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https://www.readbyqxmd.com/read/29649197/metronidazole-stewardship-initiative-at-christchurch-hospitals-achievable-with-immediate-benefits
#1
Sharon J Gardiner, Sarah Cl Metcalf, Paul Kl Chin, Matthew P Doogue, Simon C Dalton, Stephen T Chambers
AIMS: To evaluate an antimicrobial stewardship (AMS) initiative to change hospital prescribing practice for metronidazole. METHODS: In October 2015, the Canterbury District Health Board (CDHB) AMS committee changed advice for metronidazole to promote two times daily dosing for most indications, prioritisation of the oral route and avoidance of double anaerobic cover. Adoption of the initiative was facilitated via change in prescribing guidelines, education and ongoing pharmacy support...
April 13, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29625901/megalopyge-opercularis-caterpillar-stings-reported-to-texas-poison-centers
#2
Mathias B Forrester
INTRODUCTION: The Megalopyge opercularis caterpillar is covered with spines that break off and release venom on contact, resulting in severe pain, erythema, rash, and other adverse effects. In Texas, these caterpillars are abundant and of potential health threat. This study describes M opercularis caterpillar stings reported to Texas poison centers. METHODS: Cases were M opercularis caterpillar stings reported to Texas poison centers during 2000-2016. The distribution of stings was determined related to exposure circumstances and management...
April 3, 2018: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/29621287/weather-and-landscape-factors-affect-white-tailed-deer-neonate-survival-at-ecologically-important-life-stages-in-the-northern-great-plains
#3
Eric S Michel, Jonathan A Jenks, Kyle D Kaskie, Robert W Klaver, William F Jensen
Offspring survival is generally more variable than adult survival and may limit population growth. Although white-tailed deer neonate survival has been intensively investigated, recent work has emphasized how specific cover types influence neonate survival at local scales (single study area). These localized investigations have often led to inconsistences within the literature. Developing specific hypotheses describing the relationships among environmental, habitat, and landscape factors influencing white-tailed deer neonate survival at regional scales may allow for detection of generalized patterns...
2018: PloS One
https://www.readbyqxmd.com/read/29620793/antidepressants-versus-placebo-for-panic-disorder-in-adults
#4
REVIEW
Irene Bighelli, Mariasole Castellazzi, Andrea Cipriani, Francesca Girlanda, Giuseppe Guaiana, Markus Koesters, Giulia Turrini, Toshi A Furukawa, Corrado Barbui
BACKGROUND: Panic disorder is characterised by repeated, unexpected panic attacks, which represent a discrete period of fear or anxiety that has a rapid onset, reaches a peak within 10 minutes, and in which at least four of 13 characteristic symptoms are experienced, including racing heart, chest pain, sweating, shaking, dizziness, flushing, stomach churning, faintness and breathlessness. It is common in the general population with a lifetime prevalence of 1% to 4%. The treatment of panic disorder includes psychological and pharmacological interventions...
April 5, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29600123/association-between-baseline-blood-pressures-heart-rates-and-vasovagal-syncope-in-children-and-adolescents
#5
Himanshu Adlakha, Ruchi Gupta, Romana Hassan, Jeffrey H Kern
BACKGROUND: Vasovagal syncope is the most common cause of syncope in children and adults, accounting for 50-66% of unexplained syncope. There are no studies establishing the relationship between syncope, baseline heart rate, and blood pressure. OBJECTIVE: To identify a possible association between baseline blood pressure and heart rate with syncope. DESIGN/METHODS: We conducted a questionnaire-based chart review study. A questionnaire was distributed to the guardian of children between eight and 18 years of age who attended the Pediatric Ambulatory Care Clinic at Flushing Hospital Medical Center...
