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https://www.readbyqxmd.com/read/28701502/wrist-sensor-reveals-sympathetic-hyperactivity-and-hypoventilation-before-probable-sudep
#1
Rosalind W Picard, Matteo Migliorini, Chiara Caborni, Francesco Onorati, Giulia Regalia, Daniel Friedman, Orrin Devinsky
No abstract text is available yet for this article.
July 12, 2017: Neurology
https://www.readbyqxmd.com/read/28550804/dispersant-approval-procedures-in-france-and-italy-a-comparative-ecotoxicity-study
#2
Loredana Manfra, Andrea Tornambè, Julien Guyomarch, Pascale Le Guerrogue, Loïc Kerambrun, Alice Rotini, Federica Savorelli, Fulvio Onorati, Erika Magaletti
A research project has been performed to the request of the RAMOGE Executive Secretariat to identify differences between dispersant approval procedures in France and Italy and propose ways to harmonize them. A collaborative study has been conducted by CEDRE (Centre of Documentation, Research and Experimentation on Accidental Water Pollution) and ISPRA (Italian Institute for Environmental Protection and Research) to: a) compare current approval procedures in Italy and France with identification of differences and commonalities; b) carry out toxicity tests using both procedures on two selected dispersants; c) propose a common approach between Italy and France...
May 24, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28540065/dynamic-and-quantitative-evaluation-of-degenerative-mitral-valve-disease-a-dedicated-framework-based-on-cardiac-magnetic-resonance-imaging
#3
Francesco Sturla, Francesco Onorati, Giovanni Puppini, Omar A Pappalardo, Matteo Selmi, Emiliano Votta, Giuseppe Faggian, Alberto Redaelli
BACKGROUND: Accurate quantification of mitral valve (MV) morphology and dynamic behavior over the cardiac cycle is crucial to understand the mechanisms of degenerative MV dysfunction and to guide the surgical intervention. Cardiac magnetic resonance (CMR) imaging has progressively been adopted to evaluate MV pathophysiology, although a dedicated framework is required to perform a quantitative assessment of the functional MV anatomy. METHODS: We investigated MV dynamic behavior in subjects with normal MV anatomy (n=10) and patients referred to surgery due to degenerative MV prolapse, classified as fibro-elastic deficiency (FED, n=9) and Barlow's disease (BD, n=10)...
April 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28445858/the-impact-of-minor-blood-transfusion-on-the-outcome-after-coronary-artery-bypass-grafting
#4
Eeva-Maija Kinnunen, Marco Zanobini, Francesco Onorati, Debora Brascia, Giovanni Mariscalco, Ilaria Franzese, Vito G Ruggieri, Karl Bounader, Andrea Perrotti, Francesco Musumeci, Giuseppe Santarpino, Daniele Maselli, Saverio Nardella, Helmut Gulbins, Riccardo Gherli, Antonino S Rubino, Carmelo Mignosa, Marisa De Feo, Giuseppe Gatti, Francesco Santini, Antonio Salsano, Magnus Dalén, Matteo Saccocci, Daniel Reichart, Giuseppe Faggian, Tiziano Gherli, Francesco Nicolini, Fausto Biancari
PURPOSE: To investigate the impact of minor perioperative bleeding requiring transfusion of 1-2 red blood cell (RBC) units on the outcome after coronary artery bypass grafting (CABG). METHODS: Sixteen cardiac surgical centers contributed to the prospective European CABG registry (E-CABG). 1014 patients receiving 1-2 RBC units during or after isolated CABG were compared to 2264 patients not receiving RBCs. RESULTS: In 827 propensity score matched pairs, transfusion of 1-2 RBC units did not affect the risk of in-hospital/30-day death (p=0...
