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https://www.readbyqxmd.com/read/29703031/use-of-low-level-laser-therapy-on-children-aged-1-to-5-years-with-energy-protein-malnutrition-a-clinical-trial
#1
Karlla Almeida Vieira, Clarissa Moraes Bastos, Marilya Gabriella Correia Vitor, Alessandro Melo Deana, Kristianne Porta Santos Fernandes, Maria Fernanda Setúbal Destro Rodrigues, Vanessa Christina Santos Pavesi, Sandra Kalil Bussadori
BACKGROUND: Episodes of malnutrition in early childhood can produces alterations in the salivary glands. The investigation of mechanisms that can reduce the impact of malnutrition on the defenses of the organism is of the utmost important and interest to public health. The aim of this study is to evaluate the effect of low-level laser on the saliva of children aged 1 to 5 years with energy-protein malnutrition. METHODS: Mandatory inclusion criteria are diagnosis of malnutrition...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29670723/plunging-ranula-in-a-78-year-old-male-a-rare-case-report
#2
Arunkumar Kamalakaran, Balaji Jayaraman, Saravanan Balasubramaniam, Rohini Thirunavukkarasu, Bharathi Ramakrishnan
The term Ranula is a Latin word meaning frog. It refers to a bluish translucent cystic lesion in the floor of the mouth resembling the underbelly of a frog. Ranulas can be true cysts occurring due to ductal obstruction of the sublingual gland or a minor salivary gland or a pseudocyst as a result of ductal injury leading to extravasation and accumulation of saliva in the surrounding tissues. Clinically ranulas present as intraoral or plunging ranulas. The prevalence of ranula is 0.2% per 1000 patients Ranulas account for 6% of all salivary gland cysts...
January 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29656342/prosaposin-and-its-receptors-are-differentially-expressed-in-the-salivary-glands-of-male-and-female-rats
#3
Farzana Islam, Md Sakirul Islam Khan, Hiroaki Nabeka, Shouichiro Saito, Xuan Li, Tetsuya Shimokawa, Kimiko Yamamiya, Naoto Kobayashi, Seiji Matsuda
Salivary glands produce various neurotrophins that are thought to regulate salivary function during normal and pathological conditions. Prosaposin (PSAP) is a potent neurotrophin found in several tissues and various biological fluids and may play roles in the regulation of salivary function. However, little is known about PSAP in salivary glands. As the functions of salivary glands are diverse based on age and sex, this study examines whether PSAP and its receptors, G protein-coupled receptor 37 (GPR37) and GPR37L1, are expressed in the salivary glands of rats and whether sex and aging affect their expression...
April 14, 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29649019/nut-carcinoma-of-the-salivary-glands-clinicopathologic-and-molecular-analysis-of-3-cases-and-a-survey-of-nut-expression-in-salivary-gland-carcinomas
#4
Abbas Agaimy, Isabel Fonseca, Carmo Martins, Khin Thway, Ryan Barrette, Kevin J Harrington, Arndt Hartmann, Christopher A French, Cyril Fisher
NUT carcinoma (NC) represents a rare subset of highly aggressive poorly differentiated carcinomas characterized by rearrangement of the NUT (aka NUTM1, nuclear protein in testis) gene, most commonly fused to BRD4. Originally described as a mediastinal/thymic malignancy, NC has been reported at a variety of anatomic regions including the upper and lower aerodigestive tract. To date, only 7 NC cases of probable salivary gland origin have been reported. We herein describe 3 new cases (all affecting the parotid gland) in 2 women (39- and 55-y old) and 1 man (35-y old)...
April 11, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29622116/imaging-of-submandibular-and-sublingual-salivary-glands
#5
REVIEW
Amit K Agarwal, Sangam G Kanekar
The submandibular and sublingual salivary glands are major salivary glands with a wide spectrum of pathologic conditions. The corresponding spaces along the floor of mouth have complex anatomy, best evaluated with cross-sectional imaging. The spectrum of diseases in these regions varies from simple infection to advanced malignancy, not just from the gland itself but also from the surrounding structures. The most common abnormalities in these spaces are inflammatory and infectious, and computed tomography is currently the most common imaging modality used...
