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https://www.readbyqxmd.com/read/28109209/nostoc-thermotolerans-sp-nov-a-soil-dwelling-species-of-nostoc-cyanobacteria-isolated-from-madhya-pradesh-india
#1
Archana Suradkar, Chelsea Villanueva, Lira A Gaysina, Dale A Casamatta, Aniket Saraf, Gandhali Dighe, Ratnaprabha Mergu, Prashant Singh
A filamentous, soil dwelling cyanobacterial strain (9C-PS) was isolated from Mandsaur, Madhya Pradesh, India and is being described as new species of Nostoc. Extensive morphological and molecular characterization along with thorough assessment of ecology was performed. The style of filament orientation, type and nature of the sheath (e.g., distribution and visibility across the trichome), and vegetative and heterocyte cell dimensions and shape were assessed for more than a year employing both culture and naturally occurring samples...
January 19, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28109208/psychromonas-aquatilis-sp-nov-isolated-from-water-samples-obtained-in-the-chilean-antarctica
#2
Peter Kämpfer, Rute Irgang, Mathías Poblete-Morales, Stefanie P Glaeser, Marcelo Cortez-San Martín, Ruben Avendaño-Herrera
One slightly beige-white pigmented, Gram-staining negative, rod-shaped bacterium, strain M1A1T, was isolated from seawater samples obtained in Fildes Bay, Antarctica (62º12´S, 58º57´W). Phylogenetic analysis based on nearly full-length 16S rRNA gene sequences showed that the isolate shared 98.4 % 16S rRNA gene sequence identity to the type strain of the species Psychromonas arctica, but less than 97 % 16S rRNA gene sequence similarities to all other Psychromonas species. DNA-DNA hybridisation (DDH) with Psychromonas arctica DSM 14288T showed low values (21 %, reciprocal 27 %)...
January 19, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28109203/pedobacter-lusitanus-sp-nov-a-new-bacterial-species-isolated-from-sludge-of-a-deactivated-uranium-mine-in-portugal
#3
Cláudia Covas, Tânia Caetano, Andreia Cruz, Tiago Santos, Liliana Dias, Guenter Klein, Amir Abdulmawjood, Luiz Rodríguez-Alcalá, Lígia Pimentel, Ana Gomes, Ana Cristina Freitas, Alba Garcia-Serrano, Javier Fontecha, Sónia Mendo
Strain NL19T is a Gram negative aerobic bacterium that was isolated from sludge of a deactivated uranium mine in Portugal. 16S rRNA gene sequence analysis revealed that strain NL19T is a member of the genus Pedobacter and closely related to the strains Pedobacter himalayensis MTCC 6384T, Pedobacter cryoconitis DSM 14825T, Pedobacter westerhofensis DSM 19036T and P. hartonius DSM 19033T. It has a DNA G+C content of 40.8 mol%, which agreed with the genus description. The main fatty acids include C16:1 9c, C14:1 9c, C4:0, Iso-C17:0, Iso-C17:0 3-OH, C16:0, Anteiso-C15:0 and Iso-C15:0 3-OH...
January 21, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28109200/arcobacter-lekithochrous-sp-nov-a-new-species-isolated-from-a-molluscan-hatchery-in-norway
#4
Ana L Diéguez, Sabela Balboa, Thorolf Magnesen, Jesús L Romalde
Four bacterial strains, LFT 1.7T, LT2C 2.5, LT4C 2.8 and TM 4.6, were isolated from Great scallop (Pecten maximus) larvae and tank seawater in a Norwegian hatchery and characterized by a polyphasic approach including phenotypic, chemotaxonomic and genomic traits. All of them were Gram-negative and motile rods, oxidase and catalase positive and required sea salts for growth. Major fatty acids present were Summed Feature 3 (C16:1ω7c/C16:1 ω6c), Summed Feature 8 (C18:1ω7c or C18:1 ω6c), C16:0, C14:0, Summed Feature 2 (C14:0 3OH/C16:1 iso I), C12:0 3OH and C12:0...
January 19, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28109155/-preparation-and-application-of-rabbit-anti-mouse-setd8-polyclonal-antibody
#5
Haitao Ma, Jiaqian Guo, Jing Xia, Changmin Niu, Xueyi Shen, Hongya Sun, Ying Zheng
Objective To purify the recombinant Setd8 protein and prepare rabbit anti-mouse Setd8 polyclonal antibody. Methods The recombinant plasmid pET-30a-Setd8 was constructed by double enzyme digestion and linkage, and then transformed into E.coli BL21. The expression of the target protein was induced by IPTG and the expression product was purified by Ni-NTA affinity chromatograph. The purified protein was used to immunize New Zealand white rabbits to produce polyclonal antibody. The titer and specificity of the antibody were identified by ELISA, Western blotting and immunohistochemistry...
