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https://www.readbyqxmd.com/read/27918936/promoting-angiogenesis-with-mesoporous-microcarriers-through-a-synergistic-action-of-delivered-silicon-ion-and-vegf
#1
Khandmaa Dashnyam, Guang-Zhen Jin, Joong-Hyun Kim, Roman Perez, Jun-Hyeog Jang, Hae-Won Kim
Angiogenic capacity of biomaterials is a key asset to drive vascular ingrowth during tissue repair and regeneration. Here we design a unique angiogenic microcarrier based on sol-gel derived mesoporous silica. The microspheres offer a potential angiogenic stimulator, Si ion, 'intrinsically' within the chemical structure. Furthermore, the highly mesoporous nature allows the loading and release of angiogenic growth factor 'extrinsically'. The Si ion is released from the microcarriers at therapeutic ranges (over a few ppm per day), which indeed up-regulates the expression of hypoxia inducing factor 1α (HIF1α) and stabilizes it by blocking HIF-prolyl hydroxylase 2 (PHD2) in HUVECs...
November 28, 2016: Biomaterials
https://www.readbyqxmd.com/read/27916465/hypoxia-inhibits-lymphatic-thoracic-duct-formation-in-zebrafish
#2
Isabelle Ernens, Andrew I Lumley, Lu Zhang, Yvan Devaux, Daniel R Wagner
Hypoxia promotes blood vessel growth through up-regulation of pro-angiogenic pathways but its role on the lymphatic system remains unclear. The homeobox transcription factor Prox1 is a master control gene for generating lymphatic endothelial cells (LECs) and is up-regulated by hypoxia-inducible factors in mammals. While vascular endothelial growth factor A (VEGFA) is critical for angiogenesis, VEGFC and its receptor VEGF receptor-3 (VEGFR-3) are essential for the initial sprouting and directed migration as well as for the subsequent survival of LECs...
December 1, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27905347/an-interesting-case-of-angiogenesis-in-cavernous-hemangioma
#3
Dipankar Das, Kasturi Bhattacharjee, Panna Deka, Harsha Bhattacharjee, Diva Kant Misra, Akanksha Koul, Deepika Kapoor, Apurba Deka
Cavernous hemangioma is the most common orbital tumor in adult. There is lot of literatures for clinicopathological features of this tumor. These tumors had been studied for the model of angiogenesis in many of the experimental setups. We present a case of 34-year-old male with this tumor in the left eye with computerized tomography evidence. Postsurgical laboratory findings gave interesting evidence of tumor angiogenesis with tumor endothelial cells and sprouting of the small vessels endothelial cells. Podosome rosette could be conceptualized from the characteristic patterns seen in the tumor...
October 2016: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/27898394/mef2-transcription-factors-are-key-regulators-of-sprouting-angiogenesis
#4
Natalia Sacilotto, Kira M Chouliaras, Leonid L Nikitenko, Yao Wei Lu, Martin Fritzsche, Marsha D Wallace, Svanhild Nornes, Fernando García-Moreno, Sophie Payne, Esther Bridges, Ke Liu, Daniel Biggs, Indrika Ratnayaka, Shane P Herbert, Zoltán Molnár, Adrian L Harris, Benjamin Davies, Gareth L Bond, George Bou-Gharios, John J Schwarz, Sarah De Val
Angiogenesis, the fundamental process by which new blood vessels form from existing ones, depends on precise spatial and temporal gene expression within specific compartments of the endothelium. However, the molecular links between proangiogenic signals and downstream gene expression remain unclear. During sprouting angiogenesis, the specification of endothelial cells into the tip cells that lead new blood vessel sprouts is coordinated by vascular endothelial growth factor A (VEGFA) and Delta-like ligand 4 (Dll4)/Notch signaling and requires high levels of Notch ligand DLL4...
October 15, 2016: Genes & Development
https://www.readbyqxmd.com/read/27890575/3d-hybrid-modelling-of-vascular-network-formation
#5
Holger Perfahl, Barry D Hughes, Tomás Alarcón, Philip K Maini, Mark C Lloyd, Matthias Reuss, Helen M Byrne
We develop an off-lattice, agent-based model to describe vasculogenesis, the de novo formation of blood vessels from endothelial progenitor cells during development. The endothelial cells that comprise our vessel network are viewed as linearly elastic spheres that move in response to the forces they experience. We distinguish two types of endothelial cells: vessel elements are contained within the network and tip cells are located at the ends of vessels. Tip cells move in response to mechanical forces caused by interactions with neighbouring vessel elements and the local tissue environment, chemotactic forces and a persistence force which accounts for their tendency to continue moving in the same direction...
