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Nitric Oxide

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https://www.readbyqxmd.com/read/28350760/involvement-of-hsp70-and-ho-1-in-the-protective-effects-of-raloxifene-on-multiple-organ-dysfunction-syndrome-by-endotoxemia-in-ovariectomized-rats
#1
Hsin-Hsueh Shen, Shieh-Yang Huang, Pao-Yun Cheng, Yen-Ju Chu, Shu-Ying Chen, Kwok-Keung Lam, Yen-Mei Lee
OBJECTIVE: Accumulating evidence demonstrates that raloxifene, a selective estrogen receptor modulator, possesses anti-inflammatory action. This study evaluates the preventive effects of long-term treatment of raloxifene on acute inflammation and multiple organ dysfunction syndrome (MODS) in ovariectomized (OVX) rats with endotoxemia and its underlying mechanism of action. METHODS: Adult female rats were OVX bilaterally to induce estrogen insufficiency. OVX rats were administered with raloxifene (1 mg/kg, gavage, once daily) for 8 weeks, beginning 1 week after surgery, followed by induction of sepsis via intravenous infusion of lipopolysaccharides (LPS; 30 mg/kg) for 4 hours...
March 27, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28350536/anti-inflammatory-effects-and-anti-oxidant-capacity-of-myrathius-arboreus-cecropiaceae-in-experimental-models
#2
Oluwafemi Gabriel Oluwole, Olufunmilayo Ologe, Akinyinka Alabi, Ganiyu Tunde Yusuf, Solomon Umukoro
BACKGROUND: Inflammation is involved in various diseases; search for safe treatments is warranted. Anti-inflammatory effects of ethanol extract of Myrathius arboreus (EEMa) were studied in carrageenan-induced model, formaldehyde sub-acute-induced model, and in 48 h lipopolysaccharide-induced air pouch model of inflammation. EEMa membrane-stabilizing activities and anti-oxidant capacity were determined in vitro. METHODS: In the carrageenan model EEMa (125, 250, or 500 mg/kg), indomethacin (5 mg/kg), or vehicle 3 mL/kg was administered orally in rats (n=5)...
March 28, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28346955/nonischemic-priapism-in-childhood-a-case-series-and-review-of-literature
#3
Hans-Walter Hacker, Marcus G Schwoebel, Philipp O Szavay
Introduction Nonischemic priapism (NIP) in childhood is a very rare affection. In the literature, patients with NIP are described mainly incidental after perineal trauma. Many of them underwent embolization of either internal pudendal artery or bulbocavernosal arteries. Patients and Methods We report on six boys between 4 and 13 years of age with NIP, treated at our institution between 2008 and 2014. Color Doppler ultrasound (CDU) was performed in all patients as emergency diagnostic evaluation. Patients were treated conservatively, including bed rest, local cooling, and perineal compression...
March 27, 2017: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28346888/oxidative-and-nitrosative-stress-biomarkers-in-chronic-schizophrenia
#4
Karine Maria Boll, Cristiano Noto, Kamila Landucci Bonifácio, Chiara Cristina Bortolasci, Ary Gadelha, Rodrigo Affonseca Bressan, Décio Sabbatini Barbosa, Michael Maes, Estefania Gastaldello Moreira
There is evidence that the acute phase of schizophrenia (SCZ) is accompanied by specific changes in oxidative and nitrosative stress (O&NS) biomarkers. There are, however, no firm data regarding these biomarkers in chronic SCZ. Therefore, this study aimed to delineate O&NS biomarkers in patients with chronic SCZ. 125 outpatients with SCZ and 118 controls were enrolled. The markers included lipid hydroperoxides (LOOH), advanced oxidation protein products (AOPP), nitric oxide metabolites (NOx), total radical-trapping antioxidant parameter (TRAP) and paraoxonase 1 (PON-1) activity...
March 21, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28346478/association-of-enos-and-cav-1-gene-polymorphisms-with-susceptibility-risk-of-large-artery-atherosclerotic-stroke
#5
Hann-Yeh Shyu, Ming-Hua Chen, Yi-Hsien Hsieh, Jia-Ching Shieh, Ling-Rong Yen, Hsiao-Wei Wang, Chun-Wen Cheng
Endothelial nitric oxide synthase (eNOS) is localized in caveole and has important effects on caveolar coordination through its interaction with caveolin-1 (Cav-1), which supports normal functioning of vascular endothelial cells. However, the relationship between genotypic polymorphisms of e-NOS and Cav-1 genes and ischemic stroke (IS) remains lesser reported. This hospital-based case-control study aimed to determine the genetic polymorphisms of the eNOS (Glu298Asp) and Cav-1 (G14713A and T29107A) genes in association with susceptibility risk in patients who had suffered from a large artery atherosclerotic (LAA) stroke...
