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aortic dissection marker

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https://www.readbyqxmd.com/read/28625769/mechanisms-of-aortic-dissection-smooth-muscle-cell-phenotype-switch
#1
Zhao An, Yang Liu, Zhi-Gang Song, Hao Tang, Yang Yuan, Zhi-Yun Xu
OBJECTIVE: To investigate the expression of Nanog homeobox (NANOG) in thoracic aortic dissection (TAD) and the role of NANOG in regulating human aortic vascular smooth muscle cells (VSMCs) phenotype switch. METHODS: Aortic specimens were collected from 20 patients undergoing TAD and 10 controls. VSMCs were isolated by adherent cultivation approach. The expression of NANOG, osteopontin (OPN), and VSMCs phenotype markers were determined by quantitative real-time polymerase chain reaction, Western blot, immunohistochemistry, and immunofluorescence...
May 25, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28619541/can-renal-resistive-index-predict-acute-kidney-injury-after-acute-type-a-aortic-dissection-repair
#2
Hai-Bo Wu, Huai Qin, Wei-Guo Ma, Hong-Lei Zhao, Jun Zheng, Jian-Rong Li, Li-Zhong Sun
BACKGROUND: This study sought to determine whether assessment of the renal resistive index (RRI) can predict the short-term reversibility of acute kidney injury (AKI) after repair of acute type A aortic dissection (TAAD). METHODS: This prospective study included 62 patients undergoing repair of acute TAAD. Doppler-based RRIs were obtained preoperatively, immediately after the surgical procedure, and 6, 24, and 48 hours postoperatively. The occurrence of AKI was evaluated daily according to Acute Kidney Injury Network criteria...
June 13, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28596478/significance-of-the-thrombo-inflammatory-status-based-novel-prognostic-score-as-a-useful-predictor-for-in-hospital-mortality-of-patients-with-type-b-acute-aortic-dissection
#3
Dongze Li, Lei Ye, Jing Yu, Lixia Deng, Lianjing Liang, Yan Ma, Lei Yi, Zhi Zeng, Yu Cao, Zhi Wan
BACKGROUND: Inflammation and thrombosis are associated with development and progression of acute aortic dissection (AAD). The aim of this study was to assess the prognostic significance of Simplified Thrombo-Inflammatory Prognostic Score (sTIPS), in patients with early phase type B AAD. METHODS: We retrospectively reviewed 491 patients with type B AAD between November 2012 and September 2015. sTIPS was calculated from the white blood cell count (WBC) and mean platelet volume to platelet count (MPV/PC) ratio, at the time of admission...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28485317/early-kinetics-of-procalcitonin-in-predicting-surgical-outcomes-in-type-a-aortic-dissection-patients
#4
Hua Liu, Zhe Luo, Lan Liu, Xiao-Mei Yang, Ya-Min Zhuang, Ying Zhang, Guo-Wei Tu, Guo-Guang Ma, Guang-Wei Hao, Jian-Feng Luo, Ji-Li Zheng, Chun-Sheng Wang
BACKGROUND: In cardiac surgery, elevation of procalcitonin (PCT) could be observed postoperatively in the absence of any evidence of infection and also seems to be a prognostic marker. PCT levels measured in patients undergoing Type A aortic dissection (TAAD) were used to determine prognostic values for complications and surgical outcomes. METHODS: Measurements of PCT, C-reactive protein (CRP), and leukocyte count were observed in TAAD surgery patients (n = 251; average age: 49...
May 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28360264/changing-the-paradigm-in-type-b-acute-aortic-dissection-combining-clinical-and-imaging-markers-of-risk
#5
EDITORIAL
Troy M LaBounty, Kim A Eagle
No abstract text is available yet for this article.
