keyword
https://read.qxmd.com/read/38504320/association-between-tranexamic-acid-administration-and-mortality-based-on-the-trauma-phenotype-a-retrospective-analysis-of-a-nationwide-trauma-registry-in-japan
#1
JOURNAL ARTICLE
Jotaro Tachino, Shigeto Seno, Hisatake Matsumoto, Tetsuhisa Kitamura, Atsushi Hirayama, Shunichiro Nakao, Yusuke Katayama, Hiroshi Ogura, Jun Oda
BACKGROUND: In trauma systems, criteria for individualised and optimised administration of tranexamic acid (TXA), an antifibrinolytic, are yet to be established. This study used nationwide cohort data from Japan to evaluate the association between TXA and in-hospital mortality among all patients with blunt trauma based on clinical phenotypes (trauma phenotypes). METHODS: A retrospective analysis was conducted using data from the Japan Trauma Data Bank (JTDB) spanning 2019 to 2021...
March 19, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38491142/prognostic-impact-and-predictors-of-persistent-renal-dysfunction-in-acute-kidney-injury-after-percutaneous-coronary-intervention-for-acute-myocardial-infarction
#2
JOURNAL ARTICLE
Takuya Nakamura, Makoto Watanabe, Junichi Sugiura, Atsushi Kyodo, Saki Nobuta, Kazutaka Nogi, Yasuki Nakada, Satomi Ishihara, Yukihiro Hashimoto, Hitoshi Nakagawa, Tomoya Ueda, Ayako Seno, Taku Nishida, Kenji Onoue, Shungo Hikoso
This study aimed to evaluate the prognostic impact and predictors of persistent renal dysfunction in acute kidney injury (AKI) after an emergency percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI). A total of 877 patients who underwent emergency PCI for AMI were examined. AKI was defined as serum creatinine (SCr) ≥ 0.3 mg/dL or ≥ 50% from baseline within 48 h after PCI. Persistent AKI was defined as residual impairment of SCr ≥ 0...
March 15, 2024: Scientific Reports
https://read.qxmd.com/read/38474146/monocytes-as-targets-for-immunomodulation-by-regional-citrate-anticoagulation
#3
JOURNAL ARTICLE
Giovana Seno Di Marco, Achmet Imam Chasan, Göran Ramin Boeckel, Katrin Beul, Hermann Pavenstädt, Johannes Roth, Marcus Brand
Immune alterations in end-stage renal patients receiving hemodialysis are complex and predispose patients to infections. Anticoagulation may also play an immunomodulatory role in addition to the accumulation of uremic toxins and the effects of the dialysis procedure. Accordingly, it has been recently shown that the infection rate increases in patients under regional citrate anticoagulation (RCA) compared with systemic heparin anticoagulation (SHA). We hypothesized that RCA affects the immune status of hemodialysis patients by targeting monocytes...
March 1, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473420/high-her2-intratumoral-heterogeneity-is-a-predictive-factor-for-poor-prognosis-in-early-stage-and-locally-advanced-her2-positive-breast-cancer
#4
JOURNAL ARTICLE
Tomonori Tanei, Shigeto Seno, Yoshiaki Sota, Takaaki Hatano, Yuri Kitahara, Kaori Abe, Nanae Masunaga, Masami Tsukabe, Tetsuhiro Yoshinami, Tomohiro Miyake, Masafumi Shimoda, Hideo Matsuda, Kenzo Shimazu
PURPOSE: Breast cancer tumors frequently have intratumoral heterogeneity (ITH). Tumors with high ITH cause therapeutic resistance and have human epidermal growth factor receptor 2 (HER2) heterogeneity in response to HER2-targeted therapies. This study aimed to investigate whether high HER2 heterogeneity levels were clinically related to a poor prognosis for HER2-targeted adjuvant therapy resistance in primary breast cancers. METHODS: This study included patients with primary breast cancer ( n = 251) treated with adjuvant HER2-targeted therapies...
