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JOURNAL ARTICLE
Madhumitha Rabindranath, Maryam Naghibzadeh, Xun Zhao, Sandra Holdsworth, Michael Brudno, Aman Sidhu, Mamatha Bhat
Medical applications of machine learning (ML) have shown promise in analyzing patient data to support clinical decision-making and provide patient-specific outcomes. In transplantation, several applications of ML exist which include pretransplant: patient prioritization, donor-recipient matching, organ allocation, and posttransplant outcomes. Numerous studies have shown the development and utility of ML models, which have the potential to augment transplant medicine. Despite increasing efforts to develop robust ML models for clinical use, very few of these tools are deployed in the healthcare setting...
December 7, 2023: Transplantation
#22
JOURNAL ARTICLE
Mandy K Salmon, Rijul S Kshirsagar, Jacob G Eide, Auddie M Sweis, Kathleen Davin, Aman Prasad, Heather Ungerer, Elizabeth Stevens, Kevin Ig-Izevbekhai, Siddhant Tripathi, Tran B Locke, Theodore Lin, Brian M Sweis, Michael A Kohanski, Nithin D Adappa, James N Palmer
OBJECTIVES: The use of topical corticosteroids to manage postoperative sinonasal symptoms after endoscopic skull base surgery (ESBS) has not been well studied. We quantified long-term impact of postoperative steroid irrigations (SIs) on quality of life of patients after ESBS. METHODS: Retrospective review of patients at the University of Pennsylvania undergoing ESBS from 2010 to 2019. Data on patient demographics and postoperative treatment with nasal saline irrigation twice daily with and without dissolved steroids (mometasone or budesonide) was collected...
December 2023: World Journal of Otorhinolaryngology—Head and Neck Surgery
#23
Cleanthis Michael, Aman Taxali, Mike Angstadt, Omid Kardan, Alexander Weigard, M Fiona Molloy, Katherine L McCurry, Luke W Hyde, Mary M Heitzeg, Chandra Sripada
Socioeconomic resources (SER) calibrate the developing brain to the current context, which can confer or attenuate risk for psychopathology across the lifespan. Recent multivariate work indicates that SER levels powerfully influence intrinsic functional connectivity patterns across the entire brain. Nevertheless, the neurobiological meaning of these widespread alterations remains poorly understood, despite its translational promise for early risk identification, targeted intervention, and policy reform. In the present study, we leverage the resources of graph theory to precisely characterize multivariate and univariate associations between household SER and the functional integration and segregation (i...
November 13, 2023: bioRxiv
#24
REVIEW
Shreyas Bellur, Atulya Aman Khosla, Ahmad Ozair, Rupesh Kotecha, Michael W McDermott, Manmeet S Ahluwalia
Brain metastases (BMs) represent the most common intracranial tumors in adults, and most commonly originate from lung, followed by breast, melanoma, kidney, and colorectal cancer. Management of BM is individualized based on the size and number of brain metastases, the extent of extracranial disease, the primary tumor subtype, neurological symptoms, and prior lines of therapy. Until recently, treatment strategies were limited to local therapies, like surgical resection and radiotherapy, the latter in the form of whole-brain radiotherapy or stereotactic radiosurgery...
December 2023: Seminars in Neurology
#25
JOURNAL ARTICLE
David Hough, Alice R Mao, Michael Aman, Reymundo Lozano, Constance Smith-Hicks, Veronica Martinez-Cerdeno, Michael Derby, Zachary Rome, Niel Malan, Robert L Findling
BACKGROUND: There is a critical need for effective treatment of the core symptoms of autism spectrum disorder (ASD). The purinergic antagonist suramin may improve core symptoms through restoration of normal mitochondrial function and reduction of neuro-inflammation via its known antagonism of P2X and P2Y receptors. Nonclinical studies in fragile X knockout mice and the maternal immune activation model support these hypotheses. METHODS: We conducted a 14 week, randomized, double-blind, placebo-controlled proof -of-concept study (N = 52) to test the efficacy and safety of suramin intravenous infusions in boys aged 4-15 years with moderate to severe ASD...
