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https://www.readbyqxmd.com/read/29140932/characteristics-of-treatment-experienced-hiv-infected-african-children-and-adolescents-initiating-darunavir-and-or-etravirine-based-antiretroviral-treatment
#1
Bethany Corrigan, Irene Mukui, Lloyd Mulenga, Nobuhle Mthethwa, Mosilinyane Letsie, Stephanie Bruno, Natella Rakhmanina
BACKGROUND: Data are limited on the selection and sequencing of second and third-line pediatric antiretroviral treatment (ART) in resource-limited settings. This study aimed to evaluate characteristics of African pediatric patients initiated on darunavir (DRV) and/or etravirine (ETR) through a specific drug donation program. METHODS: This was a cross-sectional study of baseline immunologic, virologic and demographic characteristics of children and adolescents initiating DRV- and/or ETR-based ART...
November 14, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29133023/in-search-of-the-right-time-and-right-place-screening-adolescents-and-youth-for-human-immunodeficiency-virus-in-the-united-states
#2
EDITORIAL
Natella Rakhmanina, George K Siberry
No abstract text is available yet for this article.
November 10, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29132280/mixed-results-the-protective-role-of-schooling-in-the-hiv-epidemic-in-swaziland
#3
Alan Whiteside, Andriana Vinnitchok, Tengetile Dlamini, Khanya Mabuza
Swaziland has the highest HIV prevalence in the world. It is recognised that young women, especially adolescents, are particularly vulnerable to HIV infection and bear a disproportionate burden of HIV incidence. The HIV data from Swaziland show the location of the epidemic, which is particularly high among adolescent girls and young women. This paper is based on research in Swaziland, commissioned because of the perception that large numbers of children were dropping out of the school. It was assumed that these "dropouts" had increased risk of HIV exposure...
December 2017: African Journal of AIDS Research: AJAR
https://www.readbyqxmd.com/read/29122384/strengthening-global-vaccine-access-for-adolescents-and-adults
#4
REVIEW
Angeline Nanni, Stefanie Meredith, Stephanie Gati, Karin Holm, Tom Harmon, Ann Ginsberg
Global immunization efforts to date have heavily focused on infants and children, with noted success on public health. Healthy adolescents and adults contribute to the economic growth and development of countries but efforts to ensure vaccine coverage for these groups receive inadequate global attention and resources. Emerging epidemics for a number of infectious diseases including Ebola, Zika, dengue, malaria and the continuing epidemics of tuberculosis and several sexually transmitted infections, including HIV, HPV and Hepatitis B, have high incidence and prevalence in adolescents and adults...
November 6, 2017: Vaccine
https://www.readbyqxmd.com/read/29117799/subclinical-executive-function-impairment-in-children-with-asymptomatic-treated-phenylketonuria-a-comparison-with-children-with-immunodeficiency-virus
#5
Patrizia Bisiacchi, Vincenza Tarantino, Giovanni Mento
In this study we compared the neuropsychological profile of phenylketonuria (PKU) and human immunodeficiency virus (HIV) to examine the specificity of the executive function (EF) impairment reported in these two patologies. A total of 55 age-matched children and adolescents were assessed, including 11 patients with PKU, 16 patients with HIV and 28 healthy controls, underwent a neuropsychological assessment. Although neither the PKU nor the HIV group scored below the normative ranges, both groups showed lower scores in neuropsychological tests engaging EFs than controls...
November 9, 2017: Cognitive Neuropsychology
https://www.readbyqxmd.com/read/29112991/immuno-virological-response-and-associated-factors-amongst-hiv-1-vertically-infected-adolescents-in-yaound%C3%A3-cameroon
#6
Joseph Fokam, Serge Clotaire Billong, Franck Jogue, Suzie Moyo Tetang Ndiang, Annie Carole Nga Motaze, Koki Ndombo Paul, Anne Esther Njom Nlend
INTRODUCTION: Limited studies have reported the outcomes of lifelong antiretroviral therapy (ART) amongst adolescents living with HIV (ALWHIV) in resource-limited settings (RLS), thus classifying this population as underserved. We therefore aimed to ascertain the immunological and virological responses, and associated factors amongst Cameroonian ALWHIV. METHOD: A cross-sectional and observational study was conducted from January through May 2016 at the National Social Insurance Fund Health Centre in Yaoundé-Cameroon...
