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https://www.readbyqxmd.com/read/27900191/deaths-in-triathletes-immersion-pulmonary-oedema-as-a-possible-cause
#1
Richard E Moon, Stefanie D Martina, Dionne F Peacher, William E Kraus
BACKGROUND/AIM: To address the question as to whether immersion pulmonary oedema (IPO) may be a common cause of death in triathlons, markers of swimming-induced pulmonary oedema (SIPO) susceptibility were sought in triathletes' postmortem examinations. METHODS: Deaths while training for or during triathlon events in the USA and Canada from October 2008 to November 2015 were identified, and postmortem reports requested. We assessed obvious causes of death; the prevalence of left ventricular hypertrophy (LVH); comparison with healthy triathletes...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27873227/the-relationship-between-aortic-root-size-and-hypertension-an-unsolved-conundrum
#2
Giuseppe Mulè, Emilio Nardi, Massimiliano Morreale, Antonella Castiglia, Giulio Geraci, Dario Altieri, Valentina Cacciatore, Margherita Schillaci, Francesco Vaccaro, Santina Cottone
Thoracic aortic aneurysms rupture and dissection are among the most devastating vascular diseases, being characterized by elevated mortality, despite improvements in diagnostic imaging and surgical techniques.An increased aortic root diameter (ARD) represents the main risk factor for thoracic aortic dissection and rupture and for aortic valve regurgitation.Even though arterial hypertension is commonly regarded as a predisposing condition for the development of thoracic aorta aneurysms, the role of blood pressure (BP) as determinant of aortic root enlargement is still controversial...
November 22, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27846929/-ccafu-french-national-guidelines-2016-2018-on-testicular-germ-cell-tumors
#3
X Durand, A Fléchon, T Murez, L Rocher, P Camparo, N Morel-Journel, P-H Savoie, L Ferretti, P Sèbe, A Méjean
INTRODUCTION: The purpose of the oncologic comitee of the french association of urology was to establish guidelines proposed by the external genital organ group, for the diagnosis, treatment and follow-up of the germ cell tumours of the testis. MATERIAL AND METHODS: The multidisciplinary working group studied 2013 guidelines, exhaustively reviewed the literature, and evaluated references and their level of proof in order to attribute grades of recommandation. RESULTS: The initial workup of testicular cancer is based on clinical, laboratory (AFP, total hCG, LDH) and imaging assessment (scrotal ultrasound and chest, abdomen and pelvis computed tomography)...
November 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27802285/mmp-2-isoforms-in-aortic-tissue-and-serum-of-patients-with-ascending-aortic-aneurysms-and-aortic-root-aneurysms
#4
Anke Tscheuschler, Philipp Meffert, Friedhelm Beyersdorf, Claudia Heilmann, Nadja Kocher, Xenia Uffelmann, Philipp Discher, Matthias Siepe, Fabian A Kari
OBJECTIVE: The need for biological markers of aortic wall stress and risk of rupture or dissection of ascending aortic aneurysms is obvious. To date, wall stress cannot be related to a certain biological marker. We analyzed aortic tissue and serum for the presence of different MMP-2 isoforms to find a connection between serum and tissue MMP-2 and to evaluate the potential of different MMP-2 isoforms as markers of high wall stress. METHODS: Serum and aortic tissue from n = 24 patients and serum from n = 19 healthy controls was analyzed by ELISA and gelatin zymography...
2016: PloS One
https://www.readbyqxmd.com/read/27779166/association-of-plasma-pentraxin-3-levels-on-admission-with-in-hospital-mortality-in-patients-with-acute-type-a-aortic-dissection
#5
Qin Zhou, Xiang-Ping Chai, Zhen-Fei Fang, Xin-Qun Hu, Liang Tang
BACKGROUND: Acute aortic dissection is a life-threatening cardiovascular emergency. Pentraxin-3 (PTX3) is proposed as a prognostic marker and found to be related to worse clinical outcomes in various cardiovascular diseases. This study sought to investigate the association of circulating PTX3 levels with in-hospital mortality in patients with acute Type A aortic dissection (TAAD). METHODS: A total of 98 patients with TAAD between January 2012 and December 2015 were enrolled in this study...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27644881/dynamic-autophagic-activity-affected-the-development-of-thoracic-aortic-dissection-by-regulating-functional-properties-of-smooth-muscle-cells
#6
Yang Wang, Zhi-Min Zhao, Guan-Xin Zhang, Fan Yang, Yan Yan, Su-Xuan Liu, Song-Hua Li, Guo-Kun Wang, Zhi-Yun Xu
The aortic medial degeneration is the key histopathologic feature of Thoracic aortic dissection (TAD). The aim of this study was to identify the change of autophagic activity in the aortic wall during TAD development, and to explore the roles of autophagy on regulating functional properties of smooth muscle cells (SMCs). Firstly, compared with control group (n = 11), the increased expression of autophagic markers Beclin1 and LC3 was detected in the aortic wall from TAD group (n = 23) by immunochemistry and western blot...
