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https://www.readbyqxmd.com/read/29764778/lower-beclin-1-mrna-levels-in-pediatric-compared-with-adult-patients-with-otitis-media-with-effusion
#1
Kim Sang Hoon, Kim Myung Gu, Shim Haeng Seon, Kim Sung Su, Kim Young Il, Yeo Seung Geun
OBJECTIVES: The role of autophagy in the pathophysiology of otitis media with effusion (OME) remains unclear, particularly regarding the difference between pediatric and adult patients. The present study analyzed the expression levels of autophagy-associated mRNAs in effusion fluids obtained from pediatric and adult patients with OME. MATERIALS AND METHODS: Middle ear fluid samples were collected from 76 pediatric patients and 41 adult patients with OME, and the levels of mRNAs encoding autophagy-related genes were measured using real-time reverse transcription-polymerase chain reaction...
April 2018: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29764722/middle-ear-disease-in-children-with-cleft-palate
#2
REVIEW
Tulasi Kota Karanth, Kenneth R Whittemore
OBJECTIVE: The objective of this review is to summarize all aspects of middle ear diseases in children with cleft palate (CP). METHODS: PubMed, Scopus, The Cumulative Index to Nursing and Allied Health Literature (CINAHL) and The Cochrane Library were searched for English-language randomized control trials (RCTs), meta-analyses, systematic reviews and observational studies published through 31st July 2017. RESULTS: Epidemiology and pathogenesis of middle ear diseases in children with cleft palate have been discussed in this review...
May 12, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29753496/an-evidence-based-protocol-for-managing-neonatal-middle-ear-effusions-in-babies-who-fail-newborn-hearing-screening
#3
Brittany C Weber, Scott M Whitlock, Kaidi He, Blake S Kimbrell, Craig S Derkay
OBJECTIVES: To evaluate the prevalence of middle ear disease in infants referred for failed newborn hearing screening (NBHS) and to review patient outcomes after intervention in order to propose an evidence-based protocol for management of newborns with otitis media with effusion (OME) who fail NBHS. METHODS: 85 infants with suspected middle ear pathology were retrospectively reviewed after referral for failed NBHS. All subjects underwent a diagnostic microscopic exam with myringotomy with or without placement of a ventilation tube in the presence of a middle ear effusion and had intra-operative auditory brainstem response (ABR) testing or testing at a later date...
April 12, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29741289/grommets-ventilation-tubes-for-recurrent-acute-otitis-media-in-children
#4
REVIEW
Roderick P Venekamp, Paul Mick, Anne Gm Schilder, Desmond A Nunez
BACKGROUND: Acute otitis media (AOM) is one of the most common childhood illnesses. While many children experience sporadic AOM episodes, an important group suffer from recurrent AOM (rAOM), defined as three or more episodes in six months, or four or more in one year. In this subset of children AOM poses a true burden through frequent episodes of ear pain, general illness, sleepless nights and time lost from nursery or school. Grommets, also called ventilation or tympanostomy tubes, can be offered for rAOM...
May 9, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29624209/withdrawn-grommets-ventilation-tubes-for-recurrent-acute-otitis-media-in-children
#5
REVIEW
Loretta Lau, Paul Mick, Desmond A Nunez
BACKGROUND: This is an update of a Cochrane review first published in The Cochrane Library in Issue 4, 2008 and previously updated in 2011.Acute suppurative otitis media is one of the most common infectious diseases in childhood. Recurrent acute otitis media is defined for the purposes of this review as either three or more acute infections of the middle ear cleft in a six-month period, or at least four episodes in a year. Strategies for managing the condition include the assessment and modification of risk factors where possible, repeated courses of antibiotics for each new infection, antibiotic prophylaxis and the insertion of ventilation tubes (grommets)...