November 6, 2023: Annals of General Psychiatry
#26
JOURNAL ARTICLE
Meghan E Hill, Luke A Johnson, Jing Wang, David Escobar Sanabria, Rémi Patriat, Scott E Cooper, Michael C Park, Noam Harel, Jerrold L Vitek, Joshua E Aman
BACKGROUND: Excessive subthalamic nucleus (STN) β-band (13-35 Hz) synchronized oscillations has garnered interest as a biomarker for characterizing disease state and developing adaptive stimulation systems for Parkinson's disease (PD). OBJECTIVES: To report on a patient with abnormal treatment-responsive modulation in the β-band. METHODS: We examined STN local field potentials from an externalized deep brain stimulation (DBS) lead while assessing PD motor signs in four conditions (OFF, MEDS, DBS, and MEDS+DBS)...
October 27, 2023: Movement Disorders: Official Journal of the Movement Disorder Society
#27
JOURNAL ARTICLE
Jose Danilo Bengzon Diestro, Mahmoud Dibas, Nimer Adeeb, Robert W Regenhardt, Justin E Vranic, Adrien Guenego, Sovann V Lay, Leonardo Renieri, Ali Al Balushi, Eimad Shotar, Kévin Premat, Kareem El Namaani, Guillaume Saliou, Markus A Möhlenbruch, Ivan Lylyk, Paul M Foreman, Jay A Vachhani, Vedran Župančić, Muhammad U Hafeez, Caleb Rutledge, Hamid Rai, Vincent M Tutino, Shervin Mirshahi, Sherief Ghozy, Pablo Harker, Naif M Alotaibi, James D Rabinov, Yifan Ren, Clemens M Schirmer, Oded Goren, Mariangela Piano, Anna L Kühn, Caterina Michelozzi, Stéphanie Elens, Robert M Starke, Ameer E Hassan, Arsalaan Salehani, Anh Nguyen, Jesse Jones, Marios Psychogios, Julian Spears, Thomas Marotta, Vitor Pereira, Carmen Parra-Fariñas, Maria Bres-Bullrich, Michael Mayich, Mohamed M Salem, Jan-Karl Burkhardt, Brian T Jankowitz, Ricardo A Domingo, Thien Huynh, Rabih Tawk, Christian Ulfert, Boris Lubicz, Pietro Panni, Ajit S Puri, Guglielmo Pero, Christoph J Griessenauer, Hamed Asadi, Adnan Siddiqui, Andrew F Ducruet, Felipe C Albuquerque, Nirav Patel, Peter Kan, Vladimir Kalousek, Pedro Lylyk, Srikanth Boddu, Christopher J Stapleton, Jared Knopman, Pascal Jabbour, Stavropoula Tjoumakaris, Frédéric Clarençon, Nicola Limbucci, Mohammad A Aziz-Sultan, Hugo H Cuellar-Saenz, Christophe Cognard, Aman B Patel, Adam A Dmytriw
OBJECTIVE: The Woven EndoBridge (WEB) device is an intrasaccular flow disruptor designed for wide-necked bifurcation aneurysms. These aneurysms may require the use of a concomitant stent. The objective of this study was to determine the clinical and radiological outcomes of patients undergoing stent-assisted WEB treatment. In addition, the authors also sought to determine the predictors of a concomitant stent in aneurysms treated with the WEB device. METHODS: The data for this study were taken from the WorldWideWEB Consortium, an international multicenter cohort including patients treated with the WEB device...