May 2018: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/29618884/simultaneous-occurrence-of-a-midline-sublingual-dermoid-cyst-with-respiratory-epithelium-and-submental-dermoid-cyst-in-a-paediatric-patient-a-case-report-and-review-of-literature
#6
Manikandhan Ramanathan, Sivapathasundharam Balasundharam, Amelia Christabel, Preethi Murali, Sneha Pandem
Aim: To present the case of a simultaneously occuring sublingual dermoid cyst with respiratory epthelium and a submental dermoid cyst, and also to review literatures on the same. Methods: A complete examination, radiograph, MRI and excision biopsy of both lesions were carried out and diagnosis was arrived at histopathologically. Results: The histopathology of the submental swelling revealed orthokeratinized stratified squamous epithelium with underlying connective tissue consisting of dense irregularly arranged collagen fibres with fibroblasts along with chronic inflammatory cell infiltrate of lymphocytes and plasma cells...
June 2018: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/29530983/the-apical-anion-exchanger-slc26a6-promotes-oxalate-secretion-by-murine-submandibular-gland-acinar-cells
#7
Taro Mukaibo, Takashi Munemasa, Alvin T George, Duy T Tran, Xin Gao, Jesse Herche, Chihiro Masaki, Gary E Shull, Manoocher Soleimani, James E Melvin
The solute carrier family 26 (SLC26) gene family encodes at least 10 different anion exchangers. SLC26 member 6 (SLC26A6 or CFEX/PAT-1) and cystic fibrosis transmembrane conductance regulator (CFTR) co-localize to the apical membrane of pancreatic duct cells where they act in concert to drive HCO3- and fluid secretion. By contrast, in the small intestine, SLC26A6 serves as the major pathway for oxalate secretion. However, little is known about the function of Slc26a6 in murine salivary glands. Here, RNA-Seq-based transcriptional profiling and Western blots revealed that Slc26a6 is highly expressed in mouse submandibular and sublingual salivary glands...
March 12, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29524350/changes-in-pge2-signaling-after-submandibulectomy-alter-post-tooth-extraction-socket-healing
#8
Claudia Ester Mohn, Gastón Rodolfo Troncoso, Clarisa Bozzini, María Inés Conti, Javier Fernandez Solari, Juan Carlos Elverdin
Saliva is very important to oral health, and a salivary deficit has been shown to bring serious problems to oral health. There is scant information about the mechanisms through which salivary glands participate in post-tooth extraction socket healing. Therefore, the aim of the present study was to investigate the effect of submandibulectomy (SMx), consisting of the ablation of submandibular and sublingual glands (SMG and SLG, respectively), on PGE2 signaling and other bone regulatory molecules, such as OPG and RANKL, involved in tooth extraction socket healing...
March 10, 2018: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29523427/physiologic-distribution-of-psma-ligand-in-salivary-glands-and-seromucous-glands-of-the-head-and-neck-on-pet-ct
#9
Thomas J W Klein Nulent, Matthijs H Valstar, Bart de Keizer, Stefan M Willems, Laura A Smit, Abrahim Al-Mamgani, Ludwig E Smeele, Robert J J van Es, Remco de Bree, Wouter V Vogel
OBJECTIVES: Prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) is used for detection and (re)staging of prostate cancer. However, healthy salivary, seromucous, and lacrimal glands also have high PSMA-ligand uptake. This study aimed to describe physiologic PSMA-ligand uptake distribution characteristics in the head and neck to aid in PSMA PET/CT interpretation and to identify possible new clinical applications for PSMA-ligand imaging. STUDY DESIGN: Thirty consecutive patients who underwent PSMA PET/CT for prostate cancer were evaluated...
May 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29424090/the-host-defense-peptide-ll-37-is-detected-in-human-parotid-and-submandibular-sublingual-saliva-and-expressed-in-glandular-neutrophils
#10
Daniel Svensson, Alexandra Aidoukovitch, Emma Anders, Birgitta Agerberth, Fredrik Andersson, Eva Ekblad, Dan Ericson, Daniel Nebel, Ulrikke Voss, Bengt-Olof Nilsson
The human host defense peptide, LL-37, is an important player in the first line of defense against invading microorganisms. LL-37 and its precursor, hCAP18, have been detected in unstimulated whole saliva but no reports showing hCAP18/LL-37 in isolated, parotid, and/or submandibular/sublingual saliva have been presented. Here, we measured the levels of hCAP18/LL-37 in human parotid and submandibular/sublingual saliva and investigated the expression of hCAP18/LL-37 in parotid and submandibular gland tissue. Parotid and submandibular/sublingual saliva was collected from healthy volunteers, and the levels of hCAP18/LL-37 in saliva were analyzed by dot blot, ELISA, and western blotting...