2017: PloS One
https://www.readbyqxmd.com/read/29111893/-psychological-health-of-children-with-chronic-physical-illness-and-their-parents-results-from-meta-analyses
#7
Martin Pinquart
Psychological Health of Children with Chronic Physical Illness and their Parents - Results from Meta-Analyses The present paper summarizes results from meta-analyses on psychological well-being of children with chronic physical illnesses and their parents. At the beginning, we discuss potential reasons for psychological effects of a chronic physical illness on children and adolescents as well as their parents. We then summarize results of meta-analyses of studies that compared aspects of mental health of children with a chronic physical illness and their parents with families of healthy children...
November 2017: Praxis der Kinderpsychologie und Kinderpsychiatrie
https://www.readbyqxmd.com/read/29111178/dose-dependent-neurocognitive-deficits-following-postnatal-day-10-hiv-1-viral-protein-exposure-relationship-to-hippocampal-anatomy-parameters
#8
Sylvia Fitting, Kristen A McLaurin, Rosemarie M Booze, Charles F Mactutus
Despite the availability of antiretroviral prophylactic treatment, pediatric human immunodeficiency virus type 1 (HIV-1) continues to be a significant risk factor in the post-cART era. The time of infection (i.e., during pregnancy, delivery or breastfeeding) may play a role in the development of neurocognitive deficits in pediatric HIV-1. HIV-1 viral protein exposure on postnatal day (P)1, preceding the postnatal brain growth spurt in rats, had deleterious effects on neurocognitive development and anatomical parameters of the hippocampus (Fitting et al...
October 27, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29108797/lopinavir-plus-nucleoside-reverse-transcriptase-inhibitors-lopinavir-plus-raltegravir-or-lopinavir-monotherapy-for-second-line-treatment-of-hiv-earnest-144-week-follow-up-results-from-a-randomised-controlled-trial
#9
James G Hakim, Jennifer Thompson, Cissy Kityo, Anne Hoppe, Andrew Kambugu, Joep J van Oosterhout, Abbas Lugemwa, Abraham Siika, Raymond Mwebaze, Aggrey Mweemba, George Abongomera, Margaret J Thomason, Philippa Easterbrook, Peter Mugyenyi, A Sarah Walker, Nicholas I Paton
BACKGROUND: Millions of HIV-infected people worldwide receive antiretroviral therapy (ART) in programmes using WHO-recommended standardised regimens. Recent WHO guidelines recommend a boosted protease inhibitor plus raltegravir as an alternative second-line combination. We assessed whether this treatment option offers any advantage over the standard protease inhibitor plus two nucleoside reverse-transcriptase inhibitors (NRTIs) second-line combination after 144 weeks of follow-up in typical programme settings...
November 3, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29107569/school-support-as-structural-hiv-prevention-for-adolescent-orphans-in-western-kenya
#10
Hyunsan Cho, Isabella Mbai, Winnie Kavulani Luseno, Marcia Hobbs, Carolyn Halpern, Denise Dion Hallfors
PURPOSE: Using a clustered randomized controlled trial design, we evaluated whether support to keep Kenyan orphaned adolescents in school reduces the risk of HIV infection. METHODS: Participants included 835 orphaned boys and girls in grades 7 and 8 (mean age at the baseline = 15 years) in western Kenya. Primary schools (N = 26) were randomized to the study condition. Intervention participants received school uniforms, payment of tuition when they transitioned into high school, and nurse visits to monitor school absenteeism and provide assistance to stay in school...
October 26, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29104904/the-effect-of-community-based-support-for-caregivers-on-the-risk-of-virological-failure-in-children-and-adolescents-with-hiv-in-harare-zimbabwe-zenith-an-open-label-randomised-controlled-trial
#11
Rashida A Ferrand, Victoria Simms, Ethel Dauya, Tsitsi Bandason, Grace Mchugh, Hilda Mujuru, Prosper Chonzi, Joanna Busza, Katharina Kranzer, Shungu Munyati, Helen A Weiss, Richard J Hayes
Background: Children and adolescents have poorer HIV treatment outcomes than adults. We aimed to assess the effect of community-based support for caregivers of HIV-infected children and adolescents, who are key mediators to children engaging with care, on treatment outcomes. Methods: In this open-label, randomised contolled trial, we recruited children aged 6-15 years with newly-diagnosed HIV attending primary health-care clinics in Harare, Zimbabwe. Children were randomly assigned to receive decentralised primary health-care clinic-based HIV care (control group), according to national guidelines for 18 months, or decentralised care plus structured support visits by trained community health workers (intervention group) according to national guidelines for 18 months...