October 14, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27593537/biomarkers-investigation-for-in-hospital-death-in-patients-with-stanford-type-a-acute-aortic-dissection
#7
Ruoxi Zhang, Shuyuan Chen, Hui Zhang, Wei Wang, Jianpang Xing, Yu Wang, Bo Yu, Jingbo Hou
This retrospective study aimed to investigate the predictive value of biomarkers for in-hospital mortality of patients with Stanford type A acute aortic dissection (AAD).AAD is a life-threatening disease with an incidence of about 2.6-3.6 cases per 100,000/year.A total of 67 consecutive Stanford type A AAD patients admitted to hospital were divided into a deceased group and survival group. The baseline information of the patients between two groups was systematically compared, followed by examination of the electrocardiograms (ECG)...
September 28, 2016: International Heart Journal
https://www.readbyqxmd.com/read/27578577/-protective-effects-of-high-dose-ulinastatin-on-vital-organs-in-patients-receiving-total-arch-replacement-for-type-a-aortic-dissection
#8
Xian-Yue Wang, Wen-Peng Dong, Guang Tong, Sheng-Hui Bi, Ben Zhang, Hua Lu, Xiao-Wu Wang, Wei-da Zhang
OBJECTIVE: To investigate the protective effects of high-dose ulinastatin on the vital organs in patients undergoing total arch replacement for type A aortic dissection. METHODS: Between September 2014 and March 2016, 66 patients with type A aortic dissection underwent total arch replacement at our center. Thirty-six of the patients received ulinastatin treatment at 300 000 U/8 h from admission to 3 days postoperatively and at 300 000 U/2 h during cardiopulmonary bypass surgery (UTI group), and the other 30 patients did not receive perioperative ulinastatin treatment (control group)...
August 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27514842/a-case-of-ovarian-adenosquamous-carcinoma-arising-from-endometrioid-adenocarcinoma-a-case-report-and-systematic-review
#9
Tadahiro Shoji, Eriko Takatori, Kazuyuki Murakami, Yoshitaka Kaido, Satoshi Takeuchi, Akihiko Kikuchi, Toru Sugiyama
BACKGROUND: The aims of this report were to describe a case of ovarian adenosquamous carcinoma and to systematically review the pertinent literature. METHODS: We describe a case in which a 57-year-old woman had stage IC ovarian cancer histologically diagnosed as adenosquamous carcinoma. We also systematically reviewed the literature using the PubMed database. CASE PRESENTATION: Preoperative computed tomography and magnetic resonance imaging showed a tumor measuring 14 cm in diameter and containing solid areas...
2016: Journal of Ovarian Research
https://www.readbyqxmd.com/read/27497325/genotyping-of-the-c-1423c-t-p-p475s-polymorphism-in-the-adamts13-gene-by-aplp-and-hrm-assays-northeastern-asian-origin-of-the-mutant
#10
Mayumi Nakagawa, Aya Matsusue, Kazuo Umetsu, Morio Iino, Takaki Ishikawa, Isao Yuasa
ADAMTS13 is a von Willebrand factor-cleaving protease. The mutant types of p.P475S (c.1423C>T) polymorphism in ADAMTS13 have a reduced activity in comparison with the wild type. In the present study, we investigated the frequency of the C-to-T substitution in 2584 genomic DNA samples from 25 Asian, European, and African populations using APLP (amplified product length polymorphism) and/or HRM (high-resolution melting) assays. Allele T (ADAMTS13(∗)T) was detected only in Asian populations and its frequency was observed to decrease gradually from north to south in 24 East Asian populations...
