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https://www.readbyqxmd.com/read/28929580/selective-expression-of-egfp-in-mouse-perivascular-astrocytes-by-modification-of-the-mlc1-gene-using-t2a-based-ribosome-skipping
#1
Jordan J Toutounchian, Joseph H McCarty
Perivascular astrocyte end feet closely juxtapose cerebral blood vessels to regulate important developmental and physiological processes including endothelial cell proliferation and sprouting as well as the formation of the blood-brain barrier (BBB). The mechanisms underlying these events remain largely unknown due to a lack of experimental models for identifying perivascular astrocytes and distinguishing these cell types from other astroglial populations. Megalencephalic leukoencephalopathy with subcortical cysts 1 (Mlc1) is a transmembrane protein that is expressed in perivascular astrocyte end feet where it controls BBB development and homeostasis...
September 20, 2017: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/28927933/azopolymer-photopatterning-for-directional-control-of-angiogenesis
#2
Chiara Fedele, Maria De Gregorio, Paolo A Netti, Silvia Cavalli, Chiara Attanasio
Understanding cellular behavior in response to microenvironmental stimuli is central to tissue engineering. An increasing number of reports emphasize the high sensitivity of cells to the physical characteristics of the surrounding milieu and in particular, topographical cues. In this work, we investigated the influence of dynamic topographic signal presentation on sprout formation and the possibility to obtain a space-time control over sprouting directionality without growth factors, in order to investigate the contribution of just topography in the angiogenic process...
September 16, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28926106/oroxyloside-inhibits-angiogenesis-through-suppressing-internalization-of-vegfr2-flk-1-in-endothelial-cells
#3
Kai Zhao, Xiaorui Li, Binyan Lin, Dawei Yang, Yuxin Zhou, Zhiyu Li, Qinglong Guo, Na Lu
Increasing flavonoids have been reported to possess anti-angiogenic effects. Inhibition of angiogenesis plays a critical role in the treatment of cancer, especially in advanced metastatic cancer. In this study, we assessed the effect of Oroxylin A-7-glucuronide (Oroxyloside), a main metabolite of Oroxylin A, on angiogenesis in human endothelial cell-like EA.hy926 cells. Oroxyloside suppressed the migration and tube formation of EA.hy926 cells. Meanwhile, microvessels sprouting from aortic rings and new blood vessels on the chicken chorioallantoic membrane (CAM) were also inhibited...
September 19, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28925736/chronological-changes-in-tip-cells-during-sprouting-angiogenesis-of-development-of-the-retinal-vasculature-in-newborn-mice
#4
Chang Sik Cho, Sang-Mok Lee, Byung Joo Lee, Dong Hyun Jo, Jin Hyoung Kim, Jeong Hun Kim, Young Suk Yu
PURPOSE: To investigate a sequential chronological change in tip cells during the development of the retinal vasculature in newborn mice. MATERIALS AND METHODS: Newborn C57BL/6 mice were used for this study. To elucidate the patterns in the developing retinal vasculature, histology, and immunohistochemistry-antiplatelet endothelial cell adhesion molecule-1, anticollagen type IV, isolectin IB4-were performed on sections of mouse retina on postnatal days (P)-4, -8, and -12...
September 19, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28871312/alk1-signaling-in-development-and-disease-new-paradigms
#5
REVIEW
Beth L Roman, Andrew P Hinck
Activin A receptor like type 1 (ALK1) is a transmembrane serine/threonine receptor kinase in the transforming growth factor-beta receptor family that is expressed on endothelial cells. Defects in ALK1 signaling cause the autosomal dominant vascular disorder, hereditary hemorrhagic telangiectasia (HHT), which is characterized by development of direct connections between arteries and veins, or arteriovenous malformations (AVMs). Although previous studies have implicated ALK1 in various aspects of sprouting angiogenesis, including tip/stalk cell selection, migration, and proliferation, recent work suggests an intriguing role for ALK1 in transducing a flow-based signal that governs directed endothelial cell migration within patent, perfused vessels...
September 4, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28865439/apln-creert-mt-mg-reporter-mice-as-a-tool-for-sprouting-angiogenesis-study
#6
Jingjiang Pi, Yu Cheng, Huimin Sun, Xiaoli Chen, Tao Zhuang, Jie Liu, Yixi Li, Huan Chang, Lin Zhang, YuZhen Zhang, Ting Tao
BACKGROUND: Angiogenesis is defined as a new blood vessel sprouting from pre-existing vessels, and the sprouting angiogenesis is the start phase of angiogenesis, which is critical for both physiological and pathological processes, such as embryonic development, organ growth, wound healing, tumor growth, diabetic retinopathy and age-related macular degeneration. Better understanding of the mechanisms of sprout angiogenesis will provide a rationale for the treatments of these angiogenesis related diseases...
