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https://www.readbyqxmd.com/read/29900419/ripping-apart-the-rules-for-peptide-natural-products
#1
Aman S Imani, Michael F Freeman
No abstract text is available yet for this article.
June 2018: Synthetic and Systems Biotechnology
https://www.readbyqxmd.com/read/29860482/global-regional-and-national-cancer-incidence-mortality-years-of-life-lost-years-lived-with-disability-and-disability-adjusted-life-years-for-29-cancer-groups-1990-to-2016-a-systematic-analysis-for-the-global-burden-of-disease-study
#2
Christina Fitzmaurice, Tomi F Akinyemiju, Faris Hasan Al Lami, Tahiya Alam, Reza Alizadeh-Navaei, Christine Allen, Ubai Alsharif, Nelson Alvis-Guzman, Erfan Amini, Benjamin O Anderson, Olatunde Aremu, Al Artaman, Solomon Weldegebreal Asgedom, Reza Assadi, Tesfay Mehari Atey, Leticia Avila-Burgos, Ashish Awasthi, Huda Omer Ba Saleem, Aleksandra Barac, James R Bennett, Isabela M Bensenor, Nickhill Bhakta, Hermann Brenner, Lucero Cahuana-Hurtado, Carlos A Castañeda-Orjuela, Ferrán Catalá-López, Jee-Young Jasmine Choi, Devasahayam Jesudas Christopher, Sheng-Chia Chung, Maria Paula Curado, Lalit Dandona, Rakhi Dandona, José das Neves, Subhojit Dey, Samath D Dharmaratne, David Teye Doku, Tim R Driscoll, Manisha Dubey, Hedyeh Ebrahimi, Dumessa Edessa, Ziad El-Khatib, Aman Yesuf Endries, Florian Fischer, Lisa M Force, Kyle J Foreman, Solomon Weldemariam Gebrehiwot, Sameer Vali Gopalani, Giuseppe Grosso, Rahul Gupta, Bishal Gyawali, Randah Ribhi Hamadeh, Samer Hamidi, James Harvey, Hamid Yimam Hassen, Roderick J Hay, Simon I Hay, Behzad Heibati, Molla Kahssay Hiluf, Nobuyuki Horita, H Dean Hosgood, Olayinka S Ilesanmi, Kaire Innos, Farhad Islami, Mihajlo B Jakovljevic, Sarah Charlotte Johnson, Jost B Jonas, Amir Kasaeian, Tesfaye Dessale Kassa, Yousef Saleh Khader, Ejaz Ahmad Khan, Gulfaraz Khan, Young-Ho Khang, Mohammad Hossein Khosravi, Jagdish Khubchandani, Jacek A Kopec, G Anil Kumar, Michael Kutz, Deepesh Pravinkumar Lad, Alessandra Lafranconi, Qing Lan, Yirga Legesse, James Leigh, Shai Linn, Raimundas Lunevicius, Azeem Majeed, Reza Malekzadeh, Deborah Carvalho Malta, Lorenzo G Mantovani, Brian J McMahon, Toni Meier, Yohannes Adama Melaku, Mulugeta Melku, Peter Memiah, Walter Mendoza, Tuomo J Meretoja, Haftay Berhane Mezgebe, Ted R Miller, Shafiu Mohammed, Ali H Mokdad, Mahmood Moosazadeh, Paula Moraga, Seyyed Meysam Mousavi, Vinay Nangia, Cuong Tat Nguyen, Vuong Minh Nong, Felix Akpojene Ogbo, Andrew Toyin Olagunju, Mahesh Pa, Eun-Kee Park, Tejas Patel, David M Pereira, Farhad Pishgar, Maarten J Postma, Farshad Pourmalek, Mostafa Qorbani, Anwar Rafay, Salman Rawaf, David Laith Rawaf, Gholamreza Roshandel, Saeid Safiri, Hamideh Salimzadeh, Juan Ramon Sanabria, Milena M Santric Milicevic, Benn Sartorius, Maheswar Satpathy, Sadaf G Sepanlou, Katya Anne Shackelford, Masood Ali Shaikh, Mahdi Sharif-Alhoseini, Jun She, Min-Jeong Shin, Ivy Shiue, Mark G Shrime, Abiy Hiruye Sinke, Mekonnen Sisay, Amber Sligar, Muawiyyah Babale Sufiyan, Bryan L Sykes, Rafael Tabarés-Seisdedos, Gizachew Assefa Tessema, Roman Topor-Madry, Tung Thanh Tran, Bach Xuan Tran, Kingsley Nnanna Ukwaja, Vasiliy Victorovich Vlassov, Stein Emil Vollset, Elisabete Weiderpass, Hywel C Williams, Nigus Bililign Yimer, Naohiro Yonemoto, Mustafa Z Younis, Christopher J L Murray, Mohsen Naghavi
Importance: The increasing burden due to cancer and other noncommunicable diseases poses a threat to human development, which has resulted in global political commitments reflected in the Sustainable Development Goals as well as the World Health Organization (WHO) Global Action Plan on Non-Communicable Diseases. To determine if these commitments have resulted in improved cancer control, quantitative assessments of the cancer burden are required. Objective: To assess the burden for 29 cancer groups over time to provide a framework for policy discussion, resource allocation, and research focus...
