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https://www.readbyqxmd.com/read/28424559/evidence-of-both-systemic-inflammation-and-neuroinflammation-in-fibromyalgia-patients-as-assessed-by-a-multiplex-protein-panel-applied-to-the-cerebrospinal-fluid-and-to-plasma
#1
Emmanuel Bäckryd, Lars Tanum, Anne-Li Lind, Anders Larsson, Torsten Gordh
In addition to central hyperexcitability and impaired top-down modulation, chronic inflammation probably plays a role in the pathophysiology of fibromyalgia (FM). Indeed, on the basis of both animal experiments and human studies involving the analysis of cytokines and other inflammation-related proteins in different body fluids, neuroinflammatory mechanisms are considered to be central to the pathophysiology of many chronic pain conditions. However, concerning FM, previous human plasma/serum and/or cerebrospinal fluid (CSF) cytokine studies have looked only at a few predetermined cytokine candidates...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28411771/psychocutaneous-disease-clinical-perspectives
#2
REVIEW
Helena Kuhn, Constance Mennella, Michelle Magid, Caroline Stamu-O'Brien, George Kroumpouzos
Psychocutaneous disease, defined in this review as primary psychiatric disease with skin manifestations, is commonly encountered in dermatology. Dermatologists can play an important role in the management of psychocutaneous disease because patients visit dermatology for treatment of their skin problems but often refuse psychiatric intervention. This review describes common psychocutaneous syndromes, including delusional, factitious, obsessive-compulsive and related, and eating disorders, as well as psychogenic pruritus, cutaneous sensory (pain) syndromes, posttraumatic stress disorder, and sleep-wake disorders...
May 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28252439/informational-stress-as-a-depression-inducing-factor-experimental-study
#3
T Matitaishvili, T Domianidze, G Burdjanadze, D Nadareishvili, M Khananashvili
Chronic psychogenic stress represents the major initiating agent of psychoneural diseases including depression. We used informational stress model for the purpose of modelling chronic psychogenic stress and depression. The aim of the research was to study behavior of dominant and submissive rats at different stages of informational stress and during depression state. In order to study anxiety and depressive behavior of rats we used "forced swim", "elevated cross maze" and "open-field" tests. The obtained results showed that chronic stressing procedure performed on rats by using the mentioned "informational" stress model led to the development of depression both in dominant and submissive rats...
January 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28246588/intermittent-facial-spasms-as-the-presenting-sign-of-a-recurrent-pleomorphic-adenoma
#4
Rosalie A Machado, Sami P Moubayed, Azita Khorsandi, Juan C Hernandez-Prera, Mark L Urken
The intimate anatomical relationship of the facial nerve to the parotid parenchyma has a significant influence on the presenting signs and symptoms, diagnosis and treatment of parotid neoplasms. However, to our knowledge, hyperactivity of this nerve, presenting as facial spasm, has never been described as the presenting sign or symptom of a parotid malignancy. We report a case of carcinoma arising in a recurrent pleomorphic adenoma of the left parotid gland (i.e., carcinoma ex pleomorphic adenoma) that presented with hemifacial spasms...
February 10, 2017: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28124436/normal-sensorimotor-plasticity-in-complex-regional-pain-syndrome-with-fixed-posture-of-the-hand
#5
Francesca Morgante, Antonino Naro, Carmen Terranova, Margherita Russo, Vincenzo Rizzo, Giovanni Risitano, Paolo Girlanda, Angelo Quartarone
BACKGROUND: Movement disorders associated with complex regional pain syndrome type I have been a subject of controversy over the last 10 years regarding their nature and pathophysiology, with an intense debate about the functional (psychogenic) nature of this disorder. The aim of this study was to test sensorimotor plasticity and cortical excitability in patients with complex regional pain syndrome type I who developed a fixed posture of the hand. METHODS: Ten patients with complex regional pain syndrome type I in the right upper limb and a fixed posture of the hand (disease duration less than 24 months) and 10 age-matched healthy subjects were enrolled...
January 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28057164/role-of-pregabalin-in-management-of-pruritus-a-literature-review
#6
Nazanin Foroutan, Naemeh Nikvarz
Pruritus can be one of the distressing symptoms of many dermatologic, systemic, neurologic or psychiatric disorders. In each case, the origin of itch is in the skin and/or the nervous system. Involvement of the nervous system causes neurogenic, psychogenic or neuropathic itch. Itch sensation is transferred to the central nervous system via unmyelinated C-type nerve fibers, and many mediators and receptors engage in the its induction and transmission. Also it has been demonstrated that there are similarities and interactions between neurotransmitters and pathways of pain and itch sensation...
