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https://www.readbyqxmd.com/read/28938744/an-improved-ivm-method-for-cumulus-oocyte-complexes-from-small-follicles-in-polycystic-ovary-syndrome-patients-enhances-oocyte-competence-and-embryo-yield
#1
F Sánchez, F Lolicato, S Romero, M De Vos, H Van Ranst, G Verheyen, E Anckaert, J E J Smitz
STUDY QUESTION: Are meiotic and developmental competence of human oocytes from small (2-8 mm) antral follicles improved by applying an optimized IVM method involving a prematuration step in presence of C-Type Natriuretic Peptide (CNP) followed by a maturation step in presence of FSH and Amphiregulin (AREG)? SUMMARY ANSWER: A strategy involving prematuration culture (PMC) in the presence of CNP followed by IVM using FSH + AREG increases oocyte maturation potential leading to a higher availability of Day 3 embryos and good-quality blastocysts for single embryo transfer...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938739/sequence-variants-of-khdrbs1-as-high-penetrance-susceptibility-risks-for-primary-ovarian-insufficiency-by-mis-regulating-mrna-alternative-splicing
#2
Binbin Wang, Lin Li, Ying Zhu, Wei Zhang, Xi Wang, Beili Chen, Tengyan Li, Hong Pan, Jing Wang, Kehkooi Kee, Yunxia Cao
STUDY QUESTION: Does a novel heterozygous KHDRBS1 variant, identified using whole-exome sequencing (WES) in two patients with primary ovarian insufficiency (POI) in a pedigree, cause defects in mRNA alternative splicing? SUMMARY ANSWER: The heterozygous variant of KHDRBS1 was confirmed to cause defects in alternative splicing of many genes involved in DNA replication and repair. WHAT IS KNOWN ALREADY: Studies in mice revealed that Khdrbs1 deficient females are subfertile, which manifests as delayed sexual maturity and significantly reduced numbers of secondary and pre-antral follicles...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938494/supercritical-fluid-chromatography-in-natural-product-analysis-an-update
#3
Nora Gibitz Eisath, Sonja Sturm, Hermann Stuppner
The wide chemical diversity of natural products has challenged analysts all over the world and has been a driving force for the development of innovative technologies since decades. In the last years, supercritical fluid chromatography (SFC) has finally emerged from the shadow of liquid chromatography (LC) and gas chromatography (GC) and has become a powerful tool in modern natural product analysis. Whereas in the past the technique had mainly been restricted to a small group of nonpolar compounds, it has largely expanded its suitability in the last years and has demonstrated possibilities without boundaries...
September 22, 2017: Planta Medica
https://www.readbyqxmd.com/read/28937949/international-vision-care-issues-and-approaches
#4
Rohit C Khanna, Srinivas Marmamula, Gullapalli N Rao
Globally, 32.4 million individuals are blind and 191 million have moderate or severe visual impairment (MSVI); 80% of cases of blindness and MSVI are avoidable. However, great efforts are needed to tackle blindness and MSVI, as eye care in most places is delivered in isolation from and without significant integration with general health sectors. Success stories, including control of vitamin A deficiency, onchocerciasis, and trachoma, showed that global partnerships, multisectoral collaboration, public-private partnerships, corporate philanthropy, support from nongovernmental organizations-both local and international-and governments are responsible for the success of these programs...
September 15, 2017: Annual Review of Vision Science
https://www.readbyqxmd.com/read/28937947/wastewater-treatment-by-means-of-thermophilic-aerobic-membrane-reactors-respirometric-tests-and-numerical-models-for-determination-of-stoichiometric-kinetic-parameters
#5
Maria Cristina Collivignarelli, Giorgio Bertanza, Alessandro Abbà, Vincenzo Torretta, Ioannis Anastasios Katsoyiannis
The present work considers the pollution abatement of wastewaters, the efficiency of which is depending on stringent verification of the performance of wastewater treatment plants. This is very important especially given that eExisting wastewater/aqueous waste treatment plants often need to be upgraded in order to improve their performance. The satisfactory operation of biological treatment plants requires appropriate monitoring, and respirometric techniques are needed to determine the kinetic parameters that regulate biological processes...