2017: PloS One
https://www.readbyqxmd.com/read/28346142/the-neuropeptide-f-nitric-oxide-pathway-is-essential-for-shaping-locomotor-plasticity-underlying-locust-phase-transition
#6
Li Hou, Pengcheng Yang, Feng Jiang, Qing Liu, Xianhui Wang, Le Kang
Behavioral plasticity is widespread in swarming animals, however little is known about its underlying neural and molecular mechanisms. Here, we report that a neuropeptide F (NPF)/nitric oxide (NO) pathway plays a critical role in the locomotor plasticity of swarming migratory locusts. Two related neuropeptides, NPF1a and NPF2, show reduced levels of their encoding transcripts during crowding, and the transcript levels of their receptors significantly increase during locust isolation. Both of these NPFs have suppressive effects on phase-related locomotor activity...
March 27, 2017: ELife
https://www.readbyqxmd.com/read/28345897/a-smart-molecule-for-selective-sensing-of-nitric-oxide-conversion-of-no-to-hsno-relevance-of-biological-hsno-formation
#7
Abu Saleh Musha Islam, Rahul Bhowmick, Kaberi Pal, Atul Katarkar, Keya Chaudhuri, Mahammad Ali
A smart molecule, QT490, containing thiosemicarbazide moiety acts as a highly selective turn-on in vitro NO sensor through the unprecedented NO-induced transformation of thiosemicarbazide moiety to 1,3,4-oxadiazole heterocycle with the concomitant release of HSNO, thereby eliminating any interference from various endogenous biomolecules including dehydroascorbic acid, ascorbic acid, etc. The kinetic studies of the reactions between QT490 and NO provide a mechanistic insight into formation of HSNO/RSNO from the reaction between H2S/RSH and NO in the biological system...
March 27, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28345551/biliverdin-protects-the-isolated-rat-lungs-from-ischemia-reperfusion-injury-via-antioxidative-anti-inflammatory-and-anti-apoptotic-effects
#8
Wen-Fang Tian, Ping Weng, Qiong Sheng, Jun-Liang Chen, Peng Zhang, Ji-Ru Zhang, Bin Du, Min-Chen Wu, Qing-Feng Pang, Jian-Jun Chu
BACKGROUND: Biliverdin (BV) has a protective role against ischemia-reperfusion injury (IRI). However, the protective role and potential mechanisms of BV on lung IRI (LIRI) remain to be elucidated. Thus, we aimed to investigate the protective role and potential mechanisms of BV on LIRI. METHODS: Lungs were isolated from Sprague-Dawley rats to establish an ex vivo LIRI model. After an initial 15 min stabilization period, the isolated lungs were subjected to ischemia for 60 min, followed by 90 min of reperfusion with or without BV treatment...
April 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28345531/polyphenols-in-preventing-endothelial-dysfunction
#9
Sylwia Biegańska-Hensoldt, Danuta Rosołowska-Huszcz
One of the main causes of mortality in developed countries is atherosclerosis. The pathogenesis of atherosclerosis is associated with endothelial dysfunction. Consumption of food rich in natural antioxidants including polyphenols significantly improves endothelial cells functions. Polyphenols have a beneficial effect on the human body and play an important part in protecting the cardiovascular system. Polyphenols present in food have antioxidant, anti-inflammatory, antihypertensive, antithrombotic and antiproliferative properties...
March 27, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28345393/inhibitory-effects-of-3%C3%AE-hydroxy-lup-20-29-en-23-28-dioic-acid-on-lipopolysaccharide-induced-tnf-%C3%AE-il-1%C3%AE-and-the-high-mobility-group-box-1-release-in-macrophages
#10
Xiang-Qian Liu, Qin-Peng Zou, Jian-Jun Huang, Chang-Soo Yook, Wan-Kyunn Whang, Hyeong-Kyu Lee, Ok-Kyoung Kwon
We investigated the anti-inflammatory effects of 3α-hydroxy-lup-20(29)-en-23, 28-dioic acid (HLEDA)-a lupane-type triterpene isolated from leaves of Acanthopanax gracilistylus W. W.Smith (AGS), as well as the underlying molecular mechanisms in lipopolysaccharide (LPS)-induced RAW264.7 cells. Our results demonstrated that HLEDA concentration-dependently reduced the production of nitric oxide (NO), significantly suppressed LPS-induced expression of TNF-α and IL-1β at the mRNA and protein levels in RAW264...