June 2, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29847298/genetic-risk-for-subsequent-neoplasms-among-long-term-survivors-of-childhood-cancer
#3
Zhaoming Wang, Carmen L Wilson, John Easton, Andrew Thrasher, Heather Mulder, Qi Liu, Dale J Hedges, Shuoguo Wang, Michael C Rusch, Michael N Edmonson, Shawn Levy, Jennifer Q Lanctot, Eric Caron, Kyla Shelton, Kelsey Currie, Matthew Lear, Aman Patel, Celeste Rosencrance, Ying Shao, Bhavin Vadodaria, Donald Yergeau, Yadav Sapkota, Russell J Brooke, Wonjong Moon, Evadnie Rampersaud, Xiaotu Ma, Ti-Cheng Chang, Stephen V Rice, Cynthia Pepper, Xin Zhou, Xiang Chen, Wenan Chen, Angela Jones, Braden Boone, Matthew J Ehrhardt, Matthew J Krasin, Rebecca M Howell, Nicholas S Phillips, Courtney Lewis, Deokumar Srivastava, Ching-Hon Pui, Chimene A Kesserwan, Gang Wu, Kim E Nichols, James R Downing, Melissa M Hudson, Yutaka Yasui, Leslie L Robison, Jinghui Zhang
Purpose Childhood cancer survivors are at increased risk of subsequent neoplasms (SNs), but the germline genetic contribution is largely unknown. We assessed the contribution of pathogenic/likely pathogenic (P/LP) mutations in cancer predisposition genes to their SN risk. Patients and Methods Whole-genome sequencing (30-fold) was performed on samples from childhood cancer survivors who were ≥ 5 years since initial cancer diagnosis and participants in the St Jude Lifetime Cohort Study, a retrospective hospital-based study with prospective clinical follow-up...
May 30, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29805698/monitoring-changes-in-quality-of-life-in-patients-with-lung-cancer-under-treatment-with-chemotherapy-and-co-administration-of-zoledronic-acid-by-using-specialized-questionnaires
#4
Ioannis Tremmas, George Petsatodis, Michael Potoupnis, Stella Laskou, Dimitrios Giannakidis, Stylianos Mantalovas, Charilaos Koulouris, Athanasios Katsaounis, Efstathios Pavlidis, Aikaterini Amaniti, Haidong Huang, Chong Bai, Dongchen Shi, Athanasios Dardas, Paul Zarogoulidis, Chrisanthi Sardeli, Fotis Konstantinou, Nikolaos Katsikogiannis, Konstantinos Zarogoulidis, Ilias Karapantzos, Chrysanthi Karapantzou, Xiaping Shen, Isaak Kesisoglou, Konstantinos Sapalidis
Background: Due to the severity of the primary disease in patients with lung cancer, quality of life (QoL) is often overlooked. Factors that form QoL should be taken in consideration when planning the appropriate treatment and determining therapy targets, because of the increasing frequency of bone metastasis leading to high levels of pain. Purpose of this study is to assess quality of life in patients with lung cancer, before and after treatment combined with zoledronic acid. Methods and materials: QoL was assessed in 80 patients (49 males-31 females), of which 45 developed bone metastasis...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29787868/individualized-tractography-based-parcellation-of-the-globus-pallidus-pars-interna-using-7t-mri-in-movement-disorder-patients-prior-to-dbs-surgery
#5
Rémi Patriat, Scott E Cooper, Yuval Duchin, Jacob Niederer, Christophe Lenglet, Joshua Aman, Michael C Park, Jerrold L Vitek, Noam Harel
The success of deep brain stimulation (DBS) surgeries for the treatment of movement disorders relies on the accurate placement of an electrode within the motor portion of subcortical brain targets. However, the high number of electrodes requiring relocation indicates that today's methods do not ensure sufficient accuracy for all patients. Here, with the goal of aiding DBS targeting, we use 7 Tesla (T) MRI data to identify the functional territories and parcellate the globus pallidus pars interna (GPi) into motor, associative and limbic regions in individual subjects...