March 5, 2024: Cancers
https://read.qxmd.com/read/38461966/occurrence-of-aflatoxin-m-1-and-estimate-of-dietary-exposure-in-cheeses-from-organic-and-conventional-production-systems
#5
JOURNAL ARTICLE
Marisa Matias de França, Renata Maria Corrêa Santos de Oliveira, Silvia Helena Seraphin de Godoy, Thais Camilo Corrêa, Maria Fernanda de Castro Burbarelli, Leonardo de Oliveira Seno, Anna Luiza Farias Alencar, Fernanda Bovo, Andrezza Maria Fernandes, Ricardo Luiz de Souza Moro
This study aimed to compare AFM1 occurrence in different cheese types produced by organic and conventional systems; and to evaluate the risk of food exposure to AFM1. A total of 176 commercial cheeses of 17 types were analyzed, 84 of organic and 92 of conventional production. Determination of AFM1 was performed by high performance liquid chromatography (HPLC), being detected in 30.5% of samples, with 4.8% of organic cheese samples presenting quantifiable AFM1 values between 0.88 and 1.50 μg/kg. On the other hand, 4...
March 8, 2024: Journal of Food Protection
https://read.qxmd.com/read/38461170/anti-integrin-%C3%AE-v%C3%AE-6-autoantibodies-are-a-potential-biomarker-for-ulcerative-colitis-like-immune-checkpoint-inhibitor-induced-colitis
#6
JOURNAL ARTICLE
Masataka Yokode, Masahiro Shiokawa, Hisato Kawakami, Takeshi Kuwada, Yoshihiro Nishikawa, Yuya Muramoto, Hiroki Kitamoto, Makoto Okabe, Hajime Yamazaki, Norihiro Okamoto, Toshihiro Morita, Kazuya Ohno, Risa Nakanishi, Ikuhisa Takimoto, Muneji Yasuda, Koki Chikugo, Shimpei Matsumoto, Hiroyuki Yoshida, Sakiko Ota, Takeharu Nakamura, Hirokazu Okada, Tomonori Hirano, Nobuyuki Kakiuchi, Tomoaki Matsumori, Shuji Yamamoto, Norimitsu Uza, Makoto Ooi, Yuzo Kodama, Tsutomu Chiba, Hidetoshi Hayashi, Hiroshi Seno
BACKGROUND: No specific biomarker for immune checkpoint inhibitor (ICI)-induced colitis has been established. Previously, we identified anti-integrin αvβ6 autoantibodies in >90% of patients with ulcerative colitis (UC). Given that a subset of ICI-induced colitis is similar to UC, we aimed to clarify the relationship between such autoantibodies and ICI-induced colitis. METHODS: Serum anti-integrin αvβ6 autoantibody levels were compared between 26 patients with ICI-induced colitis and 157 controls...
March 9, 2024: British Journal of Cancer
https://read.qxmd.com/read/38449971/anorexia-nervosa-with-intermittent-fever-due-to-diet-induced-thermogenesis-a-case-report
#7
Atsuhiro Ijiri, Soichiro Seno, Nobuaki Kiriu, Hiroshi Kato, Tetsuro Kiyozumi
Diet-induced thermogenesis, influenced primarily by protein intake, generates energy from food. Herein, we present the case of anorexia nervosa in a 30-year-old woman, who developed intermittent fever while transitioning from continuous to intermittent tube feeding, with an increase in protein intake. Extensive investigations ruled out infection- or drug-related causes, indicating that intermittent fever resulted from diet-induced thermogenesis due to high protein administration. Recognizing the potential for diet-induced thermogenesis in cases of fever during tube feeding is crucial to avoid unnecessary antibiotic use and prevent the discontinuation of essential medications...
February 2024: Curēus
https://read.qxmd.com/read/38423941/plasmacytoma-of-the-maxillary-sinus-in-a-patient-with-refractory-multiple-myeloma
#8
JOURNAL ARTICLE
Miguel Antonio Lasheras-Pérez, Ignacio Torres-Navarro, Javier López-Davia
No abstract text is available yet for this article.
