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https://www.readbyqxmd.com/read/28930259/sandalwood-oil-and-turmeric-based-cream-prevents-ionizing-radiation-induced-dermatitis-in-breast-cancer-patients-clinical-study
#1
Suresh Rao, Sanath Kumar Hegde, Manjeshwar Poonam Baliga-Rao, Jyothi Lobo, Princy Louis Palatty, Thomas George, Manjeshwar Shrinath Baliga
Background: The primary objective of this study was to ascertain the benefit of Vicco turmeric Ayurvedic cream (VTC; Vicco Laboratories, Mumbai, India) sandalwood oil and turmeric-based cream in preventing radiodermatitis in women undergoing curative radiotherapy for their breast cancer. Methods and Materials: The study was an investigator-blinded randomized study with Johnsons Baby Oil (JBO; Johnson & Johnson Ltd., Baddi, India) as a comparator, administered daily from the start of radiation therapy for 5 weeks in women receiving breast radiation therapy, 50 Gy in 2 Gy fractions daily for 5 weeks...
June 24, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28930258/an-aloe-vera-based-cosmeceutical-cream-delays-and-mitigates-ionizing-radiation-induced-dermatitis-in-head-and-neck-cancer-patients-undergoing-curative-radiotherapy-a-clinical-study
#2
Suresh Rao, Sanath Kumar Hegde, Manjeshwar Poonam Baliga-Rao, Princy Louis Palatty, Thomas George, Manjeshwar Shrinath Baliga
Background: This study was planned to evaluate the efficacy of topical application of an Aloe vera-based cream (AVC) for the prevention of ionizing radiation (X ray)-induced dermatitis in head and neck cancer patients requiring therapeutic radiation treatment (>62 Gy). Methods: From July 2012 to December 2012, a total of 60 head and neck cancer patients requiring curative radiotherapy (RT) of more than 66 Gy were prospectively enrolled and treated with AVC or a comparator Johnson's Baby Oil (JBO). Acute skin reaction was monitored and classified according to the Radiation Therapy Oncology Group (RTOG) four-point rating scale on a weekly basis...
June 24, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28929310/postoperative-radiotherapy-for-prostate-cancer-morbidity-of-local-only-or-local-plus-pelvic-radiotherapy
#3
Cora Waldstein, Wolfgang Dörr, Richard Pötter, Joachim Widder, Gregor Goldner
PURPOSE: The aim of this work was to characterise actuarial incidence and prevalence of early and late side effects of local versus pelvic three-dimensional conformal postoperative radiotherapy for prostate cancer. MATERIALS AND METHODS: Based on a risk-adapted protocol, 575 patients received either local (n = 447) or local-plus-pelvic (n = 128) radiotherapy. Gastrointestinal (GI) and genitourinary (GU) side effects (≥grade 2 RTOG/EORTC criteria) were prospectively assessed...
September 19, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28878156/honey-mitigates-radiation-induced-oral-mucositis-in-head-and-neck-cancer-patients-without-affecting-the-tumor-response
#4
Suresh Rao, Sanath K Hegde, Pratima Rao, Chetana Dinkar, Karadka R Thilakchand, Thomas George, Manjeshwar P Baliga-Rao, Princy L Palatty, Manjeshwar S Baliga
Radiation-induced mucositis is a dose-limiting factor in the effective treatment of head and neck (H & N) cancers. The objective of this study was to understand the efficacy of honey in mitigating radiation-induced mucositis and whether it would interfere with tumor control. This was a single-blinded, randomized, controlled study and was carried out in patients with H & N cancer requiring curative radiotherapy (>62 Gy (Gray)). The patients meeting the inclusion criteria were randomly assigned to receive either honey ( n = 25) or povidone-iodine (active comparator) ( n = 25) during radiotherapy...
September 6, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28870525/rectal-balloon-use-limits-vaginal-displacement-rectal-dose-and-rectal-toxicity-in-patients-receiving-imrt-for-postoperative-gynecological-malignancies
#5
Cheng-Chia Wu, Yen-Ruh Wuu, Theodore Yanagihara, Ashish Jani, Eric P Xanthopoulos, Akhil Tiwari, Jason D Wright, William M Burke, June Y Hou, Ana I Tergas, Israel Deutsch
Pelvic radiotherapy for gynecologic malignancies traditionally used a 4-field box technique. Later trials have shown the feasibility of using intensity-modulated radiotherapy (IMRT) instead. But vaginal movement between fractions is concerning when using IMRT due to greater conformality of the isodose curves to the target and the resulting possibility of missing the target while the vagina is displaced. In this study, we showed that the use of a rectal balloon during treatment can decrease vaginal displacement, limit rectal dose, and limit acute and late toxicities...
