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https://www.readbyqxmd.com/read/29929193/induction-of-pro-inflammatory-response-via-activated-macrophage-mediated-nf-%C3%AE%C2%BAb-and-stat3-pathways-in-gastric-cancer-cells
#1
Yujuan Zhou, Longzheng Xia, Qiang Liu, Heran Wang, Jingguan Lin, Linda Oyang, Xiaoyan Chen, Xia Luo, Shiming Tan, Yutong Tian, Min Su, Ying Wang, Pan Chen, Yang Wu, Hui Wang, Qianjin Liao
BACKGROUND/AIMS: Chronic inflammation plays an important role in the initiation and progression of gastric cancer (GC). However, the role and relationship of activated macrophages with gastric mucous epithelium cells in initiating and maintaining the inflammatory process during gastric carcinogenesis remains unclear. METHODS: The tumour associated macrophages (TAMs) density of gastric cancer was characterized by immunohistochemistry, and the relationship between macrophages and gastric epithelium cells was analysed using an in vitro culture system that imitates the inflammatory microenvironment...
June 19, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29929056/n-acetyl-cysteine-inhibits-lipopolysaccharide-mediated-induction-of-interleukin-6-synthesis-in-mc3t3-e1-cells-through-the-nf-kb-signaling-pathway
#2
Ling Guo, Hui Zhang, Wangyang Li, Danting Zhan, Min Wang
BACKGROUND: Interleukin-6 (IL-6) is a potent stimulator of osteoclastic activity. Lipopolysaccharide (LPS) has been shown to regulate the expression of potent inflammatory factors, including TNF-α and IL-6. Currently, effective therapeutic treatments for bacteria-caused bone destruction are limited. N-acetyl cysteine (NAC) is an antioxidant small molecule that possibly modulates osteoblastic differentiation. However, whether NAC can affect the LPS-mediated reduction of IL-6 synthesis in MC3T3-E1 cells is still unknown...
June 6, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29928985/design-and-characterization-of-emulsified-spray-dried-alginate-microparticles-as-a-carrier-for-the-dually-acting-drug-roflumilast
#3
Azza A Mahmoud, Nermeen A Elkasabgy, Abdel Fatah A Abdelkhalek
Roflumilast is a selective inhibitor of phosphodiesterase-4 isoenzyme in lung cells. Having psychiatric adverse reactions when administered orally affects negatively the patients' adherence to the drug. This work aimed to prepare emulsified spray dried alginate microparticles for the pulmonary delivery of roflumilast. Sodium alginate was used as microparticle-forming material, isopropyl myristate as an oil, Tween®80 as surfactant and calcium beta-glycerophosphate as cross-linking agent to enhance the mechanical properties of the particles...
June 18, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29928944/protective-effects-of-apigenin-on-lps-induced-endometritis-via-activating-nrf2-signaling-pathway
#4
Pei-Yue Jiang, Xiao-Jun Zhu, Yi-Na Zhang, Fei-Fei Zhou, Xiao-Fu Yang
Endometritis is a puzzling disease that often associates with severe pelvic pain. In this study, we aimed to detect whether apigenin had protective effect against LPS-induced endometritis, if so, the underlying mechanism was further investigated. Apigenin was administrated 1 h before LPS treatment. The levels of inflammatory cytokines were measured by ELISA. The expression of NF-κB and Nrf2 were detected by Western blot analysis. The results showed that LPS treatment induced severe histological alteration of uterus and this change was attenuated by the treatment of apigenin...
June 18, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29928898/transient-high-pressure-in-pancreatic-ducts-promotes-inflammation-and-alters-tight-junctions-via-calcineurin-signaling-in-mice
#5
Li Wen, Tanveer A Javed, Dean Yimlamai, Amitava Mukherjee, Xiangwei Xiao, Sohail Z Husain
BACKGROUND AND AIMS: Pancreatitis following endoscopic retrograde cholangiopancreatography (PEP) is thought to be provoked by pancreatic ductal hypertension, via unknown mechanisms. We investigated the effects of hydrostatic pressures on the development of pancreatitis in mice. METHODS: We performed studies with Swiss Webster mice, B6129 mice (controls), and B6129 mice with disruption of the protein phosphatase 3, catalytic subunit, beta isoform gene (Cnab-/- mice)...