January 28, 2018: Curēus
https://www.readbyqxmd.com/read/29547049/lanreotide-therapy-in-carcinoid-syndrome-prospective-analysis-of-patient-reported-symptoms-in-patients-responsive-to-prior-octreotide-therapy-and-patients-na%C3%A3-ve-to-somatostatin-analogue-therapy-in-the-elect-phase-3-study
#6
George A Fisher, Edward M Wolin, Nilani Liyanage, Susan Pitman Lowenthal, Beloo Mirakhur, Rodney F Pommier, Montaser Shaheen, Aaron I Vinik
OBJECTIVE: This ELECT prospective analysis examined lanreotide depot/autogel for carcinoid syndrome (CS) symptom control in patients with neuroendocrine tumors (NETs) who were responsive to prior octreotide (prior octreotide group) compared with patients who were naïve to prior somatostatin analogue treatment (de novo group). METHODS: Adults with histopathologically confirmed NET and stable CS (diarrhea and/or flushing) were randomized to subcutaneous (SC) lanreotide 120 mg or placebo every 4 weeks for 16 weeks...
March 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29530653/implementation-of-a-clinical-bundle-to-reduce-out-of-hospital-peri-intubation-hypoxia
#7
Jeffrey L Jarvis, John Gonzales, Danny Johns, Lauren Sager
STUDY OBJECTIVE: Peri-intubation hypoxia is an important adverse event of out-of-hospital rapid sequence intubation. The aim of this project is to determine whether a clinical bundle encompassing positioning, apneic oxygenation, delayed sequence intubation, and goal-directed preoxygenation is associated with decreased peri-intubation hypoxia compared with standard out-of-hospital rapid sequence intubation. METHODS: We conducted a retrospective, before-after study using data from a suburban emergency medical services (EMS) system in central Texas...
March 9, 2018: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29497320/bone-marrow-mesenchymal-stem-cells-as-nuclear-donors-improve-viability-and-health-of-cloned-horses
#8
R Olivera, L N Moro, R Jordan, N Pallarols, A Guglielminetti, C Luzzani, S G Miriuka, G Vichera
Introduction: Cell plasticity is crucial in cloning to allow an efficient nuclear reprogramming and healthy offspring. Hence, cells with high plasticity, such as multipotent mesenchymal stem cells (MSCs), may be a promising alternative for horse cloning. In this study, we evaluated the use of bone marrow-MSCs (BM-MSCs) as nuclear donors in horse cloning, and we compared the in vitro and in vivo embryo development with respect to fibroblasts. Materials and methods: Zona-free nuclear transfer was performed using BM-MSCs (MSC group, n=3432) or adult fibroblasts (AF group, n=4527)...
2018: Stem Cells and Cloning: Advances and Applications
https://www.readbyqxmd.com/read/29489704/factors-contributing-to-phlebitis-among-adult-patients-admitted-in-the-medical-surgical-units-of-a-central-hospital-in-harare-zimbabwe
#9
Munashe Livion Nyika, Doreen Mukona, Mathilda Zvinavashe
This descriptive survey identified factors contributing to phlebitis among 46 adult inpatients using a systematic random sample. The visual infusion phlebitis score was used for assessment. All participants had phlebitis, with stage 4 being most frequent. Factors identified were gender (males-91.7%); immunosuppression (human immunodeficiency virus-63.0%; diabetes-100%; immunosuppressive drugs-100%; absolute leucocyte count <1000 μL-100%); number of catheters inserted (>1-90.9%); site of catheterization (dorsum of wrist-100%); catheter dwell time (2-4 days-100%); catheter gauge (18-gauge-75%); catheter securement (unsecured/contaminated dressing-90%); regularity of catheter flushing (catheter never flushed-72...
