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REVIEW
Marco Alveal, Andrea Méndez, Aline García, Mauricio Henríquez
Purinergic signaling is a crucial determinant in the regulation of pulmonary vascular physiology and presents a promising avenue for addressing lung diseases. This intricate signaling system encompasses two primary receptor classes: P1 and P2 receptors. P1 receptors selectively bind adenosine, while P2 receptors exhibit an affinity for ATP, ADP, UTP, and UDP. Functionally, P1 receptors are associated with vasodilation, while P2 receptors mediate vasoconstriction, particularly in basally relaxed vessels, through modulation of intracellular Ca2+ levels...
May 7, 2024: Purinergic Signalling
#2
JOURNAL ARTICLE
Solomon Owumi, Harieme Agbarogi, Bayode J Oluwawibe, Moses T Otunla, Mayowa M Anifowose, Uche O Arunsi
Sodium fluoride (NaF) ingestion has several detrimental effects in humans and rodents. NaF mechanisms of toxicity include perturbation of intracellular redox homeostasis and apoptosis. Betaine (BET) is a modified amino acid with anti-inflammatory, antioxidant, and anti-apoptotic properties. This study investigates BET's effect on NaF-induced hepatorenal toxicities in rats. Experimental rats (n = 30) were randomly assigned to groups (n = 6) and treated by gavage for 28 days. Group I (2 mL of distilled water), Group II (NaF: 9 mg/kg) alone, Group III: (BET: 100 mg/kg), Group IV: (NaF: 9 mg/kg and BET 1: 50 mg/kg), and Group V: (NaF: 9 mg/kg and BET 2: 100 mg/kg)...
May 7, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
#3
JOURNAL ARTICLE
Olivera Mitrović-Ajtić, Emilija Živković, Tijana Subotički, Miloš Diklić, Dragoslava Đikić, Milica Vukotić, Teodora Dragojević, Vojin Vuković, Darko Antić, Vladan P Čokić
Chronic inflammation has been identified in leukemias as an essential regulator of angiogenesis. B-chronic lymphocytic leukemia (CLL) cells secrete high levels of vascular endothelial growth factor (VEGF) and hypoxia inducible factor 1 alpha (HIF1α). The aim was to assess the role of inflammation in activation of angiogenic factors: endothelial nitric oxide synthase (eNOS), HIF1α and VEGF via proliferation related signaling pathways and VEGF autocrine control. We isolated mononuclear cells (MNC) and CD19+ cells from peripheral blood of 60 patients with CLL...
May 7, 2024: Annals of Hematology
#4
JOURNAL ARTICLE
D D Pozdnyakova, T А Bakhareva, I A Baranova, V D Selemir, A G Chuchalin
UNLABELLED: Рost-COVID-19 syndrome (PS) is one of the medical and social problem. According to WHO, 10-20% of COVID-19 patients suffer from PS. The use of medical gases - inhaled nitric oxide (iNO) and molecular hydrogen (iH2 ) - may influence on the mechanisms of development PC. AIM: To evaluate the safety and efficacy of the combined inhalation of NO and H2 (iNO/iH2 ) in patients with respiratory manifestations of PS. MATERIALS AND METHODS: 34 patients with PS (11 men/23 women, 60...
April 16, 2024: Terapevticheskiĭ Arkhiv
#5
JOURNAL ARTICLE
G R Sergeeva, A V Emelyanov
AIM: To assess effectiveness and safety of biological therapy in patients with severe asthma during 5 yr follow-up. MATERIALS AND METHODS: We recruited 129 adult outpatients (29% males) aged 18-81 yrs with severe asthma were followed up during 5 yrs and were examined for every 3-6 months. Eighty five patients were treated by conventional therapy (ICS/LABA ± tiotropium, montelukast, OCS) only and 44 pts additionally received biologicals (оmalizumab - 9 pts, мepolizumab - 8 pts, benralizumab - 11 pts, dupilumab - 16 pts)...
April 16, 2024: Terapevticheskiĭ Arkhiv
#6
JOURNAL ARTICLE
Jamaira Aparecida Victorio, Letícia Barssotti, Tamar Aprahamian, Raul Gobato Costa, Felippe Mousovich-Neto, Helena Coutinho Franco de Oliveira, Marcelo Mori, Luciana Venturini Rossoni, Ana Paula Davel
Long-term β-adrenoceptor (β-AR) stimulation is a pathological mechanism associated with cardiovascular diseases resulting in endothelial and perivascular adipose tissue (PVAT) dysfunction. In this study, we aimed to identify whether β-adrenergic signaling has a direct effect on PVAT. Thoracic aorta PVAT was obtained from male Wistar rats and cultured ex vivo with the β-AR agonist isoproterenol (Iso; 1 µM) or vehicle for 24 hours. Conditioned culture medium (CCM) from Iso-treated PVAT induced a marked increase in aorta contractile response, induced oxidative stress and reduced nitric oxide production in PVAT compared to vehicle...
