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https://www.readbyqxmd.com/read/29778823/toward-smart-nebulization-engineering-acoustic-airflow-to-penetrate-maxillary-sinuses-in-chronic-rhinosinusitis
#1
Shima Jowhari Moghadam, Laurent Navarro, Lara Leclerc, Sophie Hodin, Jérémie Pourchez
Treating chronic rhinosinusitis (CRS) by nebulization requires an airflow capable to deliver medication to deep target sites beyond the nasal valve. Fixed frequency acoustic airflow technology is currently available, mainly as post-surgical therapy, but still have not been able to realize the full potential of direct nose to paranasal sinuses delivery. Reported herein are the application of frequency sweep acoustic airflow and the optimization of its frequency range, sweep cycle duration and intensity. The resonant frequencies of the model's maxillary sinuses can be estimated using the Helmholtz resonator theory...
May 17, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29756407/a-prospective-study-for-treatment-of-nasal-valve-collapse-due-to-lateral-wall-insufficiency-outcomes-using-a-bioabsorbable-implant
#2
Pablo Stolovitzky, Douglas M Sidle, Randall A Ow, Nathan E Nachlas, Sam P Most
OBJECTIVE: To examine 6-month outcomes for treatment of lateral nasal wall insufficiency with a bioabsorbable implant. STUDY DESIGN: Prospective, multicenter, nonrandomized, single-blinded study. METHODS: One hundred and one patients with severe-to-extreme class of Nasal Obstruction Symptom Evaluation (NOSE) scores were enrolled at 14 U.S. clinics (September 2016-March 2017). Patients were treated with a bioabsorbable implant designed to support lateral wall, with or without concurrent septoplasty and/or turbinate reduction procedure(s)...
May 14, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29733924/thirteen-year-experience-with-universal-staphylococcus-aureus-nasal-decolonisation-prior-to-cardiac-surgery-a-quasi-experimental-study
#3
Adrien Lemaignen, Laurence Armand-Lefevre, Gabriel Birgand, Guillaume Mabileau, Isabelle Lolom, Walid Ghodbane, Pierre Dilly Marie, Patrick Nataf, Jean-Christophe Lucet
INTRODUCTION: Sternal wound infection (SWI) after cardiac surgery is a severe complication. Among preventive measures, pre-operative decolonisation of nasal carriage of Staphylococcus aureus has recently been shown to be beneficial. In this quasi-experimental study, we assessed the effect of decolonisation on the incidence of S. aureus-associated SWI during 19-year prospective surveillance. METHODS: We analysed by segmented negative binomial regression the change over time of the incidence of S...
May 4, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29707440/assessment-of-functional-rhinoplasty-with-spreader-grafting-using-acoustic-rhinomanometry-and-validated-outcome-measurements
#4
Marek A Paul, Parisa Kamali, Austin D Chen, Ahmed M S Ibrahim, Winona Wu, Babette E Becherer, Caroline Medin, Samuel J Lin
Background: Rhinoplasty is 1 of the most common aesthetic and reconstructive plastic surgical procedures performed within the United States. Yet, data on functional reconstructive open and closed rhinoplasty procedures with or without spreader graft placement are not definitive as only a few studies have examined both validated measurable objective and subjective outcomes of spreader grafting during rhinoplasty. The aim of this study was to utilize previously validated measures to assess objective, functional outcomes in patients who underwent open and closed rhinoplasty with spreader grafting...
March 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29706591/semilunar-conchal-cartilage-graft-in-saddle-nose-reconstruction
#5
I Rašić, A Košec, A Pegan
INTRODUCTION: The saddle nose deformity is easily recognized by the loss of septal support and nasal dorsal height with adverse functional and aesthetic consequences. TECHNIQUE: We treated a 50-year-old woman and a 54-year old man that presented with a moderate saddle nose deformity following a previous septorhinoplasty (female patient) and a posttraumatic severe saddle nose deformity (male patient). The patients were treated by open approach rhinoplasty under general anesthesia, and the saddle nose deformity was reconstructed with a semilunar conchal cartilage graft...
