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https://www.readbyqxmd.com/read/29277249/fine-tuning-the-normal-tissue-objective-in-eclipse-for-lung-stereotactic-body-radiation-therapy
#1
James P Bell, Pretesh Patel, Kristin Higgins, Mark W McDonald, Justin Roper
The purpose of this study was to characterize the effects of the normal tissue objective (NTO) on lung stereotactic body radiation therapy (SBRT) dose distributions. The NTO is a spatially varying constraint used in Eclipse to limit dose to normal tissues by steepening the dose gradient. However, the multitude of potential NTO setting combinations challenges optimal NTO tuning. In the present study, a broad range of NTO settings are investigated for lung SBRT treatment planning with volumetric modulated arc therapy(VMAT)...
December 22, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29235988/optimal-transformations-leading-to-normal-distributions-of-positron-emission-tomography-standardized-uptake-values
#2
Matthew Scarpelli, Jens Eickhoff, Enrique Cuna, Scott Perlman, Robert Jeraj
The statistical analysis of positron emission tomography (PET) standardized uptake value (SUV) measurements is challenging due to the skewed nature of SUV distributions. This limits utilization of powerful parametric statistical models for analyzing SUV measurements. An ad-hoc approach, which is frequently used in practice, is to blindly use a log transformation, which may or may not result in normal SUV distributions. This study sought to identify optimal transformations leading to normally distributed PET SUVs extracted from tumors and assess the effects of therapy on the optimal transformations...
December 13, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29227151/evaluating-which-plan-quality-metrics-are-appropriate-for-use-in-lung-sbrt
#3
Ravindra Yaparpalvi, Madhur K Garg, Jin Shen, William R Bodner, Dinesh K Mynampati, Aleiya Gafar, Hsiang-Chi Kuo, Amar K Basavatia, Nitin Ohri, Linda X Hong, Shalom Kalnicki, Wolfgang A Tomé
OBJECTIVES: Several dose metrics in the categories - homogeneity, coverage, conformity and gradient have been proposed in literature for evaluating treatment plan quality. In this study, we applied these metrics to characterize and identify the plan quality metrics that would merit plan quality assessment in Lung SBRT dose distributions. METHODS: Treatment plans of 90 Lung SBRT patients, comprising 91 targets, treated in our institution were retrospectively reviewed...
December 11, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29225693/cytoreductive-prostate-radiotherapy-in-oligometastatic-prostate-cancer-a-single-centre-analysis-of-toxicity-and-clinical-outcome
#4
Giulia Riva, Giulia Marvaso, Matteo Augugliaro, Dario Zerini, Cristiana Fodor, Gennaro Musi, Ottavio De Cobelli, Roberto Orecchia, Barbara Alicja Jereczek-Fossa
Objectives: The current standard of care for patients with metastatic prostate cancer (mPCa) at diagnosis is androgen deprivation therapy (ADT) with or without anti-androgen and chemotherapy. The aim of this study was to define the role of a local radiotherapy (RT) treatment in the mPCa setting. Methods: We retrospectively reviewed data of patients with PCa and bone oligometastases at diagnosis treated in our institution with ADT followed by cytoreductive prostate-RT with or without RT on metastases...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/29217331/dosimetric-impact-of-translational-and-rotational-setup-errors-for-spine-stereotactic-body-radiotherapy-a-phantom-study
#5
Makoto Sasaki, Mitsuhiro Nakamura, Nobutaka Mukumoto, Manabu Nakata, Masahiro Hiraoka
This study aimed to investigate experimentally the effect of translational and rotational setup errors on 3-dimensional dose distributions by using the gamma index and dose volumetric indices for spine stereotactic body radiotherapy. Treatment plans were designed in accordance with the Radiation Therapy Oncology Group (RTOG) 0631 protocol. Measurements were taken using a Delta4 phantom (ScandiDos, Uppsala, Sweden). Setup errors were generated using the HexaMotion 6D moving platform (ScandiDos). Dose distributions in the presence of setup errors were evaluated, according to the γ passing rate with the 3% and 2 mm criteria (γ3%/2 mm) and dose volumetric indices (D90 for the target volume and D2 for the spinal cord), using the Delta4 device (ScandiDos)...
December 4, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29204528/serum-testosterone-changes-in-patients-treated-with-radiation-therapy-alone-for-prostate-cancer-on-nrg-oncology-rtog-9408
#6
R Charles Nichols, Chen Hu, Jean-Paul Bahary, Kenneth L Zeitzer, Luis Souhami, Mark H Leibenhaut, Marvin Rotman, Elizabeth M Gore, Alexander G Balogh, David McGowan, Jeff Michalski, Adam Raben, Shari Rudoler, Christopher U Jones, Howard Sandler
Objectives: We reviewed testosterone changes for patients who were treated with radiation therapy (RT) alone on NRG oncology RTOG 9408. Methods and materials: Patients (T1b-T2b, prostate-specific antigen <20 ng/mL) were randomized between RT alone and RT plus 4 months of androgen ablation. Serum testosterone (ST) levels were investigated at enrollment, RT completion, and the first follow-up 3 months after RT. The Wilcoxon signed rank test was used to compare pre- and post-treatment ST levels in patients who were randomized to the RT-alone arm...
