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Michael aman

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https://www.readbyqxmd.com/read/29620914/effects-of-metformin-on-spatial-and-verbal-memory-in-children-with-asd-and-overweight-associated-with-atypical-antipsychotic-use
#1
Michael G Aman, Jill A Hollway, Jeremy Veenstra-VanderWeele, Benjamin L Handen, Kevin B Sanders, James Chan, Eric Macklin, L Eugene Arnold, Taylor Wong, Cassandra Newsom, Rianne Hastie Adams, Sarah Marler, Naomi Peleg, Evdokia A Anagnostou
OBJECTIVES: Studies in humans and rodents suggest that metformin, a medicine typically used to treat type 2 diabetes, may have beneficial effects on memory. We sought to determine whether metformin improved spatial or verbal memory in children with autism spectrum disorder (ASD) and overweight associated with atypical antipsychotic use. METHODS: We studied the effects of metformin (Riomet® ) concentrate on spatial and verbal memory in 51 youth with ASD, ages 6 through 17 years, who were taking atypical antipsychotic medications, had gained significant weight, and were enrolled in a trial of metformin for weight management...
April 5, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29611206/new-insights-into-the-cellular-mechanisms-of-plant-growth-at-elevated-atmospheric-carbon-dioxide
#2
REVIEW
Dananjali Gamage, Michael Thompson, Mark Sutherland, Naoki Hirotsu, Amane Makino, Saman Seneweera
Rising atmospheric carbon dioxide concentration ([CO2 ]) significantly influences plant growth, development and biomass. Increased photosynthesis rate, together with lower stomatal conductance, have been identified as the key factors that stimulate plant growth at elevated [CO2 ] (e[CO2 ]). However, variations in photosynthesis and stomatal conductance alone cannot fully explain the dynamic changes in plant growth. Stimulation of photosynthesis at e[CO2 ] is always associated with post-photosynthetic secondary metabolic processes that include carbon and nitrogen metabolism, cell cycle functions and hormonal regulation...
April 2, 2018: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29600785/utility-of-the-electrocardiogram-in-mapping-of-atrial-tachycardia-post-atrial-fibrillation-ablation-back-to-the-basics
#3
EDITORIAL
Michael Ghannam, Aman Chugh
No abstract text is available yet for this article.
January 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29581792/inhaled-immunotherapy-administration-for-lung-cancer-efficient-certainly-possible
#4
Konstantinos Sapalidis, Paul Zarogoulidis, Haidong Huang, Chong Bai, Yuting Wen, Li Wang, Konstantina Boniou, Ilias Karapantzos, Chrysanthi Karapantzou, Michael Karanikas, Vasilis Thomaidis, Christoforos Kosmidis, Chrysanthi Sardeli, Naim Benhassen, Yan-Gao Man, Maria C Florou, Stylianos Mantalovas, Stella Laskou, Dimitris Giannakidis, Charilaos Koulouris, Aikaterini Amaniti, Isaak Kesisoglou, Wolfgang Hohenforst-Schmidt
Lung cancer is still diagnosed at a late stage in most lung cancer patients. Regarding Non-small Cell lung cancer there are novel therapies such as; tyrosine kinase inhibitors and immunotherapy. Currently we have two immunotherapies that can be used either as first-line treatment or second line treatment; pembrolizumab and nivolumab. A third one is being investigated as a combination of immunotherapy; ipilimumab. Aerosol treatment has been investigated for many diseases not only for the lung, but also for systematic diseases...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29581760/a-new-and-safe-mode-of-ventilation-for-interventional-pulmonary-medicine-the-ease-of-nasal-superimposed-high-frequency-jet-ventilation
#5
Wolfgang Hohenforst-Schmidt, Paul Zarogoulidis, Haidong Huang, Yan-Gao Man, Stella Laskou, Charilaos Koulouris, Dimitris Giannakidis, Stylianos Mantalobas, Maria C Florou, Aikaterini Amaniti, Michael Steinheimer, Anil Sinha, Lutz Freitag, J Francis Turner, Robert Browning, Thomas Vogl, Andrei Roman, Naim Benhassen, Isaak Kesisoglou, Konstantinos Sapalidis
We use pulmonary interventional procedures for the diagnosis of pulmonary diseases either for benign or malignant lesions. Flexible bronchoscopy with or without radial endobronchial ultrasound, convex-probe endobronchial ultrasound and electromagnetic navigation are procedures performed in centers with experience in diagnostic pulmonary medicine. The method of sedation and ventilation is very important in order to avoid or handle with success complications. Proper respiration during pulmonary (or other interventional) procedures is a key factor...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29502686/big-data-progress-or-a-big-headache
#6
EDITORIAL
Aman Dhawan, Jefferson C Brand, Michael J Rossi, James H Lubowitz
Large administrative database, or "big data" research studies can include an immense number of patients. Strengths of research based on big data include generalizability resulting from diverse patients, diverse providers, and diverse clinical settings. Limitations of research based on large administrative databases may include indeterminate quality and obscure purpose of data entry, lack of information regarding confounding variables, and suboptimal clinical outcome measures. Thus, research conclusions based on big data must be scrutinized in a discerning and critical manner...
