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Alicia Reyes-Cerecedo, Judith Flores-Calderón, Miguel Á Villasis-Keever, José A Chávez-Barrera, Elba E Delgado-González
Background: Bile duct atresia (BVA) is a condition that causes obstruction to biliary flow, not corrected surgically, causes cirrhosis and death before 2 years of age. In Mexico from 2013 the visual colorimetric card (VVC) was incorporated for the timely detection of BVA to the National Health Card (NHC). The aim of this study was to evaluate the impact of VCT for the detection of BVA before and after the use of NHC incorporation. Methods: Ambispective, analytical observational study...
2018: Boletín Médico del Hospital Infantil de México
Suyan G R Dos Santos, Angelo A Mattos, Marcela M Guimarães, Bibiana de S Boger, Gabriela P Coral
INTRODUCTION AND AIM: Excessive alcohol consumption is a public health concern worldwide and has been associated with high mortality rates. This study aimed to determine the prevalence of alcohol consumption and its influence on the prognosis of hospitalized cirrhotic patients in a tertiary care hospital. MATERIAL AND METHODS: We reviewed the medical records of all patients with hepatic cirrosis admitted between January 2009 and December 2014, in a referral center for liver disease in southern Brazil...
April 9, 2018: Annals of Hepatology
Isabel Barrachina Martínez, Remedios Giner Durán, David Vivas-Consuelo, Antonio López Rodado, José Alberto Maldonado Segura
OBJECTIVE: Hospital costs associated with Chronic Hepatitis C (HCC) arise in the final stages of the disease. Its quantification is very helpful in order to estimate and check the burden of the disease and to make financial decisions for new antivirals. The highest costs are due to the decompensation of cirrosis. METHODS: Cross-sectional observational study of hospital costs of HCC diagnoses in the Valencian Community in 2013 (n= 4,486 hospital discharges). Information source: Minimum basic set of data/ Basic Minimum Data Set...
April 23, 2018: Revista Española de Salud Pública
Fabiano Di Marco, Giuseppina Palumbo, Silvia Terraneo, Gianluca Imeri, Elena Lesma, Nicola Sverzellati, Angela Peron, Lorenzo Gualandri, Maria Paola Canevini, Stefano Centanni
BACKGROUND: Autoimmune hepatitis/primary biliary cirrhosis overlap syndrome, lymphangioleiomyomatosis/tuberous sclerosis complex (LAM-TSC), and sarcoidosis are three rare diseases. Here we present, to the best of our knowledge, the first description of a patient with the coexistence of these three diseases. CASE PRESENTATION: A 47-year-old woman affected by LAM-TSC and primary biliary cirrosis/autoimmune hepatitis overlap syndrome. During her follow up a high resolution chest CT scan (HRTC) confirmed the presence of both multiple cysts and micronodular opacities consistent with multifocal micronodular pneumocytes hyperlasia (MMPH), and revealed multiple hilar-mediastinal symmetrical lymphadenopathies suggestive of sarcoidosis...
July 28, 2017: BMC Pulmonary Medicine
Su Jeong Lee, Hanvit Cha, Hyunjin Kim, Jin Hyup Lee, Jeen-Woo Park
Nonalcoholic fatty liver disease (NAFLD) has a high prevalence in the general population and can evolve into nonalcoholic steatohepatosis (NASH), cirrhosis, and complications such as liver failure and hepatocellular carcinoma. Recently, we reported that mitochondrial NADP+ -dependent isocitrate dehydrogenase, encoded by the IDH2, plays an important role in the regulation of redox balance and oxidative stress levels, which are tightly associated with intermediary metabolism and energy production. In the present study, we showed that in mice targeted disruption of IDH2 attenuates age-associated hepatic steatosis by the activation of p38/cJun NH2-terminal kinase (JNK) and p53, presumably induced by the elevation of mitochondrial reactive oxygen species (ROS), which in turn resulted in the suppression of hepatic lipogenesis and inflammation via the upregulation of fibroblast growth factor 21 (FGF21) and the inhibition of NFκB signaling pathways...
April 2017: Free Radical Research
E Santos, A Rodríguez, C Prieto, M J Gil, G Frühbeck, J Quiroga, J I Herrero, J Salvador
BACKGROUND: There is a high prevalence of nutritional disorders in patients with liver cirrhosis (LC). This study was designed to assess the relationships between liver function, IFG-I/IGFBP-3, nutritional status, leptin, ghrelin and glucagon in 21 patients waiting for liver transplantation (LT). METHODS: We studied 21 men aged 56±2.1 years who were on the LT list. They were classified according to Child-Pugh(CP) score from low to high liver dysfunction in CPA (n=4),CPB (n=11) and CPC (n=6)...
April 29, 2016: Anales del Sistema Sanitario de Navarra
Rania Hadayat, Attique-ur-Rehman Jehangiri, Rahid Gul, Adil Naseer Khan, Khalid Said, Asadullah Gandapur
BACKGROUND: Acute upper gastrointestinal (GI) bleeding is a common medical emergency. A common risk factor of upper GI bleeding is cirrhosis of liver, which can lead to variceal haemorrhage. 30-40% of cirrhotic patients who bleed may have non-variceal upper GI bleeding and it is frequently caused by peptic ulcers, portal gastropathy, Mallory-Weiss tear, and gastroduodenal erosions. The objective of this study was to determine the frequency of upper gastrointestinal endoscopic findings among patients presenting with upper gastrointestinal bleeding with liver cirrhosis...
