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Transportation Determinant of Health

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https://www.readbyqxmd.com/read/28436536/early-vertebrate-origin-and-diversification-of-small-transmembrane-regulators-of-cellular-ion-transport
#1
Sergej Pirkmajer, Henriette Kirchner, Leonidas Lundell, Pavel V Zelenin, Juleen R Zierath, Kira S Makarova, Yuri I Wolf, Alexander V Chibalin
Small transmembrane proteins are important for regulation of cellular ion transport. The most prominent among these proteins are members of the FXYD family (FXYD1-12), which regulate Na(+) -K(+) -ATPase, and phospholamban, sarcolipin, myoregulin, and DWORF, which regulate the sarco-endoplasmic reticulum Ca(2+) -ATPase (SERCA). FXYDs and regulators of SERCA are present in fishes, as well as terrestrial vertebrates; however, their evolutionary origins and phylogenetic relationships are obscure, thus hampering comparative physiological studies...
April 24, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28435190/prevalence-of-salmonella-in-poultry-processing-environments-in-wet-markets-in-penang-and-perlis-malaysia
#2
Hafiz Nidaullah, Nadarajan Abirami, Ahamed Kamal Shamila-Syuhada, Li-Oon Chuah, Huda Nurul, Teik Pei Tan, Farah Wahida Zainal Abidin, Gulam Rusul
AIM: The aim of this study was to determine the prevalence of various Salmonella serotypes in chickens, carcass contact surfaces as well as environmental samples collected from wet markets and small scale processing plant. MATERIALS AND METHODS: A total of 182 poultry and environmental samples were collected at random on separate occasions from wet markets and small scale processing plant, during the period of October 2014 to July 2015 in Penang and Perlis, Malaysia...
March 2017: Veterinary World
https://www.readbyqxmd.com/read/28432371/impact-of-diabetes-mellitus-on-occupational-health-outcomes-in-canada
#3
Anson Kc Li, Behdin Nowrouzi-Kia
BACKGROUND: Research suggests that diabetes mellitus (DM) has a negative impact on employment and workplace injury, but there is little data within the Canadian context. OBJECTIVE: To determine if DM has an impact on various occupational health outcomes using the Canadian Community Health Survey (CCHS). METHODS: CCHS data between 2001 and 2014 were used to assess the relationships between DM and various occupational health outcomes. The final sample size for the 14-year study period was 505 606, which represented 159 432 239 employed Canadians aged 15-75 years during this period...
April 2017: International Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28427367/determinants-of-delayed-care-seeking-for-tb-suggestive-symptoms-in-seru-district-oromiya-region-ethiopia-a-community-based-unmatched-case-control-study
#4
Robel Yirgu, Firaol Lemessa, Selamawit Hirpa, Abraham Alemayehu, Eveline Klinkenberg
BACKGROUND: Early tuberculosis (TB) case finding and adequate chemotherapy are essential for interrupting disease transmission and preventing complications due to delayed care seeking. This study was undertaken in order to provide insights into the magnitude and determinants of patient delay. METHODS: The study was conducted in rural Seru district, employing a population based unmatched case-control study design. The WHO standardized TB screening tool was used to identify presumptive TB cases among the district population ages > 15 years...
April 20, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28425071/micro-spatial-variation-of-elemental-distribution-in-estuarine-sediment-and-their-accumulation-in-mangroves-of-indian-sundarban
#5
Madhurima Bakshi, S S Ram, Somdeep Ghosh, Anindita Chakraborty, M Sudarshan, Punarbasu Chaudhuri
This work describes the micro-spatial variation of elemental distribution in estuarine sediment and bioaccumulation of those elements in different mangrove species of the Indian Sundarbans. The potential ecological risk due to such elemental load on this mangrove-dominated habitat is also discussed. The concentrations of elements in mangrove leaves and sediments were determined using energy-dispersive X-ray fluorescence spectroscopy. Sediment quality and potential ecological risks were assessed from the calculated indices...
