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https://www.readbyqxmd.com/read/28024656/validation-of-bleeding-classifications-in-coronary-artery-bypass-grafting
#1
Debora Brascia, Daniel Reichart, Francesco Onorati, Andrea Perrotti, Vito G Ruggieri, Karl Bounader, Jean Philippe Verhoye, Giuseppe Santarpino, Theodor Fischlein, Daniele Maselli, Carmelo Dominici, Giovanni Mariscalco, Riccardo Gherli, Antonino S Rubino, Marisa De Feo, Ciro Bancone, Giuseppe Gatti, Francesco Santini, Magnus Dalén, Matteo Saccocci, Giuseppe Faggian, Tuomas Tauriainen, Eeva-Maija Kinnunen, Francesco Nicolini, Tiziano Gherli, Stefano Rosato, Fausto Biancari
Perioperative bleeding is a determinant of poor outcome in patients undergoing coronary artery bypass grafting (CABG), but there is a lack of adequate stratification of its severity. The ability of the European registry of Coronary Artery Bypass Grafting (E-CABG), Universal Definition of Perioperative Bleeding (UDPB), Study of Platelet Inhibition and Patient Outcomes (PLATO), Clopidogrel and Aspirin Optimal Dose Usage to Reduce Recurrent Events-Seventh Organization to Assess Strategies in Ischemic Syndromes (CURRENT-OASIS 7), Efficacy and Safety of Subcutaneous Enoxaparin in Non-Q Wave Coronary Events (ESSENCE), and SafeTy and Efficacy of Enoxaparin in Percutaneous coronary intervention patients, an internationaL randomized Evaluation (STEEPLE) bleeding classifications to predict early mortality, stroke, acute kidney injury (AKI) stage 3, and deep sternal wound infection/mediastinitis was investigated in 3,730 patients from the prospective, multicentre E-CABG registry...
December 3, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27942414/lung-cancer-in-elderly-patients
#2
REVIEW
Federico Venuta, Daniele Diso, Ilaria Onorati, Marco Anile, Sara Mantovani, Erino A Rendina
There is a worldwide-accepted evidence of a population shift toward older ages. This shift favors an increased risk of developing lung cancer that is primarily a disease of older populations. Decision making is extremely difficult in elderly patients, since this group is under-represented in clinical trials with only 25% of them historically opening to patients older than 65 years. For all these reasons, a "customized" preoperative assessment to identify physiological or pathological frailty should be encouraged since standard tools may be less reliable...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27928145/glycated-hemoglobin-and-risk-of-sternal-wound-infection-after-isolated-coronary-surgery
#3
Giuseppe Gatti, Andrea Perrotti, Daniel Reichart, Luca Maschietto, Francesco Onorati, Sidney Chocron, Magnus Dalén, Peter Svenarud, Giuseppe Faggian, Giuseppe Santarpino, Theodor Fischlein, Aniello Pappalardo, Daniele Maselli, Carmelo Dominici, Saverio Nardella, Antonino S Rubino, Marisa De Feo, Francesco Santini, Francesco Nicolini, Riccardo Gherli, Giovanni Mariscalco, Tuomas Tauriainen, Eeva-Maija Kinnunen, Vito G Ruggieri, Matteo Saccocci, Fausto Biancari
BACKGROUND: Glycated hemoglobin (HbA1c) is a suspected risk factor for sternal wound infection (SWI) after CABG.Methods and Results:Data on preoperative HbA1c and SWI were available in 2,130 patients undergoing isolated CABG from the prospective E-CABG registry. SWI occurred in 114 (5.4%). Baseline HbA1c was significantly higher in patients with SWI (mean, 54±17 vs. 45±13 mmol/mol, P<0.0001). This difference was also observed in patients without a diagnosis of diabetes (P=0.027), in insulin-dependent diabetic (P=0...