May 19, 2018: NeuroImage
https://www.readbyqxmd.com/read/29784838/in-vivo-and-in-vitro-effects-of-a-clpp-activating-antibiotic-against-vancomycin-resistant-enterococci
#6
Autumn Brown Gandt, Elizabeth C Griffith, Ida M Lister, Lisa L Billings, Angel Han, Rajendra Tangallapally, Ying Zhao, Aman P Singh, Richard E Lee, Michael D LaFleur
Antibiotics with novel bactericidal mechanisms of action are urgently needed. The antibiotic acyldepsipeptide 4 (ADEP4) activates the ClpP protease and causes cells to self-digest. The effects of ADEP4 and ClpP activation have not been sufficiently characterized for the enterococci, which are important pathogens known for high levels of acquired and intrinsic antibiotic resistance. In the present study, ADEP4 was found to be potently active against both Enterococcus faecalis and Enterococcus faecium with an MIC90 of 0...
May 21, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29770776/in-situ-transmission-electron-microscopy-of-transistor-operation-and-failure
#7
Baoming Wang, M Zahabul Islam, M Aman Haque, Kelson Chabak, Michael Snure, Eric Heller, Nicholas Robert Glavin
Microscopy is typically used as a post-mortem analytical tool in performance and reliability studies on nanoscale materials and devices. In this study, we demonstrate real-time microscopy of operation and failure of AlGaN/GaN high electron mobility transistors inside the transmission electron microscope (TEM). Loading till failure was performed on the electron transparent transistors to visualize the failure mechanisms caused by self heating. At lower drain voltages, thermo-mechanical stresses induce irreversible microstructural deformation, mostly along the AlGaN/GaN interface, to initiate the damage process...
May 17, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29769244/a-cs1-nkg2d-bispecific-antibody-collectively-activates-cytolytic-immune-cells-against-multiple-myeloma
#8
Wing Keung Chan, Siwen Kang, Youssef Youssef, Erin N Glankler, Emma R Barrett, Alex M Carter, Elshafa H Ahmed, Aman Prasad, Luxi Chen, Jianying Zhang, Don M Benson, Michael A Caligiuri, Jianhua Yu
Multiple myeloma (MM) is an incurable hematological malignancy of plasma cells with an estimated 30,000 new cases diagnosed each year in the United States, signifying the need for new therapeutic approaches. We hypothesized that targeting MM using a bispecific antibody (biAb) to simultaneously engage both innate and adaptive cytolytic immune cells could present potent antitumor activity. We engineered a biAb by fusing an anti-CS1 single chain variable fragment (scFv) and an anti-NKG2D scFv (CS1-NKG2D biAb)...
May 16, 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29694241/a-1-5-year-follow-up-of-parent-training-and-atomoxetine-for-attention-deficit-hyperactivity-disorder-symptoms-and-noncompliant-disruptive-behavior-in-autism
#9
L Eugene Arnold, Nicole Ober, Michael G Aman, Benjamin Handen, Tristram Smith, Xueliang Pan, Susan L Hyman, Jill Hollway, Luc Lecavalier, Kristin Page, Robert Rice
OBJECTIVE: To examine status of children with autism spectrum disorder (ASD) 10 months after a 34-week clinical trial of atomoxetine (ATX) and parent training (PT). METHODS: In a 2 × 2 design, 128 children with ASD and attention-deficit/hyperactivity disorder (ADHD) were randomly assigned ATX, PT+placebo, PT+ATX, or placebo alone. PT was weekly for 10 weeks, and then monthly. ATX/placebo was titrated over 6 weeks [≤1.8 mg/kg/d], and then maintained until week 10...
