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Type B dissection

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https://www.readbyqxmd.com/read/28102592/six-uneventful-pregnancy-outcomes-in-an-extended-vascular-ehlers-danlos-syndrome-family
#1
Annette F Baas, Wilko Spiering, Frans L Moll, Lieve Page-Christiaens, Ingrid C M Beenakkers, Dennis Dooijes, Evert-Jan P A Vonken, Jasper J van der Smagt, Nine V Knoers, Steven V Koenen, Joost A van Herwaarden, Gertjan Tj Sieswerda
Vascular Ehlers-Danlos Syndrome (vEDS) is caused by heterozygous mutations in COL3A1 and is characterized by fragile vasculature and hollow organs, with a high risk of catastrophic events at a young age. During pregnancy and delivery, maternal mortality rates up until 25% have been reported. However, recent pedigree analysis reported a substantial lower pregnancy-related mortality rate of 4.9%. Here, we describe an extended vEDS family with multiple uneventful pregnancy outcomes. In the proband, a 37-year-old woman, DNA-analysis because of an asymptomatic iliac artery dissection revealed a pathogenic mutation in COL3A1 (c...
February 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28078746/a-gly65val-substitution-in-an-actin-ghact_li1-disrupts-cell-polarity-and-f-actin-organization-resulting-in-dwarf-lintless-cotton-plants
#2
Gregory N Thyssen, David D Fang, Rickie B Turley, Christopher B Florane, Ping Li, Christopher P Mattison, Marina Naoumkina
Actin polymerizes to form part of the cytoskeleton and organize polar growth in all eukaryotic cells. Species with numerous actin genes are especially useful for the dissection of actin molecular function due to redundancy and neofunctionalization. Here, we investigated the role of a cotton (Gossypium hirsutum) actin gene in the organization of actin filaments in lobed cotyledon pavement cells and the highly-elongated single-celled trichomes that comprise cotton lint fibers. Using mapping-by-sequencing, virus-induced gene silencing, and molecular modeling, we identified the causative mutation of the dominant dwarf Ligon-lintless Li1 short fiber mutant as a single Gly65Val amino acid substitution in a polymerization domain of an actin gene, GhACT_LI1 (Gh_D04G0865)...
January 12, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28070203/a-pilot-observational-study-on-magnesium-and-calcium-imbalance-in-elderly-patients-with-acute-aortic-dissection
#3
E Vianello, E Dozio, A Barassi, G Sammarco, L Tacchini, M M Marrocco-Trischitta, S Trimarchi, M M Corsi Romanelli
BACKGROUND: Magnesium (Mg) and calcium (Ca) are the principal essential elements involved in endothelial cell homeostasis. Extracellular changes in the levels of either alter endothelial contraction and dilatation. Consequently Mg and Ca imbalance is associated with a high risk of endothelial dysfunction, the main process observed during acute aortic dissection (AAD); in this clinical condition, which mainly affects elderly men, smooth muscle cell alterations lead to intimal tears, creating a false new lumen in the media of the aorta...
2017: Immunity & Ageing: I & A
https://www.readbyqxmd.com/read/28065240/endovascular-repair-for-acute-type-b-aortic-dissection
#4
Wei Ye, Chang-Wei Liu, Xiao-Jun Song, Yong-Jun Li, Bao Liu, Yue-Hong Zheng, Rong Zeng
Objective To report experience and result of endovascular repair for acute type B aortic dissection (ATBD). Methods Totally 125 ATBD patients receiving endovascular repair with stent-graft were enrolled in this study. Demographic data,operation details,perioperative findings,and follow-up results were retrospectively analyzed. Results All the 125 patients were successfully implanted with 135 stent-grafts. Thirteen cases were covered left subclavian artery,16 cases underwent left subclavian artery revascularization,and 10 cases underwent visceral artery revascularization...
December 20, 2016: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28057590/modular-endoscopic-medial-maxillectomies-quantitative-analysis-of-surgical-exposure-in-a-preclinical-setting
#5
Alberto Schreiber, Marco Ferrari, Vittorio Rampinelli, Francesco Doglietto, Francesco Belotti, Davide Lancini, Marco Ravanelli, Luigi Fabrizio Rodella, Marco Maria Fontanella, Piero Nicolai
BACKGROUND: Endoscopic medial maxillectomies (EMM) have been named with different nomenclatures. Aim of the present study was to objectively measure the surgical exposure in a preclinical anatomical setting to validate a classification for modular EMMs. MATERIALS AND METHODS: Six cadaver heads underwent computed tomography and images were uploaded on a dedicated software. A neuronavigation system was used to measure areas and volumes of surgical corridors during dissection...