May 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28412619/denitrification-potential-in-the-subsurface-environment-in-the-manawatu-river-catchment-new-zealand-indications-from-oxidation-reduction-conditions-hydrogeological-factors-and-implications-for-nutrient-management
#6
Aldrin Rivas, Ranvir Singh, David Horne, Jonathan Roygard, Abby Matthews, Michael J Hedley
A sound understanding of the effects of hydrogeological factors on loss, transport and transformation of farm nutrients is essential for predicting their impacts on ecosystem health of receiving waters. We assessed the potential of groundwater to attenuate nitrate through denitrification, and the distribution of this potential across the Tararua Groundwater Management Zone (GWMZ) in the Manawatu River catchment, New Zealand. We combined a number of methods in an unprecedented manner to confirm findings and obtain supporting evidence for the features that determine the subsurface denitrification characteristics...
April 13, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28411942/transplacental-nutrient-transfer-in-the-human-in%C3%A2-vivo-determined-by-4-vessel-sampling
#7
Trond M Michelsen, Ane M Holme, Tore Henriksen
BACKGROUND: The intrauterine environment and especially the fetal nutritional conditions affect lifelong health. There are few human in vivo studies on fetal nutrition. The importance to test experimentally based concepts of fetal nutrition in a human in vivo setting is becoming increasingly apparent. A way of testing nutrient transfer in human is 4-vessel sampling, which implies blood sampling from artery and vein on both sides of the placenta. Here we give a brief review of the studies using the 4-vessel sampling method...
March 24, 2017: Placenta
https://www.readbyqxmd.com/read/28410759/state-level-immigration-and-immigrant-focused-policies-as-drivers-of-latino-health-disparities-in-the-united-states
#8
Morgan M Philbin, Morgan Flake, Mark L Hatzenbuehler, Jennifer S Hirsch
There has been a great deal of state-level legislative activity focused on immigration and immigrants over the past decade in the United States. Some policies aim to improve access to education, transportation, benefits, and additional services while others constrain such access. From a social determinants of health perspective, social and economic policies are intrinsically health policies, but research on the relationship between state-level immigration-related policies and Latino health remains scarce. This paper summarizes the existing evidence about the range of state-level immigration policies that affect Latino health, indicates conceptually plausible but under-explored relationships between policy domains and Latino health, traces the mechanisms through which immigration policies might shape Latino health, and points to key areas for future research...
April 7, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28408909/the-maternal-diet-gut-bacteria-and-bacterial-metabolites-during-pregnancy-influence-offspring-asthma
#9
REVIEW
Lawrence E K Gray, Martin O'Hely, Sarath Ranganathan, Peter David Sly, Peter Vuillermin
This review focuses on the current evidence that maternal dietary and gut bacterial exposures during pregnancy influence the developing fetal immune system and subsequent offspring asthma. Part 1 addresses exposure to a farm environment, antibiotics, and prebiotic and probiotic supplementation that together indicate the importance of bacterial experience in immune programming and offspring asthma. Part 2 outlines proposed mechanisms to explain these associations including bacterial exposure of the fetoplacental unit; immunoglobulin-related transplacental transport of gut bacterial components; cytokine signaling producing fetomaternal immune alignment; and immune programming via metabolites produced by gut bacteria...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28405705/-cost-effectiveness-of-gnrh-antagonists-in-patients-with-prostate-cancer-and-cardiovascular-risk-comparative-analysis-against-leuprorelin-by-the-number-needed-to-treat
#10
D Anderson, J Lehmann, T Ecker, S Vosgerau, V Donatz
BACKGROUND: Recent studies suggest that androgen deprivation therapy (ADT) is associated with increased cardiovascular (CV) risk for patients with hormone-sensitive prostate cancer (PCa) and pre-existing CV disease. This risk seems to be different for the gonadotropin-releasing hormone (GnRH) agonists leuprolide and goserelin and GnRH antagonists, whereas the slightly more expensive GnRH antagonist shows a beneficial risk profile. The present study assesses the cost effectiveness of degarelix compared to leuprolide for PCa patients with increased CV risk...