November 24, 2016: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/27887628/implications-of-vessel-co-option-in-sorafenib-resistant-hepatocellular-carcinoma
#6
Elizabeth A Kuczynski, Robert S Kerbel
The reason why tumors generally have a modest or transient response to antiangiogenic therapy is not well understood. This poses a major challenge for sorafenib treatment of advanced hepatocellular carcinoma (HCC) where alternate therapies are lacking. We recently published a paper entitled "Co-option of liver vessels and not sprouting angiogenesis drives acquired sorafenib resistance in hepatocellular carcinoma" in the Journal of the National Cancer Institute, providing a potential explanation for this limited benefit...
November 25, 2016: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/27880939/inhibition-of-the-transcriptional-repressor-complex-bcl-6-bcor-induces-endothelial-sprouting-but-does-not-promote-tumor-growth
#7
Elisabeth Buchberger, Dietmar Payrhuber, Miriam El Harchi, Branislav Zagrapan, Katharina Scheuba, Anna Zommer, Edina Bugyik, Balazs Dome, Julia Barbara Kral, Waltraud Cornelia Schrottmaier, Gernot Schabbauer, Peter Petzelbauer, Marion Gröger, Martin Bilban, Christine Brostjan
The oncogenic potential of the transcriptional repressor Bcl-6 (B-cell lymphoma 6) was originally discovered in non-Hodgkin patients and the soluble Bcl-6 inhibitor 79-6 was developed to treat diffuse large B-cell lymphomas with aberrant Bcl-6 expression. Since we found Bcl-6 and its co-repressor BCoR (Bcl-6 interacting co-repressor) to be regulated in human microvascular endothelium by colorectal cancer cells, we investigated their function in sprouting angiogenesis which is central to tumor growth. Based on Bcl-6/BCoR gene silencing we found that the transcriptional repressor complex in fact constitutes an endogenous inhibitor of vascular sprouting by supporting the stalk cell phenotype: control of Notch target genes (HES1, HEY1, DLL4) and cell cycle regulators (cyclin A and B1)...
November 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/27864565/targeting-non-canonical-nuclear-factor-%C3%AE%C2%BAb-signalling-attenuates-neovascularization-in-a-novel-3d-model-of-rheumatoid-arthritis-synovial-angiogenesis
#8
Chrissta X Maracle, Paulina Kucharzewska, Boy Helder, Corine van der Horst, Pedro Correa de Sampaio, Ae-Ri Noort, Katinka van Zoest, Arjan W Griffioen, Henric Olsson, Sander W Tas
OBJECTIVE: Angiogenesis is crucial in RA disease progression. Lymphotoxin β receptor (LTβR)-induced activation of the non-canonical nuclear factor-κB (NF-κB) pathway via NF-κB-inducing kinase (NIK) has been implicated in this process. Consequently, inhibition of this pathway may hold therapeutic potential in RA. We describe a novel three-dimensional (3D) model of synovial angiogenesis incorporating endothelial cells (ECs), RA fibroblast-like synoviocytes (RAFLSs) and RA synovial fluid (RASF) to further investigate the contributions of NF-κB in this process...
November 17, 2016: Rheumatology
https://www.readbyqxmd.com/read/27864233/aging-is-associated-with-impaired-angiogenesis-but-normal-microvascular-network-structure-in-the-rat-mesentery
#9
Richard S Sweat, David C Sloas, Scott A Stewart, Malwina Czarny-Ratajczak, Melody Baddoo, James R Eastwood, Ariana D Suarez-Martinez, Mohammad Sadegh Azimi, Hope E Burks, Lee O Chedister, Leann Myers, Walter Lee Murfee
A big problem associated with aging is thought to be impaired microvascular growth or angiogenesis. However, in order to link the evidence for impaired angiogenesis to microvascular dysfunction in aged tissues, we must compare adult versus aged microvascular networks in unstimulated scenarios. The objective of this study was to test the hypothesis that aged microvascular networks are characterized by both fewer vessels and the impaired ability to undergo angiogenesis. Mesentery tissues from adult (9 months) and aged (24 months) male Fischer 344 rats were harvested and immunolabeled for PECAM (an endothelial cell marker) according to two scenarios: unstimulated and stimulated...