June 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29620914/effects-of-metformin-on-spatial-and-verbal-memory-in-children-with-asd-and-overweight-associated-with-atypical-antipsychotic-use
#10
Michael G Aman, Jill A Hollway, Jeremy Veenstra-VanderWeele, Benjamin L Handen, Kevin B Sanders, James Chan, Eric Macklin, L Eugene Arnold, Taylor Wong, Cassandra Newsom, Rianne Hastie Adams, Sarah Marler, Naomi Peleg, Evdokia A Anagnostou
OBJECTIVES: Studies in humans and rodents suggest that metformin, a medicine typically used to treat type 2 diabetes, may have beneficial effects on memory. We sought to determine whether metformin improved spatial or verbal memory in children with autism spectrum disorder (ASD) and overweight associated with atypical antipsychotic use. METHODS: We studied the effects of metformin (Riomet® ) concentrate on spatial and verbal memory in 51 youth with ASD, ages 6 through 17 years, who were taking atypical antipsychotic medications, had gained significant weight, and were enrolled in a trial of metformin for weight management...
May 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29611206/new-insights-into-the-cellular-mechanisms-of-plant-growth-at-elevated-atmospheric-carbon-dioxide
#11
REVIEW
Dananjali Gamage, Michael Thompson, Mark Sutherland, Naoki Hirotsu, Amane Makino, Saman Seneweera
Rising atmospheric carbon dioxide concentration ([CO2 ]) significantly influences plant growth, development and biomass. Increased photosynthesis rate, together with lower stomatal conductance, have been identified as the key factors that stimulate plant growth at elevated [CO2 ] (e[CO2 ]). However, variations in photosynthesis and stomatal conductance alone cannot fully explain the dynamic changes in plant growth. Stimulation of photosynthesis at e[CO2 ] is always associated with post-photosynthetic secondary metabolic processes that include carbon and nitrogen metabolism, cell cycle functions and hormonal regulation...
April 2, 2018: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29600785/utility-of-the-electrocardiogram-in-mapping-of-atrial-tachycardia-post-atrial-fibrillation-ablation-back-to-the-basics
#12
EDITORIAL
Michael Ghannam, Aman Chugh
No abstract text is available yet for this article.
January 2018: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29581792/inhaled-immunotherapy-administration-for-lung-cancer-efficient-certainly-possible
#13
Konstantinos Sapalidis, Paul Zarogoulidis, Haidong Huang, Chong Bai, Yuting Wen, Li Wang, Konstantina Boniou, Ilias Karapantzos, Chrysanthi Karapantzou, Michael Karanikas, Vasilis Thomaidis, Christoforos Kosmidis, Chrysanthi Sardeli, Naim Benhassen, Yan-Gao Man, Maria C Florou, Stylianos Mantalovas, Stella Laskou, Dimitris Giannakidis, Charilaos Koulouris, Aikaterini Amaniti, Isaak Kesisoglou, Wolfgang Hohenforst-Schmidt
Lung cancer is still diagnosed at a late stage in most lung cancer patients. Regarding Non-small Cell lung cancer there are novel therapies such as; tyrosine kinase inhibitors and immunotherapy. Currently we have two immunotherapies that can be used either as first-line treatment or second line treatment; pembrolizumab and nivolumab. A third one is being investigated as a combination of immunotherapy; ipilimumab. Aerosol treatment has been investigated for many diseases not only for the lung, but also for systematic diseases...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29581760/a-new-and-safe-mode-of-ventilation-for-interventional-pulmonary-medicine-the-ease-of-nasal-superimposed-high-frequency-jet-ventilation
#14
Wolfgang Hohenforst-Schmidt, Paul Zarogoulidis, Haidong Huang, Yan-Gao Man, Stella Laskou, Charilaos Koulouris, Dimitris Giannakidis, Stylianos Mantalobas, Maria C Florou, Aikaterini Amaniti, Michael Steinheimer, Anil Sinha, Lutz Freitag, J Francis Turner, Robert Browning, Thomas Vogl, Andrei Roman, Naim Benhassen, Isaak Kesisoglou, Konstantinos Sapalidis
We use pulmonary interventional procedures for the diagnosis of pulmonary diseases either for benign or malignant lesions. Flexible bronchoscopy with or without radial endobronchial ultrasound, convex-probe endobronchial ultrasound and electromagnetic navigation are procedures performed in centers with experience in diagnostic pulmonary medicine. The method of sedation and ventilation is very important in order to avoid or handle with success complications. Proper respiration during pulmonary (or other interventional) procedures is a key factor...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29502686/big-data-progress-or-a-big-headache
#15
EDITORIAL
Aman Dhawan, Jefferson C Brand, Michael J Rossi, James H Lubowitz
Large administrative database, or "big data" research studies can include an immense number of patients. Strengths of research based on big data include generalizability resulting from diverse patients, diverse providers, and diverse clinical settings. Limitations of research based on large administrative databases may include indeterminate quality and obscure purpose of data entry, lack of information regarding confounding variables, and suboptimal clinical outcome measures. Thus, research conclusions based on big data must be scrutinized in a discerning and critical manner...