October 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29179751/prospective-phase-ii-study-evaluating-postoperative-radiotherapy-of-cervical-and-endometrial-cancer-patients-using-protons-the-aprove-trial
#7
N Arians, K Lindel, J Krisam, K Herfarth, D Krug, S Akbaba, J Oelmann-Avendano, J Debus
BACKGROUND: The prognosis for patients with cervical or endometrial cancer has improved over the last decades. Thus, reducing therapy-related toxicity and impact on quality of life have become more and more important. With the development of new radiotherapy techniques like IMRT (Intensity-modulated radiotherapy) the incidence of acute and chronic toxicities has already been reduced. Nevertheless, rates of complications requiring medical treatment range from 0.7-8% according to literature...
November 28, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29176539/efficacy-and-safety-of-chemotherapy-combined-with-stereotactic-radiotherapy-in-the-treatment-of-nasopharyngeal-carcinoma
#8
Guo-Ping Shan, Bing-Bing Wang, Peng Zheng, Feng-Lei Du, Yi-Wei Yang
BACKGROUND The aim of this study was to investigate the efficacy and safety of chemotherapy (CT) combined with stereotactic radiotherapy (SRT) in the treatment of nasopharyngeal carcinoma (NPC). MATERIAL AND METHODS A total of 329 NPC patients without any previous treatment were included in this study between January 2009 and November 2013. These patients were divided into three groups: CT group (n=114), SRT group (n=109), and CT + SRT group (n=106). Contrast-enhanced nasopharyngeal computed tomography (CT)/magnetic resonance (MR) scan was performed on the third month after treatment...
November 26, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29171166/outcomes-of-asian-patients-with-localized-prostate-cancer-treated-with-combined-intensity-modulated-radiation-therapy-imrt-and-high-dose-rate-hdr-brachytherapy-a-single-institution-experience
#9
Ivy Wei Shan Ng, Jeremy Chee Seong Tey, Yu Yang Soon, Michelle Shu Fen Tseng, Desiree Chen, Keith Hsiu Chin Lim
AIM: External beam radiotherapy (EBRT) followed by high dose rate (HDR) brachytherapy boost has demonstrated minimal toxicities and improved disease control rate compared with EBRT alone in observational and randomized studies with predominantly Caucasian patients. This study aims to report the outcomes of patients treated with this approach in our predominantly Asian population. METHODS: Medical records for patients with localized prostate cancer who received combined EBRT delivered via intensity modulated radiotherapy (IMRT) technique followed by HDR brachytherapy boost were retrospectively reviewed...
November 23, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29159777/prognostic-factors-for-survival-in-adult-patients-with-recurrent-glioblastoma-a-decision-tree-based-model
#10
Etienne Audureau, Anaïs Chivet, Renata Ursu, Robert Corns, Philippe Metellus, Georges Noel, Sonia Zouaoui, Jacques Guyotat, Pierre-Jean Le Reste, Thierry Faillot, Fabien Litre, Nicolas Desse, Antoine Petit, Evelyne Emery, Emmanuelle Lechapt-Zalcman, Johann Peltier, Julien Duntze, Edouard Dezamis, Jimmy Voirin, Philippe Menei, François Caire, Phong Dam Hieu, Jean-Luc Barat, Olivier Langlois, Jean-Rodolphe Vignes, Pascale Fabbro-Peray, Adeline Riondel, Elodie Sorbets, Marc Zanello, Alexandre Roux, Antoine Carpentier, Luc Bauchet, Johan Pallud
We assessed prognostic factors in relation to OS from progression in recurrent glioblastomas. Retrospective multicentric study enrolling 407 (training set) and 370 (external validation set) adult patients with a recurrent supratentorial glioblastoma treated by surgical resection and standard combined chemoradiotherapy as first-line treatment. Four complementary multivariate prognostic models were evaluated: Cox proportional hazards regression modeling, single-tree recursive partitioning, random survival forest, conditional random forest...