June 18, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29928491/tnfaip8-promotes-prostate-cancer-cell-survival-by-inducing-autophagy
#6
Suryakant Niture, Malathi Ramalinga, Habib Kedir, Dorrelyn Patacsil, Samiksha S Niture, James Li, Haresh Mani, Simeng Suy, Sean Collins, Deepak Kumar
Tumor necrosis factor-α-inducible protein 8 (TNFAIP8) is a TNF-α inducible anti-apoptotic protein with multiple roles in tumor growth and survival. Mechanisms of cell survival by TNFAIP8 remain elusive. We investigated the role of TNFAIP8 in the regulation of the cell cycle, autophagy, cell survival and neuroendocrine differentiation in prostate cancer cells. We showed that TNFAIP8 dysregulates cell-cycle-related proteins, in PC3 cells. Oncogenic cell survival, drug resistance and dysregulation of cell cycle-related proteins are often associated with autophagy...
June 1, 2018: Oncotarget
https://www.readbyqxmd.com/read/29928409/accumulation-of-t-helper-22-cells-interleukin-22-and-myeloid-derived-suppressor-cells-promotes-gastric-cancer-progression-in-elderly-patients
#7
Xuehua Chen, Yanfu Wang, Jiali Wang, Jinhui Wen, Xuzhao Jia, Xiaojun Wang, Hua Zhang
Chronic inflammation and immunosuppression lead to aging and tumorigenesis. T-helper 22 (Th22) cells, interleukin 22 (IL-22) and myeloid-derived suppressor cells (MDSCs) serve an important role in inflammatory-immune diseases and cancer. However, the status of Th22 cells, IL-22 and MDSCs in aging and elderly gastric cancer progression is unknown. In the present study, 39 elderly patients with gastric cancer (EGC), 32 elderly healthy controls (HE) and 31 young healthy controls (HY) were enrolled, and the peripheral Th22, Th17 and Th1 cells, and MDSCs, were examined using flow cytometry...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928398/hydrogen-rich-solution-attenuates-myocardial-injury-caused-by-cardiopulmonary-bypass-in-rats-via-the-janus-activated-kinase-2-signal-transducer-and-activator-of-transcription-3-signaling-pathway
#8
Keyan Chen, Yingjie Sun, Yugang Diao, Tiezheng Zhang, Wanwei Dong
The incidence of complications and mortality following open-heart surgery with cardiopulmonary bypass (CPB) is associated with the severity of the myocardial injury that occurs during surgery. Hydrogen-rich solution (HRS) may prevent antioxidant stress and inhibit apoptosis and inflammation. The present study was designed to investigate the effects of HRS on CPB-induced myocardial injury, and to investigate its potential regulation of the Janus-activated kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) pathway...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928204/bullous-pemphigoid-associated-with-adalimumab-therapy-in-a-patient-with-ulcerative-colitis
#9
Sebastian Hoffmann, Mark Berneburg, Stephan Schreml
Bullous pemphigoid (BP) is a blistering autoimmune disease mainly observed in elderly patients. Several triggers are known for this autoimmune disease and some drugs are known to be a cause of BP. However, there are only few case reports on the induction of BP under adalimumab therapy. Other autoimmune diseases, such as lupus erythematosus, are also known to occur under TNF inhibition. Here, we report on an 81-year-old patient who received adalimumab for ulcerative colitis and subsequently developed BP. Other causes of BP (tumors, other drugs, viral or toxoplasma infections) were excluded...
May 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29927820/acetyl-11-keto-%C3%AE-boswellic-acid-promotes-osteoblast-differentiation-by-inhibiting-tumor-necrosis-factor-%C3%AE-and-nuclear-factor-%C3%AE%C2%BAb-activity
#10
Fan Bai, Xuewu Chen, Hui Yang, Hong-Guang Xu
Tumor necrosis factor (TNF) -α plays a crucial role in rheumatoid arthritis (RA)-related bone loss disease. The main mechanism of action of RA induced bone loss is the significant inhibitory effect of TNF-α on osteoblast differentiation. TNF-α inhibits osteoblast differentiation mainly by activating nuclear factor (NF) -κB signaling pathway. Owing to the crucial role of TNF-α and NF-κB in the inhibition of osteoblast differentiation, they are considered as targets for the development of therapeutic drugs...
