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https://www.readbyqxmd.com/read/28877934/identification-of-senescent-cell-surface-targetable-protein-dpp4
#1
Kyoung Mi Kim, Ji Heon Noh, Monica Bodogai, Jennifer L Martindale, Xiaoling Yang, Fred E Indig, Sandip K Basu, Kei Ohnuma, Chikao Morimoto, Peter F Johnson, Arya Biragyn, Kotb Abdelmohsen, Myriam Gorospe
Senescent cell accumulation in aging tissues is linked to age-associated diseases and declining function, prompting efforts to eliminate them. Mass spectrometry analysis revealed that DPP4 (dipeptidyl peptidase 4) was selectively expressed on the surface of senescent, but not proliferating, human diploid fibroblasts. Importantly, the differential presence of DPP4 allowed flow cytometry-mediated isolation of senescent cells using anti-DPP4 antibodies. Moreover, antibody-dependent cell-mediated cytotoxicity (ADCC) assays revealed that the cell surface DPP4 preferentially sensitized senescent, but not dividing, fibroblasts to cytotoxicity by natural killer cells...
September 6, 2017: Genes & Development
https://www.readbyqxmd.com/read/28831355/elizabeth-croll-asps-patient-of-courage-2016
#2
Arun K Gosain
Mrs. Elizabeth Croll was selected as an American Society of Plastic Surgeons (ASPS) Patient of Courage in 2016. During a boating accident that occurred within 1 month after graduating from Harvard Business School, she was struck by an oncoming boat and suffered severe facial trauma, resulting in an open skull injury with loss of her right eye. She has since undergone multiple reconstructive surgical procedures beginning in 1997 and continuing up to the month before she was awarded the ASPS Patient of Courage...
July 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28814837/simulating-clinical-trial-visits-yields-patient-insights-into-study-design-and-recruitment
#3
S Sam Lim, Alan J Kivitz, Doug McKinnell, M Edward Pierson, Faye S O'Brien
PURPOSE: We elicited patient experiences from clinical trial simulations to aid in future trial development and to improve patient recruitment and retention. PATIENTS AND METHODS: Two simulations of draft Phase II and Phase III anifrolumab studies for systemic lupus erythematosus (SLE)/lupus nephritis (LN) were performed involving African-American patients from Grady Hospital, an indigent care hospital in Atlanta, GA, USA, and white patients from Altoona Arthritis and Osteoporosis Center in Altoona, PA, USA...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28811088/primary-prevention-aspirin-use-in-high-risk-patients-a-pharmacist-intervention-and-comparison-of-risk-stratification-tools
#4
Scott A Coon, Amie D Brooks, Stephen E Wolff
OBJECTIVES: The objectives of this project are 1) to describe aspirin use for primary prevention in an underserved, minority population; 2) to determine the impact of a pharmacist-led intervention on the prevalence of aspirin use for primary prevention; and 3) to compare aspirin indications based on Framingham Risk Score (FRS) and atherosclerotic cardiovascular disease (ASCVD) risk score. METHODS: Men and women age 45-79 and 55-79 years, respectively, without ASCVD were screened for aspirin use...
August 12, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28806966/an-exploratory-study-assessing-psychological-distress-of-indigents-in-burkina-faso-a-step-forward-in-understanding-mental-health-needs-in-west-africa
#5
Émilie Pigeon-Gagné, Ghayga Hassan, Maurice Yaogo, Valéry Ridde
BACKGROUND: Poverty is known as an important determinant of health, but empirical data are still missing on the relationships between poverty, other adverse living conditions, and psychological distress, particularly in low-income countries. This study aimed to assess mental health needs and psychological distress among the poorest in rural settings in Burkina Faso where food security and access to water, electricity, schooling, and healthcare are limited. METHODS: We randomly selected 2000 individuals previously identified as indigents by a community-targeting process...