January 2, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28045241/evidence-for-and-risks-of-endovascular-treatment-of-asymptomatic-acute-type-b-aortic-dissection
#6
Rachel E Clough, Christoph A Nienaber
Acute aortic dissection is a challenging disease to manage. Type B aortic dissection has traditionally been divided temporally into acute and chronic cases but more recently this classification has been modified to include a sub-acute phase. Computed tomography is the imaging technique used most frequently in diagnosis and management. Active management of blood pressure is essential and should include beta-blockade unless contra-indicated. In-hospital outcomes are generally acceptable in patients with medically managed acute uncomplicated type B aortic dissection, with up to 90% of patients surviving to hospital discharge but by 5-years up to 50% of patients are dead with a significant proportion dying from aortic rupture...
January 3, 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28028452/burkholderia-pseudomallei-type-iii-secreted-protein-bipc-role-in-actin-modulation-and-translocation-activities-required-for-the-bacterial-intracellular-lifecycle
#7
Wen Tyng Kang, Kumutha Malar Vellasamy, Lakshminarayanan Rajamani, Roger W Beuerman, Jamuna Vadivelu
Melioidosis, an infection caused by the facultative intracellular pathogen Burkholderia pseudomallei, has been classified as an emerging disease with the number of patients steadily increasing at an alarming rate. B. pseudomalleipossess various virulence determinants that allow them to invade the host and evade the host immune response, such as the type III secretion systems (TTSS). The products of this specialized secretion system are particularly important for the B. pseudomallei infection. Lacking in one or more components of the TTSS demonstrated different degrees of defects in the intracellular lifecycle of B...
2016: PeerJ
https://www.readbyqxmd.com/read/28025311/operative-results-of-the-anterolateral-thoracotomy-with-partial-sternotomy-approach-for-chronic-type-b-aortic-dissection-involving-the-aortic-arch
#8
Gaku Uchino, Keiji Yunoki, Naoya Sakoda, Shigeru Hattori, Takuya Kawabata, Munehiro Saiki, Yasufumi Fujita, Kunikazu Hisamochi, Hideo Yoshida, Osamu Oba
OBJECTIVES: There are various treatment strategies for chronic-type B aortic dissection involving the aortic arch. Our aim was to review our surgical experience in the anterolateral thoracotomy with the partial sternotomy approach for chronic-type B aortic dissection involving the aortic arch. METHODS: From January 2000 to October 2015, 39 patients underwent the single-stage open surgery for chronic-type B aortic dissection involving the aortic arch using the anterolateral thoracotomy with partial sternotomy approach...
December 26, 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28018832/limited-distal-arch-open-stenting-for-type-b-aortic-dissection-with-an-enlarged-ulcer-like-projection-complicated-by-abdominal-aortic-occlusion
#9
Mitsumasa Hata, Kenji Akiyama, Yukihiko Orime
A 79-year-old man underwent bifurcated graft replacement for abdominal aortic aneurysm, but the graft was totally occluded owing to an acute type B aortic dissection. We could not have access to the root for performing endovascular stenting for dissecting aneurysm. Furthermore, it was difficult to remove the aneurysm via a left thoracotomy because it was impossible to perfuse the lower body with blood from the femoral artery and also a left axillary arterial cannulation was unusable. Herein, we report a patient who was successfully treated with open surgical aortic stenting for an enlarged ulcer-like projection complicated by a type B aortic dissection...
