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https://www.readbyqxmd.com/read/29145285/degeneration-of-paramedian-nuclei-in-the-thalamus-induces-holmes-tremor-in-a-case-of-artery-of-percheron-infarction
#1
Tz-Shiang Wei, Chun-Sheng Hsu, Yu-Chun Lee, Shin-Tsu Chang
RATIONALE: Holmes' tremor is an uncommon neurologic disorder following brain insults, and its pathogenesis is undefined. The interruption of the dento-rubro-thalamic tract and secondary deterioration of the nigrostriatal pathway are both required to initiate Holmes' tremor. We used nuclear medicine imaging tools to analyze a patient with concurrent infarction in different zones of each side of the thalamus. Finding whether the paramedian nuclear groups of the thalamus were injured was a decisive element for developing Holmes' tremor...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29104950/-89-zr-cobalamin-pet-tracer-synthesis-cellular-uptake-and-use-for-tumor-imaging
#2
Akhila N W Kuda-Wedagedara, Jayme L Workinger, Ebba Nexo, Robert P Doyle, Nerissa Viola-Villegas
Vitamin B12, or cobalamin (Cbl), is an essential nutrient. Acquisition, transport, and cellular internalization of Cbl are dependent on specific binding proteins and associated receptors. The circulating transport protein transcobalamin (TC) promotes cellular uptake via binding to specific receptors such as CD320, a receptor upregulated in several cancer cell lines. In this study, we report the successful synthesis of (89)Zirconium-labeled Cbl that was derivatized with desferrioxamine ((89)Zr-Cbl). We document the purity of the tracer and its binding to TC compared with that of unmodified cyano-Cbl (CN-Cbl)...
October 31, 2017: ACS Omega
https://www.readbyqxmd.com/read/29068560/extremely-vivid-highly-transparent-and-ultrathin-quantum-dot-light-emitting-diodes
#3
Moon Kee Choi, Jiwoong Yang, Dong Chan Kim, Zhaohe Dai, Junhee Kim, Hyojin Seung, Vinayak S Kale, Sae Jin Sung, Chong Rae Park, Nanshu Lu, Taeghwan Hyeon, Dae-Hyeong Kim
Displaying information on transparent screens offers new opportunities in next-generation electronics, such as augmented reality devices, smart surgical glasses, and smart windows. Outstanding luminance and transparency are essential for such "see-through" displays to show vivid images over clear background view. Here transparent quantum dot light-emitting diodes (Tr-QLEDs) are reported with high brightness (bottom: ≈43 000 cd m(-2) , top: ≈30 000 cd m(-2) , total: ≈73 000 cd m(-2) at 9 V), excellent transmittance (90% at 550 nm, 84% over visible range), and an ultrathin form factor (≈2...
October 25, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29065111/identification-of-a-specific-peptide-binding-to-colon-cancer-cells-from-a-phage-displayed-peptide-library
#4
Lidan Hou, Danxi Zhu, Yu Liang, Xiaohui Tian, Lei Li, Ping Wang, Liming Zhu, Xiaoling Weng, Yingying Wang, Yue Li, Tianqi Wu, Jianhua Wang, Xiangjun Meng
BACKGROUND: New molecular probes are essential for early colon cancer diagnosis. A phage-display screening was performed to select novel binding peptides for early colon cancer imaging detection. METHODS: A human colon cancer cell line (COLO320HSR) and a normal human intestinal epithelial cell line (NCM460) were used for subtractive screening with a phage peptide library. The positive peptides were identified, and their binding capacities were confirmed by confocal immunofluorescence both in human colon cancer cells and in biopsy specimens...
October 24, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29053074/clinical-improvement-associated-with-targeted-interruption-of-the-cerebellothalamic-tract-following-mr-guided-focused-ultrasound-for-essential-tremor
#5
J Levi Chazen, Harini Sarva, Philip E Stieg, Robert J Min, Douglas J Ballon, Kane O Pryor, Paul M Riegelhaupt, Michael G Kaplitt
OBJECTIVE The objective of this study was to evaluate the utility of diffusion tensor imaging (DTI) tractography-based targeting of the dentatorubrothalamic tract (DRT) for magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy in patients with essential tremor (ET) and correlate postprocedural tract disruption with clinical outcomes. METHODS Four patients received preprocedural and immediate postprocedural DTI in addition to traditional anatomical MRI sequences for MRgFUS thalamotomy. Optimal ablation sites were selected based on the patient-specific location of the DRT as demonstrated by DTI (direct targeting) and correlated with traditional atlas-based measurements for thalamic ventral intermediate nucleus (Vim) lesioning (indirect targeting)...
