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Claudio Babiloni, Alfredo Pennica, Paolo Capotosto, Paolo Onorati, Chiara Muratori, Stefano Ferracuti, Paolo Roma, Valentina Correr, Elisa Piccinni, Giuseppe Noce, Claudio Del Percio, Susanna Cordone, Cristina Limatola, Andrea Soricelli, Francesco Di Campli, Laura Gianserra, Lorenzo Ciullini, Antonio Aceti, Magdalena Viscione, Elisabetta Teti, Loredana Sarmati, Massimo Andreoni
OBJECTIVE: Cortical sources of electroencephalographic (EEG) rhythms were investigated in two sub-populations of naïve HIV subjects, grouped based on clinical criteria to receive different combination anti-retroviral therapies (cARTs). These EEG sources were hypothesized to reflect beneficial effects of both regimes. METHODS: Eyes-closed resting state EEG data were collected in 19 (Group A) and 39 (Group B) naïve HIV subjects at baseline (i.e. pre-treatment; T0) and after 5months of cART (T5)...
September 9, 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
Marco Onorati, Zhen Li, Fuchen Liu, André M M Sousa, Naoki Nakagawa, Mingfeng Li, Maria Teresa Dell'Anno, Forrest O Gulden, Sirisha Pochareddy, Andrew T N Tebbenkamp, Wenqi Han, Mihovil Pletikos, Tianliuyun Gao, Ying Zhu, Candace Bichsel, Luis Varela, Klara Szigeti-Buck, Steven Lisgo, Yalan Zhang, Anze Testen, Xiao-Bing Gao, Jernej Mlakar, Mara Popovic, Marie Flamand, Stephen M Strittmatter, Leonard K Kaczmarek, E S Anton, Tamas L Horvath, Brett D Lindenbach, Nenad Sestan
The mechanisms underlying Zika virus (ZIKV)-related microcephaly and other neurodevelopment defects remain poorly understood. Here, we describe the derivation and characterization, including single-cell RNA-seq, of neocortical and spinal cord neuroepithelial stem (NES) cells to model early human neurodevelopment and ZIKV-related neuropathogenesis. By analyzing human NES cells, organotypic fetal brain slices, and a ZIKV-infected micrencephalic brain, we show that ZIKV infects both neocortical and spinal NES cells as well as their fetal homolog, radial glial cells (RGCs), causing disrupted mitoses, supernumerary centrosomes, structural disorganization, and cell death...
September 6, 2016: Cell Reports
Giovanni Benfari, Rajesh Dandale, Andrea Rossi, Francesco Onorati, Giacomo Mugnai, Flavio Ribichini, Pier L Temporelli, Corrado Vassanelli
Functional mitral regurgitation is a form of valve insufficiency in the presence of anatomically normal mitral valve. The cause of functional mitral regurgitation is left ventricular remodelling that tethers valve leaflet more apically decreasing their coaptation ability. Given the pathophysiologic relation between functional mitral regurgitation and ventricular dysfunction, the valve insufficiency has long been considered a surrogate of ventricular disease. Accordingly, all potential therapeutic strategies able to decrease functional mitral regurgitation have been associated with improved ventricular function...
November 2016: Journal of Cardiovascular Medicine
Paola D'Errigo, Marco Ranucci, Remo Daniel Covello, Fausto Biancari, Stefano Rosato, Marco Barbanti, Francesco Onorati, Corrado Tamburino, Gennaro Santoro, Claudio Grossi, Francesco Santini, Katia Bontempi, Danilo Fusco, Fulvia Seccareccia
OBJECTIVE: To evaluate outcomes of monitored anesthesia care (MAC) compared with general anesthesia (GA) in patients undergoing transfemoral transcatheter aortic valve replacement (TAVR). DESIGN: Secondary analysis from the observational and prospective OBSERVANT (OBservational Study of Effectiveness of avR-taVi procedures for severe Aortic steNosis Treatment) study. SETTING: Multicenter study, including Italian hospitals performing TAVR interventions...