March 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29485877/gas-hydrate-formation-probability-distributions-the-effect-of-shear-and-comparisons-with-nucleation-theory
#7
Eric F May, Vincent W Lim, Peter J Metaxas, Jianwei Du, Paul L Stanwix, Darren Rowland, Michael L Johns, Gert Haandrikman, Daniel Crosby, Zachary M Aman
Gas hydrate formation is a stochastic phenomenon of considerable significance for any risk-based approach to flow assurance in the oil and gas industry. In principle, well-established results from nucleation theory offer the prospect of predictive models for hydrate formation probability in industrial production systems. In practice, however, heuristics are relied on when estimating formation risk for a given flowline subcooling or when quantifying kinetic hydrate inhibitor (KHI) performance. Here, we present statistically significant measurements of formation probability distributions for natural gas hydrate systems under shear, which are quantitatively compared with theoretical predictions...
February 27, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29430408/using-bronchoscopy-to-detect-acquired-tracheoesophageal-fistula-in-mechanically-ventilated-patients
#8
Michael S Green, Johann J Mathew, Lia J Michos, Parmis Green, Mansoor M Aman
Introduction: An acquired Tracheoesophageal fistula (TEF) is commonly caused by a malignancy or trauma, with pulmonary infection or aspiration being the presenting symptom. However, in the critical care setting the presentation can be subtle and may present with difficult ventilation. High endotracheal tube cuff pressures can lead to tracheal erosions and thus increasing the chances for developing a TEF. Prolonged intubation in the presence of other risk factors like poor general state of health, episodic hypotension, nasogastric tubes, and repeated intubations can increase the likelihood of developing an acquired TEF...
August 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/29400810/innovative-scheme-for-high-repetition-rate-imaging-of-cn-radical
#9
Aman Satija, Morgan D Ruesch, Michael S Powell, Steven F Son, Robert P Lucht
We have employed, to the best of our knowledge, a novel excitation scheme to perform the first high-repetition-rate planar laser-induced fluorescence (PLIF) measurements of a CN radical in combustion. The third harmonic of a Nd:YVO4 laser at 355 nm due to its relatively large linewidth overlaps with several R branch transitions in a CN ground electronic state. Therefore, the 355 nm beam was employed to directly excite the CN transitions with good efficiency. The CN measurements were performed in premixed CH4-N2O flames with varying equivalence ratios...
February 1, 2018: Optics Letters
https://www.readbyqxmd.com/read/29173736/clinical-implications-from-the-treatment-of-severe-childhood-aggression-tosca-study-a-re-analysis-and-integration-of-findings
#10
RANDOMIZED CONTROLLED TRIAL
Justin A Barterian, L Eugene Arnold, Nicole V Brown, Cristan A Farmer, Craig Williams, Robert L Findling, David J Kolko, Oscar G Bukstein, Brooke S G Molina, Lisa Townsend, Michael G Aman
OBJECTIVE: The Treatment of Severe Childhood Aggression (TOSCA) project examined augmentation of stimulant treatment and parent training (PT) with risperidone for severe physical aggression. This article summarizes the clinical implications; reanalyzes the data to examine the utility of 4 criteria for deciding to augment; and presents a treatment algorithm. METHOD: The newly analyzed 4 criteria for augmenting after 3 weeks of stimulant and PT treatment consisted of not meeting a Clinical Global Impressions-Improvement (CGI-I) score of 1 and a normal score (≤15) on the Nisonger Child Behavior Rating Form Disruptive-Total (D-Total); a CGI-I score of 1 or 2 plus 25% improvement in D-Total score; a D-Total score no higher than 15; and a CGI-Severity score of 3 (mild) or better...