November 20, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29151959/survival-and-toxicities-of-imrt-based-on-the-rtog-protocols-in-patients-with-nasopharyngeal-carcinoma-from-the-endemic-regions-of-china
#11
Shao-Bo Liang, Yan Wang, Xue-Feng Hu, Sha-Sha He, Xing-Li Yang, Li-Zhi Liu, Chun-Yan Cui, Yong Chen, Li-Wu Fu
Background: This study evaluated the survival outcomes and toxicities of intensity-modulated radiation therapy (IMRT) based on the RTOG 0225/0615 RT protocols in patients with nasopharyngeal carcinoma (NPC) from a region of China where this tumor type is endemic. Methods: A total of 455 patients with non-metastatic, histologically-confirmed NPC were retrospectively reviewed. All patients were treated by IMRT using the RTOG 0225/0615 RT protocols; 91.1% (288/316) of patients with stage III-IVb NPC received concurrent chemotherapy +/- induction chemotherapy or adjuvant chemotherapy...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29126203/a-randomized-phase-ii-study-of-everolimus-in-combination-with-chemoradiation-in-newly-diagnosed-glioblastoma-results-of-nrg-oncology-rtog-0913
#12
Prakash Chinnaiyan, Minhee Won, Patrick Y Wen, Amyn M Rojiani, Maria Werner-Wasik, Helen A Shih, Lynn S Ashby, Hsiang-Hsuan Michael Yu, Volker W Stieber, Shawn C Malone, John B Fiveash, Nimish A Mohile, Manmeet S Ahluwalia, Merideth M Wendland, Philip J Stella, Andrew Y Kee, Minesh P Mehta
Background: This Phase II study was designed to determine the efficacy of the mTOR inhibitor everolimus administered daily with conventional radiation therapy and chemotherapy in patients with newly diagnosed glioblastoma. Methods: Patients were randomized to radiation therapy with concurrent and adjuvant temozolomide with or without daily everolimus (10 mg). The primary endpoint was progression-free survival (PFS) and the secondary endpoints were overall survival (OS) and treatment-related toxicities...
November 6, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/29123013/68ga-psma-pet-ct-mapping-of-prostate-cancer-biochemical-recurrence-following-radical-prostatectomy-in-270-patients-with-psa-1-0ng-ml-impact-on-salvage-radiotherapy-planning
#13
Jérémie Calais, Johannes Czernin, Minsong Cao, Amar U Kishan, John V Hegde, Narek Shaverdian, Kiri A Sandler, Fang-I Chu, Chris R King, Michael L Steinberg, Isabel Rausher, Nina-Sophie Schmidt-Hegemann, Thorsten Poeppel, Philipp Hetkamp, Francesco Ceci, Ken Herrmann, Wolfgang P Fendler, Matthias Eiber, Nicholas G Nickols
Background: Target volume delineations for prostate cancer (PCa) salvage radiotherapy (SRT) after radical prostatectomy are usually drawn in the absence of visibly recurrent disease. Gallium-68 Prostate Specific Membrane Antigen Positron Emission Tomography/Computed Tomography (68Ga-PSMA-11 PET/CT) detects recurrent PCa with sensitivity superior to standard of care imaging at serum prostate specific antigen (PSA) values low enough to impact target volume delineations for routine SRT. OBJECTIVE: To i) map the recurrence pattern of PCa early biochemical recurrence (BCR) after radical prostatectomy with 68Ga-PSMA-11 PET/CT in patients with serum PSA levels <1 ng/ml, ii) determine how often consensus clinical target volumes (CTV) based on the Radiation Therapy Oncology Group (RTOG) guidelines cover 68Ga-PSMA-11 PET/CT-defined disease, and iii) assess the potential impact of 68Ga-PSMA-11 PET/CT on SRT...
November 9, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29117865/correction-to-improved-plan-quality-with-automated-radiotherapy-planning-for-whole-brain-with-hippocampus-sparing-a-comparison-to-the-rtog-0933-trial
#14
J Krayenbuehl, M Di Martino, M Guckenberger, N Andratschke
In the original publication [1] figure legends 2 and 4 have been swapped. The original article was updated to rectify this error.