October 2016: Journal of Cardiothoracic and Vascular Anesthesia
Michela Onorati, Giulia Sancesario, Donatella Pastore, Sergio Bernardini, Jorge E Carrión, Monica Carosi, Leonardo Vignoli, Davide Lauro, Gabriele Gentile
In a combined approach, endocrine and ultrasonic analyses were performed to assess reproduction of two syntopic populations of terrestrial Galápagos iguanas the Conolophus marthae (the Galápagos Pink Land Iguana) and C. subcristatus on the Volcán Wolf (Isabela Island). The ELISA methods (enzyme-linked immunosorbent assay) were used to measure plasma concentrations of progesterone (P4) and 17β-estradiol (E2) from samples collected over the course of three different seasons: July 2010, June 2012-2014. As for C...
September 2016: Animal Reproduction Science
Claudio Babiloni, Alfredo Pennica, Claudio Del Percio, Giuseppe Noce, Susanna Cordone, Susanna Lopez, Ketura Berry, Chiara Muratori, Stefano Ferracuti, Paolo Roma, Valentina Correr, Francesco Di Campli, Laura Gianserra, Lorenzo Ciullini, Antonio Aceti, Andrea Soricelli, Elisabetta Teti, Magdalena Viscione, Cristina Limatola, Paolo Onorati, Paolo Capotosto, Massimo Andreoni
OBJECTIVE: Here we tested the effect of combined antiretroviral therapy (cART) on deviant electroencephalographic (EEG) source activity in treatment-naïve HIV individuals. METHODS: Resting state eyes-closed EEG data were recorded before and after 5 months of cART in 48 male HIV subjects, who were naïve at the study start. The EEG data were also recorded in 59 age- and sex-matched healthy subjects as a control group. Frequency bands of interest included delta, theta, alpha1, alpha2 and alpha3, based on alpha frequency peak specific to each individual...
2016: NeuroImage: Clinical
Marco Onorati, Maurizio Binetti, Luciano Conti, Stefano Camnasio, Giovanna Calabrese, Ilaria Albieri, Francesca Di Febo, Mauro Toselli, Gerardo Biella, Ben Martynoga, Francois Guillemot, G Giacomo Consalez, Elena Cattaneo
No abstract text is available yet for this article.
July 12, 2016: Cellular and Molecular Life Sciences: CMLS
Fausto Biancari, Tuomas Tauriainen, Andrea Perrotti, Magnus Dalén, Giuseppe Faggian, Ilaria Franzese, Sidney Chocron, Vito G Ruggieri, Karl Bounader, Helmut Gulbins, Daniel Reichart, Peter Svenarud, Giuseppe Santarpino, Theodor Fischlein, Tamas Puski, Daniele Maselli, Carmelo Dominici, Saverio Nardella, Giovanni Mariscalco, Riccardo Gherli, Francesco Musumeci, Antonino S Rubino, Carmelo Mignosa, Marisa De Feo, Ciro Bancone, Giuseppe Gatti, Luca Maschietto, Francesco Santini, Antonio Salsano, Francesco Nicolini, Tiziano Gherli, Marco Zanobini, Matteo Saccocci, Paola D'Errigo, Eeva-Maija Kinnunen, Francesco Onorati
INTRODUCTION: This study was planned to investigate the impact of severe bleeding and blood transfusion on the development of stroke after coronary surgery. METHODS: This cohort study includes 2357 patients undergoing isolated CABG from the prospective European Coronary Artery Bypass Grafting (E-CABG) registry. Severity of bleeding was categorized according to the Universal Definition of Perioperative Bleeding (UDPB), E-CABG and PLATO definitions. RESULTS: Thirty patients (1...
August 2016: International Journal of Surgery
Francesco Vasques, Eeva-Maija Kinnunen, Marek Pol, Giovanni Mariscalco, Francesco Onorati, Fausto Biancari
BACKGROUND: The objective was to evaluate the early outcome after adult cardiac surgery in Jehovah's Witnesses (JWs) compared with controls not refusing blood transfusions. STUDY DESIGN AND METHODS: A literature review was performed through PubMed, Scopus, and Google Scholar to identify any comparative study evaluating the outcome of JWs and patients not refusing blood transfusion after adult cardiac surgery. RESULTS: Six studies comparing the outcome of 564 JWs and 903 controls fulfilled the inclusion criteria of this study...