April 2018: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/29407168/rlj-rgd3-a-novel-recombinant-toxin-protein-from-lampetra-japonica-prevents-coronary-thrombosis-induced-acute-myocardial-infarction-by-inhibiting-platelet-functions-in-rats
#11
Shengnan Wang, Junshu Jiang, Yue Wang, Qilan Jia, Shufang Dai, Yuping Wang, Li Lv, Jihong Wang
Recombinant Lampetra japonica RGD-peptide (rLj-RGD3), a soluble protein containing three RGD sequences, was acquired from the oral salivary glands of Lampetra japonica using recombinant DNA technology. The aim of this study was to investigate the protective effects of rLj-RGD3 against acute myocardial infarction (AMI) induced by coronary artery thrombosis, as well as the underlying mechanisms. A rat model of AMI caused by ferric chloride-induced thrombosis on the surface of the left anterior descending (LAD) coronary artery was successfully established...
March 25, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29392619/hybrid-techniques-and-patients-safety-in-implementing-transoral-sublingual-thyroidectomy
#12
Kai Witzel, Tahar Benhidjeb, Cornelia Kaminski, Franz G Messenbaeck, Michael Weitzendorfer
PURPOSE: Cosmetic advantages and minimally invasive aspects become more and more important for patients undergoing thyroidectomy. We report on our personal experience and conceptual design in dealing with approaches to the thyroid gland, which we were the first to describe. We report on ideas and experiences concerning its implementation. METHODS: Our own experiences and considerations in the process of finding an endoscopic minimally invasive access in thyroidectomy are compared in a systematic review with the available literature on minimally invasive or endoscopic thyroid surgery...
April 2018: Endocrine
https://www.readbyqxmd.com/read/29382364/treatment-of-immunoglobulin-g4-related-sialadenitis-outcomes-of-glucocorticoid-therapy-combined-with-steroid-sparing-agents
#13
Xia Hong, Yan-Yan Zhang, Wei Li, Yan-Ying Liu, Zhen Wang, Yan Chen, Yan Gao, Zhi-Peng Sun, Xin Peng, Jia-Zeng Su, Zhi-Gang Cai, Lei Zhang, Jing He, Li-Min Ren, Hong-Yu Yang, Zhan-Guo Li, Guang-Yan Yu
BACKGROUND: Immunoglobulin G4-related sialadenitis (IgG4-RS) is a newly recognized immune-mediated systemic disease. Despite its good response to steroid therapy, its treatment protocol is not standardized and the long-term outcome is controversial. The study was conducted to determine the short-term and long-term outcomes of IgG4-RS patients treated with glucocorticoids and steroid-sparing immunosuppressive agents, to analyze secretory function, serological and radiological changes in salivary glands and to assess the usefulness of serum IgG4 level as an indicator of disease activity...
January 30, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29373073/transcriptional-profiling-reveals-gland-specific-differential-expression-in-the-three-major-salivary-glands-of-the-adult-mouse
#14
Xin Gao, Maria S Oei, Catherine E Ovitt, Murat Sincan, James E Melvin
RNA-Seq was used to better understand the molecular nature of the biological differences among the three major exocrine salivary glands in mammals. Transcriptional profiling found that the adult murine parotid, submandibular, and sublingual salivary glands express greater than 14,300 protein-coding genes, and nearly 2,000 of these genes were differentially expressed. Principle component analysis of the differentially expressed genes revealed three distinct clusters according to gland type. The three salivary gland transcriptomes were dominated by a relatively few number of highly expressed genes (6...
April 1, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/29338892/treatment-of-intraoral-ranulas-with-a-two-incision-fistula-technique-the-management-of-recurrence
#15
Qingtong Zhao, Mengyu Li, Renfa Lai, Shaoyi Wang
The two-incision fistula technique for the treatment of oral ranulas has recently been introduced to clinical practice. We reviewed 52 patients who had recurrences after this treatment, and explored the possible causes and underlying mechanisms. A total of 13/53 ranulas had recurred, so we repeated the operation, and one patient had the ranula and the sublingual gland resected. We found that the thin mucous membrane cracked at the double incisions, which led to the formation of a fistula and promoted the drainage of cystic fluid...
