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https://www.readbyqxmd.com/read/28723709/delivering-prep-to-pregnant-and-breastfeeding-women-in-sub-saharan-africa-the-implementation-science-frontier
#1
Dvora L Joseph Davey, Linda-Gail Bekker, Pamina Gorbach, Thomas Coates, Landon Myer
: HIV acquisition during pregnancy and postpartum periods remains high despite increased access to and initiation of antiretroviral therapy in sub-Saharan Africa. Moreover, maternal seroconversion during pregnancy and breastfeeding remains a source of significant paediatric HIV infection in the region. In order to curb vertical HIV transmission, HIV acquisition during pregnancy and lactation must significantly decline. Biological and behavioural factors contribute to high HIV incidence, including hormonal changes that alter genital mucosal surfaces, and frequent condomless sex with HIV-infected partners or partners of unknown serostatus...
July 18, 2017: AIDS
https://www.readbyqxmd.com/read/28715157/use-of-the-shangring-circumcision-device-in-boys-below-18-years-old-in-kenya-results-from-a-pilot-study
#2
Quentin D Awori, Richard K Lee, Phillip S Li, Jared N Moguche, Dan Ouma, Betsy Sambai, Marc Goldstein, Mark A Barone
INTRODUCTION: Male circumcision is a proven prevention strategy against the spread of HIV. The World Health Organization's new 2016-2021 strategic framework on voluntary medical male circumcision (VMMC) targets 90% of males aged 10-29 years to receive circumcision by 2021 in 14 priority sub-Saharan countries while anticipating an increase in the demand for infant circumcision. It also states that the use of circumcision devices is a safe and efficient innovation to accelerate attainment of these goals...
July 12, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28711527/paediatric-hiv-the-unfinished-business
#3
Martina Penazzato, Frank Lule, Shaffiq Essajee
No abstract text is available yet for this article.
July 12, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28708808/hiv-viral-load-suppression-in-adults-and-children-receiving-antiretroviral-therapy-results-from-the-iedea-collaboration
#4
Awachana Jiamsakul, Azar Kariminia, Keri N Althoff, Carina Cesar, Claudia P Cortes, Mary-Ann Davies, Viet Chau Do, Brian Eley, John Gill, Nagalingeswaran Kumarasamy, Daisy Maria Machado, Richard Moore, Hans Prozesky, Elizabeth Zaniewski, Matthew Law
BACKGROUND: Having 90% of patients on antiretroviral therapy (ART) and achieving an undetectable viral load (VL) is one of the 90:90:90 by 2020 targets. In this global analysis, we investigated the proportions of adult and paediatric patients with VL suppression in the first three years after ART initiation. METHODS: Patients from the IeDEA cohorts who initiated ART between 2010 and 2014 were included. Proportions with VL suppression (<1000 copies/mL) were estimated using: (i) strict intention-to-treat (ITT) - loss to follow-up (LTFU) and dead patients counted as having detectable VL; and (ii) modified ITT - LTFU and dead patients were excluded...
July 8, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28696188/evolution-of-cross-neutralizing-antibodies-and-mapping-epitope-specificity-in-plasma-of-chronic-hiv-1-infected-antiretroviral-therapy-na%C3%A3-ve-children-from-india
#5
Muzamil A Makhdoomi, Lubina Khan, Sanjeev Kumar, Heena Aggarwal, Ravinder Singh, Rakesh Lodha, Mohit Singla, Bimal K Das, Sushil K Kabra, Kalpana Luthra
Delineating the factors leading to the development of broadly neutralizing antibodies (bnAbs) during natural HIV-1 infection and dissecting their epitope specificities generates useful information for vaccine design. This is the first longitudinal study to assess the plasma-neutralizing antibody response and neutralizing determinants in HIV-1-infected children from India. We enrolled 26 and followed up 20 antiretroviral therapy (ART)-naïve, asymptomatic, chronic HIV-1-infected children. Five (19.2 %) baseline and 10 (50 %) follow-up plasma samples neutralized ≥50 % of subtypes A, B and C tier 2 viruses at an ID50 titre ≥150...
