor-ngf-induced-neurite-outgrowth-in-pc12-cells
#3
Kazuki Terada, Yukari Matsushima, Kazuhisa Matsunaga, Jiro Takata, Yoshiharu Karube, Atsushi Ishige, Koji Chiba
Accumulating evidence indicates that neurotrophic factor-like substances involved in the induction of neurotrophic factor synthesis may aid in the treatment of neurological disorders, such as Alzheimer's disease. Yokukansan (YKS), a traditional Kampo medicine, has been used for the treatment of anxiety and mood disorders. In the present study, we analyzed the neurite length of nerve growth factor (NGF)-treated rat pheochromocytoma (PC12) cells via Western blot analysis. Akt and extracellular-regulated kinase 1/2 (ERK1/2) phosphorylation levels were assessed in the presence of YKS and following the treatment with TrkA inhibitor, K252a...
September 28, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28929408/yokukansan-reduces-cuprizone-induced-demyelination-in-the-corpus-callosum-through-anti-inflammatory-effects-on-microglia
#4
Taichi Nomura, Yoshio Bando, Hua You, Tatsuhide Tanaka, Shigetaka Yoshida
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). The release of inflammatory cytokines and pro-oxidant molecules from microglia has been shown to play a key role in the pathology of MS. Thus, suppression of microglial cell activation is an attractive therapeutic option. Yokukansan, a traditional Japanese herbal medicine, has been shown to suppress microglial activity in the CNS. However, whether or not yokukansan reduces demyelination observed in the CNS during MS remains unknown...
September 19, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28855990/randomized-phase-ii-study-of-tj-54-yokukansan-for-postoperative-delirium-in-gastrointestinal-and-lung-malignancy-patients
#5
Nobuhiro Sugano, Toru Aoyama, Tsutomu Sato, Mariko Kamiya, Shinya Amano, Naoto Yamamoto, Takuya Nagashima, Yoshihiro Ishikawa, Katsuhiko Masudo, Masataka Taguri, Takeharu Yamanaka, Yuji Yamamoto, Hiroshi Matsukawa, Ryuji Shiraisi, Takashi Oshima, Norio Yukawa, Yasushi Rino, Munetaka Masuda
The present study evaluated the efficacy and safety of TJ-54 (Yokukansan; a traditional Japanese medicine) for the prevention and/or treatment of postoperative delirium in a randomized phase II trial of patients receiving surgery for gastrointestinal and lung malignancies. Patients ≥70 years of age who underwent surgery for gastrointestinal or lung malignancy were eligible for participation in the study. The 186 eligible patients were randomly assigned at a 1:1 ratio to receive TJ-54 or control during their peri-operative care (between 7 days prior to surgery and 4 days following surgery, except for the operation day)...
October 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28619768/liquorice-induced-hypokalaemia-in-patients-treated-with-yokukansan-preparations-identification-of-the-risk-factors-in-a-retrospective-cohort-study
#6
Saori Shimada, Tetsuaki Arai, Akira Tamaoka, Masato Homma
OBJECTIVE: To evaluate serum potassium levels and rates of hypokalaemia in patients treated with liquorice-containing Japanese traditional Kampo-medicines Yokukansan (YK) and Yokukansan-ka-chinpihange (YKCH). DESIGN: Retrospective cohort study. SETTING: Patients receiving YK preparations for dementia and other psychiatric disorders in the University of Tsukuba Hospital in Japan. PARTICIPANTS: 389 patients (male/female: 174/215, 68...
June 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28591818/yokukansan-for-the-treatment-of-preoperative-anxiety-and-postoperative-delirium-in-colorectal-cancer-patients-a-retrospective-study
#7
Saho Wada, Hironobu Inoguchi, Takatoshi Hirayama, Yutaka J Matsuoka, Yosuke Uchitomi, Hiroki Ochiai, Shunsuke Tsukamoto, Dai Shida, Yukihide Kanemitsu, Ken Shimizu
Background: Yokukansan (YKS), a Japanese traditional herbal medicine for neurosis and insomnia, is speculated to be useful for perioperative psychiatric symptoms in cancer patients, but there exists little empirical evidence. This study provides preliminary data about the efficacy, feasibility, and side effects of YKS for the treatment of preoperative anxiety and postoperative delirium in cancer patients. Methods: We retrospectively reviewed the medical records of colorectal cancer patients who took YKS for preoperative anxiety, evaluating the following: (1) patient characteristics, (2) feasibility of taking YKS, (3) changes in preoperative anxiety based on the Clinical Global Impression (CGI) scale and Edmonton Symptom Assessment System-revised (ESAS-r-anxiety), (4) incidence of postoperative delirium and (5) YKS-related side effects...