February 2018: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29332268/methylmercury-intoxication-promotes-metallothionein-response-and-cell-damage-in-salivary-glands-of-rats
#16
Leidiane Alencar de Oliveira Lima, Leonardo Oliveira Bittencourt, Bruna Puty, Rafael Monteiro Fernandes, Priscila Cunha Nascimento, Marcia Cristina Freitas Silva, Sérgio Melo Alves-Junior, João de Jesus Viana Pinheiro, Rafael Rodrigues Lima
Environmental and occupational mercury exposure is considered a major public health issue. Despite being well known that MeHg exposure causes adverse effects in several physiologic functions, MeHg effects on salivary glands still not completely elucidated. Here, we investigated the cellular MeHg-induced damage in the three major salivary glands (parotid, submandibular, and sublingual) of adult rats after chronic, systemic and low doses of MeHg exposure. Rats were exposed by 0.04 mg/kg/day over 60 days. After that, animals were euthanized and all three glands were collected...
January 14, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29283518/digestive-and-nondigestive-functions-of-rodents-salivary-glands
#17
REVIEW
V V Ivanova, I V Milto, I V Sukhodolo, O N Serebryakova, A V Buzenkova
Major salivary glands play a role not only in digestion, but also in regulation of other functions in rodents. In this review, we analyzed and summarized the data about the rodents' parotid, submandibular and sublingual salivary glands functions, which is not limited to the production of saliva and action of its hydrolytic enzymes on food in the oral cavity. In recent decades significantly expanded understanding of major salivary glands nondigestive functions. They are involved in excretion of metabolic products, maintaining fluid and electrolyte balance...
January 2017: Uspekhi Fiziologicheskikh Nauk
https://www.readbyqxmd.com/read/29219039/morphogenesis-and-mucus-production-of-epithelial-tissues-of-three-major-salivary-glands-of-embryonic-mouse-in-3d-culture
#18
Azusa Nakao, Takumi Inaba, Akiko Murakami-Sekimata, Hiroyuki Nogawa
Embryonic mouse submandibular epithelia initiate branching morphogenesis within two days when embedded in Matrigel and stimulated by members of the epidermal growth factor family. However, it is unknown whether the end buds further branch over longer culture periods, and whether saliva-producing cells differentiate there. In the present study, we cultivated three major (submandibular, sublingual and parotid) salivary epithelia from 13-day embryos for 14 days in mesenchyme-free cultures. All epithelia continued to grow and branch to form numerous acinus-like structures in medium supplemented with neuregulin 1, fibroblast growth factor 1, and insulintransferrin-sodium selenite...
December 2017: Zoological Science
https://www.readbyqxmd.com/read/29197149/cd29-is-highly-expressed-on-epithelial-myoepithelial-and-mesenchymal-stromal-cells-of-human-salivary-glands
#19
Padma Priya Togarrati, Nuntana Dinglasan, Shivani Desai, William R Ryan, Marcus O Muench
OBJECTIVE: The phenotype of the cells present in the ductal region of salivary glands have been well characterized. However, it is imperative to identify novel biomarkers that can identify different cell types present in other glandular components for the development of therapeutic strategies and diagnostics of salivary gland disorders and malignancies. Our study aimed at the characterization of the expression and distribution of various cell surface markers, especially with a focus on CD29 in human fetal as well as adult glands...
December 2, 2017: Oral Diseases
https://www.readbyqxmd.com/read/29183011/transoral-robotic-surgery-with-sialendoscopy-for-a-plunging-ranula
#20
Ryan M Carey, Benjamin L Hodnett, Christopher H Rassekh, Gregory S Weinstein
BACKGROUND/AIMS: Plunging ranulas are oral mucoceles that often cannot be visualized directly and thus can be challenging to diagnose and differentiate from other neck lesions. Surgery is the preferred treatment option, but the optimal approach requires careful consideration. METHODS: We report the case of a plunging ranula presenting as an isolated neck mass in a 33-year-old patient. This patient was treated with a novel transoral robotic surgery (TORS)-assisted approach aided by sialendoscopy...
November 29, 2017: ORL; Journal for Oto-rhino-laryngology and its related Specialties
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