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https://www.readbyqxmd.com/read/28139863/role-of-intrinsic-sphincter-deficiency-with-and-without-urethral-hypomobility-on-the-outcome-of-tape-insertion
#1
Edyta Wlaźlak, Volker Viereck, Jacek Kociszewski, Andrzej Kuszka, Oliver Rautenberg, Claudia Walser, Grzegorz Surkont, Marianne Gamper, Mathias K Fehr
AIMS: Intrinsic sphincter deficiency (ISD) is a known risk factor for therapy failure after tension-free vaginal tape (TVT) insertion. The purpose of this study was to investigate if the severity of ISD alone or other factors such as urethral mobility and tape localization influence outcomes. METHODS: One hundred and nine women with urodynamically determined ISD, a TVT insertion, and a 6-month follow-up visit were included. Urethral length, mobility, and tape localization were evaluated by pelvic floor sonography...
January 31, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28139006/comparison-of-protocols-measuring-diffusion-and-partition-coefficients-in-the-stratum-corneum
#2
H Rothe, C Obringer, J Manwaring, C Avci, W Wargniez, J Eilstein, N Hewitt, R Cubberley, H Duplan, D Lange, C Jacques-Jamin, M Klaric, A Schepky, S Grégoire
Partition (K) and diffusion (D) coefficients are important to measure for the modelling of skin penetration of chemicals through the stratum corneum (SC). We compared the feasibility of three protocols for the testing of 50 chemicals in our main studies, using three cosmetics-relevant model chemicals with a wide range of logP values. Protocol 1: SC concentration-depth profile using tape-stripping (measures KSC/v and DSC /HSC(2) , where HSC is the SC thickness); Protocol 2A: incubation of isolated SC with chemical (direct measurement of KSC/v only) and Protocol 2B: diffusion through isolated SC mounted on a Franz cell (measures KSC/v and DSC /HSC(2) , and is based on Fick's laws)...
January 31, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28126662/on-chip-electrochemical-immunoassay-platform-for-specific-protein-biomarker-estimation-in-undiluted-serum-using-off-surface-membrane-matrix
#3
Sunil K Arya, Patthara Kongsuphol, Mi Kyoung Park
The manuscript presents a new biosensor platform using bioreceptors modified porous 2-dimensional (2D) membrane based off-surface matrix for on-chip electrochemical immunoassay. Antibody based bioreceptors modified 2D matrix of porous polycarbonate (PC) membrane with densely packed 20µm holes as off-surface matrix was incorporated in very close proximity of the sensor surface and integrated with fluidic system for reagent flow and incubation chamber. Covalent attachment of antibodies on 2D PC membrane based off-matrix was achieved using 4-fluoro-3-nitro-azidobenzene (FNAB) cross-linker...
January 18, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28105396/a-solution-doped-polymer-semiconductor-insulator-blend-for-thermoelectrics
#4
David Kiefer, Liyang Yu, Erik Fransson, Andrés Gómez, Daniel Primetzhofer, Aram Amassian, Mariano Campoy-Quiles, Christian Müller
Poly(ethylene oxide) is demonstrated to be a suitable matrix polymer for the solution-doped conjugated polymer poly(3-hexylthiophene). The polarity of the insulator combined with carefully chosen processing conditions permits the fabrication of tens of micrometer-thick films that feature a fine distribution of the F4TCNQ dopant:semiconductor complex. Changes in electrical conductivity from 0.1 to 0.3 S cm(-1) and Seebeck coefficient from 100 to 60 μV K(-1) upon addition of the insulator correlate with an increase in doping efficiency from 20% to 40% for heavily doped ternary blends...
January 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28074570/development-of-the-sbirt-checklist-for-observation-in-real-time-score
#5
Janice A Vendetti, Bonnie G McRee, Frances K Del Boca
BACKGROUND AND AIMS: Screening, Brief Intervention and Referral to Treatment (SBIRT) programs have been implemented widely in medical settings, with little attention focused on how well providers adhere to evidence-based service delivery in everyday practice. The purposes of this paper were to: (1) introduce a flexible, relatively simple methodology, the SBIRT Checklist for Observation in Real-time (SCORe), to assess adherence to evidence-based practice and provide preliminary evidence supporting its criterion validity; and (2) illustrate the feasibility and potential utility of the SCORe by analyzing observations of providers within four large-scale SBIRT programs in the United States...