November 2017: Lancet Child Adolesc Health
https://www.readbyqxmd.com/read/29104848/cultural-adaptation-of-an-evidence-informed-psychosocial-intervention-to-address-the-needs-of-phiv-youth-in-thailand
#12
Gisselle Pardo, Chutima Saisaengjan, Priya Gopalan, Jintanat Ananworanich, Sudrak Lakhonpon, Danielle Friedman Nestadt, Torsak Bunupuradah, Claude Ann Mellins, Mary McKernan McKay
Globally, pediatric HIV has largely become an adolescent epidemic. Thailand has the highest HIV prevalence in Asia (1.2%), with more than 14,000 children living with HIV. There is growing demand for evidence-based psychosocial interventions for this population that include health and mental health support and sexual risk reduction, which can be integrated into HIV care systems. To address this need, a multidisciplinary team of Thai and US researchers adapted an existing evidence-informed, family-based intervention, The Collaborative HIV Prevention and Adolescent Mental Health Program + (CHAMP+), which has been tested in multiple global trials...
2017: Global Social Welfare: Research, Policy & Practice
https://www.readbyqxmd.com/read/29103190/factors-related-to-incomplete-adherence-to-antiretroviral-therapy-among-adolescents-attending-three-hiv-clinics-in-the-copperbelt-zambia
#13
Julie A Denison, Catherine Packer, Randy M Stalter, Harry Banda, Sarah Mercer, Namakau Nyambe, Patrick Katayamoyo, Jonathan K Mwansa, Donna R McCarraher
Little is known about adherence to antiretroviral therapy (ART) among adolescents in sub-Saharan Africa, where the majority of the world's HIV-positive adolescents reside. We assessed individual, household, and HIV self-management characteristics associated with a 48-hour treatment gap in the preceding 3 months, and a pharmacy medication possession ratio (MPR) that assessed the number of ART pills dispensed divided by the number of ART pills required in the past 6 months, among 285 Zambians, ages 15-19 years...
November 4, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29100708/safety-and-immune-response-after-two-dose-meningococcal-c-conjugate-immunization-in-hiv-infected-children-and-adolescents-in-rio-de-janeiro-brazil
#14
Ana Cristina C Frota, Bianca Ferreira, Lee H Harrison, Gisele S Pereira, Wania Pereira-Manfro, Elizabeth S Machado, Ricardo Hugo de Oliveira, Thalita F Abreu, Lucimar G Milagres, Cristina B Hofer
We aimed to evaluate immunogenicity and adverse events (AEs) after a booster dose of Meningococcal C conjugated (MCC) vaccine in HIV-infected children and adolescents, who had a previous low seroconversion rate after priming with MCC, at a reference HIV-care center in Rio de Janeiro. METHODS: 2-18 years old HIV-infected subjects with CD4+ T-lymphocyte cell (CD4) ≥15%, without active infection or antibiotic use, were enrolled to receive 2 doses of conjugated meningococcal C oligosaccharide-CRM197 12-18 months apart...
October 31, 2017: Vaccine
https://www.readbyqxmd.com/read/29094229/regular-marijuana-use-is-associated-with-poor-viral-suppression-in-hiv-infected-adolescents-and-young-adults
#15
Amelia B Thompson, Scott E Gillespie, Jasper Hood, LaTeshia Thomas-Seaton, Sophia A Hussen, Andres F Camacho-Gonzalez
There is a paucity of data regarding the impact of drug use on HIV suppression and care retention among adolescents and young adults (AYAs). We recruited a clinic-based sample of HIV infected AYAs to assess the prevalence of self-reported drug use. Clinical data, including retention and viral suppression, were abstracted from the electronic medical record. Logistic regression was used to evaluate marijuana and illicit drug use associations and to identify other risk factors. Of 200 participants (mean age 21, 2...