September 22, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28937662/glucose-responsive-insulin-by-molecular-and-physical-design
#6
Naveed A Bakh, Abel B Cortinas, Michael A Weiss, Robert S Langer, Daniel G Anderson, Zhen Gu, Sanjoy Dutta, Michael S Strano
The concept of a glucose-responsive insulin (GRI) has been a recent objective of diabetes technology. The idea behind the GRI is to create a therapeutic that modulates its potency, concentration or dosing relative to a patient's dynamic glucose concentration, thereby approximating aspects of a normally functioning pancreas. From the perspective of the medicinal chemist, the GRI is also important as a generalized model of a potentially new generation of therapeutics that adjust potency in response to a critical therapeutic marker...
September 22, 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28936855/-investigation-on-supramolecular-mechanism-of-multi-component-overall-control-in-chinese-medicine-controlled-sustained-release-preparation
#7
Yan-Tao Yang, Ye-Qin Tao, Wen-Han Tang, Sen Li, Ji-Lian Shi, Yi-Qun Zhou, Wen-Long Liu, Fu-Yuan He
Controlled sustained-release preparation (CSRP) is a definitely important source of innovative medicines, however, its further researches and development are limited due to the complexity of Chinese medicine (CM) compositions, and a series of unclear key problems like the apparent properties from physical and chemical aspects. Combined with the CM characteristics of the multiple components and synergistic effect, a series of bottleneck problems in the preparation of CSRP were analyzed. Then the mechanism and influences of supermolecular chemical theory in the CSRP about the multiple-components overall-control were explored under the guideline of "overall control, synchronous dissolution" in CSRP, based on the previous explications about supramolecular chemistry theories and with the application of single component precision controlling technologies...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28936854/-thinking-on-development-of-shanxi-astragali-radix-industry
#8
Xue-Mei Qin, Ai-Ping Li, Ke Li, An-Ping Li, Lu-Hong Ning
Shanxi, a traditional production area to produce genuine Astragali Radix of high quality, has experienced major changes in the pattern of resources. This area once accounted for half of Astragali Radix industry, but now only serves as the largest supply area of traditional wild Astragali Radix. Furthermore, the strategic position of Shanxi Astragali Radix industry will become more prominent and more important to economic and social development in face of the diversity of market demands, especially for the strong demands of high-end Astragali Radix...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28936594/transcatheter-aortic-valve-replacement-outcomes-indications-complications-and-innovations
#9
REVIEW
Michael N Young, Ignacio Inglessis
Transcatheter aortic valve replacement (TAVR) has become the standard of care for the treatment of severe aortic stenosis in individuals who are at prohibitive surgical risk and presents a viable alternative to surgery in selected patients who are at high operative risk. To date, outcomes from the PARTNER (Placement of AoRtic TraNscathetER Valve) and Medtronic CoreValve® US Pivotal trials continue to show the benefits of TAVR in these high-risk subgroups out to 5 and 3 years, respectively (as reported by Mack et al...
September 22, 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28936475/surgical-data-science-the-new-knowledge-domain
#10
S Swaroop Vedula, Gregory D Hager
Healthcare in general, and surgery/interventional care in particular, is evolving through rapid advances in technology and increasing complexity of care with the goal of maximizing quality and value of care. While innovations in diagnostic and therapeutic technologies have driven past improvements in quality of surgical care, future transformation in care will be enabled by data. Conventional methodologies, such as registry studies, are limited in their scope for discovery and research, extent and complexity of data, breadth of analytic techniques, and translation or integration of research findings into patient care...