March 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29485877/gas-hydrate-formation-probability-distributions-the-effect-of-shear-and-comparisons-with-nucleation-theory
#16
Eric F May, Vincent W Lim, Peter J Metaxas, Jianwei Du, Paul L Stanwix, Darren Rowland, Michael L Johns, Gert Haandrikman, Daniel Crosby, Zachary M Aman
Gas hydrate formation is a stochastic phenomenon of considerable significance for any risk-based approach to flow assurance in the oil and gas industry. In principle, well-established results from nucleation theory offer the prospect of predictive models for hydrate formation probability in industrial production systems. In practice, however, heuristics are relied on when estimating formation risk for a given flowline subcooling or when quantifying kinetic hydrate inhibitor (KHI) performance. Here, we present statistically significant measurements of formation probability distributions for natural gas hydrate systems under shear, which are quantitatively compared with theoretical predictions...
March 13, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29430408/using-bronchoscopy-to-detect-acquired-tracheoesophageal-fistula-in-mechanically-ventilated-patients
#17
Michael S Green, Johann J Mathew, Lia J Michos, Parmis Green, Mansoor M Aman
Introduction: An acquired Tracheoesophageal fistula (TEF) is commonly caused by a malignancy or trauma, with pulmonary infection or aspiration being the presenting symptom. However, in the critical care setting the presentation can be subtle and may present with difficult ventilation. High endotracheal tube cuff pressures can lead to tracheal erosions and thus increasing the chances for developing a TEF. Prolonged intubation in the presence of other risk factors like poor general state of health, episodic hypotension, nasogastric tubes, and repeated intubations can increase the likelihood of developing an acquired TEF...
August 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/29400810/innovative-scheme-for-high-repetition-rate-imaging-of-cn-radical
#18
Aman Satija, Morgan D Ruesch, Michael S Powell, Steven F Son, Robert P Lucht
We have employed, to the best of our knowledge, a novel excitation scheme to perform the first high-repetition-rate planar laser-induced fluorescence (PLIF) measurements of a CN radical in combustion. The third harmonic of a Nd:YVO4 laser at 355 nm due to its relatively large linewidth overlaps with several R branch transitions in a CN ground electronic state. Therefore, the 355 nm beam was employed to directly excite the CN transitions with good efficiency. The CN measurements were performed in premixed CH4 -N2 O flames with varying equivalence ratios...
February 1, 2018: Optics Letters
https://www.readbyqxmd.com/read/29173736/clinical-implications-from-the-treatment-of-severe-childhood-aggression-tosca-study-a-re-analysis-and-integration-of-findings
#19
RANDOMIZED CONTROLLED TRIAL
Justin A Barterian, L Eugene Arnold, Nicole V Brown, Cristan A Farmer, Craig Williams, Robert L Findling, David J Kolko, Oscar G Bukstein, Brooke S G Molina, Lisa Townsend, Michael G Aman
OBJECTIVE: The Treatment of Severe Childhood Aggression (TOSCA) project examined augmentation of stimulant treatment and parent training (PT) with risperidone for severe physical aggression. This article summarizes the clinical implications; reanalyzes the data to examine the utility of 4 criteria for deciding to augment; and presents a treatment algorithm. METHOD: The newly analyzed 4 criteria for augmenting after 3 weeks of stimulant and PT treatment consisted of not meeting a Clinical Global Impressions-Improvement (CGI-I) score of 1 and a normal score (≤15) on the Nisonger Child Behavior Rating Form Disruptive-Total (D-Total); a CGI-I score of 1 or 2 plus 25% improvement in D-Total score; a D-Total score no higher than 15; and a CGI-Severity score of 3 (mild) or better...
December 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29118211/sensation-during-active-behaviors
#20
REVIEW
Laura Busse, Jessica A Cardin, M Eugenia Chiappe, Michael M Halassa, Matthew J McGinley, Takayuki Yamashita, Aman B Saleem
A substantial portion of our sensory experience happens during active behaviors such as walking around or paying attention. How do sensory systems work during such behaviors? Neural processing in sensory systems can be shaped by behavior in multiple ways ranging from a modulation of responsiveness or sharpening of tuning to a dynamic change of response properties or functional connectivity. Here, we review recent findings on the modulation of sensory processing during active behaviors in different systems: insect vision, rodent thalamus, and rodent sensory cortices...
November 8, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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