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https://www.readbyqxmd.com/read/29130299/-role-of-vitamin-d-in-female-reproduction
#1
Vincenzo DE Leo, Valentina Cappelli, Giuseppe Morgante, Alessandra DI Sabatino
La vit. D, o calcitriolo, è stata identificata inizialmente nei primi anni '20 ed ha un ruolo chiave nella regolazione del metabolismo osseo, nell'omeostasi del calcio e del fosforo e nel promuovere la mineralizzazione ossea. Le azioni della vit. D sono mediante tramite un recettore nucleare (VDR), che è espresso in numerosi organi come l'intestino, l'osso e il rene, ma anche nelle gonadi, nel seno, nel pancreas, nel sistema cardiovascolare, nel cervello (microglia) e nelle cellule del sistema immunitario...
November 10, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/29084399/hepatitis-c-treatment-with-sofosbuvir-and-ledipasvir-accompanied-by-immediate-improvement-in-hemoglobin-a1c
#2
Atsuyuki Ikeda, Kaori Ikeda, Atsushi Takai, Ken Takahashi, Yoshihide Ueda, Hiroyuki Marusawa, Horoshi Seno, Nobuya Inagaki, Hiroyuki Kokuryu
BACKGROUND/AIMS: Direct-acting antiviral agents (DAAs) have increased the sustained viral response rate with minimal adverse effects and short treatment duration. In addition, recent data suggest the possibility that hepatitis C virus (HCV) clearance results in rapid improvement in metabolic pathways. The aim of the present study was to evaluate whether the DAA treatment without ribavirin lowers hemoglobin A1c (HbA1c) at 12 weeks after therapy completion. METHODS: We performed an observational study to assess the effect of sofosbuvir and ledipasvir (SOF/LED) treatment on glycemic control...
October 30, 2017: Digestion
https://www.readbyqxmd.com/read/29080485/suppression-of-the-release-of-arsenic-from-arsenopyrite-by-carrier-microencapsulation-using-ti-catechol-complex
#3
Ilhwan Park, Carlito Baltazar Tabelin, Kagehiro Magaribuchi, Kensuke Seno, Mayumi Ito, Naoki Hiroyoshi
Arsenopyrite is the most common arsenic-bearing sulfide mineral in nature, and its weathering contributes to acid mine drainage (AMD) formation and the release of toxic arsenic (As). To mitigate this problem, carrier-microencapsulation (CME) using titanium (Ti)-catechol complex (i.e., Ti-based CME) was investigated to passivate arsenopyrite by forming a protective coating. Ti(4+) ion dissolved in sulfuric acid and catechol were used to successfully synthesize Ti(IV) tris-catecholate complex, [Ti(Cat)3](2-), which was stable in the pH range of 5-12...
October 14, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29067115/advanced-glycation-end-products-and-lipopolysaccharides-stimulate-interleukin-6-secretion-via-the-rage-tlr4-nf-%C3%AE%C2%BAb-ros-pathways-and-resveratrol-attenuates-these-inflammatory-responses-in-mouse-macrophages
#4
Ayaka Ohtsu, Yui Shibutani, Kotomi Seno, Hisataka Iwata, Takehito Kuwayama, Koumei Shirasuna
Macrophages are essential for regulating the physiology of pregnancy; however, excessive inflammatory responses to macrophages, induced by infection and/or endogenous danger signals, may potentially result in complications during pregnancy. Advanced glycation end-products (AGE) and lipopolysaccharides (LPS) are known to induce inflammation and are associated with adverse developmental outcomes. The aim of the present study was to examine the effect of AGE and LPS on cytokines in the J774 murine macrophage cell line and the potential effect of resveratrol on AGE- and LPS-induced inflammation in macrophages...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29055675/a-transient-insulin-system-dysfunction-in-newborn-rat-brain-followed-by-neonatal-intracerebroventricular-administration-of-streptozotocin-could-be-accompanied-by-a-labile-cognitive-impairment
#5
Zohreh Abbasi, Fatemeh Behnam-Rassouli, Mohammad Mahdi Ghahramani Seno, Masoud Fereidoni
The early postnatal period is a critical period of hippocampus development, which is highly dependent on insulin receptor (IR) signaling and very important in cognitive function. The present study was conducted in order to present a model of neonatal transient brain insulin system dysfunction through finding an appropriate dose of injection of streptozotocin (STZ) during the neonatal period. Sixty male Wistar rat pups were divided into 4 groups of 15 and received intracerebroventricular saline or STZ (icv-STZ) (15, 20 and 25μg/kg) on postnatal day 7...