April 19, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28390740/a-predictive-model-for-early-mortality-after-surgical-treatment-of-heart-valve-or-prosthesis-infective-endocarditis-the-endoscore
#5
Michele Di Mauro, Guglielmo Mario Actis Dato, Fabio Barili, Sandro Gelsomino, Pasquale Santè, Alessandro Della Corte, Antonio Carrozza, Ester Della Ratta, Diego Cugola, Lorenzo Galletti, Roger Devotini, Riccardo Casabona, Francesco Santini, Antonio Salsano, Roberto Scrofani, Carlo Antona, Luca Botta, Claudio Russo, Samuel Mancuso, Mauro Rinaldi, Carlo De Vincentiis, Andrea Biondi, Cesare Beghi, Giangiuseppe Cappabianca, Vincenzo Tarzia, Gino Gerosa, Michele De Bonis, Alberto Pozzoli, Francesco Nicolini, Filippo Benassi, Francesco Rosato, Elena Grasso, Ugolino Livi, Sponga Sandro, Davide Pacini, Roberto Di Bartolomeo, Andrea De Martino, Uberto Bortolotti, Francesco Onorati, Giuseppe Faggian, Roberto Lorusso, Enrico Vizzardi, Gabriele Di Giammarco, Daniele Marinelli, Emmanuel Villa, Giovanni Troise, Marco Picichè, Francesco Musumeci, Domenico Paparella, Vito Margari, Francesco Tritto, Girolamo Damiani, Giuseppe Scrascia, Salvatore Zaccaria, Attilio Renzulli, Giuseppe Serraino, Giovanni Mariscalco, Daniele Maselli, Massimiliano Foschi, Alessandro Parolari, Giannantonio Nappi
BACKGROUND: The aim of this large retrospective study was to provide a logistic risk model along an additive score to predict early mortality after surgical treatment of patients with heart valve or prosthesis infective endocarditis (IE). METHODS: From 2000 to 2015, 2715 patients with native valve endocarditis (NVE) or prosthesis valve endocarditis (PVE) were operated on in 26 Italian Cardiac Surgery Centers. The relationship between early mortality and covariates was evaluated with logistic mixed effect models...
April 4, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28389122/venoarterial-extracorporeal-membrane-oxygenation-after-coronary-artery-bypass-grafting-results-of-a-multicenter-study
#6
Fausto Biancari, Magnus Dalén, Andrea Perrotti, Antonio Fiore, Daniel Reichart, Sorosh Khodabandeh, Helmut Gulbins, Svante Zipfel, Mosab Al Shakaki, Henryk Welp, Antonella Vezzani, Tiziano Gherli, Jaakko Lommi, Tatu Juvonen, Peter Svenarud, Sidney Chocron, Jean Philippe Verhoye, Karl Bounader, Giuseppe Gatti, Marco Gabrielli, Matteo Saccocci, Eeva-Maija Kinnunen, Francesco Onorati, Giuseppe Santarpino, Khalid Alkhamees, Vito G Ruggieri, Angelo M Dell'Aquila
BACKGROUND: The evidence of the benefits of using venoarterial extracorporeal membrane oxygenation (VA-ECMO) after coronary artery bypass grafting (CABG) is scarce. METHODS: We analyzed the outcomes of patients who received VA-ECMO therapy due to cardiac or respiratory failure after isolated CABG in 12 centers between 2005 and 2016. Patients treated preoperatively with ECMO were excluded from this study. RESULTS: VA-ECMO was employed in 148 patients after CABG for median of 5...
March 28, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28209301/iswi-atp-dependent-remodeling-of-nucleoplasmic-%C3%AF-speckles-in-the-brain-of-drosophila-melanogaster
#7
Luca Lo Piccolo, Andrea Attardi, Rosa Bonaccorso, Lorenzo Li Greci, Giorgio Giurato, Antonia Maria Rita Ingrassia, Maria Cristina Onorati
Heterogeneous nuclear ribonucleoproteins (hnRNPs) belong to the RNA-binding proteins family. They are involved in processing heterogeneous nuclear RNAs (hnRNAs) into mature mRNAs. These proteins participate in every step of mRNA cycle, such as mRNA export, localization, translation, stability and alternative splicing. At least 14 major hnRNPs, which have structural and functional homologues in mammals, are expressed in Drosophila melanogaster. Until now, six of these hnRNPs are known to be nucleus-localized and associated with the long non-coding RNA (lncRNA) heat shock responsive ω (hsrω) in the omega speckle compartments (ω-speckles)...
February 20, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28204140/impact-of-failed-mitral-valve-repair-on-hospital-outcome-of-redo-mitral-valve-procedures
#8
Francesco Onorati, Giuseppe Gatti, Andrea Perrotti, Giovanni Mariscalco, Daniel Reichart, Aldo Milano, Ester Della Ratta, Antonio Rubino, Giuseppe Santarpino, Antonio Salsano, Fausto Biancari, Christian Detter, Sidney Chocron, Cesare Beghi, Marisa De Feo, Carmelo Mignosa, Theodor Fischlein, Aniello Pappalardo, Paola D'Errigo, Francesco Santini, Giuseppe Faggian
OBJECTIVES: The prognostic impact of failed mitral valve repair (FMR) on in-hospital outcome after redo mitral valve surgery has not been thoroughly investigated. METHODS: Hospital outcomes after redo mitral valve surgery because of an FMR in patients from nine European centres were reported. Logistic regressions identified predictors of mortality in combined or isolated redo mitral valve operations. Hospital outcome was compared between propensity-matched cohorts with FMR and native mitral valves in the context of redo surgery and FMR versus failed prostheses...
