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Botulinic toxin

Kazimierz Tomczykiewicz
Cervical dystonia is the most common form of dystonia in adult age. It is characterized by involuntary muscle contractions that cause abnormal movements and positioning of the head and neck. Symptoms of it are often associated with pain. This distinguishes this form from other dystonia. The drug of choice is botulinum toxin. It effectively reduces both pain and abnormal excessive muscle activity. In some cases, particularly where there is not obtained the full recovery after treatment botulinum toxin we used drugs for systemic effect...
August 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Kazimierz Cervical Dystonia Treatment With Botulin Toxin
Cervical dystonia is the most common form of dystonia in adult age. It is characterized by involuntary muscle contractions that cause abnormal movements and positioning of the head and neck. Symptoms of it are often associated with pain. This distinguishes this form from other dystonia. The drug of choice is botulinum toxin. It effectively reduces both pain and abnormal excessive muscle activity. In some cases, particularly where there is not obtained the full recovery after treatment botulinum toxin we used drugs for systemic effect...
July 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Vimal Veeriah, Angelo Zanniti, Riccardo Paone, Suvro Chatterjee, Nadia Rucci, Anna Teti, Mattia Capulli
Endothelial cells are spatially close to osteoblasts and regulate osteogenesis. Moreover, they are sensitive to mechanical stimuli, therefore we hypothesized that they are implicated in the regulation of bone metabolism during unloading. Conditioned media from endothelial cells (EC-CM) subjected to simulated microgravity (0.08g and 0.008g) increased osteoblast proliferation and decreased their differentiation compared to unit gravity (1g) EC-CM. Microgravity-EC-CM increased the expression of osteoblast Rankl and subsequent osteoclastogenesis, and induced the osteoblast de-differentiating factor, Lipocalin 2 (Lcn2), whose downregulation recovered osteoblast activity, decreased Rankl expression and reduced osteoclastogenesis...
2016: Scientific Reports
Dimos D Mitsikostas
PURPOSE OF REVIEW: This article addresses nocebo in headache. Nocebo is the antipode of placebo and refers to adverse events a person manifests after receiving placebo. RECENT FINDINGS: In randomized trials for migraine prevention meta-analyses revealed that eight out of 20 patients treated with placebo experienced any adverse event. More importantly, one out of 20 patients treated with placebo withdrew treatment because of adverse events. The adverse events in placebo groups mirrored the adverse events expected of the active medication studied, confirming that pretrial suggestions induce the adverse events in placebo-treated patients...
June 2016: Current Opinion in Neurology
Dario Esposito, Francesco Maione, Alessandra D'Alessandro, Giovanni Sarnelli, Giovanni D De Palma
Achalasia is a motility disorder of the esophagus characterized by dysphagia, regurgitation of undigested food, chest pain, weight loss and respiratory symptoms. The most common form of achalasia is the idiopathic one. Diagnosis largely relies upon endoscopy, barium swallow study, and high resolution esophageal manometry (HRM). Barium swallow and manometry after treatment are also good predictors of success of treatment as it is the residue symptomatology. Short term improvement in the symptomatology of achalasia can be achieved with medical therapy with calcium channel blockers or endoscopic botulin toxin injection...
January 25, 2016: World Journal of Gastrointestinal Endoscopy
Yu N Ponomarenko, S V Vasenko, A M Nenko
The study analyses results of treatment of 196 patients, with cerebral palsy, which underwent a course of health-resort treatment is performed. Past medical history of patients for the last 10 years was also analysed. It was found that the use of botulin toxin <A> (BT-A) <Dysport®> as a part of complex rehabilitation of the patients significantly improved the effectiveness of the treatment. It was determined that the reasons of the lack of spasticity reduce are caused by degeneration of the muscles...
August 2015: Voenno-medit︠s︡inskiĭ Zhurnal
P Graziano, G Dell'Aversana Orabona, F Astarita, L M Ponzo, R Nunziata, G Salzano, F Maglitto, D Solari, A Santella, M Cappabianca, G Iaconetta, L Califano
OBJECTIVE: The association of bilateral hypertrophy of temporalis and masseteric muscles is a rare clinical entity. The origin of the condition is unclear, causing cosmetic problems, pain, and functional impairment. PATIENTS AND METHODS: In this paper we analyzed 15 patients treated at the Department of Maxillo-Facial Surgery of the University of Naples Federico II, from 2000 to 2013, for temporalis and/or masseteric muscle hypertrophy, and in particular, a rare case of a patient with a marked bilateral swelling of the temporalis and masseteric region, in conjunction with a review of the literature...