August 2016: Transfusion
Stefano Rosato, Francesco Santini, Marco Barbanti, Fausto Biancari, Paola D'Errigo, Francesco Onorati, Corrado Tamburino, Marco Ranucci, Remo Daniel Covello, Gennaro Santoro, Claudio Grossi, Martina Ventura, Danilo Fusco, Fulvia Seccareccia
BACKGROUND: The proven efficacy of transcatheter aortic valve implantation (TAVI) in high-risk patients is leading to the expansion of its indications toward lower-risk patients. However, this shift is not supported by meaningful evidence of its benefit over surgical aortic valve replacement (SAVR). This analysis aims to describe outcomes of TAVI versus SAVR in low-risk patients. METHODS AND RESULTS: We compared the outcome after TAVI and SAVR of low-risk patients (European System for Cardiac Operative Risk Evaluation II [EuroSCORE II] <4%) included in the Observational Study of Effectiveness of SAVR-TAVI Procedures for Severe Aortic Stenosis Treatment (OBSERVANT) study...
May 2016: Circulation. Cardiovascular Interventions
Milena Maule, Daniela Zugna, Enrica Migliore, Daniela Alessi, Franco Merletti, Roberta Onorati, Nicolás Zengarini, Giuseppe Costa, Teresa Spadea
Long-term consequences of childhood cancer encompass adverse psychosocial effects that may severely limit the opportunity to live a satisfying and productive life. We assessed the social integration of adults cured of a cancer in their first 14 years of life by record linkage between the population-based Childhood Cancer Registry of Piedmont and the Turin Longitudinal Study. We compared education and employment outcomes within the cohort of survivors and between the cohort of survivors and their peers in the general population through logistic regression...
April 29, 2016: European Journal of Cancer Prevention
Paola D'Errigo, Claudio Moretti, Fabrizio D'Ascenzo, Stefano Rosato, Fausto Biancari, Marco Barbanti, Francesco Santini, Marco Ranucci, Antonio Miceli, Corrado Tamburino, Francesco Onorati, Gennaro Santoro, Claudio Grossi, Danilo Fusco, Fulvia Seccareccia
BACKGROUND: There are scarce data on outcomes after transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR) in patients with renal failure. METHODS: We evaluated the impact of renal failure on outcomes after TAVI and SAVR and compared the results of these procedures in patients with chronic kidney disease stages 3b to 5 from the Observational Study of Effectiveness of AVR-TAVI Procedures for Severe Aortic Stenosis Treatment (OBSERVANT) study...
August 2016: Annals of Thoracic Surgery
Marco Romano, Teresa Onorati, Ignacio Aedo, Paloma Diaz
When an emergency occurs, citizens can be a helpful support for the operation centers involved in the response activities. As witnesses to a crisis, they initially can share updated and detailed information about what is going on. Moreover, thanks to the current technological evolution people are able to quickly and easily gather rich information and transmit it through different communication channels. Indeed, modern mobile devices embed several sensors such as GPS receivers, Wi-Fi, accelerometers or cameras that can transform users into well-equipped human sensors...
2016: Sensors
Chiara Fraccaro, Giuseppe Tarantini, Stefano Rosato, Paola Tellaroli, Paola D'Errigo, Corrado Tamburino, Francesco Onorati, Marco Ranucci, Marco Barbanti, Claudio Grossi, Gennaro Santoro, Francesco Santini, Remo Daniel Covello, Danilo Fusco, Fulvia Seccareccia
The aim of this study was to analyze procedural and postprocedural outcomes of patients aged ≥80 years treated by transcatheter aortic valve implantation (TAVI) or surgical aortic valve replacement (SAVR) as enrolled in the OBservational Study of Effectiveness of SAVR-TAVR procedures for severe Aortic steNosis Treatment (OBSERVANT) Study. TAVI is offered to patients with aortic stenosis judged inoperable or at high surgical risk. Nevertheless, it is common clinical practice to treat elderly (≥80 years) patients by TAVI regardless of surgical risk for traditional SAVR...
May 1, 2016: American Journal of Cardiology
Francesco Onorati, Andrea Perrotti, Daniel Reichart, Giovanni Mariscalco, Ester Della Ratta, Giuseppe Santarpino, Antonio Salsano, Antonio Rubino, Fausto Biancari, Giuseppe Gatti, Cesare Beghi, Marisa De Feo, Carmelo Mignosa, Aniello Pappalardo, Theodor Fischlein, Sidney Chocron, Christian Detter, Francesco Santini, Giuseppe Faggian
OBJECTIVES: Several single-centre experiences have reported significant operative mortality and morbidity after mitral valve surgery in redo scenarios (ReMVS). Several preoperative risk factors outlining 'high-risk' categories have been reported, but scanty data on the impact of different operative techniques for these major challenging procedures have been analysed to date. The aim of the study is to investigate those intraoperative factors and postoperative events affecting early survival after redo mitral procedures...