December 22, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/27904903/prediction-of-severe-bleeding-after-coronary-surgery-the-will-bleed-risk-score
#4
Fausto Biancari, Debora Brascia, Francesco Onorati, Daniel Reichart, Andrea Perrotti, Vito G Ruggieri, Giuseppe Santarpino, Daniele Maselli, Giovanni Mariscalco, Riccardo Gherli, Antonino S Rubino, Marisa De Feo, Giuseppe Gatti, Francesco Santini, Magnus Dalén, Matteo Saccocci, Eeva-Maija Kinnunen, Juhani K E Airaksinen, Paola D'Errigo, Stefano Rosato, Francesco Nicolini
Severe perioperative bleeding after coronary artery bypass grafting (CABG) is associated with poor outcome. An additive score for prediction of severe bleeding was derived (n=2494) and validated (n=1250) in patients from the E-CABG registry. Severe bleeding was defined as E-CABG bleeding grades 2-3 (transfusion of >4 units of red blood cells or reoperation for bleeding). The overall incidence of severe bleeding was 6.4 %. Preoperative anaemia (3 points), female gender (2 points), eGFR <45 ml/min/1.73 m(2) (3 points), potent antiplatelet drugs discontinued less than five days (2 points), critical preoperative state (5 points), acute coronary syndrome (2 points), use of low-molecular-weight heparin/fondaparinux/unfractionated heparin (1 point) were independent predictors of severe bleeding...
December 1, 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/27899243/corrigendum-to-brain-and-cognitive-functions-in-two-groups-of-na%C3%A3-ve-hiv-patients-selected-for-a-different-plan-of-antiretroviral-therapy-a-qeeg-study-clin-neurophysiol-127-2016-3455-3469
#5
Claudio Babiloni, Alfredo Pennica, Paolo Capotosto, Paolo Onorati, Chiara Muratori, Stefano Ferracuti, Paolo Roma, Valentina Correr, Elisa Piccinni, Giuseppe Noce, Claudio Del Percio, Susanna Cordone, Cristina Limatola, Andrea Soricelli, Francesco Di Campli, Laura Gianserra, Lorenzo Ciullini, Antonio Aceti, Magdalena Viscione, Elisabetta Teti, Loredana Sarmati, Massimo Andreoni
No abstract text is available yet for this article.
January 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/27884542/corrigendum-to-abnormal-cortical-sources-of-resting-state-electroencephalographic-rhythms-in-single-treatment-na%C3%A3-ve-hiv-individuals-a-statistical-z-score-index-clin-neurophysiol-127-2016-1803-1812
#6
Claudio Babiloni, Alfredo Pennica, Claudio Del Percio, Giuseppe Noce, Susanna Cordone, Chiara Muratori, Stefano Ferracuti, Nicole Donato, Francesco Di Campli, Laura Gianserra, Elisabetta Teti, Antonio Aceti, Andrea Soricelli, Magdalena Viscione, Cristina Limatola, Massimo Andreoni, Paolo Onorati
No abstract text is available yet for this article.
January 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/27865321/chest-tubes-generalities
#7
REVIEW
Federico Venuta, Daniele Diso, Marco Anile, Erino A Rendina, Ilaria Onorati
Insertion, management, and withdrawal of chest tubes is part of the routine activity of thoracic surgeons. The selection of the chest tube and the strategy for each of these steps is usually built on knowledge, practice, experience, and judgment. The indication to insert a chest tube into the pleural cavity is the presence of air or fluid within it. Various types and sizes of chest tubes are now commercially available.
February 2017: Thoracic Surgery Clinics
https://www.readbyqxmd.com/read/27795924/giving-meaning-to-tweets-in-emergency-situations-a-semantic-approach-for-filtering-and-visualizing-social-data
#8
Teresa Onorati, Paloma Díaz
In this paper, we propose a semantic approach for monitoring information published on social networks about a specific event. In the era of Big Data, when an emergency occurs information posted on social networks becomes more and more helpful for emergency operators. As direct witnesses of the situation, people share photos, videos or text messages about events that call their attention. In the emergency operation center, these data can be collected and integrated within the management process to improve the overall understanding of the situation and in particular of the citizen reactions...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27774615/incidence-and-prognostic-impact-of-bleeding-and-transfusion-after-coronary-surgery-in-low-risk-patients
#9
Eeva-Maija Kinnunen, Marisa De Feo, Daniel Reichart, Tuomas Tauriainen, Giuseppe Gatti, Francesco Onorati, Luca Maschietto, Ciro Bancone, Francesca Fiorentino, Sidney Chocron, Karl Bounader, Magnus Dalén, Peter Svenarud, Giuseppe Faggian, Ilaria Franzese, Giuseppe Santarpino, Theodor Fischlein, Daniele Maselli, Carmelo Dominici, Saverio Nardella, Riccardo Gherli, Francesco Musumeci, Antonino S Rubino, Carmelo Mignosa, Giovanni Mariscalco, Filiberto G Serraino, Francesco Santini, Antonio Salsano, Francesco Nicolini, Tiziano Gherli, Marco Zanobini, Matteo Saccocci, Vito G Ruggieri, Jean Philippe Verhoye, Andrea Perrotti, Fausto Biancari
BACKGROUND: Excessive bleeding and blood transfusion are associated with adverse outcome after cardiac surgery, but their mechanistic effects are difficult to disentangle in patients with increased operative risk. This study aimed to evaluate the incidence and prognostic impact of bleeding and transfusion of blood products in low-risk patients undergoing coronary artery bypass grafting (CABG). STUDY DESIGN AND METHODS: Sixteen tertiary European centers of cardiac surgery contributed to the prospective European registry of CABG (E-CABG)...