June 20, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29927631/therapeutic-effects-of-the-addition-of-platelet-rich-plasma-to-bioimplants-and-early-rehabilitation-exercise-on-articular-cartilage-repair
#11
Nai-Jen Chang, Yanjmaa Erdenekhuyag, Pei-Hsi Chou, Chih-Jou Chu, Chih-Chan Lin, Ming-You Shie
BACKGROUND: Treating articular cartilage lesions is clinically challenging. However, whether the addition of autologous platelet-rich plasma (PRP) to bioimplants along with early rehabilitation exercise provides therapeutic effects and regenerates the osteochondral defect remains uninvestigated. HYPOTHESIS: The addition of PRP to a polylactic-co-glycolic acid (PLGA) scaffold along with continuous passive motion (CPM) in osteochondral defects may offer beneficial in situ microenvironment changes to facilitate hyaline cartilage and subchondral bone tissue repair...
June 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29927449/real-time-observation-of-leukocyte-endothelium-interactions-in-tissue-engineered-blood-vessel
#12
Z Chen, M Tang, D Huang, W Jiang, M Li, H Ji, J Park, B Xu, L J Atchison, G A Truskey, K W Leong
Human cell-based 3D tissue constructs play an increasing role in disease modeling and drug screening. Inflammation, atherosclerosis, and many autoimmune disorders involve the interactions between immune cells and blood vessels. However, it has been difficult to image and model these interactions under realistic conditions. In this study, we fabricated a perfusion and imaging chamber to allow the real-time visualization of leukocyte perfusion, adhesion, and migration inside a tissue-engineered blood vessel (TEBV)...
June 21, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29927104/affinity-maturation-drives-epitope-spreading-and-generation-of-pro-inflammatory-anti-citrullinated-protein-antibodies-in-rheumatoid-arthritis
#13
Serra E Elliott, Sarah Kongpachith, Nithya Lingampalli, Julia Z Adamska, Bryan J Cannon, Rong Mao, Lisa K Blum, William H Robinson
OBJECTIVE: Rheumatoid arthritis (RA) is characterized by anti-citrullinated protein antibodies (ACPAs), nevertheless, the origin, specificity, and functional properties of ACPAs remain poorly understood. To characterize the evolution of ACPAs, we sequenced the plasmablast antibody repertoire at serial timepoints in subjects with established RA. METHODS: Blood samples were obtained at up to four timepoints from eight anti-CCP+ individuals with established RA. We single-cell sorted CD19+CD3-IgD-CD14-CD20-CD27+CD38++ plasmablasts and co-stained with citrullinated-peptide tetramers to identify ACPA-expressing plasmablasts...
June 21, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29927045/effects-of-curcumin-and-melatonin-on-bone-formation-in-orthopedically-expanded-suture-in-rats-a-biochemical-histological-and-immunohistochemical-study
#14
M G Cesur, K Gülle, F B Şirin, M Akpolat, G Öğrenim, A Alkan, G Cesur
OBJECTS: To investigate the effects of curcumin (CUR) and melatonin (MEL) on new bone formation following rapid maxillary expansion (RME) in rats. SETTING AND SAMPLE POPULATION: For this study, 24 12-week-old adult male Wistar albino rats from the Animal Laboratory at Adnan Menderes University, Faculty of Medicine, were used. MATERIALS AND METHODS: The rats were randomly divided into the following 3 groups (n = 8 each): only expansion (OE), expansion plus MEL (MEL) and expansion plus CUR (CUR)...
June 21, 2018: Orthodontics & Craniofacial Research
https://www.readbyqxmd.com/read/29926673/-effect-of-fracture-of-lower-limbs-with-hemorrhage-on-myocardial-injury-and-its-mechanism-in-rats
#15
Zhao-Hui Li, Ying Zhang, Yan Lu, Qing-Ming Lu, Xiao-Hua Xie
OBJECTIVES: To test whether myocardial apoptosis can be induced by traumatic fracture of lower limbs with hemorrhage, in order to lay a foundation of myocardial injury after traumatic fracture for the follow-up study. METHODS: Twenty SD rats were randomly divided into two groups, i. e. control group and trauma group( n =10). A rat model of traumatic hemorrhage was establish, and a traumatic model of the original generation of myocardial cell culture was constructed in vitro ...