April 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28344201/stenotic-bicuspid-and-tricuspid-aortic-valves%C3%A3-micro-computed-tomography-and-biological-indices-of-calcification
#6
Piotr Mazur, Ewa Wypasek, Bogusław Gawęda, Dorota Sobczyk, Przemysław Kapusta, Joanna Natorska, Krzysztof Piotr Malinowski, Jacek Tarasiuk, Maciej Bochenek, Sebastian Wroński, Katarzyna Chmielewska, Bogusław Kapelak, Anetta Undas
BACKGROUND: Valve calcification is well estimated by ex-vivo micro-computed tomography (micro-CT). The objective of this study was to investigate the associations between micro-CT findings and biological indices of calcification in aortic stenosis (AS), as well as differences between bicuspid aortic valve (BAV) and tricuspid aortic valve (TAV).Methods and Results:Aortic valves and plasma were obtained from patients undergoing valve surgery. Valves were dissected and underwent micro-CT, genetic analyses, and calcium content assessment...
March 24, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28302143/altered-aortic-3d-hemodynamics-and-geometry-in-pediatric-marfan-syndrome-patients
#7
Roel L F van der Palen, Alex J Barker, Emilie Bollache, Julio Garcia, Michael J Rose, Pim van Ooij, Luciana T Young, Arno A W Roest, Michael Markl, Joshua D Robinson, Cynthia K Rigsby
BACKGROUND: Blood flow dynamics make it possible to better understand the development of aortopathy and cardiovascular events in patients with Marfan syndrome (MFS). Aortic 3D blood flow characteristics were investigated in relation to aortic geometry in children and adolescents with MFS. METHODS: Twenty-five MFS patients (age 15.6 ± 4.0 years; 11 females) and 21 healthy controls (age 16.0 ± 2.6 years; 12 females) underwent magnetic resonance angiography and 4D flow CMR for assessment of thoracic aortic size and 3D blood flow velocities...
March 17, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28290181/acute-type-a-aortic-dissection-beyond-the-diameter
#8
Calogera Pisano, Carmela Rita Balistreri, Oreste Fabio Triolo, Vincenzo Argano, Giovanni Ruvolo
Aortic dissection is a life-threatening condition in which early diagnosis, treatment and close follow up are critical for survival. Between 60% and 70% of patients with acute aortic dissection are affected at the ascending aorta, classified as Stanford type A (TAD). Preventive surgery of the aorta in asymptomatic patients on the basis of aortic size alone remains controversial among patient populations without known risk factors for aortic dissection. In fact, many dissection patients do not appear to have markedly dilated aortas at the time of presentation...
November 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28262748/diagnostic-implication-of-fibrin-degradation-products-and-d-dimer-in-aortic-dissection
#9
Jian Dong, Xianli Duan, Rui Feng, Zhiqing Zhao, Xiang Feng, Qingsheng Lu, Qing Jing, Jian Zhou, Junmin Bao, Zaiping Jing
Fibrin degradation products (FDP) and D-dimer have been considered to be involved in many vascular diseases. In this study we aimed to explore the diagnostic implication of FDP and D-dimer in aortic dissection patients. 202 aortic dissection patients were collected as the case group, 150 patients with other cardiovascular diseases, including myocardial infarction (MI, n = 45), pulmonary infarction (n = 51) and abdominal aortic aneurysm (n = 54) were collected as non-dissection group, and 27 healthy people were in the blank control group...
March 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28167124/p38-mapk-signaling-pathway-mediates-angiotensin-ii-induced-mir143-145-gene-cluster-downregulation-during-aortic-dissection-formation
#10
Bowen Li, Zhiwei Wang, Zhipeng Hu, Min Zhang, Zongli Ren, Zhen Zhou, Jizhen Huang, Xiaoping Hu
BACKGROUND: We endeavored to prove that angiotensin II (Ang II) regulates both the expression of micro-RNA143/145 (miR143/145) and differentiation of vascular smooth muscle cells (VSMCs) during the formation of aortic dissection (AD). We also studied the contribution of p38 mitogen-activated protein kinase (MAPK) signaling pathway toward this process. METHODS: Ascending aortic tissues were harvested from the patients with AD and organ donors. Tissues were immunostained with labeled antibodies targeting p38 MAPK, phospho-p38 MAPK, alpha-smooth muscle actin (α-SMA), and osteopontin (OPN)...
