keyword
MENU ▼
Read by QxMD icon Read
search

Onorati

keyword
https://www.readbyqxmd.com/read/29777507/rankl-expression-is-increased-in-circulating-mononuclear-cells-of-patients-with-calcific-aortic-stenosis
#1
Marcello Rattazzi, Elisabetta Faggin, Elisa Bertacco, Roberta Buso, Massimo Puato, Mario Plebani, Martina Zaninotto, Davide Condotta, Giacomo Zoppellaro, Leopoldo Pagliani, Giuseppe Tarantini, Sabino Iliceto, Elisa Covolo, Giuseppe Faggian, Francesco Onorati, Mikhail Dodonov, Alessandro Daniotti, Paola Pantano, Zoran Olivari, Giovanni Benfari, Paolo Pauletto
We aimed to investigate whether the expression of the OPG/RANK/RANKL triad in peripheral blood mononuclear cells (PBMC) and circulating levels of markers of ectopic mineralization (OPG, FGF-23, PPi) are modified in patients with calcific aortic valve disease (CAVD). We found that patients affected by CAVD (n = 50) had significantly higher circulating levels of OPG as compared to control individuals (p = 0.003). No differences between the two groups were found in FGF-23 and PPi levels. RANKL expression was higher in the PBMC from CAVD patients (p = 0...
May 17, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29708036/studies-on-sporadic-non-syndromic-thoracic-aortic-aneurysms-ii-alterations-of-extra-cellular-matrix-components-and-focal-adhesion-proteins
#2
Anna Chiarini, Francesco Onorati, Maddalena Marconi, Alessandra Pasquali, Cristina Patuzzo, Anna Malashicheva, Olga Irtyega, Giuseppe Faggian, Pier F Pignatti, Elisabetta Trabetti, Ubaldo Armato, Ilaria Dal Pra
Background Sporadic non-syndromic thoracic aortic aneurysms (SNSTAAs) are less well understood than familial non-syndromic or syndromic ones. Here, we focused on morphologic and molecular changes of the extracellular matrix of the tunica media of SNSTAAs. Design Single centre design. Methods Surgical media samples from seven SNSTAAs and seven controls underwent quantitative polymerase chain reaction, proteomics-bioinformatics, immunoblotting, histology and immunohistochemistry analysis. Results A down-regulation of Decorin mRNA with unchanged protein levels associated with a remarkable increase of collagen fibres...
June 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29708032/studies-on-sporadic-non-syndromic-thoracic-aortic-aneurysms-1-deregulation-of-jagged-notch-1-homeostasis-and-selection-of-synthetic-secretor-phenotype-smooth-muscle-cells
#3
Anna Chiarini, Francesco Onorati, Maddalena Marconi, Alessandra Pasquali, Cristina Patuzzo, Anna Malashichev, Olga Irtyega, Giuseppe Faggian, Pier F Pignatti, Elisabetta Trabetti, Ubaldo Armato, Ilaria Dal Pra
Background Sporadic non-syndromic thoracic aortic aneurysms (SNSTAAs) are less well understood than familial non-syndromic or syndromic ones. The study aimed at defining the peculiar morphologic and molecular changes occurring in the media layer of SNSTAAs. Design This study was based on a single centre design. Methods Media layer samples taken from seven carefully selected SNSTAAs and seven reference patients (controls) were investigated via quantitative polymerase chain reaction, proteomics-bioinformatics, immunoblotting, quantitative histology, and immunohistochemistry/immunofluorescence...
June 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29688344/dynamic-and-cell-specific-dach1-expression-in-human-neocortical-and-striatal-development
#4
Valentina Castiglioni, Andrea Faedo, Marco Onorati, Vittoria Dickinson Bocchi, Zhen Li, Raffaele Iennaco, Romina Vuono, Gaetano P Bulfamante, Luca Muzio, Gianvito Martino, Nenad Sestan, Roger A Barker, Elena Cattaneo
DACH1 is the human homolog of the Drosophila dachshund gene, which is involved in the development of the eye, nervous system, and limbs in the fly. Here, we systematically investigate DACH1 expression patterns during human neurodevelopment, from 5 to 21 postconceptional weeks. By immunodetection analysis, we found that DACH1 is highly expressed in the proliferating neuroprogenitors of the developing cortical ventricular and subventricular regions, while it is absent in the more differentiated cortical plate...