November 18, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27852824/differential-receptor-binding-and-regulatory-mechanisms-for-the-lymphangiogenic-growth-factors-vegf-c-and-vegf-d
#10
Natalia Davydova, Nicole C Harris, Sally Roufail, Sophie Paquet-Fifield, Musarat Ishaq, Victor A Streltsov, Steven P Williams, Tara Karnezis, Steven A Stacker, Marc G Achen
VEGF-C(2) and VEGF-D are secreted glycoproteins that induce angiogenesis and lymphangiogenesis in cancer, thereby promoting tumor growth and spread. They exhibit structural homology and activate VEGFR-2 and VEGFR-3, receptors on endothelial cells that signal for growth of blood vessels and lymphatics. VEGF-C and VEGF-D were thought to exhibit similar bioactivities, yet recent studies indicated distinct signalling mechanisms, e.g. tumor-derived VEGF-C promoted expression of the prostaglandin biosynthetic enzyme COX-2 in lymphatics, a response thought to facilitate metastasis via the lymphatic vasculature, whereas VEGF-D did not...
November 16, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27852438/radial-glia-regulate-vascular-patterning-around-the-developing-spinal-cord
#11
Ryota L Matsuoka, Michele Marass, Avdesh Avdesh, Christian Sm Helker, Hans-Martin Maischein, Ann S Grosse, Harmandeep Kaur, Nathan D Lawson, Wiebke Herzog, Didier Yr Stainier
Vascular networks surrounding individual organs are important for their development, maintenance, and function; however, how these networks are assembled remains poorly understood. Here we show that CNS progenitors, referred to as radial glia, modulate vascular patterning around the spinal cord by acting as negative regulators. We found that radial glia ablation in zebrafish embryos leads to excessive sprouting of the trunk vessels around the spinal cord, and exclusively those of venous identity. Mechanistically, we determined that radial glia control this process via the Vegf decoy receptor sFlt1: sflt1 mutants exhibit the venous over-sprouting observed in radial glia-ablated larvae, and sFlt1 overexpression rescues it...
November 17, 2016: ELife
https://www.readbyqxmd.com/read/27846305/time-to-decide-dynamical-analysis-predicts-partial-tip-stalk-patterning-states-arise-during-angiogenesis
#12
Lakshmi Venkatraman, Erzsébet Ravasz Regan, Katie Bentley
Angiogenesis is a highly dynamic morphogenesis process; however, surprisingly little is known about the timing of the different molecular processes involved. Although the role of the VEGF-notch-DLL4 signaling pathway has been established as essential for tip/stalk cell competition during sprouting, the speed and dynamic properties of the underlying process at the individual cell level has not been fully elucidated. In this study, using mathematical modeling we investigate how specific, biologically meaningful, local conditions around and within an individual cell can influence their unique tip/stalk phenotype switching kinetics...
2016: PloS One
https://www.readbyqxmd.com/read/27835862/a-novel-mutation-in-nuclear-prelamin-a-recognition-factor-like-causes-diffuse-pulmonary-arteriovenous-malformations
#13
Hong-Zhou Liu, Chun-Xian Du, Jing Luo, Xue-Ping Qiu, Zu-Hua Li, Qi-Yong Lou, Zhan Yin, Fang Zheng
Two daughters in a Chinese consanguineous family were diagnosed as diffuse pulmonary arteriovenous malformations (PAVMs) and screened using whole exome sequencing (WES) and copy number variations (CNVs) chips. Though no mutation was found in the established causative genes of capillary malformation-AVMs (CM-AVMs) or PAVMs, Ser161Ile (hg19 NM_022493 c.482G>T) mutation in nuclear prelamin A recognition factor-like (NARFL) was identified. Ser161Ile mutation in NARFL conservation region was predicted to be deleterious and absent in 500 population controls and Exome Aggregation Consortium (ExAC) Database...
November 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27828952/computational-screening-of-tip-and-stalk-cell-behavior-proposes-a-role-for-apelin-signaling-in-sprout-progression
#14
Margriet M Palm, Marchien G Dallinga, Erik van Dijk, Ingeborg Klaassen, Reinier O Schlingemann, Roeland M H Merks
Angiogenesis involves the formation of new blood vessels by sprouting or splitting of existing blood vessels. During sprouting, a highly motile type of endothelial cell, called the tip cell, migrates from the blood vessels followed by stalk cells, an endothelial cell type that forms the body of the sprout. To get more insight into how tip cells contribute to angiogenesis, we extended an existing computational model of vascular network formation based on the cellular Potts model with tip and stalk differentiation, without making a priori assumptions about the differences between tip cells and stalk cells...
2016: PloS One
https://www.readbyqxmd.com/read/27793618/differential-expression-of-endothelial-nutrient-transporters-mct1-and-glut1-in-the-developing-eyes-of-mice
#15
Ayuko Kishimoto, Hiromi Takahashi-Iwanaga, Masahiko Watanabe M, Toshihiko Iwanaga
The blood-brain barrier in the neonatal brain expresses the monocarboxylate transporter (MCT)-1 rather than the glucose transporter (GLUT)-1, due to the special energy supply during the suckling period. The hyaloid vascular system, consisting of the vasa hyaloidea propria and tunica vasculosa lentis, is a temporary vasculature present only during the early development of mammalian eyes and later regresses. Although the ocular vasculature manifests such a unique developmental process, no information is available concerning the expression of endothelial nutrient transporters in the developing eye...