October 2016: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27989331/juvenile-fibromyalgia-a-primary-pain-or-pain-processing-disorder
#7
REVIEW
Lawrence Zemel, Peter R Blier
Juvenile fibromyalgia (JFM), a chronic disorder of widespread musculoskeletal pain in combination with autonomic, sensory, and cognitive dysfunction, is responsible for considerable morbidity and impaired quality of life in affected patients and their families. Historically, fibromyalgia has been incorrectly characterized as a psychosomatic or psychogenic disorder, but new understanding of the science of pain has demonstrated unambiguously that it is an organic disorder of the pain processing system itself...
August 2016: Seminars in Pediatric Neurology
https://www.readbyqxmd.com/read/27883293/psychological-mislabeling-of-chronic-pain-lessons-from-migraine-in-the-20th-century
#8
Howard B Pikoff
Starting with Freud, psychoanalytically oriented practitioners described a complex of unconscious conflicts, desires and personality traits they believed to be the primary cause of a wide range of medical disorders. This was the psychogenic model. With the advance of basic research and pharmacotherapy, the psychogenic model was gradually replaced by a biopsychobehavioral model. This model treats chronic pain as a biologically based disorder that can be influenced by psychological factors and lifestyle. The present paper argues that many patients with chronic pain may not be significantly impacted by psychological factors, and that for those who are, cognitive-behavioral therapy is the treatment of choice...
March 2017: Pain Management
https://www.readbyqxmd.com/read/27872029/association-between-infertility-and-sexual-dysfunction-in-men-and-women
#9
REVIEW
Michael H Berger, Marisa Messore, Alexander W Pastuszak, Ranjith Ramasamy
INTRODUCTION: The relation between infertility and sexual dysfunction can be reciprocal. Causes of sexual dysfunction that affect fertility include erectile dysfunction, Peyronie's disease (abnormal penile curvature), low libido, ejaculatory disorders in men, and genito-pelvic pain/penetration disorder (GPPPD) and low sexual desire in women. AIM: To review the association between infertility and sexual dysfunction and discuss current management strategies to address sexual disorders in couples with infertility...
October 2016: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/27719868/factitious-disorders-and-malingering-in-relation-to-functional-neurologic-disorders
#10
REVIEW
C Bass, P Halligan
Interest in malingering has grown in recent years, and is reflected in the exponential increase in academic publications since 1990. Although malingering is more commonly detected in medicolegal practice, it is not an all-or-nothing presentation and moreover can vary in the extent of presentation. As a nonmedical disorder, the challenge for clinical practice remains that malingering by definition is intentional and deliberate. As such, clinical skills alone are often insufficient to detect it and we describe psychometric tests such as symptom validity tests and relevant nonmedical investigations...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27719863/urologic-symptoms-and-functional-neurologic-disorders
#11
REVIEW
I Hoeritzauer, V Phé, J N Panicker
The term functional urologic disorders covers a wide range of conditions related broadly to altered function rather than structure of the lower urinary tract, mainly of impaired urine voiding or storage. Confusingly, for a neurologic readership, these disorders of function may often be due to a urologic, gynecologic, or neurologic cause. However, there is a subset of functional urologic disorders where the cause remains uncertain and, in this chapter, we describe the clinical features of these disorders in turn: psychogenic urinary retention; Fowler's syndrome; paruresis (shy-bladder syndrome); dysfunctional voiding; idiopathic overactive bladder, and interstitial cystitis/bladder pain syndrome...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27719852/functional-coma
#12
REVIEW
L Ludwig, L McWhirter, S Williams, C Derry, J Stone
Functional coma - here defined as a prolonged motionless dissociative attack with absent or reduced response to external stimuli - is a relatively rare presentation. In this chapter we examine a wide range of terms used to describe states of unresponsiveness in which psychologic factors are relevant to etiology, such as depressive stupor, catatonia, nonepileptic "pseudostatus," and factitious disorders, and discuss the place of functional or psychogenic coma among these. Historically, diagnosis of functional coma has sometimes been reached after prolonged investigation and exclusion of other diagnoses...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27719847/functional-sensory-symptoms
#13
REVIEW
J Stone, M Vermeulen
Functional (psychogenic) sensory symptoms are those in which the patient genuinely experiences alteration or absence of normal sensation in the absence of neurologic disease. The hallmark of functional sensory symptoms is the presence of internal inconsistency revealing a pattern of symptoms governed by abnormally focused attention. In this chapter we review the history of this area, different clinical presentations, diagnosis (including sensitivity of diagnostic tests), treatment, experimental studies, and prognosis...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27667488/-clinical-features-and-treatment-of-hashimoto-encephalopathy
#14
Yoshimitsu Maki, Hiroshi Takashima
Hashimoto encephalopathy (HE) is characterized by heterogeneous neurological symptoms. HE is diagnosed based on three criteria-the presence of antithyroid antibodies, neurological symptoms from the cerebrum and/or cerebellum, and a positive response to immunotherapy. We clinically analyzed 18 patients (3 men, 15 women; age range, 38-81years) diagnosed with HE in our hospital from May 2013 to January 2016. Eleven patients showed sensory abnormalities such as strong pain, deep muscle pain, dysesthesia, paresthesia, or neuralgia...