October 18, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/29040364/preliminary-3-year-evaluation-of-experience-with-silksurface-and-velvetsurface-motiva-silicone-breast-implants-a-single-center-experience-with-5813-consecutive-breast-augmentation-cases
#6
Marcos Sforza, Renato Zaccheddu, Angelo Alleruzzo, Adriano Seno, Domenico Mileto, Arnaldo Paganelli, Hassan Sulaiman, Michael Payne, Lajos Maurovich-Horvat
Background: Silicone breast implants have been in use for breast augmentation for more than 50 years, but technological innovation has been lacking in implant design until recently. Objectives: This study was designed to evaluate the complication and reoperation rates following breast augmentation utilizing the Motiva silicone breast implants. Methods: This retrospective study evaluated the safety of Motiva implants in 5813 consecutive cases of breast augmentation...
September 14, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29033437/acute-anorectal-thrombophlebitis-caused-by-a-protein-c-deficiency
#7
Yuji Eso, Satoshi Yoshiji, Yuto Nakakubo, Minoru Matsuura, Hiroshi Seno
A 46-year-old man visited the emergency department of our hospital with a 3-day history of anal pain, hemorrhaging, and a slight fever. He had previously been diagnosed with protein C deficiency and was prescribed dabigatran, a direct oral anticoagulant. Contrast-enhanced computed tomography showed severe rectal wall thickening with partial defect of enhancement. In addition, sigmoidoscopy revealed a dusky purplish swollen anorectal mucosa just above the dentate line. He was diagnosed with acute anorectal thrombophlebitis, and anticoagulant therapy with heparin was initiated...
October 16, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29030203/characterization-and-clinical-evaluation-of-a-novel-2d-detector-array-for-conventional-and-flattening-filter-free-fff-imrt-pre-treatment-verification
#8
Yuvaraj Sekar, Johannes Thoelking, Miriam Eckl, Irakli Kalichava, Dwi Seno Kuncoro Sihono, Frank Lohr, Frederik Wenz, Hansjoerg Wertz
BACKGROUND AND PURPOSE: The novel MatriXX(FFF) (IBA Dosimetry, Germany) detector is a new 2D ionization chamber detector array designed for patient specific IMRT-plan verification including flattening-filter-free (FFF) beams. This study provides a detailed analysis of the characterization and clinical evaluation of the new detector array. MATERIAL AND METHODS: The verification of the MatriXX(FFF) was subdivided into (i) physical dosimetric tests including dose linearity, dose rate dependency and output factor measurements and (ii) patient specific IMRT pre-treatment plan verifications...
October 10, 2017: Zeitschrift Für Medizinische Physik
https://www.readbyqxmd.com/read/29028431/interferon-tau-regulates-cytokine-production-and-cellular-function-in-human-trophoblast-cell-line
#9
Nao Tanikawa, Kotomi Seno, Ryouka Kawahara-Miki, Koji Kimura, Shuichi Matsuyama, Hisataka Iwata, Takehito Kuwayama, Koumei Shirasuna
Type I interferons (IFN), including IFN-beta (IFNB), activate multiple STAT signaling to drive various biological responses. Another type I IFN, IFN-tau (IFNT), secreted by ruminant embryonic trophoblast cells, has multiple functions with low cytotoxicity. Here, we examined the effects of IFNT on human trophoblast cell functions. First, we performed next-generation sequencing and demonstrated that IFNT-dependent changes in the human Sw.71 trophoblast cell line are partly mediated by proinflammatory as well as IFN signaling...
October 2017: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/29021259/preload-stress-echocardiography-predicts-outcomes-in-patients-with-preserved-ejection-fraction-and-low-gradient-aortic-stenosis
#10
Kenya Kusunose, Hirotsugu Yamada, Susumu Nishio, Yuta Torii, Yukina Hirata, Hiromitsu Seno, Yoshihito Saijo, Takayuki Ise, Koji Yamaguchi, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata
BACKGROUND: The projected aortic valve area (AVAproj) at a normal transvalvular flow rate using dobutamine is helpful to determine the actual severity of aortic stenosis (AS) and to predict risk of adverse events in low-gradient AS cases with unclear surgical indication. Our study aimed to identify the independent and incremental value of preload stress echocardiography-derived AVAproj to predict outcomes in patients with preserved ejection fraction and low-gradient AS. METHODS AND RESULTS: We prospectively performed echocardiographic studies in 79 patients with low-gradient AS (age, 77±7 years; 30% men) with preload stress echocardiography using leg positive pressure...
