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https://www.readbyqxmd.com/read/29226891/the-relationship-between-right-ventricular-outflow-tract-fractional-shortening-and-pulmonary-embolism-severity-index-in-acute-pulmonary-embolism
#1
Ekrem Şahan, Murat Karamanlıoğlu, Suzan Şahan, Murat Gül, Ahmet Korkmaz, Omaç Tüfekçioğlu
OBJECTIVE: Right ventricular (RV) functions are clinically important in acute pulmonary embolism (APE). Measurement of systolic function of the right ventricular outflow tract (RVOT) with echocardiography is a simple method to evaluate RV function. The aim of this study was to determine the relationship between RVOT systolic function and the Pulmonary Embolism Severity Index (PESI). METHODS: A total of 151 patients diagnosed with APE by pulmonary computed tomography angiography or ventilation/perfusion scintigraphy were included...
December 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29224807/construction-of-mass-spectra-database-and-diagnosis-algorithm-for-head-and-neck-squamous-cell-carcinoma
#2
Kei Ashizawa, Kentaro Yoshimura, Hisashi Johno, Tomohiro Inoue, Ryohei Katoh, Satoshi Funayama, Kaname Sakamoto, Sen Takeda, Keisuke Masuyama, Tomokazu Matsuoka, Hiroki Ishii
OBJECTIVES: Intraoperative identification of tumor margins is essential to achieving complete tumor resection. However, the process of intraoperative pathological diagnosis involves cumbersome procedures, such as preparation of cryosections and microscopic examination, thus requiring more than 30 min. Moreover, intraoperative diagnoses made by examining cryosections are occasionally inconsistent with postoperative diagnoses made by examining paraffin-embedded sections because the former are of poorer quality...
December 2017: Oral Oncology
https://www.readbyqxmd.com/read/29223985/external-validation-of-generic-and-cancer-specific-risk-stratification-tools-in-patients-with-pulmonary-embolism-and-active-cancer
#3
Erin R Weeda, Jonathan T Caranfa, Simon B Zeichner, Craig I Coleman, Elaine Nguyen, Christine G Kohn
Background: Numerous risk stratification tools exist to predict early post-pulmonary embolism (PE) mortality; however, few were specifically designed for use in patients with cancer. This study sought to evaluate the performance of 3 cancer-specific (RIETE, POMPE-C, and Font criteria) and 3 generic (Hestia, Pulmonary Embolism Severity Index [PESI], and Geneva prognostic score [GPS]) risk stratification tools for predicting 30-day post-PE mortality in patients with active cancer. Methods: We identified consecutive, adult, objectively confirmed patients with PE and active cancer presenting to our institution from November 2010 to January 2014...
December 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29080550/frequency-of-use-and-acceptability-of-clinical-prediction-rules-for-pulmonary-embolism-among-swiss-general-internal-medicine-residents
#4
N Faller, O Stalder, A Limacher, S Bassetti, J H Beer, D Genné, E Battegay, D Hayoz, J Leuppi, B Mueller, A Perrier, G Waeber, N Rodondi, D Aujesky
INTRODUCTION: Whether clinical prediction rules for pulmonary embolism are accepted and used among general internal medicine residents remains uncertain. We therefore evaluated the frequency of use and acceptability of the Revised Geneva Score (RGS) and the Pulmonary Embolism Severity Index (PESI), and explored which factors were associated with rule use. MATERIALS/METHODS: In an online survey among general internal medicine residents from 10 Swiss hospitals, we assessed rule acceptability using the Ottawa Acceptability of Decision Rules Instrument (OADRI) and explored the association between physician and training-related factors and rule use using mixed logistic regression models...
October 18, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29037399/comparison-of-heat-strain-recovery-in-different-anti-heat-stress-clothing-ensembles-after-work-to-exhaustion
#5
Yijie Zhao, Wen Yi, Albert P C Chan, Daniel W M Chan
A hot environment combined with physically demanding tasks can subject workers to a higher risk of heat stress. A series of regulations and guidelines have been proposed to design appropriate anti-heat stress work uniform to reduce body heat strain. The present study aimed to examine heat strain recovery in different anti-heat stress clothing ensembles after work to exhaustion in the heat. 10 healthy males performed intermittent treadmill running/walking to exhaustion, followed by 30min passive recovery sitting in a climatic chamber, which simulated the hot and humid outdoor environment (34°C temperature, 60% relative humidity, 0...