October 23, 2016: Transfusion
https://www.readbyqxmd.com/read/27716535/brain-and-cognitive-functions-in-two-groups-of-na%C3%A3-ve-hiv-patients-selected-for-a-different-plan-of-antiretroviral-therapy-a-qeeg-study
#10
Claudio Babiloni, Alfredo Pennica, Paolo Capotosto, Paolo Onorati, Chiara Muratori, Stefano Ferracuti, Paolo Roma, Valentina Correr, Elisa Piccinni, Giuseppe Noce, Claudio Del Percio, Susanna Cordone, Cristina Limatola, Andrea Soricelli, Francesco Di Campli, Laura Gianserra, Lorenzo Ciullini, Antonio Aceti, Magdalena Viscione, Elisabetta Teti, Loredana Sarmati, Massimo Andreoni
OBJECTIVE: Cortical sources of electroencephalographic (EEG) rhythms were investigated in two sub-populations of naïve HIV subjects, grouped based on clinical criteria to receive different combination anti-retroviral therapies (cARTs). These EEG sources were hypothesized to reflect beneficial effects of both regimes. METHODS: Eyes-closed resting state EEG data were collected in 19 (Group A) and 39 (Group B) naïve HIV subjects at baseline (i.e. pre-treatment; T0) and after 5months of cART (T5)...
September 9, 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/27568284/zika-virus-disrupts-phospho-tbk1-localization-and-mitosis-in-human-neuroepithelial-stem-cells-and-radial-glia
#11
Marco Onorati, Zhen Li, Fuchen Liu, André M M Sousa, Naoki Nakagawa, Mingfeng Li, Maria Teresa Dell'Anno, Forrest O Gulden, Sirisha Pochareddy, Andrew T N Tebbenkamp, Wenqi Han, Mihovil Pletikos, Tianliuyun Gao, Ying Zhu, Candace Bichsel, Luis Varela, Klara Szigeti-Buck, Steven Lisgo, Yalan Zhang, Anze Testen, Xiao-Bing Gao, Jernej Mlakar, Mara Popovic, Marie Flamand, Stephen M Strittmatter, Leonard K Kaczmarek, E S Anton, Tamas L Horvath, Brett D Lindenbach, Nenad Sestan
The mechanisms underlying Zika virus (ZIKV)-related microcephaly and other neurodevelopment defects remain poorly understood. Here, we describe the derivation and characterization, including single-cell RNA-seq, of neocortical and spinal cord neuroepithelial stem (NES) cells to model early human neurodevelopment and ZIKV-related neuropathogenesis. By analyzing human NES cells, organotypic fetal brain slices, and a ZIKV-infected micrencephalic brain, we show that ZIKV infects both neocortical and spinal NES cells as well as their fetal homolog, radial glial cells (RGCs), causing disrupted mitoses, supernumerary centrosomes, structural disorganization, and cell death...