April 6, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29602585/trend-in-otolaryngological-surgeries-in-an-era-of-super-aging-descriptive-statistics-using-a-japanese-inpatient-database
#6
Sayaka Suzuki, Hideo Yasunaga, Hiroki Matsui, Kiyohide Fushimi, Tatsuya Yamasoba
OBJECTIVE: To reveal the age distribution and capture the longitudinal trend in otolaryngological surgeries performed in Japan, where society is rapidly aging. METHODS: Using the Diagnosis Procedure Combination database, we extracted data on patients who were hospitalized and underwent any type of otolaryngological surgery in departments of otolaryngology or head and neck surgery from fiscal year 2007 to fiscal year 2013. Type of surgery, patient's age, and fiscal year were compared...
March 27, 2018: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29600829/our-experience-of-the-necessity-of-adenoidectomy-or-adenotonsillectomy-at-the-time-of-ventilation-tube-insertion-in-11-941-children-with-middle-ear-effusion
#7
James Johnston, Gabrielle Kinzett-Carran, Murali Mahadevan, Richard G Douglas
Adenoidectomy and tonsillectomy are commonly performed at the time of myringotomy plus ventilation tube insertion (MVTI) in children with otitis media with effusion (OME). However, the evidence supporting this practice is not conclusive. This is because uncertainty remains regarding the pathogenic role of the adenoids in OME. It is unclear if mechanical obstruction is a more or less important factor than the adenoids' role as a bacterial reservoir. Some studies show that children who have large adenoids removed have higher rates of effusion resolution compared to those children with small adenoids...
March 30, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29587475/microbiological-results-from-middle-ear-effusion-in-pediatric-patients-receiving-ventilation-tube-insertion-multicenter-registry-study-on-the-effectiveness-of-ventilation-tube-insertion-in-pediatric-patients-with-chronic-otitis-media-with-effusion-part-i
#8
Myung Hoon Yoo, Yang-Sun Cho, June Choi, Yun Hoon Choung, Jae-Ho Chung, Jong Woo Chung, Gyu Cheol Han, Eun-Ju Jeon, Beom Cho Jun, Dong-Kee Kim, Kyu Sung Kim, Jun Ho Lee, Kyu-Yup Lee, Seung Hwan Lee, In Seok Moon, Hong Ju Park, Shi Nae Park, Jihye Rhee, Jae Hyun Seo, Seung Geun Yeo
Objectives: The aim of this multicenter registry study was to investigate the effectiveness of ventilation tube insertion and the microbiology of otitis media with effusion (OME) in children. This part I study was conducted to evaluate the microbiological profile of children with OME who needed ventilation tube insertion. Methods: Patients <15 years old who were diagnosed as having OME and received ventilation tube insertion were prospectively enrolled in 16 tertiary hospitals from June 2014 to December 2016...
March 28, 2018: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/29573766/-quality-of-life-of-children-with-otitis-media-and-impact-of-insertion-of-transtympanic-ventilation-tubes-in-a-portuguese-population
#9
Ana Rita Lameiras, Deodato Silva, Assunção O Neill, Pedro Escada
INTRODUCTION: Quality of life is an important measure for health-outcome evaluation. Although otitis media is one of the most common childhood diseases, its impact on Portuguese children's quality of life is unknown. The aim of this study is to determine the quality of life of Portuguese children with chronic otitis media with effusion and/or recurrent acute otitis media and the short-term impact of transtympanic ventilation tubes, using the Portuguese version of the OM-6 questionnaire, a valid, reliable and sensitive instrument to evaluate the health-related quality of life in children with otitis media...
January 31, 2018: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/29554447/surveillance-of-otitis-media-with-effusion-in-thai-children-with-cleft-palate-cumulative-incidence-and-outcome-of-the-management
#10
Kitirat Ungkanont, Panrasee Boonyabut, Chulaluk Komoltri, Archwin Tanphaichitr, Vannipa Vathanophas
OBJECTIVE: To study the incidence and outcome of management of otitis media with effusion in Thai children with cleft palate. DESIGN: Retrospective cohort study in the tertiary care center. PATIENTS: Ninety-five children with cleft palate were referred for ear evaluation, from June 1997 to January 2015. Fifteen children (15.8%) had associated craniofacial syndromic anomalies. MAIN OUTCOME MEASURES: Cumulative incidence of otitis media with effusion, rate of ventilation tube insertion, duration of indwelling tubes, hearing outcome, and complications of ventilation tubes...