March 2018: Journal of Infusion Nursing: the Official Publication of the Infusion Nurses Society
https://www.readbyqxmd.com/read/29471401/influence-of-tree-size-and-application-rate-on-expression-of-thiamethoxam-in-citrus-and-its-efficacy-against-diaphorina-citri-hemiptera-liviidae
#10
K W Langdon, R Schumann, L L Stelinski, M E Rogers
Neonicotinoids are a key group of insecticides used to manage Diaphorina citri Kuwayama (Hemiptera: Liviidae), in Florida citrus. Diaphorina citri is the vector of Candidatus Liberibacter asiaticus, the presumed causal agent of huanglongbing, a worldwide disease of citrus. A two-season field study was conducted to evaluate the effect of tree size and application rate on the expression of thiamethoxam in young citrus following application to the soil. D. citri adult and nymph abundance was also correlated with thiamethoxam titer in leaves...
February 20, 2018: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29462222/cross-sectional-survey-of-the-burden-of-illness-of-rosacea-by-erythema-severity
#11
Julie Harper, James Q Del Rosso, Ilia L Ferrusi
Rosacea is a chronic skin condition characterized by persistent central facial erythema. To explore the burden of illness of rosacea in US adults, a cross-sectional web-based survey was conducted. Participants answered questions on sociodemographics, clinical characteristics, bothersome symptoms, coping and avoidance behaviors, self-perceptions, and health care resource utilization, and completed 2 quality of life instruments, the 21-item rosacea-specific quality of life questionnaire (RosaQoL) and the 36-item Short Form Health Survey (SF-36)...
February 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29444845/antibacterial-activity-of-male-and-female-sperm-storage-organs-in-ants
#12
Francisco Dávila, Anne Botteaux, David Bauman, Sarah Chérasse, Serge Aron
Bacteria can damage sperm and thus reduce the reproductive success of both males and females; selection should therefore favour the evolution of antimicrobial protection. Eusocial hymenopterans might be particularly affected by such bacterial infections because of their mating ecology. In both sexes, mating is restricted to a short window early in the adult stage; there are no further chances to mate later in life. Males die shortly after mating, but queens use the acquired sperm to fertilise their eggs for years, sometimes decades...
February 14, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29419626/effect-of-a-patency-bundle-on-central-venous-catheter-complications-among-hospitalized-adult-patients-a-best-practice-implementation-project
#13
Vivian Huang
OBJECTIVES: The aim of this project was to improve continuity of care by decreasing central catheter occlusions in adults in two acute care units with high use of central venous catheters. Specific objectives were to introduce a patency bundle and train nurses on thrombolytic administration for timely resolution of catheter occlusions. INTRODUCTION: Central venous catheters are a vital component of medical care of acutely ill hospitalized patients. Occluded catheters delay treatment and can increase infection risk...
February 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29373671/modeling-the-phenology-of-asian-citrus-psyllid-hemiptera-liviidae-in-urban-southern-california-effects-of-environment-habitat-and-natural-enemies
#14
Ivan Milosavljevic, Ruth Amrich, Vincent Strode, Mark S Hoddle, Kevin Heinz
Modeling can be used to characterize the effects of environmental drivers and biotic factors on the phenology of arthropod pests. From a biological control perspective, population dynamics models may provide insights as to when the most vulnerable pest life stages are available for natural enemies to attack. Analyses presented here used temperature and habitat dependent, instar-specific, discrete models to investigate the population dynamics of Asian citrus psyllid, Diaphorina citri Kuwayama (Hemiptera: Liviidae)...
January 24, 2018: Environmental Entomology
https://www.readbyqxmd.com/read/29350062/telotristat-ethyl-a-novel-agent-for-the-therapy-of-carcinoid-syndrome-diarrhea
#15
Joseph S Dillon, Chandrikha Chandrasekharan
Carcinoid syndrome (CS), characterized by diarrhea and flushing, is present in 20% of patients with neuroendocrine tumors at diagnosis and becomes more frequent with progression. The diarrhea of CS is caused mainly by tumoral secretion of serotonin. It may not be fully controlled by somatostatin analogs, the currently indicated drugs for symptomatic relief. Telotristat ethyl is a novel inhibitor of tryptophan hydroxylase, the rate-limiting enzyme in serotonin biosynthesis. Administration of the drug decreases diarrhea in patients with CS...