September 1, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28867544/standardization-of-radiation-therapy-dose-for-locally-advanced-non-small-cell-lung-cancer-through-changes-to-a-lung-cancer-clinical-pathway-in-a-large-integrated-comprehensive-cancer-center-network
#6
Pooja Karukonda, Brian J Gebhardt, Zachary D Horne, Dwight E Heron, Sushil Beriwal
PURPOSE: The results of Radiation Therapy Oncology Group (RTOG) 0617, which randomized patients with stages IIIA/IIIB non-small cell lung cancer (NSCLC) to definitive chemoradiation therapy to 60 Gy versus 74 Gy, demonstrated a detrimental survival impact with high-dose radiation therapy. We evaluated the impact of changes to a provider-driven clinical pathway (CP) guiding management of NSCLC on practice throughout our cancer center network. METHODS AND MATERIALS: In 2001, we implemented a CP for management of stage IIIA/IIIB NSCLC with definitive chemoradiation therapy...
July 8, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28856848/image-guided-imrt-with-simultaneous-integrated-boost-as-per-rtog-0529-for-the-treatment-of-anal-cancer
#7
Francesca Arcadipane, Pierfrancesco Franco, Manuela Ceccarelli, Gabriella Furfaro, Nadia Rondi, Elisabetta Trino, Stefania Martini, Giuseppe Carlo Iorio, Massimiliano Mistrangelo, Paola Cassoni, Patrizia Racca, Mario Morino, Umberto Ricardi
AIM: To report on clinical outcomes of simultaneous integrated boost intensity-modulated radiation therapy (IMRT) and concurrent chemotherapy as per Radiation Therapy Oncology Group (RTOG) 0529 protocol in anal cancer patients. METHODS: Clinical stage T1-T4 N0-N3 anal cancer patients were submitted to concomitant chemoradiation. Patients with cT2N0 disease were prescribed 50.4 Gy/28 fractions to the gross tumor planning target volume (PTV) and 42 Gy/28 fractions to the elective nodal PTV...
August 30, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28851315/propensity-score-matching-analysis-of-a-phase-ii-study-on-simultaneous-modulated-accelerated-radiation-therapy-using-helical-tomotherapy-for-nasopharyngeal-carcinomas
#8
Lei Du, Xin-Xin Zhang, Lin-Chun Feng, Bao-Lin Qu, Jing Chen, Jun Yang, Hai-Xia Liu, Shou-Ping Xu, Chuan-Bin Xie, Lin Ma
BACKGROUND: Using propensity score matching method (PSM) to evaluate the feasibility and clinical outcomes of simultaneous modulated accelerated radiation therapy (SMART) using helical tomotherapy (HT) in patients with nasopharyngeal carcinoma (NPC). METHODS: Between August 2007 and January 2016, 381 newly diagnosed NPC patients using HT were enrolled in pre-PSM cohort, including 161 cases in a prospective phase II study (P67.5 study, with a prescription dose of 67...
August 29, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28837234/a-precision-3d-conformal-treatment-technique-in-rats-application-to-whole-brain-radiotherapy-with-hippocampal-avoidance
#9
Suk W Yoon, Christina K Cramer, Devin A Miles, Michael H Reinsvold, Kyeung M Joo, David G Kirsch, Mark Oldham
PURPOSE: To develop and validate 3D conformal hippocampal sparing whole-brain radiation therapy (HA-WBRT) for Wistar rats utilizing precision 3D printed immobilization and micro-blocks. This technique paves the way for future pre-clinical studies investigating brain treatments that reduce neurotoxicity. METHODS AND MATERIALS: A novel pre-clinical treatment planning and delivery process was developed to enable precision 3D conformal treatment and hippocampal avoidance capability for the Xrad 225cx small animal irradiator...
August 24, 2017: Medical Physics
https://www.readbyqxmd.com/read/28836106/the-impact-of-adjuvant-therapy-for-patients-with-high-risk-diffuse-who-grade-ii-glioma
#10
Ryan S Youland, Cole R Kreofsky, David A Schomas, Paul D Brown, Jan C Buckner, Nadia N Laack
Despite recent randomized, prospective evidence supporting use of RT and chemotherapy (CRT) for high-risk low-grade gliomas (LGG), many patients have historically received RT alone, chemotherapy alone or observation postoperatively. The purpose of this study is to evaluate outcomes for historical treatments in comparison to CRT for high-risk diffuse WHO grade II glioma patients. Records from 309 adults with WHO grade II glioma (1997-2008) eligible for RTOG 9802 (incomplete resection/biopsy or age ≥40 years) were retrospectively reviewed...