April 24, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29676943/impact-of-preoperative-thrombocytopenia-on-the-outcome-after-coronary-artery-bypass-grafting
#5
Wail Nammas, Magnus Dalén, Stefano Rosato, Riccardo Gherli, Daniel Reichart, Giuseppe Gatti, Francesco Onorati, Giuseppe Faggian, Marisa De Feo, Ciro Bancone, Sidney Chocron, Sorosh Khodabandeh, Giuseppe Santarpino, Antonino S Rubino, Daniele Maselli, Saverio Nardella, Antonio Salsano, Tiziano Gherli, Francesco Nicolini, Marco Zanobini, Matteo Saccocci, Karl Bounader, Paola D'Errigo, Tuomas Kiviniemi, Eeva-Maija Kinnunen, Andrea Perrotti, Juhani Airaksinen, Giovanni Mariscalco, Vito G Ruggieri, Fausto Biancari
The impact of thrombocytopenia on postoperative bleeding and other major adverse events after cardiac surgery is unclear. This issue was investigated in a series of patients who underwent isolated coronary artery bypass grafting (CABG) from the prospective, multicenter E-CABG registry. Preoperative thrombocytopenia was defined as preoperative platelet count <150 × 109 /L and it was considered moderate-severe when preoperative platelet count was <100 × 109 /L. Multilevel mixed-effects regression analysis was performed to adjust the effect of thrombocytopenia on outcomes for baseline and operative covariates as well as for interinstitutional differences in patient-blood management...
April 20, 2018: Platelets
https://www.readbyqxmd.com/read/29671878/targeting-autophagy-in-cancer
#6
REVIEW
Angelique V Onorati, Matheus Dyczynski, Rani Ojha, Ravi K Amaravadi
Autophagy is a conserved, self-degradation system that is critical for maintaining cellular homeostasis during stress conditions. Dysregulated autophagy has implications in health and disease. Specifically, in cancer, autophagy plays a dichotomous role by inhibiting tumor initiation but supporting tumor progression. Early results from clinical trials that repurposed hydroxychloroquine for cancer have suggested that autophagy inhibition may be a promising approach for advanced cancers. In this review of the literature, the authors present fundamental advances in the biology of autophagy, approaches to targeting autophagy, the preclinical rationale and clinical experience with hydroxychloroquine in cancer clinical trials, the potential role of autophagy in tumor immunity, and recent developments in next-generation autophagy inhibitors that have clinical potential...
April 19, 2018: Cancer
https://www.readbyqxmd.com/read/29665452/utility-of-glycated-hemoglobin-screening-in-patients-undergoing-elective-coronary-artery-surgery-prospective-cohort-study-from-the-e-cabg-registry
#7
Francesco Nicolini, Giuseppe Santarpino, Giuseppe Gatti, Daniel Reichart, Francesco Onorati, Giuseppe Faggian, Magnus Dalén, Sorosh Khodabandeh, Theodor Fischlein, Daniele Maselli, Saverio Nardella, Antonino S Rubino, Marisa De Feo, Antonio Salsano, Riccardo Gherli, Giovanni Mariscalco, Eeva-Maija Kinnunen, Vito G Ruggieri, Karl Bounader, Matteo Saccocci, Sidney Chocron, Juhani Airaksinen, Andrea Perrotti, Fausto Biancari
BACKGROUND: Patients with increased glycated hemoglobin (HbA1c) seem to be at increased risk of sternal wound infection (SWI) after coronary artery bypass grafting (CABG). However, it is unclear whether increased baseline HbA1c levels may affect other postoperative outcomes. MATERIAL AND METHODS: Data on preoperative levels of HbA1c were collected from 2606 patients undergoing elective isolated CABG from 2015 to 2016 and included in the prospective, multicenter E-CABG registry...