October 20, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29049147/virtual-reality-model-of-the-three-dimensional-anatomy-of-the-cavernous-sinus-based-on-a-cadaveric-image-and-dissection
#6
Zeng-Hui Qian, Xu Feng, Yang Li, Ke Tang
OBJECTIVE: Studying the three-dimensional (3D) anatomy of the cavernous sinus is essential for treating lesions in this region with skull base surgeries. Cadaver dissection is a conventional method that has insurmountable flaws with regard to understanding spatial anatomy. The authors' research aimed to build an image model of the cavernous sinus region in a virtual reality system to precisely, individually and objectively elucidate the complete and local stereo-anatomy. METHODS: Computed tomography and magnetic resonance imaging scans were performed on 5 adult cadaver heads...
October 18, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28971628/comparative-three-dimensional-morphology-of-baleen-cross-sectional-profiles-and-volume-measurements-using-ct-images
#7
Megan M Jensen, Amalia H Saladrigas, Jeremy A Goldbogen
Baleen whales are obligate filter feeders, straining prey-laden seawater through racks of keratinized baleen plates. Despite the importance of baleen to the ecology and natural history of these animals, relatively little work has been done on baleen morphology, particularly with regard to the three-dimensional morphology and structure of baleen. We used computed tomography (CT) scanning to take 3D images of six baleen specimens representing five species, including three complete racks. With these images, we described the three-dimensional shape of the baleen plates using cross-sectional profiles from within the gum tissue to the tip of the plates...
November 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28961795/improving-protein-fold-recognition-by-extracting-fold-specific-features-from-predicted-residue-residue-contacts
#8
Jianwei Zhu, Haicang Zhang, Shuai Cheng Li, Chao Wang, Lupeng Kong, Shiwei Sun, Wei-Mou Zheng, Dongbo Bu
Motivation: Accurate recognition of protein fold types is a key step for template-based prediction of protein structures. The existing approaches to fold recognition mainly exploit the features derived from alignments of query protein against templates. These approaches have been shown to be successful for fold recognition at family level, but usually failed at superfamily/fold levels. To overcome this limitation, one of the key points is to explore more structurally-informative features of proteins...
August 16, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28933331/-comparison-of-the-arthroscopic-finding-in-the-knee-joint-and-the-mri-retrospective-study
#9
K Šimeček, P Látal, J Duda, M Šimeček
PURPOSE OF THE STUDY Our retrospective study presents the comparison of the preoperative magnetic resonance imaging of the knee joint - MRI - and the arthroscopic finding - ASC. Its aim is to find out how a positive or a negative finding of MRI corresponds with the operative finding and how much the experience of radiologist contributes to the conformity. MATERIAL AND METHODS The MRI findings of knee joints treated surgically at two departments in 2013 and 2014 were assessed. The MRI was performed in a total of 470 patients who subsequently underwent an arthroscopic surgery...
2017: Acta Chirurgiae Orthopaedicae et Traumatologiae Cechoslovaca
https://www.readbyqxmd.com/read/28918435/infant-avoidance-training-alters-cellular-activation-patterns-in-prefronto-limbic-circuits-during-adult-avoidance-learning-ii-cellular-imaging-of-neurons-expressing-the-activity-regulated-cytoskeleton-associated-protein-arc-arg3-1
#10
Nicole Gröger, Anja Mannewitz, Jörg Bock, Susann Becker, Katja Guttmann, Gerd Poeggel, Katharina Braun
Positive and negative feedback learning is essential to optimize behavioral performance. We used the two-way active avoidance (TWA) task as an experimental paradigm for negative feedback learning with the aim to test the hypothesis that neuronal ensembles activate the activity-regulated cytoskeletal (Arc/Arg3.1) protein during different phases of avoidance learning and during retrieval. A variety of studies in humans and other animals revealed that the ability of aversive feedback learning emerges postnatally...