April 12, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28403813/beliefs-and-practices-during-pregnancy-post-partum-and-in-the-first-days-of-an-infant-s-life-in-rural-cambodia
#11
Claudia Turner, Sreymom Pol, Kamsan Suon, Leakhena Neou, Nicholas P J Day, Michael Parker, Patricia Kingori
BACKGROUND: The aim of this study was to record the beliefs, practices during pregnancy, post-partum and in the first few days of an infant's life, held by a cross section of the community in rural Cambodia to determine beneficial community interventions to improve early neonatal health. METHODS: Qualitative study design with data generated from semi structured interviews (SSI) and focus group discussions (FGD). Data were analysed by thematic content analysis, with an a priori coding structure developed using available relevant literature...
April 12, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28400957/sociodemographic-behavioral-and-environmental-factors-of-child-mortality-in-eastern-region-of-cameroon-results-from-a-social-autopsy-study
#12
Alain K Koffi, Romain S Wounang, Félicitée Nguefack, Seidou Moluh, Paul-Roger Libite, Henry D Kalter
BACKGROUND: While most child deaths are caused by highly preventable and treatable diseases such as pneumonia, diarrhea, and malaria, several sociodemographic, cultural and health system factors work against children surviving from these diseases. METHODS: A retrospective verbal/social autopsy survey was conducted in 2012 to measure the biological causes and social determinants of under-five years old deaths from 2007 to 2010 in Doume, Nguelemendouka, and Abong-Mbang health districts in the Eastern Region of Cameroon...
June 2017: Journal of Global Health
https://www.readbyqxmd.com/read/28397536/infant-carrying-methods-correlates-and-associated-musculoskeletal-disorders-among-nursing-mothers-in-nigeria
#13
Chidiebele Petronilla Ojukwu, Godson Emeka Anyanwu, Emelie Morris Anekwu, Sylvester Caesar Chukwu, Chukwubuikem Fab-Agbo
Infant carrying is an integral part of the mothering occupation. Paucity of data exists on its correlates and associated musculoskeletal injuries. In this study, factors and musculoskeletal injuries associated with infant carrying were investigated in 227 nursing mothers, using a structured questionnaire. 77.1% utilised the back infant carrying methods (ICM). Maternal comfort was the major factor influencing participants' (37.4%) choices of ICMs. Infant's age (p = .000) and transportation means (p = ...
April 11, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28394286/sodium-p-aminosalicylic-acid-reverses-sub-chronic-manganese-induced-impairments-of-spatial-learning-and-memory-abilities-in-rats-but-fails-to-restore-%C3%AE-aminobutyric-acid-levels
#14
Shao-Jun Li, Chao-Yan Ou, Sheng-Nan He, Xiao-Wei Huang, Hai-Lan Luo, Hao-Yang Meng, Guo-Dong Lu, Yue-Ming Jiang, Tanara Vieira Peres, Yi-Ni Luo, Xiang-Fa Deng
Excessive manganese (Mn) exposure is not only a health risk for occupational workers, but also for the general population. Sodium para-aminosalicylic acid (PAS-Na) has been successfully used in the treatment of manganism, but the involved molecular mechanisms have yet to be determined. The present study aimed to investigate the effects of PAS-Na on sub-chronic Mn exposure-induced impairments of spatial learning and memory, and determine the possible involvements of γ-aminobutyric acid (GABA) metabolism in vivo...
April 10, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28388722/thyroid-and-islet-autoantibodies-predict-autoimmune-thyroid-disease-at-type-1-diabetes-diagnosis
#15
Berglind Jonsdottir, Christer Larsson, Annelie Carlsson, Gun Forsander, Sten Anders Ivarsson, Åke Lernmark, Johnny Ludvigsson, Claude Marcus, Ulf Samuelsson, Eva Örtqvist, Helena Elding Larsson
Context: Screening of autoimmune thyroid disease in children with type 1 diabetes is important but varies between clinics. Objective: To determine the predictive value of thyroid autoantibodies, thyroid function, islet autoantibodies, and HLA-DQ at diagnosis of type 1 diabetes for autoimmune thyroid disease during follow-up. Setting: Forty-three Swedish pediatric endocrinology units. Design, Patients, and Main Outcome Measures: At diagnosis of type 1 diabetes, autoantibodies against thyroid peroxidase (TPOAb), thyroglobulin (TGAb), glutamic acid decarboxylase (GADA), insulin, insulinoma-associated protein-2, and 3 variants of zinc transporter 8 (ZnT8W/R/QA) HLA-DQA1-B1 genotypes and thyroid function were analyzed in 2433 children...