December 2016: Thoracic and Cardiovascular Surgeon Reports
https://www.readbyqxmd.com/read/28018508/fatal-hemorrhage-from-kidney-after-endovascular-repair-for-chronic-type-b-dissection-complicated-with-disseminated-intravascular-coagulation
#10
Takashi Yamauchi, Suguru Kubota, Kosei Hasegawa, Shinya Shirai
We report lethal hemorrhage from the kidney after thoracic endovascular repair for chronic type B dissection complicated by disseminated intravascular coagulation (DIC). A 70-year-old woman underwent thoracic endovascular repair to treat chronic DIC. Two weeks after surgery, refractory shock suddenly occurred and computed tomography showed a massive hematoma around the left kidney. Emergent renal artery angiography showed multiple bleeding points in the renal cortex. Immediate embolization of the renal artery was performed and her hemodynamic condition recovered...
2016: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/28012696/postoperative-myocardial-infarction-after-acute-type-a-dissection-another-day-another-database
#11
EDITORIAL
Leora B Balsam, Abe DeAnda
No abstract text is available yet for this article.
November 15, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27998737/anatomical-study-and-clinical-application-of-facial-artery-perforator-flaps-in-intraoral-reconstruction-focusing-on-venous-system
#12
Wei-Na Zhou, Lin-Zhong Wan, Ping Zhang, Hua Yuan, Hong-Bing Jiang, Yi-Fei Du
PURPOSE: Facial artery perforator flaps (FAPFs) are preferred for the repair of intraoral and peri-nasal defects because it is a convenient procedure with minimal donor-site morbidity. The purpose of this study was to investigate the anatomic features of FAPFs and present their clinical application in intraoral reconstruction. MATERIALS AND METHODS: Five cadaver specimens (10 sides) of the head and neck region and 90 clinical cases (90 sides) of neck dissection were analyzed to explore the facial venous drainage system of FAPFs...
November 26, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27993378/aortic-remodeling-after-endovascular-repair-of-complicated-acute-type-b-aortic%C3%A2-dissection
#13
Bradley G Leshnower, Yazan M Duwayri, Edward P Chen, Chun Li, Carl A Zehner, Jose N Binongo, Ravi K Veeraswamy
BACKGROUND: Thoracic endovascular aortic repair (TEVAR) is the optimal therapy for complicated acute type B aortic dissection (aTBAD). This study examined clinical outcomes and aortic remodeling parameters after TEVAR for patients with complicated aTBAD. METHODS: From January 2012 to December 2015, 51 patients underwent TEVAR for complicated aTBAD. Preoperative and postoperative imaging studies were analyzed for sizes of the true lumen (TL) and false lumen (FL) and for the FL thrombosis status at five locations in the thoracic and abdominal aorta...
December 16, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27989058/transcatheter-aortic-valve-replacement-in-type-b-aortic-dissection
#14
Iosif Gulkarov, Akanibo Da-Wariboko, Ashwad Afzal, Arash Salemi, Berhane Worku
Transcatheter aortic valve replacement (TAVR) has become an acceptable alternative to surgical aortic valve replacement in high-risk and inoperable patients. Several technical and anatomical considerations can increase the complexity and risk of the procedure, and therefore are considered as contraindications to TAVR. Patients with significant aortic disease such as aortic dissection are not usually considered for TAVR due to risk of aortic rupture or retrograde extension of the dissection. Herein is presented a report of the first successful TAVR in a patient with extensive type B dissection...
March 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/27981196/social-defeat-stress-induces-depression-like-behavior-and-alters-spine-morphology-in-the-hippocampus-of-adolescent-male-c57bl-6-mice
#15
Sergio D Iñiguez, Antonio Aubry, Lace M Riggs, Jason B Alipio, Roseanna M Zanca, Francisco J Flores-Ramirez, Mirella A Hernandez, Steven J Nieto, David Musheyev, Peter A Serrano
Social stress, including bullying during adolescence, is a risk factor for common psychopathologies such as depression. To investigate the neural mechanisms associated with juvenile social stress-induced mood-related endophenotypes, we examined the behavioral, morphological, and biochemical effects of the social defeat stress model of depression on hippocampal dendritic spines within the CA1 stratum radiatum. Adolescent (postnatal day 35) male C57BL/6 mice were subjected to defeat episodes for 10 consecutive days...
