Sheba John, Luciana T Young, Ronald V Lacro, Arvind Hoskoppal, Zhining Ou, Angela Presson, Joyce T Johnson, Lauren Andrade, L LuAnn Minich, Shaji Menon
We performed a secondary analysis of the Pediatric Heart Network Marfan Trial public-use database to evaluate associations between extracardiac features and cardiac and aortic phenotypes in study participants. Aortic aneurysm phenotype was defined as aortic root Z-score ≥ 4.5, aortic root growth rate ≥ 75th percentile, aortic dissection, and aortic surgery. Severe cardiac phenotype was defined as aortic dissection, aortic Z-score ≥4.5, aortic valve surgery, at least moderate mitral regurgitation, mitral valve surgery, left ventricular dysfunction, or death...
March 4, 2024: Research Square