April 14, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29617352/loss-of-iswi-function-in-drosophila-nuclear-bodies-drives-cytoplasmic-redistribution-of-drosophila-tdp-43
#8
Luca Lo Piccolo, Rosa Bonaccorso, Andrea Attardi, Lorenzo Li Greci, Giulia Romano, Martina Sollazzo, Giorgio Giurato, Antonia Maria Rita Ingrassia, Fabian Feiguin, Davide F V Corona, Maria Cristina Onorati
Over the past decade, evidence has identified a link between protein aggregation, RNA biology, and a subset of degenerative diseases. An important feature of these disorders is the cytoplasmic or nuclear aggregation of RNA-binding proteins (RBPs). Redistribution of RBPs, such as the human TAR DNA-binding 43 protein (TDP-43) from the nucleus to cytoplasmic inclusions is a pathological feature of several diseases. Indeed, sporadic and familial forms of amyotrophic lateral sclerosis (ALS) and fronto-temporal lobar degeneration share as hallmarks ubiquitin-positive inclusions...
April 4, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29440275/prior-percutaneous-coronary-intervention-and-mortality-in-patients-undergoing-surgical-myocardial-revascularization-results-from-the-e-cabg-european-multicenter-study-on-coronary-artery-bypass-grafting-with-a-systematic-review-and-meta-analysis
#9
Giovanni Mariscalco, Stefano Rosato, Giuseppe F Serraino, Daniele Maselli, Magnus Dalén, Juhani K E Airaksinen, Daniel Reichart, Marco Zanobini, Francesco Onorati, Marisa De Feo, Riccardo Gherli, Giuseppe Santarpino, Antonino S Rubino, Giuseppe Gatti, Francesco Nicolini, Francesco Santini, Andrea Perrotti, Vito D Bruno, Vito G Ruggieri, Fausto Biancari
BACKGROUND: The clinical impact of prior percutaneous coronary intervention (PCI) in patients requiring coronary artery bypass grafting (CABG) remains unsettled. We sought to determine whether prior PCI is associated with adverse outcome after CABG. METHODS AND RESULTS: Data from the prospective E-CABG (European Multicenter Study on Coronary Artery Bypass Grafting) conducted between January 2015 and March 2016 at 16 European centres were analyzed using propensity weighted methodology to adjust for confounding...
February 2018: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29440154/outcomes-comparison-of-different-surgical-strategies-for-the-management-of-severe-aortic-valve-stenosis-study-protocol-of-a-prospective-multicentre-european-registry-e-avr-registry
#10
Francesco Onorati, Riccardo Gherli, Giovanni Mariscalco, Evaldas Girdauskas, Eduardo Quintana, Francesco Santini, Marisa De Feo, Sandro Sponga, Piergiorgio Tozzi, Mohamad Bashir, Andrea Perrotti, Aniello Pappalardo, Vito Giovanni Ruggieri, Giuseppe Santarpino, Mauro Rinaldi, Silva Ronaldo, Francesco Nicolini
INTRODUCTION: Traditional and transcatheter surgical treatments of severe aortic valve stenosis (SAVS) are increasing in parallel with the improved life expectancy. Recent randomised controlled trials (RCTs) reported comparable or non-inferior mortality with transcatheter treatments compared with traditional surgery. However, RCTs have the limitation of being a mirror of the predefined inclusion/exclusion criteria, without reflecting the 'real clinical world'. Technological improvements have recently allowed the development of minimally invasive surgical accesses and the use of sutureless valves, but their impact on the clinical scenario is difficult to assess because of the monocentric design of published studies and limited sample size...