November 1, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29090395/gender-sexual-self-efficacy-and-consistent-condom-use-among-adolescents-living-in-the-hiv-hyper-endemic-setting-of-soweto-south-africa
#16
Kalysha Closson, Janan Janine Dietrich, Nathan J Lachowsky, Busi Nkala, Alexis Palmer, Zishan Cui, Jason Chia, Robert S Hogg, Glenda Gray, Cari L Miller, Angela Kaida
Within HIV-endemic settings, few studies have examined gendered associations between sexual self-efficacy (SSE), one's confidence or perceived control over sexual behavior, and uptake of HIV prevention behaviors. Using cross-sectional survey data from 417 sexually-experienced adolescents (aged 14-19, median age = 18, 60% female) in Soweto, South Africa, we measured SSE using a 6-item scale (range:0-6) with 'high-SSE' = score > 3 (study alpha = 0.75). Gender-stratified logistic regression models assessed associations between high-SSE and lifetime consistent condom use...
October 31, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29077720/goal-directed-therapy-for-suspected-acute-bacterial-meningitis-in-adults-and-adolescents-in-sub-saharan-africa
#17
Emma C Wall, Mavuto Mukaka, Brigitte Denis, Veronica S Mlozowa, Malango Msukwa, Khumbo Kasambala, Mulinda Nyrienda, Theresa J Allain, Brian Faragher, Robert S Heyderman, David G Lalloo
BACKGROUND: Mortality from acute bacterial meningitis (ABM) in sub-Saharan African adults and adolescents exceeds 50%. We tested if Goal Directed Therapy (GDT) was feasible for adults and adolescents with clinically suspected ABM in Malawi. MATERIALS AND METHODS: Sequential patient cohorts of adults and adolescents with clinically suspected ABM were recruited in the emergency department of a teaching hospital in Malawi using a before/after design. Routine care was monitored in year one (P1)...
2017: PloS One
https://www.readbyqxmd.com/read/29076059/impact-of-care-at-foster-homes-on-the-health-related-quality-of-life-of-hiv-infected-children-and-adolescents-a-cross-sectional-study-from-india
#18
K G Gopakumar, Kamalakshi G Bhat, Shantharam Baliga, Nitin Joseph, Neha Mohan, Avinash K Shetty
PURPOSE: To assess the impact of care at foster homes on the health-related quality of life (HRQOL) of children living with HIV (CLHIV), attending a referral ART Centre, and to compare their HRQOL with children living in their own homes. METHODS: A cross-sectional study was conducted in 144 CLHIV between 5 and 18 years of age, attending a referral ART Centre in South India to assess their HRQOL using the standard PedsQL™ 4.0 questionnaire. Data were then analysed to compare the HRQOL of children living in foster homes to those children living in their own homes...
October 26, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/29069298/high-hiv-incidence-and-prevalence-and-associated-factors-among-adolescent-sexual-minority-males-3-cities-2015
#19
Alexandra B Balaji, Qian An, Justin C Smith, Michael E Newcomb, Brian Mustanski, Nikhil G Prachand, Kathleen A Brady, Sarah Braunstein, Gabriela Paz-Bailey
Background: Much has been written about the impact of HIV among young (13-24) sexual minority men (SMM). Evidence for concern is substantial for emerging adult (18-24) SMM. Data documenting the burden and associated risk factors of HIV among adolescent SMM (<18) remains limited. Methods: Adolescent SMM aged 13-18 years were recruited in three cities (Chicago; New York City; Philadelphia) for interview and HIV testing. We used chi-square tests for percentages of binary variables and one-way ANOVA for means of continuous variables to assess differences by race-ethnicity in behaviors...
October 24, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29067834/mindfulness-instruction-for-hiv-infected-youth-a-randomized-controlled-trial
#20
Lindsey Webb, Carisa Perry-Parrish, Jonathan Ellen, Erica Sibinga
HIV-infected youth experience many stressors, including stress related to their illness, which can negatively impact their mental and physical health. Therefore, there is a significant need to identify potentially effective interventions to improve stress management, coping, and self-regulation. The object of the study was to assess the effect of a mindfulness-based stress reduction (MBSR) program compared to an active control group on psychological symptoms and HIV disease management in youth utilizing a randomized controlled trial...
October 25, 2017: AIDS Care
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