2016: European Review for Medical and Pharmacological Sciences
Rogelio Revuelta-Gutiérrez, Héctor Sebastián Velasco-Torres, Lourdes Olivia Vales Hidalgo, Jaime Jesús Martínez-Anda
BACKGROUND: The coexistence of hemifacial spasm and trigeminal neuralgia, a clinical entity known as painful tic convulsive, was first described in 1910. It is an uncommon condition that is worthy of interest in neurosurgical practice, because of its common pathophysiology mechanism: Neuro-vascular compression in most of the cases. OBJECTIVE: To present 2 cases of painful tic convulsive that received treatment at our institution, and to give a brief review of the existing literature related to this...
January 13, 2016: Cirugia y Cirujanos
Maria Renata Proverbio, Marta Lamba, Alessandro Rossi, Paolo Siani
INTRODUCTION: Foodborne botulism is a neuroparalytic disease caused by ingestion of food contaminated with botulinum toxins. Despite rare the mortality rate is high if untreated. Diagnosis of botulism is still a challenge for clinician, due to the variability of clinical manifestations and disease course. We report on a child with type B botulin intoxication who was early diagnosed and treated underlining that clinical suspicion is crucial to start prompt treatment. CASE PRESENTATION: An 11-year-old boy presented with bilateral ptosis and mydriasis, dry mouth, difficulty in swallowing, dysphonia, urine retention and constipation...
June 2016: Anaerobe
Jonathan M Sykes, Patrick Trevidic, Gustavo A Suárez, Gisella Criollo-Lamilla
The muscular anatomy of the face is complex. Animation patterns of facial muscles vary significantly among individuals. Activity of facial muscles determines expression and emotion and affects the eyes aperture and the amount and extent of facial rhytids. Injection of botulin toxin for facial rejuvenation has become a very popular procedure and allows the practitioner the ability to modulate facial expression and to decrease the amount of facial rhytids. A thorough knowledge of the variant facial anatomy is necessary to maximize the efficiency of botulin toxin injection...
November 2015: Plastic and Reconstructive Surgery
K Isa, K Oka, N Beauchamp, M Sato, K Wada, K Ohtani, S Nakanishi, E McCartney, M Tanaka, T Shimizu, S Kamiya, C Kruger, M Takahashi
Probiotics are live microorganisms ingested for the purpose of conferring a health benefit on the host. Development of new probiotics includes the need for safety evaluations that should consider factors such as pathogenicity, infectivity, virulence factors, toxicity, and metabolic activity. Clostridium butyricum MIYAIRI 588(®) (CBM 588(®)), an anaerobic spore-forming bacterium, has been developed as a probiotic for use by humans and food animals. Safety studies of this probiotic strain have been conducted and include assessment of antimicrobial sensitivity, documentation of the lack of Clostridium toxin genes, and evaluation of CBM 588(®) on reproductive and developmental toxicity in a rodent model...
August 2016: Human & Experimental Toxicology
Virtaj Singh, Andrea Trescot, Isuta Nishio
Although interventional procedures should be used cautiously in the setting of chronic pain, there is a role for a variety of injections to facilitate a patient's overall rehabilitation program. There are many resources available, including a prior issue of Physical Medicine and Rehabilitation Clinics of North America, which discuss the more conventional spinal injections. The focus of this article is on lesser-known injection options for treating chronic pain. The authors separately discuss trigger point injections, regenerative injections (prolotherapy), and injections using botulin toxins...
May 2015: Physical Medicine and Rehabilitation Clinics of North America
Riccardo Marvulli, Pierpaolo Chiumarulo, Mattia Nisi, Laura Barulli, Gianfranco Megna, Fiore Pietro, Giancarlo Ianieri, Marisa Megna
Spasticity is a motor disorder with an increased muscle tone, typically associated with spasms, weakness and lack of coordination. It is an invalidating and debilitating pathology, characterized by pain, limited autonomy in activities of daily living, development of severe lesions. Spasticity can be adequately treated with physiotherapy, muscle relaxants drugs or topical treatment with botulinic toxin type A. Intrathecal baclofen therapy is very effective in the treatment of severe and generalized spasticity...
2015: Endocrine, Metabolic & Immune Disorders Drug Targets
Alexander Slade, Sinisa Stanic
OBJECTIVE: A significant fraction of patients with amyotrophic lateral sclerosis (ALS) are unable to swallow saliva, which may result in the spillage of saliva outside of the oral cavity. Although anticholinergic agents and botulin toxin injections are considered the first line of treatment, they have not been effective for all patients. We performed a literature search on therapeutic salivary gland irradiation in patients with ALS. METHODS: We searched the PubMed for English language publications up to December 2014 on therapeutic salivary gland irradiation in patients with ALS...