October 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29032372/parenchymal-sparing-surgery-for-the-surgical-treatment-of-multiple-colorectal-liver-metastases-is-a-safer-approach-than-major-hepatectomy-not-impairing-patients-prognosis-a-bi-institutional-propensity-score-matched-analysis
#6
Matteo Donadon, Matteo Cescon, Alessandro Cucchetti, Matteo Cimino, Guido Costa, Benedetta Pesi, Giorgio Ercolani, Antonio Daniele Pinna, Guido Torzilli
BACKGROUND: The performance of parenchymal-sparing hepatectomy (PSH) versus major hepatectomy (MH) in patients with multiple colorectal liver metastases (CLM) is a matter that is yet debated. We investigated the outcome of patients with multiple CLM undergoing PSH instead of MH. METHODS: Databases at 2 institutions were reviewed. A propensity score-matched analysis was applied. Among 554 patients, 110 undergoing PSH and 110 undergoing MH were matched. They were similar in baseline characteristics, comorbidity, and tumor features...
October 14, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/28976263/physiological-and-perceptual-strain-of-firefighters-during-graded-exercise-to-exhaustion-at-40-%C3%A2-c-and-10-%C3%A2-c
#7
Erna von Heimburg, Mariann Sandsund, Tone Pedersen Rangul, Randi Eidsmo Reinertsen
PURPOSE: To study whether perceptual identification should be included as a measure to evaluate physiological stress. METHODS: Physiological variables; oxygen uptake (VO2), ventilation, heart rate (HR), blood lactate concentration, rectal temperature (Trec) and mean skin temperature (Tskin), perceptual variables; rate of perceived exertion (RPE), thermal sensation (TS) and time to exhaustion were measured at submaximal and maximal intensities during graded exercise on a treadmill to exhaustion in 12 firefighters wearing protective clothing and extra mass at 40 °C and 10 °C...
October 4, 2017: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/28817673/the-plasmid-encoded-ipf-and-klf-fimbriae-display-different-expression-and-varying-roles-in-the-virulence-of-salmonella-enterica-serovar-infantis-in-mouse-vs-avian-hosts
#8
Gili Aviv, Laura Elpers, Svetlana Mikhlin, Helit Cohen, Shaul Vitman Zilber, Guntram A Grassl, Galia Rahav, Michael Hensel, Ohad Gal-Mor
Salmonella enterica serovar Infantis is one of the prevalent Salmonella serovars worldwide. Different emergent clones of S. Infantis were shown to acquire the pESI virulence-resistance megaplasmid affecting its ecology and pathogenicity. Here, we studied two previously uncharacterized pESI-encoded chaperone-usher fimbriae, named Ipf and Klf. While Ipf homologs are rare and were found only in S. enterica subspecies diarizonae and subspecies VII, Klf is related to the known K88-Fae fimbria and klf clusters were identified in seven S...
August 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28811022/intact-metabolite-profiling-of-mouse-brain-by-probe-electrospray-ionization-triple-quadrupole-tandem-mass-spectrometry-pesi-ms-ms-and-its-potential-use-for-local-distribution-analysis-of-the-brain
#9
Yumi Hayashi, Kei Zaitsu, Tasuku Murata, Tomomi Ohara, Stéphane Moreau, Maiko Kusano, Hiroshi Tanihata, Hitoshi Tsuchihashi, Akira Ishii, Tetsuya Ishikawa
Probe electrospray ionization (PESI), which is an ambient ionization technique, enables us to analyze intact endogenous metabolites without sample preparation. In this study, we applied the newly developed method of PESI coupled to tandem mass spectrometry (PESI/MS/MS) to analyze metabolites in mouse brain, where its lipid composition often interfere with MS-based metabolome analysis. As a result, PESI/MS/MS directly detected 25 metabolites in a mouse frontal cortex, and clearly discriminated the metabolic profiles of mice model with energy metabolism disruption from control mice...
August 29, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28766495/pulmonary-embolism-with-endovascular-thrombolysis-for-thrombosed-hemodialysis-arteriovenous-access%C3%A2
#10
Yogeshwar Singh Rajaram, Thong Le, Maree Ross-Smith, Andrew Owen, Jason Chuen, Peter F Mount
AIMS: Acute thrombosis of hemodialysis (HD) arteriovenous access is an urgent problem for HD patients and is commonly managed by endovascular thrombolysis. Pulmonary embolism (PE) is a recognized complication of HD access thrombosis and thrombolysis but the risk and outcomes are unclear. This study aims to determine the incidence, predictors, and outcomes of PE after endovascular thrombolysis of HD arteriovenous access in patients presenting with acute thrombosis. MATERIALS AND METHODS: A single-center retrospective study was performed for all adult chronic kidney disease patients undergoing arteriovenous access thrombolysis between January 1, 2012, and December 31, 2014...