September 16, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28895470/generation-of-a-close-to-native-in-vitro-system-to-study-lung-cells-ecm-crosstalk
#11
Zuzana Garlikova, Ana Catarina Silva, Ana Rabata, David Potesil, Ivana Ihnatova, Jana Dumkova, Zuzana Koledova, Zbynek Zdrahal, Vladimir Vinarsky, Ales Hample, Perpetua Pinto-do-O, Diana S Nascimento
Extracellular matrix (ECM) is an essential component of the tissue microenvironment, actively shaping cellular behavior. In vitro culture systems are often poor in ECM constituents thus not allowing for naturally occurring cell-ECM interactions. This study reports on a straightforward and efficient method for generation of ECM scaffolds from lung tissue and its subsequent in vitro application using primary lung cells. Mouse lung tissue was subjected to decellularization with 0.2% sodium dodecyl sulfate, hypotonic solutions and DNase...
September 12, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28874149/comparison-of-computed-tomography-and-high-field-3-0%C3%A2-t-magnetic-resonance-imaging-of-age-related-variances-in-selected-equine-maxillary-cheek-teeth-and-adjacent-tissues
#12
Christin Schoppe, Maren Hellige, Karl Rohn, Bernhard Ohnesorge, Astrid Bienert-Zeit
BACKGROUND: Modern imaging techniques such as computed tomography (CT) and magnetic resonance imaging (MRI) have the advantage of producing images without superimposition. Whilst CT is a well-established technique for dental diagnostics, MRI examinations are rarely used for the evaluation of dental diseases in horses. Regarding equine endodontic therapies which are increasingly implemented, MRI could help to portray changes of the periodontal ligament and display gross pulpar anatomy...
September 6, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28835099/glutathione-sensitive-hyaluronic-acid-mercaptopurine-prodrug-linked-via-carbonyl-vinyl-sulfide-a-robust-and-cd44-targeted-nanomedicine-for-leukemia
#13
Jie Qiu, Ru Cheng, Jian Zhang, Huanli Sun, Chao Deng, Fenghua Meng, Zhiyuan Zhong
6-Mercaptopurine (6-MP) is an essential medicine used for treating leukemia in the clinics. 6-MP suffers, however, from poor water solubility, low bioavailability, and significant side effects. Here, we designed CD44-targeted glutathione-sensitive hyaluronic acid-mercaptopurine prodrug (HA-GS-MP) linked via carbonyl vinyl sulfide for safer and enhanced treatment of acute myeloid leukemia (AML). HA-GS-MP obtained with 50 kDa HA and 6-MP conjugation content of 6.9 wt % showed excellent water solubility with a hydrodynamic size of ca...
September 1, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28808784/the-history-of-optic-chiasm-from-antiquity-to-the-twentieth-century
#14
REVIEW
Claudia Florida Costea, Şerban Turliuc, Cătălin Buzdugă, Andrei Ionuţ Cucu, Gabriela Florenţa Dumitrescu, Anca Sava, Mihaela Dana Turliuc
PURPOSE: The optic chiasm is an essential structure located at the skull base that stirred over time the curiosity of anatomists, who became more and more interested in its structure and function. Through centuries, the optic chiasm was viewed as a vessel crossing, a way of transporting tears secreted by the brain to the eye, integrating images, or responsible for coordinated eye movements. The paper aims to overview the history of understanding the optic chiasm from the beginnings of antiquity to the twentieth century...
November 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28806473/flavylium-polymethine-fluorophores-for-near-and-shortwave-infrared-imaging
#15
Emily D Cosco, Justin R Caram, Oliver T Bruns, Daniel Franke, Rachael A Day, Erik P Farr, Moungi G Bawendi, Ellen M Sletten
Bright fluorophores in the near-infrared and shortwave infrared (SWIR) regions of the electromagnetic spectrum are essential for optical imaging in vivo. In this work, we utilized a 7-dimethylamino flavylium heterocycle to construct a panel of novel red-shifted polymethine dyes, with emission wavelengths from 680 to 1045 nm. Photophysical characterization revealed that the 1- and 3-methine dyes display enhanced photostability and the 5- and 7-methine dyes exhibit exceptional brightness for their respective spectral regions...