August 14, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28765454/current-status-of-postdoctoral-and-graduate-programs-in-dentistry
#6
Leon Assael
Advanced dental education has evolved in the context of societal needs and economic trends to its current status. Graduate programs have positioned their role in the context of health systems and health science education trends in hospitals, interprofessional clinical care teams, and dental schools and oral health care systems. Graduate dental education has been a critical factor in developing teams in trauma care, craniofacial disorders, pediatric and adult medicine, and oncology. The misalignment of the mission of graduate dental programs and the demands of private practice has posed a challenge in the evolution of programs as educational programs have been directed towards tertiary and indigent care while the practice community focuses on largely healthy affluent patients for complex clinical interventions...
August 2017: Journal of Dental Education
https://www.readbyqxmd.com/read/28764785/pathways-for-scaling-up-public-health-interventions
#7
Devon Indig, Karen Lee, Anne Grunseit, Andrew Milat, Adrian Bauman
BACKGROUND: To achieve population-wide health improvement, public health interventions found effective in selected samples need to be 'scaled up' and implemented more widely. The pathways through which interventions are scaled up are not well characterised. The aim of this paper is to identify examples of public health interventions which have been scaled up and to develop a conceptual framework which quantifies and describes this process. METHODS: A multi-stage international literature search was undertaken to identify examples of public health interventions in high income countries that have been scaled up or implemented at scale...
August 1, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28688642/why-do-patients-receive-care-from-a-short-term-medical-mission-survey-study-from-rural-guatemala
#8
Micaela M Esquivel, Joy C Chen, Russell K Woo, Nora Siegler, Francisco A Maldonado-Sifuentes, Jehidy S Carlos-Ochoa, Andy R Cardona-Diaz, Tarsicio Uribe-Leitz, Dennis Siegler, Thomas G Weiser, George P Yang
BACKGROUND: Hospital de la Familia was established to serve the indigent population in the western highlands of Guatemala and has a full-time staff of Guatemalan primary care providers supplemented by short-term missions of surgical specialists. The reasons for patients seeking surgical care in this setting, as opposed to more consistent care from local institutions, are unclear. We sought to better understand motivations of patients seeking mission-based surgical care. METHODS: Patients presenting to the obstetric and gynecologic, plastic, ophthalmologic, general, and pediatric surgical clinics at the Hospital de la Familia from July 27 to August 6, 2015 were surveyed...
July 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28679598/mucuna-pruriens-in-parkinson-disease-a-double-blind-randomized-controlled-crossover-study
#9
RANDOMIZED CONTROLLED TRIAL
Roberto Cilia, Janeth Laguna, Erica Cassani, Emanuele Cereda, Nicolò G Pozzi, Ioannis U Isaias, Manuela Contin, Michela Barichella, Gianni Pezzoli
OBJECTIVE: To investigate whether Mucuna pruriens (MP), a levodopa-containing leguminous plant growing in all tropical areas worldwide, may be used as alternative source of levodopa for indigent individuals with Parkinson disease (PD) who cannot afford long-term therapy with marketed levodopa preparations. METHODS: We investigated efficacy and safety of single-dose intake of MP powder from roasted seeds obtained without any pharmacologic processing. Eighteen patients with advanced PD received the following treatments, whose sequence was randomized: (1) dispersible levodopa at 3...
August 1, 2017: Neurology
https://www.readbyqxmd.com/read/28617906/comprehensive-hearing-aid-intervention-at-a-free-subspecialty-clinic
#10
Aileen P Wertz, Gregory Mannarelli, Andrew G Shuman, Erin L McKean
Importance: Providing a model of a comprehensive free audiologic program may assist other health care professionals in developing their own similar program. Objective: To describe the structure, feasibility, and outcomes of a free subspecialty clinic providing hearing aids to develop a paradigm for other programs interested in implementing similar projects. Design, Setting, and Participants: A retrospective case series was conducted from September 1, 2013, through March 31, 2016...