December 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29118211/sensation-during-active-behaviors
#11
REVIEW
Laura Busse, Jessica A Cardin, M Eugenia Chiappe, Michael M Halassa, Matthew J McGinley, Takayuki Yamashita, Aman B Saleem
A substantial portion of our sensory experience happens during active behaviors such as walking around or paying attention. How do sensory systems work during such behaviors? Neural processing in sensory systems can be shaped by behavior in multiple ways ranging from a modulation of responsiveness or sharpening of tuning to a dynamic change of response properties or functional connectivity. Here, we review recent findings on the modulation of sensory processing during active behaviors in different systems: insect vision, rodent thalamus, and rodent sensory cortices...
November 8, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29112459/atomoxetine-parent-training-and-their-effects-on-sleep-in-youth-with-autism-spectrum-disorder-and-attention-deficit-hyperactivity-disorder
#12
Jill A Hollway, Marrisa Mendoza-Burcham, Rebecca Andridge, Michael G Aman, Benjamin Handen, L Eugene Arnold, Luc Lecavalier, Craig Williams, Laura Silverman, Tristram Smith
OBJECTIVE: Sleep disturbance is often a problem for children with either autism spectrum disorder (ASD) or attention-deficit/hyperactivity disorder (ADHD). Psychostimulant medications used to treat ADHD symptoms can exacerbate this problem. For children with ASD and ADHD, atomoxetine (ATX) is a viable alternative to psychostimulants. We investigated the effects of ATX and a manualized parent training (PT) program targeting noncompliance, on the sleep quality of children with ASD and ADHD...
November 7, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29022125/parent-stress-in-a-randomized-clinical-trial-of-atomoxetine-and-parent-training-for-children-with-autism-spectrum-disorder
#13
Luc Lecavalier, Xueliang Pan, Tristram Smith, Benjamin L Handen, L Eugene Arnold, Laura Silverman, Rameshwari V Tumuluru, Jill Hollway, Michael G Aman
We previously reported a 2 × 2 randomized clinical trial of atomoxetine (ATX) and parent training (PT) for attention deficit hyperactivity disorder (ADHD) symptoms and behavioral noncompliance in 128 children with autism spectrum disorder, ages 5-14 years. Children were randomized to one of four conditions: ATX alone, placebo alone, ATX + PT, or PT + placebo. Both ATX and PT improved some indices of ADHD and behavioral compliance. In this report, we describe parent stress over time and across conditions...
October 11, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28989676/rapid-determination-of-medulloblastoma-subgroup-affiliation-with-mass-spectrometry-using-a-handheld-picosecond-infrared-laser-desorption-probe
#14
Michael Woolman, Isabelle Ferry, Claudia M Kuzan-Fischer, Megan Wu, Jing Zou, Taira Kiyota, Semra Isik, Delaram Dara, Ahmed Aman, Sunit Das, Michael D Taylor, James T Rutka, Howard J Ginsberg, Arash Zarrine-Afsar
Medulloblastoma (MB), the most prevalent malignant childhood brain tumour, consists of at least 4 distinct subgroups each of which possesses a unique survival rate and response to treatment. To rapidly determine MB subgroup affiliation in a manner that would be actionable during surgery, we subjected murine xenograft tumours of two MB subgroups (SHH and Group 3) to Mass Spectrometry (MS) profiling using a handheld Picosecond InfraRed Laser (PIRL) desorption probe and interface developed by our group. This platform provides real time MS profiles of tissue based on laser desorbed lipids and small molecules with only 5-10 seconds of sampling...
September 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28942807/a-randomized-placebo-controlled-trial-of-metformin-for-the-treatment-of-overweight-induced-by-antipsychotic-medication-in-young-people-with-autism-spectrum-disorder-open-label-extension
#15
Benjamin L Handen, Evdokia Anagnostou, Michael G Aman, Kevin B Sanders, James Chan, Jill A Hollway, Jessica Brian, L Eugene Arnold, Lucia Capano, Craig Williams, Jessica A Hellings, Eric Butter, Deepali Mankad, Rameshwari Tumuluru, Jessica Kettel, Cassandra R Newsom, Naomi Peleg, Dina Odrobina, Sarah McAuliffe-Bellin, Sarah Marler, Taylor Wong, Alexis Wagner, Stasia Hadjiyannakis, Eric A Macklin, Jeremy Veenstra-VanderWeele
OBJECTIVE: A previous study reported on a 16-week placebo-controlled, randomized clinical trial (RCT) of metformin for weight stabilization in 61 children and adolescents 6 to 17 years old with autism spectrum disorder who were prescribed atypical antipsychotics. The present study describes the results of a 16-week open-label extension. METHOD: Fifty-two participants from the acute trial (85%) entered the extension; 22 had been on metformin during the initial RCT and 30 had been on placebo...
