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https://www.readbyqxmd.com/read/28745140/effect-of-cuo-nanoparticles-on-ammonia-removal-and-eps-secretion-of-canon-sludge-in-the-presence-of-nitrite-suppression
#1
Xiaojing Zhang, Yue Zhou, Nan Zhang, Siyu Zhao, Han Zhang, Hanfei Zhai, Jie Zhang
Completely autotrophic nitrogen removal over nitrite (CANON) process was an innovative technology for nitrogen removal from wastewater. It is necessary to clear the impact of CuO nanoparticles (CuO NPs) on CANON process since the widespread utilize increased their opportunity for entering into wastewater. In this study, the short-term and long-term effects of CuO NPs on the ammonia removal and extracellular polymeric substance (EPS) secretion were analyzed in the presence of nitrite, with the CuO NPs of 0, 5, 10, 20, 50, 100, 200 and 500 mg L(-1), respectively...
July 26, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28743564/evolving-biocatalysis-to-meet-bioeconomy-challenges-and-opportunities
#2
REVIEW
Alessandro Pellis, Sara Cantone, Cynthia Ebert, Lucia Gardossi
The unique selectivity of enzymes, along with their remarkable catalytic activity, constitute powerful tools for transforming renewable feedstock and also for adding value to an array of building blocks and monomers produced by the emerging bio-based chemistry sector. Although some relevant biotransformations run at the ton scale demonstrate the success of biocatalysis in industry, there is still a huge untapped potential of catalytic activities available for targeted valorization of new raw materials, such as waste streams and CO2...
July 22, 2017: New Biotechnology
https://www.readbyqxmd.com/read/28742338/advanced-materials-technologies-and-complex-systems-analyses-emerging-opportunities-to-enhance-urban-water-security
#3
Katherine R Zodrow, Qilin Li, Regina M Buono, Wei Chen, Glenn Daigger, Leonardo Duenas-Osorio, Menachem Elimelech, Xia Huang, Guibin Jiang, Jae-Hong Kim, Bruce E Logan, David L Sedlak, Paul Westerhoff, Pedro J J Alvarez
Innovation in urban water systems is required to address the increasing demand for clean water due to population growth and aggravated water stress caused by water pollution, aging infrastructure, and climate change. Advances in materials science, modular water treatment technologies, and complex systems analyses, coupled with the drive to minimize the energy and environmental footprints of cities, provide new opportunities to ensure a resilient and safe water supply. We present a vision for enhancing efficiency and resiliency of urban water systems and discuss approaches and research needs for overcoming associated implementation challenges...
July 25, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28742281/structured-identification-of-response-options-to-address-environmental-health-risks-at-the-agbogbloshie-electronic-waste-site
#4
Danielle Cazabon, Julius N Fobil, George Essegbey, Niladri Basu
Electronic waste (E-waste) is a growing problem across low- and middle-income countries. Agbogbloshie (Accra, Ghana) is among the world's largest and most notorious e-waste sites, with an increasing number of studies documenting a range of environmental health risks. This study aimed to provide national, regional, and international stakeholders with a summary of expert opinion on the most pressing problems arising from e-waste activities at Agbogbloshie, as well as suggested solutions to address these problems...
July 25, 2017: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/28742126/the-pre-columbian-introduction-and-dispersal-of-algarrobo-prosopis-section-algarobia-in-the-atacama%C3%A2-desert-of-northern-chile
#5
Virginia B McRostie, Eugenia M Gayo, Calogero M Santoro, Ricardo De Pol-Holz, Claudio Latorre
Archaeological and palaeoecological studies throughout the Americas have documented widespread landscape and environmental transformation during the pre-Columbian era. The highly dynamic Formative (or Neolithic) period in northern Chile (ca. 3700-1550 yr BP) brought about the local establishment of agriculture, introduction of new crops (maize, quinoa, manioc, beans, etc.) along with a major population increase, new emergent villages and technological innovations. Even trees such as the Algarrobos (Prosopis section Algarobia) may have been part of this transformation...