October 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28971535/combined-morphological-immunohistochemical-and-genetic-analyses-of-medulloepithelioma-in-the-posterior-cranial-fossa
#11
Kosuke Kusakabe, Shohei Kohno, Akihiro Inoue, Toshimoto Seno, Sachiko Yonezawa, Kyoko Moritani, Yosuke Mizuno, Mie Kurata, Riko Kitazawa, Hisamichi Tauchi, Hideaki Watanabe, Shinji Iwata, Junko Hirato, Takeharu Kunieda
Medulloepithelioma is a rare and highly malignant primitive neuroectodermal tumor that usually occurs in childhood. The diagnosis of this entity required only morphological analysis until the World Health Organization classification of central nervous system (CNS) tumors was revised, and now genetic analysis is necessary. We report a case of medulloepithelioma in the posterior cranial fossa that was diagnosed by both morphological and genetic analyses based on this classification. A 10-month-old girl was admitted to our hospital with consciousness disturbance and vomiting...
October 3, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28951464/proliferating-epcam-positive-ductal-cells-in-the-inflamed-liver-give-rise-to-hepatocellular-carcinoma
#12
Tomonori Matsumoto, Atsushi Takai, Yuji Eso, Kazuo Kinoshita, Toshiaki Manabe, Hiroshi Seno, Tsutomu Chiba, Hiroyuki Marusawa
Hepatocellular carcinoma (HCC) originates from regenerating liver cells with genetic alterations in chronically inflamed liver. Ductal cells and hepatocytes proliferate for liver regeneration, and proliferating ductal cells (PDC) derived from bile ductules have long been considered putative liver stem/progenitor cells and candidate cellular origins of HCC. The potential of PDC as tumor-originating cells, however, remains controversial in contrast to accumulating evidence that HCC originates from hepatocytes...
September 26, 2017: Cancer Research
https://www.readbyqxmd.com/read/28946623/practical-liposomal-formulation-for-taxanes-with-polyethoxylated-castor-oil-and-ethanol-with-complete-encapsulation-efficiency-and-high-loading-efficiency
#13
Tsukasa Shigehiro, Junko Masuda, Shoki Saito, Apriliana C Khayrani, Kazumasa Jinno, Akimasa Seno, Arun Vaidyanath, Akifumi Mizutani, Tomonari Kasai, Hiroshi Murakami, Ayano Satoh, Tetsuya Ito, Hiroki Hamada, Yuhki Seno, Tadakatsu Mandai, Masaharu Seno
Taxanes including paclitaxel and docetaxel are effective anticancer agents preferably sufficient for liposomal drug delivery. However, the encapsulation of these drugs with effective amounts into conventional liposomes is difficult due to their high hydrophobicity. Therefore, an effective encapsulation strategy for liposomal taxanes has been eagerly anticipated. In this study, the mixture of polyethoxylated castor oil (Cremophor EL) and ethanol containing phosphate buffered saline termed as CEP was employed as a solvent of the inner hydrophilic core of liposomes where taxanes should be incorporated...
September 23, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28919422/over-expression-of-ppar%C3%AE-in-obese-mice-adipose-tissue-improves-insulin-sensitivity
#14
Haruya Takahashi, Kohei Sanada, Hiroyuki Nagai, Yongjia Li, Yumeko Aoki, Takeshi Ara, Shigeto Seno, Hideo Matsuda, Rina Yu, Teruo Kawada, Tsuyoshi Goto
Peroxisome proliferator-activated receptor α (PPARα) is important in the regulation of lipid metabolism and expressed at high levels in the liver. Although PPARα is also expressed in adipose tissue, little is known about the relationship between its activation and the regulation of glucose metabolism. In this study, we developed adipose tissue specific PPARα over-expression (OE) mice. Metabolomics and insulin tolerance tests showed that OE induces branched-chain amino acid (BCAA) profile and improvement of insulin sensitivity...
November 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28877645/bone-marrow-cavity-segmentation-using-graph-cuts-with-wavelet-based-texture-feature
#15
Hironori Shigeta, Tomohiro Mashita, Junichi Kikuta, Shigeto Seno, Haruo Takemura, Masaru Ishii, Hideo Matsuda
Emerging bioimaging technologies enable us to capture various dynamic cellular activities [Formula: see text]. As large amounts of data are obtained these days and it is becoming unrealistic to manually process massive number of images, automatic analysis methods are required. One of the issues for automatic image segmentation is that image-taking conditions are variable. Thus, commonly, many manual inputs are required according to each image. In this paper, we propose a bone marrow cavity (BMC) segmentation method for bone images as BMC is considered to be related to the mechanism of bone remodeling, osteoporosis, and so on...