October 20, 2023: Journal of Neurosurgery
#28
JOURNAL ARTICLE
Heike A Bischoff-Ferrari, Michael Gagesch, Dai-Hua Tsai, Clara Richter, Patricia Lanz, Patrick Sidler, Uenal Can, Dagmar I Keller, Markus Minder, Bettina von Rickenbach, Ali Yildirim-Aman, Katharina Geiling, Gregor Freystaetter
BACKGROUND: The growing number of older and oldest-old patients often present in the emergency room (ER) with undiagnosed geriatric syndromes posing them at high risk for complications in acute care. OBJECTIVE: To develop and validate an ER screening tool (ICEBERG) to capture 9 geriatric domains of risk in older patients. DESIGN SETTING AND PARTICIPANTS: For construct validity we performed a chart-based study in 129 ER patients age 70 years and older admitted to acute geriatric care (pilot 1)...
2023: Frontiers in Medicine
#29
REVIEW
Amir Mbonde, Michael J Young, Adam A Dmytriw, Quentin J Moyer, Joshua A Hirsch, Thabele M Leslie-Mazwi, Natalia S Rost, Aman B Patel, Robert W Regenhardt
IMPORTANCE: Informed consent (IC) plays a crucial yet underexplored role in acute stroke treatment, particularly in the context of intravenous thrombolysis (IVT) and endovascular thrombectomy (EVT). This narrative review examines data on current IC practices in acute ischemic stroke management, specifically for patients treated with IVT or EVT, with the aim of identifying areas for improvement and strategies to enhance the IC process. OBSERVATIONS: IC practices for IVT vary significantly among hospitals and physicians with the frequency of always requiring consent ranging from 21 to 37%...
October 10, 2023: Journal of Neurology
#30
JOURNAL ARTICLE
Valentina Zapata Amaya, Joshua E Aman, Luke A Johnson, Jing Wang, Remi Patriat, Meghan E Hill, Colum D MacKinnon, Scott E Cooper, David Darrow, Robert McGovern, Noam Harel, Gregory F Molnar, Michael C Park, Jerrold L Vitek, David Escobar Sanabria
INTRODUCTION: Evidence suggests that spontaneous beta band (11-35 Hz) oscillations in the basal ganglia thalamocortical (BGTC) circuit are linked to Parkinson's disease (PD) pathophysiology. Previous studies on neural responses in the motor cortex evoked by electrical stimulation in the subthalamic nucleus have suggested that circuit resonance may underlie the generation of spontaneous and stimulation-evoked beta oscillations in PD. Whether these stimulation-evoked, resonant oscillations are present across PD patients in the internal segment of the globus pallidus (GPi), a primary output nucleus in the BGTC circuit, is yet to be determined...
2023: Frontiers in Human Neuroscience
#31
JOURNAL ARTICLE
Jaydira Del Rivero, Kimberly Perez, Erin B Kennedy, Erik S Mittra, Namrata Vijayvergia, Junaid Arshad, Sandip Basu, Aman Chauhan, Arvind N Dasari, Andrew M Bellizzi, Alexandra Gangi, Erin Grady, James R Howe, Jana Ivanidze, Mark Lewis, Josh Mailman, Nitya Raj, Heloisa P Soares, Michael C Soulen, Sarah B White, Jennifer A Chan, Pamela L Kunz, Simron Singh, Thorvardur R Halfdanarson, Jonathan R Strosberg, Emily K Bergsland
PURPOSE: To develop recommendations for systemic therapy for well-differentiated grade 1 (G1) to grade 3 (G3) metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NETs). METHODS: ASCO convened an Expert Panel to conduct a systematic review of relevant studies and develop recommendations for clinical practice. RESULTS: Eight randomized controlled trials met the inclusion criteria for the systematic review. RECOMMENDATIONS: Somatostatin analogs (SSAs) are recommended as first-line systemic therapy for most patients with G1-grade 2 (G2) metastatic well-differentiated GI-NETs...