September 2, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28862956/sirtuin-3-deficiency-accelerates-hypertensive-cardiac-remodeling-by-impairing-angiogenesis
#7
Tong Wei, Gaojian Huang, Jing Gao, Chenglin Huang, Mengwei Sun, Jian Wu, Juan Bu, Weili Shen
BACKGROUND: Emerging evidence indicates that impaired angiogenesis may contribute to hypertension-induced cardiac remodeling. The nicotinamide adenine dinucleotide-dependent deacetylase Sirtuin 3 (SIRT3) has the potential to modulate angiogenesis, but this has not been confirmed. As such, the aim of this study was to examine the relationship between SIRT3-mediated angiogenesis and cardiac remodeling. METHODS AND RESULTS: Our experiments were performed on SIRT3 knockout and age-matched wild-type mice infused with angiotensin II (1400 ng/kg per minute) or saline for 14 days...
August 19, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28859292/exosomes-secreted-by-cardiomyocytes-subjected-to-ischaemia-promote-cardiac-angiogenesis
#8
Teresa M Ribeiro-Rodrigues, Tiago L Laundos, Rita Pereira-Carvalho, Daniela Batista-Almeida, Ricardo Pereira, Vanessa Coelho-Santos, Ana P Silva, Rosa Fernandes, Monica Zuzarte, Francisco J Enguita, Marina C Costa, Perpetua Pinto-do-Ó, Marta T Pinto, Pedro Gouveia, Lino Ferreira, Justin C Mason, Paulo Pereira, Brenda R Kwak, Diana S Nascimento, Henrique Girão
Aims: Myocardial infarction (MI) is the leading cause of morbidity and mortality worldwide and results from an obstruction in the blood supply to a region of the heart. In an attempt to replenish oxygen and nutrients to the deprived area, affected cells release signals to promote the development of new vessels and confer protection against MI. However, the mechanisms underlying the growth of new vessels in an ischaemic scenario remain poorly understood. Here, we show that cardiomyocytes subjected to ischaemia release exosomes that elicit an angiogenic response of endothelial cells (ECs)...
September 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28840018/the-role-of-bone-marrow-derived-endothelial-progenitor-cells-and-angiogenic-responses-in-chronic-obstructive-pulmonary-disease
#9
REVIEW
Brittany Salter, Roma Sehmi
Increased vascularity of the bronchial sub-mucosa is a cardinal feature of chronic obstructive pulmonary disease (COPD) and is associated with disease severity. Capillary engorgement, leakage, and vasodilatation can directly increase airway wall thickness resulting in airway luminal narrowing and facilitate inflammatory cell trafficking, thereby contributing to irreversible airflow obstruction, a characteristic of COPD. Airway wall neovascularisation, seen as increases in both the size and number of bronchial blood vessels is a prominent feature of COPD that correlates with reticular basement membrane thickening and airway obstruction...
July 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28838921/tortuous-microvessels-contribute-to-wound-healing-via-sprouting-angiogenesis
#10
Diana C Chong, Zhixian Yu, Hailey E Brighton, James E Bear, Victoria L Bautch
OBJECTIVE: Wound healing is accompanied by neoangiogenesis, and new vessels are thought to originate primarily from the microcirculation; however, how these vessels form and resolve during wound healing is poorly understood. Here, we investigated properties of the smallest capillaries during wound healing to determine their spatial organization and the kinetics of formation and resolution. APPROACH AND RESULTS: We used intravital imaging and high-resolution microscopy to identify a new type of vessel in wounds, called tortuous microvessels...
August 24, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28805663/yap-taz-regulates-sprouting-angiogenesis-and-vascular-barrier-maturation
#11
Jongshin Kim, Yoo Hyung Kim, Jaeryung Kim, Do Young Park, Hosung Bae, Da-Hye Lee, Kyun Hoo Kim, Seon Pyo Hong, Seung Pil Jang, Yoshiaki Kubota, Young-Guen Kwon, Dae-Sik Lim, Gou Young Koh
Angiogenesis is a multistep process that requires coordinated migration, proliferation, and junction formation of vascular endothelial cells (ECs) to form new vessel branches in response to growth stimuli. Major intracellular signaling pathways that regulate angiogenesis have been well elucidated, but key transcriptional regulators that mediate these signaling pathways and control EC behaviors are only beginning to be understood. Here, we show that YAP/TAZ, a transcriptional coactivator that acts as an end effector of Hippo signaling, is critical for sprouting angiogenesis and vascular barrier formation and maturation...
