Maki Komiyama, Yuka Ozaki, Hiromichi Wada, Hajime Yamakage, Noriko Satoh-Asahara, Akihiro Yasoda, Yoichi Sunagawa, Tatsuya Morimoto, Shinji Tamaki, Masahiro Suzuki, Takuo Shibayama, Toru Kato, Yasumasa Okada, Toshiyuki Kita, Yuko Takahashi, Koji Hasegawa
BACKGROUND: Smoking and depression are closely related and form a vicious cycle. Yokukansan (YiganSan) is a polyherbal remedy that has the effect of calming neuropsychiatric symptoms such as anger and irritation. To examine the efficacy of Yokukansan during smoking cessation (SC) therapy in smokers with depressive tendencies but without major depressive disorders requiring pharmacotherapy. METHODS: A multicenter, double-blind, randomized, placebo-controlled, parallel-group comparison trial was conducted between June 2016 and May 2020 at 12 centers of the National Hospital Organization, Japan...
November 25, 2022: BMC complementary medicine and therapies