February 4, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28161919/cysts-of-the-iris-pigment-epithelium-what-is-new-and-interesting-the-2016-jose-rizal-international-medal-lecture
#11
REVIEW
Jerry A Shields, Carol L Shields
PURPOSE: Cysts of the iris pigment epithelium (IPE) can involve the pupillary margin, midzone, or peripheral location or can be free-floating in the aqueous or vitreous or lodged in the anterior chamber angle. Avariant of IPE cyst, known as iris flocculi, can be a marker for systemic thoracic aneurysm. DESIGN: Review of IPE cysts and description of new observations of the lesions. METHODS: Review of IPE cysts. RESULTS: Lesions in 672 eyes were classified as of the pupillary margin (n = 49; 7%), midzone (n = 188; 28%), peripheral (n = 424; 63%), or dislodged/free-floating (n = 11; 2%)...
January 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28133109/-four-cases-of-colorectal-cancer-with-para-aortic-lymph-node-metastases-successfully-resected-resulting-in-long-term-survival
#12
Yudai Yamamoto, Makoto Aoki, Keisuke Nakao, Kenji Shitara, Tetsuji Hayashi, Hiroyuki Fukunari, Gen Watanabe, Yoichi Ajioka
We encountered 4 cases of colorectal cancer with para-aortic lymph node(LN)metastases.Para -aortic LN dissection was performed after the diagnosis of solitary LN metastases.Case 1: A 69-year-old woman was diagnosed with ascending colon cancer.She underwent right hemicolectomy with D3 LN dissection.After 1 year and 3 months, tumor marker levels(CEA) were elevated, and para-aortic LN metastases were detected on CT.She was administered FOLFOX.After 1 year, para-aortic LN dissection was performed.She is doing well without any recurrence for 8 years and 9 months...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27975141/glucose-and-angiotensin-ii-derived-endothelial-extracellular-vesicles-regulate-endothelial-dysfunction-via-erk1-2-activation
#13
Kumiko Taguchi, Mari Hida, Haruka Narimatsu, Takayuki Matsumoto, Tsuneo Kobayashi
In various diseases, including diabetes, extracellular vesicles (EVs) have been detected in circulation and tissues. EVs are small membrane vesicles released from various cell types under varying conditions. Recently, endothelial cell-derived EVs (EEVs) were identified as a marker of endothelial dysfunction in diabetes, but the ensuing mechanisms remain poorly understood. In this study, we dissected the ensuing pathways with respect to nitric oxide (NO) production under the condition of type 2 diabetes. Human umbilical vein endothelial cells (HUVECs) were stimulated with glucose alone and with glucose in combination with angiotensin II (Ang II) for 48 h...
December 14, 2016: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/27900191/deaths-in-triathletes-immersion-pulmonary-oedema-as-a-possible-cause
#14
Richard E Moon, Stefanie D Martina, Dionne F Peacher, William E Kraus
BACKGROUND/AIM: To address the question as to whether immersion pulmonary oedema (IPO) may be a common cause of death in triathlons, markers of swimming-induced pulmonary oedema (SIPO) susceptibility were sought in triathletes' postmortem examinations. METHODS: Deaths while training for or during triathlon events in the USA and Canada from October 2008 to November 2015 were identified, and postmortem reports requested. We assessed obvious causes of death; the prevalence of left ventricular hypertrophy (LVH); comparison with healthy triathletes...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27873227/the-relationship-between-aortic-root-size-and-hypertension-an-unsolved-conundrum
#15
Giuseppe Mulè, Emilio Nardi, Massimiliano Morreale, Antonella Castiglia, Giulio Geraci, Dario Altieri, Valentina Cacciatore, Margherita Schillaci, Francesco Vaccaro, Santina Cottone
Thoracic aortic aneurysms rupture and dissection are among the most devastating vascular diseases, being characterized by elevated mortality, despite improvements in diagnostic imaging and surgical techniques.An increased aortic root diameter (ARD) represents the main risk factor for thoracic aortic dissection and rupture and for aortic valve regurgitation.Even though arterial hypertension is commonly regarded as a predisposing condition for the development of thoracic aorta aneurysms, the role of blood pressure (BP) as determinant of aortic root enlargement is still controversial...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27846929/-ccafu-french-national-guidelines-2016-2018-on-testicular-germ-cell-tumors
#16
REVIEW
X Durand, A Fléchon, T Murez, L Rocher, P Camparo, N Morel-Journel, P-H Savoie, L Ferretti, P Sèbe, A Méjean
INTRODUCTION: The purpose of the oncologic comitee of the french association of urology was to establish guidelines proposed by the external genital organ group, for the diagnosis, treatment and follow-up of the germ cell tumours of the testis. MATERIAL AND METHODS: The multidisciplinary working group studied 2013 guidelines, exhaustively reviewed the literature, and evaluated references and their level of proof in order to attribute grades of recommandation. RESULTS: The initial workup of testicular cancer is based on clinical, laboratory (AFP, total hCG, LDH) and imaging assessment (scrotal ultrasound and chest, abdomen and pelvis computed tomography)...