February 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28109123/sodium-butyrate-protects-against-high-fat-diet-induced-cardiac-dysfunction-and-metabolic-disorders-in-type-ii-diabetic-mice
#6
Ling Zhang, Jianfeng Du, Naohiro Yano, Hao Wang, Yu Tina Zhao, Dubielecka-Szczerba Patricia, Shougang Zhuang, Eugene Y Chin, Gangjian Qin, Ting C Zhao
Histone deacetylases are recently identified to act as key regulators for cardiac pathophysiology and metabolic disorders. However, the function of histone deacetylase (HDAC) in controlling cardiac performance in type II diabetes and obesity remains unknown. Here we determine whether HDAC inhibition attenuates high fat diet (HFD)-induced cardiac dysfunction and improves metabolic features. Adult mice were fed with either HFD or standard chow food for 24 weeks. Starting at 12 weeks, mice were divided into four groups randomly, in which sodium butyrate (1%), a potent HDAC inhibitor, was provided to chow and HFD-fed mice in drinking water, respectively...
January 21, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28109086/grade-dependent-expression-of-nima-related-kinase-2-in-glioma-and-its-cellular-upregulatory-activity-on-proliferation-and-invasion
#7
Li Tian, Peng Cheng, Huaiyu Sun, Yulin Wang, Lei Zhang, Zongze Guo
Glioma is one of the most common tumors in central nervous system. The median life expectancy for glioma patients is only 13-15 months. NIMA-related expressed kinase 2 (NEK2) is a kind of serine-threonine kinases and involves in carcinogenesis and progression of cancer, however, the specific roles in the glioma remains unknown. We found the high expression of NEK2 was positively correlated with deteriorated severity of glioma. Therefore, we sought to investigate the effects of NEK2 on U87 and U251 cells. To explore the expression of NEK2 and alteration of signaling pathway factors, qRT-PCR and Western blot analysis were performed...
January 20, 2017: Oncology Research
https://www.readbyqxmd.com/read/28109078/3-phosphoinositide-dependent-protein-kinase-1-pdk-1-promotes-migration-and-invasion-in-gastric-cancer-cells-through-activating-the-nf-%C3%AE%C2%BAb-pathway
#8
Ning Wu, Changyu He, Bohui Zhu, Jinling Jiang, Yiwen Chen, Tao Ma
Gastric cancer (GC) is one of the most common cancers and the second leading cause of cancer deaths in the world. Manyfactors were reported involving the progression and development of GC. In this study, we aimed to investigate the correlation of 3-phosphoinositide dependent protein kinase 1 (PDK-1) with cell viability, cell migration, and cell invasion of GC. The expression of PDK-1 was measured in different GC cell lines. Thereafter, the expression of PDK-1 was interfered by small hairpin RNA (shRNA) and then incubated with or without the inhibitor of NF-κB pyrrolidine dithiocarbamate (PDTC)...
January 20, 2017: Oncology Research
https://www.readbyqxmd.com/read/28109052/the-use-of-methadone-to-facilitate-opioid-weaning-in-pediatric-critical-care-patients-a-systematic-review-of-the-literature-and-meta-analysis
#9
REVIEW
Leslie A Dervan, Beryl Yaghmai, Robert Scott Watson, Fredric M Wolf
BACKGROUND: Continuous opioid infusion therapy is commonly utilized in the pediatric intensive care setting to treat pain and facilitate tolerance of invasive therapies. Transitioning to methadone is one common strategy for weaning from continuous opioid infusions, but in practice this transition can be challenging, and many children still experience iatrogenic withdrawal. AIM: We reviewed the literature to evaluate the best available evidence to guide methadone therapy in this setting, and to summarize associated adverse events...
January 20, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28109043/angiographic-assessment-of-aortic-regurgitation-by-video-densitometry-in-the-setting-of-tavi-echocardiographic-and-clinical-correlates
#10
Mohammad Abdelghani, Hiroki Tateishi, Yosuke Miyazaki, Rafael Cavalcante, Osama I I Soliman, Jan G Tijssen, Robbert J de Winter, Jan Baan, Yoshinobu Onuma, Carlos M Campos, Rogério S Leite, José A Mangione, Alexandre Abizaid, Pedro A Lemos, Fabio S de Brito, Patrick W Serruys
OBJECTIVES: We sought to investigate a new angiographic method for aortic regurgitation (AR) severity assessment in the setting of transcatheter aortic valve implantation (TAVI). BACKGROUND: AR after TAVI is common but challenging to quantitate, especially in the cath-lab. METHODS: In 228 patients, AR was quantitated before and after TAVI by echocardiography and by video-densitometric analysis of aortograms. Contrast time-density curves for the aortic root (the reference region) and the left ventricular outflow tract, LVOT were generated...