November 10, 2023: Journal of Clinical Oncology
#32
JOURNAL ARTICLE
Anna Laddach, Song Hui Chng, Reena Lasrado, Fränze Progatzky, Michael Shapiro, Alek Erickson, Marisol Sampedro Castaneda, Artem V Artemov, Ana Carina Bon-Frauches, Eleni-Maria Amaniti, Jens Kleinjung, Stefan Boeing, Sila Ultanir, Igor Adameyko, Vassilis Pachnis
Glial cells have been proposed as a source of neural progenitors, but the mechanisms underpinning the neurogenic potential of adult glia are not known. Using single cell transcriptomic profiling, we show that enteric glial cells represent a cell state attained by autonomic neural crest cells as they transition along a linear differentiation trajectory that allows them to retain neurogenic potential while acquiring mature glial functions. Key neurogenic loci in early enteric nervous system progenitors remain in open chromatin configuration in mature enteric glia, thus facilitating neuronal differentiation under appropriate conditions...
September 22, 2023: Nature Communications
#33
LETTER
Michael P Schnetz, Aman Mahajan
No abstract text is available yet for this article.
October 1, 2023: Anesthesia and Analgesia
#34
JOURNAL ARTICLE
Qingqing Gu, Aman Kumar, Michael Hook, Fuyi Xu, Akhilesh Kumar Bajpai, Athena Starlard-Davenport, Junming Yue, Monica M Jablonski, Lu Lu
PURPOSE: Glaucoma is a group of heterogeneous optic neuropathies characterized by the progressive degeneration of retinal ganglion cells. However, the underlying mechanisms have not been understood completely. We aimed to elucidate the genetic network associated with the development of pigmentary glaucoma with DBA/2J (D2) mouse model of glaucoma and corresponding genetic control D2-Gpnmb (D2G) mice carrying the wild type (WT) Gpnmb allele. METHODS: Retinas isolated from 13 D2 and 12 D2G mice were subdivided into 2 age groups: pre-onset (1-6 months: samples were collected at approximately 1-2, 2-4, and 5-6 months) and post-onset (7-15 months: samples were collected at approximately 7-9, 10-12, and 13-15 months) glaucoma were compared...
September 1, 2023: Investigative Ophthalmology & Visual Science
#35
JOURNAL ARTICLE
Jacob T Beckley, Teresa K Aman, Michael A Ackley, Tatiana M Kazdoba, Michael C Lewis, Anne C Smith, Brandon J Farley, Jing Dai, Wayne Deats, Ethan Hoffmann, Albert J Robichaud, James J Doherty, Michael C Quirk
BACKGROUND AND PURPOSE: Select neuroactive steroids (NAS) tune neural activity by modulating excitatory and inhibitory neurotransmission, including the endogenous cholesterol metabolite 24(S)-hydroxycholesterol (24(S)-HC), which is a N-methyl-d-aspartate receptor (NMDAR) positive allosteric modulator (PAM). NMDAR PAMs are potentially an effective pharmacotherapeutic strategy to treat conditions associated with NMDAR hypofunction. EXPERIMENTAL APPROACHES: Using in vitro and in vivo electrophysiological recording experiments and behavioral approaches, we evaluated the effect of SAGE-718, a novel NAS NMDAR PAM currently in clinical development for the treatment of cognitive impairment, on NMDAR function and endpoints that are altered by NMDAR hypoactivity, and assessed its safety profile...
September 12, 2023: British Journal of Pharmacology
#36
JOURNAL ARTICLE
Lauren Katz, Taira Kiyota, Michael Woolman, Megan Wu, Layla Pires, Alexa Fiorante, Lan Anna Ye, Wey Leong, Hal K Berman, Danny Ghazarian, Howard J Ginsberg, Sunit Das, Ahmed Aman, Arash Zarrine-Afsar
Rapid molecular profiling of biological tissues with picosecond infrared laser mass spectrometry (PIRL-MS) has enabled the detection of clinically important histologic types and molecular subtypes of human cancers in as little as 10 s of data collection and analysis time. Utilizing an engineered cell line model of actionable BRAF-V600E mutation, we observed statistically significant differences in 10 s PIRL-MS molecular profiles between BRAF-V600E and BRAF-wt cells. Multivariate statistical analyses revealed a list of mass-to-charge ( m / z ) values most significantly responsible for the identification of BRAF-V600E mutation status in this engineered cell line that provided a highly controlled testbed for this observation...