September 1, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28491038/yokukansan-and-yokukansankachimpihange-ameliorate-aggressive-behaviors-in-rats-with-cholinergic-degeneration-in-the-nucleus-basalis-of-meynert
#8
Masahiro Tabuchi, Keita Mizuno, Kazushige Mizoguchi, Tomohisa Hattori, Yoshio Kase
Yokukansan (YKS) and yokukansankachimpihange (YKSCH) are traditional Japanese Kampo medicines. The latter comprises YKS along with the medicinal herbs Citrus unshiu peel and Pinellia tuber. Both of these Kampo medicines are indicated for the treatment of night crying and irritability in children and for neurosis and insomnia in adults. In recent clinical trials, YKS exhibited ameliorative effects on the behavioral and psychological symptoms of dementia, such as aggressiveness, excitement, and irritability. In the present study, we aimed to clarify the involvement of cholinergic degeneration in the nucleus basalis of Meynert (NBM) in the development of aggressiveness in rats...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28377723/multiple-psychopharmacological-effects-of-the-traditional-japanese-kampo-medicine-yokukansan-and-the-brain-regions-it-affects
#9
REVIEW
Kazushige Mizoguchi, Yasushi Ikarashi
Yokukansan (YKS), a traditional Japanese Kampo medicine, has indications for use in night crying and irritability in children, as well as neurosis and insomnia. It is currently also used for the remedy of the behavioral and psychological symptoms of dementia (BPSD), such as aggressiveness, agitation, and hallucinations. In parallel with clinical evidence, a significant amount of fundamental researches have been undertaken to clarify the neuropsychopharmacological efficacies of YKS, with approximately 70 articles, including our own, being published to date...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28376888/daily-administration-of-yokukansan-and-keishito-prevents-social-isolation-induced-behavioral-abnormalities-and-down-regulation-of-phosphorylation-of-neuroplasticity-related-signaling-molecules-in-mice
#10
COMPARATIVE STUDY
Hironori Fujiwara, Yaoyu Han, Ken Ebihara, Suresh Awale, Ryota Araki, Takeshi Yabe, Kinzo Matsumoto
BACKGROUND: Our previous studies demonstrated that post-weaning social isolation (ISO) in mice induces behavior abnormalities such as deficits of sociability- and attention-like behaviors. These deficits can be attenuated by methylphenidate (MPH), a drug used for attention deficit hyperactivity disorder (ADHD), suggesting that ISO mice offer a potential animal model of comorbid developmental disorder with ADHD and autism spectrum disorder symptoms. This study investigated the effects of Kampo formulae, yokukansan (YKS) and keishito (KST), on the neuropsychiatric symptoms of ISO mice to clarify the therapeutic or preventive/delaying potential of these formulae for the treatment of neurodevelopmental disorders...
April 4, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28360524/antistress-effects-of-kampo-medicine-yokukansan-via-regulation-of-orexin-secretion
#11
Haruto Katahira, Masataka Sunagawa, Daishi Watanabe, Yasuaki Kanada, Ayami Katayama, Risa Yamauchi, Masashi Takashima, Shintaro Ishikawa, Tadashi Hisamitsu
OBJECTIVE: Various stressors induce stress responses through the hypothalamic-pituitary-adrenal and the sympathetic-adrenal-medullary axes, which are regulated, in part, by orexin. For example, secretion of orexin in the hypothalamus is increased in rats exposed to the stress of social isolation for 1 week. In this study, the antistress effects of Kampo medicine Yokukansan (YKS) via the regulation of orexin secretion were investigated using a rat model. METHODS AND RESULTS: The administration of 300 mg/kg per day of YKS to rats for 1 week significantly decreased the plasma orexin levels compared with non-treated rats, whereas the administration of 1,000 mg/kg of YKS had no effect on orexin levels...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28322152/serotonin-receptor-binding-characteristics-of-geissoschizine-methyl-ether-an-indole-alkaloid-in-uncaria-hook
#12
Yasushi Ikarashi, Kyoji Sekiguchi, Kazushige Mizoguchi
Geissoschizine methyl ether (GM) is one of the indole alkaloids in Uncaria hook, and an active ingredient of yokukansan (YKS) that improves behavioral and psychological symptoms of dementia (BPSD) in patients with several types of dementia. The pharmacological action of GM has been related to various serotonin (5-HT) receptor subtypes. Here we describe previous findings and our own data to review the binding characteristics of GM to the 5-HT receptor subtypes. Competitive receptor-binding assays showed that GM bound the following 5-HT receptor subtypes: 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT4, 5-HT5A, 5-HT6, and 5-HT7...