May 7, 2024: Endocrinology
#7
JOURNAL ARTICLE
Kiuanne Lino Lobo Metzker, Khiany Mathias, Richard Simon Machado, Sandra Bonfante, Larissa Joaquim, Marina Goulart da Silva, Guilherme Cabreira Daros, Elisa Mitkus Flores Lins, Fernanda Belle, Carolina Giassi Alano, Rafaela Tezza Matiola, Isabela da Silva Lemos, Lucinéia Gainski Danielski, Fernanda Frederico Gava, Rafael Mariano de Bitencourt, Franciane Bobinski, Emilio Luiz Streck, Gislaine Zilli Reus, Fabricia Petronilho
BACKGROUND: In response to inflammation and other stressors, tryptophan is catalyzed by Tryptophan 2,3-Dioxygenase (TDO), which leads to activation of the kynurenine pathway. Sepsis is a serious condition in which the body responds improperly to an infection, and the brain is the inflammation target in this condition. OBJECTIVE: This study aimed to determine if the induction of TDO contributes to the permeability of the Blood-Brain Barrier (BBB), mortality, neuroinflammation, oxidative stress, and mitochondrial dysfunction, besides long-term behavioral alterations in a preclinical model of sepsis...
May 6, 2024: CNS & Neurological Disorders Drug Targets
#8
REVIEW
Samridhi Lakhanpal, Kanishk Aggarwal, Harmanjit Kaur, Kunal Kanwar, Vasu Gupta, Jill Bhavsar, Rohit Jain
Inflammatory bowel disease (IBD) is a spectrum of diseases characterized by the interplay of the aberrant immune system, genetic factors, environmental factors, and intestinal microbiota, resulting in relapsing inflammation of the gastrointestinal tract. Underlying pro-inflammatory state and immune dysregulation act as a catalyst for increasing the likelihood of developing extraintestinal manifestations, including cardiovascular diseases (CVD) like atherosclerosis, pericarditis, myocarditis, venous and arterial thromboembolism, arrhythmias, despite a lower prevalence of classic CVD risk factors, like high body mass index or dyslipidemia compared to the general population...
May 7, 2024: Intestinal Research
#9
Shenyu Zhai, Shintaro Otsuka, Jian Xu, Vernon R J Clarke, Tatiana Tkatch, David Wokosin, Zhong Xie, Asami Tanimura, Hitesh K Agarwal, Graham C R Ellis-Davies, Anis Contractor, D James Surmeier
Long-term synaptic plasticity at glutamatergic synapses on striatal spiny projection neurons (SPNs) is central to learning goal-directed behaviors and habits. Although considerable attention has been paid to the mechanisms underlying synaptic strengthening and new learning, little scrutiny has been given to those involved in the attenuation of synaptic strength that attends suppression of a previously learned association. Our studies revealed a novel, non-Hebbian, long-term, postsynaptic depression of glutamatergic SPN synapses induced by interneuronal nitric oxide (NO) signaling (NO-LTD) that was preferentially engaged at quiescent synapses...
April 25, 2024: bioRxiv
#10
JOURNAL ARTICLE
Khaled Saeed Yousef Al Baloushi, Annadurai Senthilkumar, Karthishwaran Kandhan, Radhakrishnan Subramanian, Jaleel Kizhakkayil, Tholkappiyan Ramachandran, Safa Shehab, Shyam Sreedhara Kurup, Mohammed Abdul Muhsen Alyafei, Ayesha Salem Al Dhaheri, Abdul Jaleel
INTRODUCTION: The synthesis of nanoparticles using naturally occurring reagents such as vitamins, sugars, plant extracts, biodegradable polymers and microorganisms as reductants and capping agents could be considered attractive for nanotechnology. These syntheses have led to the fabrication of limited number of inorganic nanoparticles. Among the reagents mentioned above, plant-based materials seem to be the best candidates, and they are suitable for large-scale biosynthesis of nanoparticles...