February 2017: Addiction
https://www.readbyqxmd.com/read/28069155/communicating-with-patients-from-minority-backgrounds-individual-challenges-experienced-by-oncology-health-professionals
#6
Kaaren J Watts, Bettina Meiser, Elvira Zilliacus, Rajneesh Kaur, Mona Taouk, Afaf Girgis, Phyllis Butow, David Goldstein, Sandra Hale, Astrid Perry, Sanchia K Aranda, David W Kissane
PURPOSE: Oncology health professionals (HPs) are increasingly required to care for patients from minority backgrounds. Yet many HPs have not had formal training in how to communicate effectively in culturally diverse settings. More information is needed about the challenges that oncology HPs face in communicating with minority patients to inform the content of formal training programs. This qualitative study aimed to identify oncology nurses' and oncologists' individual experiences and challenges in communicating with patients from minority backgrounds...
February 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/28008987/a-bio-enabled-maximally-mild-layer-by-layer-kapton-surface-modification-approach-for-the-fabrication-of-all-inkjet-printed-flexible-electronic-devices
#7
Yunnan Fang, Jimmy G D Hester, Wenjing Su, Justin H Chow, Suresh K Sitaraman, Manos M Tentzeris
A bio-enabled, environmentally-friendly, and maximally mild layer-by-layer approach has been developed to surface modify inherently hydrophobic Kapton HN substrates to allow for great printability of both water- and organic solvent-based inks thus facilitating the full-inkjet-printing of flexible electronic devices. Different from the traditional Kapton surface modification approaches which are structure-compromising and use harsh conditions to target, and oxidize and/or remove part of, the surface polyimide of Kapton, the present Kapton surface modification approach targeted the surface electric charges borne by its additive particles, and was not only the first to utilize environmentally-friendly clinical biomolecules to build up a thin film of protamine-heparin complex on Kapton, but also the first to be conducted under minimally destructive and maximally mild conditions...
December 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27998691/influence-of-the-skin-barrier-on-the-penetration-of-topically-applied-dexamethasone-probed-by-soft-x-ray-spectromicroscopy
#8
K Yamamoto, A Klossek, R Flesch, F Rancan, M Weigand, I Bykova, M Bechtel, S Ahlberg, A Vogt, U Blume-Peytavi, P Schrade, S Bachmann, S Hedtrich, M Schäfer-Korting, E Rühl
The penetration of dexamethasone into human skin ex vivo is reported. X-ray microscopy is used for label-free probing of the drug and quantification of the local drug concentration with a spatial resolution reaching 70±5 nm. This is accomplished by selective probing the dexamethasone by X-ray absorption. Varying the penetration time between 10 min and 1000 min provides detailed information on the penetration process. In addition, the stratum corneum has been damaged by tape-stripping in order to determine the importance of this barrier regarding temporally resolved drug penetration profiles...
December 17, 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27956654/adapting-and-evaluating-a-rapid-low-cost-method-to-enumerate-flies-in-the-household-setting
#9
Marlene K Wolfe, Holly N Dentz, Beryl Achando, MaryAnne Mureithi, Tim Wolfe, Clair Null, Amy J Pickering
Diarrhea is a leading cause of death among children under 5 years of age worldwide. Flies are important vectors of diarrheal pathogens in settings lacking networked sanitation services. There is no standardized method for measuring fly density in households; many methods are cumbersome and unvalidated. We adapted a rapid, low-cost fly enumeration technique previously developed for industrial settings, the Scudder fly grill, for field use in household settings. We evaluated its performance in comparison to a sticky tape fly trapping method at latrine and food preparation areas among households in rural Kenya...