April 26, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29673851/the-use-of-allogeneic-cartilage-for-grafting-in-functional-and-reconstructive-rhinoplasty
#6
Andrew M Read-Fuller, David M Yates, Alaaaldin Radwan, Alexander M Schrodt, Richard A Finn
PURPOSE: Allogeneic cartilage grafting has multiple uses in rhinoplasty. Autogenous cartilage is frequently used in cases of nasal obstruction or reconstruction, but harvesting grafts can cause complications or might be contraindicated. Rhinoplasties of the patient with cleft might require costochondral grafts. Allogeneic rib is an effective and safe alternative to autogenous grafts, prevents complications, and obviates postoperative admission after rib harvest. MATERIALS AND METHODS: Patients who had allogeneic cartilage placed during functional or reconstructive rhinoplasty were studied from 2 institutions, including 19 who had functional rhinoplasty using allogeneic Cartiform patellar cartilage grafts and 15 patients who underwent reconstructive cleft rhinoplasty with allogeneic rib cartilage...
March 27, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29627779/low-dose-warfarin-maternal-anticoagulation-and-fetal-warfarin-syndrome
#7
Ana R Sousa, Rita Barreira, Edmundo Santos
Fetuses exposed to warfarin during pregnancy are at an increased risk of developing an embryopathy known as fetal warfarin syndrome or warfarin embryopathy. The most consistent anomalies are nasal hypoplasia and stippling of vertebrae or bony epiphyses. Management of pregnant patients on anticoagulation is challenging. Current guidelines suggest the use of warfarin if the therapeutic dose is ≤5 mg/day. We report the case of a newborn with signs of warfarin embryopathy born from a mother anticoagulated with warfarin due to mechanical mitral and aortic heart valves...
April 7, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29618857/three-component-cartilage-framework-reconstruction-for-correction-of-post-traumatic-nasal-septal-collapse
#8
Uday Bhat, Tarush Gupta, Mahesh Nair, Mayur Mantri, Mangesh Pawar, Amresh Baliarsing
Background: Post-traumatic nasal septal collapse results in flat, broad, non-projecting nose due to mid-vault collapse. These patients may have airway obstruction due to poorly supported internal valve. Traditional techniques like 'cantilever graft technique' or conventional 'L-graft technique' produce a rigid lobule as the single unit framework extends to the tip. These grafts also lack in internal valve support. Materials and Methods: Twelve patients with post-traumatic nasal septal collapse were treated with three component cartilage framework technique in the past 3 years...
September 2017: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/29605374/primary-augmentation-pharyngoplasty-with-calcium-hydroxylapatite-for-treatment-of-velopharyngeal-insufficiency-surgical-and-speech-outcomes
#9
Patrick D Munson, Alicia Ward
INTRODUCTION: Augmentation pharyngoplasty (AP) is a technique that may effectively treat velopharyngeal insufficiency (VPI), while avoiding typical short and long term surgical risks. This study seeks to determine if children with VPI treated by AP with calcium hydoxylapatite (CaHa) demonstrate clinically significant improvement in speech outcomes. METHODS: Retrospective review (2012-2016) of prospectively collected database of children with VPI, cared for at a single tertiary children's hospital...
May 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29597035/partitioning-of-dispersed-nanoparticles-in-a-realistic-nasal-passage-for-targeted-drug-delivery
#10
Jingliang Dong, Yidan Shang, Kiao Inthavong, Hak-Kim Chan, Jiyuan Tu
The complex nasal structure poses obstacles for efficient nasal drug administration beyond the nasal valve, especially when targeting the olfactory region. This study numerically detailed the naturally inhaled nanoparticle transport process from the initial releasing locations to the final deposited sites using a realistic human nasal passage. Dispersed nanoparticles at different coronal cross-sections were partitioned into multiple groups according to their final deposited locations. Results showed inhaled nanoparticles are more likely to move along the septum...
