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Sublingual gland

Satoko Iwasa, Hirotaka Ota, Kensuke Nishio, Mariko Ohtsu, Masafumi Kusunoki, Takahiro Gojoubori, Tetsuo Shirakawa, Masatake Asano
Toll-like receptors (TLR) recognize microbe-associated molecular patterns and induce the innate immune response. Among them, TLR5 recognizes the Gram-negative bacterial component flagellin. The aim of this study was to examine the expression of TLR5 in mouse salivary gland (SG). The SG was excised from 8- to 10-week-old female C57BL/6 mice. Salivary gland epithelial cells (SGECs) were purified and subjected to reverse transcription polymerase chain reaction (RT-PCR). Western blotting was performed to detect TLR5 expression at the protein level in several organs...
2016: Journal of Oral Science
Michihide Kono, Takafumi Satomi, Harutsugi Abukawa, On Hasegawa, Masato Watanabe, Daichi Chikazu
PURPOSE: A ranula is a pseudocyst caused by mucous extravasation from the sublingual gland. Recently, a sclerosing agent, OK-432 (picibanil), has been reported to be highly effective for treating lymphangioma and cervical cystic lesions. The present study assessed the effectiveness of OK-432 injection therapy for intraoral ranula to clarify whether it can be used as the primary treatment. PATIENTS AND METHODS: The present study was a retrospective clinical study of patients with intraoral ranula who received OK-432 injection therapy from 2005 to 2015...
August 24, 2016: Journal of Oral and Maxillofacial Surgery
Ikuho Kojima, Maya Sakamoto, Masahiro Iikubo, Hiroyuki Kumamoto, Azusa Muroi, Yumiko Sugawara, Shizuko Satoh-Kuriwada, Takashi Sasano
OBJECTIVE: We analyzed the diagnostic performance of the MR imaging findings of the parotid, submandibular, and sublingual glands to discriminate between patients with and without Sjögren's syndrome. METHODS: We retrospectively analyzed the correlation between the MR imaging and histopathological findings obtained from 69 patients with clinically suspected Sjögren's syndrome. We evaluated the heterogeneous signal intensity distribution on T1- and T2-weighted images, the multiple high-signal-intensity spots on MR sialograms, and the volume of the parotid, submandibular, and sublingual salivary glands...
August 31, 2016: Oral Diseases
Arya Amini, Timothy V Waxweiler, Jeffrey V Brower, Bernard L Jones, Jessica D McDermott, David Raben, Debashis Ghosh, Daniel W Bowles, Sana D Karam
Importance: Data on adjuvant concurrent chemoradiotherapy (CRT) after resection of salivary gland carcinomas (SGCs) are limited. Objective: To examine overall survival (OS) outcomes of patients who receive CRT vs radiotherapy (RT) alone after resection of SGCs. Design, Setting, and Participants: The National Cancer Data Base (NCDB), a hospital-based registry that represents 70% of all cancer cases in the United States, was queried for patients who underwent resection of major SGCs with at least 1 high-risk feature (T3-T4 stage, N1-N3 stage, or positive margins)...
August 18, 2016: JAMA Otolaryngology—Head & Neck Surgery
Susanne Kaiser, Cetina Thiel, Martin Kramer, Christine Peppler
OBJECTIVE: Evaluation of intra- and postoperative complications and prognosis of cervical sialoceles in the dog when using the lateral surgical approach for extirpation of the mandibular and sublingual salivary glands. MATERIAL AND METHODS: Medical records of 16 dogs with 19 sialoceles were evaluated retrospectively. Long-term follow-up was evaluated by telephone questionnaire to the owners or the referring veterinarian. The surgical technique is depicted in detail...
October 12, 2016: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
Saskia E Kok, Jan J W van der Burg, Karen van Hulst, Corrie E Erasmus, Frank J A van den Hoogen
OBJECTIVE: The aim of this study was to evaluate the impact of a reduction in drooling after bilateral submandibular duct relocation (SMDR) with sublingual gland excision on daily life and care, as well as social and emotional consequences in children and adolescents with neurodevelopmental disabilities. METHODS: This prospective cohort study included 72 children and adolescents (46 males, 26 females) with moderate to severe drooling, and their caregivers. Mean age at the time of surgery was 15 years 2 months (SD 4y 3mo)...