April 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29532729/thomsen-j-et-al-the-non-specific-effect-of-endolymphatic-sac-surgery-in-treatment-of-meniere-s-disease-a-prospective-randomized-controlled-study-comparing-classic-endolymphatic-sac-surgery-with-the-insertion-of-a-ventilating-tube-in-tympanic-membrane-acta-oto
#11
https://www.readbyqxmd.com/read/29501296/a-randomized-study-of-four-different-types-of-tympanostomy-ventilation-tubes-full-term-follow-up
#12
RANDOMIZED CONTROLLED TRIAL
Johan Knutsson, Claudia Priwin, Anne-Charlotte Hessén-Söderman, Andreas Rosenblad, Magnus von Unge
OBJECTIVE: To evaluate the impact of tympanostomy ventilation tube material (silicone vs fluoroplastic) and shape (short vs long) regarding time to extrusion, occurrence of otorrhea, occlusion, tube removal and occurrence of persistent perforation. METHODS AND MATERIAL: Four different types of ventilation tubes were used; Long Armstrong tubes, Donaldson tubes, Shepard tubes and straight tubes, representing four specific combinations of VT material (silicone or fluoroplastic) and shape (short, double flanged or long, single flanged)...
April 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29489418/otologic-outcomes-with-two-different-surgical-protocols-in-patients-with-a-cleft-palate-a-retrospective-study
#13
Grégoire D'Andréa, Claude Maschi, Charles Savoldelli, Hervé Caci, Sonanda Bailleux
OBJECTIVE: To compare otologic outcomes in patients with cleft palate who underwent 2 different surgical protocols. DESIGN: Monocentric retrospective analysis of medical reports. PATIENTS, PARTICIPANTS: All consecutively treated patients affected by a cleft palate, born between January 1998 and December 2002 (group 1) and between January 2007 and December 2010 (group 2). INTERVENTIONS: Patients in group 1 underwent Veau-Wardill-Kilner palatoplasty at 10 months and had ventilation tubes inserted in case of otitis media with effusion (OME) during surgery...
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29447793/clinical-role-of-vitamin-d-in-prognosis-of-otitis-media-with-effusion
#14
Fatih Alper Akcan, Yusuf Dündar, Hümeyra Bayram Akcan, Ahmet Uluat, Derya Cebeci, Mehmet Ali Sungur, İlhan Ünlü
OBJECTIVE: To investigate the clinical role of Vitamin D in prognosis of Otitis media with effusion. METHODS: This prospective-controlled study was conducted at otolaryngology department in Duzce University, Turkey. The study group comprised children who were diagnosed with Otitis media with effusion between September 2016 and February 2017. Control group was conducted with children underwent circumcision or inguinal hernia repair operations that confirmed with ENT examination they do not have any sign of otitis media...
February 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29435712/antimicrobial-therapy-in-palliative-care-an-overview
#15
REVIEW
Filipa Macedo, Catarina Nunes, Katia Ladeira, Filipa Pinho, Nadine Saraiva, Nuno Bonito, Luísa Pinto, Francisco Gonçalves
In the advanced stages of illness, patients often face challenging decisions regarding their treatment and overall medical care. Terminal ill patients are commonly affected by infections. However, in palliative care, the use of antimicrobials can be an ethical dilemma. Deciding whether to treat, withhold, or withdraw the antimicrobial treatment for an infection can be difficult. Antimicrobial administration can lead to adverse outcomes but the two main benefits, longer survival and symptom relief, are the main reasons why physicians prescribe antimicrobial when treating terminally ill patients...