September 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28683900/derivation-and-validation-of-a-novel-prediction-model-to-identify-low-risk-patients-with-acute-pulmonary-embolism
#11
Muthiah Subramanian, Sowmya Gopalan, Srinivasan Ramadurai, Preetam Arthur, Mukund A Prabhu, Rajesh Thachathodiyl, Kumaraswamy Natarajan
Accurate identification of low-risk patients with acute pulmonary embolism (PE) who may be eligible for outpatient treatment or early discharge can have substantial cost-saving benefit. The purpose of this study was to derive and validate a prediction model to effectively identify patients with PE at low risk of short-term mortality, right ventricular dysfunction, and other nonfatal outcomes. This study analyzed data from 400 consecutive patients with acute PE. We derived and internally validated our prediction rule based on clinically significant variables that are routinely available at initial examination and that were categorized and weighted using coefficients in the multivariate logistic regression...
August 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28667815/pulmonary-thromboembolism-in-an-emergency-hospital-are-our-patients-different
#12
REVIEW
Ana Maria Balahura, Andrada Guţă, Vlad Mihalcea, Emma Weiss, Maria Dorobanţu, Daniela Bartoş, Elisabeta Bădilă, Gheorghe Andrei Dan
INTRODUCTION: Pulmonary thromboembolism (PTE) represents a medical emergency and is the third most common cause of mortality after myocardial infarction and stroke. The purpose of this study was to describe the characteristics and management of patients with PTE admitted in a referral emergency hospital in Romania. MATERIAL AND METHODS: We retrospectively reviewed all cases of PTE diagnosed in one of the largest emergency hospitals in Bucharest during a 2-year period (January 2014 - December 2016)...
December 1, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28666174/safety-feasibility-and-patient-reported-outcome-measures-of-outpatient-treatment-of-pulmonary-embolism
#13
Stefan Walen, Bianca Katerberg, Martijn F Boomsma, Jan Willem K van den Berg
BACKGROUND: Despite growing evidence on safe and feasible outpatient treatment for acute pulmonary embolism (PE), the majority of patients is still treated in an inpatient setting. This is probably due to a lack of clear guidelines on this subject. OBJECTIVES: To evaluate safety and patient reported outcome measures (PROM) on outpatient treatment of acute PE. METHODS: We conducted a prospective cohort study. 250 patients presenting with acute PE and Pulmonary Embolism Severity Index (PESI) class I or II were enrolled...
June 23, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28646727/pulmonary-embolism-prognostic-factors-and-length-of-hospital-stay-a-cohort-study
#14
Marco Paolo Donadini, Francesco Dentali, Marco Castellaneta, Paola Gnerre, Micaela La Regina, Luca Masotti, Filippo Pieralli, Fulvio Pomero, Roberta Re, Luigina Guasti, Walter Ageno, Alessandro Squizzato
INTRODUCTION: Patients with pulmonary embolism (PE) are commonly admitted to hospital for their initial treatment. We aimed to assess the association of length of hospital stay with commonly available clinical variables and their combinations. METHODS: A retrospective multicenter cohort study was conducted on consecutive PE patients admitted to eight Italian centers. Logistic regression analysis was performed to evaluate the association between the length of hospital stay and the Pulmonary Embolism Severity Index (PESI) parameters, National Early Warning Score (NEWS) and other possible determinants...
August 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28594950/association-between-computed-tomography-obstruction-index-and-mortality-in-elderly-patients-with-acute-pulmonary-embolism-a-prospective-validation-study
#15
Marie Méan, Tobias Tritschler, Andreas Limacher, Stéphane Breault, Nicolas Rodondi, Drahomir Aujesky, Salah D Qanadli
INTRODUCTION: Computed tomography pulmonary angiography (CTPA) has not only become the method of choice for diagnosing acute pulmonary embolism (PE), it also allows for risk stratification of patients with PE. To date, no study has specifically examined the predictive value of CTPA findings to assess short-term prognosis in elderly patients with acute PE who are particularly vulnerable to adverse outcomes. METHODS: We studied 291 patients aged ≥65 years with acute symptomatic PE in a prospective multicenter cohort...
2017: PloS One
https://www.readbyqxmd.com/read/28526692/understanding-the-interrelationship-between-the-synthesis-of-urea-and-gluconeogenesis-by-formulating-an-overall-balanced-equation
#16
Piero L Ipata, Rossana Pesi
It is well known that a strong metabolic interrelationship exists between ureagenesis and gluconeogenesis. In this paper, we present a detailed, overall equation, describing a possible metabolic link between ureagenesis and gluconeogenesis. We adopted a guided approach in which we strongly suggest that students, when faced with the problem of obtaining the overall equation of a metabolic pathway, carefully account for all atoms and charges of the single reactions, as well as the cellular localizations of the substrates, and the related transport systems...