March 20, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28171868/incidence-and-risk-factors-of-postoperative-delirium-following-pancreatic-surgery-does-the-administration-of-tj-54-reduce-the-incidence-of-delirium
#13
Shugo Mizuno, Sachie Takeuchi, Masashi Kishiwada, Noriko Mizutani, Mikiko Matsuda, Noriko Sekoguchi, Yusuke Iizawa, Yoshinori Azumi, Naohisa Kuriyama, Masanobu Usui, Hiroyuki Sakurai, Kazuo Maruyama, Masahiro Okuda, Motohiro Okada, Shuji Isaji
PURPOSES: To clarify the incidence and risk factors of postoperative delirium in patients following pancreatic surgery, and the impact of yokukansan (TJ-54) administered to reduce delirium. METHODS: Fifty-nine consecutive patients who underwent pancreatic surgery (2012.4-2013.5) were divided into 2 groups: TJ-54 group: patients who received TJ-54 (n = 21) due to insomnia and the No-TJ-54 group: patients who did not receive TJ-54 (n = 38), and the medical records including the delirium rating scale - Japanese version (DRS-J) were retrospectively reviewed...
February 8, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/28053886/yokukansan-enhances-the-proliferation-of-b65-neuroblastoma
#14
Yoshihiko Nakatani, Taku Amano, Hikaru Yamamoto, Norio Sakai, Minoru Tsuji, Hiroshi Takeda
Yokukansan, a traditional Japanese herbal medicine, has been considered to be a novel alternative treatment for several neurological diseases such as neurodegenerative disorders, as well as neurosis, insomnia, and behavioral and psychological symptoms in Alzheimer's disease. Moreover, it has been shown that yokukansan has antidepressant-like and pain-relieving effects in animal models. Recently, several studies have shown that yokukansan has a neuroprotective effect. In this study, we focused on whether or no yokukansan influences cell proliferation related to cell-cycle progression by using B65 neuroblastoma cells derived from monoaminergic neurons...
January 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/27899689/herbal-medicine-for-management-of-the-behavioural-and-psychological-symptoms-of-dementia-bpsd-a-systematic-review-and-meta-analysis
#15
Anna J Hyde, Brian H May, Lin Dong, Mei Feng, Shaonan Liu, Xinfeng Guo, Anthony Lin Zhang, Chuanjian Lu, Charlie Changli Xue
Management of the behavioural and psychological symptoms of dementia remains a challenge worldwide. Herbal medicines may play a role in the development of new interventions. To determine effects of herbal medicines for management of the behavioural and psychological symptoms of dementia, meta-analysis was conducted of 31 controlled trials (3613 participants). Frequently tested herbal medicines were the Ginkgo biloba leaf extract EGb 761 (seven studies) and the multi-ingredient formula Yokukansan (eight studies)...
February 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/27890870/improving-the-quality-of-postgraduate-education-in-traditional-japanese-kampo-medicine-for-junior-residents-an-exploratory-survey-conducted-in-five-institutions-in-the-tohoku-area
#16
Shin Takayama, Seiichi Kobayashi, Soichiro Kaneko, Masao Tabata, Shinya Sato, Keiichi Ishikawa, Saya Suzuki, Ryutaro Arita, Natsumi Saito, Tetsuharu Kamiya, Hitoshi Nishikawa, Yuka Ikeno, Junichi Tanaka, Minoru Ohsawa, Akiko Kikuchi, Takehiro Numata, Hitoshi Kuroda, Michiaki Abe, Satoru Ishibashi, Nobuo Yaegashi, Tadashi Ishii
Traditional Japanese (Kampo) medicine has been widely applied in general medicine in Japan. In 2001, the model core curriculum for Japanese medical education was revised to include Kampo medicine. Since 2007, all 80 Japanese medical schools have incorporated it within their programs. However, postgraduate training or instruction of Kampo medicine has not been recognized as a goal for the clinical training of junior residents by Japan's Ministry of Health, Labour and Welfare; little is known about postgraduate Kampo medicine education...
