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Hodgkin lympoma

Eitan Shaulian
Since its discovery more than two decades ago the involvement of the Activating protein 1 (AP-1) in proliferation, inflammation, differentiation, apoptosis, cellular migration and wound healing has been intensively studied. A model based on the early studies suggested antagonistic roles for the Jun proteins in proliferation and transformation. c-Jun was suggested to enhance transformation whereas JunB suggested to inhibit it in an antagonistic manner. Surprisingly, despite accumulation of data obtained from animal models regarding the role of Jun proteins in cancer and identification of oncogenic pathways regulating them, their involvement in human cancer was not demonstrated until recently...
June 2010: Cellular Signalling
María Florencia Villafañe, Norberto Trione, Marcelo Corti, Nora Mendez, Elisa Gancedo, Norberto Zamora, Marta Levin
Non-Hodgkin's lymphomas (NHL) are the second most frequent malignancies in AIDS patients. The majority of NHL associated with AIDS involves extranodal sites, especially the digestive tract and the central nervous system. Primary liver lymphoma (PLL) is an uncommon neoplasm among these patients. Ultrasonography and computed tomography scans may be helpful in the diagnosis of focal hepatic lymphoma. Image-guided fine-needle biopsy with histopathology of the liver lesions is the gold standard for the diagnosis of hepatic lymphoma...
July 2006: Revista do Instituto de Medicina Tropical de São Paulo
R Albrecht, B Krebs, E Reusche, M Nagel, R Lencer, H A Kretzschmar
Intravascular lymphomatosis (IVL), a rare type of non-Hodgkin's lymphoma, is an uncommon cause of progressive dementia, usually followed by death within a few months of onset of clinical disease. Often this aggressive tumor is only diagnosed at autopsy, because of misleading clinical features mimicking a broad spectrum of syndromes and the absence of circulating lympoma cells in the blood, bone marrow or cerebrospinal fluid in many cases. Here we present IVL in a 78-year-old woman with findings leading to the clinical diagnosis of vascular dementia with sudden beginning and positive 14-3-3 protein in the CSF, commonly reported in Creutzfeldt-Jakob disease (CJD)...
August 2005: European Archives of Psychiatry and Clinical Neuroscience
C Sigg, H J Plüss, W H Hitzig
From 1964-1978 primary non-Hodgkin's lymphoma was diagnosed and treated in 15 children (13 boys and 2 girls). In the 10 patients treated up to 1974, median survival was only 4 months (the longest being 16 months). Since 1974 all such patients have been put on high-dose combined chemotherapy as early as possible. Of 5 children thus treated, 3 have survived for 60, 26 and 11 months respectively and are still alive disease-free. The other two died after 4 1/2 and 5 1/2 months respectively: both had very widespread disease at diagnosis and chemotherapy was delayed by postoperative complications...
July 8, 1980: Schweizerische Medizinische Wochenschrift
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