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https://www.readbyqxmd.com/read/29166137/primary-constrained-tips-for-treating-refractory-ascites-or-variceal-bleeding-secondary-to-hepatic-cirrhosis
#1
R Rabei, S Mathesovian, J Tasse, S Madassery, B Arslan, U Turba, O Ahmed
PURPOSE: To report an initial experience using a primary constrained TIPS technique for treating cirrhotic patients with refractory ascites or variceal bleeding. METHODS: All patients undergoing primary constrained (n=9) and conventional (n=18) TIPS between July 2014 and June 2016 were retrospectively reviewed. Pre-procedure demographics, Child-Pugh (CP), MELD, and technical variables were recorded. Outcomes measured included technical and clinical success, complications, 30-day mortality, as well as necessity for TIPS revision...
November 22, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29164488/spontaneous-elimination-of-hepatitis-c-virus-infection
#2
Maciej Janiak, Kamila Caraballo Cortes, Urszula Demkow, Marek Radkowski
Hepatitis C virus (HCV) is the etiological agent of chronic hepatitis C and a major cause of liver cirrhosis and hepatocellular carcinoma. Only a minority of infected individuals can clear the virus spontaneously. The knowledge of the determinants of virus clearance would allow the development of effective methods preventing its further spread and optimizing treatment regimens. Viral factors associated with spontaneous virus clearance in the acute phase of infection, such as HCV genotype, virus heterogeneity, and the impact of viral proteins on the immune system have been characterized...
November 22, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29164400/hepatitis-c-virus-infection-among-illicit-drug-users-in-an-archipelago-of-the-amazon
#3
Fabricio Q Silva, Francisco J A Santos, Andreia P Andrade, Suzy D B Pacheco, Benedikt Fischer, João Renato R Pinho, José Alexandre R Lemos, Aldemir B Oliveira-Filho
Hepatitis C virus (HCV) infection causes acute and chronic liver disease and may lead to cirrhosis, liver failure or hepatocellular carcinoma. The behavior of illicit drug users (DUs) typically exposes them to risks of viral infection. In the Brazilian Amazon region, a number of studies have identified high rates of drug use among adolescents, and a high prevalence of HBV infection in DUs, disseminated by sexual and parenteral activities. However, the epidemiological scenario of HCV infection in the region is still poorly understood...
November 21, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29164395/primary-biliary-cholangitis-a-comprehensive-overview
#4
REVIEW
Ana Lleo, Simona Marzorati, Juan-Manuel Anaya, M Eric Gershwin
Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by biliary destruction, progressive cholestasis, and potentially liver cirrhosis. Patients develop a well-orchestrated immune reaction, both innate and adaptive, against mitochondrial antigens that specifically targets intrahepatic biliary cells. A puzzling feature of PBC is that the immune attack is predominantly organ specific, although the mitochondrial autoantigens are found in all nucleated cells. The disease results from a combination of genetic and environmental risk factors; however, the exact pathogenesis remains unclear...
November 21, 2017: Hepatology International
https://www.readbyqxmd.com/read/29164384/comparison-of-gradient-recalled-echo-and-spin-echo-echo-planar-imaging-mr-elastography-in-staging-liver-fibrosis-a-meta-analysis
#5
Yong Seek Kim, Yu Na Jang, Ji Soo Song
OBJECTIVES: To compare the diagnostic performance of gradient-recalled echo-based magnetic resonance elastography (GRE-MRE) and spin-echo echo-planar imaging-based MRE (SE-EPI-MRE) in liver fibrosis staging. METHODS: A systematic literature search was performed to identify studies involving the performance of MRE for the diagnosis of liver fibrosis. Pooled sensitivity, specificity, positive and negative likelihood ratios, the diagnostic odds ratio, and a summary receiver operating characteristic (ROC) curve were estimated by using a bivariate random effects model...
November 21, 2017: European Radiology
https://www.readbyqxmd.com/read/29163967/the-prevalence-of-pancreatic-cystic-lesions-in-patients-with-liver-cirrhosis-is-double-that-in-controls
#6
Giulia Zerboni, Gabriele Capurso, Marco Di Pietropaolo, Francesco Carbonetti, Elsa Iannicelli, Massimo Marignani, Gianfranco Delle Fave
Background and aims: Pancreatic cystic lesions (PCLs) are commonly diagnosed incidentally and are often preneoplastic. Their presence may influence the management of patients with chronic diseases such as liver cirrhosis (LC). This study evaluated the prevalence and nature of PCLs in LC patients. Methods: The images of 192 LC patients and 192 controls who underwent either computed tomography scan or nuclear magnetic resonance were reviewed for the presence and nature of PCLs...