May 15, 2015: Journal of the Neurological Sciences
Ilona Kwiecień-Czerwieniec, Jolanta Krukowska, Marta Woldańska-Okońska
INTRODUCTION: Juvenile Cerebral Palsy--is caused by damage of the motor control centers of the developing brain (cerebral refers to the cerebrum, which is the affected area of the brain, although the disorder probably involves connections between the cortex and other parts of the brain and palsy refers to disorder of movement). The clinical symptoms of juvenile cerebral palsy are very diversified and include gross and fine motor-coordination disorders, manual ability, locomotion, perception and response, speech, psychomotor retardation, emotional disorders...
2014: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
H P Kozynets', V D Pinchuk, O S Tkach
Comparative estimation of results for endoscopic lifting of the face upper part in dynamics of early and late postoperative period was adduced. In accordance to results of analysis, concerning the eyebrows height in a control terms, there was established, that through one year postoperatively the eyebrows have a tendency towards ptosis due to activity of the eyes circular muscles. Deterioration of the result achieved post-operatively is less prominent in patients after preliminary chemical denervation of mimic muscles...
May 2014: Klinichna Khirurhiia
S D'Epiro, L Macaluso, M Salvi, C Luci, C Mattozzi, F Marzocca, V Salvo, M Scarnò, S Calvieri, A G Richetta
BACKGROUND: Hyperhidrosis is a condition characterized by generalized or localized hyperfunction of the eccrine sweat glands with a deep negative impact on patient's quality of life. OBJECTIVES: To evaluate the efficacy and the safety of Botulin Toxin A (BTX-A) intradermal injection in the treatment of primary axillary and palmar hyperhidrosis, investigating symptoms-free period, and the subjective improving of quality life. MATERIALS AND METHODS: 50 consecutive patients with primary hyperhidrosis were evaluated detecting age, gender, hyperhidrosis onset period, disease duration and years of treatment with BTX-A, Minor's iodine test, Hyperhidrosis Disease Severity Scale (HDSS), Dermatology Life Quality Index (DLQI)...
2014: La Clinica Terapeutica
Pier Alberto Testoni
Acute recurrent pancreatitis (ARP) refers to a clinical entity characterized by episodes of acute pancreatitis which occurs on more than one occasion. Recurrence of pancreatitis generally occurs in a setting of normal morpho-functional gland, however, an established chronic disease may be found either on the occasion of the first episode of pancreatitis or during the follow-up. The aetiology of ARP can be identified in the majority of patients. Most common causes include common bile duct stones or sludge and bile crystals; sphincter of oddi dysfunction; anatomical ductal variants interfering with pancreatic juice outflow; obstruction of the main pancreatic duct or pancreatico-biliary junction; genetic mutations; alcohol consumption...
December 7, 2014: World Journal of Gastroenterology: WJG
C Tassorelli, R De Icco, E Alfonsi, M Bartolo, M Serrao, M Avenali, I De Paoli, C Conte, N G Pozzi, P Bramanti, G Nappi, G Sandrini
INTRODUCTION: Pisa syndrome (PS) is a tonic lateral flexion of trunk that represents a disabling complication of advanced Parkinson disease (PD). Conventional rehabilitation treatment (CT) ameliorates axial posture and trunk mobility in PD patients, but the improvement tends to wane in 4-6 months. Botulin toxin (BT) may reduce muscle hyperactivity, therefore improving CT effectiveness. We evaluated whether the injection of incabotulinum toxin type A (iBTA) into the hyperactive trunk muscles might improve the effectiveness of rehabilitation in a group of PD patients with PS...
November 2014: Parkinsonism & related Disorders
Nadia Rucci, Mattia Capulli, Sara Gemini Piperni, Alfredo Cappariello, Patrick Lau, Petra Frings-Meuthen, Martina Heer, Anna Teti
Mechanical loading represents a crucial factor in the regulation of skeletal homeostasis. Its reduction causes loss of bone mass, eventually leading to osteoporosis. In a previous global transcriptome analysis performed in mouse calvarial osteoblasts subjected to simulated microgravity, the most upregulated gene compared to unit gravity condition was Lcn2, encoding the adipokine Lipocalin 2 (LCN2), whose function in bone metabolism is poorly known. To investigate the mechanoresponding properties of LCN2, we evaluated LCN2 levels in sera of healthy volunteers subjected to bed rest, and found a significant time-dependent increase of this adipokine compared to time 0...
February 2015: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
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