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https://www.readbyqxmd.com/read/28108953/predictors-of-early-restenosis-after-intracardiac-echocardiography-guided-antegrade-balloon-aortic-valvuloplasty-in-high-risk-or-inoperable-patients
#1
Shinobu Hosokawa, Yoshikazu Hiasa, Akiho Seno, Tatuo Yasuoka, Tomoko Izumi, Riyo Ogura
Antegrade balloon aortic valvuloplasty (BAV) may be more effective than retrograde BAV. However, early restenosis is found inconstantly within three months after BAV. To evaluate the factor of ER after intracardiac echocardiogram (ICE) guided Antegrade BAV, fifty patients with severe aortic stenosis (AS) underwent BAV procedures with ICE. ER was defined as mean aortic valve pressure gradient (PG) >40 mmHg. During one-year follow-up period, 6 patients died and 2 patients underwent aortic valve replacement...
January 20, 2017: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/28063995/activation-of-tnf-%C3%AE-aid-axis-and-co-inhibitory-signals-in-coordination-with-th1-type-immunity-in-a-mouse-model-recapitulating-hepatitis-b
#2
Tomonori Matsumoto, Ken Takahashi, Tadashi Inuzuka, Soo Ki Kim, Tomoaki Kurosaki, Shigeru Kawakami, Tsutomu Chiba, Hiroshi Seno, Hiroyuki Marusawa
Hepatitis B virus (HBV) infection evokes host immune responses that primarily determine the outcome of HBV infection and the clinical features of HBV-associated liver disease. The precise mechanisms by which host factors restrict HBV replication, however, are poorly understood due to the lack of useful animal models that recapitulate immune responses to HBV. Here, we performed comprehensive immunologic gene expression profiling of the liver of a mouse model recapitulating anti-HBV immune response using a high sensitivity direct digital counting system...
January 5, 2017: Antiviral Research
https://www.readbyqxmd.com/read/27966657/modeling-quorum-sensing-trade-offs-between-bacterial-cell-density-and-system-extension-from-open-boundaries
#3
Mattia Marenda, Marina Zanardo, Antonio Trovato, Flavio Seno, Andrea Squartini
Bacterial communities undergo collective behavioural switches upon producing and sensing diffusible signal molecules; a mechanism referred to as Quorum Sensing (QS). Exemplarily, biofilm organic matrices are built concertedly by bacteria in several environments. QS scope in bacterial ecology has been debated for over 20 years. Different perspectives counterpose the role of density reporter for populations to that of local environment diffusivity probe for individual cells. Here we devise a model system where tubes of different heights contain matrix-embedded producers and sensors...
December 14, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27939219/induced-quiescence-of-lgr5-stem-cells-in-intestinal-organoids-enables-differentiation-of-hormone-producing-enteroendocrine-cells
#4
Onur Basak, Joep Beumer, Kay Wiebrands, Hiroshi Seno, Alexander van Oudenaarden, Hans Clevers
Lgr5+ adult intestinal stem cells are highly proliferative throughout life. Single Lgr5+ stem cells can be cultured into three-dimensional organoids containing all intestinal epithelial cell types at near-normal ratios. Conditions to generate the main cell types (enterocyte, goblet cells, Paneth cells, and M cells) are well established, but signals to induce the spectrum of hormone-producing enteroendocrine cells (EECs) have remained elusive. Here, we induce Lgr5+ stem cell quiescence in vitro by blocking epidermal growth factor receptor (EGFR) or mitogen-associated protein kinase (MAPK) signaling pathways in organoids and show that their quiescent state is readily reverted...
November 17, 2016: Cell Stem Cell
https://www.readbyqxmd.com/read/27921121/a%C3%A2-4d-ultrasound-real-time-tracking-system-for-external-beam-radiotherapy-of-upper-abdominal-lesions-under-breath-hold
#5
Dwi Seno Kuncoro Sihono, Lena Vogel, Christel Weiß, Johannes Thölking, Frederik Wenz, Frank Lohr, Judit Boda-Heggemann, Hansjörg Wertz
BACKGROUND AND PURPOSE: To evaluate a novel four-dimensional (4D) ultrasound (US) tracking system for external beam radiotherapy of upper abdominal lesions under computer-controlled deep-inspiration breath-hold (DIBH). MATERIALS AND METHODS: The tracking accuracy of the research 4D US system was evaluated using two motion phantoms programmed with sinusoidal and breathing patterns to simulate free breathing and DIBH. Clinical performance was evaluated with five healthy volunteers...