June 15, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28617681/psychotropic-drugs-prescription-in-undocumented-migrants-and-indigent-natives-in-italy
#11
Cesare Cerri, Gianfrancesco Fiorini, Silvia Bini, Antonello E Rigamonti, Nicoletta Marazzi, Alessandro Sartorio, Silvano G Cella
To evaluate psychotropic drug use in undocumented migrants and natives in the same conditions of poverty. We studied drug dispensation by a nongovernmental organization during the year 2014. Drugs were identified according to the Anatomical Chemical Therapeutic classification and their quantity was measured in defined daily doses (DDD). We determined the percentage of patients taking at least one medicine with psychotropic activity in relation to the total number of patients receiving medicines of any class...
September 2017: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28610941/implementation-of-a-pharmacist-driven-immunization-program-designed-to-improve-overall-vaccination-rates-in-indigent-and-uninsured-patients
#12
Allison M Stilwell, Chris Pavero, Jennifer Buxton, Glenn Herrington
OBJECTIVE: To demonstrate the results of a pharmacist-driven immunization program designed to increase overall vaccination rates among the low-income, uninsured patients in a free clinic. SETTING: Cape Fear Clinic, a free clinic located in Wilmington, North Carolina. PRACTICE DESCRIPTION: Cape Fear Clinic provides medical, pharmacy, mental health, and dental services to adults in four eastern North Carolina counties who are uninsured and have incomes of no more than 200% of Federal Poverty Guidelines...
June 10, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28579849/vulnerable-habitats-alter-african-meliponine-bee-s-hymenoptera-apidae-assemblages-in-an-eastern-afromontane-biodiversity-hotspot
#13
Bridget O Bobadoye, Paul N Ndegwa, Lucy Irungu, Ayuka T Fombong
Habitat degradation has over time formed synergy with other factors to contribute to dwindling populations of both fauna and flora by altering their habitats. The disturbance of natural habitats affects the diversity of both vertebrates and invertebrates by altering both feeding and nesting sites for which organisms are known to depend on for survival. Little is known of the extent to which vulnerable habitats could shape the diversity of most indigent pollinators such as African meliponine bee species in tropical ecosystems...
2017: International Journal of Insect Science
https://www.readbyqxmd.com/read/28529214/improving-diabetic-retinopathy-in-an-indigent-population
#14
Renee Rosati, Adrienne Z Ables, Petra Warren
Diabetic retinopathy is the leading cause of preventable blindness in working-age American adults. This study hypothesized that patients with diabetes types I and II at St.Luke's Free Medical Clinic in Spartanburg, South Carolina were not being systematically referred for annual diabetic retinopathy screening. We evaluated the number of patients referred for screening, those patients who actually went for the screening, and the rate at which retinopathy was found in those who went. Of the 111 charts reviewed, only 49...
2017: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/28528713/sociodemographics-and-the-impact-of-a-colostomy-to-indigent-families-and-children-with-colorectal-disorders-in-honduras
#15
W Krois, A J M Dingemans, P X Hernández, M L Metzelder, J Craniotis Rios, C A Reck-Burneo
INTRODUCTION: To describe the social impact of a colostomy on indigent families and affected children with anorectal malformations (ARM) or Hirschsprung's disease (HD) in San Pedro Sula, Honduras, we specifically targeted very low-income households that attended an international medical brigade for ARM and HD in 2016. METHODS: The impact of a colostomy on the families and children's daily life was analyzed by personal interviews with a questionnaire. RESULTS: Twenty families with children were included in the study...