June 1, 2017: Advances in Physiology Education
https://www.readbyqxmd.com/read/28525830/outpatient-management-of-pulmonary-embolism
#17
REVIEW
P-M Roy, T Moumneh, A Penaloza, O Sanchez
Despite clear potential benefits of outpatient care, most patients suffering from pulmonary embolism (PE) are currently hospitalized due to the fear of possible adverse events. Nevertheless, some teams have increased or envisage to increase outpatient treatment or early discharge. We performed a narrative systematic review of studies published on this topic. We identified three meta-analyses and 23 studies, which involved 3671 patients managed at home (n=3036) or discharged early (n=535). Two main different approaches were applied to select patients eligible for outpatient in recent prospective studies, one based on a list of pragmatic criteria as the HESTIA rule, the other adding severity criteria (i...
May 4, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28483962/comparative-analysis-of-extended-spectrum-%C3%AE-lactamase-ctx-m-65-producing-salmonella-enterica-serovar-infantis-isolates-from-humans-food-animals-and-retail-chickens-in-the-united-states
#18
Heather Tate, Jason P Folster, Chih-Hao Hsu, Jessica Chen, Maria Hoffmann, Cong Li, Cesar Morales, Gregory H Tyson, Sampa Mukherjee, Allison C Brown, Alice Green, Wanda Wilson, Uday Dessai, Jason Abbott, Lavin Joseph, Jovita Haro, Sherry Ayers, Patrick F McDermott, Shaohua Zhao
We sequenced the genomes of 10 Salmonella enterica serovar Infantis isolates containing blaCTX-M-65 obtained from chicken, cattle, and human sources collected between 2012 and 2015 in the United States through routine National Antimicrobial Resistance Monitoring System (NARMS) surveillance and product sampling programs. We also completely assembled the plasmids from four of the isolates. All isolates had a D87Y mutation in the gyrA gene and harbored between 7 and 10 resistance genes [aph(4)-Ia, aac(3)-IVa, aph(3')-Ic, blaCTX-M-65, fosA3, floR, dfrA14, sul1, tetA, aadA1] located in two distinct sites of a megaplasmid (∼316 to 323 kb) similar to that described in a blaCTX-M-65-positive S Infantis isolate from a patient in Italy...
July 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28472317/surgical-embolectomy-for-high-risk-acute-pulmonary-embolism-is-standard-therapy
#19
Daisuke Shiomi, Hiroshi Kiyama, Masatsugu Shimizu, Muneaki Yamada, Naohiro Shimada, Aya Takahashi, Nobuaki Kaki
OBJECTIVES: Acute massive pulmonary embolism (AMPE) is a life-threatening condition that often induces rapid haemodynamic deterioration. The mortality of surgical embolectomy is still poor in patients with preoperative cardiopulmonary arrest (CPA). We analysed the outcome of surgical pulmonary embolectomy for haemodynamically unstable patients. METHODS: Thirty-one patients underwent surgical embolectomy for haemodynamically unstable AMPE. The indications for surgical embolectomy were (i) <7 days from onset, (ii) haemodynamically unstable, (iii) massive clots in bilateral pulmonary arteries or unilateral pulmonary artery occlusion with a floating clot in the main pulmonary artery or right atrium and (iv) right ventricular dilatation in transthoracic echocardiography...
August 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28337398/desorption-in-mass-spectrometry
#20
Dilshadbek Tursunbayevich Usmanov, Satoshi Ninomiya, Lee Chuin Chen, Subhrakanti Saha, Mridul Kanti Mandal, Yuji Sakai, Rio Takaishi, Ahsan Habib, Kenzo Hiraoka, Kentaro Yoshimura, Sen Takeda, Hiroshi Wada, Hiroshi Nonami
In mass spectrometry, analytes must be released in the gas phase. There are two representative methods for the gasification of the condensed samples, i.e., ablation and desorption. While ablation is based on the explosion induced by the energy accumulated in the condensed matrix, desorption is a single molecular process taking place on the surface. In this paper, desorption methods for mass spectrometry developed in our laboratory: flash heating/rapid cooling, Leidenfrost phenomenon-assisted thermal desorption (LPTD), solid/solid friction, liquid/solid friction, electrospray droplet impact (EDI) ionization/desorption, and probe electrospray ionization (PESI), will be described...
2017: Mass Spectrometry
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