December 5, 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/27919525/current-and-potential-cyber-attacks-on-medical-journals-guidelines-for-improving-security
#6
REVIEW
Mehdi Dadkhah, Seyed Amin Hosseini Seno, Glenn Borchardt
At the moment, scholarly publishing is faced with much academic misconduct and threats such as predatory journals, hijacked journals, phishing, and other scams. In response, we have been discussing this misconduct and trying to increase the awareness of researchers, but it seems that there is a lack of research that presents guidelines for editors to help them protect themselves against these threats. It seems that information security is missing in some parts of scholarly publishing that particularly involves medical journals...
December 3, 2016: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/27889230/anticancer-effects-of-novel-thalidomide-analogs-in-a549-cells-through-inhibition-of-vascular-endothelial-growth-factor-and-matrix-metalloproteinase-2
#7
Bishoy El-Aarag, Tomonari Kasai, Junko Masuda, Hussein Agwa, Magdy Zahran, Masaharu Seno
Lung cancer is one of the major causes of cancer-related mortality worldwide, and non-small-cell lung cancer is the most common form of lung cancer. Several studies had shown that thalidomide has potential for prevention and therapy of cancer. Therefore, the current study aimed to investigate the antitumor effects of two novel thalidomide analogs in human lung cancer A549 cells. The antiproliferative, antimigratory, and apoptotic effects in A549 cells induced by thalidomide analogs were examined. In addition, their effects on the expression of mRNAs encoding vascular endothelial growth factor165 (VEGF165) and matrix metalloproteinase-2 (MMP-2) were evaluated...
January 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27829596/involvement-of-gene-abnormalities-in-the-development-of-digestive-diseases
#8
Tsutomu Chiba, Hiroshi Seno
No abstract text is available yet for this article.
2016: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/27725898/ipsc-derived-cancer-stem-cells-provide-a-model-of-tumor-vasculature
#9
Marta Prieto-Vila, Ting Yan, Anna Sanchez Calle, Neha Nair, Laura Hurley, Tomonari Kasai, Hiroki Kakuta, Junko Masuda, Hiroshi Murakami, Akifumi Mizutani, Masaharu Seno
To grow beyond a size of approximately 1-2 mm(3), tumor cells activate many processes to develop blood vasculature. Growing evidences indicate that the formation of the tumor vascular network is very complex, and is not restricted to angiogenesis. Cancer cell-derived tumor vasculatures have been recently described. Among them, endothelial differentiation of tumor cells have been directly related to cancer stem cells, which are cells within a tumor that possess the capacity to self-renew, and to exhibit multipotential heterogeneous lineages of cancer cells...
2016: American Journal of Cancer Research
https://www.readbyqxmd.com/read/27695924/features-of-human-autologous-hamstring-graft-elongation-after-pre-tensioning-in-anterior-cruciate-ligament-reconstruction
#10
Masataka Fujii, Takayuki Furumatsu, Shinichi Miyazawa, Takaaki Tanaka, Hiroto Inoue, Yuya Kodama, Kenji Masuda, Noritaka Seno, Toshifumi Ozaki
PURPOSE: Precise pre-tensioning protocol of the graft has not been determined in anterior cruciate ligament (ACL) reconstruction. The aims of this study are to measure the human autologous graft elongation, and to reveal what portion of the graft elongated greater after pre-tensioning in ACL reconstruction. METHODS: Twenty-four hamstring tendon grafts which were harvested from patients were included. A continuous load of 150 N was applied to the graft twice for 30 seconds each (150 N-1 minute), and the same loading was repeatedly applied (150 N-2 minute)...
September 30, 2016: International Orthopaedics
https://www.readbyqxmd.com/read/27665160/clinical-utility-of-longitudinal-strain-to-predict-functional-recovery-in-patients-with%C3%A2-tachyarrhythmia-and-reduced-lvef
#11
Kenya Kusunose, Yuta Torii, Hirotsugu Yamada, Susumu Nishio, Yukina Hirata, Hiromitsu Seno, Yoshihito Saijo, Takayuki Ise, Koji Yamaguchi, Takeshi Tobiume, Shusuke Yagi, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata
OBJECTIVES: This study sought to assess the time course of presumptive tachycardia-induced cardiomyopathy and the predictors of left ventricular (LV) functional recovery in such patients. BACKGROUND: Tachycardia-induced cardiomyopathy is a potentially reversible cardiomyopathy with effective treatment of the tachyarrhythmia. However, cases without improvement of LV systolic function were found occasionally. The diagnosis of tachycardia-induced cardiomyopathy can be challenging, and the role of echocardiographic imaging in the prediction of LV functional recovery is limited...