April 2015: Journal of Ayub Medical College, Abbottabad: JAMC
Jose L Calleja, Juan M Pascasio, Belén Ruiz-Antorán, Francisco Gea, Rafael Bárcena, Juan R Larrubia, Ramón Pérez-Álvarez, Jose M Sousa, Manuel Romero-Gómez, Ricard Solá, Juan de la Revilla, Javier Crespo, Jose M Navarro, Juan I Arenas, Manuel Delgado, Conrado M Fernández-Rodríguez, Ramon Planas, Maria Buti, Xavier Forns
BACKGROUND & AIMS: The addition of protease inhibitors (PIs) changed the hepatitis C virus (HCV) treatment standards and improved sustained viral response (SVR) rates in patients with genotype 1 HCV infection. METHODS: Prospective, multicentre, national registry that includes naïve and treatment-experienced patients with HCV genotype 1 infection, who had bridging fibrosis or cirrhosis and were treated with triple therapy (peginterferon alfa-2a or alfa-2b, ribavirin and boceprevir) as compassionate use, and in accordance with the Summary of Product Characteristics...
January 2015: Liver International: Official Journal of the International Association for the Study of the Liver
C Sangrador Pelluz, F J Maiques Llácer, E Soler Company
PURPOSE: To know the possible differences in the toxicity profile of triple therapy with telaprevir between monoinfected and coinfected patients. METHOD: A retrospective observational study (January 2012- November 2013) of patients with HCV genotype 1, both monoinfected and coinfected with HIV, who had completed 12 weeks of treatment with telaprevir. The necessary variables were collected to characterize patients and the treatment received. The classification was made according to the toxicity criteria of the Division of AIDS v...
January 2014: Farmacia Hospitalaria
Raúl Carrillo-Esper, Ulises Carrillo-Cortes, Jorge Raúl Carrillo-Córdova, Luis Daniel Carrillo-Córdova, Carlos Alberto Carrillo-Córdova, Dulce María Carrillo-Córdova
INTRODUCTION: portal hypertension and variceal hemorrhage are common complications of hepatic cirrhosis, both associated with a high morbimortality. Portal system decompression by the placement of a transjugular intrahepatic portosystemic stented shunt, can reduce portal venus pressure and is effective controling complications of portal hypertension, like variceal hemorrhage and ascitis. The aim of this document is to describe a case of hemolytic anemia secondary to the placement of a transjugular intrahepatic portosystemic stented shunt...
March 2013: Cirugia y Cirujanos
I Păun, D Mogoş, M Păun, M Teodorescu, M Florescu, M Tenovici, G Mogoş
This paper draws attention towards 3 cases with different pathologies all of which suggesting however both clinically and by imaging means as the most likely diagnosis advanced-stage epithelial ovarian cancer since all these three postmenopausal women had been admitted to the hospital with ascites, pelvic masses and deterioration of the physical wellbeing (fatigue, decreased appetite, weight loss, pallor). Findings during exploratory laparotomy on all these three pacients included ascites (hemorragic in one case) diffuse tumorous implants throughout the abdominal and pelvic peritoneal surfaces (in two cases) and the ovarian tumour...
July 2010: Chirurgia
Laura Valeria Corredera, Maria Laura Daruich, Juan Ignacio Diaz, Eduardo Cuestas
INTRODUCTION: Primary peritonitis is rare condition in children previously healthy. It is often related to cirrosis and kidney disease or peritoneal dyalisis. The diagnosis must be made at laparotomy in the absence of intraabdominal findings and positive cultures of peritoneal fluids. MATERIALS AND METHODS: Two cases were studied. Both cases were diagnosed during surgery and had positive cultures for streptococcus pneumaniae, recovery was rapid with broad-spectrum antibiotic therapy in peritonitis caused by gram positives cocos...
2007: Revista de la Facultad de Ciencias Médicas
Agata Budkowska
Hepatitis C virus (HCV) is an enveloped, single-stranded RNA virus, belonging to the Flaviviridae family. HCV infection is a major cause of chronic hepatitis worldwide, leading to steatosis, liver cirrosis and hepatocellular carcinoma. Significant advances in understanding the mechanisms of HCV infection have been made since the development of a cell culture system reproducing the complete HCV cell cycle in vitro. HCV represents a new paradigm in interactions between the virus and its target cell, the human hepatocyte, due to the central role of lipoproteins in the HCV life cycle...