November 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29163964/occult-liver-disease-burden-analysis-from-a-large-general-practitioners-database
#7
Andrea Martini, Elena Ceranto, Angelo Gatta, Paolo Angeli, Patrizia Pontisso
Background: Cirrhosis represents the end stage of chronic liver disease, characterized by high mortality and morbidity. The prevalence of liver disease is difficult to assess, given its clinical latency up to the late stage. Objective: We aimed to assess the prevalence of unrecognized chronic liver disease and cirrhosis using surrogate indicators from medical records of family physicians. Methods: Medical records of 139,104 subjects, collected from 99 family physicians of the Veneto region, were used...
November 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29163959/the-gut-microbiota-a-new-potential-driving-force-in-liver-cirrhosis-and-hepatocellular-carcinoma
#8
REVIEW
Marco Sanduzzi Zamparelli, Alba Rocco, Debora Compare, Gerardo Nardone
The gut microbiota has recently been recognized as a major environmental factor in the pathophysiology of many human diseases. The anatomical and function connection existing between gut and liver provides the theoretical basis to assume the liver is a major target for gut microbes. In the last decades, numerous studies reported an altered composition of gut microbiota in patients with liver cirrhosis and a progressively marked dysbiosis with worsening of the liver disease. The risk of developing hepatocellular carcinoma, the deadliest complication of liver cirrhosis, is widely variable among cirrhotic patients, thus suggesting a complexity of genetic and environmental factors implicated in hepatocarcinogenesis...
November 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29163657/a-sonographic-doppler-study-of-the-hepatic-vein-portal-vein-and-hepatic-artery-in-liver-cirrhosis-correlation-of-hepatic-hemodynamics-with-clinical-child-pugh-score-in-singapore
#9
Azizah M Afif, Jason Pik-Eu Chang, Yan Y Wang, Simin D Lau, Fuzhen Deng, Shy Y Goh, Mar K Pwint, Chin C Ooi, Nanda Venkatanarasimha, Richard Hg Lo
Objective: Liver cirrhosis has been a rising complication of chronic liver disease in Singapore. Ultrasound has been widely accepted as a non-invasive imaging modality for the evaluation of hepatic haemodynamics. This study aims to correlate the Doppler ultrasound values with the progression of liver cirrhosis to allow further understanding and possible prediction of clinical events for timely intervention. Methods: Study sample of 56 eligible patients with liver cirrhosis was divided according to their Child-Pugh clinical score into Child's A (n = 29 patients), B (n = 19 patients) and C (n = 8 patients)...
November 2017: Ultrasound: Journal of the British Medical Ultrasound Society
https://www.readbyqxmd.com/read/29162665/the-beneficial-effects-of-curcumin-in-cirrhotic-rats-with-portal-hypertension
#10
Shao-Jung Hsu, Jing-Yi Lee, Te-Yueh Lin, Yu-Hsin Hsieh, Hui-Chun Huang, Fa-Yauh Lee, Han-Chieh Lin, Ming-Chih Hou, Shou-Dong Lee
In liver cirrhosis with portal hypertension, the uneven distribution of vasoactive substances leads to increased intrahepatic vascular resistance and splanchnic vasodilatation. Angiogenesis also induces increased portal inflow and portosystemic collaterals. The collaterals may induce lethal complications such as gastroesophageal variceal hemorrhage, but the therapeutic effect of vasoconstrictors is still suboptimal due to poor collateral vasoresponsivenss. Curcumin has aroused much attention for its anti-fibrosis, vasoactive and anti-angiogenesis actions...
November 21, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29162389/is-cryptogenic-cirrhosis-different-from-nash-cirrhosis
#11
Paul J Thuluvath, Sergey Kantsevoy, Avesh J Thuluvath, Yulia Savva
BACKGROUND & AIMS: We hypothesized that patients currently diagnosed as CC have truly 'cryptogenic' liver disease, and unlikely to have evolved from NASH. METHODS: To investigate this, we compared the clinical characteristics of adults with CC (n=7,999) with NASH (n=11,302), alcohol (AC, n=21,714) and autoimmune hepatitis (AIH, n=3,447) using the UNOS database from 2002-16. We performed an age, gender and year of listing matched comparison of CC and NASH (n= 7,201 in each group), and also stratified by the presence of obesity or diabetes mellitus (DM)...