February 28, 2024: Medicina Clínica
https://read.qxmd.com/read/38411682/-mobile-health-applications-mhealth-apps-for-breastfeeding-a-qualitative-review-using-the-mobile-application-rating-scale
#9
JOURNAL ARTICLE
Giulia Maga, Arianna Magon, Deborah Pedrina, Martina Pappalardo, Elsa Del Bo, Gianluca Conte, Rosario Caruso, Cristina Arrigoni
INTRODUCTION: mHealth apps are the most commonly used applications by women for seeking information and support for breastfeeding. The primary goal of this study is to provide a quality assessment of Italian-language mHealth apps for breastfeeding using the Italian version of the Mobile App Rating Scale (I-MARS). METHODS: A systematic search was conducted on the Apple App Store, Google Play Store, and Windows Store. Inclusion criteria were: mHealth apps available in Italian, free of charge, and focused on the theme of breastfeeding...
March 2024: Recenti Progressi in Medicina
https://read.qxmd.com/read/38403112/-treatment-of-displaced-intra-articular-calcaneal-fractures-using-a-sinus-tarsi-approach-surgical-technique
#10
JOURNAL ARTICLE
Juan Mingo Robinet, Lucía González García, Carmen González Alonso
No abstract text is available yet for this article.
February 23, 2024: Revista Española de Cirugía Ortopédica y Traumatología
https://read.qxmd.com/read/38402514/what-influence-could-the-acceptance-of-visitors-cause-on-the-epidemic-dynamics-of-a-reinfectious-disease-a-mathematical-model
#11
JOURNAL ARTICLE
Ying Xie, Ishfaq Ahmad, ThankGod I S Ikpe, Elza F Sofia, Hiromi Seno
The globalization in business and tourism becomes crucial more and more for the economical sustainability of local communities. In the presence of an epidemic outbreak, there must be such a decision on the policy by the host community as whether to accept visitors or not, the number of acceptable visitors, or the condition for acceptable visitors. Making use of an SIRI type of mathematical model, we consider the influence of visitors on the spread of a reinfectious disease in a community, especially assuming that a certain proportion of accepted visitors are immune...
February 25, 2024: Acta Biotheoretica
https://read.qxmd.com/read/38377179/designer-high-density-lipoprotein-particles-enhance-endothelial-barrier-function-and-suppress-inflammation
#12
JOURNAL ARTICLE
Yueh-Chien Lin, Steven Swendeman, Irina S Moreira, Avishek Ghosh, Andrew Kuo, Nícia Rosário-Ferreira, Shihui Guo, Alan Culbertson, Michel V Levesque, Andreane Cartier, Takahiro Seno, Alec Schmaier, Sylvain Galvani, Asuka Inoue, Samir M Parikh, Garret A FitzGerald, David Zurakowski, Maofu Liao, Robert Flaumenhaft, Zeynep H Gümüş, Timothy Hla
High-density lipoprotein (HDL) nanoparticles promote endothelial cell (EC) function and suppress inflammation, but their utility in treating EC dysfunction has not been fully explored. Here, we describe a fusion protein named ApoA1-ApoM (A1M) consisting of apolipoprotein A1 (ApoA1), the principal structural protein of HDL that forms lipid nanoparticles, and ApoM, a chaperone for the bioactive lipid sphingosine 1-phosphate (S1P). A1M forms HDL-like particles, binds to S1P, and is signaling competent. Molecular dynamics simulations showed that the S1P-bound ApoM moiety in A1M efficiently activated EC surface receptors...
