Pietro Berico, Maguelone Nogaret, Max Cigrang, Antonin Lallement, Fatemeh Vand-Rajabpour, Amanda Flores-Yanke, Giovanni Gambi, Guillaume Davidson, Leane Seno, Julian Obid, Bujamin H Vokshi, Stephanie Le Gras, Gabrielle Mengus, Tao Ye, Carlos Fernandez Cordero, Mélanie Dalmasso, Emmanuel Compe, Corine Bertolotto, Eva Hernando, Irwin Davidson, Frédéric Coin
Super-enhancers (SEs) are stretches of enhancers ensuring a high level of expression of key genes associated with cell function. The identification of cancer-specific SE-driven genes is a powerful means for the development of innovative therapeutic strategies. Here, we identify a MITF/SOX10/TFIIH-dependent SE promoting the expression of BAHCC1 in a broad panel of melanoma cells. BAHCC1 is highly expressed in metastatic melanoma and is required for tumor engraftment, growth, and dissemination. Integrative genomics analyses reveal that BAHCC1 is a transcriptional regulator controlling expression of E2F/KLF-dependent cell-cycle and DNA-repair genes...
November 2, 2023: Cell Reports