November 18, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29161790/-anticoagulation-in-patients-with-liver-cirrhosis
#12
REVIEW
Jae Youn Cheong
Cirrhotic patients have bleeding tendencies due to the lack of coagulation factors and thrombocytopenia. However, decreased levels of procoagulants are also accompanied by decreased levels of natural anticoagulants. However, there have been contrasting reports. It has been reported that patients with cirrhosis are at risk for thrombotic complications, including portal vein thrombosis and venous thromboembolism. Physicians consider active anticoagulation for prophylaxis and treatment of portal vein thrombosis and/or venous thromboembolism in cirrhotic patients with high risk of thrombosis...
November 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29159718/genetics-and-epigenetics-in-the-pathogenesis-of-primary-biliary-cholangitis
#13
REVIEW
Satoru Joshita, Takeji Umemura, Eiji Tanaka, Masao Ota
Primary biliary cholangitis (PBC) is a chronic, slowly progressive cholestatic autoimmune liver disease predominantly afflicting women. PBC is characterized by the presence of disease-specific antimitochondrial antibodies and the histological destruction of intrahepatic bile ducts, which eventually lead to cirrhosis and hepatic failure. Fortunately, ursodeoxycholic acid therapy has improved the outcome of the vast majority of PBC cases. Although the etiology of PBC has not yet been elucidated, human leukocyte antigen (HLA) class II alleles have been consistently associated with disease onset for decades...
November 20, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29159256/cirrhosis-of-liver-interference-of-serpins-in-quantification-of-serpina4-a-preliminary-study
#14
Krishna Sumanth Nallagangula, K N Shashidhar, V Lakshmaiah, C Muninarayana
Background: Cirrhosis of liver is a pathological condition, wherein functions of liver are impaired by chronic liver exploitations. Due to decrease in synthetic capacity, expressions of plasma proteins tend to decrease in blood stream. Serpins (Serine protease inhibitors) are class of plasma proteins expressed from liver with structural similarities and diverse functions. SERPINA4 (Kallistatin) is a multifunctional serpin clade A protein expressed from liver and concentration in serum is the reflection of extent of liver dysfunction...
December 2017: Pract Lab Med
https://www.readbyqxmd.com/read/29158854/current-condition-of-chronic-hepatitis-b-virus-infection-in-cuban-adults
#15
Castellanos Fernández Marlen Ivón, Dorta Guridi Zaily, Da Silva Conde-Eduardo Leda Patricia, Galbán García Enrique, Arús Soler Enrique, Martinez Pérez Yadina
Background: The reduction of the incidence of hepatitis B virus (HBV) infection in Cuba can be attributed to the effectiveness of the national immunization program. However, the number of patients with chronic HBV observed in clinical practice is not negligible. Objective: A cross-sectional study was conducted to describe the main clinical characteristics of patients with chronic hepatitis B virus infection. Methods: A total of 146 patients who had at least a 6-month history of hepatitis B surface antigen positivity were recruited between 2013 and 2015...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/29158853/diagnosis-and-treatment-of-autoimmune-liver-diseases-in-a-tertiary-referral-center-in-cuba
#16
Marlen Ivón Castellanos Fernández, Deyanira la Rosa Hernández, Diego Enrique Cabrera Eugenio, Wilson Palanca, Zaily Dorta Guridi, Licet González Fabián
Background: Autoimmune liver diseases (AILD) comprise a set of entities characterized by tissue damage as a result of the loss of self-tolerance. There are few reports of AILD from Caribbean countries. Objectives: The aim of our study was to investigate the clinical patterns, laboratory findings, and immunologic features, treatment responses, and prognoses of AILD in adult patients at a Cuban tertiary referral center. Methods: A prospective study was conducted at the National Institute of Gastroenterology in Havana, Cuba, from May 2012 to April 2016...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/29158695/pnpla3-expression-and-its-impact-on-the-liver-current-perspectives
#17
REVIEW
Francesca Virginia Bruschi, Matteo Tardelli, Thierry Claudel, Michael Trauner
A single-nucleotide polymorphism occurring in the sequence of the human patatin-like phospholipase domain-containing 3 gene (PNPLA3), known as I148M variant, is one of the best characterized and deeply investigated variants in several clinical scenarios, because of its tight correlation with increased risk for developing hepatic steatosis and more aggressive part of the disease spectrum, such as nonalcoholic steatohepatitis, advanced fibrosis and cirrhosis. Further, the I148M variant is positively associated with alcoholic liver diseases, chronic hepatitis C-related cirrhosis and hepatocellular carcinoma...
