Natali Froese, Malgorzata Szaroszyk, Paolo Galuppo, Joseph R Visker, Christopher Werlein, Mortimer Korf-Klingebiel, Dominik Berliner, Marc R Reboll, Rana Hamouche, Simona Gegel, Yong Wang, Winfried Hofmann, Ming Tang, Robert Geffers, Adam R Wende, Mark P Kühnel, Danny D Jonigk, Georg Hansmann, Kai C Wollert, E Dale Abel, Stavros G Drakos, Johann Bauersachs, Christian Riehle
BACKGROUND: Alveolar hypoxia is protective in the context of cardiovascular and ischemic heart disease; however, the underlying mechanisms are incompletely understood. The present study sought to test the hypothesis that hypoxia is cardioprotective in left ventricular pressure overload (LVPO)-induced heart failure. We furthermore aimed to test that overlapping mechanisms promote cardiac recovery in heart failure patients following left ventricular assist device-mediated mechanical unloading and circulatory support...
February 6, 2024: Journal of the American Heart Association