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https://www.readbyqxmd.com/read/28743030/reactive-ceo2-nanofluids-for-uv-protective-films
#1
Rafael Maniglia, Kenneth J Reed, John Texter
We investigate surface modification by organo-trimethoxysilanes of nano-ceria and if such surface-modified nano-ceria can be transformed into solvent-free nanofluids. We also examine whether simultaneous modification with ionic liquid salts and with acrylate groups yields nanofluids suitable for forming UV-protective films and clear coatings by UV-initiated polymerization. Nominally 3nm diameter CeO2 was successfully synthesized and surface decorated with an ionic liquid salt and with acrylate groups to produce a core/shell structured solvent-free nanofluid after ion exchange of chloride for a soft polyoxyethylene sulfonate anion...
July 18, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28742856/fit-for-genomic-and-proteomic-purposes-sampling-the-fitness-of-nucleic-acid-and-protein-derivatives-from-formalin-fixed-paraffin-embedded-tissue
#2
Anna Yakovleva, Jordan L Plieskatt, Sarah Jensen, Razan Humeida, Jonathan Lang, Guangzhao Li, Paige Bracci, Sylvia Silver, Jeffrey Michael Bethony
The demand for nucleic acid and protein derivatives from formalin-fixed paraffin-embedded (FFPE) tissue has greatly increased due to advances in extraction and purification methods, making these derivatives available for numerous genomic and proteomic platforms. Previously, DNA, RNA, microRNA (miRNA), or protein derived from FFPE tissue blocks were considered "unfit" for such platforms, as the process of tissue immobilization by FFPE resulted in cross-linked, fragmented, and chemically modified macromolecules...
2017: PloS One
https://www.readbyqxmd.com/read/28742363/improved-performance-of-glucose-bioanodes-using-composites-of-7-6-single-walled-carbon-nanotubes-and-a-ferrocene-lpei-redox-polymer
#3
Jie Chen, Rujuta Munje, Nicholas P Godman, Shalini Prasad, Daniel T Glatzhofer, David W Schmidtke
The effect of incorporating different types of carbon nanotubes into composite films of a redox polymer (FcMe2-C3-LPEI) and glucose oxidase (GOX) was investigated. The composite films were constructed by first forming a high-surface area network film of either single-walled carbon nanotubes (SWNTs) or multiwalled carbon nanotubes (MWNTs) on a glassy carbon electrode (GCE) by solution casting of a suspension of Triton-X-100 dispersed SWNTs. Next a glucose responsive redox hydrogel was formed on top of the nanotube-modified electrode by cross-linking FcMe2-C3-LPEI with glucose oxidase via ethylene glycol diglycidyl ether (EGDGE)...
July 25, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28742335/5-formylcytosine-yields-dna-protein-cross-links-in-nucleosome-core-particles
#4
Fengchao Li, Yingqian Zhang, Jing Bai, Marc M Greenberg, Zhen Xi, Chuanzheng Zhou
In situ generation of 5-formylcytosine (5fC) in nucleosome core particles (NCPs) reveals that 5fC leads to essential DNA-protein cross-links (DPCs). Mechanistic studies using chemical models and mutated histones demonstrate that DPCs form reversibly between the formyl function of 5fC and primary amines on histones. These results suggest that DPC formation from 5fC in chromatin occurs in addition to its role in DNA demethylation.
July 25, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28741857/surface-cross-linked-ultra-high-molecular-weight-polyethylene-by-emulsified-diffusion-of-dicumyl-peroxide
#5
Sanem Kayandan, Brinda N Doshi, Ebru Oral, Orhun K Muratoglu
Cross-linking improves the wear resistance of ultrahigh molecular weight polyethylene (UHMWPE) used in hip and knee implants. Free radicals, generated by ionizing radiation or chemically, react to form cross-links. Limiting cross-linking to the articulating surface of the implant is desirable to enable high wear resistance on the surface and higher strength and toughness in the bulk. We investigated the diffusion of emulsified dicumyl peroxide (DCP) into vitamin E-blended UHMWPE (0.1 and 0.3 wt. % vitamin-E) with subsequent thermal decomposition in situ to obtain surface cross-linking with the objective of achieving surface wear rate equivalent or lower than that of current clinically available materials...