2017: PloS One
https://www.readbyqxmd.com/read/28741247/contaminants-of-emerging-concern-a-review-of-new-approach-in-aop-technologies
#6
Maryam Salimi, Ali Esrafili, Mitra Gholami, Ahmad Jonidi Jafari, Roshanak Rezaei Kalantary, Mahdi Farzadkia, Majid Kermani, Hamid Reza Sobhi
The presence of contaminants of emerging concern (CECs) such as pharmaceuticals and personal care products (PPCPs), endocrine-disrupting compounds (EDCs), flame retardants (FRs), pesticides, and artificial sweeteners (ASWs) in the aquatic environments remains a major challenge to the environment and human health. In this review, the classification and occurrence of emerging contaminants in aquatic environments were discussed in detail. It is well documented that CECs are susceptible to poor removal during the conventional wastewater treatment plants, which introduce them back to the environment ranging from nanogram per liter (e...
August 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28740599/biosimilars-imitation-games
#7
EDITORIAL
Hussain Dahodwala, Susan T Sharfstein
Biopharmaceutical sales were at $160 billion in 2016. With many top revenue biopharmaceuticals coming off patent in the next 4 years, there is a tremendous rush by leading biopharmaceutical companies worldwide to launch biosimilar versions of innovator products. However, these protein drugs are extremely difficult to copy. In this viewpoint, we will discuss the various drugs slated to lose patent protection and the challenges in manufacturing these drugs using current technologies. The Food and Drug Administration's regulatory role and definitions of similarity will be discussed, and finally, the scientific challenges in mimicking a protein drug in the current patent- and innovation-driven research field will be considered...
July 13, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28740444/effective-deployment-of-technology-supported-management-of-chronic-respiratory-conditions-a-call-for-stakeholder-engagement
#8
Richard W Costello, Alexandra L Dima, Dermot Ryan, R Andrew McIvor, Kay Boycott, Alison Chisholm, David Price, John D Blakey
BACKGROUND: Healthcare systems are under increasing strain, predominantly due to chronic non-communicable diseases. Connected healthcare technologies are becoming ever more capable and their components cheaper. These innovations could facilitate both self-management and more efficient use of healthcare resources for common respiratory diseases such as asthma and chronic obstructive pulmonary disease. However, newer technologies can only facilitate major changes in practice, and cannot accomplish them in isolation...
2017: Pragmatic and Observational Research
https://www.readbyqxmd.com/read/28740440/haphop-physio-a-computer-game-to-support-cognitive-therapies-in-children
#9
Carolina Rico-Olarte, Diego M López, Santiago Narváez, Charic D Farinango, Peter S Pharow
BACKGROUND: Care and support of children with physical or mental disabilities are accompanied with serious concerns for parents, families, healthcare institutions, schools, and their communities. Recent studies and technological innovations have demonstrated the feasibility of providing therapy and rehabilitation services to children supported by computer games. OBJECTIVE: The aim of this paper is to present HapHop-Physio, an innovative computer game that combines exercise with fun and learning, developed to support cognitive therapies in children...
2017: Psychology Research and Behavior Management
https://www.readbyqxmd.com/read/28738987/evaluation-of-sensor-technology-to-detect-fall-risk-and-prevent-falls-in-acute-care
#10
Patricia Potter, Kelly Allen, Eileen Costantinou, William Dean Klinkenberg, Jill Malen, Traci Norris, Elizabeth O'Connor, Wilhemina Roney, Heidi Hahn Tymkew, Laurie Wolf
BACKGROUND: Sensor technology that dynamically identifies hospitalized patients' fall risk and detects and alerts nurses of high-risk patients' early exits out of bed has potential for reducing fall rates and preventing patient harm. During Phase 1 (August 2014-January 2015) of a previously reported performance improvement project, an innovative depth sensor was evaluated on two inpatient medical units to study fall characteristics. In Phase 2 (April 2015-January 2016), a combined depth and bed sensor system designed to assign patient fall probability, detect patient bed exits, and subsequently prevent falls was evaluated...