September 16, 2016: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27664550/central-nervous-system-infection-following-allogeneic-hematopoietic-stem-cell-transplantation
#12
Ryo Hanajiri, Takeshi Kobayashi, Kosuke Yoshioka, Daisuke Watanabe, Kyoko Watakabe, Yutaka Murata, Takeshi Hagino, Yasushi Seno, Yuho Najima, Aiko Igarashi, Noriko Doki, Kazuhiko Kakihana, Hisashi Sakamaki, Kazuteru Ohashi
OBJECTIVE/BACKGROUND: Here, we described the clinical characteristics and outcomes of central nervous system (CNS) infections occurring after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in a single institution over the previous 6 years. METHODS: Charts of 353 consecutive allogeneic transplant recipients were retrospectively reviewed for CNS infection. RESULTS: A total of 17 cases of CNS infection were identified at a median of 38 days (range, 10-1028 days) after allo-HSCT...
September 17, 2016: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/27659606/linking-in-domain-swapped-protein-dimers
#13
Marco Baiesi, Enzo Orlandini, Antonio Trovato, Flavio Seno
The presence of knots has been observed in a small fraction of single-domain proteins and related to their thermodynamic and kinetic properties. The exchanging of identical structural elements, typical of domain-swapped proteins, makes such dimers suitable candidates to validate the possibility that mutual entanglement between chains may play a similar role for protein complexes. We suggest that such entanglement is captured by the linking number. This represents, for two closed curves, the number of times that each curve winds around the other...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27647418/salt-accelerates-aldosterone-induced-cardiac-remodeling-in-the-absence-of-guanylyl-cyclase-a-signaling
#14
Hitoshi Nakagawa, Satoshi Somekawa, Kenji Onoue, Takuya Kumazawa, Tomoya Ueda, Ayako Seno, Yasuki Nakada, Tomoya Nakano, Masaru Matsui, Tunenari Soeda, Satoshi Okayama, Rika Kawakami, Hiroyuki Kawata, Hiroyuki Okura, Yoshihiko Saito
AIMS: Excess sodium causes the development of cardiovascular diseases in conjunction with enhancing renin-angiotensin-aldosterone system (RAAS). Natriuretic peptides are sodium regulators and prevent pathological cardiac alterations by counteracting RAAS. However, it is unknown whether natriuretic peptides inhibit the sodium effect in adverse cardiac alterations. Here, we investigated whether excess salt intake could exacerbate cardiac remodeling in mice with impaired natriuretic peptide signaling...
November 15, 2016: Life Sciences
https://www.readbyqxmd.com/read/27623001/sonazoid-enhanced-ultrasonography-guidance-improves-the-quality-of-pathological-diagnosis-in-the-biopsy-of-focal-hepatic-lesions
#15
Yuji Eso, Atsushi Takai, Haruhiko Takeda, Tomonori Matsumoto, Minami Lee, Tadashi Inuzuka, Ken Takahashi, Yoshihide Ueda, Hiroyuki Marusawa, Hiroshi Seno
BACKGROUND/AIM: Contrast-enhanced ultrasonography (US) has improved the detection and characterization of focal hepatic lesions. Recently, the importance of obtaining high-quality samples in the biopsy of hepatic lesions has been increasing not only in the field of pathological diagnosis but also in molecular analysis for predicting the effectiveness of anticancer agents and molecular targeted drugs. We evaluated the utility of Sonazoid-enhanced ultrasonography (SEUS) in guiding percutaneous biopsy of focal hepatic lesions by comparing the results of histopathological diagnosis between B-mode US and SEUS guidance...