February 20, 2024: Science Signaling
https://read.qxmd.com/read/38362598/integrated-analyses-of-the-genetic-and-clinicopathological-features-of-cholangiolocarcinoma-cholangiolocarcinoma-may-be-characterized-by-mismatch-repair-deficiency
#13
JOURNAL ARTICLE
Kenta Makino, Takamichi Ishii, Haruhiko Takeda, Yoichi Saito, Yukio Fujiwara, Masakazu Fujimoto, Takashi Ito, Satoshi Wakama, Ken Kumagai, Fumiaki Munekage, Hiroshi Horie, Katsuhiro Tomofuji, Yu Oshima, Elena Yukie Uebayashi, Takayuki Kawai, Satoshi Ogiso, Ken Fukumitsu, Atsushi Takai, Hiroshi Seno, Etsuro Hatano
Cholangiolocarcinoma (CLC) is a primary liver carcinoma that resembles the canals of Hering and that has been reported to be associated with stem cell features. Due to its rarity, the nature of CLC remains unclear, and its pathological classification remains controversial. To clarify the positioning of CLC in primary liver cancers and identify characteristics that could distinguish CLC from other liver cancers, we performed integrated analyses using whole-exome sequencing (WES), immunohistochemistry, and a retrospective review of clinical information on eight CLC cases and two cases of recurrent CLC...
February 16, 2024: Journal of Pathology
https://read.qxmd.com/read/38336506/maintenance-steroid-therapy-is-associated-with-decreased-risk-of-malignancy-and-better-prognosis-of-patients-with-autoimmune-pancreatitis-a-multicenter-cohort-study-in-japan
#14
JOURNAL ARTICLE
Tetsuya Takikawa, Kazuhiro Kikuta, Takanori Sano, Tsukasa Ikeura, Nao Fujimori, Takeji Umemura, Itaru Naitoh, Hiroshi Nakase, Hiroyuki Isayama, Atsushi Kanno, Ken Kamata, Yuzo Kodama, Dai Inoue, Akio Ido, Toshiharu Ueki, Hiroshi Seno, Hiroaki Yasuda, Eisuke Iwasaki, Takayoshi Nishino, Kensuke Kubota, Toshihiko Arizumi, Atsushi Tanaka, Kazushige Uchida, Ryotaro Matsumoto, Shin Hamada, Seiji Nakamura, Kazuichi Okazaki, Yoshifumi Takeyama, Atsushi Masamune
BACKGROUND/OBJECTIVES: The association between autoimmune pancreatitis (AIP) and pancreatic cancer (PC) remains controversial. This study aimed to clarify the long-term prognosis and risk of malignancies in AIP patients in Japan. METHODS: We conducted a multicenter retrospective cohort study on 1364 patients with type 1 AIP from 20 institutions in Japan. We calculated the standardized incidence ratio (SIR) for malignancies compared to that in the general population...
January 19, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38322115/digging-out-mdig-from-the-mess-of-h3k9me3-otx2-and-myc-signaling-in-human-cancers
#15
EDITORIAL
Ziwei Wang, Chitra Thakur, Akimasa Seno, Fei Chen
No abstract text is available yet for this article.
2024: International Journal of Biological Sciences
https://read.qxmd.com/read/38295932/genomic-and-epigenetic-characterization-of-the-arsenic-induced-oncogenic-microrna-21
#16
JOURNAL ARTICLE
Haoyan Ji, Zhuoyue Bi, Aashna S Pawar, Akimasa Seno, Bandar Saeed Almutairy, Yao Fu, Yiran Qiu, Wenxuan Zhang, Ziwei Wang, Chitra Thakur, Hongjuan Cui, Liqun Yang, Fei Chen
As one of the first identified oncogenic microRNAs, the precise details concerning the transcriptional regulation and function of microRNA-21 (miR-21) are still not completely established. The miR-21 gene is situated on chromosome 17q23.2, positioned at the 3'-UTR of the gene that encodes vacuole membrane protein-1 (VMP1). In this current study, we presented evidence indicating that miR-21 possesses its own gene promoter, which can be found in the intron 10 of the VMP1 gene. Chromatin immunoprecipitation followed by global DNA sequencing (ChIP-seq) revealed the presence of a broad H3K4me3 peak spanning the entire gene body of the primary miR-21 and the existence of super-enhancer clusters in the close proximity to both the miR-21 gene promoter and the transcription termination site in arsenic (As3+ )-induced cancer stem-like cells (CSCs) and human induced pluripotent stem cells (hiPSCs)...
