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Female reproductive system cancers

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https://www.readbyqxmd.com/read/29750160/temporal-trends-of-common-female-malignances-on-breast-cervical-and-ovarian-cancer-mortality-in-japan-republic-of-korea-and-singapore-application-of-the-age-period-cohort-model
#1
Jinyao Wang, Haizhen Lv, Zhilin Xue, Lu Wang, Zhiqiang Bai
Background: Reproductive system cancer is an important cause of morbidity and mortality worldwide which threatens women's health and lives. Breast, cervical, and ovarian cancer have the higher incidence and mortality among a series of gynecology malignant tumor. We aimed to compare and assess the temporal trends of common female malignances on breast, cervical, and ovarian cancer mortality in developed regions of Asia including Japan, Republic of Korea, and Singapore and analyze the detached effects of chronological age, time period, and birth cohort by age-period-cohort (APC) analysis...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29716743/foxo3a-reverses-the-cisplatin-resistance-in-ovarian-cancer
#2
Mudan Lu, Xuan Chen, Jianping Xiao, Jingying Xiang, Lan Yang, Daozhen Chen
OBJECTIVE: Ovarian cancer is one of the most serious disease in female reproductive system. Platinum is the first-line drug for the treatment of ovarian cancer, while the resistance of platinum drug in clinical hindered the relief ovarian cancer. Our previous study found that decreased FOXO3a might be a poor prognosis in human ovarian cancer. In this research, we study whether FOXO3a was involved in the mechanism of platinum drug resistance. METHODS: The CCK-8 and FACS analysis were used to monitor the survival of ovarian cancer, and the FOXO3a expression was detected by western-blot...
April 28, 2018: Archives of Medical Research
https://www.readbyqxmd.com/read/29697394/specificities-of-endometrial-proliferation-stem-cell-index-distribution-in-endometrioid-carcinoma-of-different-grade-of-malignancy
#3
N Kikalishvili, R Beriashvili, T Muzashvili, G Burkadze
Endometrial neoplasia is the most common malignant tumor of female genital system in developed countries. The incidence of endometrial cancer has increased in the last years and despite advances in diagnosis and treatment, the death rates have steadily been increasing over the past 20 years. Therefore aspects of endometrial cancer development, pathogenesis and effective treatment is especially urgent to this day, as much of the risk for endometrial cancer development is influenced by the environment and lifestyle...
March 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29693131/spermidine%C3%A2-induced-growth-inhibition-and-apoptosis-via-autophagic-activation-in-cervical-cancer
#4
Yu Chen, Haifeng Zhuang, Xuerui Chen, Zheqi Shi, Xu Wang
Cervical cancer is the most common malignancy of the female reproductive tract, and the poor response to prophylactic vaccines and the toxicity of high‑dose chemotherapeutic drugs have limited their clinical application. Spermidine, a natural polyamine detected in all eukaryotic organisms, exhibits functions that promote longevity in multiple model systems and may constitute a promising agent for cancer treatment. However, the potential effectiveness of spermidine in cervical cancer has not yet been fully elucidated, and the underlying molecular mechanisms remain unclear...
