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Flushing in adults

J Salvaing, N Peynot, M N Bedhane, S Veniel, E Pellier, C Boulesteix, N Beaujean, N Daniel, V Duranthon
STUDY QUESTION: In comparison to in vivo development, how do different conditions of in vitro culture ('one step' versus 'sequential medium') impact DNA methylation and hydroxymethylation in preimplantation embryos? SUMMARY ANSWER: Using rabbit as a model, we show that DNA methylation and hydroxymethylation are both affected by in vitro culture of preimplantation embryos and the effect observed depends on the culture medium used. WHAT IS KNOWN ALREADY: Correct regulation of DNA methylation is essential for embryonic development and DNA hydroxymethylation appears more and more to be a key player...
September 22, 2016: Human Reproduction
Philip R Cohen
BACKGROUND: Mastocytosis is either cutaneous (with skin-limited proliferation of mast cells) or systemic (with mast cells in extracutaneous sites). The onset of solitary mastocytoma in an adult is rare. PURPOSE: A woman with the new onset of solitary mastocytoma is described. The clinical features of patients with adult-onset solitary mastocytoma are summarized. Recommendations for the evaluation and treatment of individuals with adult-onset solitary mastocytoma are proposed...
July 2016: Dermatology Practical & Conceptual
Irene Bighelli, Carlotta Trespidi, Mariasole Castellazzi, Andrea Cipriani, Toshi A Furukawa, Francesca Girlanda, Giuseppe Guaiana, Markus Koesters, Corrado Barbui
BACKGROUND: A panic attack is a discrete period of fear or anxiety that has a rapid onset, reaches a peak within 10 minutes and in which at least four of 13 characteristic symptoms are experienced, including racing heart, chest pain, sweating, shaking, dizziness, flushing, stomach churning, faintness and breathlessness. Panic disorder is common in the general population with a lifetime prevalence of 1% to 4%. The treatment of panic disorder includes psychological and pharmacological interventions...
September 12, 2016: Cochrane Database of Systematic Reviews
Paul Wicks, Lawrence Rasouliyan, Bo Katic, Beenish Nafees, Emuella Flood, Rahul Sasané
BACKGROUND: Oral disease-modifying therapies offer equivalent or superior efficacy and greater convenience versus injectable options. OBJECTIVES: To compare patient-reported experiences of fingolimod and dimethyl fumarate. METHODS: Adult relapsing-remitting multiple sclerosis patients treated with fingolimod or dimethyl fumarate were recruited from an online patient community and completed an online survey about treatment side effects, discontinuation, and satisfaction...
2016: BMC Research Notes
Di Wu, Jian Chen, Bincheng Wang, Mo Zhang, Jingfei Shi, Yanhui Ma, Zixin Zhu, Feng Yan, Xiaoduo He, Shengli Li, David Dornbos Iii, Yuchuan Ding, Xunming Ji
To further investigate and improve upon current stroke models in nonhuman primates, infarct size, neurologic function and survival were evaluated in two endovascular ischemic models in sixteen rhesus monkeys. The first method utilized a micro-catheter or an inflatable balloon to occlude the M1 segment in six monkeys. In the second model, an autologous clot was injected via a micro-catheter into the M1 segment in ten monkeys. MRI scanning was performed on all monkeys both at baseline and 3 hours after the onset of ischemia...
2016: Scientific Reports
Mauro Pittiruti, Sergio Bertoglio, Giancarlo Scoppettuolo, Roberto Biffi, Massimo Lamperti, Alberto Dal Molin, Nicola Panocchia, Nicola Petrosillo, Mario Venditti, Carla Rigo, Enrico DeLutio
BACKGROUND: The most appropriate lock solution for central venous access devices is still to be defined. GAVeCeLT - the Italian group for venous access devices - has developed a consensus on the evidence-based criteria for the choice and the clinical use of the most appropriate lock solution for central venous catheters (excluding dialysis catheters). METHOD: After the constitution of a panel of experts, a systematic collection and review of the literature has been performed, focusing on clinical studies dealing with lock solutions used for prevention of occlusion (heparin, citrate, urokinase, recombinant tissue plasminogen activator [r-TPA], normal saline) or for prevention of infection (citrate, ethanol, taurolidine, ethylene-diamine-tetra-acetic acid [EDTA], vancomycin, linezolid and other antibiotics), in both adults and in pediatric patients...