January 21, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28109039/nkx2-5-regulates-endothelin-converting-enzyme-1-during-pharyngeal-arch-patterning
#11
Jennifer M Iklé, Andre L P Tavares, Marisol King, Hailei Ding, Sophie Colombo, Beth A Firulli, Anthony B Fiulli, Kimara L Targoff, Deborah Yelon, David E Clouthier
In gnathostomes, dorsoventral (D-V) patterning of neural crest cells (NCC) within the pharyngeal arches is crucial for the development of hinged jaws. One of the key signals that mediates this process is Endothelin-1 (EDN1). Loss of EDN1 binding to the Endothelin-A receptor (EDNRA) results in loss of EDNRA signaling and subsequent facial birth defects in humans, mice and zebrafish. A rate-limiting step in this crucial signaling pathway is the conversion of immature EDN1 into a mature active form by Endothelin converting enzyme-1 (ECE1)...
January 20, 2017: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/28109037/a-new-strategy-for-development-of-anti-thrombotic-agents-inhibition-of-the-c-terminal-active-site-of-pdi
#12
L Wang, D W Essex
Protein disulfide isomerase (PDI) was discovered over fifty years ago as an enzyme that forms disulfide bonds in newly synthesized proteins in the endoplasmic reticulum [1]. Twenty five years ago PDI was shown to be released from activated platelets [2] opening up a new field of research on extracellular functions of this enzyme. PDI was subsequently localized to the platelet surface [3] and shown to mediate platelet aggregation [4, 5]. This article is protected by copyright. All rights reserved.
January 21, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28109025/immune-regulation-by-t-regulatory-cells-in-hbv-related-inflammation-and-cancer
#13
REVIEW
Nirupama Trehanpati, Ashish Kumar Vyas
Hepatocellular carcinoma (HCC) is the leading cause of cancer death and hepatitis B virus (HBV) infection is one of the commonest causes in Asians countries. India has the second largest pool after China for hepatitis B infected subjects. HBV clearance is T cell dependent and one of the reason for T cells hypo responsiveness is due to mass production of Tregs through activation of Notch signaling, which suppressCD4/CD8 T cells. Regulatory T cells (Tregs) are important to maintain cellular homeostasis; however during viral infection increase of Tregs is inversely proportional to HBV DNA titers...
January 21, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28109024/computer-assisted-technologies-used-in-oral-rehabilitation-and-the-clinical-documentation-of-alleged-advantages-a-systematic-review
#14
REVIEW
Asbjørn Jokstad
The objective of this systematic review is to identify current computer-assisted technologies used for managing patients with a need to re-establish craniofacial appearance, subjective discomfort and stomatognathic function, and the extent of their clinical documentation. Electronic search strategies were used for locating clinical studies in MEDLINE through PubMed and in the Cochrane library, and in the grey literature through searches on Google Scholar. The searches for commercial digital products for use in oral rehabilitation resulted in identifying 225 products per November 2016, used for patient diagnostics, communication and therapy purposes, and for other computer-assisted applications in context with oral rehabilitation...
January 21, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28109001/polygonum-multiflorum-radix-extract-protects-human-foreskin-melanocytes-from-oxidative-stress-in-vitro-and-potentiates-hair-follicle-pigmentation-ex-vivo
#15
Peggy Sextius, Richard Betts, Ishak Benkhalifa, Stéphane Commo, Joan Eilstein, Marco Massironi, Ping Wang, Jean-Francois Michelet, Jie Qiu, Xuezhu Tan, Severine Jeulin
OBJECTIVE: To examine the ability of an extract from traditional Chinese medicine, Polygonum multiflorum Radix, to protect melanocyte viability from oxidative stress, a key mechanism in the initiation and progression of hair greying. METHODS: To assess the antioxidant capacity of Polygonum multiflorum Radix extract, primary human foreskin melanocytes were treated with a commercially available Polygonum multiflorum Radix extract added to culture medium and exposed to hydrogen peroxide (H2 O2 ), using intracellular reactive oxygen species concentrations and glutathione/protein ratios as endpoints...