April 18, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29692735/mequindox-induced-genotoxicity-and-carcinogenicity-in-mice
#5
Qianying Liu, Zhixin Lei, Qin Wu, Deyu Huang, Shuyu Xie, Xu Wang, Yuanhu Pan, Zonghui Yuan
Mequindox (MEQ), acting as an inhibitor of deoxyribonucleic acid (DNA) synthesis, is a synthetic heterocyclic N -oxides. To investigate the potential carcinogenicity of MEQ, four groups of Kun-Ming (KM) mice (50 mice/sex/group) were fed with diets containing MEQ (0, 25, 55, and 110 mg/kg) for one and a half years. The result showed adverse effects on body weights, feed consumption, hematology, serum chemistry, organ weights, relative organ weights, and incidence of tumors during most of the study period. Treatment-related changes in hematology, serum chemistry, relative weights and histopathological examinations revealed that the hematological system, liver, kidneys, and adrenal glands, as well as the developmental and reproductive system, were the main targets after MEQ administration...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29674220/childbearing-across-borders-fertility-and-parenthood-attitudes-and-decisions-among-breast-cancer-survivors-in-usa-and-portugal
#6
Vânia Gonçalves, Janella Hudson, Maria Cristina Canavarro, Julie Morris, M Catherine Lee, Kristine A Donovan, Steven K Sutton, Susan T Vadaparampil, Gwendolyn P Quinn
OBJECTIVE: To compare fertility and childbearing attitudes and decisions of Portuguese and American female reproductive aged breast cancer survivors. METHODS: This was a cross-sectional study of 102 young breast cancer survivors (59 from Portugal and 43 from USA). Demographic, clinical and reproductive information were collected. Fertility and parenthood attitudes and decisions were assessed through a self-report questionnaire devised specifically for the study...
April 16, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29608330/a-novel-target-of-p53-tcf21-can-respond-to-hypoxia-by-mapk-pathway-inactivation-in-uterine-corpus-endometrial-carcinoma
#7
Qin Li, Yong Lei, Wei Du
Uterine corpus endometrial carcinoma (UCEC) is a common malignancy in the female reproductive system, associated with high morbidity and mortality. Despite the high prevalence of UCEC, molecular understanding of uterine endothelium tumorigenesis remains poorly understood. In this study, we reported that transcription factor 21 (TCF21) inhibits cancer cell proliferation and invasion following overexpression, in vitro and in vivo. Moreover, in response to hypoxia, TCF21 is highly expressed in UCEC cells carrying wild-type p53, and is transcriptional target of p53...
April 2, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29600986/molecular-genetic-models-for-prognosis-of-development-of-tumors-of-reproductive-system-in-women-with-family-history-of-cancer
#8
O V Paliychuk, L Z Polishchuk, Z I Rossokha, V F Chekhun
AIM: To develop a prognostic molecular genetic model for assessing the risk of development of benign and malignant tumors of female reproductive organs (FRO) in patients from cancer-affected families. PATIENTS AND METHODS: The work presents the data on a comprehensive clinical examination of 210 women (90 patients with FRO cancer with aggregation of tumor pathology in families, 65 patients with benign pathology of FRO from cancer-affected families, 55 women - control group of healthy women without family history of cancer)...
March 2018: Experimental Oncology
https://www.readbyqxmd.com/read/29581237/female-fertility-preservation-past-present-and-future
#9
Benjamin Fisch, Ronit Abir
Anti-cancer therapy, particularly chemotherapy damages ovarian follicles and promotes ovarian failure. The only pharmacological means for protecting the ovaries from chemotherapy-induced injury is gonadotrophin-releasing hormone agonist, but its efficiency remains controversial; ovarian transposition is used to shield the ovary from radiation when indicated. Until the late 1990s, the only option for fertility preservation and restoration in women with cancer was embryo cryopreservation. The development of other assisted reproductive technologies such as mature oocyte cryopreservation and in vitro maturation of oocytes has contributed to fertility preservation...
March 26, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29533546/telocytes-in-the-female-reproductive-system-an-overview-of-up-to-date-knowledge
#10
REVIEW
Przemysław Janas, Iwona Kucybała, Małgorzata Radoń-Pokracka, Hubert Huras
Telocytes are emerging cell population localized in the stroma of numerous organs, characterized by a distinctive morphology - small cell body with very long, slender prolongations, termed telopodes. Those cells can be found in the whole female reproductive system: in the vagina, uterus, oviducts and ovaries, mammary glands and also in the placenta. In our review, we aim at complete and transparent revision of the current knowledge of telocytes' localization and function, enriched by the analysis of the possible future direction of development of their clinical applications...