February 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29410264/early-outcome-of-bilateral-versus-single-internal-mammary-artery-grafting-in-the-elderly
#11
Antonino S Rubino, Giuseppe Gatti, Daniel Reichart, Tuomas Tauriainen, Marisa De Feo, Francesco Onorati, Aniello Pappalardo, Sidney Chocron, Helmut Gulbins, Magnus Dalén, Peter Svenarud, Giuseppe Faggian, Ilaria Franzese, Giuseppe Santarpino, Theodor Fischlein, Daniele Maselli, Saverio Nardella, Riccardo Gherli, Aamer Ahmed, Francesco Santini, Antonio Salsano, Francesco Nicolini, Marco Zanobini, Matteo Saccocci, Vito G Ruggieri, Karl Bounader, Carmelo Mignosa, Paola D'Errigo, Stefano Rosato, Juhani Airaksinen, Andrea Perrotti, Fausto Biancari
BACKGROUND: Bilateral internal mammary artery (BIMA) grafting is increasingly used in the elderly without evidence of its risks or benefits compared to single internal mammary artery (SIMA) grafting. METHODS: 2899 patients aged 70 years or older (855 underwent BIMA grafting, 29.5%) operated on from January 2015 to December 2016 and included in the prospective multicenter E-CABG study were considered in this analysis. RESULTS: One-to-one propensity matching resulted in 804 pairs with similar preoperative risk profile...
February 1, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29398138/corrigendum-to-a-predictive-model-for-early-mortality-after-surgical-treatment-of-heart-valve-or-prosthesis-infective-endocarditis-the-endoscore-int-j-cardiol-241-aug-15-2017-97-102
#12
Michele Di Mauro, Guglielmo Mario Actis Dato, Fabio Barili, Sandro Gelsomino, Pasquale Santè, Alessandro Della Corte, Antonio Carrozza, Ester Della Ratta, Diego Cugola, Lorenzo Galletti, Roger Devotini, Riccardo Casabona, Francesco Santini, Antonio Salsano, Roberto Scrofani, Carlo Antona, Luca Botta, Claudio Russo, Samuel Mancuso, Mauro Rinaldi, Carlo De Vincentiis, Andrea Biondi, Cesare Beghi, Giangiuseppe Cappabianca, Vincenzo Tarzia, Gino Gerosa, Michele De Bonis, Alberto Pozzoli, Francesco Nicolini, Filippo Benassi, Francesco Rosato, Elena Grasso, Ugolino Livi, Sandro Sponga, Davide Pacini, Roberto Di Bartolomeo, Andrea DeMartino, Uberto Bortolotti, Francesco Onorati, Giuseppe Faggian, Roberto Lorusso, Enrico Vizzardi, Gabriele Di Giammarco, Daniele Marinelli, Emmanuel Villa, Giovanni Troise, Marco Picichè, Francesco Musumeci, Domenico Paparella, Vito Margari, Francesco Tritto, Girolamo Damiani, Giuseppe Scrascia, Salvatore Zaccaria, Attilio Renzulli, Giuseppe Serraino, Giovanni Mariscalco, Daniele Maselli, Massimiliano Foschi, Alessandro Parolari, Giannantonio Nappi
No abstract text is available yet for this article.
May 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29325846/hospital-outcome-and-risk-indices-of-mortality-after-redo-mitral-valve-surgery-in-potential-candidates-for-transcatheter-procedures-results-from-a-european-registry
#13
Francesco Onorati, Giovanni Mariscalco, Daniel Reichart, Andrea Perrotti, Giuseppe Gatti, Marisa De Feo, Antonio Rubino, Giuseppe Santarpino, Fausto Biancari, Christian Detter, Francesco Santini, Giuseppe Faggian
OBJECTIVE: Transcatheter mitral valve-in-valve/valve-in-ring procedures (TM-VIVoR) are increasing. The authors aimed to identify independent predictors for hospital mortality in redo mitral valve surgery as possible future selection criteria for TM-VIVoR. DESIGN: Retrospective multicenter registry. SETTING: Tertiary university and community hospitals. PARTICIPANTS: Two-hundred and sixty patients (out of 920 enrolled) who are potentially candidates for TM-VIVoR undergoing redo-surgery...