August 23, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28830293/the-narlal2-dose-escalation-trial-dosimetric-implications-of-inter-fractional-changes-in-organs-at-risk
#11
Lone Hoffmann, Marianne Marquard Knap, Azza Ahmed Khalil, Christina Maria Lutz, Ditte Sloth Møller
BACKGROUND: Phase II trials suggested that survival rates for locally advanced lung cancer could be increased by radiotherapy dose escalation. However, results of the phase III RTOG 0617 trial illustrated an imminent risk of treatment-related death. This could be thwarted with strict constraints to organs at risk (OARs) and control of the delivered dose. This study investigates the impact of anatomical changes during radiotherapy on escalated dose distributions used in the Danish NARLAL2 dose escalation trial...
August 23, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28830202/radiological-distribution-of-brain-metastases-and-it-s-implication-for-the-hippocampus-avoidance-in-whole-brain-radiotherapy-approach
#12
Yi-Min Han, Gang Cai, Wei-Min Chai, Cheng Xu, Lu Cao, Dan Ou, Jia-Yi Chen, Youlia M Kirova
PURPOSE: Hippocampus avoidance in whole brain radiotherapy (HA-WBRT) offers the feasibility of less impaired cognitive function than conventional WBRT. The study aims to assess the radiological distribution of BMs with relation to the hippocampus and peri-hippocampus(PH) region as defined by the RTOG 0933 for better understanding of margin definition in HA-WBRT treatment planning. METHODS: Consecutive patients with diagnosis of BM from enhanced MRI between 03/2011 and 07/2016 were analyzed...
August 22, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28827937/hypofractionated-radiotherapy-for-palliation-in-locally-advanced-head-and-neck-cancer
#13
R K Spartacus, Rohitashwa Dana, Kartick Rastogi, Aseem Rai Bhatnagar, Dhiraj Daga, Kampra Gupta
CONTEXT: In India, a considerable proportion of patients with head and neck cancer present with locoregionally advanced disease. Symptom palliation becomes a major objective in these cases when they could not be considered for a curative approach. AIMS: The aim of this study is to assess the role of palliative radiotherapy for symptom control in patients with locally advanced head and neck cancer. SETTINGS AND DESIGN: This was a retrospective study...
July 2017: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/28822604/volumetric-modulated-arc-therapy-vmat-for-whole-brain-radiotherapy-not-only-for-hippocampal-sparing-but-also-for-reduction-of-dose-to-organs-at-risk
#14
Sumit Sood, Damodar Pokhrel, Christopher McClinton, Christopher Lominska, Rajeev Badkul, Hongyu Jiang, Fen Wang
A prospective clinical trial, Radiation Therapy Oncology Group (RTOG) 0933, has demonstrated that whole brain radiotherapy (WBRT) using conformal radiation delivery technique with hippocampal avoidance is associated with less memory complications. Further sparing of other organs at risk (OARs) including the scalp, ear canals, cochleae, and parotid glands could be associated with reductions in additional toxicities for patients treated with WBRT. We investigated the feasibility of WBRT using volumetric-modulated arc therapy (VMAT) to spare the hippocampi and the aforementioned OARs...
August 16, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28821277/the-feasibility-analysis-of-omission-of-elective-irradiation-to-level-ib-lymph-nodes-in-low-risk-nasopharyngeal-carcinoma-based-on-the-2013-updated-consensus-guideline-for-neck-nodal-levels
#15
Xiaomin Ou, Yibing Miao, Xiaoshen Wang, Jianhui Ding, Xiayun He, Chaosu Hu
BACKGROUND: Level IB metastasis is rare in nasopharyngeal carcinoma (NPC). The purpose of this study is to investigate the high-risk factors for level IB metastasis and evaluate the feasibility of omission of elective irradiation to level IB in the low-risk subgroups in NPC. METHODS: This retrospective study identified 532 patients with NPC treated by definitive radiation in our institution from 2009 to 2010. Level IB nodes were electively irradiated based on the physician's decision...