2024: International Journal of Nanomedicine
#11
MULTICENTER STUDY
Celeste M Porsbjerg, John Townend, Celine Bergeron, George C Christoff, Gregory P Katsoulotos, Désirée Larenas-Linnemann, Trung N Tran, Riyad Al-Lehebi, Sinthia Z Bosnic-Anticevich, John Busby, Mark Hew, Konstantinos Kostikas, Nikolaos G Papadopoulos, Paul E Pfeffer, Todor A Popov, Chin Kook Rhee, Mohsen Sadatsafavi, Ming-Ju Tsai, Charlotte Suppli Ulrik, Mona Al-Ahmad, Alan Altraja, Aaron Beastall, Lakmini Bulathsinhala, Victoria Carter, Borja G Cosio, Kirsty Fletton, Susanne Hansen, Liam G Heaney, Richard B Hubbard, Piotr Kuna, Ruth B Murray, Tatsuya Nagano, Laura Pini, Diana Jimena Cano Rosales, Florence Schleich, Michael E Wechsler, Rita Amaral, Arnaud Bourdin, Guy G Brusselle, Wenjia Chen, Li Ping Chung, Eve Denton, Joao A Fonseca, Flavia Hoyte, David J Jackson, Rohit Katial, Bruce J Kirenga, Mariko Siyue Koh, Agnieszka Ławkiedraj, Lauri Lehtimäki, Mei Fong Liew, Bassam Mahboub, Neil Martin, Andrew N Menzies-Gow, Pee Hwee Pang, Andriana I Papaioannou, Pujan H Patel, Luis Perez-De-Llano, Matthew J Peters, Luisa Ricciardi, Bellanid Rodríguez-Cáceres, Ivan Solarte, Tunn Ren Tay, Carlos A Torres-Duque, Eileen Wang, Martina Zappa, John Abisheganaden, Karin Dahl Assing, Richard W Costello, Peter G Gibson, Enrico Heffler, Jorge Máspero, Stefania Nicola, Diahn-Warng Perng Steve, Francesca Puggioni, Sundeep Salvi, Chau-Chyun Sheu, Concetta Sirena, Camille Taillé, Tze Lee Tan, Leif Bjermer, Giorgio Walter Canonica, Takashi Iwanaga, Libardo Jiménez-Maldonado, Christian Taube, Luisa Brussino, David B Price
BACKGROUND: To date, studies investigating the association between pre-biologic biomarker levels and post-biologic outcomes have been limited to single biomarkers and assessment of biologic efficacy from structured clinical trials. AIM: To elucidate the associations of pre-biologic individual biomarker levels or their combinations with pre-to-post biologic changes in asthma outcomes in real-life. METHODS: This was a registry-based, cohort study using data from 23 countries, which shared data with the International Severe Asthma Registry (May 2017-February 2023)...
2024: Frontiers in Immunology
#12
JOURNAL ARTICLE
Süleyman Oktar, Mahinur Karadeniz, Musa Acar, İsmail Zararsız
The toxic effect of ethanol on the cerebral cortex and protective effects of omega-3 fatty acids against this neurotoxicity were investigated. Twenty eight male Wistar-albino rats were divided into 4 groups. Rats of the ethanol and ethanol withdrawal groups were treated with ethanol (6 g/kg/day) for 15 days. Animals of the ethanol+omega-3 group received omega-3 fatty acids (400 mg/kg daily) and ethanol. In rats of the ethanol group SOD activity was lower than in animals of the control group. In rats treated with omega-3 fatty acids along with ethanol SOD, activity increased...
April 2024: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
#13
JOURNAL ARTICLE
S Priya, Sheela Berchmans
Our research demonstrates the effectiveness of fluorescence quenching between polyethyleneimine functionalised carbon dots (PEI-CDs) and cyclodextrin encapsulated ferrocene for fluorogenic detection of nitric oxide (NO). We confirmed that ferrocene can be used as a NO probe by observing its ability to quench the fluorescence emitted from PEI-CDs, with NO concentrations ranging from 1 × 10-6 M to 5 × 10-4 M. The photoluminescence intensity (PL) of PEI-CDs decreased linearly, with a detection limit of 500 nM...
May 6, 2024: Scientific Reports
#14
JOURNAL ARTICLE
Maryam Samsamikor, Dylan S Mackay, Rebecca C Mollard, Adeola M Alashi, Rotimi E Aluko
BACKGROUND: The effects of consuming hemp seed protein (HSP) as well as its hydrolysate-derived bioactive peptide (HSP+) on blood pressure (BP) has not to our knowledge been investigated in humans. OBJECTIVE: We aimed to investigate how consumption of HSP and its hydrolysate modulates 24-hr systolic and diastolic BP (24-hrSBP and 24-hrDBP) and plasma biomarkers of BP compared to casein. DESIGN: In a double-blind, randomized, cross-over design trial, 35 adults who had mild hypertension with SBP between 130 and 160 millimeters of mercury (mmHg), and DBP ≤110 mmHg were recruited...