July 2016: Legal Medicine
https://www.readbyqxmd.com/read/27432091/a-fever-in-acute-aortic-dissection-is-caused-by-endogenous-mediators-that-influence-the-extrinsic-coagulation-pathway-and-do-not-elevate-procalcitonin
#11
Yoshie Inoue Arita, Koichi Akutsu, Takeshi Yamamoto, Hidekazu Kawanaka, Mitsunobu Kitamura, Hiroshige Murata, Hideki Miyachi, Yusuke Hosokawa, Keiji Tanaka, Wataru Shimizu
Objective A fever is observed in approximately one-third of cases of acute aortic dissection (AAD); however, the causes remain unclear. We investigated the mechanism of a fever in AAD by measuring the serum concentrations of inflammatory markers, mediators of coagulation and fibrinolysis, and procalcitonin, a marker of bacterial infection. Methods We retrospectively studied 43 patients with medically treated AAD without apparent infection. Patients were divided into those with (Group A; n=19) and without (Group B; n=24) a maximum body temperature >38°C...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27432090/admission-values-of-d-dimer-and-c-reactive-protein-crp-predict-the-long-term-outcomes-in-acute-aortic-dissection
#12
Kentaro Mori, Hidetaka Tamune, Hiroyuki Tanaka, Mitsuhiro Nakamura
Objective Admission D-dimer and C-reactive protein (CRP) values have been reported to predict the short-term outcomes in acute aortic dissection (AAD). However, the association between D-dimer values and the long-term outcomes has not been investigated. Methods The primary endpoints included events determined to be all-cause death, recurrence of aortic dissection, aortic rupture, and surgical intervention for the aortic aneurysm following the first hospital discharge. We performed a receiver operating characteristic analysis and determined the optimal cut-off levels of admission D-dimer, admission CRP and peak CRP values in terms of the sensitivity and specificity for predicting the presence of events...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27423717/need-for-limb-revascularization-in-patients-with-acute-aortic-dissection-is-associated-with-mesenteric-ischemia
#13
Kristofer M Charlton-Ouw, Harleen K Sandhu, Samuel S Leake, Katherine Jeffress, Charles C Miller, Christopher A Durham, Tom C Nguyen, Anthony L Estrera, Hazim J Safi, Ali Azizzadeh
INTRODUCTION: /Objectives: Acute aortic dissection (AAD) can cause limb ischemia due to branch vessel occlusion. A minority of patients have persistent ischemia after central aortic repair and require peripheral arterial revascularization. We investigated whether the need for limb revascularization is associated with adverse outcomes. METHODS: We reviewed our cases of AAD from 2000 to 2014 and identified patients with malperfusion syndromes (coronary, cerebral, spinal, visceral, renal, or peripheral ischemia)...
July 13, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27318339/-the-significance-of-a-4-183-da-peptide-of-dermcidin-protein-in-the-early-diagnosis-and-differential-diagnosis-of-acute-coronary-syndrome
#14
Feng Kai, Liu Lifeng, Song Haijing, Liu Xianhua, Xia Hu
OBJECTIVE: To investigate the predictive value of 4,183 Da peptide of dermcidin protein in the early diagnosis and differential diagnosis of ischemic heart disease. METHODS: A prospective controlled study was conducted. Serum samples were drawn from 161 patients with acute coronary'syndrome [ACS, including 46 patients with unstable angina (UA), 23 with acute non-ST elevation myocardial infarction, and 92 with acute ST segment elevation myocardial infarction], 111 subjects for routine physical examination, including 45 patients with hypertension history, 42 with coronary heart disease, 22 with diabetes, and 54 patients with non-ACS (including pulmonary embolism, aortic dissection, aneurysm, arrhythmia, myocarditis, coronary myocardial bridge, pleurisy, pneumothorax pneumomediastinum, rib fracture, reflux esophagitis, peptic ulcer, and pancreatitis) to serve as controls...
December 2015: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/27274304/marfan-syndrome-current-perspectives
#15
REVIEW
Guglielmina Pepe, Betti Giusti, Elena Sticchi, Rosanna Abbate, Gian Franco Gensini, Stefano Nistri
Marfan syndrome (MFS) is a pleiotropic connective tissue disease inherited as an autosomal dominant trait, due to mutations in the FBN1 gene encoding fibrillin 1. It is an important protein of the extracellular matrix that contributes to the final structure of a microfibril. Few cases displaying an autosomal recessive transmission are reported in the world. The FBN1 gene, which is made of 66 exons, is located on chromosome 15q21.1. This review, after an introduction on the clinical manifestations that leads to the diagnosis of MFS, focuses on cardiovascular manifestations, pharmacological and surgical therapies of thoracic aortic aneurysm and/or dissection (TAAD), mechanisms underlying the progression of aneurysm or of acute dissection, and biomarkers associated with progression of TAADs...