February 8, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27924913/thermal-alternating-polymer-nanocomposite-tapnc-coating-designed-to-prevent-aerodynamic-insect-fouling
#10
Ilker S Bayer, K Ghokulla Krishnan, Robert Robison, Eric Loth, Douglas H Berry, Thomas E Farrell, Jeffrey D Crouch
Insect residue adhesion to moving surfaces such as turbine blades and aircraft not only causes surface contamination problems but also increases drag on these surfaces. Insect fouling during takeoff, climb and landing can result in increased drag and fuel consumption for aircraft with laminar-flow surfaces. Hence, certain topographical and chemical features of non-wettable surfaces need to be designed properly for preventing insect residue accumulation on surfaces. In this work, we developed a superhydrophobic coating that is able to maintain negligible levels of insect residue after 100 high speed (50 m/s) insect impact events produced in a wind tunnel...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27915190/gunshot-residue-and-brakepads-compositional-and-morphological-considerations-for-forensic-casework
#11
William Tucker, Nick Lucas, Kelsey E Seyfang, K Paul Kirkbride, Rachel S Popelka-Filcoff
Previous research has raised the possibility that automotive brake pads can produce particles that are both compositionally and morphologically similar to gunshot residue (GSR). These studies, published in the early 2000s, coincided with the reduction or removal of unnecessary sources of lead from the automotive industry. The question therefore arises whether modern brake pads might still be a relevant source of 'GSR-like' particles. In the present study, a total of 75 brake pads taken from a range of cars currently on the road in Adelaide, South Australia, were collected from service centres...
November 23, 2016: Forensic Science International
https://www.readbyqxmd.com/read/27897018/-ultrasound-comparison-of-adjustable-single-incision-ajust-and-transobturator-tapes-to-assess-post-operative-fixation-and-function-and-clinical-efficacy
#12
F Farhat, K Švabík, P Hubka, A Martan, J Mašata
OBJECTIVE: The aim of this study was to compare fixation and mobility of adjustable single-incision (Ajust) and standard transobturator midurethral sling (TVT-O) tapes based on postoperative ultrasound monitoring of the position of the tape at rest and at maximal Valsava (tape descent). The hypothesis was that fixation of SIMS Ajust is comparable to that achieved by the standard transobturator midurethral sling. SETTING: Gynecology and Obstetrics Department, GUH and 1st Charles University Prague; Gynecology and Obstetrics Department Masarykova nemocnice Ústí nad Labem...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27894032/clinical-outcomes-in-women-undergoing-laparoscopic-hysteropexy-a-systematic-review
#13
REVIEW
R Nair, K I Nikolopoulos, L S Claydon
OBJECTIVES: To systematically review the current evidence on the anatomic and functional outcomes in women undergoing laparoscopic hysteropexy. STUDY DESIGN: An electronic database search was undertaken (2000-2016). Keywords were: "laparoscopy", "hysteropexy", "cervicopexy", "uterine suspension", "uterosacral plication". References of identified studies as well as abstracts from conferences were considered. We restricted the search to humans, female patients and currently used surgical procedures...
January 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27864988/time-to-question-diabetes-self-management-support-for-arabic-speaking-migrants-exploring-a-new-model-of-care
#14
H Alzubaidi, K Mc Namara, C Browning
AIM: The objective of this study was to explore a new model for diabetes self-management support in Arabic-speaking migrants. METHODS: Two qualitative methods were used: face-to-face semi-structured individual interviews and focus groups. Interviews were audio-taped, transcribed verbatim and coded thematically. Arabic-speaking migrants with Type 2 diabetes were recruited from several primary, secondary and tertiary healthcare settings in metropolitan Melbourne, Australia...
November 16, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27833118/enhanced-critical-current-in-p-doped-bafe2as2-thin-films-on-metal-substrates-arising-from-poorly-aligned-grain-boundaries
#15
Hikaru Sato, Hidenori Hiramatsu, Toshio Kamiya, Hideo Hosono
Thin films of the iron-based superconductor BaFe2(As1-xPx)2 (Ba122:P) were fabricated on polycrystalline metal-tape substrates with two kinds of in-plane grain boundary alignments (well aligned (4°) and poorly aligned (8°)) by pulsed laser deposition. The poorly aligned substrate is not applicable to cuprate-coated conductors because the in-plane alignment >4° results in exponential decay of the critical current density (Jc). The Ba122:P film exhibited higher Jc at 4 K when grown on the poorly aligned substrate than on the well-aligned substrate even though the crystallinity was poorer...