August 18, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28821268/hypo-fractionated-sbrt-for-localized-prostate-cancer-a-german-bi-center-single-treatment-group-feasibility-trial
#16
Ping Jiang, Katja Krockenberger, Reinhard Vonthein, Jane Tereszczuk, Arne Schreiber, Sebastian Liebau, Stefan Huttenlocher, Detlef Imhoff, Panagiotis Balermpas, Christian Keller, Kathrin Dellas, Rene Baumann, Claus Rödel, Guido Hildebrandt, Klaus-Peter Jünemann, Alex S Merseburger, Alan Katz, Andreas Ziegler, Oliver Blanck, Jürgen Dunst
BACKGROUND: For prostate cancer treatment, treatment options with minimal side effects are desired. External beam radiation therapy (EBRT) is non-invasive, standard of care and delivered in either conventional fractionation over 8 weeks or with moderate hypo-fractionation over about 5 weeks. Recent advances in radiotherapy technology have made extreme hypo-fractionated stereotactic body radiation therapy (SBRT) of prostate cancer feasible, which has not yet been introduced as a standard treatment method in Germany...
August 18, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28816165/incidence-and-predictors-of-pericardial-effusion-after-chemoradiation-therapy-for-locally-advanced-non-small-cell-lung-cancer
#17
RANDOMIZED CONTROLLED TRIAL
Matthew S Ning, Linglong Tang, Daniel R Gomez, Ting Xu, Yangkun Luo, Jinhai Huo, Elie Mouhayar, Zhongxing Liao
PURPOSE: Findings from Radiation Therapy Oncology Group (RTOG) 0617 suggested that collateral radiation to the heart may contribute to early death in patients receiving chemoradiation therapy for non-small cell lung cancer (NSCLC); however, reports of cardiac toxicity after thoracic radiation therapy (RT) remain limited. Because pericardial disease is the most common cardiac complication of thoracic RT, we investigated the incidence of and risk factors for pericardial effusion (PCE) in patients enrolled in a phase 2 prospective randomized study of intensity modulated RT versus proton therapy for locally advanced NSCLC...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28807748/dosimetric-analysis-and-preliminary-clinical-result-of-image-guided-brachytherapy-with-or-without-hybrid-technique-for-cervical-cancer-using-varisource-titanium-ring-applicator-with-siriraj-ring-cap
#18
Pittaya Dankulchai, Suphalerk Lohasammakul, Janjira Petsuksiri, Pitchayut Nakkrasae, Lalida Tuntipumiamorn, Chumpot Kakanaporn, Yaowalak Chansilpa
PURPOSE: Titanium ring cap applicator (VariSource) was applied in treating cervical cancer patients by using image-guided brachytherapy (IGBT). However, its sizes appeared to be relatively large for most of our patients. Thus, we have developed a specific applicator "Siriraj Ring Cap," which is slightly smaller and more suitable for our patients. This study was to evaluate effectiveness of this equipment. METHODS AND MATERIALS: Locally advanced cervical cancer patients were treated with external beam radiation therapy with or without concomitant chemotherapy...
August 11, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28805047/outcomes-of-post-prostatectomy-radiotherapy-at-a-regional-cancer-centre
#19
Luke Nicholls, Amber Winter, Ashley Harwood, Ashley Plank, Preeti Bagga, Winnie Wong, Eric Khoo
INTRODUCTION: To investigate the efficacy and toxicity of radiation therapy (RT) after radical prostatectomy (RP) for prostate cancer at Radiation Oncology Centres, Toowoomba. METHODS: The electronic medical records of 130 consecutive patients with histologically proven prostate adenocarcinoma who underwent post-prostatectomy RT between January 2008 and December 2014 were analysed. Primary endpoint was Biochemical Recurrence (BCR) after RT. BCR was defined by PSA > 0...
August 14, 2017: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/28797999/long-term-results-of-post-operative-pelvic-image-guided-intensity-modulated-radiotherapy-in-gynecological-malignancies
#20
Rashi Agrawal, Sowmiya Prithiviraj, Dinesh Singh, Vaishali Zamre, Sandeep Agrawal, Arun Kumar Goel, Kanika Gupta, Bala Subramanian
OBJECTIVE: To assess late clinical outcomes with image guided intensity modulated radiotherapy (IG- IMRT) in gynecological malignancies. PATIENTS AND METHODS: We have been practicing IG IMRT for gynecological malignancies since January 2009. Here we are presenting our experience with this modern technique at median follow up of 38 months. During whole treatment bladder filling protocol was followed. Both target volumes and critical structures were contoured according to RTOG guidelines...
May 2017: Gulf Journal of Oncology
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