August 14, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28796914/actinic-keratoses-show-variable-histological-basal-growth-patterns-a-proposed-classification-adjustment
#12
L Schmitz, T Gambichler, G Gupta, M Stücker, E Stockfleth, R M Szeimies, T Dirschka
BACKGROUND: Common histological classification schemes of actinic keratoses (AK) do not evaluate growth patterns at basal epidermal aspects of AK. Until now, the importance of basal epidermal growth patterns of AK has not been studied. OBJECTIVE: To investigate the extent of atypical keratinocytes throughout the epidermis and variation in basal growth patterns of AK. METHODS: AK lesions occurring on the head/face from patients seen in routine practice were assessed histologically...
August 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28783156/hydrogels-with-precisely-controlled-integrin-activation-dictate-vascular-patterning-and%C3%A2-permeability
#13
Shuoran Li, Lina R Nih, Haylee Bachman, Peng Fei, Yilei Li, Eunwoo Nam, Robert Dimatteo, S Thomas Carmichael, Thomas H Barker, Tatiana Segura
Integrin binding to bioengineered hydrogel scaffolds is essential for tissue regrowth and regeneration, yet not all integrin binding can lead to tissue repair. Here, we show that through engineering hydrogel materials to promote α3/α5β1 integrin binding, we can promote the formation of a space-filling and mature vasculature compared with hydrogel materials that promote αvβ3 integrin binding. In vitro, α3/α5β1 scaffolds promoted endothelial cells to sprout and branch, forming organized extensive networks that eventually reached and anastomosed with neighbouring branches...
September 2017: Nature Materials
https://www.readbyqxmd.com/read/28775072/lmo2-lim-domain-only-2-modulates-sphk1-sphingosine-kinase-and-promotes-endothelial-cell-migration
#14
Gianfranco Matrone, Shu Meng, Qilin Gu, Jie Lv, Longhou Fang, Kaifu Chen, John P Cooke
OBJECTIVE: Lmo (LIM-domain-only)2 transcription factor is involved in hematopoiesis and vascular remodeling. Sphk (sphingosine kinase)1 phosphorylates sphingosine to S1P (sphingosine-1-phosphate). We hypothesized that Lmo2 regulates Sphk1 to promote endothelial cell (EC) migration and vascular development. APPROACH AND RESULTS: Lmo2 and Sphk1 knockdown (KD) were performed in Tg(fli1:EGFP) (y1) zebra fish and in human umbilical vein EC. Rescue of phenotypes or overexpression of these factors were achieved using mRNA encoding Lmo2 or Sphk1...
August 3, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28763512/a-glycan-based-approach-to-therapeutic-angiogenesis
#15
Jie Shi Chua, Vy M Tran, Mausam Kalita, Maritza V Quintero, Orlando Antelope, Geethu Muruganandam, Yukio Saijoh, Balagurunathan Kuberan
Angiogenesis, the sprouting of new blood vessels from existing vasculature, involves multiple complex biological processes, and it is an essential step for hemostasis, tissue healing and regeneration. Angiogenesis stimulants can ameliorate human disease conditions including limb ischemia, chronic wounds, heart disease, and stroke. The current strategies to improve the bioavailability of pro-angiogenic growth factors, including VEGF and FGF2, have remained largely unsuccessful. This study demonstrates that small molecules, termed click-xylosides, can promote angiogenesis in the in vitro matrigel tube formation assay and the ex ovo chick chorioallantoic membrane assay, depending on their aglycone moieties...
2017: PloS One
https://www.readbyqxmd.com/read/28762551/monocarboxylate-transporter-1-is-a-key-player-in-glioma-endothelial-cell-crosstalk
#16
Vera Miranda-Gonçalves, Filipa Bezerra, Raquel Costa-Almeida, Marta Freitas-Cunha, Raquel Soares, Olga Martinho, Rui M Reis, Céline Pinheiro, Fátima Baltazar
Glioblastoma (GBM) is one of the most glycolytic and angiogenic human tumours, characteristics that contribute to the poor prognosis associated with this type of tumour. A lactate shuttle has been described between tumour cells and endothelial cells (ECs), with the monocarboxylate transporters (MCTs) acting as important players in this tumour-EC communication. In this study, we aimed to understand how the tumour microenvironment modulates EC metabolism, and to characterize the role of MCTs in the glioma-brain EC crosstalk...