April 2018: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29304418/cortical-sources-of-resting-state-electroencephalographic-rhythms-probe-brain-function-in-na%C3%A3-ve-hiv-individuals
#14
Claudio Babiloni, Giuseppe Noce, Alfredo Pennica, Paolo Onorati, Paolo Capotosto, Claudio Del Percio, Paolo Roma, Valentina Correr, Elisa Piccinni, Ginevra Toma, Andrea Soricelli, Francesco Di Campli, Laura Gianserra, Lorenzo Ciullini, Antonio Aceti, Elisabetta Teti, Loredana Sarmati, Gloria Crocetti, Raffaele Ferri, Valentina Catania, Maria Teresa Pascarelli, Massimo Andreoni, Stefano Ferracuti
OBJECTIVE: Here we evaluated the hypothesis that resting state electroencephalographic (EEG) cortical sources correlated with cognitive functions and discriminated asymptomatic treatment-naïve HIV subjects (no AIDS). METHODS: EEG, clinical, and neuropsychological data were collected in 103 treatment-naïve HIV subjects (88 males; mean age 39.8 years ± 1.1 standard error of the mean, SE). An age-matched group of 70 cognitively normal and HIV-negative (Healthy; 56 males; 39...
December 20, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29276146/prognostic-impact-of-prolonged-cross-clamp-time-in-coronary-artery-bypass-grafting
#15
Vito G Ruggieri, Karl Bounader, Jean Philippe Verhoye, Francesco Onorati, Antonino S Rubino, Giuseppe Gatti, Tuomas Tauriainen, Marisa De Feo, Daniel Reichart, Magnus Dalén, Peter Svenarud, Giuseppe Faggian, Giuseppe Santarpino, Daniele Maselli, Riccardo Gherli, Giovanni Mariscalco, Antonio Salsano, Francesco Nicolini, Tiziano Gherli, Matteo Saccocci, Juhani K E Airaksinen, Sidney Chocron, Andrea Perrotti, Fausto Biancari
BACKGROUND: The prognostic impact of cross-clamp time (XCT) in patients undergoing isolated coronary artery bypass grafting (CABG) has not been thoroughly investigated. MATERIAL AND METHODS: 2957 patients who underwent on-pump isolated CABG from the prospective multicentre E-CABG study were the subjects of this analysis. RESULTS: The mean XCT in this series was 58±25minutes Cross-clamp time was >60 minutes in 1134 patients (38.3%), >75minutes in 619 patients (20...
October 6, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29243154/nitrate-trends-in-groundwater-of-the-campania-region-southern-italy
#16
Daniela Ducci, Renata Della Morte, Adolfo Mottola, Giuseppe Onorati, Giovanni Pugliano
The Environmental Protection Agency of the Campania region in Italy (ARPAC) manages a groundwater quality monitoring network. For almost all the polluted waters, the key parameter driving the classification is the concentration of nitrate; hence, the Campania region, in coherence with the EU regulations, outlined the vulnerable areas and undertook remediation policies. The best groundwater quality is recorded for carbonate aquifers of the Apennine chain; on the contrary, the Tyrrhenian coastal plains are affected by severe contamination, with a locally very contaminated groundwater of the shallow and also the deeper aquifers...
December 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29170230/molecular-and-cellular-reorganization-of-neural-circuits-in-the-human-lineage
#17
André M M Sousa, Ying Zhu, Mary Ann Raghanti, Robert R Kitchen, Marco Onorati, Andrew T N Tebbenkamp, Bernardo Stutz, Kyle A Meyer, Mingfeng Li, Yuka Imamura Kawasawa, Fuchen Liu, Raquel Garcia Perez, Marta Mele, Tiago Carvalho, Mario Skarica, Forrest O Gulden, Mihovil Pletikos, Akemi Shibata, Alexa R Stephenson, Melissa K Edler, John J Ely, John D Elsworth, Tamas L Horvath, Patrick R Hof, Thomas M Hyde, Joel E Kleinman, Daniel R Weinberger, Mark Reimers, Richard P Lifton, Shrikant M Mane, James P Noonan, Matthew W State, Ed S Lein, James A Knowles, Tomas Marques-Bonet, Chet C Sherwood, Mark B Gerstein, Nenad Sestan
To better understand the molecular and cellular differences in brain organization between human and nonhuman primates, we performed transcriptome sequencing of 16 regions of adult human, chimpanzee, and macaque brains. Integration with human single-cell transcriptomic data revealed global, regional, and cell-type-specific species expression differences in genes representing distinct functional categories. We validated and further characterized the human specificity of genes enriched in distinct cell types through histological and functional analyses, including rare subpallial-derived interneurons expressing dopamine biosynthesis genes enriched in the human striatum and absent in the nonhuman African ape neocortex...