July 12, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28695551/cohort-profile-the-kilombero-and-ulanga-antiretroviral-cohort-kiularco-a-prospective-hiv-cohort-in-rural-tanzania
#6
Emilio Letang, Aneth Vedastus Kalinjuma, Tracy R Glass, Anna Gamell, Herry Mapesi, George Rocky Sikalengo, Lameck Bonaventure Luwanda, Dorcas Mnzava, Alex J Ntamatungiro, Regina Ndaki, Gideon Francis, Fiona Vanobberghen, Hansjakob Furrer, Thomas Klimkait, Ingrid Felger, Marcel Tanner, Christoph Hatz, Maja Weisser, Manuel Battegay, Kiularco Study Group
BACKGROUND: The Kilombero and Ulanga Antiretroviral Cohort (KIULARCO) is a single-site, open and ongoing prospective cohort of people living with human immunodeficiency virus (PLWHIV) established in 2005 at the Chronic Diseases Clinic of Ifakara (CDCI), within the Saint Francis Referral Hospital (SFRH) in Ifakara, Tanzania. The objectives of KIULARCO are to (i) provide patient and cohort-level information on the outcomes of HIV treatment; (ii) provide cohort-level information on opportunistic infections and comorbidities; (iii) evaluate aspects of human immunodeficiency virus (HIV) care and treatment that have national or international policy relevance; (iv) provide a platform for studies on improving HIV care and treatment in sub-Saharan Africa; and (v) contribute to generating local capacity to deal with the challenges posed by the HIV/AIDS pandemic in this region...
July 11, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28691440/high-risk-of-loss-to-follow-up-among-south-african-children-on-art-during-transfer-a-retrospective-cohort-analysis-with-community-tracing
#7
Chloe A Teasdale, Nonzwakazi Sogaula, Katharine A Yuengling, Zachary J Peters, Anthony Mutiti, Lungile Pepeta, Elaine J Abrams
INTRODUCTION: Decentralization of HIV care for children has been recommended to improve paediatric outcomes by making antiretroviral treatment (ART) more accessible. We documented outcomes of children transferred after initiating ART at a large tertiary hospital in the Eastern Cape of South Africa. METHODS: Electronic medical records for all children 0-15 years initiating ART at Dora Nginza Hospital (DNH) in Port Elizabeth, South Africa January 2004 to September 2015 were examined...
June 28, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28691433/taking-a-critical-look-at-the-unaids-global-estimates-on-paediatric-and-adolescent-hiv-survival-and-death
#8
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
June 28, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28686654/a-retrospective-case-cohort-study-comparing-treatment-outcomes-in-abacavir-versus-stavudine-containing-first-line-antiretroviral-treatment-regimens-in-children-3yrs-old-at-a-paediatric-programme-based-in-soweto-south-africa
#9
Haseena Cassim, Kennedy Otwombe, Erica Lazarus, Afaaf Liberty, Glenda E Gray, Oppel B W Greeff, Avy Violari
INTRODUCTION: The current World Health Organization guideline for first line antiretroviral therapy (ART) in HIV-infected children recommends the use of abacavir and lamivudine as nucleoside backbones and no longer includes stavudine. We compared treatment outcomes with abacavir (ABC) versus stavudine (d4T) in a cohort of HIV-1 infected children 6 and 12 months after antiretroviral therapy was initiated. METHODS: This was a retrospective case-cohort study, using programmatic data from children enrolled in the Paediatric Wellness Programme at the Perinatal HIV Research Unit in Soweto, South Africa between 2005 and 2013...
2017: PloS One
https://www.readbyqxmd.com/read/28681826/prevalence-of-transfusion-transmitted-viral-pathogens-among-health-care-workers-and-risk-mitigation-programme-in-a-paediatric-tertiary-care-hospital
#10
Charu Nayyar, Rushika Saksena, Vikas Manchanda
The health-care workers (HCWs) are at an occupational risk of exposure to blood-borne pathogens, mainly, HIV, hepatitis B virus (HBV) and hepatitis C virus. HBV is currently the only blood-borne virus for which a vaccine is available. All health-care institutions must encourage the HCWs to undergo screening for blood-borne pathogens.