March 13, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29504606/ctd-2020k17-1-a-novel-long-non-coding-rna-promotes-migration-invasion-and-proliferation-of-serous-ovarian-cancer-cells-in-vitro
#11
Linfei Zhu, Qixuan Guo, Xinxin Lu, Junhua Zhao, Jinxin Shi, Zhenning Wang, Xin Zhou
BACKGROUND Ovarian cancer is the most lethal malignant tumor of the female reproductive system, and the metastasis is one of the major factors that contribute to the poor outcome of patients with OC. Accumulating evidence indicates that lncRNAs are expressed and play important regulatory roles in ovarian cancer. MATERIAL AND METHODS Aberrant lncRNAs in primary ovarian cancer tissues (POCTs) and paired omental metastasis tissues (OMTs) of patients with HGSOC were studied via lncRNA microarray. Real-time PCR was performed to examine CTD-2020K17...
March 5, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29502284/fertility-preservation-for-female-cancer-patients
#12
REVIEW
Miyuki Harada, Yutaka Osuga
An improvement in the survival rates of cancer patients and recent advancements in assisted reproductive technologies have led to remarkable progress in oncofertility and fertility preservation treatments. Currently, for adults and postpubertal girls, oocyte or embryo cryopreservation is an established method. If their cancer treatment cannot be postponed for 2 weeks, ovarian tissue cryopreservation is offered as an experimental technique. For prepubertal girls, ovarian tissue cryopreservation is the only option...
March 3, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29477446/estrogen-induced-neuroimmunomodulation-as-facilitator-of-and-barrier-to-reproductive-aging-in-brain-and-lymphoid-organs
#13
REVIEW
Srinivasan ThyagaRajan, Lalgi Hima, Uday P Pratap, Hannah P Priyanka, Ramasamy Vasantharekha
Reproductive aging in females is marked by alterations in gonadal hormones, estrogen and progesterone, that facilitate cessation of reproductive cycles and onset of female-specific diseases such as autoimmune and neurodegenerative diseases, hormone-dependent cancers, and osteoporosis. Bidirectional communication between the three homeostatic systems, nervous system, endocrine system, and immune system, is essential for the maintenance of health and any dysfunction in the cross-talk promotes the development of diseases and cancer...
February 27, 2018: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/29445078/mir-144-potentially-suppresses-proliferation-and-migration-of-ovarian-cancer-cells-by-targeting-runx1
#14
Shichao Han, Jinming Zhu, Yilei Zhang
BACKGROUND Ovarian cancer (OC) is one of the most common malignant diseases of the female reproductive system worldwide. Evidence has shown that microRNAs are involved in the development of ovarian cancer. miR-144, one of these microRNAs, has been found have upregulated expression in various human malignancies. The present study aimed to investigate the role miR-144 in ovarian cancer cell lines and to elucidate the mechanism involved. MATERIAL AND METHODS Human ovarian cancer cell lines (SKOV3/OVCAR3) and a normal ovarian cell line (IOSE80) were used to identify the miR-144 expression though qRT-PCR method...
February 15, 2018: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/29438890/flavonoids-from-chinese-bayberry-leaves-induced-apoptosis-and-g1-cell-cycle-arrest-via-erk-pathway-in-ovarian-cancer-cells
#15
Yu Zhang, Shiguo Chen, Chaoyang Wei, Gary O Rankin, Xingqian Ye, Yi Charlie Chen
Ovarian cancer is one of the leading causes of death related to the female reproductive system in western countries. Adverse side effects and resistance to platinum based chemotherapy have become the major obstacles for ovarian cancer treatment. Natural products have gained great attention in cancer treatment in recent years. Chinese bayberry leaves flavonoids (BLF) containing rich content of myricitrin (myricetin 3-O-rhamnoside) and a part of quercetrin (quercetin 3-rhamnoside) inhibited the growth of an ovarian cancer cell line A2780/CP70...