September 11, 2023: Analytical Chemistry
#37
JOURNAL ARTICLE
Kareem El Naamani, Ching-Jen Chen, Roland Jabre, Hassan Saad, Jonathan A Grossberg, Adam A Dmytriw, Aman B Patel, Mirhojjat Khorasanizadeh, Christopher S Ogilvy, Ajith Thomas, Andre Monteiro, Adnan Siddiqui, Gustavo M Cortez, Ricardo A Hanel, Guilherme Porto, Alejandro M Spiotta, Anthony J Piscopo, David M Hasan, Mohammad Ghorbani, Joshua Weinberg, Shahid M Nimjee, Kimon Bekelis, Mohamed M Salem, Jan-Karl Burkhardt, Akli Zetchi, Charles Matouk, Brian M Howard, Rosalind Lai, Rose Du, Rawad Abbas, Georgios S Sioutas, Abdelaziz Amllay, Alfredo Munoz, Elias Atallah, Nabeel A Herial, Stavropoula I Tjoumakaris, Michael Reid Gooch, Robert H Rosenwasser, Pascal Jabbour
BACKGROUND: Moyamoya is a chronic occlusive cerebrovascular disease of unknown etiology causing neovascularization of the lenticulostriate collaterals at the base of the brain. Although revascularization surgery is the most effective treatment for moyamoya, there is still no consensus on the best surgical treatment modality as different studies provide different outcomes. OBJECTIVE: In this large case series, we compare the outcomes of direct (DR) and indirect revascularisation (IR) and compare our results to the literature in order to reflect on the best revascularization modality for moyamoya...
September 6, 2023: Journal of Neurology, Neurosurgery, and Psychiatry
#38
JOURNAL ARTICLE
Jiayun Yao, Michael A Irvine, Braeden Klaver, Moe Zandy, Aman K Dheri, Eric Grafstein, Kate Smolina
BACKGROUND: Previous studies have shown reductions in the volume of emergency department visits early in the COVID-19 pandemic, but few have evaluated the pandemic's impact over time or stratified analyses by reason for visits. We aimed to quantify such changes in British Columbia, Canada, cumulatively and during prominent nadirs, and by reason for visit, age and acuity. METHODS: We included data from the National Ambulatory Care Reporting System for 30 emergency departments across BC from January 2016 to December 2022...
September 5, 2023: Canadian Medical Association Journal: CMAJ
#39
JOURNAL ARTICLE
Michael P Schnetz, Brian J Reon, James W Ibinson, Murat Kaynar, Aman Mahajan, Keith M Vogt
BACKGROUND: Although patients are commonly monitored for depth of anesthesia, it is unclear to what extent administration of intravenous anesthetic medications may affect calculated bispectral (BIS) index values under general anesthesia. METHODS: In a retrospective analysis of electronic anesthesia records from an academic medical center, we examined BIS index changes associated with 14 different intravenous medications, as administered in routine practice, during volatile-based anesthesia using a novel screening approach...
August 15, 2023: Anesthesia and Analgesia
#40
Eric Nguyen, Michael Poli, Marjan Faizi, Armin Thomas, Callum Birch-Sykes, Michael Wornow, Aman Patel, Clayton Rabideau, Stefano Massaroli, Yoshua Bengio, Stefano Ermon, Stephen A Baccus, Chris Ré
Genomic (DNA) sequences encode an enormous amount of information for gene regulation and protein synthesis. Similar to natural language models, researchers have proposed foundation models in genomics to learn generalizable features from unlabeled genome data that can then be fine-tuned for downstream tasks such as identifying regulatory elements. Due to the quadratic scaling of attention, previous Transformer-based genomic models have used 512 to 4k tokens as context (<0.001% of the human genome), significantly limiting the modeling of long-range interactions in DNA...
June 27, 2023: ArXiv
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