April 2017: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28664684/cross-cultural-assessment-of-hiv-associated-cognitive-impairment-using-the-kaufman-assessment-battery-for-children-a-systematic-review
#11
Kaylee S van Wyhe, Tanya van de Water, Michael J Boivin, Mark F Cotton, Kevin Gf Thomas
INTRODUCTION: Despite improved efficacy of, and access to, combination antiretroviral therapy (cART), HIV-associated cognitive impairments remain prevalent in both children and adults. Neuropsychological tests that detect such impairment can help clinicians formulate effective treatment plans. The Kaufman Assessment Battery for Children (KABC), although developed and standardized in the United States, is used frequently in many different countries and cultural contexts to assess paediatric performance across various cognitive domains...
June 14, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28609403/early-antiretroviral-therapy-reduces-hiv-dna-following-perinatal-hiv-infection
#12
Caroline Foster, Matthew Pace, Steve Kaye, Emily Hopkins, Mathew Jones, Nicola Robinson, Sarah Fidler, John Frater
: The impact of antiretroviral therapy (ART) on the size of the HIV reservoir has implications for virological remission in adults, but is not well characterised in perinatally acquired infection (PaHIV). In a prospective observational study of 20 children with PaHIV and sustained viral suppression on ART for >5 years, proviral DNA was significantly higher in deferred (>4 years) versus early (first year of life) ART recipients (p = 0.0062), and correlated with age of initiation (p = 0.13; r = 0...
June 12, 2017: AIDS
https://www.readbyqxmd.com/read/28570368/prioritizing-the-most-needed-formulations-to-accelerate-paediatric-antiretroviral-therapy-scale-up
#13
Martina Penazzato, Claudia Palladino, Nandita Sugandhi
PURPOSE OF REVIEW: Initiatives are in place to reach super-fast targets by 2018 for paediatric patients living with HIV. However, these efforts are unlikely to be successful until better paediatric antiretrovirals and treatment strategies are available. This commentary reviews the specific features, challenges, and recent developments in paediatric HIV treatment to determine optimal regimen sequencing and use of available drug options. It also outlines a medium and long-term vision for treatment optimization as endorsed by the paediatric antiretroviral drug optimization group...
July 2017: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/28555322/assessment-of-airway-compression-on-chest-radiographs-in-children-with-pulmonary-tuberculosis
#14
Lisel Richter-Joubert, Savvas Andronikou, Lesley Workman, Heather J Zar
BACKGROUND: Because small, pliable paediatric airways are easily compressed by enlarged lymph nodes, detection of radiographic airway compression might be an objective criterion for diagnosing pulmonary tuberculosis. OBJECTIVE: To investigate the frequency and inter-observer agreement of airway compression on chest radiographs in children with pulmonary tuberculosis compared to those with a different lower respiratory tract infection. MATERIALS AND METHODS: Chest radiographs of children with suspected pulmonary tuberculosis were read by two readers according to a standardised format and a third reader when there was disagreement...
May 29, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28530047/what-is-it-going-to-take-to-move-youth-related-hiv-programme-policies-into-practice-in-africa
#15
Daniella Mark, Lina Taing, Lucie Cluver, Chris Collins, Kate Iorpenda, Catarina Andrade, Luann Hatane
INTRODUCTION: HIV has been reported to be the leading cause of mortality amongst adolescents in Africa. This has brought attention to the changes in service provision and health management that many adolescents living with HIV experience when transferring from specialized paediatric- or adolescent-focused services to adult care. When transition is enacted poorly, adherence may be affected and the continuum of care disrupted. As the population of HIV-infected adolescents grows, effective and supported transition increases in significance as an operational imperative...