March 26, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29561482/improving-postoperative-nasal-airway-patency-in-le-fort-based-maxillofacial-trauma-patients-via-a-modified-nasal-packing-technique
#11
Amir Wolff, Gabriel F Santiago, Micah Belzberg, Omri Emodi, Chad R Gordon
INTRODUCTION: Combined mid-face and nasal apparatus trauma injuries pose a significant challenge to airway patency (AW), in the immediate postoperative setting following fracture reduction. As such, the authors describe a modified technique with the goal of maintaining a patent nasal AW, while at the same time, minimizing nasopharyngeal bleeding and nasal AW edema-which can complicate patients requiring intermaxillary fixation (IMF) in the setting of pan-facial trauma. METHODS: A modified technique was devised to assist the reconstruction surgeon in avoiding the risks associated with tracheostomy placement...
March 20, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29537996/comparative-outcomes-in-functional-rhinoplasty-with-open-vs-endonasal-spreader-graft-placement
#12
Jason Talmadge, Robin High, William Wesley Heckman
IMPORTANCE: Spreader grafts are commonly used for nasal valve stenosis. There is debate among practitioners regarding the optimal approach for spreader graft placement. OBJECTIVE: This study aimed to determine whether an endonasal spreader graft placement leads to equivalent postoperative outcomes using a standardized nasal obstruction symptom score and whether there is a significant difference in operative time between the 2 approaches. DESIGN: A retrospective review of functional rhinoplasties by a single facial plastic surgeon over a 2-year period was conducted...
May 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29516178/the-effect-of-lateral-crural-overlay-surgical-technique-on-elasticity-of-nasal-ala
#13
Saeid Atighechi, Mohammadhossein Dadgarnia, Sedighe Vaziribozorg, Zahra Jokar, Ruhollah Sadeghmanesh
INTRODUCTION: The nasal tip refinement is the most difficult stages of rhinoplasty surgery; whereas, the most important part in terms of beauty and performance is the projection refinement. Lateral crural overlay (LCO) is a common technique in rhinoplasty used to reduce nasal tip projection and increase nasal tip rotation. Given the important role of lower lateral cartilage (LLC) in the non-collapse of nasal external valve and air passage, it is necessary to evaluate the changes in nasal elasticity caused by surgery...
May 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29485888/personalized-medicine-in-nasal-delivery-the-use-of-patient-specific-administration-parameters-to-improve-nasal-drug-targeting-using-3d-printed-nasal-replica-casts
#14
Zachary N Warnken, Hugh D C Smyth, Daniel A Davis, Steve Weitman, John G Kuhn, Robert O Williams
Effective targeting of nasal spray deposition could improve local, systemic, and CNS drug delivery; however, this has proven to be difficult due to the anatomical features of the nasal cavity, including the nasal valve and turbinate structures. Furthermore, nasal cavity geometries and dimensions vary between individuals based on differences in their age, gender, and ethnicity. The effect of patient-specific administration parameters was evaluated for their ability to overcome the barriers of targeted nasal drug delivery...
April 2, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29453801/regional-deposition-of-nasal-sprays-in-adults-a-wide-ranging-computational-study
#15
Milad Kiaee, Herbert Wachtel, Michelle L Noga, Andrew R Martin, Warren H Finlay
The present work examines regional deposition within the nose for nasal sprays over a large and wide ranging parameter space by using numerical simulation. A set of 7 realistic adult nasal airway geometries was defined based on computed tomography images. Deposition in 6 regions of each nasal airway geometry (the vestibule, valve, anterior turbinate, posterior turbinate, olfactory, and nasopharynx) was determined for varying particle diameter, spray cone angle, spray release direction, particle injection speed, and particle injection location...