2009: Polish Journal of Microbiology
Vicens Diaz-Brito, Helder Cardoso, António Sarmento
Cirrhosis is the terminal phase of hepatic fibrosis, that leads to impaired hepatic function and blood flow. Liver cirrhosis is the final stage of many hepatic diseases characterized by chronic cellular destruction. The complications of liver cirrosis are the result of the hepatocellular lesion and portal hypertension. The most frequent complications are ascites, spontaneous bacterial peritonitis, hepatic encephalopathy, gastroesophageal varices, portal hypertensive gastropathy, hypersplenism, hepatocellular carcinoma, methabolic disorders, hepatorenal syndrome and hepatopulmonary syndrome...
March 2008: Acta Médica Portuguesa
V A Osina, T N Kuz'mina
The present article gives evidence-based recommendations for the indication, application and type of formula of enteral nutrition (EN) (oral nutrition supplements (ONS) or tube feeding (TF)) in patients with Crohn's disease (CD), ulcerative colitis (UC), short bowel syndrome (SBS), acute and chronic pancreatitis, alcoholic steatogepatitis and cirrosis. ONS and/or TF in addition to normal food is indicates in undernourished patients with CD or UC to improve nutritional status. In active CD EN is the first line therapy in children and should be used as sole therapy in adults mainly when treatment with corticosteroids is not feasible...
2007: Experimental & Clinical Gastroenterology
Joanna Pawłowska, Piotr Kaliciński, Irena Jankowska, Mikołaj Teisseyre, Joanna Teisseyre, Diana Kamińska, Paweł Nachulewicz, Małgorzata Markiewicz-Kijewska, Jerzy Socha
THE AIM: of the study was to analyse the first 102 living-related liver transplantations performed in Poland at the Children's Memorial Health Institute. MATERIAL: between November 1999 and January 2007 102 living-related liver transplantations were carried out in 101 patients. In 63 the patients the indication for liver transplantation was biliary atresia, in 7 - intrahepatic cholestasis, in 11 - acute liver failure, in 9 - hepatic tumour, in two - graft insufficiency...
April 2007: Medycyna Wieku Rozwojowego
Bin Liu, Lu-Nan Yan, Wen-Tao Wang, Bo Li, Yong Zeng, Tian-Fu Wen, Ming-Qing Xu, Jia-Yin Yang, Zhe-Yu Chen, Ji-Chun Zhao, Yu-Kui Ma, Jiang-Wen Liu, Hong Wu
AIM: To investigate the safety of adult-to-adult living donor liver transplantation (A-A LDLT) in both donors and recipients. METHODS: From January 2002 to July 2006, 50 cases of A-A LDLT were performed at West China Hospital, Sichuan University, consisting of 47 cases using right lobe graft without middle hepatic vein (MHV), and 3 cases using dual grafts (one case using two left lobe, 2 using one right lobe and one left lobe). The most common diagnoses were hepatitis B liver cirrosis, 30 (60%) cases; and hepatocellular carcinoma, 15 (30%) cases in adult recipients...
February 14, 2007: World Journal of Gastroenterology: WJG
G P Cione, G Arciero, C P De Angelis, A Marano, N Farella, C Cerrone, D Cerbone, D Parmeggiani, G Cimmino, M Perrotta, D Giglio
The primitive tumors of the liver are relatively rare in the Western countries (around the 0.7% of all the neoplasms) while they present more elevated incidence in Africa and in the South Asian East. While the hepatocellular carcinoma rises up in the 50-70% of the cases in livers cirrosis, this correlation is not valid for the form of carcinoma to departure from the learned intra and extra biliar. The etiology of the intrahepatic colangiocarcinoma (CC) stays unknown. They have stayed observe, on the other hand, of the conditions sometimes correlated to the development of the CC (Carolí morbs, ulcerative colitis, asbestosis)...
May 2005: I Supplementi di Tumori: Official Journal of Società Italiana di Cancerologia ... [et Al.]
M Rivera, J Lucero, A Guerrero, J L Márquez, R Montes, M Suñer, A Ruiz, M A Valdivia, J Mateos
Angiodysplasia is an important cause of gastrointestinal bleeding in patients with chronic renal failure. Octreotide, a long-acting synthetic somatostatin analogue that reduces splachnic blood flow have been used to treat esophageal varicose hemorrhage, but its efficacy for bleeding vascular ecstasies is awaiting support. We present three patients with chronic renal failure (two with diabetic nephropaty and the third with mesangiocapilar glomerulonephritis and hepatic cirrosis), seric creatinine 3-4,5 mg/dl, and recurrent gastrointestinal bleeding due to diffuse angiodysplasia and vascular ecstasies, diagnosed by oral endoscopy, colonoscopy and video capsule...
2005: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
L Napolitano, M Waku, N Di Bartolomeo, L Aceto, P Innocenti
The Authors report 66 cases of patients aged 75 years or older who underwent laparoscopic cholecystectomy: 28 cases presented a clinical picture of acute cholecystitis, 3 cases had associated common bile duct stones. A high percentage of patients had cardiovascular disease: 29 patients presented with cardiopaties, of these 9 cases had a history of myocardial infarction, 31 patients had artheriosclerotic hypertension, associated, in 7 patients with signs of brain ischemia. Five patients were suffering from Parkinson's disease, 7 were carriers of diabetes, 2 had liver cirrosis...
August 2004: Il Giornale di Chirurgia
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