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abuse deterrent

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https://www.readbyqxmd.com/read/28162702/-457-effectiveness-of-hysingla-%C3%A2-er-a-once-daily-single-entity-hydrocodone-with-abuse-deterrent-properties-in-treating-chronic-nonmalignant-and-nonneuropathic-pain-in-patients-with-depression-and-anxiety
#1
S Lynch, L Taber, E He, R Shah
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28162693/-442-pharmacodynamic-data-assessing-the-abuse-potential-of-a-novel-abuse-deterrent-oxycodone-formulation-eli-200-compared-to-oxycodone-immediate-release-oral-intact-eli-200-and-placebo-in-healthy-non-dependent-recreational-opioid-users-following-intranasal
#2
B Setnik, K Schoedel, C Bartlett, C Dick, N Hakim, P Geoffroy
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28162691/-444-clinical-results-of-an-abuse-potential-study-with-remoxy-%C3%A2-an-abuse-deterrent-extended-release-product
#3
L Webster, N Friedmann
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28162680/-430-bioequivalence-and-food-effect-of-a-novel-abuse-deterrent-ad-extended-release-er-morphine-product-candidate-compared-with-a-currently-available-non-ad-er-morphine-product
#4
J Dayno, J Lawler, G Niebler, K Lindhardt
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28162673/-425-dissolution-studies-in-the-presence-of-alcohol-with-an%C3%A2-abuse-deterrent-extended-release-morphine-product-candidate
#5
T Elhauge, L Kristensen, J Dayno, K Lindhardt
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28162671/-422-pharmacodynamic-effects-from-a-category-3-intranasal-human-abuse-potential-study-of-an-abuse-deterrent-extended-release-morphine-product-candidate-in-nondependent-recreational-opioid-users
#6
L Webster, M Smith, J Lawler, K Lindhardt, J Dayno
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28162496/-263-a-model-to-quantify-potential-medical-events-avoided-and-cost-savings-from-abuse-deterrent-opioids
#7
A White, M Yenikomshian, M Carson, E Masters, C Roland
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28162368/-145-relative-abuse-of-abuse-deterrent-formulations-via-alternative-oral-routes
#8
S Butler, R Black, A Fleming
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27983881/hysingla%C3%A2-er-a-once-daily-single-entity-hydrocodone-with-abuse-deterrent-properties-in-treating-chronic-nonmalignant-and-nonneuropathic-pain-in-patients-with-osteoarthritis
#9
MULTICENTER STUDY
Louise Taber, Stacy Baldridge, Ellie He, Steven R Ripa
OBJECTIVES: Osteoarthritis (OA)-related chronic pain is associated with physical and psychosocial impairment as well as poorer quality of life. There is limited literature on long-term opioid therapy in OA patients. This post hoc analysis of OA patients assessed the long-term safety and effectiveness of a once-daily, single-entity, extended-release formulation of hydrocodone (HYD) with abuse-deterrent properties for the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which other treatment options are inadequate...
January 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/27960575/assessing-the-impact-of-abuse-deterrent-opioids-ados-identifying-epidemiologic-factors-related-to-new-entrants-with-low-population-exposure
#10
COMPARATIVE STUDY
Carl L Roland, Beatrice Setnik, David A Brown
OBJECTIVE: Prescription opioid misuse and abuse is a serious public health concern that can lead to overdose, addiction, and death. The development of opioid formulations designed to deter misuse and abuse is considered an important step towards addressing the problem, but the extent to which abuse-deterrent opioids (ADOs) actually deter abuse in the community requires confirmation through epidemiologic studies. Epidemiologic evaluations of misuse and abuse present several unique challenges related to study design, sources of data, and methodology, particularly for new entrant ADOs with low population exposure...
January 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/27956191/effects-of-excipients-and-curing-process-on-the-abuse-deterrent-properties-of-directly-compressed-tablets
#11
Ziyaur Rahman, Ahmed S Zidan, Maxwell Korang-Yeboah, Yang Yang, Akhtar Siddiqui, Diaa Shakleya, Mansoor A Khan, Celia Cruz, Muhammad Ashraf
The objective of the present investigation was to understand the effects of excipients and curing process on the abuse deterrent properties (ADP) of Polyox™ based directly compressible abuse deterrent tablet formulations (ADFs). The excipients investigated were lactose (monohydrate or anhydrous), microcrystalline cellulose and hydroxypropyl methylcellulose. The ADPs studied were tablet crush resistance or hardness, particle size distribution following mechanical manipulation, drug extraction in water and alcohol, syringeability and injectability...
December 9, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27915497/current-and-future-development-of-extended-release-abuse-deterrent-opioid-formulations-in-the-united-states
#12
REVIEW
Lynn R Webster, John Markman, Edward J Cone, Gwendolyn Niebler
Prescription opioid misuse and abuse in the United States (US) is epidemic and is a major burden on health-care resources and costs to society. The need to significantly reduce the risks of prescription opioid misuse and abuse must be balanced with the important needs of patients with chronic pain who may benefit from treatment with opioids. The use of abuse-deterrent formulations (ADFs) of prescription opioids is one approach that could reduce the risk of prescription opioid abuse and misuse while maintaining access to opioids...