January 19, 2018: Future Oncology
https://www.readbyqxmd.com/read/29304052/citrus-flush-shoot-ontogeny-modulates-biotic-potential-of-diaphorina-citri
#16
Juan Camilo Cifuentes-Arenas, António de Goes, Marcelo Pedreira de Miranda, George Andrew Charles Beattie, Silvio Aparecido Lopes
The biology and behaviour of the psyllid Diaphorina citri Kuwayama (Hemiptera: Sternorrhyncha: Liviidae), the major insect vector of bacteria associated with huanglongbing, have been extensively studied with respect to host preferences, thermal requirements, and responses to visual and chemical volatile stimuli. However, development of the psyllid in relation to the ontogeny of immature citrus flush growth has not been clearly defined or illustrated. Such information is important for determining the timing and frequency of measures used to minimize populations of the psyllid in orchards and spread of HLB...
2018: PloS One
https://www.readbyqxmd.com/read/29236706/contrasting-amino-acid-profiles-among-permissive-and-non-permissive-hosts-of-candidatus-liberibacter-asiaticus-putative-causal-agent-of-huanglongbing
#17
Mamoudou Sétamou, Olufemi J Alabi, Catherine R Simpson, John L Jifon
Huanglongbing is a devastating disease of citrus. In this study, a comprehensive profile of phloem sap amino acids (AA) in four permissive host plants of Candidatus Liberibacter asiaticus (CLas) and three non-permissive Rutaceae plants was conducted to gain a better understanding of host factors that may promote or suppress the bacterium. The AA profiles of Diaphorina citri nymphs and adults were similarly analyzed. A total of 38 unique AAs were detected in phloem sap of the various plants and D. citri samples, with phloem sap of young shoots containing more AAs and at higher concentrations than their mature counterparts...
2017: PloS One
https://www.readbyqxmd.com/read/29236231/dimethyl-fumarate-a-review-in-moderate-to-severe-plaque-psoriasis
#18
Hannah A Blair
Fumaric acid esters (FAEs) have been used in the treatment of psoriasis in some European countries for over 20 years, and are recommended in the European guidelines for the management of moderate to severe plaque psoriasis. Dimethyl fumarate (Skilarence® ; hereafter referred to as DMF) is an orally administered FAE indicated for the treatment of moderate to severe plaque psoriasis in adults in need of systemic medicinal therapy; unlike other available FAEs, it is not formulated in combination with monoethyl fumarate salts...
January 2018: Drugs
https://www.readbyqxmd.com/read/29218681/management-strategies-to-facilitate-optimal-outcomes-for-patients-treated-with-delayed-release-dimethyl-fumarate
#19
Lori Mayer, Mary Kay Fink, Carrie Sammarco, Lisa Laing
Delayed-release dimethyl fumarate is an oral disease-modifying therapy that has demonstrated significant efficacy in adults with relapsing-remitting multiple sclerosis. Incidences of flushing and gastrointestinal adverse events are common in the first month after delayed-release dimethyl fumarate initiation. Our objective was to propose mitigation strategies for adverse events related to initiation of delayed-release dimethyl fumarate in the treatment of patients with multiple sclerosis. Studies of individually developed mitigation strategies and chart reviews were evaluated...
December 7, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29201957/saline-flush-versus-chest-x-ray-in-confirmation-of-central-venous-catheter-placement-a-diagnostic-accuracy-study
#20
Mehrdad Esmailian, Reza Azizkhani, Nazila Najafi
Introduction: Central venous catheterization (CVC) is a commonly performed procedure in critically ill patients of emergency department. This study was designed to compare the diagnostic accuracy of saline flush with CXR in confirmation of above-the-diaphragm CVC placement. Methods: This prospective cross sectional study was conducted on adult patients in need of CVC placement in emergency department. Placement Confirmation was performed with saline flush method and CXR, then chest computed tomography (CT) was performed as the gold standard...
2017: Emergency (Tehran, Iran)
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