May 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28198053/morphology-quiz-cytopathology-of-a-thyroid-neoplasm
#9
M Nicola, M Onorati, S Bellone, P Collini, F Di Nuovo
No abstract text is available yet for this article.
February 14, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28024656/validation-of-bleeding-classifications-in-coronary-artery-bypass-grafting
#10
Debora Brascia, Daniel Reichart, Francesco Onorati, Andrea Perrotti, Vito G Ruggieri, Karl Bounader, Jean Philippe Verhoye, Giuseppe Santarpino, Theodor Fischlein, Daniele Maselli, Carmelo Dominici, Giovanni Mariscalco, Riccardo Gherli, Antonino S Rubino, Marisa De Feo, Ciro Bancone, Giuseppe Gatti, Francesco Santini, Magnus Dalén, Matteo Saccocci, Giuseppe Faggian, Tuomas Tauriainen, Eeva-Maija Kinnunen, Francesco Nicolini, Tiziano Gherli, Stefano Rosato, Fausto Biancari
Perioperative bleeding is a determinant of poor outcome in patients undergoing coronary artery bypass grafting (CABG), but there is a lack of adequate stratification of its severity. The ability of the European registry of Coronary Artery Bypass Grafting (E-CABG), Universal Definition of Perioperative Bleeding (UDPB), Study of Platelet Inhibition and Patient Outcomes (PLATO), Clopidogrel and Aspirin Optimal Dose Usage to Reduce Recurrent Events-Seventh Organization to Assess Strategies in Ischemic Syndromes (CURRENT-OASIS 7), Efficacy and Safety of Subcutaneous Enoxaparin in Non-Q Wave Coronary Events (ESSENCE), and SafeTy and Efficacy of Enoxaparin in Percutaneous coronary intervention patients, an internationaL randomized Evaluation (STEEPLE) bleeding classifications to predict early mortality, stroke, acute kidney injury (AKI) stage 3, and deep sternal wound infection/mediastinitis was investigated in 3,730 patients from the prospective, multicentre E-CABG registry...
March 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/27942414/lung-cancer-in-elderly-patients
#11
REVIEW
Federico Venuta, Daniele Diso, Ilaria Onorati, Marco Anile, Sara Mantovani, Erino A Rendina
There is a worldwide-accepted evidence of a population shift toward older ages. This shift favors an increased risk of developing lung cancer that is primarily a disease of older populations. Decision making is extremely difficult in elderly patients, since this group is under-represented in clinical trials with only 25% of them historically opening to patients older than 65 years. For all these reasons, a "customized" preoperative assessment to identify physiological or pathological frailty should be encouraged since standard tools may be less reliable...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27928145/glycated-hemoglobin-and-risk-of-sternal-wound-infection-after-isolated-coronary-surgery
#12
MULTICENTER STUDY
Giuseppe Gatti, Andrea Perrotti, Daniel Reichart, Luca Maschietto, Francesco Onorati, Sidney Chocron, Magnus Dalén, Peter Svenarud, Giuseppe Faggian, Giuseppe Santarpino, Theodor Fischlein, Aniello Pappalardo, Daniele Maselli, Carmelo Dominici, Saverio Nardella, Antonino S Rubino, Marisa De Feo, Francesco Santini, Francesco Nicolini, Riccardo Gherli, Giovanni Mariscalco, Tuomas Tauriainen, Eeva-Maija Kinnunen, Vito G Ruggieri, Matteo Saccocci, Fausto Biancari
BACKGROUND: Glycated hemoglobin (HbA1c) is a suspected risk factor for sternal wound infection (SWI) after CABG.Methods and Results:Data on preoperative HbA1c and SWI were available in 2,130 patients undergoing isolated CABG from the prospective E-CABG registry. SWI occurred in 114 (5.4%). Baseline HbA1c was significantly higher in patients with SWI (mean, 54±17 vs. 45±13 mmol/mol, P<0.0001). This difference was also observed in patients without a diagnosis of diabetes (P=0.027), in insulin-dependent diabetic (P=0...
