Karolina Gente, Manuel Feisst, Dorothea Marx, Karel D Klika, Petros Christopoulos, Jürgen Graf, Julia Will, Thomas Luft, Jessica C Hassel, Carsten Müller-Tidow, Rui A Carvalho, Hanns-Martin Lorenz, M Margarida Souto-Carneiro
OBJECTIVES: A timely diagnosis is imperative for curing cancer. However, in patients with rheumatic musculoskeletal diseases (RMDs) or paraneoplastic syndromes, misleading symptoms frequently delay cancer diagnosis. As metabolic remodelling characterises both cancer and RMD, we analysed if a metabolic signature can indicate paraneoplasia (PN) or reveal concomitant cancer in patients with RMD. METHODS: Metabolic alterations in the sera of rheumatoid arthritis (RA) patients with (n=56) or without (n=52) a history of invasive cancer were quantified by nuclear magnetic resonance analysis...
April 1, 2024: Annals of the Rheumatic Diseases