August 1, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28762232/morphofunctional-basis-of-the-different-types-of-angiogenesis-and-formation-of-postnatal-angiogenesis-related-secondary-structures
#17
REVIEW
L Díaz-Flores, R Gutiérrez, M P García-Suárez, F J Sáez, E Gutiérrez, F Valladares, J L Carrasco, L Díaz-Flores, J F Madrid
We review the morpho-functional basis of the different types of angiogenesis and report our observations, including the formation of angiogenesis-related secondary structures. First of all, we consider the following issues: a) conceptual differences between angiogenesis and vasculogenesis, b) incidence of angiogenesis in pre- and postnatal life, c) regions of vascular tree with angiogenic capacity, d) cells (endothelial cells, pericytes, CD34+ adventitial stromal cells of the microvasculature and inflammatory cells) and extracellular matrix components involved in angiogenesis, e) events associated with angiogenesis, f) different types of angiogenesis, including sprouting and intussusceptive angiogenesis, and other angiogenic or vascularization forms arising from endothelial precursor cells (postnatal vasculogenesis), vasculogenesis mimicry, vessel co-option and piecemeal angiogenesis...
August 1, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28757355/15-lipoxygenase-1-re-expression-in-colorectal-cancer-alters-endothelial-cell-features-through-enhanced-expression-of-tsp-1-and-icam-1
#18
Sinem Tunçer, Ayşe Gökçe Keşküş, Melis Çolakoğlu, Ismail Çimen, Caner Yener, Özlen Konu, Sreeparna Banerjee
15-lipoxygenase-1 (15-LOX-1) oxygenates linoleic acid to 13(S)-hydroxyoctadecadienoic acid (HODE). The enzyme is widely suppressed in different cancers and its re-expression has tumor suppressive effects. 15-LOX-1 has been shown to inhibit neoangiogenesis in colorectal cancer (CRC); in the present study we confirm this phenomenon and describe the mechanistic basis. We show that re-expression of 15-LOX-1 in CRC cell lines resulted in decreased transcriptional activity of HIF1α and reduced the expression and secretion of VEGF in both normoxic and hypoxic conditions...
November 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28756150/a-marine-sponge-alkaloid-derivative-4-chloro-fascaplysin-inhibits-tumor-growth-and-vegf-mediated-angiogenesis-by-disrupting-pi3k-akt-mtor-signaling-cascade
#19
Sonia Sharma, Santosh Kumar Guru, Sudhakar Manda, Ashok Kumar, Mubashir J Mintoo, Venna Deva Prasad, Parduman R Sharma, Dilip M Mondhe, Sandip B Bharate, Shashi Bhushan
Tumor angiogenesis and PI3K/Akt/mTOR pathway are two major molecular objectives for the treatment and management of breast cancer. Here we first time report the molecular mechanism of a marine sponge alkaloid derivative 4-chloro fascapysin (4-CF) for its anticancer and antiangiogenesis potential. It simultaneously targets multiple cancer and angiogenesis dynamics, such as proliferation, chemotaxis cell migration, and invasion, growth factors signaling cascade, autophagy and apoptosis in HUVEC and MDAMB-231 breast cancer cells...
July 26, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28753665/quantification-of-sympathetic-hyperinnervation-and-denervation-after-myocardial-infarction-by-three-dimensional-assessment-of-the-cardiac-sympathetic-network-in-cleared-transparent-murine-hearts
#20
Teruki Yokoyama, Jong-Kook Lee, Keiko Miwa, Tobias Opthof, Satoki Tomoyama, Hiroyuki Nakanishi, Akira Yoshida, Haruyo Yasui, Tadatsune Iida, Shigeru Miyagawa, Shigeo Okabe, Yoshiki Sawa, Yasushi Sakata, Issei Komuro
BACKGROUND: The sympathetic nervous system is critical in maintaining the normal physiological function of the heart. Its dysfunction in pathological states may exacerbate the substrate for arrhythmias. Obviously, knowledge of its three-dimensional (3D) structure is important, however, it has been revealed by conventional methods only to a limited extent. In this study, a new method of tissue clearance in combination with immunostaining unravels the 3D structure of the sympathetic cardiac network as well as its changes after myocardial infarction...
2017: PloS One
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