November 24, 2017: Science
https://www.readbyqxmd.com/read/29154375/glial-choristoma-of-the-ventral-part-of-the-tongue-first-report-in-an-elderly-patient
#18
M Nicola, F Ferrario, P Collini, M Onorati, M M Albertoni, F Di Nuovo
INTRODUCTION: The aims of this report are to illustrate the first case of glial and adipose tissue choristoma at the ventral part of the tongue in an elderly patient, to discuss the possible differential diagnoses and to speculate about its pathogenesis. CASE REPORT: A 65-year-old female was admitted to our hospital with a swelling at the base of the tongue. MRI revealed an oval lesion with indistinct borders without contrast enhancement. The patient underwent surgical complete excision and grossly, the specimen consisted of a gray-white mass measuring 25 mm in its great diameter...
September 2017: Pathologica
https://www.readbyqxmd.com/read/28987158/atrial-function-as-an-independent-predictor-of%C3%A2-postoperative-atrial-fibrillation-in-patients-undergoing-aortic-valve-surgery-for-severe-aortic%C3%A2-stenosis
#19
Matteo Pernigo, Giovanni Benfari, Giulia Geremia, Manjola Noni, Gianluca Borio, Gloria Mazzali, Mauro Zamboni, Francesco Onorati, Giuseppe Faggian, Corrado Vassanelli, Andrea Rossi
BACKGROUND: Postoperative atrial fibrillation (POAF) is a common, clinically relevant, but hardly predictable complication after surgical aortic valve replacement. The aim of this study was to test the role of preoperative left atrial longitudinal strain as a predictor of POAF in clinical practice. METHODS: Sixty patients scheduled for aortic valve replacement for severe isolated aortic stenosis, in stable sinus rhythm, were prospectively enrolled and underwent full clinical, biochemical, and transthoracic echocardiographic assessment on the day before surgery...
October 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28980315/multicenter-clinical-assessment-of-improved-wearable-multimodal-convulsive-seizure-detectors
#20
MULTICENTER STUDY
Francesco Onorati, Giulia Regalia, Chiara Caborni, Matteo Migliorini, Daniel Bender, Ming-Zher Poh, Cherise Frazier, Eliana Kovitch Thropp, Elizabeth D Mynatt, Jonathan Bidwell, Roberto Mai, W Curt LaFrance, Andrew S Blum, Daniel Friedman, Tobias Loddenkemper, Fatemeh Mohammadpour-Touserkani, Claus Reinsberger, Simone Tognetti, Rosalind W Picard
OBJECTIVE: New devices are needed for monitoring seizures, especially those associated with sudden unexpected death in epilepsy (SUDEP). They must be unobtrusive and automated, and provide false alarm rates (FARs) bearable in everyday life. This study quantifies the performance of new multimodal wrist-worn convulsive seizure detectors. METHODS: Hand-annotated video-electroencephalographic seizure events were collected from 69 patients at six clinical sites. Three different wristbands were used to record electrodermal activity (EDA) and accelerometer (ACM) signals, obtaining 5,928 h of data, including 55 convulsive epileptic seizures (six focal tonic-clonic seizures and 49 focal to bilateral tonic-clonic seizures) from 22 patients...
November 2017: Epilepsia
keyword
keyword
43148
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"