August 1, 2016: Journal of Vascular Access
Perrine Benmansour, Jennifer Billinsky, Tanya Duke-Novakovski, Jane Alcorn
OBJECTIVE: To determine blood remifentanil concentration in isoflurane-anesthetized horses during and after a 1h remifentanil and dexmedetomidine infusion. STUDY DESIGN: Prospective study. ANIMALS: Six adult mixed breed horses with (mean±SD) bodyweight of 507±61kg and 14±4years of age. METHODS: Following sedation with xylazine IV, anesthesia was induced with ketamine IV mixed with diazepam IV. Anesthesia was maintained with isoflurane in oxygen...
August 2016: Research in Veterinary Science
Samantha Keogh, Julie Flynn, Nicole Marsh, Gabor Mihala, Karen Davies, Claire Rickard
BACKGROUND: Research has identified high failure rates of peripheral intravenous catheter (PIVC) and varied flushing practices. METHODS: This is a single-centre, pilot, non-masked, factorial randomised controlled trial. Participants were adults, with a PIVC of expected use ≥24 hours (n = 160), admitted to general medical or surgical wards of a tertiary referral hospital in Queensland (Australia). Patients were randomly allocated to one of four flush groups using manually prepared syringes and 0...
2016: Trials
Mamoudou Sétamou, Olufemi J Alabi, Madhurababu Kunta, John L Jifon, John V da Graça
The Asian citrus psyllid preferentially feeds and exclusively reproduces on young, newly emerged flush shoots of citrus. Asian citrus psyllid nymphs feed and complete their life stages on these flush shoots. Recent studies conducted under greenhouse conditions have shown that the transmission rates of 'Candidatus Liberibacter asiaticus' (CLas), the putative causal agent of huanglongbing disease of citrus, are enhanced when flush shoots are present. However, it is unclear if CLas acquisition by migrant adult Asian citrus psyllids is similarly enhanced...
October 2016: Journal of Economic Entomology
Eduardo José Ferreira Dos Santos, Maria Madalena Jesus Cunha Nunes, Daniela Filipa Batista Cardoso, João Luís Alves Apóstolo, Paulo Joaquim Pina Queirós, Manuel Alves Rodrigues
OBJECTIVE: Determining which is the most effective solution (heparin flush compared to 0.9% saline flush) for reducing the risk of occlusions in central venous catheters (CVC) in adults. METHOD: The systematic review followed the principles proposed by the Cochrane Handbook; critical analysis, extraction and synthesis of data were performed by two independent researchers; statistical analysis was performed using the RevMan program 5.2.8. RESULTS: Eight randomized controlled trials and one cohort study were included and the results of the meta-analysis showed no difference (RR=0...
December 2015: Revista da Escola de Enfermagem da U S P
K R Lindsay, M J Furlong
The banana-spotting bug, Amblypelta lutescens lutescens Distant (Hemiptera: Coreidae), is native to Australia and a major polyphagous pest of many tropical and subtropical horticultural crops in the east and north of the country. Different plant structures (flowers, vegetative flush, and different sized fruit) of avocado, lime, and papaya crops and green bean pods (a known suitable host) were evaluated for their suitability as hosts for A. l. lutescens Neonate to imago survivorship, the time taken to complete neonate to imago development, preovipositional period, and fecundity were assessed for each crop...
August 2016: Journal of Economic Entomology
Mohamed Shariful Islam, Zarih Alcheikh Hassan, Florence Chalmin, Sandor Vido, Mohamed Berrada, David Verhelst, Patrick Donnadieu, Olivier Moranne, Vincent L M Esnault
BACKGROUND: Hemodialysis requires effective anticoagulation to avoid blood circuit clotting. In patients at high risk for bleeding, several alternative methods have been developed. STUDY DESIGN: Multicenter, prospective, randomized, crossover study evaluating the noninferiority of vitamin E-coated compared with heparin-coated dialyzers in a 4-hour heparin-free hemodialysis strategy. SETTINGS & PARTICIPANTS: 32 adult long-term hemodialysis patients from 2 French hemodialysis units with well-functioning fistulas or double-lumen catheters...
June 23, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
T Onabanjo, K Patchigolla, S T Wagland, B Fidalgo, A Kolios, E McAdam, A Parker, L Williams, S Tyrrel, E Cartmell
Non-sewered sanitary systems (NSS) are emerging as one of the solutions to poor sanitation because of the limitations of the conventional flush toilet. These new sanitary systems are expected to safely treat faecal waste and operate without external connections to a sewer, water supply or energy source. The Nano Membrane Toilet (NMT) is a unique domestic-scale sanitary solution currently being developed to treat human waste on-site. This toilet will employ a small-scale gasifier to convert human faeces into products of high energy value...