April 2017: Innov Surg Sci
https://www.readbyqxmd.com/read/28936206/an-in-vitro-fermentation-study-on-the-effects-of-gluten-friendly-tm-bread-on-microbiota-and-short-chain-fatty-acids-of-fecal-samples-from-healthy-and-celiac-subjects
#11
Adele Costabile, Triana Bergillos-Meca, Loretta Landriscina, Antonio Bevilacqua, Isidro Gonzalez-Salvador, Maria R Corbo, Leonardo Petruzzi, Milena Sinigaglia, Carmela Lamacchia
Recently, an innovative gluten detoxification method called Gluten Friendly(TM) (GF) has been developed. It induces structural modifications, which abolish the antigenic capacity of gluten and reduce the in vitro immunogenicity of the most common epitopes involved in celiac disease, without compromising the nutritional and technological properties. This study investigated the in vitro effects of GF bread (GFB) on the fecal microbiota from healthy and celiac individuals by a three-stage continuous fermentative system, which simulates the colon (vessel 1, proximal colon; vessel 2, transverse colon; and vessel 3, distal colon), as well as on the production of short chain fatty acids (SCFA, acetate, propionate, butyrate)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28936029/silicon-nanoporous-membranes-as-a-rigorous-platform-for-validation-of-biomolecular-transport-models
#12
Benjamin J Feinberg, Jeff C Hsiao, Jaehyun Park, Andrew L Zydney, William H Fissell, Shuvo Roy
Microelectromechanical systems (MEMS), a technology that resulted from significant innovation in semiconductor fabrication, have recently been applied to the development of silicon nanopore membranes (SNM). In contrast to membranes fabricated from polymeric materials, SNM exhibit slit-shaped pores, monodisperse pore size, constant surface porosity, zero pore overlap, and sub-micron thickness. This development in membrane fabrication is applied herein for the validation of the XDLVO (extended Derjaguin, Landau, Verwey, and Overbeek) theory of membrane transport within the context of hemofiltration...
August 15, 2017: Journal of Membrane Science
https://www.readbyqxmd.com/read/28934987/lifestyle-precision-medicine-the-next-generation-in-type-2-diabetes-prevention
#13
REVIEW
Pascal M Mutie, Giuseppe N Giordano, Paul W Franks
The driving force behind the current global type 2 diabetes epidemic is insulin resistance in overweight and obese individuals. Dietary factors, physical inactivity, and sedentary behaviors are the major modifiable risk factors for obesity. Nevertheless, many overweight/obese people do not develop diabetes and lifestyle interventions focused on weight loss and diabetes prevention are often ineffective. Traditionally, chronically elevated blood glucose concentrations have been the hallmark of diabetes; however, many individuals will either remain 'prediabetic' or regress to normoglycemia...
September 22, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28934295/the-lithic-assemblages-of-donggutuo-nihewan-basin-knapping-skills-of-early-pleistocene-hominins-in-north-china
#14
Shi-Xia Yang, Michael D Petraglia, Ya-Mei Hou, Jian-Ping Yue, Cheng-Long Deng, Ri-Xiang Zhu
Donggutuo (DGT) is one of the richest archaeological localities in the Nihewan Basin of North China, thereby providing key information about the technological behaviours of early hominins in eastern Asia. Although DGT has been subject of multiple excavations and technological studies over the past several decades, few detailed studies on the lithic assemblages have been published. Here we summarize and describe the DGT lithic assemblages, examining stone tool reduction methods and technological skills. DGT dates to ca...
2017: PloS One
https://www.readbyqxmd.com/read/28934169/function-oriented-molecular-design-dendrimers-as-novel-antimicrobials
#15
REVIEW
Sandra García-Gallego, Gianluigi Franci, Annarita Falanga, Rafael Gómez, Veronica Folliero, Stefania Galdiero, Francisco Javier de la Mata, Massimiliano Galdiero
In recent years innovative nanostructures are attracting increasing interest and, among them, dendrimers have shown several fields of application. Dendrimers can be designed and modified in plentiful ways giving rise to hundreds of different molecules with specific characteristics and functionalities. Biomedicine is probably the field where these molecules find extraordinary applicability, and this is probably due to their multi-valency and to the fact that several other chemicals can be coupled to them to obtain desired compounds...