February 17, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29444694/reliability-and-construct-validity-of-the-ottawa-valve-collapse-scale-when-assessing-external-nasal-valve-collapse
#16
Hedyeh Ziai, James P Bonaparte
BACKGROUND: Nasal valve collapse is a common cause of nasal obstruction in otolaryngology practice. Common examination methods, such as the Cottle Maneuver and modified Cottle Maneuver are available. However, these methods are dichotomous and do not provide ordinal severity information. The Ottawa Valve Collapse Scale (OVCS) is a grading system for assessing and easily grading external nasal valve collapse in patients with a septal deviation. The primary objective was to assess the test-retest reliability and construct validity of the OVCS grading scale...
February 14, 2018: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29397128/dynamic-behaviour-of-the-soft-palate-during-nasal-positive-pressure-ventilation-under-anaesthesia-and-paralysis-comparison-between-patients-with-and-without-obstructive-sleep-disordered-breathing
#17
M Okuyama, S Kato, S Sato, J Okazaki, Y Kitamura, T Ishikawa, Y Sato, S Isono
BACKGROUND: Difficult mask ventilation is common and is known to be associated with sleep-disordered breathing (SDB). It is our hypothesis that the incidence of expiratory retropalatal (RP) airway closure (primary outcome) during nasal positive pressure ventilation (PPV) is more frequent in patients with SDB (apnea hypopnea index ≥5 h-1 ) than non-SDB subjects. METHODS: The severity of SDB was assessed before surgery using a portable sleep monitor. In anaesthetized and paralysed patients with (n=11) and without SDB (n=9), we observed the behaviour of the RP airway endoscopically during nasal PPV with the mouth closed and determined the dynamic RP closing pressure, which was defined as the highest airway pressure above which the RP airway closure was reversed...
January 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29391011/caprine-herpesvirus-2-associated-malignant-catarrhal-fever-of-captive-sika-deer-cervus-nippon-in-an-intensive-management-system
#18
Hongwei Zhu, Qingrong Huang, Xiaoliang Hu, Wenhui Chu, Jianlong Zhang, Linlin Jiang, Xin Yu, Xingxiao Zhang, Shipeng Cheng
BACKGROUND: Caprine herpesvirus 2 (CpHV-2) infection usually induces chronic malignant catarrhal fever (MCF) in sika deer (Cervus nippon), with the primary signs of weight loss, dermatitis and alopecia. CASE PRESENTATION: Here, we report a case of CpHV-2-associated acute MCF in a sika deer herd raised in an intensive management system distant to the reservoir goats. Affected deer developed clinical signs of high fever (41 °C) followed by nasal discharge and lameness...
February 1, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29381259/nasal-valve-evaluation-in-the-mexican-hispanic-mestizo-nose
#19
Elizabeth Jasso-Ramírez, Fernando Sánchez Y Béjar, Fernando Arcaute Aizpuru, Irene E Maulen Radován, Héctor de la Garza Hesles
BACKGROUND: Our aim in this study was to determine the angle of the internal nasal valve in Mexican patients with the "mestizo nose" feature and without nasal obstructive symptoms. The work was prospective, comparative, and observational in nature and included patients >14 years of age who were seen in the Otolaryngology Department at the Los Angeles Lomas Hospital between April and May 2016. METHODS: The angle of the internal nasal valve was measured in 30 patients without obstructive symptoms...
April 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29380022/nasal-alar-schwannoma-an-unusual-case-report
#20
Timothy C Blood, Thomas G Townes, Shaun C Desai
PURPOSE: To present the second known case of nasal alar schwannoma, first since 1973, with important considerations for surgical management. CASE REPORT: We present the case of a 25-year-old male with a 5-year history of progressively enlarging, non-tender, right alar mass with resultant ipsilateral nasal congestion and dyspnea secondary to nasal valve collapse. The mass was located cephalic to the mid-lateral aspect of the lower lateral crural cartilage, which extended to the pyriform aperture...
January 29, 2018: Aesthetic Plastic Surgery
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