December 22, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27904903/prediction-of-severe-bleeding-after-coronary-surgery-the-will-bleed-risk-score
#13
Fausto Biancari, Debora Brascia, Francesco Onorati, Daniel Reichart, Andrea Perrotti, Vito G Ruggieri, Giuseppe Santarpino, Daniele Maselli, Giovanni Mariscalco, Riccardo Gherli, Antonino S Rubino, Marisa De Feo, Giuseppe Gatti, Francesco Santini, Magnus Dalén, Matteo Saccocci, Eeva-Maija Kinnunen, Juhani K E Airaksinen, Paola D'Errigo, Stefano Rosato, Francesco Nicolini
Severe perioperative bleeding after coronary artery bypass grafting (CABG) is associated with poor outcome. An additive score for prediction of severe bleeding was derived (n=2494) and validated (n=1250) in patients from the E-CABG registry. Severe bleeding was defined as E-CABG bleeding grades 2-3 (transfusion of >4 units of red blood cells or reoperation for bleeding). The overall incidence of severe bleeding was 6.4 %. Preoperative anaemia (3 points), female gender (2 points), eGFR <45 ml/min/1.73 m(2) (3 points), potent antiplatelet drugs discontinued less than five days (2 points), critical preoperative state (5 points), acute coronary syndrome (2 points), use of low-molecular-weight heparin/fondaparinux/unfractionated heparin (1 point) were independent predictors of severe bleeding...
February 28, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/27899243/corrigendum-to-brain-and-cognitive-functions-in-two-groups-of-na%C3%A3-ve-hiv-patients-selected-for-a-different-plan-of-antiretroviral-therapy-a-qeeg-study-clin-neurophysiol-127-2016-3455-3469
#14
Claudio Babiloni, Alfredo Pennica, Paolo Capotosto, Paolo Onorati, Chiara Muratori, Stefano Ferracuti, Paolo Roma, Valentina Correr, Elisa Piccinni, Giuseppe Noce, Claudio Del Percio, Susanna Cordone, Cristina Limatola, Andrea Soricelli, Francesco Di Campli, Laura Gianserra, Lorenzo Ciullini, Antonio Aceti, Magdalena Viscione, Elisabetta Teti, Loredana Sarmati, Massimo Andreoni
No abstract text is available yet for this article.
January 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/27884542/corrigendum-to-abnormal-cortical-sources-of-resting-state-electroencephalographic-rhythms-in-single-treatment-na%C3%A3-ve-hiv-individuals-a-statistical-z-score-index-clin-neurophysiol-127-2016-1803-1812
#15
Claudio Babiloni, Alfredo Pennica, Claudio Del Percio, Giuseppe Noce, Susanna Cordone, Chiara Muratori, Stefano Ferracuti, Nicole Donato, Francesco Di Campli, Laura Gianserra, Elisabetta Teti, Antonio Aceti, Andrea Soricelli, Magdalena Viscione, Cristina Limatola, Massimo Andreoni, Paolo Onorati
No abstract text is available yet for this article.
January 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/27865321/chest-tubes-generalities
#16
REVIEW
Federico Venuta, Daniele Diso, Marco Anile, Erino A Rendina, Ilaria Onorati
Insertion, management, and withdrawal of chest tubes is part of the routine activity of thoracic surgeons. The selection of the chest tube and the strategy for each of these steps is usually built on knowledge, practice, experience, and judgment. The indication to insert a chest tube into the pleural cavity is the presence of air or fluid within it. Various types and sizes of chest tubes are now commercially available.