2016: Application of Clinical Genetics
https://www.readbyqxmd.com/read/27221957/editor-s-choice-biomarkers-of-acute-cardiovascular-and-pulmonary-diseases
#16
REVIEW
Toru Suzuki, Alexander Lyon, Rajeev Saggar, Liam M Heaney, Kenichi Aizawa, Antonio Cittadini, Ciro Mauro, Rodolfo Citro, Giuseppe Limongelli, Francesco Ferrara, Olga Vriz, Andrew Morley-Smith, Paolo Calabrò, Eduardo Bossone
Acute cardiothoracic and respiratory diseases frequently remain a challenge to diagnose and differentiate in the emergency setting. The main diseases that manifest with chest pain include ischaemic heart disease, myocarditis, acute pericarditis, aortic dissection/rupture and pulmonary embolism (PE). Diseases that primarily present with dyspnoea include heart failure (HF), acute respiratory distress syndrome (ARDS), pneumonia, asthma exacerbations and chronic obstructive pulmonary disease. Pre-test probabilities of clinical findings play a vital part in diagnostic decisions, and the use of a Bayesian approach to these greatly improves the ability to stratify patients more accurately...
September 2016: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/27177921/rapid-identification-of-type-a-aortic-dissection-as-a-cause-of-acute-ischemic-stroke
#17
Tomoyuki Ohara, Masatoshi Koga, Naoki Tokuda, Eijirou Tanaka, Hiroyuki Yokoyama, Kenji Minatoya, Kazuyuki Nagatsuka, Kazunori Toyoda, Kazuo Minematsu
BACKGROUND AND PURPOSE: Patients with acute aortic dissection (AAD) sometimes present predominantly with neurological symptoms from cerebral ischemia. Such stroke patients must not receive thrombolysis therapy, which can be fatal. However, patients remain at risk if there is a failure to notice concurrent AAD. We aimed to clarify the characteristics of AAD patients with stroke to identify markers for early AAD detection before thrombolysis. METHODS: Using the single-center database of Stanford type A-AAD patients between 2007 and 2013, we selected those presenting with acute focal neurological deficits, presumably due to cerebral ischemia...
August 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27082771/prognostic-effect-of-cardiac-troponin-elevation-in-acute-aortic-dissection-a-meta-analysis
#18
Mislav Vrsalovic
BACKGROUND: Acute aortic dissection (AAD) is a highly lethal medical emergency that requires immediate assessment and therapy. To date, no one biomarker plays a significant role in risk stratification of patients with AAD and whether cardiac troponin could be a prognostic marker of in-hospital mortality is still unknown. METHODS AND RESULTS: To assess the prognostic role of cardiac troponin elevation during AAD, we performed an updated systematic review and meta-analysis...
July 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27081079/which-patients-with-para-aortic-lymph-node-ln16-metastasis-will-truly-benefit-from-curative-pancreaticoduodenectomy-for-pancreatic-head-cancer
#19
Chen Liu, Yu Lu, Guopei Luo, He Cheng, Meng Guo, Zuqiang Liu, Jin Xu, Jiang Long, Liang Liu, Deliang Fu, Quanxing Ni, Min Li, Xianjun Yu
In patients with cancer of the pancreatic head, metastasis to para-aortic lymph nodes (LN16) is considered distant metastasis and a poor prognostic marker. However, the incidence of LN16 involvement in pancreatic head cancer is high, and it is unclear whether all such patients have poor surgical outcomes. We investigated the significance of LN16 involvement in resectable pancreatic head cancer by retrospectively analyzing 579 ductal adenocarcinoma patients treated with para-aortic lymph node dissection at two high-volume Chinese centers...
May 17, 2016: Oncotarget
https://www.readbyqxmd.com/read/27009066/%C3%AE-v%C3%AE-3-integrin-targeted-microspect-ct-imaging-of-inflamed-atherosclerotic-plaques-in-mice
#20
David Vancraeynest, Véronique Roelants, Caroline Bouzin, François-Xavier Hanin, Stephan Walrand, Vanesa Bol, Anne Bol, Anne-Catherine Pouleur, Agnès Pasquet, Bernhard Gerber, Philippe Lesnik, Thierry Huby, François Jamar, Jean-Louis Vanoverschelde
BACKGROUND: αVβ3-integrin is expressed by activated endothelial cells and macrophages in atherosclerotic plaques and may represent a valuable marker of high-risk plaques. We evaluated (99m)Tc-maraciclatide, an integrin-specific tracer, for imaging vascular inflammation in atherosclerotic lesions in mice. METHODS: Apolipoprotein E-negative (ApoE(-/-)) mice on a Western diet (n = 10) and normally fed adult C57BL/6 control mice (n = 4) were injected with (99m)Tc-maraciclatide (51...
December 2016: EJNMMI Research
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