May 12, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28495590/concurrent-activation-of-%C3%AE-2-adrenergic-receptor-and-blockage-of-gpr55-disrupts-pro-oncogenic-signaling-in-glioma-cells
#16
Artur Wnorowski, Justyna Such, Rajib K Paul, Robert P Wersto, Fred E Indig, Krzysztof Jozwiak, Michel Bernier, Irving W Wainer
Activation of β2-adrenergic receptor (β2AR) and deorphanized GPR55 has been shown to modulate cancer growth in diverse tumor types in vitro and in xenograft models in vivo. (R,R')-4'-methoxy-1-naphthylfenoterol [(R,R')-MNF] is a bivalent compound that agonizes β2AR but inhibits GPR55-mediated pro-oncogenic responses. Here, we investigated the molecular mechanisms underlying the anti-tumorigenic effects of concurrent β2AR activation and GPR55 blockade in C6 glioma cells using (R,R')-MNF as a marker ligand...
August 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28486027/safety-evaluation-of-an-automated-remote-monitoring-system-for-heart-failure-in-an-urban-indigent-population
#17
Sandra Gross-Schulman, Laura Myerchin Sklaroff, Crystal Coyazo Hertz, Jeffrey J Guterman
Heart Failure (HF) is the most expensive preventable condition, regardless of patient ethnicity, race, socioeconomic status, sex, and insurance status. Remote telemonitoring with timely outpatient care can significantly reduce avoidable HF hospitalizations. Human outreach, the traditional method used for remote monitoring, is effective but costly. Automated systems can potentially provide positive clinical, fiscal, and satisfaction outcomes in chronic disease monitoring. The authors implemented a telephonic HF automated remote monitoring system that utilizes deterministic decision tree logic to identify patients who are at risk of clinical decompensation...
May 9, 2017: Population Health Management
https://www.readbyqxmd.com/read/28479801/management-and-outcome-of-infantile-hydrocephalus-in-a-tertiary-health-institution-in-nigeria
#18
Ayodeji Salman Yusuf, Habeeb Kayodele Omokanye, Nurudeen Abiola Adeleke, Rukeme Oluaseun Akanbi, Sikiru Olalekan Ajiboye, Hakeem Gbadebo Ibrahim
BACKGROUND: Hydrocephalus is a leading cause of disability among children worldwide. The outcome depends on morphology and whether insult is pre- or post-natal. There has been improvement in morbidity in developed countries due to improved surgical care. A paucity of trained personnel impacts negatively on care and outcome of infants with hydrocephalus in many low-income countries resulting poorer outcome. We conducted an audit of patients with hydrocephalus managed in our institution to determine common etiology and outcome...
April 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28372524/the-demographic-characteristics-of-medicolegal-death-among-welfare-recipients-in-tokyo-metropolis-2008-2013
#19
Hideto Suzuki, Takanobu Tanifuji, Nobuyuki Abe, Tatsushige Fukunaga
Background The number of welfare recipients has steadily increased in Japan during recent years, although the number of homeless persons has decreased. Despite there being many reports regarding medicolegal death among homeless persons, medicolegal death among welfare recipients has not been fully investigated. Methods We identified 10,293 individuals who received welfare aid during their lifetime among the 81,867 cases that were examined by the Tokyo Medical Examiner's Office (2008-2013). We retrospectively compared the proportions of medicolegal death to total population, age, sex, family status, clinical history, and manners/causes of death among non-indigent persons (controls), homeless persons, and welfare recipients...
April 2017: Medicine, Science, and the Law
https://www.readbyqxmd.com/read/28366602/clinical-outcomes-of-switching-from-insulin-glargine-to-nph-insulin-in-indigent-patients-at-a-charitable-pharmacy-the-charitable-insulin-nph-care-for-the-indigent-cinci-study
#20
Russell Curington, Mike Espel, Pamela C Heaton, Heidi Luder, Bethanne Brown
OBJECTIVES: To assess the clinical outcomes of indigent patients with type 2 diabetes served by a charitable pharmacy after therapy change from insulin glargine to NPH insulin. DESIGN: This was a 24-week prospective pilot study. SETTING: Community charitable pharmacy. PARTICIPANTS: Underserved, financially disadvantaged adults with type 2 diabetes. INTERVENTION: Conversion from insulin glargine to NPH insulin...
March 30, 2017: Journal of the American Pharmacists Association: JAPhA
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