January 20, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/28108993/experience-from-a-multi-country-initiative-to-improve-the-monitoring-of-selected-reproductive-health-indicators-in-africa
#16
Maria Barreix, Özge Tunçalp, Namuunda Mutombo, Ayotunde A Adegboyega, Lale Say
Universal access to sexual and reproductive health remains part of the unfinished business of global development in the Africa. To achieve it, health interventions should be monitored using programmatic indicators. WHO's Strengthening Measurement of Reproductive Health Indicators in Africa initiative, implemented in Ghana, Nigeria, Kenya, Uganda, and Zimbabwe, aimed to improve national information systems for routine monitoring of reproductive health indicators. Participating countries developed action plans employing a two-pronged strategy: (1) revising, standardizing, and harmonizing existing information-system reproductive health indicators; and (2) building data-collection capacity through training and supervision at select pilot sites...
January 21, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28108989/tigit-signaling-pathway-negatively-regulates-cd4-t-cell-responses-in-systemic-lupus-erythematosus
#17
Lie Mao, Hongyan Hou, Shiji Wu, Yu Zhou, Juan Wang, Jing Yu, Xiaohui Wu, Yanfang Lu, Liyan Mao, Munyemana Jean Bosco, Feng Wang, Ziyong Sun
B lymphocyte hyperactivity in systemic lupus erythematosus (SLE) is T cell-dependent, and CD4(+) T cell activation is essential to SLE pathogenesis. However, the mechanism of the deregulation of CD4(+) T cells in SLE is largely unknown. T-cell immunoglobulin and ITIM domain (TIGIT) is a new inhibitory receptor preferentially expressed on activated CD4(+) T cells. Here, we addressed the role of TIGIT in the pathogenesis of SLE. Our results showed that TIGIT expression on CD4(+) T cells was significantly elevated in patients with SLE and highly correlated with the activity of the disease...
January 20, 2017: Immunology
https://www.readbyqxmd.com/read/28108987/activation-of-sirt1-by-human-chorionic-gonadotropin-exerts-a-therapeutic-effect-on-hepatic-injury-and-inflammation
#18
Caroline Steinmetz, Anubha Kashyap, Nataliya Zhivkova, Henry Alizor, Isabell Ernst, Daniela Gottfried-Brand, Henning Janssen, Andreas Teufel, Henning Schulze-Bergkamen, Johannes Lotz, Jürgen Kuball, Matthias Theobald, Michael Heise, Hauke Lang, Peter R Galle, Dennis Strand, Susanne Strand
: The incidence and prevalence of inflammatory liver diseases has increased over the last years but therapeutic options are limited. Pregnancy induces a state of immune tolerance, which can result in spontaneous improvement of clinical symptoms of certain autoimmune diseases including autoimmune hepatitis (AIH). We investigated the immune suppressive mechanisms of the human pregnancy hormone chorionic gonadotropin (hCG) in the liver. HCG signaling activates SIRT1, which deacetylates FOXO3a, leading to repression of pro-apoptotic gene expression...
January 21, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28108977/a-locus-coeruleus-norepinephrine-account-of-individual-differences-in-working-memory-capacity-and-attention-control
#19
Nash Unsworth, Matthew K Robison
Studies examining individual differences in working memory capacity (WMC) have suggested that low WMC individuals have particular deficits in attention control processes compared to high WMC individuals. In the current article we suggest that part of the WMC-attention control relation is due to variation in the functioning of the locus coeruleus-norepinephrine system (LC-NE). Specifically, we suggest that because of dysregulation of LC-NE functioning, the fronto-parietal control network for low WMC individuals is only weakly activated, resulting in greater default-mode network activity (and greater mind-wandering) for low WMC individuals compared to high WMC individuals...
January 20, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28108967/specific-sites-of-metastases-in-invasive-lobular-carcinoma-a-retrospective-cohort-study-of-metastatic-breast-cancer
#20
Masayuki Inoue, Hiroshi Nakagomi, Haruka Nakada, Kazushige Furuya, Kou Ikegame, Hideki Watanabe, Masao Omata, Toshio Oyama
BACKGROUND: Invasive lobular carcinoma (ILC) is known to be the second most common histological type following invasive ductal carcinoma (IDC). Definitive clinical features of ILC are controversial. METHODS: We retrospectively analyzed a cohort of 330 patients with metastatic breast cancer, 303 of IDC, 19 of ILC, and 8 of others. We compared the patient age and tumor-node-metastasis factors, disease-free survival (DFS), estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 (HER2) expression at the primary site between ILC and IDC...
January 20, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
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