June 15, 2016: Energy Conversion and Management
L Lorefice, G Fenu, F Cabras, J Frau, G C Coghe, L Loi, M G Marrosu, E Cocco
BACKGROUND: Notoriously the treatment of multiple sclerosis (MS) is based on the use of several different drugs, characterized by a diverse mechanism of action, efficacy and safety. Recently, progress has been made towards developing new oral immunotherapies, and dimethyl fumarate is the third oral agent approved for the treatment of relapsing-remitting forms. CASE: A 24-year-old patient, affected by relapsing remitting multiple sclerosis, started treatment in December 2014 with dimethyl fumarate...
May 2016: Multiple Sclerosis and related Disorders
Tanveer Dhanoya, Lynnette Leidy Sievert, Shanthi Muttukrishna, Khurshida Begum, Taniya Sharmeen, Adetayo Kasim, Osul Chowdhury, Gillian R Bentley
INTRODUCTION: Evidence suggests that hot flushes are associated with fluctuating levels of oestradiol (E2) during menopause, as well as changes in the levels of follicle-stimulating hormone (FSH) and inhibin B. The relationship between hot flushes and anti-Müllerian hormone (AMH) is unknown. AIM: To examine specific hormone levels and ethnic differences in relation to hot flushes. METHODS: Data were drawn from 108 women aged 40-59 years. There were three groups of participants: European women in London, UK; Bangladeshi women in Sylhet, Bangladesh; and Bangladeshi women who had migrated to London as adults...
July 2016: Maturitas
Ryo Nakazato, Reza Arsanjani, Aryeh Shalev, Jonathon A Leipsic, Heidi Gransar, Fay Y Lin, Millie Gomez, Daniel S Berman, James K Min
RATIONALE AND OBJECTIVES: The impact of iso-osmolar versus low-osmolar iodinated contrast on diagnostic accuracy for coronary computed tomography angiography (CCTA), against the reference standard of invasive coronary angiography (ICA), has not been determined. We sought to compare in an international multicenter randomized controlled trial the impact of iso-osmolar iodixanol versus low-osmolar iopamidol on diagnostic accuracy, image quality, patient symptoms, and heart rate variability...
June 2016: Academic Radiology
Natsumi Takahashi, Philip M C Davy, Lauren H Gardner, Juanita Mathews, Yuki Yamazaki, Richard C Allsopp
Pluripotent stem cells of the early embryo, and germ line cells, are essential to ensure uncompromised development to adulthood as well as species propagation, respectively. Recently, the transcription factor hypoxia inducible factor 1 alpha (Hif1α) has been shown to have important roles in embryonic stem cells; in particular, regulation of conversion to glycolytic metabolism and, as we have shown, maintenance of functional levels of telomerase. In the present study, we sought to assess whether Hif1α was also expressed in the primitive cells of the murine embryo...
2016: PloS One
Yong-Biao Liu, Kenneth F Haynes
Control of bed bugs is problematic, balancing among efficacy, safety, and cost. In this study, ultralow oxygen (ULO) and vacuum treatments were tested on bed bugs to develop a safer, effective, and environmentally friendly solution to kill bed bugs on infested items. ULO treatments were established by flushing sealed enclosures with nitrogen. All life stages of bed bugs were found to be susceptible to ULO and vacuum treatments, and efficacy of the treatments increased with reduced oxygen levels, increased treatment time, and temperature...
April 22, 2016: Journal of Economic Entomology
Josephine A Afema, Denis K Byarugaba, Devendra H Shah, Esther Atukwase, Maria Nambi, William M Sischo
In sub‒Saharan Africa, non‒typhoidal Salmonellae (NTS) cause invasive disease particularly in children and HIV infected adults, but the disease epidemiology is poorly understood. Between 2012 and 2013, we investigated NTS sources and transmission in Kampala. We detected Salmonella in 60% of the influent and 60% of the effluent samples from a wastewater treatment plant and 53.3% of the influent and 10% of the effluent samples from waste stabilization ponds that serve the human population; 40.9% of flush‒water samples from ruminant slaughterhouses, 6...
2016: PloS One
Naila Makhani, Teri Schreiner
BACKGROUND: First-line injectable therapies for multiple sclerosis in children may be ineffective or not well-tolerated. There is therefore an urgent need to explore oral medications for pediatric multiple sclerosis. We review our dual-center experience with oral dimethyl fumarate. METHODS: This study was a retrospective review of children 18 years of age or less with multiple sclerosis treated with dimethyl fumarate at Yale University and the University of Colorado...
April 2016: Pediatric Neurology
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