2017: Hepatic Medicine: Evidence and Research
https://www.readbyqxmd.com/read/29158186/diffusion-kurtosis-imaging-with-the-breath-hold-technique-for-staging-hepatic-fibrosis-a-preliminary-study
#18
Daisuke Yoshimaru, Toshiaki Miyati, Yuichi Suzuki, Yuhki Hamada, Nozomi Mogi, Ayumu Funaki, Ayumi Tabata, Atsuko Masunaga, Masahiko Shimada, Maki Tobari, Takayoshi Nishino
PURPOSE: To evaluate the potential of diffusion kurtosis imaging (DKI) analysis with the breath-hold technique to assess the stage or classify hepatic fibrosis. MATERIALS AND METHODS: Patients (n=67) suspected of having a disease of the hepatobiliary system examined by diffusion-weighted imaging (DWI) using a 3.0-T magnetic resonance imaging unit were enrolled in this study. To evaluate hepatic fibrosis, mean kurtosis, Mean apparent diffusion (MD) and apparent diffusion coefficient (ADC) values were compared between groups with varying fibrosis; F0-F1, F2-F3, and F4...
November 17, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29157977/cell-type-specific-pharmacological-kinase-inhibition-for-cancer-chemoprevention
#19
Manjeet Deshmukh, Shigeki Nakagawa, Takaaki Higashi, Adam Vincek, Anu Venkatesh, Marina Ruiz de Galarreta, Anna P Koh, Nicolas Goossens, Hadassa Hirschfield, C Billie Bian, Naoto Fujiwara, Atsushi Ono, Hiroki Hoshida, Mohamed El-Abtah, Noor B Ahmad, Amaia Lujambio, Roberto Sanchez, Bryan C Fuchs, Klaas Poelstra, Jai Prakash, Yujin Hoshida
Safety is prerequisite for preventive medicine, but non-toxic agents are generally ineffective as clinical chemoprevention. Here we propose a strategy overcoming this challenge by delivering molecular-targeted agent specifically to the effector cell type to achieve sufficient potency, while circumventing toxicity in the context of cancer chemoprevention. Hepatic myofibroblasts drive progressive fibrosis that results in cirrhosis and liver cancer. In a rat model of cirrhosis-driven liver cancer, a small molecule epidermal growth factor receptor inhibitor, erlotinib, was delivered specifically to myofibroblasts by a versatile nanoparticle-based system, targeting platelet-derived growth factor receptor-beta uniquely expressed on their surface in the liver...
November 17, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29157245/low-1-5-anhydroglucitol-levels-are-associated-with-long-term-cardiac-mortality-in-acute-coronary-syndrome-patients-with-hemoglobin-a1c-levels-less-than-7-0
#20
Shohei Ouchi, Kazunori Shimada, Tetsuro Miyazaki, Shuhei Takahashi, Yurina Sugita, Megumi Shimizu, Azusa Murata, Tomoyasu Kadoguchi, Takao Kato, Tatsuro Aikawa, Shoko Suda, Eiryu Sai, Masaru Hiki, Hiroshi Iwata, Takatoshi Kasai, Katsumi Miyauchi, Hiroyuki Daida
BACKGROUND: Diabetes mellitus is considered an important risk factor for cardiovascular diseases. High hemoglobin A1c (HbA1c) levels, which indicate poor glycemic control, have been associated with occurrence of cardiovascular diseases. There are few parameters which can predict cardiovascular risk in patients with well-controlled diabetes. Low 1,5-anhydroglucitol (1,5-AG) levels are considered a clinical marker of postprandial hyperglycemia. We hypothesized that low 1,5-AG levels could predict long-term mortality in acute coronary syndrome (ACS) patients with relatively low HbA1c levels...
November 21, 2017: Cardiovascular Diabetology
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