September 2016: International Journal of Pediatric Otorhinolaryngology
A Hills, A Holden, M McGurk
Excision of the sublingual gland is the traditional cure for ranulas, but is invasive with considerable morbidity. We report techniques that have been developed to minimise this by targeting their specific pathophysiology, which include an intraoral approach to plunging ranulas, and gland-preserving selective excision with a highly conservative suture technique for simple ranulas. Fifty-four ranulas in 53 (20 male and 33 female, mean age 29 (range 7-57) years) consecutive patients were treated by a single surgeon between 2001-14 and their records reviewed retrospectively...
July 23, 2016: British Journal of Oral & Maxillofacial Surgery
Diana Terlević Dabić, Sanja Jurišić, Vanja Vučićević Boras, Dragana Gabrić, Ivona Bago, Danko Velimir Vrdoljak
OBJECTIVE: The aim of this study was to compare switched on and switched off (sham) low-level laser therapy (LLLT) in the treatment of drug-induced hyposalivation. BACKGROUND DATA: Hyposalivation is decreased salivary flow rate most frequently present in patients who take a lot of medication, suffer from Sjögren's syndrome, or were irradiated. Available therapies provide only short-term relief. MATERIALS AND METHODS: Forty-three participants (40 females and 3 males, average age 72...
September 2016: Photomedicine and Laser Surgery
P Sheshadri, T M Kalappa, B Pramod Krishna, Santhosh Kumaran, M A Lakshith Biddappa
Diagnosis of midline neck swellings may give a myriad of options, ranging from ranula, thyroglossal duct cyst, cystic hygroma, cystic lymphangioma, epidermoid, dermoid and teratoid cysts to benign or malignant neoplasms of the mucosa or salivary glands and also rare skin appendage tumours like pilomatricoma or pilomatrix carcinoma. Various pitfalls are encountered in diagnosing these midline swellings as most of the features are overlapping. Careful history and examination have to be complemented with other diagnostic aids such as conventional radiography, ultrasonography, aspiration cytology and computed tomography to arrive at a correct diagnosis...
July 2016: Journal of Maxillofacial and Oral Surgery
Sahejmeet S Guraya, Richard A Prayson
Primary salivary gland peripheral nerve sheath tumors (PNST) are uncommon. This study is a retrospective, clinicopathologic review of 9 cases of PNST (5 neurofibromas, 3 schwannomas and 1 malignant peripheral nerve sheath tumor (MPNST)) arising from the salivary glands, encountered between 1990 and 2015. All patients with neurofibromas were male (ages 1-62 years) and had a single parotid lesion of which 2 were diffuse, 2 plexiform and one mixed diffuse/plexiform. Four had a history of neurofibromatosis I. Four of 5 presented with symptoms related to mass effect including facial swelling, facial drooping, and dysphagia...
August 2016: Annals of Diagnostic Pathology
Graham Wood, Nazlie Syyed, Craig Wales
We describe an anatomical and simple technique for the removal of the submandibular gland that has good outcomes and minimal complications.
July 4, 2016: British Journal of Oral & Maxillofacial Surgery
Yuko Matoba, Naoko Nonaka, Yoshitoki Takagi, Eisaku Imamura, Masayuki Narukawa, Tomoya Nakamachi, Seiji Shioda, William A Banks, Masanori Nakamura
Xerostomia, or dry mouth, is a common syndrome that is generally treated with artificial saliva; however, no other effective methods have yet been established. Saliva secretion is mainly under the control of the autonomic nervous system. Pituitary adenylate cyclase-activating polypeptide (PACAP) is recognized as a multifunctional neuropeptide in various organs. In this study, we examined the effect of PACAP on saliva secretion, and detected the distribution of the PACAP type 1 receptor (PAC1R) in major salivary glands, including the parotid, submandibular, and sublingual glands, in 9-week-old male C57BL/6 mice...
September 2016: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
Sirin Mneimneh, Randa Barazi, Mariam Rajab
Ranula is a mucus extravasation cyst originating from the sublingual gland on the floor of the mouth. Congenital ranula is very rare. We report a case of a 4-month-old girl with a congenital ranula in the floor of mouth. The ranula was treated first by marsupialization, but the cyst recurred after 1 week. Excision of the ranula was done and was successful.
2016: Case Reports in Otolaryngology
Tewarat Kumchantuek, Hiroki Nakata, Natthiya Sakulsak, Miyuki Yamamoto, Shoichi Iseki
OBJECTIVES: Calpains comprise a family of intracellular Ca(2+)-dependent cysteine proteases and are considered to play roles in various physiological phenomena with limited proteolytic activities against specific substrates. We herein revealed the expression and localization of calpain 3, the muscle-type calpain, in the submandibular gland (SMG) of mice. DESIGN: The expression of the mRNA for conventional, ubiquitous calpains 1 and 2 and skeletal muscle-specific calpain 3 was examined in the major salivary glands of mice using RT-PCR, and the expression and localization of calpain 3 protein was examined in the SMG of mice using immunohistochemistry and Western blotting...