March 10, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29438648/managing-menopausal-symptoms-after-cancer-an-evidence-based-approach-for-primary-care
#16
Jennifer L Marino, Helen C McNamara, Martha Hickey
Impaired ovarian function and menopausal symptoms are common after cancer treatment. Menopausal symptoms often occur at an earlier age in women with cancer, and may be more severe than in natural menopause; they may be the most persistent and troubling sequelae of cancer. A third of female patients with cancer report dissatisfaction with the quality and length of physician-patient discussions about reproductive health, including menopause. Systemic menopausal hormone therapy is the most effective treatment for menopausal symptoms, but it is not suitable for all patients after cancer - where it is unsuitable, alternative effective non-hormonal treatments are available...
February 19, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/29408871/association-of-cancer-related-mortality-age-and-gonadectomy-in-golden-retriever-dogs-at-a-veterinary-academic-center-1989-2016
#17
Michael S Kent, Jenna H Burton, Gillian Dank, Danika L Bannasch, Robert B Rebhun
Golden retriever dogs have been reported to have an increased prevalence of cancer compared to other breeds. There is also controversy over the effect spay or neuter status might have on longevity and the risk for developing cancer. The electronic medical records system at an academic center was searched for all dogs who had a necropsy exam from 1989-2016. 9,677 canine necropsy examinations were completed of which 655 were golden retrievers. Age was known for 652 with a median age of death 9.15 years. 424 of the 652 (65...
2018: PloS One
https://www.readbyqxmd.com/read/29344168/mir-124-inhibits-invasion-and-induces-apoptosis-of-ovarian-cancer-cells-by-targeting-programmed-cell-death-6
#18
Li Yuan, Shaolin Li, Qi Zhou, Dong Wang, Dongling Zou, Jin Shu, Yu Huang
Epithelial ovarian cancer remains the most common type of malignant tumor of the female reproductive system worldwide. Routine surgery and chemotherapy are the best treatments available for patients with ovarian cancer; however, almost 40% of ovarian cancer cases are intractable, with poor 5-year survival rates. MicroRNAs (miRNA) are endogenous small non-coding RNA molecules that function in transcriptional and post-transcriptional regulation of gene expression in various cellular processes. Recent studies demonstrated that microRNA (miR)-124 was downregulated in numerous types of tumors; however, the function and mechanism underlying miR-124 in epithelial ovarian cancer remain unclear...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29342962/functional-analyses-of-runx3-and-camkiin%C3%AE-in-ovarian-cancer-cell-lines-reveal-tumor-suppressive-functions-for-camkiin%C3%AE-and-dichotomous-roles-for-runx3-transcript-variants
#19
Karolin Heinze, Daniel Kritsch, Alexander S Mosig, Matthias Dürst, Norman Häfner, Ingo B Runnebaum
(1) Background: Epithelial ovarian cancer (EOC) is the most lethal cancer of the female reproductive system. In an earlier study, we identified multiple genes as hypermethylated in tumors of patients with poor prognosis. The most promising combination of markers to predict a patient's outcome was CaMKIINα and RUNX3. Aim of this study was to functionally validate the importance of both genes. (2) Methods: IC50 measurements, cell cycle distribution-, proliferation, and migration experiments were conducted after transgene overexpression in two EOC cell lines...
January 15, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29284773/phenotypic-features-of-endometrial-tumors-in-patients-with-family-history-of-cancer
#20
L G Buchynska, N P Iurchenko, N M Glushchenko, I P Nesina
AIM: To determine the peculiarities of expression of a number of proteins-regulators of the cell cycle in endometrial cancer (EC) cells in patients with a family history of oncological pathologies. PATIENTS AND METHODS: 95 EC patients (stage І-ІІ) were included into the study. Clinical-genealogical analysis was performed. 54 patients (group I) had healthy relatives, and in families of 41 patients (group II) an aggregation of malignant tumors of different genesis (mainly tumors of the gastrointestinal tract and the female reproductive system) was recorded...
December 2017: Experimental Oncology
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