October 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28831049/treating-the-placenta-to-prevent-adverse-effects-of-gestational-hypoxia-on-fetal-brain-development
#16
Tom J Phillips, Hannah Scott, David A Menassa, Ashleigh L Bignell, Aman Sood, Jude S Morton, Takami Akagi, Koki Azuma, Mark F Rogers, Catherine E Gilmore, Gareth J Inman, Simon Grant, Yealin Chung, Mais M Aljunaidy, Christy-Lynn Cooke, Bruno R Steinkraus, Andrew Pocklington, Angela Logan, Gavin P Collett, Helena Kemp, Peter A Holmans, Michael P Murphy, Tudor A Fulga, Andrew M Coney, Mitsuru Akashi, Sandra T Davidge, C Patrick Case
Some neuropsychiatric disease, including schizophrenia, may originate during prenatal development, following periods of gestational hypoxia and placental oxidative stress. Here we investigated if gestational hypoxia promotes damaging secretions from the placenta that affect fetal development and whether a mitochondria-targeted antioxidant MitoQ might prevent this. Gestational hypoxia caused low birth-weight and changes in young adult offspring brain, mimicking those in human neuropsychiatric disease. Exposure of cultured neurons to fetal plasma or to secretions from the placenta or from model trophoblast barriers that had been exposed to altered oxygenation caused similar morphological changes...
August 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28769755/broadband-prosthetic-interfaces-combining-nerve-transfers-and-implantable-multichannel-emg-technology-to-decode-spinal-motor-neuron-activity
#17
Konstantin D Bergmeister, Ivan Vujaklija, Silvia Muceli, Agnes Sturma, Laura A Hruby, Cosima Prahm, Otto Riedl, Stefan Salminger, Krisztina Manzano-Szalai, Martin Aman, Michael-Friedrich Russold, Christian Hofer, Jose Principe, Dario Farina, Oskar C Aszmann
Modern robotic hands/upper limbs may replace multiple degrees of freedom of extremity function. However, their intuitive use requires a high number of control signals, which current man-machine interfaces do not provide. Here, we discuss a broadband control interface that combines targeted muscle reinnervation, implantable multichannel electromyographic sensors, and advanced decoding to address the increasing capabilities of modern robotic limbs. With targeted muscle reinnervation, nerves that have lost their targets due to an amputation are surgically transferred to residual stump muscles to increase the number of intuitive prosthetic control signals...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28624765/indications-and-appropriate-selection-of-novel-oral-anticoagulants-in-patients-with-atrial-fibrillation
#18
Michael Ghannam, Aman Chugh
No abstract text is available yet for this article.
July 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28614127/a-hospital-is-not-just-a-factory-but-a-complex-adaptive-system-implications-for-perioperative-care
#19
Aman Mahajan, Salim D Islam, Michael J Schwartz, Maxime Cannesson
Many methods used to improve hospital and perioperative services productivity and quality of care have assumed that the hospital is essentially a factory, and therefore, that industrial engineering and manufacturing-derived redesign approaches such as Six Sigma and Lean can be applied to hospitals and perioperative services just as they have been applied in factories. However, a hospital is not merely a factory but also a complex adaptive system (CAS). The hospital CAS has many subsystems, with perioperative care being an important one for which concepts of factory redesign are frequently advocated...
July 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28578761/research-pearls-the-significance-of-statistics-and-perils-of-pooling
#20
EDITORIAL
Aman Dhawan, Jefferson C Brand, Matthew T Provencher, Michael J Rossi, James H Lubowitz
A series of articles on statistics are intended for an audience of clinicians, as well as statisticians and authors. Statistical significance is different than clinical significance. Understanding of clinical outcomes, value, quality, or generalizability requires critical analysis of medical research literature to ensure that statistical analyses have been properly applied and interpreted.
June 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
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