August 2017: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/28737444/evolving-patterns-in-a-collaboration-network-of-global-r-d-on-monoclonal-antibodies
#11
Xiangjun Kong, Jian-Bo Wan, Hao Hu, Shibing Su, Yuanjia Hu
We investigated the evolution process of collaborative inter-organizational network of the research and development (R&D) on monoclonal antibody (mAb) over the past 30 years. The annual detection of the collaboration network provides dynamics on network structures and relationship changes among different organizations. Our research showed continuous growth of the network's scale and complexity due to the constant entry of new organizations and the forging of new partnering relationships. The evolving topological features reveal a core-periphery structure that became clearer over time and an increasing heterogeneity within the collaborative mAb R&D network...
July 24, 2017: MAbs
https://www.readbyqxmd.com/read/28737143/optimal-utilization-of-pediatric-computed-tomography-to-minimize-radiation-exposure-what-the-clinician-must-know-s
#12
Natasha Gupta, Lalendra Upreti
The number of computed tomography (CT) scans being done for children all over the world is on the rise ever since the advent of Multi-Detector CT (MDCT). However, CT is a potential source of harmful ionizing radiation, and children are more susceptible to its adverse effects. It is essential for the pediatrician as well as the radiologist to be aware of some important principles and guidelines, by following which, radiation exposure to the child can be minimized to the bare essential. It is important to have knowledge of the valid and justifiable indications of CT for the child, the correct technique of performing the scan, and the new technological innovations now available on modern scanners that help to minimize radiation dose...
July 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28736682/standardized-approach-to-quantitatively-measure-residual-limb-skin-health-in-individuals-with-lower-limb-amputation
#13
Cameron L Rink, Matthew M Wernke, Heather M Powell, Mark Tornero, Surya C Gnyawali, Ryan M Schroeder, Jayne Y Kim, Jeffrey A Denune, Alexander W Albury, Gayle M Gordillo, James M Colvin, Chandan K Sen
Objective: (1) Develop a standardized approach to quantitatively measure residual limb skin health. (2) Report reference residual limb skin health values in people with transtibial and transfemoral amputation. Approach: Residual limb health outcomes in individuals with transtibial (n = 5) and transfemoral (n = 5) amputation were compared to able-limb controls (n = 4) using noninvasive imaging (hyperspectral imaging and laser speckle flowmetry) and probe-based approaches (laser doppler flowmetry, transcutaneous oxygen, transepidermal water loss, surface electrical capacitance)...
July 1, 2017: Advances in Wound Care
https://www.readbyqxmd.com/read/28736487/development-blocks-in-innovation-networks-the-swedish-manufacturing-industry-1970-2007
#14
Josef Taalbi
The notion of development blocks (Dahmén, 1950, 1991) suggests the co-evolution of technologies and industries through complementarities and the overcoming of imbalances. This study proposes and applies a methodology to analyse development blocks empirically. To assess the extent and character of innovational interdependencies between industries the study combines analysis of innovation biographies and statistical network analysis. This is made possible by using data from a newly constructed innovation output database for Sweden...
2017: Journal of Evolutionary Economics
https://www.readbyqxmd.com/read/28736264/mesenchymal-stem-stromal-cell-extracellular-vesicles-from-active-principle-to-next-generation-drug-delivery-system
#15
REVIEW
Barbara Crivelli, Theodora Chlapanidas, Sara Perteghella, Enrico Lucarelli, Luisa Pascucci, Anna Teresa Brini, Ivana Ferrero, Mario Marazzi, Augusto Pessina, Maria Luisa Torre
It has been demonstrated that the biological effector of mesenchymal stem/stromal cells (MSCs) is their secretome, which is composed of a heterogeneous pool of bioactive molecules, partially enclosed in extracellular vesicles (EVs). Therefore, the MSC secretome (including EVs) has been recently proposed as possible alternative to MSC therapy. The secretome can be considered as a protein-based biotechnological product, it is probably safer compared with living/cycling cells, it presents virtually lower tumorigenic risk, and it can be handled, stored and sterilized as an Active Pharmaceutical/Principle Ingredient (API)...