May 2016: European Journal of Cardio-thoracic Surgery
Francesco Onorati, Augusto D'Onofrio, Fausto Biancari, Stefano Salizzoni, Marisa De Feo, Marco Agrifoglio, Giovanni Mariscalco, Vincenzo Lucchetti, Antonio Messina, Francesco Musumeci, Giuseppe Santarpino, Giampiero Esposito, Francesco Santini, Paolo Magagna, Cesare Beghi, Marco Aiello, Ester Dalla Ratta, Carlo Savini, Giovanni Troise, Mauro Cassese, Theodor Fischlein, Mattia Glauber, Giancarlo Passerone, Giuseppe Punta, Tatu Juvonen, Ottavio Alfieri, Davide Gabbieri, Domenico Mangino, Andrea Agostinelli, Ugolino Livi, Omar Di Gregorio, Alessandro Minati, Mauro Rinaldi, Gino Gerosa, Giuseppe Faggian
OBJECTIVES: To evaluate the results of aortic valve replacement through sternotomic approach in redo scenarios (RAVR) vs transapical transcatheter aortic valve replacement (TAVR), in patients in the eighth decade of life or older already undergone previous coronary artery bypass grafting (CABG). METHODS: One hundred and twenty-six patients undergoing RAVR were compared with 113 patients undergoing TaTAVR in terms of 30-day mortality and Valve Academic Research Consortium-2 outcomes...
June 2016: Interactive Cardiovascular and Thoracic Surgery
Antonio Salsano, Tommaso Regesta, Gaia Viganò, Filippo Rapetto, Serena Boeddu, Elena Sportelli, Stefano Pansini, Paolo Risso, Francesco Onorati, Giancarlo Passerone, Francesco Santini
BACKGROUND: In the transcatheter aortic valve implantation (TAVI) years, very elderly patients with aortic stenosis (AS) are referred to surgery with reluctance despite excellent hospital outcomes. A poorly assessed outcome of discharged survivors might further overlook the actual efficacy of the surgical strategy in this cohort. We thus evaluated life-expectancy and functional results in discharged survivors over 85 years operated on for AS. METHODS: Between January 2001 and December 2013, 57 consecutive patients aged ≥85 years underwent aortic valve replacement (AVR) with or without concomitant procedures at our institution...
February 2016: International Journal of Artificial Organs
M Onorati, P Uboldi, C L Bianchi, M Nicola, G M Corradini, S Veronese, A I Fascì, F Di Nuovo
Thyroid gland is one of the most vascularized organs of the body, nevertheless clinical and surgical series report an incidence of secondary malignancies in this gland of only 3%. Colorectal carcinoma metastatic to the thyroid gland is not as uncommon as previously believed, infact the number of cases seems to be increased in recent years due to the more frequent use of fine-needle aspiration cytology (FNAC) guided by ultrasonography. Although kidney, breast and lung metastases to the thyroid are frequent, metastasis from colon cancer is clinically rare with 52 cases reported in the literature in the last 5 decades and three cases described as solitary thyroid metastasis from the colon cancer without any other visceral metastases...
September 2015: Pathologica
Marco Anile, Daniele Diso, Ilaria Onorati, Sara Mantovani, Federico Venuta
No abstract text is available yet for this article.
July 2016: Thorax
Monica Onorati, Marta Nicola, Chiara Luisa Bianchi, Francesco Bini, Nadia Bellaviti, Franca Di Nuovo
BACKGROUND: The aim of the current case report is to re-evaluate the key features and pitfalls of fine-needle aspiration cytology (FNAC) in the diagnosis of sclerosing pneumocytoma (previously named sclerosing hemangioma) and to establish the importance of FNAC in addressing a proper surgical strategy. CASE: Herein we documented a case of a 70- year-old man with a lung nodule which showed a hypermetabolic uptake on positron emission tomography. He therefore underwent FNAC under computed tomography scan guidance with a 22-gauge needle...
2016: Acta Cytologica
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