May 4, 2024: American Journal of Clinical Nutrition
#15
JOURNAL ARTICLE
R Reçica, I Kryeziu, Q Thaçi, D Avtanski, M Mladenov, M Basholli-Salihu, R B Sopi
Oxygen therapy provides an important treatment for preterm and low-birth-weight neonates, however, it has been shown that prolonged exposure to high levels of oxygen (hyperoxia) is one of the factors contributing to the development of bronchopulmonary dysplasia (BPD) by inducing lung injury and airway hyperreactivity. There is no effective therapy against the adverse effects of hyperoxia. Therefore, this study was undertaken to test the hypothesis that natural phytoalexin resveratrol will overcome hyperoxia-induced airway hyperreactivity, oxidative stress, and lung inflammation...
April 30, 2024: Physiological Research
#16
JOURNAL ARTICLE
Qi Ye, Juyeon Jo, Chih-Yen Wang, Heavin Oh, Jiangshan Zhan, Tiffany J Choy, Kyoung In Kim, Angelo D'Alessandro, Yana K Reshetnyak, Sung Yun Jung, Zheng Chen, Sean P Marrelli, Hyun Kyoung Lee
Astrocytes play vital roles in blood-brain barrier (BBB) maintenance, yet how they support BBB integrity under normal or pathological conditions remains poorly defined. Recent evidence suggests that ion homeostasis is a cellular mechanism important for BBB integrity. In the current study, we investigated the function of an astrocyte-specific pH regulator, Slc4a4, in BBB maintenance and repair. We show that astrocytic Slc4a4 is required for normal astrocyte morphological complexity and BBB function. Multi-omics analyses identified increased astrocytic secretion of CCL2 coupled with dysregulated arginine-NO metabolism after Slc4a4 deletion...
May 5, 2024: Cell Reports
#17
JOURNAL ARTICLE
Jie Zhang, Xin Xie, Tingsheng Qin, Hualiang Yao, Zhen Ling, Fengyuan Deng, Xiaoyang Yue, Linhong He
Nitric oxide (NO), the smallest signaling molecule known, can be excessively produced by overexpressed inducible nitric oxide synthase (iNOS), and eventually leads to multiple inflammatory related diseases. Thus, reducing the overexpression of NO represents as very potential anti-inflammatory strategy. In current study, a series of compounds were designed and synthesized based on the hybridization of 7H-pyrrolo[2,3-d]pyrimidine and cinnamamide fragments in order to develop novel NO production inhibitors. Among them, compound S2h displayed a vigorous inhibitory activity on NO production with an IC50 value of 3...
May 6, 2024: Molecular Diversity
#18
JOURNAL ARTICLE
Mazhar Hussain, Arslan Hafeez, Muhammad Rizwan, Rizwan Rasheed, Mahmoud F Seleiman, Muhammad Arslan Ashraf, Shafaqat Ali, Umer Farooq, Muhammad Nafees
Hesperidin (HSP), a flavonoid, is a potent antioxidant, metal chelator, mediator of signaling pathways, and regulator of metal uptake in plants. The study examined the ameliorative effects of HSP (100 μM) on Bassia scoparia grown under excessive levels of heavy metals (zinc (500 mg kg-1 ), copper (400 mg kg-1 ), cadmium (100 mg kg-1 ), and chromium (100 mg kg-1 )). The study clarifies the underlying mechanisms by which HSP lessens metabolic mayhem to enhance metal stress tolerance and phytoremediation efficiency of Bassia scoparia...
May 6, 2024: Environmental Science and Pollution Research International
#19
JOURNAL ARTICLE
Nidhi Kandhol, Padmaja Rai, Vipul Mishra, Sangeeta Pandey, Santosh Kumar, Rupesh Deshmukh, Shivesh Sharma, Vijay Pratap Singh, Durgesh Kumar Tripathi
Silicon application mitigates phosphate deficiency in barley through an interplay with auxin and nitric oxide, enhancing growth, photosynthesis, and redox balance, highlighting the potential of silicon as a fertilizer for overcoming nutritional stresses. Silicon (Si) is reported to attenuate nutritional stresses in plants, but studies on the effect of Si application to plants grown under phosphate (Pi) deficiency are still very scarce, especially in barley. Therefore, the present work was undertaken to investigate the potential role of Si in mitigating the adverse impacts of Pi deficiency in barley Hordeum vulgare L...
May 6, 2024: Planta
#20
JOURNAL ARTICLE
Chao Liang, Zhenpeng Song, XiaoZhi Yao, Qian Xiao, Hehui Fu, Lixu Tang
Endothelial dysfunction is crucial factor to the hypertension occurrence, and controversy remains regarding the effect of exercise on improving endothelial function in hypertensive patients. The authors used meta-analysis to evaluate the intervention effect of exercise on endothelial function in hypertensive patients and to investigate exercise protocols that may have a greater intervention effect. A total of 37 studies and a total of 2801 participants were included. The results were as follows: endogenous nitric oxide (NO)[SMD = ...
May 6, 2024: Journal of Clinical Hypertension
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