November 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27802285/mmp-2-isoforms-in-aortic-tissue-and-serum-of-patients-with-ascending-aortic-aneurysms-and-aortic-root-aneurysms
#17
Anke Tscheuschler, Philipp Meffert, Friedhelm Beyersdorf, Claudia Heilmann, Nadja Kocher, Xenia Uffelmann, Philipp Discher, Matthias Siepe, Fabian A Kari
OBJECTIVE: The need for biological markers of aortic wall stress and risk of rupture or dissection of ascending aortic aneurysms is obvious. To date, wall stress cannot be related to a certain biological marker. We analyzed aortic tissue and serum for the presence of different MMP-2 isoforms to find a connection between serum and tissue MMP-2 and to evaluate the potential of different MMP-2 isoforms as markers of high wall stress. METHODS: Serum and aortic tissue from n = 24 patients and serum from n = 19 healthy controls was analyzed by ELISA and gelatin zymography...
2016: PloS One
https://www.readbyqxmd.com/read/27779166/association-of-plasma-pentraxin-3-levels-on-admission-with-in-hospital-mortality-in-patients-with-acute-type-a-aortic-dissection
#18
Qin Zhou, Xiang-Ping Chai, Zhen-Fei Fang, Xin-Qun Hu, Liang Tang
BACKGROUND: Acute aortic dissection is a life-threatening cardiovascular emergency. Pentraxin-3 (PTX3) is proposed as a prognostic marker and found to be related to worse clinical outcomes in various cardiovascular diseases. This study sought to investigate the association of circulating PTX3 levels with in-hospital mortality in patients with acute Type A aortic dissection (TAAD). METHODS: A total of 98 patients with TAAD between January 2012 and December 2015 were enrolled in this study...
November 5, 2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27644881/dynamic-autophagic-activity-affected-the-development-of-thoracic-aortic-dissection-by-regulating-functional-properties-of-smooth-muscle-cells
#19
Yang Wang, Zhi-Min Zhao, Guan-Xin Zhang, Fan Yang, Yan Yan, Su-Xuan Liu, Song-Hua Li, Guo-Kun Wang, Zhi-Yun Xu
The aortic medial degeneration is the key histopathologic feature of Thoracic aortic dissection (TAD). The aim of this study was to identify the change of autophagic activity in the aortic wall during TAD development, and to explore the roles of autophagy on regulating functional properties of smooth muscle cells (SMCs). Firstly, compared with control group (n = 11), the increased expression of autophagic markers Beclin1 and LC3 was detected in the aortic wall from TAD group (n = 23) by immunochemistry and western blot...
October 14, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27593537/biomarkers-investigation-for-in-hospital-death-in-patients-with-stanford-type-a-acute-aortic-dissection
#20
Ruoxi Zhang, Shuyuan Chen, Hui Zhang, Wei Wang, Jianpang Xing, Yu Wang, Bo Yu, Jingbo Hou
This retrospective study aimed to investigate the predictive value of biomarkers for in-hospital mortality of patients with Stanford type A acute aortic dissection (AAD).AAD is a life-threatening disease with an incidence of about 2.6-3.6 cases per 100,000/year.A total of 67 consecutive Stanford type A AAD patients admitted to hospital were divided into a deceased group and survival group. The baseline information of the patients between two groups was systematically compared, followed by examination of the electrocardiograms (ECG)...
September 28, 2016: International Heart Journal
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