July 25, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28740362/scleral-wound-healing-with-cross-link-technique-using-riboflavin-and-ultraviolet-a-on-rabbit-eyes
#6
Nadyr A Damasceno, Nadia C Miguel, Marcelo Palis Ventura, Miguel Burnier, Marcos P Avila, Eduardo F Damasceno
PURPOSE: The aim of study was to evaluate the cross-link using riboflavin and ultraviolet A (UVA) for improving scleral wound healing. MATERIALS AND METHODS: This was an experimental study involving four New Zealand rabbits (eight eyes). Therapy procedure was chosen for the right eye and control procedure for the left one. UVA irradiation of 365 nm with a surface irradiance of 3 mW/cm(2) and a photosensitizer of riboflavin drops were applied for 30 minutes on the right eye at 2 mm from the limbus...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28739410/1-3-5-triazine-2-4-6-tribenzaldehyde-derivative-as-a-new-crosslinking-agent-for-synthesis-of-ph-thermo-dual-responsive-chitosan-hydrogels-and-their-nanocomposites-swelling-properties-and-drug-release-behavior
#7
Ali Reza Karimi, Mahsa Tarighatjoo, Golara Nikravesh
In this work, 1,3,5-triazine-2,4,6-tribenzaldehyde was synthesized and chosen as the cross-linking agent for preparation of novel thermo- and pH-responsive hydrogels based on chitosan. The cross-linking proceeds through formation of imine bond by reaction of amino groups of chitosan with aldehyde groups of the cross-linker. The various amounts (6, 10, 14% w/w) of the cross-linker were used with respect to chitosan to produce three 1,3,5-triazine-2,4,6-tribenzaldehyde cross-linked chitosans. Then, their hydrogel nanocomposites were prepared by crosslinking of chitosan with 1,3,5-triazine-2,4,6-tribenzaldehyde in the presence of 0...
July 21, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28739409/fabrication-of-au-iii-ion-imprinted-polymer-based-on-thiol-modified-chitosan
#8
M Monier, D A Abdel-Latif
Au(III) ions were selectively extracted from aqueous media using Au(III) ion-imprinted bio-adsorbent based on modified chitosan (Au-CMB). First, 2-mercaptobenzaldehyde-chitosan Schiff base was prepared and interacted with Au(III) ions. The obtained polymeric Au(III) complex was then cross-linked by epichlorohydrin (ECH) before leaching the template Au(III) ions out of the cross-linked matrix. During the synthetic procedures, the obtained chitosan derivatives were characterized by Elemental analysis, FTIR and NMR spectra...
July 21, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28739407/ultrasensitive-transglutaminase-based-nanosensor-for-early-detection-of-celiac-disease-in-human
#9
Shagun Gupta, Ankur Kaushal, Ashok Kumar, Dinesh Kumar
A GQD/PAMAM nanohybrid modified on gold nanoparticles (AuNP) embedded in multiwalled carbon nanotubes (MWCNT) based immunosensor was developed for detection of celiac disease in human. The AuNP embedded in MWCNT were linked with thiol groups of cysteine and amino groups were further coupled with carboxyl moieties of graphene quantum dots (GQDs) using EDC-NHS cross-linking chemistry. To enhance the sensitivity of the sensor, polyamidoamine (PAMAM) dendrimer was attached with GQDs through carbodiimide coupling...
July 21, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28738643/facile-preparation-of-3-d-floor-like-ordered-mesoporous-carbon-functionalized-graphene-composites-and-its-application-for-selective-enrichment-of-n-glycans-from-human-serum
#10
Quanqing Zhang, Yuanyu Huang, Haofan Sun, Yangyang Gan, Huali Shen, Bin Jia, Pengyuan Yang
Novel 3-D floor-like ordered mesoporous carbon functionalized graphene composites, FLOMC-GO, with high graphitized carbon contents were successfully synthesized using a soft template method. The one-pot sol-gel method was employed to prepare the silica soft template. Then, the sandwich-like composites were further combined together to form a 3-D structure through pre-carbonization and carbonization. During these procedures, the sulphonyl and sulfide bridges were formed by cross-linking processes to connect the phenyl rings...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28737967/integral-membrane-proteins-bottom-up-top-down-and-structural-proteomics
#11
Upendra Karr, Margaret Simonian, Julian P Whitelegge
Integral membrane proteins and lipids constitute the bilayer membranes that surround cells and sub-cellular compartments, and modulate movements of molecules and information between them. Since membrane protein drug targets represent a disproportionately large segment of the proteome, technical developments need timely review. Areas covered and literature search strategy: Publically available resources such as Pubmed were surveyed. Bottom-up proteomics analyses now allow efficient extraction and digestion such that membrane protein coverage is essentially complete, making up around one third of the proteome...