April 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28387709/screening-for-cd-safe-cultivars-of-chinese-cabbage-and-a-preliminary-study-on-the-mechanisms-of-cd-accumulation
#16
Jingjie Wang, Nan Yu, Guangmao Mu, Kamran I Shinwari, Zhenguo Shen, Luqing Zheng
With the rapid progress of industrialization, the effects of environmental contamination on plant toxicity, and subsequently on human health, is a growing concern. For example, the heavy metal pollution of soil such as that caused by cadmium (Cd) is a serious threat. Therefore, screening for pollution-safe edible plants is an essential approach for growing plants under heavy metal-contaminated soils. In the current study, 35 Chinese cabbage (Brassica pekinensis L.) cultivars were selected with the aim of screening for Cd-safe cultivars (CSCs), analyzing their safety, and exploring the mechanism of Cd accumulation...
April 7, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28386764/roles-of-tau-protein-in-health-and-disease
#17
REVIEW
Tong Guo, Wendy Noble, Diane P Hanger
Tau is well established as a microtubule-associated protein in neurons. However, under pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied by synaptic dysfunction and neural cell death in a range of neurodegenerative disorders, collectively referred to as tauopathies. Recent advances in our understanding of the multiple functions and different locations of tau inside and outside neurons have revealed novel insights into its importance in a diverse range of molecular pathways including cell signalling, synaptic plasticity, and regulation of genomic stability...
May 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/28381221/ozone-and-childhood-respiratory-disease-in-three-us-cities-evaluation-of-effect-measure-modification-by-neighborhood-socioeconomic-status-using-a-bayesian-hierarchical-approach
#18
Cassandra R O' Lenick, Howard H Chang, Michael R Kramer, Andrea Winquist, James A Mulholland, Mariel D Friberg, Stefanie Ebelt Sarnat
BACKGROUND: Ground-level ozone is a potent airway irritant and a determinant of respiratory morbidity. Susceptibility to the health effects of ambient ozone may be influenced by both intrinsic and extrinsic factors, such as neighborhood socioeconomic status (SES). Questions remain regarding the manner and extent that factors such as SES influence ozone-related health effects, particularly across different study areas. METHODS: Using a 2-stage modeling approach we evaluated neighborhood SES as a modifier of ozone-related pediatric respiratory morbidity in Atlanta, Dallas, & St...
April 5, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28374471/a-high-proportion-of-prehospital-emergency-patients-are-not-transported-by-ambulance-a-retrospective-cohort-study-in-northern-finland
#19
M Hoikka, T Silfvast, T I Ala-Kokko
BACKGROUND: The number of missions in the emergency medical services (EMS) has increased considerably in recent years. People are requesting ambulance for even minor illnesses and non-medical problems, which is placing financial and resource burdens on the EMS. The aim of this study was to determine the rate of non-transportation missions in Northern Finland and the reasons for these missions. METHODS: All ambulance missions in two hospital districts in Northern Finland during the 6-month period of January 1 through June 30, 2014, were retrospectively evaluated from the EMS charts to identify missions in which the patients were not transported by the EMS...
May 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/28373758/typhoid-intestinal-perforation-in-developing-countries-still-unavoidable-deaths
#20
EDITORIAL
Sandro Contini
Typhoid fever is a public health challenge mostly concentrated in impoverished, overcrowded areas of the developing world, with lack of safe drinking and sanitation. The most serious complication is typhoid intestinal perforation (TIP), observed in 0.8% to 39%, with a striking rate difference between high-income and low-middle-income countries. Although the mortality rate consequent to TIP in resource-poor countries is improved in the last decades, it is still fluctuating from 5% to 80%, due to surgical- and not surgical-related constraints...
March 21, 2017: World Journal of Gastroenterology: WJG
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