October 2017: Journal of Bioinformatics and Computational Biology
https://www.readbyqxmd.com/read/28876532/successful-treatment-with-doxorubicin-and-ifosfamide-for-mediastinal-malignant-peripheral-nerve-sheath-tumor-with-loss-of-h3k27me3-expression
#16
Noriko Seno, Toshirou Fukushima, Daisuke Gomi, Takashi Kobayashi, Nodoka Sekiguchi, Hidehiro Matsushita, Takesumi Ozawa, Yoshiko Tsukahara, Keiko Mamiya, Tomonobu Koizumi, Kenji Sano
Malignant peripheral nerve sheath tumor (MPNST) in the thorax is an extremely rare disease, and half of all cases of MPNST are associated with neurofibromatosis type I. Sporadic intrathoracic MPNST is difficult to diagnose and treat. Because of the rarity of intrathoracic MPNST, the optimal method of diagnosis and the efficacy of chemotherapy are unknown. Herein, we present a case of inoperable mediastinal MPNST, in which the diagnosis was immunohistochemically made by the loss of H3K27me3 expression in a transbronchial needle biopsy specimen...
November 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28862740/dynamics-of-m1-macrophages-in-oral-mucosal-lesions-during-the-development-of-acute-graft-versus-host-disease-in-rats
#17
K Seno, M Yasunaga, H Kajiya, K Izaki-Hagio, H Morita, M Yoneda, T Hirofuji, J Ohno
The role of macrophage infiltrates in oral mucosal acute graft-versus-host disease (AGVHD) remains unclear, although clinical studies suggest that macrophage infiltration correlates directly with the severity of AGVHD. In this study, we investigated the role of M1 macrophage infiltration in the oral mucosa of rats with AGVHD. Lewis rat spleen cells were injected into (Lewis × Brown Norway) F1 rats to induce systemic GVHD. Tongue samples were evaluated using histology, immunohistochemistry, dual immunofluorescence, real-time reverse transcription-polymerase chain reaction, Transwell migration assays and Stamper-Woodruff binding assays...
December 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28845587/hepatobiliary-and-pancreatic-granulomatous-hepatitis-due-to-disseminated-bacillus-calmette-gu%C3%A3-rin-disease
#18
Y Eso, A Takai, S Arasawa, Y Ueda, H Seno
No abstract text is available yet for this article.
September 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28816728/lipid-deposition-on-contact-lenses-when-using-contemporary-care-solutions
#19
RANDOMIZED CONTROLLED TRIAL
Negar Babaei Omali, Mark Lada, Carol Lakkis, Philip B Morgan, Jason J Nichols, Lakshman N Subbaraman, Lyndon W Jones
SIGNIFICANCE: There remains only a small amount of data from human studies demonstrating the effect of contact lens/lens care solution combinations on the deposition of lipids. Therefore, information on the degree to which modern materials deposit lipids when used with contemporary care solutions would be valuable. PURPOSE: The present study aims to determine the effect of lens care system combinations on levels of total lipid, cholesterol, and cholesteryl esters extracted from three different contact lenses (CLs) when used with four contemporary care systems...
September 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28790215/-a-case-of-ruptured-distal-anterior-choroidal-artery-aneurysm-associated-with-a-twig-like-middle-cerebral-artery-treated-with-single-stage-aneurysm-clipping-and-sta-mca-double-anastomoses-in-the-acute-phase
#20
Toshimoto Seno, Kanehisa Kohno, Hideo Tanaka, Shinji Iwata, Shinya Fukumoto, Haruhisa Ichikawa, Noriyuki Fumoto, Akihiro Inoue, Saya Ozaki, Yawara Nakamura, Shohei Kohno, Shiro Ohue
We report the case of a patient who has progressed well over 5 years following single-stage aneurysm clipping and superficial temporal artery-middle cerebral artery(STA-MCA)double anastomoses in the acute phase, for a ruptured distal anterior choroidal artery(AChA)aneurysm accompanied by a twig-like MCA. The patient was a 49-year-old female who developed a sudden severe headache and disturbance of consciousness due to subarachnoid hemorrhage and intraventricular hemorrhage(IVH). Cerebral angiography showed a right twig-like MCA associated with an abnormal vascular network and a ruptured aneurysm in the distal AChA...
August 2017: No Shinkei Geka. Neurological Surgery
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