February 2017: Thoracic Surgery Clinics
https://www.readbyqxmd.com/read/27795924/giving-meaning-to-tweets-in-emergency-situations-a-semantic-approach-for-filtering-and-visualizing-social-data
#17
Teresa Onorati, Paloma Díaz
In this paper, we propose a semantic approach for monitoring information published on social networks about a specific event. In the era of Big Data, when an emergency occurs information posted on social networks becomes more and more helpful for emergency operators. As direct witnesses of the situation, people share photos, videos or text messages about events that call their attention. In the emergency operation center, these data can be collected and integrated within the management process to improve the overall understanding of the situation and in particular of the citizen reactions...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27774615/incidence-and-prognostic-impact-of-bleeding-and-transfusion-after-coronary-surgery-in-low-risk-patients
#18
MULTICENTER STUDY
Eeva-Maija Kinnunen, Marisa De Feo, Daniel Reichart, Tuomas Tauriainen, Giuseppe Gatti, Francesco Onorati, Luca Maschietto, Ciro Bancone, Francesca Fiorentino, Sidney Chocron, Karl Bounader, Magnus Dalén, Peter Svenarud, Giuseppe Faggian, Ilaria Franzese, Giuseppe Santarpino, Theodor Fischlein, Daniele Maselli, Carmelo Dominici, Saverio Nardella, Riccardo Gherli, Francesco Musumeci, Antonino S Rubino, Carmelo Mignosa, Giovanni Mariscalco, Filiberto G Serraino, Francesco Santini, Antonio Salsano, Francesco Nicolini, Tiziano Gherli, Marco Zanobini, Matteo Saccocci, Vito G Ruggieri, Jean Philippe Verhoye, Andrea Perrotti, Fausto Biancari
BACKGROUND: Excessive bleeding and blood transfusion are associated with adverse outcome after cardiac surgery, but their mechanistic effects are difficult to disentangle in patients with increased operative risk. This study aimed to evaluate the incidence and prognostic impact of bleeding and transfusion of blood products in low-risk patients undergoing coronary artery bypass grafting (CABG). STUDY DESIGN AND METHODS: Sixteen tertiary European centers of cardiac surgery contributed to the prospective European registry of CABG (E-CABG)...
January 2017: Transfusion
https://www.readbyqxmd.com/read/27716535/brain-and-cognitive-functions-in-two-groups-of-na%C3%A3-ve-hiv-patients-selected-for-a-different-plan-of-antiretroviral-therapy-a-qeeg-study
#19
Claudio Babiloni, Alfredo Pennica, Paolo Capotosto, Paolo Onorati, Chiara Muratori, Stefano Ferracuti, Paolo Roma, Valentina Correr, Elisa Piccinni, Giuseppe Noce, Claudio Del Percio, Susanna Cordone, Cristina Limatola, Andrea Soricelli, Francesco Di Campli, Laura Gianserra, Lorenzo Ciullini, Antonio Aceti, Magdalena Viscione, Elisabetta Teti, Loredana Sarmati, Massimo Andreoni
OBJECTIVE: Cortical sources of electroencephalographic (EEG) rhythms were investigated in two sub-populations of naïve HIV subjects, grouped based on clinical criteria to receive different combination anti-retroviral therapies (cARTs). These EEG sources were hypothesized to reflect beneficial effects of both regimes. METHODS: Eyes-closed resting state EEG data were collected in 19 (Group A) and 39 (Group B) naïve HIV subjects at baseline (i.e. pre-treatment; T0) and after 5months of cART (T5)...
November 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/27568284/zika-virus-disrupts-phospho-tbk1-localization-and-mitosis-in-human-neuroepithelial-stem-cells-and-radial-glia
#20
Marco Onorati, Zhen Li, Fuchen Liu, André M M Sousa, Naoki Nakagawa, Mingfeng Li, Maria Teresa Dell'Anno, Forrest O Gulden, Sirisha Pochareddy, Andrew T N Tebbenkamp, Wenqi Han, Mihovil Pletikos, Tianliuyun Gao, Ying Zhu, Candace Bichsel, Luis Varela, Klara Szigeti-Buck, Steven Lisgo, Yalan Zhang, Anze Testen, Xiao-Bing Gao, Jernej Mlakar, Mara Popovic, Marie Flamand, Stephen M Strittmatter, Leonard K Kaczmarek, E S Anton, Tamas L Horvath, Brett D Lindenbach, Nenad Sestan
The mechanisms underlying Zika virus (ZIKV)-related microcephaly and other neurodevelopment defects remain poorly understood. Here, we describe the derivation and characterization, including single-cell RNA-seq, of neocortical and spinal cord neuroepithelial stem (NES) cells to model early human neurodevelopment and ZIKV-related neuropathogenesis. By analyzing human NES cells, organotypic fetal brain slices, and a ZIKV-infected micrencephalic brain, we show that ZIKV infects both neocortical and spinal NES cells as well as their fetal homolog, radial glial cells (RGCs), causing disrupted mitoses, supernumerary centrosomes, structural disorganization, and cell death...
September 6, 2016: Cell Reports
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