July 24, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28737037/polyimide-aerogels-using-tri-isocyanate-as-cross-linker
#12
Baochau N Nguyen, Mary Ann Babin Meador, Daniel A Scheiman, Linda S McCorkle
Cross-linked polyimide (PI) aerogels are highly porous, lightweight materials with low thermal conductivity and low dielectric constant. Depending on the backbone chemistry, the cross-linked polyimide aerogels can be molded into various size and shape or cast into flexible, thin film. They are excellent candidates for many applications including antenna-based substrate, thermal insulation for space suits or inflatable structures for entry, descent and landing, or industrial pipelines, protective clothing or building and construction...
July 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28736835/peptide-mimetics-of-immunoglobulin-a-iga-and-fc%C3%AE-ri-block-iga-induced-human-neutrophil-activation-and-migration
#13
Marieke H Heineke, Lydia P E van der Steen, Rianne M Korthouwer, J Joris Hage, Johannes P M Langedijk, Joris J Benschop, Jantine E Bakema, Jerry W Slootstra, Marjolein van Egmond
The cross-linking of the IgA Fc receptor (FcαRI) by IgA induces release of the chemoattractant LTB4, thereby recruiting neutrophils in a positive feedback loop. IgA autoantibodies of patients with autoimmune blistering skin diseases therefore induce massive recruitment of neutrophils, resulting in severe tissue damage. To interfere with neutrophil mobilization and reduce disease morbidity, we developed a panel of specific peptides mimicking either IgA or FcαRI sequences. CLIPS technology was used to stabilize three-dimensional structures and to increase peptides' half-life...
July 24, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28736823/distinct-alignment-of-benzene-derivatives-in-stretched-polystyrene-and-polybutylacrylate-gels-specific-polymer-solute-interactions
#14
Thomas Niklas, Christian Steinmetzger, Franziska Rüttger, Dietmar Stalke, Michael John
We have measured the alignment of a range of benzene derivatives in cross-linked polystyrene (PS) and poly(butyl acrylate) (PBA) using a small number of residual dipolar couplings (RDCs) and simple geometric considerations. For apolar solutes in PS and protic solutes in PBA, the preferred molecular orientation does not coincide with the longest molecular axis (steric aligment). This behaviour may be explained by specific π-π and hydrogen bonding interactions between solute and polymer, respectively, the latter being confirmed by molecular dynamics (MD) simulations...
July 23, 2017: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/28735002/immobilization-of-%C3%AE-galactosidase-on-surface-modified-cobalt-multiwalled-carbon-nanotube-nanocomposite-improves-enzyme-stability-and-resistance-to-inhibitor
#15
Maryam Khan, Qayyum Husain, Rani Bushra
The present study aimed to work out a high yield procedure for immobilization of Aspergillus oryzae β-galactosidase on polyaniline cobalt multiwalled carbon nanotubes nanocomposite (PANI/Co/MWCNTNC) by physical adsorption and covalent attachment via glutaraldehyde. The binding was confirmed by scanning and transmission electron microscopy along with Fourier transform-infrared spectroscopy. The immobilization yields obtained for adsorbed and cross-linked enzymes were 93% and 97%, respectively. The covalently immobilized enzyme was remarkably more stable at extremes of pH and temperature compared to native and adsorbed enzymes...
July 19, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28734664/ph-responsive-biodegradable-nanogels-for-sustained-release-of-bleomycin
#16
Prashant Sahu, Sushil K Kashaw, Varun Kushwah, Samaresh Sau, Sanyog Jain, Arun K Iyer
Site specific drug delivery with desired therapeutic effect still remains challenging task due to suboptimal release, tissue toxicity, low selectivity and meager therapeutic efficacy in skin cancers. The aim of the current study was to fabricate pH responsive, self-assembled, chemically cross-linked biodegradable chitosan nanogel loaded with bleomycin to target the dermal area of the skin. The nanogel synthesized by ion gelation technique and was characterized for drug loading, swelling and thermal stability followed by in vitro analysis...