November 2016: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27700077/semisynthesis-and-structure-activity-studies-of-uncarinic-acid-c-isolated-from-uncaria-rhynchophylla-as-a-specific-inhibitor-of-the-nucleation-phase-in-amyloid-%C3%AE-42-aggregation
#17
Takuya Yoshioka, Kazuma Murakami, Kyohei Ido, Mizuho Hanaki, Kanoko Yamaguchi, Satohiro Midorikawa, Shinji Taniwaki, Hiroki Gunji, Kazuhiro Irie
Oligomers of the 42-mer amyloid-β protein (Aβ42), rather than fibrils, cause synaptic dysfunction in the pathology of Alzheimer's disease (AD). The nucleation phase in a nucleation-dependent aggregation model of Aβ42 is related to the formation of oligomers. Uncaria rhynchophylla is one component of "Yokukansan", a Kampo medicine, which is widely used for treating AD symptoms. Previously, an extract of U. rhynchophylla was found to reduce the aggregation of Aβ42, but its active principles have yet to be identified...
October 28, 2016: Journal of Natural Products
https://www.readbyqxmd.com/read/27582327/the-effect-of-yokukansan-a-traditional-herbal-preparation-used-for-the-behavioral-and-psychological-symptoms-of-dementia-on-the-drug-metabolizing-enzyme-activities-in-healthy-male-volunteers
#18
Hiromi Soraoka, Kentaro Oniki, Kazuki Matsuda, Tatsumasa Ono, Kosuke Taharazako, Yoshihiro Uchiyashiki, Ryoko Kamihashi, Ayana Kita, Ayaka Takashima, Kazuko Nakagawa, Norio Yasui-Furukori, Daisuke Kadowaki, Keishi Miyata, Junji Saruwatari
The concomitant use of herb and prescription medications is increasing globally. Herb-drug interactions are therefore a clinically important problem. Yokukansan (YKS), a Japanese traditional herbal medicine, is one of the most frequently used herbal medicines. It is effective for treating the behavioral and psychological symptoms of dementia. We investigated the potential effects of YKS on drug-metabolizing enzyme activities in humans. An open-label repeat-dose study was conducted in 26 healthy Japanese male volunteers (age: 22...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27497482/yokukansan-in-the-treatment-of-behavioral-and-psychological-symptoms-of-dementia-an-updated-meta-analysis-of-randomized-controlled-trials
#19
Shinji Matsunaga, Taro Kishi, Nakao Iwata
BACKGROUND: Previous clinical studies found that yokukansan has a therapeutic effect on behavioral and psychological symptoms of dementia (BPSD) in dementia patients. OBJECTIVE: To perform an updated meta-analysis of randomized controlled trials (RCTs) testing yokukansan for patients with BPSD. METHODS: Primary efficacy and safety endpoints were BPSD total scores and all-cause discontinuation, respectively. Secondary outcomes were BPSD subscales, cognitive function scores [Mini-mental state examination (MMSE)], activities of daily living (ADL) scores, discontinuation due to adverse events (AEs), and incidences of AEs...
September 6, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27373856/neuropharmacological-efficacy-of-the-traditional-japanese-kampo-medicine-yokukansan-and-its-active-ingredients
#20
REVIEW
Yasushi Ikarashi, Kazushige Mizoguchi
Dementia is a progressive neurodegenerative disorder with cognitive dysfunction, and is often complicated by behavioral and psychological symptoms of dementia (BPSD) including excitement, aggression, and hallucinations. Typical and atypical antipsychotics are used for the treatment of BPSD, but induce adverse events. The traditional Japanese Kampo medicine yokukansan (YKS), which had been originated from the traditional Chinese medicine Yi-Gan-San, has been reported to improve BPSD without severe adverse effects...
October 2016: Pharmacology & Therapeutics
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