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https://www.readbyqxmd.com/read/28635354/the-effects-of-food-on-opioid-induced-nausea-and-vomiting-and-pharmacological-parameters-a-systematic-review
#1
Robert B Raffa, Robert Colucci, Joseph V Pergolizzi
Opioids remain the standard of care for treating moderate to severe pain resulting from surgery or injury in cases of acute pain, and are recommended for patients who have not responded to nonopioid analgesics. Effective management of pain has an impact on clinical course and often depends on achieving an acceptable balance between opioid efficacy, safety, and tolerability. Common opioid-related adverse events such as nausea and vomiting are associated with an overall lower achievement of effective pain management and patient satisfaction...
June 21, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28609421/abuse-deterrent-opioids
#2
(no author information available yet)
No abstract text is available yet for this article.
June 5, 2017: Medical Letter on Drugs and Therapeutics
https://www.readbyqxmd.com/read/28602044/the-dynamic-interaction-between-pain-and-opioid-misuse
#3
REVIEW
Adrianne R Wilson-Poe, Jose A Moron
In 2014, drug overdose surpassed automobile accidents as the number one cause of accidental death for the first time in US history. The overdose epidemic is largely driven by opioids, and genuine prescription opioid analgesics play the biggest role in this phenomenon. Despite advancements in abuse deterrent formulations, prescription drug monitoring programs, and clinical assessments for the detection of abuse potential, drug overdoses continue to escalate. The CDC has recently issued new guidelines for opioid prescription, yet even these recommendations have their shortcomings...
June 11, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28570346/child-welfare-professionals-determination-of-when-children-s-access-or-potential-access-to-loaded-firearms-constitutes-child-neglect
#4
Erin M Evans, Charles A Jennissen, Resmiye Oral, Gerene M Denning
BACKGROUND: Pediatric deaths and injuries from access to firearms are a significant public health problem. No studies have examined how experts determine child neglect regarding firearm access in the home. Our study objectives were to identify factors that influenced pediatric experts' finding of firearm-related child neglect and to assess their attitudes toward child access prevention (CAP) laws. METHODS: A survey was distributed to American Academy of Pediatrics Section on Child Abuse and Neglect members...
May 30, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28567699/effects-of-nalfurafine-on-the-reinforcing-thermal-antinociceptive-and-respiratory-depressant-effects-of-oxycodone-modeling-an-abuse-deterrent-opioid-analgesic-in-rats
#5
E Andrew Townsend, Jennifer E Naylor, S Stevens Negus, Shelley R Edwards, Hina N Qureshi, Hunter W McLendon, Christopher R McCurdy, Coco N Kapanda, Jussara M do Carmo, Fernanda S da Silva, John E Hall, Kenneth J Sufka, Kevin B Freeman
RATIONALE: Strategies to reduce the misuse of mu opioid agonists are critically needed. Previous work has shown that kappa opioid agonists can diminish the abuse-related effects and augment the antinociceptive effects of mu agonists. However, use of traditional kappa agonists is limited by their dysphoric side effects. OBJECTIVES: The current study examined the effects of nalfurafine, a clinically available atypical kappa agonist, on the reinforcing, thermal antinociceptive, and respiratory-depressant effects of oxycodone in male rats...
May 31, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28564568/abuse-deterrent-opioid-formulations-putting-the-potential-benefits-into-perspective
#6
William C Becker, David A Fiellin
Death rates among middle-aged adults, the largest demographic group in the United States, are on the rise for the first time in several decades. This trend can largely be explained by an increase in drug-overdose deaths, the majority of which involve opioids. The opioid crisis has attracted..
June 1, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28511685/respectful-maternity-care-in-ethiopian-public-health-facilities
#7
Ephrem D Sheferaw, Eva Bazant, Hannah Gibson, Hone B Fenta, Firew Ayalew, Tsigereda B Belay, Maria M Worku, Aelaf E Kebebu, Sintayehu A Woldie, Young-Mi Kim, T van den Akker, Jelle Stekelenburg
BACKGROUND: Disrespect and abuse of women during institutional childbirth services is one of the deterrents to utilization of maternity care services in Ethiopia and other low- and middle-income countries. This paper describes the prevalence of respectful maternity care (RMC) and mistreatment of women in hospitals and health centers, and identifies factors associated with occurrence of RMC and mistreatment of women during institutional labor and childbirth services. METHODS: This study had a cross sectional study design...
May 16, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28448223/the-alerrt-%C3%A2-instrument-a-quantitative-measure-of-the-effort-required-to-compromise-prescription-opioid-abuse-deterrent-tablets
#8
Edward J Cone, August R Buchhalter, Karsten Lindhardt, Torben Elhauge, Jeffrey M Dayno
BACKGROUND: US FDA guidance recommends measuring the degree of effort needed to manipulate abuse-deterrent (AD) opioids. The ALERRT(®) instrument (PinneyAssociates; Bethesda, MD) uses visual analog scales to assess the labor, effort, and resources necessary to physically compromise AD product candidates in standardized settings. OBJECTIVE: Use the ALERRT(®) instrument for testing morphine abuse-deterrent, extended-release, injection-molded tablets (ADER-IMT) 60 and 100 mg and the comparators immediate-release (IR) morphine sulfate 30 mg and extended-release (ER) morphine sulfate 60 mg...
May 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28419074/arymo-er-a-new-abuse-deterrent-morphine-formulation
#9
(no author information available yet)
No abstract text is available yet for this article.