June 27, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28734615/highly-cross-linked-polyethylene-reduces-osteolysis-incidence-and%C3%A2-wear-related-reoperation-rate-in-cementless-total-hip-arthroplasty%C3%A2-compared-with-conventional-polyethylene-at%C3%A2-a%C3%A2-mean%C3%A2-12-year-follow-up
#17
Manabu Tsukamoto, Toshiharu Mori, Hideo Ohnishi, Soshi Uchida, Akinori Sakai
BACKGROUND: A number of studies on total hip arthroplasty have compared highly cross-linked polyethylene (HXLPE) with conventional polyethylene (CPE) liners beyond 10 years. However, the impact of HXLPE on the wear-related reoperation rate is unclear. The purpose of this study was to evaluate the clinical advantage of using a single manufacturer's HXLPE in terms of reducing the reoperation rate. METHODS: The study was a follow-up retrospective cohort study over a mean of 12 years that examined patients aged 45-70 years with cementless total hip arthroplasty using a 26-mm-diameter cobalt-chromium head...
July 8, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28734256/3d-porous-polyurethanes-featured-by-different-mechanical-properties-characterization-and-interaction-with-skeletal-muscle-cells
#18
Lorenzo Vannozzi, Leonardo Ricotti, Tommaso Santaniello, Tercio Terencio, Reinier Oropesa-Nunez, Claudio Canale, Francesca Borghi, Arianna Menciassi, Cristina Lenardi, Irini Gerges
The fabrication of biomaterials for interaction with muscle cells has attracted significant interest in the last decades. However, 3D porous scaffolds featured by a relatively low stiffness (almost matching the natural muscle one) and highly stable in response to cyclic loadings are not available at present, in this context. This work describes 3D polyurethane-based porous scaffolds featured by different mechanical properties. Biomaterial stiffness was finely tuned by varying the cross-linking degree of the starting foam...
July 14, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28733348/molecular-forms-of-ruminant-bmp15-and-gdf9-and-putative-interactions-with-receptors
#19
Derek A Heath, Janet Pitman, Kenneth P McNatty
Bone morphogenetic factor 15 (BMP15) and growth differentiation factor 9 (GDF9) are oocyte-secreted factors with demonstrable effects on ovarian follicular development and ovulation-rate. However, the molecular forms of BMP15 and GDF9 produced by oocytes remains unclear. The aims herein, using Western blotting (WB) procedures with specific monoclonal antibodies (mabs), were to identify the molecular forms of BMP15 and GDF9 synthesised and secreted by isolated ovine (o) and bovine (b) oocytes in vitro. The mabs were known to recognise the biological forms of BMP15 or GDF9 since they had previously been shown to inhibit their bioactivities in vitro and in vivo...
July 21, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28733212/the-peroxyl-radical-induced-oxidation-of-escherichia-coli-ftsz-and-its-single-tryptophan-mutant-y222w-modifies-specific-side-chains-generates-protein-cross-links-and-affects-biological-function
#20
Elizabeth Escobar-Álvarez, Fabian Leinisch, Gissela Araya, Octavio Monasterio, Lasse G Lorentzen, Eduardo Silva, Michael J Davies, Camilo López-Alarcón
FtsZ (filamenting temperature-sensitive mutant Z) is a key protein in bacteria cell division. The wild-type Escherichia coli FtsZ sequence (FtsZwt) contains three tyrosine (Tyr, Y) and sixteen methionine (Met, M) residues. The Tyr at position 222 is a key residue for FtsZ polymerization. Mutation of this residue to tryptophan (Trp, W; mutant Y222W) inhibits GTPase activity resulting in an extended time in the polymerized state compared to FtsZwt. Protein oxidation has been highlighted as a determinant process for bacteria resistance and consequently oxidation of FtsZwt and the Y222W mutant, by peroxyl radicals (ROO•) generated from AAPH (2,2'-azobis(2-methylpropionamidine) dihydrochloride) was studied...
July 18, 2017: Free Radical Biology & Medicine
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