February 8, 2018: Chinese Journal of Applied Physiology
https://www.readbyqxmd.com/read/29926670/-effect-of-autophagy-inhibitor-chloroquine-on-acute-alcoholinduced-liver-disease
#16
Wen-Hua Sang, Mei-Chun Zeng, Sha Chen, Ran Chen, Xiao-Fang Fan, Yong-Sheng Gong, Hai-Lin Zhang, Hong-Yu Zhang, Xiao-Xia Kong
OBJECTIVES: To investigate the role of autophagy inhibitor chloroquine (CQ) in acute ethanol-induced liver injury and its mechenism. METHODS: Twenty-one C57BL/6 male mice were randomly divided into three groups:control group, ethanol group, CQ + ethanol group ( n =7). Mice in ethanol group were administered 33% (v/v) ethanol at a dose of 4.5 g/kg body weight. Ethanol-induced liver steatosis in each group was detected by hematoxylin and eosin staining. Hepatic lipid accumulation was detected by staining with Oil red O...
February 8, 2018: Chinese Journal of Applied Physiology
https://www.readbyqxmd.com/read/29926660/-comparative-study-on-anti-inflammatory-and-immunomodulation-of-different-isatidis-radix-strains-growing-in-gansu-province
#17
Ze-Jun Zhao, Zhi-Wang Wang, Mei Guo, Tao Du, Xia Shi, Jing Shao, Xi-Yan Wen
OBJECTIVE: To investigate anti-inflammatory and immunomodulation effects of different ecotype from Isatidis Radix growing in Gansu province. METHODS: Mice were randomly divided into 6 groups ( n =11)and used the auricular swelling and paw edema to observe the anti-inflammatory effects of Isatidis Radix; Mice were randomly divided into 7 groups ( n =11) and through the gasbag synovitis model to observe the anti-inflammatory effects of Isatidis Radix; Mice were randomly divided into 6 groups ( n =11), the immunosuppressed model were established by injection of cyclophosphamide (CTX) to study the effects of Isatidis Radix on index of thymus, blood routine and cytokines...
January 8, 2018: Chinese Journal of Applied Physiology
https://www.readbyqxmd.com/read/29926649/-effects-of-simulated-100-m-trimix-conventional-diving-on-oxidative-stress-and-inflammatory-reaction-in-rabbits
#18
Yang-Yang Li, Lu Shi, Yan-Meng Zhang, Chan-Juan Xiao, Hong-Tao Liu
OBJECTIVE: To investigate the effects of simulated 100 m Trimix conventional diving on tissue inflammatory cytokines in rabbits. METHODS: Eight New Zealand rabbits were performed a simulated 100 m Trimix conventional diving program which was established according to the Haldane theory. The expression levels of interferon-gamma(IFN- γ ), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-8 (IL-8), myeloperoxidase(MPO) and matrix metallo proteinase-9 (MMP-9) in rabbits lung and brain tissues were detected by Elisa after diving decompression...
January 8, 2018: Chinese Journal of Applied Physiology
https://www.readbyqxmd.com/read/29926390/selenium-deficiency-affects-immune-function-by-influencing-selenoprotein-and-cytokine-expression-in-chicken-spleen
#19
Pervez Ahmed Khoso, Yiming Zhang, Hang Yin, Xiaohua Teng, Shu Li
Se is an important bioelement essential for a healthy immune system. Dietary Se influences both innate and adaptive immune responses. However, the effects of Se deficiency in chicken spleen are still unknown; thus, we designed an experiment to study the role of Se in chicken spleen. A total of 180 one-day-old sea blue white laying hens were randomly allocated into two groups (a control group and a Se-deficient group). The control group was fed a diet supplemented with sodium selenite with a final Se content of 0...
June 20, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29926368/the-effect-of-periodontal-disease-treatment-in-patients-with-continuous-ambulatory-peritoneal-dialysis
#20
Zekeriya Tasdemir, Funda Özsarı Tasdemir, Cem Gürgan, Eray Eroglu, Inayet Gunturk, Ismail Kocyigit
PURPOSE: Chronic inflammation is an obvious risk factor of atherosclerotic diseases, and the presence of periodontal disease is one of the important sources of chronic inflammation in patients with chronic kidney disease (CKD) and diabetes mellitus (DM). Thus, we aimed to investigate the effects of non-surgical periodontal therapy of the patients undergoing CAPD due to diabetic nephropathy, diabetic patients without CKD, and healthy controls on inflammation exponents. METHODS: Thirty-two CAPD patients due to diabetic nephropathy (group III), 31 diabetic patients without nephropathy (group II), and 38 healthy subjects (group I) were enrolled to the study...
June 20, 2018: International Urology and Nephrology
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