December 2016: Neurobiology of Stress
https://www.readbyqxmd.com/read/27978814/switchfinder-a-novel-method-and-query-facility-for-discovering-dynamic-gene-expression-patterns
#16
Svetlana Bulashevska, Colin Priest, Daniel Speicher, Jörg Zimmermann, Frank Westermann, Armin B Cremers
BACKGROUND: Biological systems and processes are highly dynamic. To gain insights into their functioning time-resolved measurements are necessary. Time-resolved gene expression data captures temporal behaviour of the genes genome-wide under various biological conditions: in response to stimuli, during cell cycle, differentiation or developmental programs. Dissecting dynamic gene expression patterns from this data may shed light on the functioning of the gene regulatory system. The present approach facilitates this discovery...
December 15, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27977791/peptide-processing-is-critical-for-t-cell-memory-inflation-and-may-be-optimized-to-improve-immune-protection-by-cmv-based-vaccine-vectors
#17
Iryna Dekhtiarenko, Robert B Ratts, Renata Blatnik, Lian N Lee, Sonja Fischer, Lisa Borkner, Jennifer D Oduro, Thomas F Marandu, Stephanie Hoppe, Zsolt Ruzsics, Julia K Sonnemann, Mandana Mansouri, Christine Meyer, Niels A W Lemmermann, Rafaela Holtappels, Ramon Arens, Paul Klenerman, Klaus Früh, Matthias J Reddehase, Angelika B Riemer, Luka Cicin-Sain
Cytomegalovirus (CMV) elicits long-term T-cell immunity of unparalleled strength, which has allowed the development of highly protective CMV-based vaccine vectors. Counterintuitively, experimental vaccines encoding a single MHC-I restricted epitope offered better immune protection than those expressing entire proteins, including the same epitope. To clarify this conundrum, we generated recombinant murine CMVs (MCMVs) encoding well-characterized MHC-I epitopes at different positions within viral genes and observed strong immune responses and protection against viruses and tumor growth when the epitopes were expressed at the protein C-terminus...
December 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27974466/steps-for-shigella-gatekeeper-mxic-function-in-hierarchical-type-iii-secretion-regulation
#18
A Dorothea Roehrich, Enrica Bordignon, Selma Mode, Da-Kang Shen, Xia Liu, Maria Pain, Isabel Murillo, Isabel Martinez-Argudo, Richard B Sessions, Ariel J Blocker
Type III secretion systems are complex nanomachines used for injection of proteins from Gram-negative bacteria into eukaryotic cells. While they are assembled when the environmental conditions are appropriate, they only start secreting upon contact with a host cell. Secretion is hierarchical: first, the pore-forming translocators are released, next, effector proteins are injected. Hierarchy between these protein classes is mediated by a conserved gate-keeper protein, MxiC in Shigella. As its molecular mechanism of action is still poorly understood, we used its structure to guide site-directed mutagenesis and dissect its function...
December 14, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27956321/prevalence-incidence-and-risk-factors-for-shoulder-and-neck-dysfunction-after-neck-dissection-a-systematic-review
#19
REVIEW
E M Gane, Z A Michaleff, M A Cottrell, S M McPhail, A L Hatton, B J Panizza, S P O'Leary
INTRODUCTION: Shoulder pain and dysfunction may occur following neck dissection among people being treated for head and neck cancer. This systematic review aims to examine the prevalence and incidence of shoulder and neck dysfunction after neck dissection and identify risk factors for these post-operative complications. METHODS: Electronic databases (Pubmed, CINAHL, EMBASE, Cochrane) were searched for articles including adults undergoing neck dissection for head and neck cancer...
November 17, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27941931/in-vivo-functional-dissection-of-a-context-dependent-role-for-hif1%C3%AE-in-pancreatic-tumorigenesis
#20
T Cheng, Z Jian, K Li, S Raulefs, I Regel, S Shen, X Zou, J Ruland, G O Ceyhan, H Friess, C W Michalski, J Kleeff, B Kong
Hypoxia-inducible factor 1α (Hif1α) is a key regulator of cellular adaptation and survival under hypoxic conditions. In pancreatic ductal adenocarcinoma (PDAC), it has been recently shown that genetic ablation of Hif1α accelerates tumour development by promoting tumour-supportive inflammation in mice, questioning its role as the key downstream target of many oncogenic signals of PDAC. Likely, Hif1α has a context-dependent role in pancreatic tumorigenesis. To further analyse this, murine PDAC cell lines with reduced Hif1α expression were generated using shRNA transfection...
December 12, 2016: Oncogenesis
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