September 10, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27595899/potential-roles-of-the-wearable-cardioverter-defibrillator-in-acute-phase-care-of-patients-at-high-risk-of-sudden-cardiac-death-a-single-center-japanese-experience
#16
Shingo Sasaki, Yoshihiro Shoji, Yuji Ishida, Takahiko Kinjo, Yuichi Tsushima, Maiko Seno, Fumie Nishizaki, Taihei Itoh, Kei Izumiyama, Takashi Yokota, Hiroaki Yokoyama, Masahiro Yamada, Daisuke Horiuchi, Masaomi Kimura, Takumi Higuma, Hirofumi Tomita, Ken Okumura
BACKGROUND: The wearable cardioverter-defibrillator (WCD) has been expected to play a role as an effective bridge therapy to implantable cardioverter-defibrillator (ICD) implantation in patients at high risk of ventricular tachyarrhythmias (VA). Although WCD has been available since April 2014 in Japan, its usefulness remains unclear. METHODS AND RESULTS: During the early period after hospitalization, patients at high risk of VA after excluding some elderly patients were prescribed WCD...
January 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/27585567/cystoid-macular-edema-associated-with-iridocorneal-endothelial-syndrome-a-case-report
#17
Keita Suzuki, Tadashi Mizuguchi, Yui Seno, Atsuhiro Tanikawa, Masayuki Horiguchi
BACKGROUND: Iridocorneal endothelial (ICE) syndrome occurs mainly in young and middle-aged women and typically presents as a unilateral disease characterized by abnormalities of the iris and corneal endothelium. While the ICE syndrome is known to be associated with glaucoma and bullous keratopathy, to our knowledge, only two cases of ICE syndrome complicated with cystoid macular edema (CME) have been reported to date. In this paper, we report a case of ICE syndrome complicated with CME treated at our institution...
September 1, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27581677/thrombectomy-and-catheter-directed-thrombolysis-combined-with-antithrombin-concentrate-for-treatment-of-antithrombin-deficiency-complicated-by-acute-deep-vein-thrombosis-that-is-refractory-to-anticoagulation
#18
Hirofumi Maeba, Takeshi Seno, Ichiro Shiojima
A 22-year-old male was admitted to our hospital with deep vein thrombosis that was complicated by antithrombin deficiency. This deficiency was refractory to anticoagulation therapy. Although catheter-directed thrombolysis could not reperfuse the total occlusion in the left deep vein, a combination of thrombectomy, catheter-directed thrombolysis, and antithrombin concentrate treatment was able to dissolve the clots and ameliorate the blood flow into the left deep vein. Antithrombin concentrate administration would be effective in the treatment of antithrombin deficiency with medical refractory deep vein thrombosis...
September 28, 2016: International Heart Journal
https://www.readbyqxmd.com/read/27559294/characterization-of-gene-expression-patterns-among-artificially-developed-cancer-stem-cells-using-spherical-self-organizing-map
#19
Akimasa Seno, Tomonari Kasai, Masashi Ikeda, Arun Vaidyanath, Junko Masuda, Akifumi Mizutani, Hiroshi Murakami, Tetsuya Ishikawa, Masaharu Seno
We performed gene expression microarray analysis coupled with spherical self-organizing map (sSOM) for artificially developed cancer stem cells (CSCs). The CSCs were developed from human induced pluripotent stem cells (hiPSCs) with the conditioned media of cancer cell lines, whereas the CSCs were induced from primary cell culture of human cancer tissues with defined factors (OCT3/4, SOX2, and KLF4). These cells commonly expressed human embryonic stem cell (hESC)/hiPSC-specific genes (POU5F1, SOX2, NANOG, LIN28, and SALL4) at a level equivalent to those of control hiPSC 201B7...
2016: Cancer Informatics
https://www.readbyqxmd.com/read/27510977/brg1-plays-an-essential-role-in-development-and-homeostasis-of-the-duodenum-through-regulation-of-notch-signaling
#20
Yutaka Takada, Akihisa Fukuda, Tsutomu Chiba, Hiroshi Seno
Brg1, a core subunit of the SWI/SNF chromatin remodeling complex, is essential for development and homeostasis of various organs. However, the functional role of Brg1 in intestinal development and homeostasis, and the underlying molecular mechanism, remain unknown. We found that deletion of Brg1 in the mouse intestine resulted in growth impairment and early death associated with abnormal crypt-villous formation, skewed differentiation into secretory lineage cells, markedly increased apoptosis, and stem cell loss in the duodenum...
October 1, 2016: Development
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