April 24, 2017: Medical Letter on Drugs and Therapeutics
https://www.readbyqxmd.com/read/28414990/medical-outcomes-associated-with-prescription-opioid-abuse-via-oral-and-non-oral-routes-of-administration
#10
Jody L Green, Becki Bucher Bartelson, M Claire Le Lait, Carl L Roland, Elizabeth T Masters, Jack Mardekian, J Elise Bailey, Richard C Dart
BACKGROUND: Prescription opioid abuse and misuse is a serious and growing public health issue. While the most common form of abuse is swallowing intact tablets/capsules, some abusers manipulate, or tamper with, these medications by altering the dosage form to allow for non-oral routes of administration (e.g., injection, inhalation) in order to achieve more rapid or enhanced psychoactive effects. Because administration of opioids via non-oral routes results in greater systemic availability and more rapid central nervous system penetration, we hypothesized that death and major medical outcomes occur more frequently with non-oral routes compared to oral route alone...
March 28, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28381914/pharmaceutical-approval-update
#11
Mary Choy
Abuse-deterrent hydrocodone bitartrate (Vantrela ER) for long-term opioid treatment; etelcalcetide (Parsabiv) for secondary hyperparathyroidism in patients with chronic kidney disease on hemodialysis; and deflazacort (Emflaza) for Duchenne muscular dystrophy.
April 2017: P & T: a Peer-reviewed Journal for Formulary Management
https://www.readbyqxmd.com/read/28351350/manifestations-and-drivers-of-mistreatment-of-women-during-childbirth-in-kenya-implications-for-measurement-and-developing-interventions
#12
Charlotte E Warren, Rebecca Njue, Charity Ndwiga, Timothy Abuya
BACKGROUND: Disrespect and abuse or mistreatment of women by health care providers in maternity settings has been identified as a key deterrent to women seeking delivery care. Mistreatment includes physical and verbal abuse, stigma and discrimination, a poor relationship between women and providers and policy and health systems challenges. This paper uses qualitative data to describe mistreatment of women in Kenya. METHODS: Data are drawn from implementation research conducted in 13 facilities and communities...
March 28, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28333577/abuse-deterrent-opioid-formulations-329
#13
Ryann O'Neill, Kimberly Lor, Jennifer Pruskowski
No abstract text is available yet for this article.
June 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28318019/corrigendum-the-effect-of-an-abuse-deterrent-opioid-formulation-oxycontin-on-opioid-abuse-related-outcomes-in-the-postmarketing-setting
#14
(no author information available yet)
No abstract text is available yet for this article.
April 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28277802/oxycodone-extended-release-capsules-for-the-treatment-of-chronic-pain
#15
Sebastiano Mercadante
As a consequence of greater prescription opioid utilization, there has been the parallel increase in misuse, abuse, and overdose, which are serious risks. Associated new formulations may be safer. Areas covered: The introduction of abuse-deterrent opioid formulations and continuous programs to improve opioid prescribing practices may limit the opioid abuse and its consequences. Oxycodone extended release capsules are an extended-release (ER), microsphere-in-capsule abuse-deterrent-formulation designed to retain its extended-release properties following tampering or misuse (e...
March 10, 2017: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/28251526/management-of-patients-on-abuse-deterrent-opioids-in-the-ambulatory-surgery-setting
#16
REVIEW
Nalini Vadivelu, Daniel Chang, Leandro Lumermann, Thomas Suchy, Matthew M Burg, Manuel L Fontes
PURPOSE OF REVIEW: The use of prescription opioids for acute and chronic pain has become more prevalent than ever, and concurrent with the increased prescribing of opioids, there has been a steady increase in opioid abuse. Abuse is commonly associated with physical or chemical manipulation of the original opiate to provide more rapid onset of the active ingredient. RECENT FINDINGS: This growing national public health concern has led to the development of various abuse-deterring opioids with the intent of decreasing the diversion of opioids from their prescribed use...
February 2017: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/28243142/secular-trends-in-opioid-prescribing-in-the-usa
#17
Edmund J Pezalla, David Rosen, Jennifer G Erensen, J David Haddox, Tracy J Mayne
Opioid abuse and misuse in the USA is a public health crisis. The use of prescription opioid analgesics increased substantially from 2002 through 2010, then plateaued and began to decrease in 2011. This study examined prescriptions of branded and generic immediate- and extended-release opioid analgesics from 1992 to 2016. This was juxtaposed against state and federal policies designed to decrease overutilization and abuse, as well as the launch of new opioid products, including opioids with abuse-deterrent properties (OADPs)...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28162702/-457-effectiveness-of-hysingla-%C3%A2-er-a-once-daily-single-entity-hydrocodone-with-abuse-deterrent-properties-in-treating-chronic-nonmalignant-and-nonneuropathic-pain-in-patients-with-depression-and-anxiety
#18
S Lynch, L Taber, E He, R Shah
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28162693/-442-pharmacodynamic-data-assessing-the-abuse-potential-of-a-novel-abuse-deterrent-oxycodone-formulation-eli-200-compared-to-oxycodone-immediate-release-oral-intact-eli-200-and-placebo-in-healthy-non-dependent-recreational-opioid-users-following-intranasal
#19
B Setnik, K Schoedel, C Bartlett, C Dick, N Hakim, P Geoffroy
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28162691/-444-clinical-results-of-an-abuse-potential-study-with-remoxy-%C3%A2-an-abuse-deterrent-extended-release-product
#20
L Webster, N Friedmann
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
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