March 27, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28345149/t-vaginalis-exosome-like-vesicles-modify-the-cytokine-profile-and-reduce-inflammation-in-parasite-infected-mice
#11
Luis Mario Olmos-Ortiz, Marco Barajas-Mendiola, Miriam Barrios-Rodiles, Laura E Castellano, Sergio Arias-Negrete, Eva E Avila, Patricia Cuéllar-Mata
Trichomonas vaginalis (Tv) is a flagellated parasite commonly spread through sexual transmission. This protozoan initiates a severe inflammatory process, inducing nitric oxide, interleukin-6 (IL-6), IL-8, IL-10, IL-17, and IL-22 production by host immune cells. The parasites elicit these responses by releasing surface lipophosphoglycan, small extracellular vesicles (exosomes) and other factors. Tv exosomes are similar to mammalian exosomes and have been implicated in the modulation of IL-8 secretion by epithelial cells...
March 27, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28345095/a-simple-functional-carbon-nanotube-fiber-for-in-vivo-monitoring-of-no-in-a-rat-brain-following-cerebral-ischemia
#12
Li Liu, Limin Zhang, Zhihui Dai, Yang Tian
Nitric oxide (NO) is key free-radical messenger and neuronal signal which is closely related to many brain diseases. It is a challenge to develop a sensitive and reliable biosensor for in vivo monitoring of NO in the brain. In this research, a simple ratiometric electrochemical biosensor for NO monitoring in rat brain following cerebral ischemia was developed using a carbon nanotube fiber (CNF) modified with hemin, in which the CNF not only served as a platform to assemble the hemin molecule, but greatly facilitated the electron transfer of hemin on to the electrode surface...
March 27, 2017: Analyst
https://www.readbyqxmd.com/read/28344787/allele-specific-transcriptional-activity-of-the-variable-number-of-tandem-repeats-of-the-inducible-nitric-oxide-synthase-gene-is-associated-with-idiopathic-achalasia
#13
Giovanni Sarnelli, Michela Grosso, Ilaria Palumbo, Marcella Pesce, Alessandra D'Alessandro, Giovanni Zaninotto, Vito Annese, Raffaella Petruzzelli, Paola Izzo, Rossana Sepulveres, Dario Bruzzese, Giuseppe Esposito, Rosario Cuomo
BACKGROUND: Polymorphisms of genes involved in the regulation of the immune response are risk factors for achalasia, but their contribution to disease pathogenesis is unknown. Nitric oxide is involved both in immune function and inhibitory neurotransmission. OBJECTIVE: The objective of this article is to assess the association and the functional relevance of the CCTTT-inducible nitric oxide synthase (NOS2) gene promoter polymorphism in achalasia. METHODS: Genomic DNA was isolated from 181 achalasia patients and 220 controls...
March 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28344594/articular-inflammation-induced-by-an-enzymatically-inactive-lys49-phospholipase-a2-activation-of-endogenous-phospholipases-contributes-to-the-pronociceptive-effect
#14
Renata Gonçalves Dias, Sandra Coccuzzo Sampaio, Morena Brazil Sant'Anna, Fernando Queiroz Cunha, José María Gutiérrez, Bruno Lomonte, Yara Cury, Gisele Picolo
BACKGROUND: Arthritis is a set of inflammatory conditions that induce aching, stiffness, swelling, pain and may cause functional disability with severe consequences to the patient's lives. These are multi-mediated pathologies that cannot be effectively protected and/or treated. Therefore, the aim of this study was to establish a new model of acute arthritis, using a Lys49-PLA2 (Bothrops asper myotoxin II; MT-II) to induce articular inflammation. METHODS: The articular inflammation was induced by MT-II (10 μg/joint) injection into the left tibio-tarsal or femoral-tibial-patellar joints...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28344560/nitric-oxide-has-a-concentration-dependent-effect-on-the-cell-cycle-acting-via-ein2-in-arabidopsis-thaliana-cultured-cells
#15
Galina V Novikova, Luis A J Mur, Alexander V Nosov, Artem A Fomenkov, Kirill S Mironov, Anna S Mamaeva, Evgeny S Shilov, Victor Y Rakitin, Michael A Hall
Ethylene is known to influence the cell cycle (CC) via poorly characterized roles whilst nitric oxide (NO) has well-established roles in the animal CC but analogous role(s) have not been reported for plants. As NO and ethylene signaling events often interact we examined their role in CC in cultured cells derived from Arabidopsis thaliana wild-type (Col-0) plants and from ethylene-insensitive mutant ein2-1 plants. Both NO and ethylene were produced mainly during the first 5 days of the sub-cultivation period corresponding to the period of active cell division...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28344559/cyclooxygenase-2-inhibition-limits-angiotensin-ii-induced-dna-oxidation-and-protein-nitration-in-humans