May 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29398506/international-consensus-icon-on-management-of-otitis-media-with-effusion-in-children
#16
F Simon, M Haggard, R M Rosenfeld, H Jia, S Peer, M-N Calmels, V Couloigner, N Teissier
Otitis media with effusion (OME) is a common childhood disease defined as the presence of liquid in the middle ear without signs or symptoms of acute ear infection. Children can be impacted mainly with hearing impairment and/or co-occurring recurrent acute otitis media (AOM) thus requiring treatment. Although many meta-analyses and national guidelines have been issued, management remains difficult to standardize, and use of surgical and medical treatments continue to vary. We convened an international consensus conference as part of the 2017 International Federation of Oto-rhino-laryngological Societies Congress, to identify best practices in OME management...
February 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29161200/early-placement-of-ventilation-tubes-in-infants-with-cleft-lip-and-palate-a-systematic-review
#17
Mark Felton, Jong Wook Lee, Darius D Balumuka, Jugpal S Arneja, Neil K Chadha
Objective Studies have shown that the majority of cleft lip and palate (CLP) children have middle ear fluid present at the time of lip repair (3-4 months). Despite hearing loss, the majority of children do not undergo ventilation tube treatment if required until the time of palate repair (9-12 months). We aimed to examine the effectiveness and potential complications of early ventilation tube placement prior to palatoplasty in infants with cleft lip and palate. Data Sources Medline (1946-2015), Embase (1980-2015), and EBM Reviews (Cochrane Central Register of Controlled)...
March 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28988664/epidemiology-and-antimicrobial-susceptibility-of-non-typeable-haemophilus-influenzae-in-otitis-media-in-taiwanese-children
#18
Ying-Chun Cho, Nan-Chang Chiu, Fu-Yuan Huang, Daniel Tsung-Ning Huang, Lung Chang, Ching-Ying Huang, Yen-Hsin Kung, Kuo-Sheng Lee, Hsin Chi
BACKGROUND: Concerns about non-typeable Haemophilus influenzae (NTHi) in otitis media (OM) have grown after the introduction of pneumococcal conjugate vaccine (PCV). We aim to better understand the clinical role of NTHi in pediatric OM. METHODS: Middle ear fluid samples from children <18 years with OM were obtained from 2010 to 2015. For culture-positive episodes (Streptococcus pneumoniae, H. influenzae, Moraxella catarrhalis, and Streptococcus pyogenes), patients' demographic and clinical information were reviewed and analyzed...
September 18, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28984803/long-term-complications-and-surgical-failures-after-ossiculoplasty
#19
Matthew D Cox, Joshua Cody Page, Aaron Trinidade, John L Dornhoffer
OBJECTIVE: To study long-term complications after ossiculoplasty. STUDY DESIGN: Case series with chart review. SETTING: Tertiary care referral center otology practice. PATIENTS: One hundred ninety-five patients (18-88 yr of age) undergoing ossiculoplasty with tympanoplasty or tympanomastoidectomy using cartilage tympanic membrane grafts, retrograde mastoidectomy with canal wall reconstruction, or mastoid obliteration techniques between July 1998 and July 2012...
December 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28964286/the-expression-and-correlation-of-hsp-70-and-hsp-27-in-serous-middle-ear-effusion-fluids-of-pediatric-patients-a-preliminary-study
#20
Hyun Jin Min, Ji Won Choe, Moon Young Chang, Kyung Soo Kim, Sei Young Lee, Seog-Kyun Mun
OBJECTIVES: Several cytokines and innate immune-associated molecules are present in middle ear effusions, but damage-associated molecular patterns (DAMPs) in middle ear effusion have not been studied. Therefore, we evaluated the role of heat shock proteins (Hsps) in the development of otitis media with effusion (OME). METHODS: Serous middle ear effusions from 22 pediatric patients who were diagnosed with OME and underwent ventilation tube insertion from June 2015 to March 2017 were evaluated in our study...
October 2017: International Journal of Pediatric Otorhinolaryngology
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