September 6, 2016: Cell Reports
https://www.readbyqxmd.com/read/27541360/functional-mitral-regurgitation-are-we-treating-the-real-target
#12
Giovanni Benfari, Rajesh Dandale, Andrea Rossi, Francesco Onorati, Giacomo Mugnai, Flavio Ribichini, Pier L Temporelli, Corrado Vassanelli
Functional mitral regurgitation is a form of valve insufficiency in the presence of anatomically normal mitral valve. The cause of functional mitral regurgitation is left ventricular remodelling that tethers valve leaflet more apically decreasing their coaptation ability. Given the pathophysiologic relation between functional mitral regurgitation and ventricular dysfunction, the valve insufficiency has long been considered a surrogate of ventricular disease. Accordingly, all potential therapeutic strategies able to decrease functional mitral regurgitation have been associated with improved ventricular function...
November 2016: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/27495961/outcome-after-general-anesthesia-versus-monitored-anesthesia-care-in-transfemoral-transcatheter-aortic-valve-replacement
#13
Paola D'Errigo, Marco Ranucci, Remo Daniel Covello, Fausto Biancari, Stefano Rosato, Marco Barbanti, Francesco Onorati, Corrado Tamburino, Gennaro Santoro, Claudio Grossi, Francesco Santini, Katia Bontempi, Danilo Fusco, Fulvia Seccareccia
OBJECTIVE: To evaluate outcomes of monitored anesthesia care (MAC) compared with general anesthesia (GA) in patients undergoing transfemoral transcatheter aortic valve replacement (TAVR). DESIGN: Secondary analysis from the observational and prospective OBSERVANT (OBservational Study of Effectiveness of avR-taVi procedures for severe Aortic steNosis Treatment) study. SETTING: Multicenter study, including Italian hospitals performing TAVR interventions...
October 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/27449407/plasma-concentrations-of-progesterone-and-estradiol-and-the-relation-to-reproduction-in-gal%C3%A3-pagos-land-iguanas-conolophus-marthae-and-c-subcristatus-squamata-iguanidae
#14
Michela Onorati, Giulia Sancesario, Donatella Pastore, Sergio Bernardini, Jorge E Carrión, Monica Carosi, Leonardo Vignoli, Davide Lauro, Gabriele Gentile
In a combined approach, endocrine and ultrasonic analyses were performed to assess reproduction of two syntopic populations of terrestrial Galápagos iguanas the Conolophus marthae (the Galápagos Pink Land Iguana) and C. subcristatus on the Volcán Wolf (Isabela Island). The ELISA methods (enzyme-linked immunosorbent assay) were used to measure plasma concentrations of progesterone (P4) and 17β-estradiol (E2) from samples collected over the course of three different seasons: July 2010, June 2012-2014. As for C...
September 2016: Animal Reproduction Science
https://www.readbyqxmd.com/read/27408799/antiretroviral-therapy-affects-the-z-score-index-of-deviant-cortical-eeg-rhythms-in-na%C3%A3-ve-hiv-individuals
#15
Claudio Babiloni, Alfredo Pennica, Claudio Del Percio, Giuseppe Noce, Susanna Cordone, Susanna Lopez, Ketura Berry, Chiara Muratori, Stefano Ferracuti, Paolo Roma, Valentina Correr, Francesco Di Campli, Laura Gianserra, Lorenzo Ciullini, Antonio Aceti, Andrea Soricelli, Elisabetta Teti, Magdalena Viscione, Cristina Limatola, Paolo Onorati, Paolo Capotosto, Massimo Andreoni
OBJECTIVE: Here we tested the effect of combined antiretroviral therapy (cART) on deviant electroencephalographic (EEG) source activity in treatment-naïve HIV individuals. METHODS: Resting state eyes-closed EEG data were recorded before and after 5 months of cART in 48 male HIV subjects, who were naïve at the study start. The EEG data were also recorded in 59 age- and sex-matched healthy subjects as a control group. Frequency bands of interest included delta, theta, alpha1, alpha2 and alpha3, based on alpha frequency peak specific to each individual...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27405607/erratum-to-preservation-of-positional-identity-in-fetus-derived-neural-stem-ns-cells-from-different-mouse-central-nervous-system-compartments
#16
Marco Onorati, Maurizio Binetti, Luciano Conti, Stefano Camnasio, Giovanna Calabrese, Ilaria Albieri, Francesca Di Febo, Mauro Toselli, Gerardo Biella, Ben Martynoga, Francois Guillemot, G Giacomo Consalez, Elena Cattaneo
No abstract text is available yet for this article.