November 8, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29108254/the-impacts-of-genetic-polymorphisms-in-genes-of-base-excision-repair-pathway-on-the-efficacy-and-acute-toxicities-of-chemo-radiotherapy-in-patients-with-nasopharyngeal-carcinoma
#15
Jing Wang, Chengxian Guo, Xiaochang Gong, Fan Ao, Yuling Huang, Lihua Huang, Yiqiang Tang, Chunling Jiang, Xiaoxue Xie, Qing Dong, Min Huang, Jingao Li
Purpose: To explore whether polymorphisms in base excision repair (BER) pathway genes are predictors of (chemo)radiotherapy outcome in patients with nasopharyngeal carcinoma (NPC). Methods: We genotyped five potentially functional single nucleotide polymorphisms (SNPs) of three genes in the BER pathway in 174 NPC patients who were treated with (chemo)radiotherapy. Sequenom MassArray was used for SNPs analysis. The efficacy at the end of radiotherapy and at 3 months after radiotherapy was evaluated by Response Evaluation Criteria in Solid Tumors (RECIST)...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29103755/a-failure-type-specific-risk-prediction-tool-for-selection-of-head-and-neck-cancer-patients-for-experimental-treatments
#16
Katrin Håkansson, Jacob H Rasmussen, Gregers B Rasmussen, Jeppe Friborg, Thomas A Gerds, Barbara Malene Fischer, Flemming L Andersen, Søren M Bentzen, Lena Specht, Ivan R Vogelius
OBJECTIVES: The objective of this work was to develop a tool for decision support, providing simultaneous predictions of the risk of loco-regional failure (LRF) and distant metastasis (DM) after definitive treatment for head-and-neck squamous cell carcinoma (HNSCC). MATERIALS AND METHODS: Retrospective data for 560HNSCC patients were used to generate a multi-endpoint model, combining three cause-specific Cox models (LRF, DM and death with no evidence of disease (death NED))...
November 2017: Oral Oncology
https://www.readbyqxmd.com/read/29102648/investigating-the-effect-of-reirradiation-or-systemic-therapy-in-patients-with-glioblastoma-after-tumor-progression-a-secondary-analysis-of-nrg-oncology-radiation-therapy-oncology-group-trial-0525
#17
Wenyin Shi, Molly Scannell Bryan, Mark R Gilbert, Minesh P Mehta, Deborah T Blumenthal, Paul D Brown, Egils Valeinis, Kirsten Hopkins, Luis Souhami, David W Andrews, Tzahala Tzuk-Shina, Steve P Howard, Emad F Youssef, Nathalie Lessard, James J Dignam, Maria Werner-Wasik
PURPOSE: To determine the impact on overall survival with different salvage therapies, including no treatment, reirradiation, systemic therapy, or radiation and systemic therapy, in participants of a phase 3 clinical trial evaluating dose-dense versus standard-dose temozolomide for patients with newly diagnosed glioblastoma. METHODS AND MATERIALS: This analysis of patients from Trial RTOG 0525 investigated the effect of reirradiation or systemic treatment after tumor progression...
September 4, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29102264/radiation-toxicity-in-patients-with-collagen-vascular-disease-and-intrathoracic-malignancy-treated-with-modern-radiation-techniques
#18
Kevin Diao, Yu-Hui Chen, Paul J Catalano, Stephanie Lee, Nastaran Milani, Joseph H Killoran, Elizabeth H Baldini, Aileen B Chen, David E Kozono, Raymond H Mak
BACKGROUND AND PURPOSE: There is concern that patients with collagen vascular disease (CVD) are at higher risk of developing radiation toxicity. We analyzed radiation toxicities in patients with intrathoracic malignancy and CVD treated using modern radiotherapy. MATERIALS AND METHODS: This single-institution retrospective study included 31 patients with CVD and 825 patients without CVD treated from 1998 to 2014. Radiation esophagitis (RE) and radiation pneumonitis (RP) were scored by RTOG scales...
October 25, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29096619/incorporating-18-fdg-pet-defined-pelvic-active-bone-marrow-in-the-automatic-treatment-planning-process-of-anal-cancer-patients-undergoing-chemo-radiation
#19
Pierfrancesco Franco, Christian Fiandra, Francesca Arcadipane, Elisabetta Trino, Francesca Romana Giglioli, Riccardo Ragona, Umberto Ricardi
BACKGROUND: To investigate whether the incorporation of (18)FDG-PET into the automatic treatment planning process may be able to decrease the dose to active bone marrow (BM) for locally advanced anal cancer patients undergoing concurrent chemo-radiation (CHT-RT). METHODS: Ten patients with locally advanced anal cancer were selected. Bone marrow within the pelvis was outlined as the whole outer contour of pelvic bones or employing (18)FDG-PET to identify active BM within osseous structures...
November 2, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29072852/the-effect-of-mepitel-film-on-acute-radiation-induced-skin-reactions-in-head-and-neck-cancer-patients-a-feasibility-study
#20
Hayley Wooding, Jing Yan, Ling Yuan, Te-Yu Chyou, Shanbao Gao, Iain Ward, Patries M Herst
OBJECTIVE: Mepitel Film significantly decreases acute radiation-induced skin reactions in breast cancer patients. Here we investigated the feasibility of using Mepitel Film in head and neck cancer patients (ACTRN12614000932662). METHODS: Out of a total of 36 head and neck cancer patients from New Zealand (NZ) (n=24) and China (n=12) recruited between June 2015 and December 2016, 33 patients complied with protocol. Of these, 11 NZ patients followed a management protocol; 11 NZ patients and 11 Chinese patients followed a prophylactic protocol...
October 26, 2017: British Journal of Radiology
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