September 2016: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/27664338/an-unusual-cause-of-cervical-kyphosis
#15
Mamtha S Raj, Joseph H Schwab
BACKGROUND CONTEXT: Acute fixed cervical kyphosis may be a rare presentation of conversion disorder, psychogenic dystonia, and potentially as a side effect from typical antipsychotic drugs. Haldol has been associated with acute dystonic reactions. In some cases, rigid deformities ensue. We are reporting a case of a fixed cervical kyphosis after the use of Haldol. PURPOSE: To present a case of a potential acute dystonic reaction temporally associated with Haldol ingestion leading to fixed cervical kyphosis...
February 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27583142/explaining-unexplained-pain-to-fibromyalgia-patients-finding-a-narrative-that-is-acceptable-to-patients-and-provides-a-rationale-for-evidence-based-interventions
#16
Michael E Hyland, Claire Hinton, Charlotte Hill, Ben Whalley, Rupert Cm Jones, Anthony F Davies
As the cause of fibromyalgia is controversial, communicating with patients can be challenging, particularly if the patient adopts the narrative 'I am damaged and so I need a more powerful pain killer'. Research shows that providing patients with alternative narratives can be helpful, but it remains unclear what particular narratives are most acceptable to patients and at the same time provide a rationale for evidence based psychological and exercise interventions. This article described the development of a new narrative and the written comments made about the narrative by fibromyalgia patients...
August 2016: British Journal of Pain
https://www.readbyqxmd.com/read/27453845/chest-pain-in-general-practice-frequency-management-and-results-of-encounter
#17
Thomas Frese, Jarmila Mahlmeister, Maximilian Heitzer, Hagen Sandholzer
OBJECTIVE: Chest pain is a common reason for an encounter in general practice. The present investigation was set out to characterize the consultation rate of chest pain, accompanying symptoms, frequency of diagnostic and therapeutic interventions, and results of the encounter. MATERIALS AND METHODS: Cross-sectional data were collected from randomly selected patients in the German Sächsische Epidemiologische Studie in der Allgemeinmedizin 2 (SESAM 2) and analyzed from the Dutch Transition Project...
January 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/27380782/chest-pain-prevalence-causes-and-disposition-in-the-emergency-department-of-a-regional-hospital-in-pretoria
#18
Mimi Geyser, Selma Smith
BACKGROUND: Chest pain is a common clinical syndrome. However, there is a paucity of African studies describing the causes, prevalence, aetiology, and disposition of patients with chest pain presenting in the emergency department (ED). AIM: The aim of this retrospective descriptive study was to determine the prevalence, causes, demographics, and disposition of all adult patients with the main complaint of chest pain presenting at the ED of a regional hospital in South Africa...
June 10, 2016: African Journal of Primary Health Care & Family Medicine
https://www.readbyqxmd.com/read/27355722/psychogenic-low-back-pain-and-hysterical-paralysis-in-adolescence
#19
Tsukasa Kanchiku, Yasuaki Imajo, Hidenori Suzuki, Yuichiro Yoshida, Norihiro Nishida, Toshihiko Taguchi
STUDY DESIGN: A retrospective review. OBJECTIVE: The purpose of this study was to investigate the clinical outcomes in adolescents diagnosed with psychogenic low-back pain and hysterical paralysis and to evaluate the efficacy of differential diagnosis methods. SUMMARY OF BACKGROUND DATA: The incidence of low-back pain in adolescence is similar to that in adults, but the causes of low-back pain are difficult to determine in most cases. For these patients, a definitive diagnosis of psychogenic low-back pain and hysterical paralysis as well as adequate treatment are clinically important to avoid unnecessary surgical treatment...
June 28, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27315133/ictal-pain-occurrence-clinical-features-and-underlying-etiologies
#20
Ali A Asadi-Pooya, Marjan Asadollahi, Michael R Sperling
PURPOSE: We analyzed a series of patients with ictal pain to estimate its occurrence and characterize the underlying etiologies. METHODS: We retrospectively reviewed all the long-term video-EEG reports from Jefferson Comprehensive Epilepsy Center over a 12-year period (2004-2015) for the occurrence of the term "pain" in the text body. All the extracted reports were reviewed, and patients with at least one documented episode of ictal pain in the epilepsy monitoring unit (EMU) were included in the study...
August 2016: Epilepsy & Behavior: E&B
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