July 12, 2016: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/27343820/bleeding-transfusion-and-the-risk-of-stroke-after-coronary-surgery-a-prospective-cohort-study-of-2357-patients
#17
Fausto Biancari, Tuomas Tauriainen, Andrea Perrotti, Magnus Dalén, Giuseppe Faggian, Ilaria Franzese, Sidney Chocron, Vito G Ruggieri, Karl Bounader, Helmut Gulbins, Daniel Reichart, Peter Svenarud, Giuseppe Santarpino, Theodor Fischlein, Tamas Puski, Daniele Maselli, Carmelo Dominici, Saverio Nardella, Giovanni Mariscalco, Riccardo Gherli, Francesco Musumeci, Antonino S Rubino, Carmelo Mignosa, Marisa De Feo, Ciro Bancone, Giuseppe Gatti, Luca Maschietto, Francesco Santini, Antonio Salsano, Francesco Nicolini, Tiziano Gherli, Marco Zanobini, Matteo Saccocci, Paola D'Errigo, Eeva-Maija Kinnunen, Francesco Onorati
INTRODUCTION: This study was planned to investigate the impact of severe bleeding and blood transfusion on the development of stroke after coronary surgery. METHODS: This cohort study includes 2357 patients undergoing isolated CABG from the prospective European Coronary Artery Bypass Grafting (E-CABG) registry. Severity of bleeding was categorized according to the Universal Definition of Perioperative Bleeding (UDPB), E-CABG and PLATO definitions. RESULTS: Thirty patients (1...
August 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27197962/outcome-of-jehovah-s-witnesses-after-adult-cardiac-surgery-systematic-review-and-meta-analysis-of-comparative-studies
#18
REVIEW
Francesco Vasques, Eeva-Maija Kinnunen, Marek Pol, Giovanni Mariscalco, Francesco Onorati, Fausto Biancari
BACKGROUND: The objective was to evaluate the early outcome after adult cardiac surgery in Jehovah's Witnesses (JWs) compared with controls not refusing blood transfusions. STUDY DESIGN AND METHODS: A literature review was performed through PubMed, Scopus, and Google Scholar to identify any comparative study evaluating the outcome of JWs and patients not refusing blood transfusion after adult cardiac surgery. RESULTS: Six studies comparing the outcome of 564 JWs and 903 controls fulfilled the inclusion criteria of this study...
August 2016: Transfusion
https://www.readbyqxmd.com/read/27154298/transcatheter-aortic-valve-implantation-compared-with-surgical-aortic-valve-replacement-in-low-risk-patients
#19
MULTICENTER STUDY
Stefano Rosato, Francesco Santini, Marco Barbanti, Fausto Biancari, Paola D'Errigo, Francesco Onorati, Corrado Tamburino, Marco Ranucci, Remo Daniel Covello, Gennaro Santoro, Claudio Grossi, Martina Ventura, Danilo Fusco, Fulvia Seccareccia
BACKGROUND: The proven efficacy of transcatheter aortic valve implantation (TAVI) in high-risk patients is leading to the expansion of its indications toward lower-risk patients. However, this shift is not supported by meaningful evidence of its benefit over surgical aortic valve replacement (SAVR). This analysis aims to describe outcomes of TAVI versus SAVR in low-risk patients. METHODS AND RESULTS: We compared the outcome after TAVI and SAVR of low-risk patients (European System for Cardiac Operative Risk Evaluation II [EuroSCORE II] <4%) included in the Observational Study of Effectiveness of SAVR-TAVI Procedures for Severe Aortic Stenosis Treatment (OBSERVANT) study...
May 2016: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/27135218/surviving-a-childhood-cancer-impact-on-education-and-employment
#20
Milena Maule, Daniela Zugna, Enrica Migliore, Daniela Alessi, Franco Merletti, Roberta Onorati, Nicolás Zengarini, Giuseppe Costa, Teresa Spadea
Long-term consequences of childhood cancer encompass adverse psychosocial effects that may severely limit the opportunity to live a satisfying and productive life. We assessed the social integration of adults cured of a cancer in their first 14 years of life by record linkage between the population-based Childhood Cancer Registry of Piedmont and the Turin Longitudinal Study. We compared education and employment outcomes within the cohort of survivors and between the cohort of survivors and their peers in the general population through logistic regression...
April 29, 2016: European Journal of Cancer Prevention
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