May 31, 2016: Archives of Oral Biology
Suna Aydin, Mehmet Nesimi Eren, Musa Yilmaz, Mehmet Kalayci, Meltem Yardim, Omer Dogan Alatas, Tuncay Kuloglu, Huseyin Balaban, Tolga Cakmak, Mehmet Ali Kobalt, Ahmet Çelik, Suleyman Aydin
AIM: Enzyme-positive acute coronary syndrome (EPACS) can cause injury to or death of the heart muscle owing to prolonged ischaemia. Recent research has indicated that in addition to liver and brain cells, cardiomyocytes also produce adropin. We hypothesised that adropin is released into the bloodstream during myocardial injury caused by acute coronary syndrome (ACS), so serum and saliva levels rise as the myocytes die. Therefore, it could be useful to investigate how ACS affects the timing and significance of adropin release in human subjects...
May 19, 2016: Cardiovascular Journal of Africa
Hyung Chae Yang, Si Yoen Kim, Sun Kyung Kim, Chang Seok Oh, In Hyuk Chung, Kwang Il Nam
The purpose of this study was to document the presence of a sublingual gland (SLG) herniating inferiorly through the mylohyoid muscle into the submandibular area. A total of 100 half-heads of 50 adult Korean cadavers were enrolled in this study. The floor of the mouth was dissected from the neck, and mylohyoid muscle patency and position of the sublingual gland were evaluated. Demographic factors of the donor and characteristics of the herniation were evaluated. Herniation was found in 29 (58.0 %) of the 50 cadavers or 42 of the 100 half-heads...
May 14, 2016: European Archives of Oto-rhino-laryngology
Julio Guerrero-Hernández, Norma Moreno-Mendoza
Bats constitute one of the most numerous mammalian species. Bats have a wide range of dietary habits and include carnivorous, haematophagous, insectivorous, frugivorous and nectivorous species. The salivary glands of these species have been of particular research interest due to their structural variability among chiropterans with different types of diets. Myoepithelial cells (MECs), which support and facilitate the expulsion of saliva from the secretory portions of salivary glands, are very important for their function; however, this cell type has not been extensively studied in the salivary glands of bats...
August 2016: Journal of Anatomy
Kunio Yoshizawa, Akinori Moroi, Shuichi Kawashiri, Koichiro Ueki
A ranula is a mucus retention cyst or pseudocyst caused by leakage of mucus from the sublingual gland and generally occurs in the oral floor. In addition, drug induced hypersensitivity syndrome (DIHS) is a rare but well-recognized serious adverse effect characterized by fever, skin rashes, generalized lymphadenopathy, hepatitis, and hepatosplenomegaly and oral stomatitis. This paper presents the first case of successfully treated sublingual ranula with localized injection of OK-432 after healing from drug induced hypersensitivity syndrome, which has previously been unreported in the literature...
2016: Case Reports in Dentistry
Vincenzo De Sanctis, Ashraf T Soliman, Salvatore Di Maio, Heba Elsedfy, Nada A Soliman, Rania Elalaily
Thyroid hemiagenesis (TH) is a rare congenital abnormality of the thyroid gland, characterised by the absence of one lobe. The true prevalence of this congenital abnormality is not known because the absence of one thyroid lobe usually does not cause clinical symptoms by itself. Between 1970 and 2010, 329 cases of TH have been reported. It is interesting to note that most cases have an agenesis of the left lobe (80% of cases) followed by the isthmus (44-50% of cases). Although the female to male ratio was 1:1...
March 2016: Pediatric Endocrinology Reviews: PER
Patrick J Bradley, Robert L Ferris
Malignant sublingual gland neoplasms are rare, early-stage neoplasms presenting as painless non-ulcerated masses in the antero-lateral floor of the mouth. The majority of patients present with advanced disease, with symptoms of pain or anaesthesia of the tongue. Malignant minor salivary gland neoplasms are more common, the majority (>80%) of which present in the oral cavity, most frequently in the palatal area, as painless masses or as obstructive symptoms in the head and neck region. The most frequent pathologies are adenoid cystic carcinoma and mucoepidermoid carcinoma (>85%), with the majority presenting at an advanced stage (III/IV)...
2016: Advances in Oto-rhino-laryngology
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