January 29, 2024: Environmental Pollution
https://read.qxmd.com/read/38266367/a-rare-case-report-of-renal-vein-embolization-after-failed-selective-angioembolization-to-treat-delayed-complication-of-percutaneous-nephrolithotomy
#17
Doddy Hami Seno, Moammar Andar Roemare Siregar, Andika Afriansyah, I Putu Kokohana Arisutawan, Kevin Leonardo
INTRODUCTION: Percutaneous nephrolithotomy (PCNL) has been considered the standard procedure for renal caliculi for its safety, shorter operative time, and cost-effectivity. Despite being minimally invasive, rare complications may still occur. This case presented a rare case of renal venous pseudoaneurysm after PCNL. PRESENTATION OF CASE: A 34-year-old male was diagnosed with left lower calyx renal stone sized 14x13x8 mm with 388-571 Hounsfield Unit (HU). He underwent left mini PCNL with standard protocol...
January 12, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38257088/intestinal-morphology-and-glucose-transporter-gene-expression-under-a-chronic-intake-of-high-sucrose
#18
JOURNAL ARTICLE
Kana Yamamoto, Norio Harada, Takuma Yasuda, Tomonobu Hatoko, Naoki Wada, Xuejing Lu, Youhei Seno, Takashi Kurihara, Shunsuke Yamane, Nobuya Inagaki
Sucrose is a disaccharide that is degraded into fructose and glucose in the small intestine. High-sucrose and high-fructose diets have been reported, using two-dimensional imaging, to alter the intestinal morphology and the expression of genes associated with sugar transport, such as sodium glucose co-transporter 1 (SGLT1), glucose transporter 2 (GLUT2), and glucose transporter 5 (GLUT5). However, it remains unclear how high-fructose and high-sucrose diets affect the expression of sugar transporters and the intestinal morphology in the whole intestine...
January 7, 2024: Nutrients
https://read.qxmd.com/read/38254392/plastinate-library-a-tool-to-support-veterinary-anatomy-learning
#19
JOURNAL ARTICLE
Rafael Senos
The shortage of both time for anatomy courses in the new veterinary medicine curriculum and instructors prepared to teach biomedical sciences has raised a crisis in anatomical education. Often, students spend time out of their classes trying to learn not only concepts but also laboratory-wise content from 2D materials such as books and videos. In addition, since the global COVID-19 pandemic lockdown, studying and habits have been reviewed, with many people adopting an at-home style. The purpose of this study was to evaluate students' acceptance of taking plastinate anatomical specimens to study at home...
January 10, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38243965/effects-of-choline-supplementation-in-diets-on-juvenile-pacu-piaractus-mesopotamicus-productive-performance-proximate-composition-and-serum-lipid-level
#20
JOURNAL ARTICLE
Antonio Cesar Godoy, Fábio Bittencourt, Leticia Fantini-Hoag, Claucia Aparecida Honorato, Deividy Miranda da Silva, Altevir Signor, Leonardo de Oliveira Seno, Maria Fernanda de Castro Burbarelli, Wilson Rogério Boscolo, Dacley Hertes Neu
INTRODUCTION: Pacu (Piaractus mesopotamicus) is a Brazilian fish species of high commercial value and has emerged as one of the main species with potential for intensive farming. This study aimed to investigate the impact of choline supplementation on productive performance, visceral fat, hepatosomatic indices, proximate composition, serum biochemical profile, and liver coloration in juvenile pacu (Piaractus mesopotamicus). METHOD: The 60-day experiment was conducted in the experimental hatchery of the Study Group of Aquaculture Management - GEMAq of the State University of West Paraná, Brazil...
January 17, 2024: Recent Adv Food Nutr Agric
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