January 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/27897471/use-of-risk-mitigation-practices-by-family-nurse-practitioners-prescribing-opioids-for-the-management-of-chronic-nonmalignant-pain
#13
Sahil Chaudhary, Peggy Compton
BACKGROUND: Ongoing opioid analgesic use in patients suffering from chronic nonmalignant pain (CNMP) has been associated with the development of opioid misuse, abuse, addiction, and overdose. To prevent these adverse outcomes, it is important that family nurse practitioners (FNPs) implement recommended risk mitigation practices (RMPs) when treating CNMP patients with opioids. METHODS: A national sample of 856 FNPs was invited to answer an online survey about their utilization of opioids and RMPs in treating CNMP...
January 2017: Substance Abuse
https://www.readbyqxmd.com/read/27873179/oxycodone-deterx-%C3%A2-a-novel-abuse-deterrent-extended-release-analgesic-option-for-the-treatment-of-patients-with-chronic-pain
#14
REVIEW
Jeff Gudin
BACKGROUND: Extended-release (ER) opioid analgesics are commonly used to provide safe and effective pain relief to treat pain severe enough to require around-the-clock, long-term dosing. These ER opioid formulations usually contain more drug per dosage unit than immediate-release (IR) agents, and therefore bring with them challenges related to both opioid abuse and misuse, often through manipulation of the dosage form. Oxycodone DETERx(®) (Xtampza(®) ER, Collegium Pharmaceutical, Inc...
December 2016: Pain and Therapy
https://www.readbyqxmd.com/read/27832472/oxycodone-deterx-%C3%A2-er-capsules-a-review-in-severe-chronic-pain
#15
Yvette N Lamb, Karly P Garnock-Jones, Susan J Keam
Oxycodone DETERx (®) extended-release (ER) capsules (Xtampza(®) ER), an abuse-deterrent formulation of oxycodone as the myristate salt, are approved in the USA for the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate. This narrative review discusses the clinical efficacy and tolerability of the oxycodone DETERx (®) ER capsule formulation in the management of severe pain, and provides an overview of pharmacokinetics, abuse-deterrent properties and alternative administration options...
December 2016: Drugs
https://www.readbyqxmd.com/read/27718163/hydrocodone-bitartrate-er-hysingla-%C3%A2-er-a-review-in-chronic-pain
#16
REVIEW
Sohita Dhillon
Hydrocodone bitartrate extended-release (Hysingla(®) ER; referred to hereafter as hydrocodone ER) was the first single-entity hydrocodone formulation recognized by the US FDA as having abuse-deterrent properties. It is indicated for the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate. Once-daily oral hydrocodone ER provides consistent plasma hydrocodone concentrations and sustained analgesia over the 24-h dosing interval...
November 2016: Clinical Drug Investigation
https://www.readbyqxmd.com/read/27716575/sustained-reduction-of-diversion-and-abuse-after-introduction-of-an-abuse-deterrent-formulation-of-extended-release-oxycodone
#17
Stevan Geoffrey Severtson, Matthew S Ellis, Steven P Kurtz, Andrew Rosenblum, Theodore J Cicero, Mark W Parrino, Michael K Gilbert, Mance E Buttram, Nabarun Dasgupta, Becki BucherBartelson, Jody L Green, Richard C Dart
BACKGROUND: The development of abuse deterrent formulations is one strategy for reducing prescription opioid misuse and abuse. A putative abuse deterrent formulation of oxycodone extended release (OxyContin(®)) was introduced in 2010. Early reports demonstrated reduced abuse and diversion, however, an analysis of social media found 32 feasible methods to circumvent the abuse deterrent mechanism. We measured trends of diversion, abuse and street price of OxyContin to assess the durability of the initial reduction in abuse...
November 1, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27673203/poster-457-bioequivalence-and-food-effect-of-a-novel-abuse-deterrent-ad-extended-release-er-morphine-product-candidate-compared-with-a-currently-available-non-ad-er-morphine-product
#18
Jeffrey M Dayno, John Lawler, Gwendolyn Niebler, Karsten Lindhardt
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27673177/poster-427-pharmacodynamic-effects-from-a-category-3-intranasal-human-abuse-potential-study-of-an-abuse-deterrent-extended-release-morphine-product-candidate-in-nondependent-recreational-opioid-users
#19
Lynn R Webster, Michael D Smith, John Lawler, Karsten Lindhardt, Jeffrey M Dayno
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27673172/poster-420-pharmacodynamic-effects-from-a-category-3-oral-human-abuse-potential-study-of-an-abuse-deterrent-extended-release-morphine-product-candidate-in-nondependent-recreational-opioid-users
#20
Michael D Smith, Lynn R Webster, John Lawler, Karsten Lindhardt, Jeffrey M Dayno
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
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