#16
Vincent Pialoux, Marc J Poulin, Brenda R Hemmelgarn, Daniel A Muruve, Erica N Chirico, Camille Faes, Darlene Y Sola, Sofia B Ahmed
Compared to other cyclooxygenase-2 inhibitors, celecoxib is associated with a lower cardiovascular risk, though the mechanism remains unclear. Angiotensin II is an important mediator of oxidative stress in the pathophysiology of vascular disease. Cyclooxygenase-2 may modify the effects of angiotensin II though this has never been studied in humans. The purpose of the study was to test the effects of selective cyclooxygenase-2 inhibition on plasma measures of oxidative stress, the vasoconstrictor endothelin-1, and nitric oxide metabolites, both at baseline and in respose to Angiotensin II challenge in healthy humans...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28344377/effect-of-nitrogen-compounds-on-transport-of-ruthenium-through-the-rcs
#17
Ivan Kajan, Teemu Kärkelä, Ari Auvinen, Christian Ekberg
Ruthenium is a fission product that can be released from the fuel in case of a severe nuclear accident. In this work the impact of the atmosphere composition, including air radiolysis products, on the transport of ruthenium through a primary circuit was examined. Experiments were performed at temperatures 1300, 1500 and 1700 K in a slightly humid air. In the experiments significant effect of nitrogen oxides (N2O, NO2) and nitric acid on the ruthenium chemistry in the model primary circuit was observed. The obtained results indicate a strong effect of air radiolysis products on the quantity partitioning of transported ruthenium to gaseous and aerosol compounds...
2017: Journal of Radioanalytical and Nuclear Chemistry
https://www.readbyqxmd.com/read/28344207/dipeptidyl-peptidase-iv-inhibition-for-the-treatment-of-cardiovascular-disease%C3%A3-recent-insights-focusing-on-angiogenesis-and-neovascularization
#18
Yanna Lei, Lina Hu, Guang Yang, Limei Piao, Minggen Jin, Xianwu Cheng
Dipeptidyl peptidase IV (DPP-IV) is a complex enzyme that acts as a membrane-anchored cell surface exopeptidase and transmits intracellular signals through a small intracellular tail. DPP-IV exists in human blood in a soluble form, and truncates a large number of peptide hormones, chemokines, cytokines, and growth factors in vitro and in vivo. DPP-IV has gained considerable interest as a therapeutic target, and a variety of DPP-IV inhibitors that prolong the insulinotropic effects of glucagon-like peptide-1 (GLP-1) are widely used in clinical settings as antidiabetic drugs...
March 25, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28344126/regulation-of-the-nitric-oxide-oxidase-activity-of-myeloperoxidase-by-pharmacological-agents
#19
Sophie L Maiocchi, Jonathan C Morris, Martin D Rees, Shane R Thomas
The leukocyte-derived heme enzyme myeloperoxidase (MPO) is released extracellularly during inflammation and impairs nitric oxide (NO) bioavailability by directly oxidizing NO or producing NO-consuming substrate radicals. Here, structurally diverse pharmacological agents with activities as MPO substrates/inhibitors or antioxidants were screened for their effects on MPO NO oxidase activity in human plasma and physiological model systems containing endogenous MPO substrates/antioxidants (tyrosine, urate, ascorbate)...
March 23, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28344103/evaluation-of-geranylgeranylacetone-against-cisplatin-induced-ototoxicity-by-auditory-brainstem-response-heat-shock-proteins-and-oxidative-levels-in-guinea-pigs
#20
Wu-Chia Lo, Chen-Tu Wu, Hillary Chiao Lee, Yi-Ho Young, Yih-Leong Chang, Po-Wen Cheng
This study aims to assess whether geranylgeranylacetone (GGA) could reduce ototoxicity induced by cisplatin through upregulation of not only heat shock protein(HSP)-70, but also HSP-27 and HSP-40, and to study if GGA would reduce cisplatin-induced increase in oxidative stress. 48 guinea pigs were used in this study and treated with the following regimen: 0.5% CMC (sodium carboxymethyl cellulose) control for 7days, GGA (600mg/kg/d) for 7days, a combination of GGA (600mg/kg) for 7days and then one dose of 10mg/kg cisplatin (GGA+Cis), and a combination of CMC for 7days and then 10mg/kg cisplatin (cisplatin group)...
March 24, 2017: Neurotoxicology and Teratology
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