October 26, 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27789478/microrna-126a-directs-lymphangiogenesis-through-interacting-with-chemokine-and-flt4-signaling-in-zebrafish
#16
Jian Chen, Rong-Fang Zhu, Fang-Fang Li, Yu-Lai Liang, Chen Wang, Yong-Wen Qin, Shuang Huang, Xian-Xian Zhao, Qing Jing
OBJECTIVE: MicroRNA-126 (miR-126) is an endothelium-enriched miRNA and functions in vascular integrity and angiogenesis. The application of miRNA as potential biomarker and therapy target has been widely investigated in various pathological processes. However, its role in lymphatic diseases had not been widely explored. We aimed to reveal the role of miR-126 in lymphangiogenesis and the regulatory signaling pathways for potential targets of therapy. APPROACH AND RESULTS: Loss-of-function studies using morpholino oligonucleotides and CRISPR/Cas9 system showed that silencing of miR-126a severely affected the formation of parachordal lymphangioblasts and thoracic duct in zebrafish embryos, although their development in miR-126b knockdown embryos was normal...
October 27, 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27787863/characterization-of-semaphorin-6a-mediated-effects-on-angiogenesis-through-regulation-of-vegf-signaling
#17
Hidetaka Ohnuki, Giovanna Tosato
Angiogenesis identifies the process of endothelial cell sprouting and remodeling leading to the formation of new and functional blood vessels. Vascular expansion during development and in the adult mammal provides nutrients and oxygen to areas with increased need. Although many molecules and pathways have been identified as regulators of angiogenesis, aspects of this complex process remain unclear. Particularly undefined are the signals that orchestrate vessel survival and pruning once new blood vessels have sprouted...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27780917/the-somite-secreted-factor-maeg-promotes-zebrafish-embryonic-angiogenesis
#18
Xin Wang, Wei Yuan, Xueqian Wang, Jialing Qi, Yinyin Qin, Yunwei Shi, Jie Zhang, Jie Gong, Zhangji Dong, Xiaoyu Liu, Chen Sun, Renjie Chai, Ferdinand Le Noble, Dong Liu
MAM and EGF containing gene (MAEG), also called Epidermal Growth Factor-like domain multiple 6 (EGFL6), belongs to the epidermal growth factor repeat superfamily. The role of Maeg in zebrafish angiogenesis remains unclear. It was demonstrated that maeg was dynamically expressed in zebrafish developing somite during a time window encompassing many key steps in embryonic angiogenesis. Maeg loss-of-function embryos showed reduced endothelial cell number and filopodia extensions of intersegmental vessels (ISVs)...
October 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/27777113/subsets-of-telocytes-myocardial-telocytes
#19
M C Rusu, S Hostiuc, A D Vrapciu, L Mogoantă, V S Mănoiu, F Grigoriu
Telocytes (TCs) are morphologically defined as small-sized cells with long, thin, moniliform processes called telopodes (Tps). Numerous papers imply that TCs are a distinctive cell type, and that transmission electron microscopy (TEM) is the gold standard tool for their identification. We aimed to reproduce previous studies on myocardial TCs to check their validity. For this purpose we performed an immunohistochemical study on human cardiac samples from six autopsied donor cadavers, using antibodies against CD10, CD31, CD34, CD146, Ki67, alpha-smooth muscle actin (α-SMA), Platelet-Derived Growth Factor Receptor-alpha (PDGFRα) and laminin...
October 21, 2016: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/27760539/chemotherapeutic-potentials-of-the-stem-bark-of-balanite-aegyptiaca-l-delile-an-antiangiogenic-antitumor-and-antioxidant-agent
#20
Loiy E Ahmed Hassan, Saad S Dahham, Sultan Ayesh Mohammed Saghir, Abdelhafeez M A Mohammed, Nagla M Eltayeb, Amin Malik Shah Abdul Majid, Aman Shah Abdul Majid
BACKGROUND: Balanite aegyptiaca (L.) Delile, is a plant with extensive medicinal properties. Its stem bark is traditionally known for its spasmolytic and antiepileptic properties and used to treat yellow fever, jaundice and syphilis. Angiogenesis (sprouting of new blood vessels) is crucial for tumor growth and metastasis. The goal of this study is investigate the antiangiogenic, cytotoxicity and antioxidant activity as well as antitumor in vivo properties of B. aegyptiaca stem bark extracts...
October 19, 2016: BMC Complementary and Alternative Medicine
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