May 16, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28530045/mental-health-challenges-among-adolescents-living-with-hiv
#16
Rachel C Vreeman, Brittany M McCoy, Sonia Lee
INTRODUCTION: Mental health is a critical and neglected global health challenge for adolescents infected with HIV. The prevalence of mental and behavioural health issues among HIV-infected adolescents may not be well understood or addressed as the world scales up HIV prevention and treatment for adolescents. The objective of this narrative review is to assess the current literature related to mental health challenges faced by adolescents living with HIV, including access to mental health services, the role of mental health challenges during transition from paediatric to adult care services and responsibilities, and the impact of mental health interventions...
May 16, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28530044/a-review-of-transition-experiences-in-perinatally-and-behaviourally-acquired-hiv-1-infection-same-same-but-different
#17
Phung Khanh Lam, Sarah Fidler, Caroline Foster
INTRODUCTION: Despite sharing common psychosocial and developmental experiences, adolescents living with perinatally and behaviourally acquired HIV-1 infection are different in terms of timing of HIV infection and developmental stage at infection. Therefore, it is of interest to identify similarities and differences between these two groups of adolescents living with HIV in their experiences, facilitators and barriers during the transition process. METHODS: A detailed literature search of peer-reviewed published papers was conducted on PubMed to identify relevant original research or viewpoints published up to September 2016...
May 16, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28530043/the-happy-teen-programme-a-holistic-outpatient-clinic-based-approach-to-prepare-hiv-infected-youth-for-the-transition-from-paediatric-to-adult-medical-care-services-in-thailand
#18
Rangsima Lolekha, Vitharon Boon-Yasidhi, Yossawadee Na-Nakorn, Boonying Manaboriboon, Warunee Punpanich Vandepitte, Michael Martin, Jariya Tarugsa, Wipada Nuchanard, Pimsiri Leowsrisook, Ketwadee Lapphra, Piyarat Suntarattiwong, Vorapathu Thaineua, Kulkanya Chokephaibulkit
INTRODUCTION: We developed an 18-month Happy Teen 2 (HT2) programme comprised of a one-day workshop, two half-day sessions, and three individual sessions to prepare HIV-infected youth for the transition from paediatric to adult HIV care services. We describe the programme and evaluate the change in youth's knowledge scores. METHODS: We implemented the HT2 programme among HIV-infected Thai youth aged 14-22 years who were aware of their HIV status and receiving care at two hospitals in Bangkok (Siriraj Hospital, Queen Sirikit National Institute of Child Health [QSNICH])...
May 16, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28530042/growing-up-with-perinatal-hiv-changes-in-clinical-outcomes-before-and-after-transfer-to-adult-care-in-the-uk
#19
Ali Judd, Intira Jeannie Collins, Francesca Parrott, Teresa Hill, Sophie Jose, Deborah Ford, Hibo Asad, Diana M Gibb, Caroline Sabin
INTRODUCTION: With improved survival, adolescents with perinatal HIV (PHIV) are transitioning from paediatric to adult care, but there are few published data on clinical outcomes post-transfer. Using linked data from patients in the national UK/Ireland paediatric cohort (CHIPS) and an adult UK cohort of outpatient clinics (UK CHIC), we describe mortality and changes in immunological status post-transfer. METHODS: Participants in CHIPS aged ≥13 years by the end of 2013 were linked to the UK CHIC database...
May 16, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28530041/hiv-healthcare-transition-outcomes-among-youth-in-north-america-and-europe-a-review
#20
Vicki Tepper, Stefanie Zaner, Patrick Ryscavage
INTRODUCTION: The transition from paediatric to adult care poses risks to the health of young adults living with HIV if unsuccessful, including interruptions in care and poor health outcomes. Evolving best practices in HIV healthcare transition should ideally be informed by real-world qualitative and quantitative clinical healthcare transition outcomes. There has been a recent proliferation of HIV healthcare transition outcome research, largely from Europe and North America. METHODS: A literature search was undertaken using the online databases PubMed, Web of Science, and Google Scholar...
May 16, 2017: Journal of the International AIDS Society
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