November 11, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27824369/proteomics-profiling-of-interactome-dynamics-by-colocalisation-analysis-cola
#16
Faraz K Mardakheh, Heba Z Sailem, Sandra Kümper, Christopher J Tape, Ryan R McCully, Angela Paul, Sara Anjomani-Virmouni, Claus Jørgensen, George Poulogiannis, Christopher J Marshall, Chris Bakal
Localisation and protein function are intimately linked in eukaryotes, as proteins are localised to specific compartments where they come into proximity of other functionally relevant proteins. Significant co-localisation of two proteins can therefore be indicative of their functional association. We here present COLA, a proteomics based strategy coupled with a bioinformatics framework to detect protein-protein co-localisations on a global scale. COLA reveals functional interactions by matching proteins with significant similarity in their subcellular localisation signatures...
December 20, 2016: Molecular BioSystems
https://www.readbyqxmd.com/read/27805415/determination-of-natural-moisturizing-factors-in-the-skin-raman-microspectroscopy-versus-hplc
#17
S A Koppes, P Kemperman, I Van Tilburg, F Calkoen-Kwa, K A Engebretsen, G J Puppels, P J Caspers, S Kezic
BACKGROUND: Natural moisturizing factor (NMF) is used as genotypic and phenotypic biomarker in diagnostics. This study is a side-to-side comparison of two different methods to determine NMF in atopic dermatitis patients: Raman microspectroscopy and stratum corneum tape stripping followed by HPLC. RESULTS: Measured NMF values were significantly correlated (R(2) = .61; p < .0001), both methods demonstrated a concentration-depth dependence of NMF and reduced NMF levels in the carriers of filaggrin null mutations...
January 19, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27800639/measurement-of-skin-surface-biomakers-by-transdermal-analyses-patch-following-different-in-vivo-models-of-irritation-a-pilot-study
#18
D Falcone, P Spee, K Salk, M Peppelman, P C M van de Kerkhof, P E J van Erp
BACKGROUND/PURPOSE: FibroTx Transdermal Analyses Patch (TAP) is a novel technology for non-invasive measurements of protein biomarkers on the skin surface, in vivo. The aim of this study was to explore the potential of TAP in detecting skin surface biomarkers following mild perturbations, in vivo, using two experimental models: tape stripping, mimicking acute barrier disruption, and histamine iontophoresis, mimicking acute and local inflammation at minimal skin barrier insult. METHODS: Tape stripping and histamine iontophoresis were performed in two separate experiments on the volar forearm of healthy volunteers (n = 27 and n = 10, respectively)...
November 1, 2016: Skin Research and Technology
https://www.readbyqxmd.com/read/27789957/breast-cancer-awareness-and-prevention-behavior-among-women-of-delhi-india-identifying-barriers-to-early-detection
#19
Subhojit Dey, Surabhi Sharma, Arti Mishra, Suneeta Krishnan, Jyotsna Govil, Preet K Dhillon
BACKGROUND: Globally, breast cancer (BC) has become the leading cause of mortality in women. Awareness and early detection can curb the growing burden of BC and are the first step in the battle against BC. The aim of this qualitative study was to explore the awareness and perceived barriers concerning the early detection of BC. METHODS: A total of 20 focus group discussions (FGDs) were conducted during May 2013-March 2014. Pre-existing themes were used to conduct FGDs; each FGD group consisted of an average of ~10 women (aged ≥18-70 years) who came to participate in a BC awareness workshop...
2016: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/27732099/the-development-and-implementation-of-an-electronic-health-record-tool-for-monitoring-metabolic-syndrome-indices-in-patients-with-serious-mental-illness
#20
Ken Nash, Frank Ghinassi, Jaspreet S Brar, Abdulkader Alam, Mary Catherine Bohan, Kalyani Gopalan, Amie Carter, K N Roy Chengappa
OBJECTIVES: 1. A quality performance improvement (QI) project to implement an electronic screening and monitoring tool to record components of the metabolic syndrome (e-MSD) during clinic visits by persons with serious mental illness (SMI). 2. To encourage psychiatrists to use this tool in their documentation. METHODS: Working with the information technology staff, five psychiatrists developed, tested, revised and embedded the e-MSD tool into the medication management document within the electronic health record...
December 0: Clinical Schizophrenia & related Psychoses
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