July 20, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28735772/silicon-to-syringe-cryptomarkets-and-disruptive-innovation-in-opioid-supply-chains
#16
Michael Gilbert, Nabarun Dasgupta
Cyptomarkets offer insight into the evolving interplay between online black markets and cartel-based distribution. The types and forms of heroin, fentanyl, and prescription drugs show wide diversification. In this commentary we describe changes in the conceptualizations, technologies and structures of drug supply chains in the 21st Century, with special attention to the role of cryptomarkets as tools, contexts, and drivers of innovation in public health research.
June 24, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28735531/origami-and-kirigami-nanocomposites
#17
Lizhi Xu, Terry C Shyu, Nicholas A Kotov
The arts of origami and kirigami inspired numerous examples of macroscale hierarchical structures with high degree of reconfigurability and multiple functionalities. Extension of kirigami and origami patterning to micro-, meso-, and nano-scales enabled production of nanocomposites with unusual combination of properties, transitioning these techniques to the toolbox of materials design. Various subtractive and additive fabrication techniques applicable to nanocomposites and out-of-plane deformation of patterns enable a technological framework to negotiate often contradictory structural requirements for materials properties...
July 23, 2017: ACS Nano
https://www.readbyqxmd.com/read/28735524/characterization-of-cytoskeleton-features-and-maturation-status-of-cultured-human-ipsc-derived-cardiomyocytes
#18
Christian Zuppinger, George Gibbons, Priyanka Dutta-Passecker, Adrian Segiser, Henriette Most, Thomas M Suter
Recent innovations in stem cell technologies and the availability of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have opened new possibilities for studies and drug testing on human cardiomyocytes in vitro. Still, there are concerns about the precise nature of such 'reprogrammed' cells. We have performed an investigation using immunocytochemistry and confocal microscopy on several cellular features using commercially available hiPSC-CMs. For some selected developmentally regulated or cardiac chamber-specific proteins, we have compared the results from hiPSC-derived cardiomyocytes with freshly isolated, ventricular cardiomyocytes from adult rats...
June 21, 2017: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/28735360/navigating-the-future-of-cardiovascular-drug-development-leveraging-novel-approaches-to-drive-innovation-and-drug-discovery-summary-of-findings-from-the-novel-cardiovascular-therapeutics-conference
#19
REVIEW
Thomas J Povsic, Rob Scott, Kenneth W Mahaffey, Robert Blaustein, Jay M Edelberg, Martin P Lefkowitz, Scott D Solomon, Jonathan C Fox, Kevin E Healy, Aarif Y Khakoo, Douglas W Losordo, Fady I Malik, Brett P Monia, Rusty L Montgomery, Jeffrey Riesmeyer, Gregory G Schwartz, Steven L Zelenkofske, Joseph C Wu, Scott M Wasserman, Matthew T Roe
PURPOSE: The need for novel approaches to cardiovascular drug development served as the impetus to convene an open meeting of experts from the pharmaceutical industry and academia to assess the challenges and develop solutions for drug discovery in cardiovascular disease. METHODS: The Novel Cardiovascular Therapeutics Summit first reviewed recent examples of ongoing or recently completed programs translating basic science observations to targeted drug development, highlighting successes (protein convertase sutilisin/kexin type 9 [PCSK9] and neprilysin inhibition) and targets still under evaluation (cholesteryl ester transfer protein [CETP] inhibition), with the hope of gleaning key lessons to successful drug development in the current era...
July 22, 2017: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/28735153/self-monitoring-systems-for-personalised-health-care-and-lifestyle-surveillance
#20
EDITORIAL
Giuseppe Coppini, Sara Colantonio
The quality of life and individual well-being are universally recognised as key factors in disease prevention. In particular, lifestyle interventions are effective tools for reducing the risk and incidence of major illnesses, such as cardiovascular diseases and metabolic disorders. On the other hand, patient role is progressively shifting from being a passive recipient of care towards being a co-producer of her/his health. In this frame, novel devices and systems able to help individuals in self-evaluation are expected to play a crucial role...
July 19, 2017: Computers in Biology and Medicine
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