September 21, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28933813/facile-and-effective-coloration-of-dye-inert-carbon-fiber-fabrics-with-tunable-colours-and-excellent-laundering-durability
#16
Fengxiang Chen, Huiyu Yang, Ke Li, Bo Deng, Qingsong Li, Xin Liu, Binghai Dong, Xingfang Xiao, Dong Wang, Yong Qin, Shi-Min Wang, Ke-Qin Zhang, Weilin Xu
Carbon fiber is a good candidate in various applications, including military, structural, sports equipment, energy storage, and infrastructure. Coloring of carbon fiber has been a big challenge for decades due to their high degrees of crystallization and insufficient chemical affinity to dyes. Here, multicolored carbon fiber fabrics (CFFs) are fabricated using a feasible, effective atomic layer deposition (ALD) technique. The vibrant and uniform structural colors originate from thin film interference is simply regulated by controlling the thickness of comformal TiO2 coatings on the surface of black carbon fibers (CFs)...
September 21, 2017: ACS Nano
https://www.readbyqxmd.com/read/28933795/microfluidic-production-of-nanoscale-perfluorocarbon-droplets-as-liquid-contrast-agents-for-ultrasound-imaging
#17
Xiaonan Xu, Ruyuan Song, Minghao He, Chuan Peng, Miao Yu, Youmin Hou, Huihe Qiu, Ruhai Zou, Shuhuai Yao
Liquid perfluorocarbon (PFC) nanodroplets may have a better chance to extravasate through inter-endothelial gaps (400-800 nm) into tumor interstitium for extravascular imaging, which holds promise as an innovative strategy for imaging-guided drug delivery, early diagnosis of cancer and minimally invasive treatment of cancer. Currently available emulsion technologies still face challenges in reducing droplet sizes from the microscale to the nanoscale. To control size and ensure monodispersity of PFC nanodroplets, we developed a flame-shaped glass capillary and polydimethylsiloxane (PDMS) hybrid device that creates a concentric flow of the dispersed phase enclosed by the focusing continuous phase at the cross-junction...
September 21, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28933412/genetic-substrate-reduction-therapy-a-promising-approach-for-lysosomal-storage-disorders
#18
REVIEW
Maria Francisca Coutinho, Juliana Inês Santos, Liliana Matos, Sandra Alves
Lysosomal storage diseases are a group of rare genetic disorders characterized by the accumulation of storage molecules in late endosomes/lysosomes. Most of them result from mutations in genes encoding for the catabolic enzymes that ensure intralysosomal digestion. Conventional therapeutic options include enzyme replacement therapy, an approach targeting the functional loss of the enzyme by injection of a recombinant one. Even though this is successful for some diseases, it is mostly effective for peripheral manifestations and has no impact on neuropathology...
November 9, 2016: Diseases (Basel)
https://www.readbyqxmd.com/read/28933205/mass-spectrometry-methods-to-study-protein-metabolite-interactions
#19
Hongbo Guo, Hui Peng, Andrew Emili
To ​​​​understand and manipulate biochemical processes and signaling pathways, the knowledge of endogenous protein-metabolite interactions would be extremely helpful. Recent developments in precision mass spectrometry, high-throughput proteomics and sensitive metabolomic profiling are beginning to converge on a possible solution, heralding a new era of global metabolome-proteome 'interactome' studies that promise to change biomedical research and drug discovery. Areas covered: Here, we review innovative mass spectrometry-based methods and recent pioneering studies aimed at elucidating the physical associations of small molecule ligands with cellular proteins...
September 21, 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/28933102/-resources-industrialization-channels-and-strategies-of-active-polysaccharide-from-lycii-fructus-based-on-analysis-of-domestic-and-foreign-intellectual-properties
#20
REVIEW
Fang Zhang, Sheng Guo, Da-Wei Qian, Xia Zhang, Xiao-Chun Yang, Yong-Jing Li, Jin-Ao Duan
Lycii Fructus is a traditional medicinal and edible herb, with the function of liver and kidney nourishing, blood and eyesight replenishing. As the most important active substance in the fruits of Lycium barbarum, Lycium barbarum polysaccharides (LBP) have been demonstrated to play multiple pharmacological activities, with broad prospects for development and utilization. Based on the comprehensive deep analysis of global LBP patent output, the current patent LBP features were explored from the perspective of development trend, technology field distribution, time dimension, technology life curve and patent applicant...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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