August 14, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28803829/the-vascular-niche-regulates-hematopoietic-stem-and-progenitor-cell-lodgment-and-expansion-via-klf6a-ccl25b
#16
Yuanyuan Xue, Junhua Lv, Chunxia Zhang, Lu Wang, Dongyuan Ma, Feng Liu
In mammals, hematopoietic stem and progenitor cells (HSPCs) rapidly expand in the fetal liver (FL), but the underlying mechanism remains unclear. Here, we characterize zebrafish caudal hematopoietic tissue (CHT) and identify an important cellular and molecular mechanism of HSPC expansion. Time-lapse imaging showed that HSPCs localize adjacent to vascular endothelial cells (ECs), and their migration and expansion display caudal vein-specific orientation in the CHT. RNA sequencing and functional analysis identified that an EC-expressed transcription factor, Krüppel-like factor 6a (Klf6a), is essential for the CHT niche...
August 21, 2017: Developmental Cell
https://www.readbyqxmd.com/read/28775057/localizing-the-l5-vertebra-using-nerve-morphology-on-mri-an-accurate-and-reliable-technique
#17
M E Peckham, T A Hutchins, S E Stilwill, M K Mills, B J Morrissey, E A R Joiner, R K Sanders, G J Stoddard, L M Shah
BACKGROUND AND PURPOSE: Multiple methods have been used to determine the lumbar vertebral level on MR imaging, particularly when full spine imaging is unavailable. Because postmortem studies show 95% accuracy of numbering the lumbar vertebral bodies by counting the lumbar nerve roots, attention to lumbar nerve morphology on axial MR imaging can provide numbering clues. We sought to determine whether the L5 vertebra could be accurately localized by using nerve morphology on MR imaging...
August 3, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28758913/versatility-of-pyridoxal-phosphate-as-a-coating-of-iron-oxide-nanoparticles
#18
Debora Bonvin, Ulrich J Aschauer, Jessica A M Bastiaansen, Matthias Stuber, Heinrich Hofmann, Marijana Mionić Ebersold
Pyridoxal 5'-phosphate (PLP) is the most important cofactor of vitamin B₆-dependent enzymes, which catalyses a wide range of essential body functions (e.g., metabolism) that could be exploited to specifically target highly metabolic cells, such as tumour metastatic cells. However, the use of PLP as a simultaneous coating and targeting molecule, which at once provides colloidal stability and specific biological effects has not been exploited so far. Therefore, in this work iron oxide nanoparticles (IONPs) were coated by PLP at two different pH values to tune PLP bonding (e...
July 29, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28757666/generating-an-image-that-affords-slant-perception-from-stereo-without-pictorial-cues
#19
J Galeotti, K Macdonald, J Wang, S Horvath, A Zhang, R Klatzky
This paper describes an algorithm for generating a planar image that when tilted provides stereo cues to slant, without contamination from pictorial gradients. As the stimuli derived from this image are ultimately intended for use in studies of slant perception under magnification, a further requirement is that the generated image be suitable for high-definition printing or display on a monitor. A first stage generates an image consisting of overlapping edges with sufficient density that when zoomed, edges that nearly span the original scale are replaced with newly emergent content that leaves the visible edge statistics unchanged...
January 2017: Displays
https://www.readbyqxmd.com/read/28740475/the-cognitive-information-effect-of-televised-news
#20
REVIEW
George Lăzăroiu, Aurel Pera, Ramona O Ştefănescu-Mihăilă, Sofia Bratu, Nela Mircică
The purpose of this review is to summarize the key findings which prove that the biased perceptions of viewers may provide an inaccurate image of the informational validity of televised news. The news may generate distorted recollections of what occurred in particular reported events if displayed routines influence viewers not to pay attention to the essential features of a narrative. Elaborating on Fiske and Hartley (2010), Zelizer (2010), and Gunter (2015), we indicate that the character of the news setting has altered and individuals' news consumption routines have changed in adapting to media advancements...
2017: Frontiers in Psychology
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